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Home > Indoles and Oxindole > 16990-73-1
16990-73-1 | 1H-indol-2-ol
CAS No: 16990-73-1 Catalog No: AG00AKVE MDL No:MFCD00005711
Product Description
Catalog Number:
AG00AKVE
Chemical Name:
1H-indol-2-ol
CAS Number:
16990-73-1
Molecular Formula:
C8H7NO
Molecular Weight:
133.1473
MDL Number:
MFCD00005711
IUPAC Name:
1H-indol-2-ol
InChI:
InChI=1S/C8H7NO/c10-8-5-6-3-1-2-4-7(6)9-8/h1-5,9-10H
InChI Key:
JHFAEUICJHBVHB-UHFFFAOYSA-N
SMILES:
Oc1cc2c([nH]1)cccc2
EC Number:
241-069-9
Properties
Complexity:
126
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
133.053g/mol
Formal Charge:
0
Heavy Atom Count:
10
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
133.15g/mol
Monoisotopic Mass:
133.053g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
36A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.4
Literature
| Title | Journal |
|---|---|
| Rhodium(II) catalyzed diastereoselective reactions of diazoacetamides with isatins: an efficient approach to 3-hydroxy-3,3'-bioxindoles. | Organic & biomolecular chemistry 20121128 |
| Enantioselective construction of multifunctionalized spirocyclohexaneoxindoles through organocatalytic Michael-Aldol cyclization of isatin derived alkenes with linear dialdehydes. | Organic & biomolecular chemistry 20121128 |
| Aza-oxindole synthesis via base promoted Truce-Smiles rearrangement. | Chemical communications (Cambridge, England) 20121118 |
| Enantioselective Michael addition of 3-aryloxindoles to a vinyl bisphosphonate ester catalyzed by a cinchona alkaloid derived thiourea catalyst. | Organic & biomolecular chemistry 20121021 |
| Synthesis of oxindolyl pyrazolines and 3-amino oxindole building blocks via a nitrile imine [3 + 2] cycloaddition strategy. | Organic letters 20121019 |
| Facile synthesis of dispirooxindole-fused heterocycles via domino 1,4-dipolar addition and Diels-Alder reaction of in situ generated Huisgen 1,4-dipoles. | Organic letters 20121019 |
| Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancer. | Journal of medicinal chemistry 20120927 |
| Spiro-fused pyrrolidine, piperidine, and oxindole scaffolds from lactams. | Organic letters 20120921 |
| Application of the systems chemistry approach on the ammonolysis of 1-ethoxycarbonyl- and 1-phenoxycarbonyl-3-(2-thienyl)oxindoles. A method to predict reactivity. | The Journal of organic chemistry 20120907 |
| Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer's disease. | Bioorganic & medicinal chemistry letters 20120901 |
| Copper-catalyzed domino coupling reaction: an efficient method to synthesize oxindoles. | Organic & biomolecular chemistry 20120821 |
| Enantioselective construction of 3-hydroxy oxindoles via decarboxylative addition of β-ketoacids to isatins. | Organic letters 20120803 |
| Synthesis, characterization and in vitro antimicrobial evaluation of new compounds incorporating oxindole nucleus. | Journal of enzyme inhibition and medicinal chemistry 20120801 |
| Enamino-oxindole HIV protease inhibitors. | Bioorganic & medicinal chemistry letters 20120801 |
| Multicomponent reaction to construct spirocyclic oxindoles with a Michael (triple Michael)/cyclization cascade sequence as the key step. | Chemistry (Weinheim an der Bergstrasse, Germany) 20120727 |
| Strategies for the enantioselective synthesis of spirooxindoles. | Organic & biomolecular chemistry 20120721 |
| Enantioselective synthesis of 3,3'-dihydropyrryl-spirooxindoles via an organocatalytic three-component reaction. | Organic & biomolecular chemistry 20120721 |
| Organocatalytic enantioselective stereoablative hydroxylation of 3-halooxindoles: an effective method for the construction of enantioenriched 3-substituted 3-hydroxy-2-oxindoles. | Chemistry (Weinheim an der Bergstrasse, Germany) 20120716 |
| Catalytic asymmetric synthesis of spirooxindoles by a mannich-type reaction of isothiocyanato oxindoles. | Angewandte Chemie (International ed. in English) 20120709 |
| Diastereodivergent synthesis of 3-spirocyclopropyl-2-oxindoles through direct enantioselective cyclopropanation of oxindoles. | Chemistry (Weinheim an der Bergstrasse, Germany) 20120702 |
| Catalytic asymmetric exo'-selective [3+2] cycloaddition for constructing stereochemically diversified spiro[pyrrolidin-3,3'-oxindole]s. | Chemistry (Weinheim an der Bergstrasse, Germany) 20120702 |
| Enantioselective Michael addition of 3-aryl-substituted oxindoles to methyl vinyl ketone catalyzed by a binaphthyl-modified bifunctional organocatalyst. | Molecules (Basel, Switzerland) 20120618 |
| Catalytic asymmetric sulfenylation of unprotected 3-substituted oxindoles. | Organic letters 20120601 |
| Bicyclic guanidine-catalyzed asymmetric Michael additions of 3-benzyl-substituted oxindoles to N-maleimides. | Chemical communications (Cambridge, England) 20120525 |
| Organocatalytic asymmetric conjugate addition of 3-monosubstituted oxindoles to (E)-1,4-diaryl-2-buten-1,4-diones: a strategy for the indirect enantioselective furanylation and pyrrolylation of 3-alkyloxindoles. | Chemistry (Weinheim an der Bergstrasse, Germany) 20120521 |
