200,000+ products from a single source!
sales@angenechem.com
16846-24-5 | Leucomycin V, 3-acetate 4B-(3-methylbutanoate)
CAS No: 16846-24-5 Catalog No: AG001Y2Q MDL No:MFCD00210320
Product Description
Catalog Number:
AG001Y2Q
Chemical Name:
Leucomycin V, 3-acetate 4B-(3-methylbutanoate)
CAS Number:
16846-24-5
Molecular Formula:
C42H69NO15
Molecular Weight:
827.9950
MDL Number:
MFCD00210320
IUPAC Name:
[(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-acetyloxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3-methylbutanoate
InChI:
InChI=1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1
InChI Key:
XJSFLOJWULLJQS-NGVXBBESSA-N
SMILES:
O=CC[C@H]1C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@H](OC(=O)C[C@H]([C@@H]([C@H]1O[C@@H]1O[C@H](C)[C@H]([C@@H]([C@H]1O)N(C)C)O[C@@H]1O[C@@H](C)[C@@H]([C@](C1)(C)O)OC(=O)CC(C)C)OC)OC(=O)C)C
EC Number:
240-871-6
UNII:
HV13HFS217
Properties
Complexity:
1390
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
16
Defined Bond Stereocenter Count:
2
Exact Mass:
827.467g/mol
Formal Charge:
0
Heavy Atom Count:
58
Hydrogen Bond Acceptor Count:
16
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
828.006g/mol
Monoisotopic Mass:
827.467g/mol
Rotatable Bond Count:
14
Topological Polar Surface Area:
206A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.9
Literature
| Title | Journal |
|---|---|
| Azithromycin inhibits mucus hypersecretion from airway epithelial cells. | Mediators of inflammation 20120101 |
| [The influence of ultrasonic radiation on the factors of antimicrobial resistance in the women of reproductive age presenting with mycoplasma infection of the urogenital tract]. | Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury 20120101 |
| [Detection and the antibiotic susceptibility analysis of mycoplasma and chlamydia in urogenital tract infections of 327 cases patients with tubal infertility]. | Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20110601 |
| [Effect of combined therapy using complex of natural cytokines and antimicrobial peptides in urogenital infections caused by Chlamydia and Mycoplasma]. | Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20110101 |
| [Antibiotic resistance as a public health problem: the case of genital mycoplasmoses]. | Igiene e sanita pubblica 20110101 |
| High-content screening for compounds that affect mtDNA-encoded protein levels in eukaryotic cells. | Journal of biomolecular screening 20100901 |
| Outcome of very preterm infants with Mycoplasma/Ureaplasma airway colonization treated with josamycine. | Acta paediatrica (Oslo, Norway : 1992) 20100401 |
| Structure elucidation, complete NMR assignment and PM5 theoretical studies of new hydroxy-aminoalkyl-alpha,beta-unsaturated derivatives of the macrolide antibiotic josamycin. | Magnetic resonance in chemistry : MRC 20100401 |
| Fragmentation pathways of new aza derivatives of 16-membered macrolide antibiotic--analog of Josamycin investigated by ESI and FAB mass spectrometric methods. | Journal of mass spectrometry : JMS 20090901 |
| Cis-acting resistance peptides reveal dual ribosome inhibitory action of the macrolide josamycin. | Biochimie 20090801 |
| [Streptococcal perianal dermatitis and guttate psoriasis]. | Annales de dermatologie et de venereologie 20090101 |
| Development of a liquid chromatography method for the analysis of josamycin. | Journal of pharmaceutical and biomedical analysis 20080929 |
| Two unusual glandular presentations of tick-borne tularemia. | Medecine et maladies infectieuses 20080301 |
| Molecular analysis of constitutive mutations in ermB and ermA selected in vitro from inducibly MLSB-resistant enterococci. | Archives of pharmacal research 20080301 |
| Differential activity profiles of translation inhibitors in whole-cell and cell-free approaches. | Letters in applied microbiology 20080201 |
| Macrolides attenuate mucus hypersecretion in rat airways through inactivation of NF-kappaB. | Respirology (Carlton, Vic.) 20080101 |
| Determination of josamycin in rat plasma by capillary electrophoresis coupled with post-column electrochemiluminescence detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071101 |
| Preparation of floating microspheres for fish farming. | International journal of pharmaceutics 20070816 |
| [Determination of five macrolide antibiotic residues in royal jelly samples by using high performance liquid chromatography tandem mass spectrometry]. | Se pu = Chinese journal of chromatography 20070501 |
| Sample preparation strategy for the simultaneous determination of macrolide antibiotics in animal feedingstuffs by liquid chromatography with electrochemical detection (HPLC-ECD). | Journal of pharmaceutical and biomedical analysis 20070411 |
