200,000+ products from a single source!
sales@angenechem.com
168560-79-0 | 1H-Indene-1,5-dicarboxylic acid, 1-amino-2,3-dihydro-
CAS No: 168560-79-0 Catalog No: AG001Y57 MDL No:
Product Description
Catalog Number:
AG001Y57
Chemical Name:
1H-Indene-1,5-dicarboxylic acid, 1-amino-2,3-dihydro-
CAS Number:
168560-79-0
Molecular Formula:
C11H11NO4
Molecular Weight:
221.2093
IUPAC Name:
1-amino-2,3-dihydroindene-1,5-dicarboxylic acid
InChI:
InChI=1S/C11H11NO4/c12-11(10(15)16)4-3-6-5-7(9(13)14)1-2-8(6)11/h1-2,5H,3-4,12H2,(H,13,14)(H,15,16)
InChI Key:
LSTPKMWNRWCNLS-UHFFFAOYSA-N
SMILES:
OC(=O)c1ccc2c(c1)CCC2(N)C(=O)O
Properties
Complexity:
330
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
221.069g/mol
Formal Charge:
0
Heavy Atom Count:
16
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
221.212g/mol
Monoisotopic Mass:
221.069g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
101A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
-2
Literature
| Title | Journal |
|---|---|
| Activation of amygdalar metabotropic glutamate receptors modulates anxiety, and risk assessment behaviors in ovariectomized estradiol-treated female rats. | Pharmacology, biochemistry, and behavior 20120501 |
| Functional metabotropic glutamate receptors 1 and 5 are expressed in murine podocytes. | Kidney international 20120301 |
| Umami taste in mice uses multiple receptors and transduction pathways. | The Journal of physiology 20120301 |
| Behavioral responses to glutamate receptor agonists and antagonists implicate the involvement of brain-expressed mGluR4 and mGluR1 in taste transduction for umami in mice. | Physiology & behavior 20120201 |
| N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity. | PloS one 20120101 |
| Capsaicin prevents the hyperalgesia induced by peripheral group I mGluRs activation. | Neuroscience letters 20110818 |
| Participation of metabotropic glutamate receptors in pentetrazol-induced kindled seizure. | Epilepsia 20110101 |
| Metabotropic glutamate receptors as a target for anticonvulsant and anxiolytic action in immature rats. | Epilepsia 20100701 |
| Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. | The European journal of neuroscience 20100201 |
| Anticonvulsant effect of (RS)-1-aminoindan-1,5-dicarboxylic acid on pentetrazol-induced kindled seizures in mice. | Biological & pharmaceutical bulletin 20100101 |
| Metabotropic glutamate receptors: potential drug targets for psychiatric disorders. | The open medicinal chemistry journal 20100101 |
| Effects of mGluR5 and mGluR1 antagonists on anxiety-like behavior and learning in developing rats. | Behavioural brain research 20091201 |
| Evidence group I mGluR drugs modulate the activation profile of lipopolysaccharide-exposed microglia in culture. | Neurochemical research 20091001 |
| Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. | Nature neuroscience 20090801 |
| DHPG activation of group 1 mGluRs in BLA enhances fear conditioning. | Learning & memory (Cold Spring Harbor, N.Y.) 20090701 |
| Inhibitory effects of Group I metabotropic glutamate receptors antagonists on the expression of NMDA receptor NR1 subunit in morphine tolerant rats. | Neuroscience letters 20090320 |
| Local antagonism of intertrigeminal region metabotropic glutamate receptors exacerbates apneic responses to intravenous serotonin. | Respiratory physiology & neurobiology 20090227 |
| Effect of the class I metabotropic glutamate receptor antagonist AIDA on certain behaviours in rats with experimental chronic hyperammonemia. | Advances in medical sciences 20090101 |
| Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist. | Bioorganic & medicinal chemistry 20081115 |
| Participation of the cholinergic system in ameliorating effect of vasopressin fragment by group I metabotropic glutamate-receptor blockade. | Journal of pharmacological sciences 20081101 |
| Spinal Metabotropic Glutamate Receptors (mGluRs) are Involved in the Melittin-induced Nociception in Rats. | The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20081001 |
| Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment. | Behavioural brain research 20080805 |