| Phenyliodine bis(trifluoroacetate)-mediated oxidative C-C bond formation: synthesis of 3-hydroxy-2-oxindoles and spirooxindoles from anilides. | Organic letters 20120504 |
| Access to spirocyclic oxindoles via N-heterocyclic carbene-catalyzed reactions of enals and oxindole-derived α,β-unsaturated imines. | Organic letters 20120504 |
| A novel class of sugar-based ether-linked-dispirooxindolo-pyrrolidines/pyrrolizidines through [3+2]-cycloaddition of azomethine ylides. | Carbohydrate research 20120501 |
| Intramolecular 1,3-dipolar cycloaddition reactions in the synthesis of complex annelated quinolines, α-carbolines and coumarins. | Molecular diversity 20120501 |
| Synthesis of novel spirooxindole derivatives by one pot multicomponent reaction and their antimicrobial activity. | European journal of medicinal chemistry 20120501 |
| A catalytic metal-free Ritter reaction to 3-substituted 3-aminooxindoles. | Organic & biomolecular chemistry 20120428 |
| Ionic nucleophilic catalysis of chiral ammonium betaines for highly stereoselective aldol reaction from oxindole-derived vinylic carbonates. | Journal of the American Chemical Society 20120425 |
| Catalytic stereoselective synthesis of diverse oxindoles and spirooxindoles from isatins. | ACS combinatorial science 20120409 |
| Zinc-mediated diastereoselective synthesis of 3-amino oxindoles by addition of methyl and terminal alkynes to N-tert-butanesulfinyl ketimines. | The Journal of organic chemistry 20120406 |
| Ring enlargement versus selenoetherification on the reaction of allenyl oxindoles with selenenylating reagents. | The Journal of organic chemistry 20120406 |
| Aza-oxindole synthesis by oxidative coupling of C(sp2)-H and C(sp3)-H centers. | Chemical communications (Cambridge, England) 20120325 |
| Palladium-catalyzed amidation by chemoselective C(sp3)-H activation: concise route to oxindoles using a carbamoyl chloride precursor. | Angewandte Chemie (International ed. in English) 20120312 |
| Asymmetric synthesis of allenyl oxindoles and spirooxindoles by a catalytic enantioselective Saucy-Marbet Claisen rearrangement. | Angewandte Chemie (International ed. in English) 20120305 |
| N-Heterocyclic carbene-catalyzed three-component domino reaction of alkynyl aldehydes with oxindoles. | Organic letters 20120302 |
| Efficient synthesis of multicyclic spirooxindoles via a cascade Michael/Michael/oxa-Michael reaction of curcumins and isatylidene malononitriles. | Organic & biomolecular chemistry 20120227 |
| Asymmetric assembly of 2-oxindole and α-angelica lactone units to construct vicinal quaternary chiral centers. | Chemical communications (Cambridge, England) 20120227 |
| Development of a nano-electrospray MSn method for the analysis of serotonin and related compounds in urine using a LTQ-orbitrap mass spectrometer. | Talanta 20120215 |
| Facile synthesis of azaarene-substituted 3-hydroxy-2-oxindoles via Brønsted acid catalyzed sp3 C-H functionalization. | Organic letters 20120203 |
| The Arabidopsis concentration-dependent influx/efflux transporter ABCB4 regulates cellular auxin levels in the root epidermis. | The Plant journal : for cell and molecular biology 20120201 |
| Spiro[pyrrolidine-2,3'-oxindole] derivatives synthesized by novel regionselective 1,3-dipolar cycloadditions. | Molecular diversity 20120201 |
| Building addressable libraries: amino acid derived fluorescent linkers. | Langmuir : the ACS journal of surfaces and colloids 20120124 |
| Core-structure-oriented asymmetric organocatalytic substitution of 3-hydroxyoxindoles: application in the enantioselective total synthesis of (+)-folicanthine. | Angewandte Chemie (International ed. in English) 20120123 |
| Dioxindole in asymmetric catalytic synthesis: routes to enantioenriched 3-substituted 3-hydroxyoxindoles and the preparation of maremycin A. | Angewandte Chemie (International ed. in English) 20120123 |
| Synthesis of oxindoles via visible light photoredox catalysis. | Organic & biomolecular chemistry 20120121 |
| Highly efficient and stereoselective construction of dispiro-[oxazolidine-2-thione]bisoxindoles and dispiro[imidazolidine-2-thione]bisoxindoles. | Organic letters 20120120 |
| Asymmetric hydroxyamination of oxindoles catalyzed by chiral bifunctional tertiary amine thiourea: construction of 3-amino-2-oxindoles with quaternary stereocenters. | Organic & biomolecular chemistry 20120114 |
| Enantioselective organocatalytic oxyamination of unprotected 3-substituted oxindoles. | Organic & biomolecular chemistry 20120114 |
| Synthesis of highly functionalized chiral 3,3'-disubstituted oxindoles via an organocatalytic enantioselective Michael addition of nitroalkanes to indolylidenecyanoacetates. | Organic letters 20120106 |
| HPLC analysis of oxindole alkaloids in Uncaria tomentosa: sample preparation and analysis optimisation by factorial design. | Phytochemical analysis : PCA 20120101 |
| Comparative study of fourteen alkaloids from Uncaria rhynchophylla hooks and leaves using HPLC-diode array detection-atmospheric pressure chemical ionization/MS method. | Chemical & pharmaceutical bulletin 20120101 |