| Effect of macrolide antibiotics on uptake of digoxin into rat liver. | Biopharmaceutics & drug disposition 20070401 |
| [Is it safe to use josamycin in the obstetrics practice in Russia?]. | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20070101 |
| [Digoxin-Josamycin: a dangerous drug interaction in children]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20060801 |
| Liquid chromatography-UV diode-array detection method for multi-residue determination of macrolide antibiotics in sheep's milk. | Journal of chromatography. A 20060728 |
| [Female urogenital mycoplasma infection and drug sensitivity status in Changsha]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060601 |
| [Identification of the components and products of hydrolysis in acetylleucomycin by LC-MS]. | Yao xue xue bao = Acta pharmaceutica Sinica 20060501 |
| The molecular mechanism of peptide-mediated erythromycin resistance. | The Journal of biological chemistry 20060310 |
| [Evaluation of efficacy and safety of josamycin (Vilprafen) in the treatment of patients with community-acquired pneumonia]. | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20060101 |
| [Simultaneous determination of josamycin, theophylline and paracetamol in pharmaceutical waste water by high performance liquid chromatography]. | Se pu = Chinese journal of chromatography 20050501 |
| Kinetics of macrolide action: the josamycin and erythromycin cases. | The Journal of biological chemistry 20041217 |
| Macrolide antibiotics induce apoptosis of human peripheral lymphocytes in vitro. | International journal of antimicrobial agents 20040901 |
| Antimicrobial susceptibility and macrolide resistance genes in Streptococcus pyogenes collected in Austria and Hungary. | International journal of antimicrobial agents 20040901 |
| Anodic polarographic determination of josamycin in formulations and spiked human urine. | Farmaco (Societa chimica italiana : 1989) 20040701 |
| [Effect of macrolides on matrix protein decomposing enzyme (MMP) production]. | The Japanese journal of antibiotics 20040601 |
| [The mechanism of apoptosis induction in lymphocytes by macrolide antibiotics and the related intra-cellular molecular structure]. | The Japanese journal of antibiotics 20040601 |
| Suppression of matrix metalloproteinase production from nasal fibroblasts by macrolide antibiotics in vitro. | The European respiratory journal 20040501 |
| Detection of mutant Mycoplasma hominis strains resistant to 16-membered macrolide antibiotic josamycin in clinical samples. | Bulletin of experimental biology and medicine 20040501 |
| Macrolides inhibit epithelial cell-mediated neutrophil survival by modulating granulocyte macrophage colony-stimulating factor release. | American journal of respiratory cell and molecular biology 20040401 |
| Application of liquid chromatography-ion trap mass spectrometry to the characterization of the 16-membered ring macrolide josamycin propionate. | Journal of mass spectrometry : JMS 20040401 |
| Modification of phagocytosis and cytokine production in peritoneal and splenic murine cells by erythromycin A, azithromycin and josamycin. | The Journal of antimicrobial chemotherapy 20040201 |
| [Efficacy of different schemes of anti-helicobacter therapy in duodenal ulcer]. | Terapevticheskii arkhiv 20040101 |
| Kinetic spectrophotometric determination of josamycin in formulations and spiked human plasma using 3-methylbenzothiazolin-2-one hydrazone/Fe+3 system. | Journal of AOAC International 20040101 |
| Skin delayed-type hypersensitivity to josamycin. | Allergy 20031201 |
| Suppressive activity of macrolide antibiotics on nitric oxide production from nasal polyp fibroblasts in vitro. | Acta oto-laryngologica 20031201 |
| In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells. | American journal of respiratory and critical care medicine 20030901 |
| Influence of roxithromycin on inflammatory cytokine production from nasal polyp fibroblasts in vitro. | Acta oto-laryngologica 20030601 |
| Synthesis of new 14-membered macrolide antibiotics via a novel ring contraction metathesis. | Organic letters 20030220 |
| Severe colchicine-macrolide interactions. | Prescrire international 20030201 |
| Clinical and laboratory characteristics of 144 patients with mediterranean spotted fever. | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20030201 |
| [Urogenital chlamydia infection: treatment with wilprafen]. | Urologiia (Moscow, Russia : 1999) 20030101 |
| [Experience in wilaprafen treatment of chlamydial prostatitis, complicated by infertility]. | Urologiia (Moscow, Russia : 1999) 20030101 |