| Face-washing behavior induced by the group I metabotropic glutamate receptor agonist (S)-3,5-DHPG in mice is mediated by mGlu1 receptor. | European journal of pharmacology 20080531 |
| Enantioselective HPLC of potentially CNS-active acidic amino acids with a Cinchona carbamate based chiral stationary phase. | Chirality 20080301 |
| Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats. | Pharmacological research 20080301 |
| Modulation of defensive responses and anxiety-like behaviors by group I metabotropic glutamate receptors located in the dorsolateral periaqueductal gray. | Progress in neuro-psychopharmacology & biological psychiatry 20080101 |
| Modulation by group 1 metabotropic glutamate receptors of depotentiation in the dentate gyrus of freely moving rats. | Hippocampus 20080101 |
| Participation of cholinergic system in memory deficits induced by blockade of hippocampal mGlu(1) receptors. | European journal of pharmacology 20071201 |
| Neurosteroid modulation of neuronal excitability and synaptic transmission in the rat medial vestibular nuclei. | The European journal of neuroscience 20070701 |
| The peripheral role of group I metabotropic glutamate receptors on nociceptive behaviors in rats with knee joint inflammation. | Neuroscience letters 20070412 |
| Modulation of NMDA receptor current in layer V pyramidal neurons of the rat prefrontal cortex by P2Y receptor activation. | Cerebral cortex (New York, N.Y. : 1991) 20070301 |
| Cellular mechanisms of burst firing-mediated long-term depression in rat neocortical pyramidal cells. | The Journal of physiology 20070115 |
| Complex interplay between glutamate receptors and intracellular Ca2+ stores during ischaemia in rat spinal cord white matter. | The Journal of physiology 20061115 |
| Persistent rhythmic oscillations induced by nicotine on neonatal rat hypoglossal motoneurons in vitro. | The European journal of neuroscience 20061101 |
| Protective effect of metabotropic glutamate receptor inhibition on amyotrophic lateral sclerosis-cerebrospinal fluid toxicity in vitro. | Neuroscience 20060915 |
| Group I mGluR regulates the polarity of spike-timing dependent plasticity in substantia gelatinosa neurons. | Biochemical and biophysical research communications 20060825 |
| Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson's disease. | Brain research bulletin 20060414 |
| NMDA and group I metabotropic glutamate receptors activation modulates substance P release from the arcuate nucleus and median eminence. | Neuroscience letters 20060123 |
| Down-regulation of metabotropic glutamate receptor 1alpha in globus pallidus and substantia nigra of parkinsonian monkeys. | The European journal of neuroscience 20051201 |
| Regulation of extracellular glutamate in the prefrontal cortex: focus on the cystine glutamate exchanger and group I metabotropic glutamate receptors. | The Journal of pharmacology and experimental therapeutics 20050701 |
| Metabotropic glutamate receptor antagonist AIDA blocks induction of mossy fiber-CA3 LTP in vivo. | Journal of neurophysiology 20050501 |
| mGlu and NMDA receptor contributions to capsaicin-induced thermal and mechanical hypersensitivity. | Neuropharmacology 20050301 |
| Gq/11-induced and spontaneous waves of coordinated network activation in developing frontal cortex. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050216 |
| Group I and II metabotropic glutamate receptors alter brain cortical metabolic and glutamate/glutamine cycle activity: a 13C NMR spectroscopy and metabolomic study. | Journal of neurochemistry 20050101 |
| Metabotropic glutamate receptors contribute to neocortical synaptic plasticity in vivo. | Neuroreport 20041203 |
| Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling. | Circulation research 20041112 |
| Layer variations of long-term depression in rat visual cortex. | Journal of neurophysiology 20041101 |
| Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis. | Journal of neuropathology and experimental neurology 20040801 |