| Overdiagnosis of a typical carcinoid tumor as an adenocarcinoma of the lung: a case report and review of the literature. | World journal of surgical oncology 20120101 |
| Synthesis of a dual functional anti-MDR tumor agent PH II-7 with elucidations of anti-tumor effects and mechanisms. | PloS one 20120101 |
| Ethylene in organic synthesis: a new route to anticholenergic pyrrolidinoindolines, and other molecules with all carbon-quaternary centers via asymmetric hydrovinylation. | Organic letters 20111216 |
| Catalytic asymmetric construction of spirocyclopentaneoxindoles by a combined Ru-catalyzed cross-metathesis/double Michael addition sequence. | Organic letters 20111202 |
| Highly enantioselective one-pot synthesis of spirocyclopentaneoxindoles containing the oxime group by organocatalyzed Michael addition/ISOC/fragmentation sequence. | Organic letters 20111202 |
| Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents. | European journal of medicinal chemistry 20111201 |
| Binding of oxindole-Schiff base copper(II) complexes to DNA and its modulation by the ligand. | Journal of inorganic biochemistry 20111201 |
| Pericyclic cascade with chirality transfer: reaction pathway and origin of enantioselectivity of the hetero-Claisen approach to oxindoles. | Angewandte Chemie (International ed. in English) 20111125 |
| Synthesis and stereochemical determination of complestatin A and B (neuroprotectin A and B). | Journal of the American Chemical Society 20111116 |
| Polarized IR spectra of the hydrogen bond in two different oxindole polymorphs with cyclic dimers in their lattices. | The journal of physical chemistry. A 20111110 |
| Development of an LC-MS/MS method for the analysis of serotonin and related compounds in urine and the identification of a potential biomarker for attention deficit hyperactivity/hyperkinetic disorder. | Analytical and bioanalytical chemistry 20111101 |
| Trifluoroacetic acid-promoted synthesis of 3-hydroxy, 3-amino and spirooxindoles from α-keto-N-anilides. | Organic letters 20111021 |
| Diastereo- and enantioselective conjugate addition of 3-substituted oxindoles to nitroolefins catalyzed by a chiral Ni(OAc)2-diamine complex under mild conditions. | Organic letters 20111007 |
| Receptor-based QSAR study for a series of 3,3-disubstituted-5-aryl oxindoles and 6-aryl benzimidazol-2-ones derivatives as progesterone receptor inhibitors. | SAR and QSAR in environmental research 20111001 |
| Catalytic enantioselective total synthesis of hodgkinsine B. | Angewandte Chemie (International ed. in English) 20110919 |
| Enantioselective Michael/cyclization reaction sequence: scaffold-inspired synthesis of spirooxindoles with multiple stereocenters. | Angewandte Chemie (International ed. in English) 20110919 |
| Chiral counteranion synergistic organocatalysis under high temperature: efficient construction of optically pure spiro[cyclohexanone-oxindole] backbone. | Organic letters 20110916 |
| Ultrasound promoted clay catalyzed efficient and one pot synthesis of substituted oxindoles. | Ultrasonics sonochemistry 20110901 |
| Ligand polarizability contributes to tau fibril binding affinity. | Bioorganic & medicinal chemistry 20110901 |
| Asymmetric decarboxylative allylation of oxindoles. | Organic letters 20110819 |
| Addition of TMSCN to chiral ketimines derived from isatin. Synthesis of an oxindole-based peptidomimetic and a bioactive spirohydantoin. | Organic & biomolecular chemistry 20110807 |
| Rauniticine-allo-oxindole B and rauniticinic-allo acid B, new heteroyohimbine-type oxindole alkaloids from the stems of Malaysian Uncaria longiflora var. pteropoda. | Molecules (Basel, Switzerland) 20110804 |
| Continuous-flow synthesis of 3,3-disubstituted oxindoles by a palladium-catalyzed α-arylation/alkylation sequence. | Angewandte Chemie (International ed. in English) 20110704 |
| Syntheses of spirocyclic oxindole-butenolides by using three-component cycloadditions of isocyanides, allenoates, and isatins. | Chemistry (Weinheim an der Bergstrasse, Germany) 20110627 |
| Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thiourea. | Chemical communications (Cambridge, England) 20110621 |
| Directed oxidative cyclizations to C2- or C4-positions of indole: efficient construction of the bicyclo[4.3.1]decane core of welwitindolinones. | Organic letters 20110617 |
| Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain. | Bioorganic & medicinal chemistry letters 20110615 |
| Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties. | Bioorganic & medicinal chemistry letters 20110615 |
| Electron density of two bioactive oligocyclic indole and oxindole derivatives obtained from low-order X-ray data and invariom application. | Chemistry, an Asian journal 20110606 |
| Synthesis and anticancer activity of oxindole derived imidazo[1,5-a]pyrazines. | European journal of medicinal chemistry 20110601 |
| Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst. | Nature chemistry 20110601 |