| Kinetic spectrophotometric determination of the macrolide antibiotic josamycin in formulations. | Journal of AOAC International 20030101 |
| [Drug sensitivity of Ureaplasma urealyticum, persisting in patients with chronic inflammatory diseases of the urogenital tract]. | Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20030101 |
| Susceptibility of mixed infection of Ureaplasma Urealyticum and Mycoplasma Hominis to seven antimicrobial agents and comparison with that of Ureaplasma Urealyticum infection. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20030101 |
| [New achievements in the diagnosis and treatment of disseminated urogenital chlamydiosis]. | Vestnik Rossiiskoi akademii meditsinskikh nauk 20030101 |
| [Treatment of genital chlamydia infections with wilprafen (josamycin)]. | Akusherstvo i ginekologiia 20030101 |
| Voltammetric determination of josamycin (a macrolide antibiotic) in dosage forms and spiked human urine. | Journal of pharmaceutical and biomedical analysis 20021015 |
| Quantitative comparison of the cytocidal effect of seven macrolide antibiotics on human periodontal ligament fibroblasts. | Journal of periodontal research 20020801 |
| The effect of josamycine on the control of ileitis in weaned piglets under field conditions. | Journal of veterinary pharmacology and therapeutics 20020801 |
| A chronic toxicity study of josamycin in F344 rats. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020701 |
| In vitro and ex vivo effects of erythromycin A, azithromycin and josamycin on the splenic response to specific antigens and mitogens. | The Journal of antimicrobial chemotherapy 20020601 |
| [Comment on Borrelia burgdorferi Group infections]. | Orvosi hetilap 20020526 |
| Effect of clarithromycin on chronic respiratory infection caused by Pseudomonas aeruginosa with biofilm formation in an experimental murine model. | The Journal of antimicrobial chemotherapy 20020501 |
| Clarithromycin for the treatment of Mediterranean spotted fever. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020215 |
| Modulatory effect of macrolide antibiotics on the Th1- and Th2-type cytokine production. | International journal of antimicrobial agents 20020101 |
| Inhibitory effects of 14-membered ring macrolide antibiotics on bleomycin-induced acute lung injury. | Lung 20020101 |
| [Effect of clarithromycin on lipopolysaccharide-induced anorexia]. | The Japanese journal of antibiotics 20011201 |
| [Effect of macrolide antibiotics on mucus secretion from cultured epithelial cells of nasal mucosa]. | The Japanese journal of antibiotics 20011201 |
| Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients. | Immunopharmacology and immunotoxicology 20011101 |
| Gene expression profiles of human small airway epithelial cells treated with low doses of 14- and 16-membered macrolides. | Biochemical and biophysical research communications 20010914 |
| Enhancement of endogenous corticosterone levels by a macrolide antibiotic, roxithromycin in mice. | Life sciences 20010727 |
| [Treatment of acute group A beta-hemolytic streptococcal tonsillitis in children with a 5-day course of josamycin]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20010701 |
| In vitro activity of midecamycin diacetate, a 16-membered macrolide, against Streptococcus pyogenes isolated in France, 1995-1999. | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20010701 |
| [Effect of macrolide antibiotics on apoptosis induction]. | The Japanese journal of antibiotics 20010201 |
| [Effects and action mechanisms of macrolides on IgG- immune complex lung injury models]. | The Japanese journal of antibiotics 20010201 |
| [Experience in treating chronic periodontal diseases with vilprafene (josamycin)]. | Stomatologiia 20010101 |
| [Vilprafene (josamycin) therapy of chronic chlamydial prostatitis]. | Urologiia (Moscow, Russia : 1999) 20010101 |
| In vitro susceptibilities of rapidly growing mycobacteria to telithromycin (HMR 3647) and seven other antimicrobials. | Antimicrobial agents and chemotherapy 20000101 |
| In vitro stimulation of polymorphonuclear cell adhesion by ribomunyl and antibiotic + ribomunyl combinations: effects on CD18, CD35 and CD16 expression. | International journal of immunopharmacology 19930201 |
| Troleandomycin hepatotoxicity: a case report of overt jaundice and a placebo-controlled trial. | Therapie 19930101 |
| In vitro activity of antimicrobial agents against mycobacteria. | Drugs under experimental and clinical research 19880101 |
| Screening for new compounds with antiherpes activity. | Antiviral research 19841001 |
Related Products
© 2019 Angene International Limited. All rights Reserved.