| Group I and II metabotropic glutamate receptors are necessary for the activity-dependent regulation of ribosomes in chick auditory neurons. | Brain research 20040716 |
| Effects of mGlu1 and mGlu5 metabotropic glutamate antagonists to reverse morphine tolerance in mice. | European journal of pharmacology 20040525 |
| Preparative resolution of 1-aminoindan-1,5-dicarboxylic acid (AIDA) by chiral ligand-exchange chromatography. | Chirality 20040515 |
| The anxiolytic-like activity of AIDA (1-aminoindan-1,5-dicarboxylic acid), an mGLu 1 receptor antagonist. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040301 |
| Group I metabotropic receptor antagonism blocks depletion of calcium stores and reduces potentiated capacitative calcium entry in strain-injured neurons and astrocytes. | Journal of neurotrauma 20040301 |
| Postsynaptic metabotropic glutamate receptor mGluR1 mediates the late component of signal propagation in the guinea pig piriform cortex: optical imaging study. | Neuroscience letters 20040206 |
| Modulation of rhythmic patterns and cumulative depolarization by group I metabotropic glutamate receptors in the neonatal rat spinal cord in vitro. | The European journal of neuroscience 20040201 |
| Antagonism of group I metabotropic glutamate receptors and PLC attenuates increases in inositol trisphosphate and reduces reactive gliosis in strain-injured astrocytes. | Journal of neurotrauma 20040201 |
| Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus. | Hippocampus 20040101 |
| Carotid baroreflex in the rat: role of glutamate receptors in the medial subnucleus of the solitary tract. | Neuroscience 20040101 |
| Hippocampal mGluR1 and consolidation of contextual fear conditioning. | Brain research bulletin 20031115 |
| The striopallidal pathway is involved in antiparkinsonian-like effects of the blockade of group I metabotropic glutamate receptors in rats. | Neuroscience letters 20030515 |
| MPEP, a selective metabotropic glutamate receptor 5 antagonist, attenuates conditioned taste aversion in rats. | Behavioural brain research 20030515 |
| [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. | Molecular pharmacology 20030501 |
| Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030301 |
| Determination of group I metabotropic glutamate receptor subtypes involved in the frequency of epileptiform activity in vitro using mGluR1 and mGluR5 mutant mice. | Neuropharmacology 20030201 |
| Cyclic AMP-mediated regulation of striatal glutamate release: interactions of presynaptic ligand- and voltage-gated ion channels and G-protein-coupled receptors. | Neurochemistry international 20030101 |
| Characteristics of GABA release modified by glutamate receptors in mouse hippocampal slices. | Neurochemistry international 20030101 |
| Morphine induction of c-fos expression in the rat forebrain through glutamatergic mechanisms: role of non-n-methyl-D-aspartate receptors. | Neuroscience 20030101 |
| Influence of AIDA on certain behaviors in rats subjected to experimental hypoxia. | Polish journal of pharmacology 20030101 |
| Role of the flocculus in mediating vestibular nucleus neuron plasticity during vestibular compensation in the rat. | The Journal of physiology 20021215 |
| AIDA, a class I metabotropic glutamate-receptor antagonist limits kainate-induced hippocampal dysfunction. | Epilepsia 20021101 |
| The striatum as a target for anti-rigor effects of an antagonist of mGluR1, but not an agonist of group II metabotropic glutamate receptors. | Brain research 20020920 |
| Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists. | Neuroscience letters 20020920 |
| Impairment of contextual fear conditioning in rats by Group I mGluRs: reversal by the nootropic nefiracetam. | Pharmacology, biochemistry, and behavior 20020901 |
| Antinociceptive effects following intrathecal pretreatment with selective metabotropic glutamate receptor compounds in a rat model of neuropathic pain. | Pharmacology, biochemistry, and behavior 20020901 |
| Activation of mGlu1 but not mGlu5 metabotropic glutamate receptors contributes to postischemic neuronal injury in vitro and in vivo. | Pharmacology, biochemistry, and behavior 20020901 |