| Amino-indanol-catalyzed asymmetric Michael additions of oxindoles to protected 2-amino-1-nitroethenes for the synthesis of 3,3'-disubstituted oxindoles bearing α,β-diamino functionality. | The Journal of organic chemistry 20110520 |
| Iodo-carbocyclization of electron-deficient alkenes: synthesis of oxindoles and spirooxindoles. | Organic letters 20110506 |
| The neurotransmitter serotonin interrupts α-synuclein amyloid maturation. | Biochimica et biophysica acta 20110501 |
| Network modeling of MDM2 inhibitor-oxaliplatin combination reveals biological synergy in wt-p53 solid tumors. | Oncotarget 20110501 |
| A [3+2] dipolar cycloaddition route to 3-hydroxy-3-alkyl oxindoles: an approach to pyrrolidinoindoline alkaloids. | Organic letters 20110415 |
| Rhodium(II) acetate-catalyzed stereoselective synthesis, SAR and anti-HIV activity of novel oxindoles bearing cyclopropane ring. | European journal of medicinal chemistry 20110401 |
| Flexible strategy for syntheses of spirooxindoles using palladium-catalyzed carbosilylation and Sakurai-type cyclization. | Organic letters 20110401 |
| Chiral calcium VAPOL phosphate mediated asymmetric chlorination and Michael reactions of 3-substituted oxindoles. | Journal of the American Chemical Society 20110316 |
| Oxindole derivatives as inhibitors of TAK1 kinase. | Bioorganic & medicinal chemistry letters 20110315 |
| Catalytic thia-Sommelet-Hauser rearrangement: application to the synthesis of oxindoles. | Organic letters 20110304 |
| Molybdenum-catalyzed asymmetric allylic alkylation of 3-alkyloxindoles: reaction development and applications. | Chemistry (Weinheim an der Bergstrasse, Germany) 20110301 |
| Organocatalytic Michael-alkylation cascade: the enantioselective nitrocyclopropanation of oxindoles. | Chemistry (Weinheim an der Bergstrasse, Germany) 20110301 |
| Highly enantioselective catalytic benzoyloxylation of 3-aryloxindoles using chiral VAPOL calcium phosphate. | Angewandte Chemie (International ed. in English) 20110201 |
| Different biochemical correlates for different neuropsychiatric abnormalities in patients with cirrhosis. | Hepatology (Baltimore, Md.) 20110201 |
| Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla. | Journal of natural products 20110128 |
| Enantioselective Morita-Baylis-Hillman reaction of isatins with acrylates: facile creation of 3-hydroxy-2-oxindoles. | Organic letters 20110107 |
| Indole and 3-indolylacetonitrile inhibit spore maturation in Paenibacillus alvei. | BMC microbiology 20110101 |
| Synthesis and crystal structures of 5'-phenylspiro[indoline-3, 2'-pyrrolidin]-2-one derivatives. | Chemistry Central journal 20110101 |
| Neuroendocrine tumors of the gallbladder: a case report and review of the literature. | Journal of medical case reports 20110101 |
| Asymmetric conjugate addition of oxindoles to 2-chloroacrylonitrile: a highly effective organocatalytic strategy for simultaneous construction of 1,3-nonadjacent stereocenters leading to chiral pyrroloindolines. | Chemistry (Weinheim an der Bergstrasse, Germany) 20101227 |
| Indolyne experimental and computational studies: synthetic applications and origins of selectivities of nucleophilic additions. | Journal of the American Chemical Society 20101222 |
| Highly enantioselective organocatalytic α-amination reactions of aryl oxindoles: developing designer multifunctional alkaloid catalysts. | Organic letters 20101217 |
| Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20101201 |
| A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of novel spiro-pyrrolothiazolyloxindoles and their antitubercular evaluation. | European journal of medicinal chemistry 20101201 |
| Role of (68)Ga-DOTATOC PET/CT in the evaluation of primary pulmonary carcinoids. | The Korean journal of internal medicine 20101201 |
| A myosin V inhibitor based on privileged chemical scaffolds. | Angewandte Chemie (International ed. in English) 20101102 |
| Palladium-catalyzed carbo-heterofunctionalization of alkenes for the synthesis of oxindoles and spirooxindoles. | Organic letters 20101015 |
| Palladium-catalyzed tandem diperoxidation/C-H activation resulting in diperoxy-oxindole in air. | Organic letters 20101015 |
| Stereocontrolled creation of all-carbon quaternary stereocenters by organocatalytic conjugate addition of oxindoles to vinyl sulfone. | Angewandte Chemie (International ed. in English) 20101011 |
| Organocatalytic and electrophilic approach to oxindoles with C3-quaternary stereocenters. | Organic letters 20101001 |
| Copper-catalyzed asymmetric addition of arylboronates to isatins: a catalytic cycle involving alkoxocopper intermediates. | Chemical communications (Cambridge, England) 20100928 |
| The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists. | Bioorganic & medicinal chemistry letters 20100915 |
| A facile method for the synthesis of oxindole based quaternary alpha-aminonitriles via the Strecker reaction. | Organic & biomolecular chemistry 20100907 |
| Melatonin metabolism in the central nervous system. | Current neuropharmacology 20100901 |
| Synthesis, electrochemical studies and anticancer activity of ferrocenyl oxindoles. | Dalton transactions (Cambridge, England : 2003) 20100821 |
| Branch-selective synthesis of oxindole and indene scaffolds: transition metal-controlled intramolecular aryl amidation leading to c3 reverse-prenylated oxindoles. | Organic letters 20100820 |
| First C-H activation route to oxindoles using copper catalysis. | Organic letters 20100806 |
| Highly enantioselective construction of spiro[4H-pyran-3,3'-oxindoles] through a domino Knoevenagel/Michael/cyclization sequence catalyzed by cupreine. | Organic letters 20100716 |
| Organocatalytic enantioselective hydroxymethylation of oxindoles with paraformaldehyde as C1 unit. | The Journal of organic chemistry 20100716 |
| Highly diastereo- and enantioselective Michael additions of 3-substituted oxindoles to maleimides catalyzed by chiral bifunctional thiourea-tertiary amine. | Organic letters 20100702 |
| Synthesis and structure-activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors. | Bioorganic & medicinal chemistry 20100701 |
| Organocatalytic Michael addition of unprotected 3-substituted oxindoles to nitroolefins. | Organic & biomolecular chemistry 20100628 |
| Highly enantioselective synthesis of 3-amino-2-oxindole derivatives: catalytic asymmetric alpha-amination of 3-substituted 2-oxindoles with a chiral scandium complex. | Chemistry (Weinheim an der Bergstrasse, Germany) 20100611 |
| Oxidative dearomatization in the synthesis of erythrina, oxindole and hexahydropyrrolo[2,3-b]indole skeletons. | Chemical communications (Cambridge, England) 20100607 |
| Peripheral and splanchnic indole and oxindole levels in cirrhotic patients: a study on the pathophysiology of hepatic encephalopathy. | The American journal of gastroenterology 20100601 |
| Synthesis of notoamide J: a potentially pivotal intermediate in the biosynthesis of several prenylated indole alkaloids. | The Journal of organic chemistry 20100507 |
| Six-component reactions for the stereoselective synthesis of 3-arylidene-2-oxindoles via sequential one-pot Ugi/Heck carbocyclization/Sonogashira/nucleophilic addition. | The Journal of organic chemistry 20100507 |
| Dimeric quinidine-catalyzed enantioselective aminooxygenation of oxindoles: an organocatalytic approach to 3-hydroxyoxindole derivatives. | Journal of the American Chemical Society 20100428 |
| An efficient stereoselective synthesis of 3-spirocyclopentene- and 3-spiropyrazole-2-oxindoles via 1,3-dipolar cycloaddition reaction. | Chemical communications (Cambridge, England) 20100428 |
| Oxindole synthesis by palladium-catalysed aromatic C-H alkenylation. | Chemical communications (Cambridge, England) 20100414 |
| 1'-(2-Chloro-phen-yl)-5,6,5',6',7',7a'-hexa-hydro-1'H,1''H-dispiro-[imidazo[2,1-b][1,3]thia-zole-2,2'-pyrrolizine-3'(2'H),3''-indole]-2'',3(2H,3''H)-dione. | Acta crystallographica. Section E, Structure reports online 20100401 |
| Catalytic asymmetric synthesis of 3-(alpha-hydroxy-beta-carbonyl) oxindoles by a Sc(III)-catalyzed direct aldol-type reaction. | Chemistry (Weinheim an der Bergstrasse, Germany) 20100322 |
| Predictive comparative QSAR modelling of (phenylpiperazinyl-alkyl) oxindoles as selective 5-HT1A antagonists by stepwise regression, PCRA, FA-MLR and PLS techniques. | European journal of medicinal chemistry 20100301 |
| Organocatalytic tandem reaction to construct six-membered spirocyclic oxindoles with multiple chiral centres through a formal [2+2+2] annulation. | Chemistry (Weinheim an der Bergstrasse, Germany) 20100301 |
| Catalytic asymmetric synthesis of 3-aminooxindoles: enantiofacial selectivity switch in bimetallic vs monometallic Schiff base catalysis. | Journal of the American Chemical Society 20100203 |
| Catalytic double stereoinduction in asymmetric allylic alkylation of oxindoles. | Chemistry (Weinheim an der Bergstrasse, Germany) 20100104 |
| Catalytic asymmetric synthesis of substituted 3-hydroxy-2-oxindoles. | Angewandte Chemie (International ed. in English) 20100101 |
| Double-detargeted oncolytic adenovirus shows replication arrest in liver cells and retains neuroendocrine cell killing ability. | PloS one 20100101 |
| Covalent anchoring of chloroperoxidase and glucose oxidase on the mesoporous molecular sieve SBA-15. | International journal of molecular sciences 20100101 |
| Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor. | PloS one 20100101 |
| Enantioselective synthesis of substituted oxindoles and spirooxindoles with applications in drug discovery. | Current opinion in drug discovery & development 20100101 |
| (5''E)-1''-Benzyl-1'-methyl-5''-[4-(methyl-sulfan-yl)benzyl-idene]-4'-[4-(methyl-sulfan-yl)phen-yl]dispiro-[indoline-3,2'-pyrrolidine-3',3''-piperidine]-2,4''-dione dichloro-methane solvate. | Acta crystallographica. Section E, Structure reports online 20100101 |
| Pitfalls in neuroendocrine tumor diagnosis. | Rare tumors 20091228 |
| Expanding the scope of cinchona alkaloid-catalyzed enantioselective alpha-aminations of oxindoles: a versatile approach to optically active 3-amino-2-oxindole derivatives. | The Journal of organic chemistry 20091204 |