| Behavioral evidence supporting a differential role for spinal group I and II metabotropic glutamate receptors in inflammatory hyperalgesia in sheep. | Neuropharmacology 20020901 |
| Group I and II metabotropic glutamate receptors modulate respiratory activity in the lamprey. | The European journal of neuroscience 20020801 |
| The activation of metabotropic glutamate receptors differentially affects GABA and alpha-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats. | Neuroscience letters 20020719 |
| Metabotropic glutamate receptors in the hippocampus and nucleus accumbens are involved in generating seizure-induced hippocampal gamma waves and behavioral hyperactivity. | Behavioural brain research 20020615 |
| Metabotropic glutamate receptors are involved in amygdaloid plasticity. | The European journal of neuroscience 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca(2+) elevation associated with age-dependent excitotoxicity. | Neuroscience 20020101 |
| A new binding mode of competitive antagonists to metabotropic glutamate receptors exemplified by the mGluR1-receptor antagonist AIDA (RS-aminoindan-1,5-dicarboxylic acid). | Doklady. Biochemistry and biophysics 20020101 |
| The role of striatal metabotropic glutamate receptors in Parkinson's disease. | Amino acids 20020101 |
| Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses. | Journal of neurophysiology 20011101 |
| Effects of metabotropic glutamate receptor agonists and antagonists on D-aspartate release from mouse cerebral cortical and striatal slices. | Neurochemical research 20011101 |
| Metabotropic glutamate 1alpha receptors on peripheral primary afferent fibers: their role in nociception. | Brain research 20010914 |
| Group I mGluR antagonist AIDA protects nigral DA cells from MPTP-induced injury. | Neuroreport 20010828 |
| Exogenous glutamate induces short and long-term potentiation in the rat medial vestibular nuclei. | Neuroreport 20010808 |
| Role of metabotropic glutamate receptors in vasopressin and oxytocin release. | American journal of physiology. Regulatory, integrative and comparative physiology 20010801 |
| Induction of long-term depression in cerebellar Purkinje cells requires a rapidly turned over protein. | Journal of neurophysiology 20010701 |
| Endogenous sulphur-containing amino acids: potent agonists at presynaptic metabotropic glutamate autoreceptors in the rat central nervous system. | British journal of pharmacology 20010701 |
| Stimulation of Na-K-2Cl cotransporter in neurons by activation of Non-NMDA ionotropic receptor and group-I mGluRs. | Journal of neurophysiology 20010601 |
| Group I metabotropic glutamate antagonist reduces acute neuronal degeneration and behavioral deficits after traumatic brain injury in rats. | Experimental neurology 20010501 |
| Dual role of glutamatergic neurotransmission on amyloid beta(1-42) aggregation and neurotoxicity in embryonic avian retina. | Neuroscience letters 20010323 |
| Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improvesoOutcome after brain trauma. | Experimental neurology 20010201 |
| Metabotropic glutamate receptors modulate GABA release from mouse hippocampal slices. | Neurochemical research 20010201 |
| The role of kainic acid/AMPA and metabotropic glutamate receptors in the regulation of opioid mRNA expression and the onset of pain-related behavior following excitotoxic spinal cord injury. | Neuroscience 20010101 |
| Activation of group II metabotropic glutamate receptors results in long-term potentiation following preconditioning stimulation in the dentate gyrus. | Neuroscience 20010101 |
| AIDA influences behavior in rats pretreated with baclofen. | Polish journal of pharmacology 20010101 |
| Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. | Journal of neurochemistry 20001201 |
| The role of metabotropic glutamate receptor (mGluR) ligands in parkinsonian muscle rigidity. | Amino acids 20000101 |
| Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist. | The Journal of pharmacology and experimental therapeutics 19970501 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.