| Asymmetric construction of quaternary stereocenters by direct organocatalytic amination of 3-substituted oxindoles. | Chemical communications (Cambridge, England) 20091128 |
| (E)-3-(2,6-Dichloro-benzyl-idene)indolin-2-one. | Acta crystallographica. Section E, Structure reports online 20091101 |
| Functionalization and rearrangement of spirocyclohexadienyl oxindoles: experimental and theoretical investigations. | Chemistry (Weinheim an der Bergstrasse, Germany) 20091026 |
| Oxindole-Schiff base copper(II) complexes interactions with human serum albumin: spectroscopic, oxidative damage, and computational studies. | Journal of inorganic biochemistry 20091001 |
| Organocatalytic synthesis of spiro[pyrrolidin-3,3'-oxindoles] with high enantiopurity and structural diversity. | Journal of the American Chemical Society 20090930 |
| Selective synthesis of 3-aryl quinolin-2(1H)-ones and 3-(1-arylmethylene)oxindoles involving a 2-fold arene C-H activation process. | The Journal of organic chemistry 20090904 |
| Highly enantioselective and organocatalytic alpha-amination of 2-oxindoles. | Organic letters 20090903 |
| Midgut neuroendocrine tumours with liver metastases: results of the UKINETS study. | Endocrine-related cancer 20090901 |
| (E)-5-Bromo-3-(2,6-dichloro-benzyl-idene)indolin-2-one. | Acta crystallographica. Section E, Structure reports online 20090901 |
| Access to a welwitindolinone core using sequential cycloadditions. | Organic letters 20090820 |
| Efficient synthesis of 3,3-diheteroaromatic oxindole analogues and their in vitro evaluation for spermicidal potential. | Bioorganic & medicinal chemistry letters 20090815 |
| Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative. | Bioorganic & medicinal chemistry 20090815 |
| Stereoselective synthesis of spirocyclic oxindoles via Prins cyclizations. | Organic letters 20090806 |
| Stereocontrolled synthesis of spirooxindoles through Lewis acid-promoted [5 + 2]-annulation of chiral silyl alcohols. | Organic letters 20090806 |
| Antioxidant potential study of some synthesized N-heterocycles. | Bangladesh Medical Research Council bulletin 20090801 |
| Direct N-carbamoylation of 3-monosubstituted oxindoles with alkyl imidazole carboxylates. | The Journal of organic chemistry 20090717 |
| Organocatalytic asymmetric allylic alkylation of oxindoles with Morita-Baylis-Hillman carbonates. | Chemical communications (Cambridge, England) 20090714 |
| A homodinuclear Mn(III)2-Schiff base complex for catalytic asymmetric 1,4-additions of oxindoles to nitroalkenes. | Journal of the American Chemical Society 20090708 |
| Thiourea-catalyzed highly enantio- and diastereoselective additions of oxindoles to nitroolefins: application to the formal synthesis of (+)-physostigmine. | Journal of the American Chemical Society 20090701 |
| Soluble, semivolatile phenol and nitrogen compounds in milk-processing wastewaters. | Journal of dairy science 20090701 |
| Differences in CYP3A4 catalyzed bioactivation of 5-aminooxindole and 5-aminobenzsultam scaffolds in proline-rich tyrosine kinase 2 (PYK2) inhibitors: retrospective analysis by CYP3A4 molecular docking, quantum chemical calculations and glutathione adduct detection using linear ion trap/orbitrap mass spectrometry. | Bioorganic & medicinal chemistry letters 20090615 |
| Oxindole synthesis by direct C-H, Ar-H coupling. | Chemical communications (Cambridge, England) 20090614 |
| Concise synthesis of the bicyclic scaffold of N-methylwelwitindolinone C isothiocyanate via an indolyne cyclization. | Organic letters 20090604 |
| Four tetracyclic oxindole alkaloids and a taberpsychine derivative from a Malayan Tabernaemontana. | Phytochemistry 20090601 |
| 5-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials. | Journal of clinical medicine research 20090601 |
| Enantioselective synthesis of SM-130686 based on the development of asymmetric Cu(I)F catalysis to access 2-oxindoles containing a tetrasubstituted carbon. | Journal of the American Chemical Society 20090527 |
| Ruthenium-catalyzed alkylation of oxindole with alcohols. | The Journal of organic chemistry 20090515 |
| Ugi-post functionalization, from a single set of ugi-adducts to two distinct heterocycles by microwave-assisted palladium-catalyzed cyclizations: tuning the reaction pathways by ligand switch. | The Journal of organic chemistry 20090417 |
| The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain. | Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20090412 |
| Synthesis of oxindoles by tandem Heck-reduction-cyclization (HRC) from a single bifunctional, in situ generated Pd/C catalyst. | The Journal of organic chemistry 20090206 |
| (Z)-3-[(E)-3-Phenyl-allyl-idene]indolin-2-one. | Acta crystallographica. Section E, Structure reports online 20090201 |
| rac-(4R,17S,18R,26R)-Ethyl 4'-methoxy-carbonyl-5''-(4-methoxy-phen-yl)-1'-methyl-2,3''-dioxo-2'',3''-dihydro-indoline-3-spiro-2'-pyrrolidine-3'-spiro-2''-thia-zolo[3,2-a]pyrimidine-6''-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20090201 |
| AcOLeDMAP and BnOLeDMAP: conformationally restricted nucleophilic catalysts for enantioselective rearrangement of indolyl acetates and carbonates. | Journal of the American Chemical Society 20090114 |
| The discovery of highly potent CGRP receptor antagonists. | Bioorganic & medicinal chemistry letters 20090101 |
| Oxindole synthesis by direct coupling of C(sp2)-H and C(sp3)-H centers. | Angewandte Chemie (International ed. in English) 20090101 |
| Targeting structural and stereochemical complexity by organocascade catalysis: construction of spirocyclic oxindoles having multiple stereocenters. | Angewandte Chemie (International ed. in English) 20090101 |
| Catalytic enantioselective stereoablative alkylation of 3-halooxindoles: facile access to oxindoles with C3 all-carbon quaternary stereocenters. | Angewandte Chemie (International ed. in English) 20090101 |
| A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replication. | BMC microbiology 20090101 |
| Stereoselective synthesis of 3-alkylideneoxindoles by palladium-catalyzed cyclization reaction of 2-(alkynyl)aryl isocyanates with organoboron reagents. | Organic letters 20081106 |
| (13)C, (15)N CPMAS NMR and GIAO DFT calculations of stereoisomeric oxindole alkaloids from Cat's Claw (Uncaria tomentosa). | Solid state nuclear magnetic resonance 20081101 |
| Rearrangement of spirocyclic oxindoles with lithium amide bases. | Organic letters 20081016 |
| Diazonamide support studies: stereoselective formation of the C10 chiral center in both the CDEFG and AEFG fragments. | Organic letters 20080918 |
| Stereoselective oxidative rearrangement of 2-aryl tryptamine derivatives. | Organic letters 20080918 |
| Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis. | Chemical communications (Cambridge, England) 20080914 |
| Intermolecular enolate heterocoupling: scope, mechanism, and application. | Journal of the American Chemical Society 20080827 |
| Organocatalytic stereoselective mannich reaction of 3-substituted oxindoles. | Organic letters 20080821 |
| Enantioselective synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed cyanoamidation. | Organic letters 20080807 |
| Orthogonal Pd- and Cu-based catalyst systems for C- and N-arylation of oxindoles. | Journal of the American Chemical Society 20080723 |
| Palladium-catalyzed C-H functionalization of N-arylpropiolamides with aryliodonium salts: selective synthesis of 3-(1-arylmethylene)oxindoles. | The Journal of organic chemistry 20080718 |
| Facile and general synthesis of quaternary 3-aminooxindoles. | Organic letters 20080703 |
| Synthesis of (2-oxoindolin-3-ylidene)methyl acetates involving a C-H functionalization process. | Organic letters 20080501 |
| Palladium-catalyzed alpha-arylation of oxindoles. | Organic letters 20080403 |
| Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348). | Journal of medicinal chemistry 20080327 |
| Double-strand DNA cleavage induced by oxindole-Schiff base copper(II) complexes with potential antitumor activity. | Journal of inorganic biochemistry 20080101 |
| Biotransformation of indole derivatives by mycelial cultures. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20080101 |
| Palladium-catalyzed tandem Heck reaction/C-H functionalization--preparation of spiro-indane-oxindoles. | Angewandte Chemie (International ed. in English) 20080101 |
| Design and synthesis of novel oxindoles as potential non-nucleosidic reverse transcriptase inhibitors against HIV. | Nucleic acids symposium series (2004) 20080101 |
| Mo-catalyzed regio-, diastereo-, and enantioselective allylic alkylation of 3-aryloxindoles. | Journal of the American Chemical Society 20071128 |
| Potent oxindole based human beta3 adrenergic receptor agonists. | Bioorganic & medicinal chemistry letters 20071115 |
| Enantioselective construction of spirocyclic oxindolic cyclopentanes by palladium-catalyzed trimethylenemethane-[3+2]-cycloaddition. | Journal of the American Chemical Society 20071017 |
| Synthesis of novel functionalized 3-spiropyrrolizidine and 3-spiropyrrolidine oxindoles from Baylis-Hillman adducts of isatin and heteroaldehydes with azomethine ylides via [3+2]-cycloaddition. | Organic letters 20071011 |
| [Association between the TPH2 gene and suicidal behavior]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20071001 |
| The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. | FEBS letters 20070918 |
| Straightforward stereoselective synthesis of spiro-epoxyoxindoles. | Organic letters 20070426 |
| Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20070401 |
| Polyhydroxylated indolines and oxindoles from C-glycosides via sequential Henry reaction, Michael addition, and reductive amination/amidation. | The Journal of organic chemistry 20070330 |
| Isatinones A and B, new antifungal oxindole alkaloids from Isatis costata. | Molecules (Basel, Switzerland) 20070206 |
| Structure-activity relationship study of oxindole-based inhibitors of cyclin-dependent kinases based on least-squares support vector machines. | Analytica chimica acta 20070109 |
| Simple and one-pot protocol for synthesis of indene-spiro-oxindoles involving tandem Prins and Friedel-Crafts reactions. | Organic letters 20070104 |
| 3D-QSAR CoMFA study on oxindole derivatives as cyclin dependent kinase 1 (CDK1) and cyclin dependent kinase 2 (CDK2) inhibitors. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20070101 |
| A traceless approach for the solid-phase parallel synthesis of trisubstituted oxindoles. | Journal of combinatorial chemistry 20070101 |
| Cinchona-alkaloid-catalyzed enantioselective direct aldol-type reaction of oxindoles with ethyl trifluoropyruvate. | Angewandte Chemie (International ed. in English) 20070101 |
| Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain. | Journal of neural transmission. Supplementum 20070101 |
| Lewis acid-catalyzed enantioselective hydroxylation reactions of oxindoles and beta-keto esters using DBFOX ligand. | Journal of the American Chemical Society 20061227 |
| Enantioselective arylation of 2-methylacetoacetates catalyzed by CuI/trans-4-hydroxy-L-proline at low reaction temperatures. | Journal of the American Chemical Society 20061220 |
| Efficient asymmetric synthesis of novel gastrin receptor antagonist AG-041R via highly stereoselective alkylation of oxindole enolates. | The Journal of organic chemistry 20061027 |
| An efficient synthesis of a spirocyclic oxindole analogue. | Molecules (Basel, Switzerland) 20060914 |
| Solid phase approaches to N-heterocycles using a sulfur linker cleaved by SmI2. | The Journal of organic chemistry 20060818 |
| Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers. | Bioorganic & medicinal chemistry letters 20060701 |
| Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives. | Biochemistry 20060418 |
| Selective kinase inhibition by exploiting differential pathway sensitivity. | Chemistry & biology 20060401 |
| Diastereoselection in the formation of spirocyclic oxindoles by the intramolecular Heck reaction. | The Journal of organic chemistry 20060331 |
| Highly diastereoselective one-pot synthesis of spirocyclic oxindoles through intramolecular Ullmann coupling and Claisen rearrangement. | Angewandte Chemie (International ed. in English) 20060327 |
| Synthesis of the putative structure of fistulosin using the ruthenium-catalyzed cycloisomerization of diene. | The Journal of organic chemistry 20060203 |
| Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents. | Journal of medicinal chemistry 20060126 |
| A new chemical tool for exploring the physiological function of the PDE2 isozyme. | Bioorganic & medicinal chemistry letters 20060115 |
| Liver metastases of neuroendocrine tumours; early reduction of tumour load to improve life expectancy. | World journal of surgical oncology 20060101 |
| Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40). | Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101 |
| A novel method for observing proteins in vivo using a small fluorescent label and multiphoton imaging. | The Biochemical journal 20050915 |
| Stereoselective synthesis of 3-alkylideneoxindoles via palladium-catalyzed domino reactions. | The Journal of organic chemistry 20050819 |
| Antiangiogenic drugs synergize with a membrane macrophage colony-stimulating factor-based tumor vaccine to therapeutically treat rats with an established malignant intracranial glioma. | Journal of immunology (Baltimore, Md. : 1950) 20050301 |
| Recent developments on KCNQ potassium channel openers. | Current medicinal chemistry 20050101 |
| Palladium-catalyzed asymmetric allylation of prochiral nucleophiles: synthesis of 3-allyl-3-aryl oxindoles. | Angewandte Chemie (International ed. in English) 20041227 |
| Involvement of photooxidation of melanogenic precursors in prolonged pigmentation induced by ultraviolet A. | The Journal of investigative dermatology 20040201 |
| [Effects of 3-substituted aryl oxindole(PH II-7) on cell cycle of tumor cells]. | Yao xue xue bao = Acta pharmaceutica Sinica 20031101 |
| Prooxidant activity of free radicals derived from phenol-containing neurotransmitters. | Toxicology 20020801 |
| Efficient formal total synthesis of physostigmine and physovenine: conformational analysis of key intermediates. | Journal of natural products 20020201 |
| [Effect of oxidized indoles on monoamine oxidase activity in the rat brain mitochondria]. | Voprosy meditsinskoi khimii 20020101 |
| Expression of the Caldariomyces fumago chloroperoxidase in Aspergillus niger and characterization of the recombinant enzyme. | The Journal of biological chemistry 20010525 |
| Chloroperoxidase-catalyzed enantioselective oxidations in hydrophobic organic media. | Biotechnology and bioengineering 20010305 |
| Crystal structure of a conformation-selective casein kinase-1 inhibitor. | The Journal of biological chemistry 20000630 |
| Characterization of novel inhibitors of cyclin-dependent kinases. | Biochemical and biophysical research communications 19990714 |
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