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1684-40-8

1684-40-8 | 9-Acridinamine, 1,2,3,4-tetrahydro-, hydrochloride (1:1)

CAS No: 1684-40-8 Catalog No: AG001Y1M MDL No:MFCD00012657

Product Description

Catalog Number:
AG001Y1M
Chemical Name:
9-Acridinamine, 1,2,3,4-tetrahydro-, hydrochloride (1:1)
CAS Number:
1684-40-8
Molecular Formula:
C13H15ClN2
Molecular Weight:
234.7246
MDL Number:
MFCD00012657
IUPAC Name:
1,2,3,4-tetrahydroacridin-9-amine;hydrochloride
InChI:
InChI=1S/C13H14N2.ClH/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H
InChI Key:
ZUFVXZVXEJHHBN-UHFFFAOYSA-N
SMILES:
Nc1c2CCCCc2nc2c1cccc2.Cl
EC Number:
216-867-5
UNII:
4966RNG0BU

Properties

Complexity:
229  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
234.092g/mol
Formal Charge:
0
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
234.727g/mol
Monoisotopic Mass:
234.092g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
38.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Literature

Title Journal
Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca²⁺ overload. Bioorganic & medicinal chemistry 20121101
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease. Bioorganic & medicinal chemistry letters 20121015
Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects. The Journal of biological chemistry 20121005
O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation. Bioorganic & medicinal chemistry 20121001
Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease. European journal of medicinal chemistry 20120901
Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins. Brain research 20120827
Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo. Journal of medicinal chemistry 20120614
Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: involvement in hippocampal neuronal loss in Alzheimer's disease. Neurobiology of disease 20120601
Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and hepatoprotective properties in tacrine-treated HepG2 cells. Journal of agricultural and food chemistry 20120530
Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors. Journal of medicinal chemistry 20120510
Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids. Bioorganic & medicinal chemistry 20120501
Solid-state characterization of tacrine hydrochloride. Journal of pharmaceutical and biomedical analysis 20120407
Effect of bis(7)-tacrine on cognition in rats with chronic cerebral ischemia. Neuroscience letters 20120323
Affinity binding-guided fluorescent nanobiosensor for acetylcholinesterase inhibitors via distance modulation between the fluorophore and metallic nanoparticle. Analytical chemistry 20120320
Pharmacokinetics and brain dispositions of tacrine and its major bioactive monohydroxylated metabolites in rats. Journal of pharmaceutical and biomedical analysis 20120305
Tacrine and its analogues impair mitochondrial function and bioenergetics: a lipidomic analysis in rat brain. Journal of neurochemistry 20120301
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties. Journal of medicinal chemistry 20120209
Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. Neuropharmacology 20120201
Tanshinone I increases CYP1A2 protein expression and enzyme activity in primary rat hepatocytes. Phytomedicine : international journal of phytotherapy and phytopharmacology 20120115
Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents. Neuro-degenerative diseases 20120101
Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo. PloS one 20120101
2,3-dihydro-1H-cyclopenta[b]quinoline derivatives as acetylcholinesterase inhibitors-synthesis, radiolabeling and biodistribution. International journal of molecular sciences 20120101
A single-center, randomized, open-label, dose-escalation study to evaluate the pharmacokinetics of tacrine analogue octahydrogenacridine succinate tablets in healthy Chinese subjects. Biological & pharmaceutical bulletin 20120101
An electrochemical platform for acetylcholinesterase activity assay and inhibitors screening based on Michael addition reaction between thiocholine and catechol-terminated SAMs. The Analyst 20111207
Cognitive dysfunctions induced by a cholinergic blockade and Aβ 25-35 peptide are attenuated by salvianolic acid B. Neuropharmacology 20111201
Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway. Neurochemistry international 20111201
Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues. European journal of medicinal chemistry 20111201
Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease. Current topics in medicinal chemistry 20111101
Effective pharmacological management of Alzheimer's disease. The American journal of managed care 20111101
ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor. Behavioural brain research 20111010
Tacrine and bis(7)-tacrine attenuate cycloheximide-induced amnesia in mice, with attention to acute toxicity. Basic & clinical pharmacology & toxicology 20111001
Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice. Fitoterapia 20111001
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors. European journal of medicinal chemistry 20111001
Reversible human serum albumin binding of lipocrine: a circular dichroism study. Chirality 20111001
Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice. Planta medica 20110901
Reversible inhibition of esterase activity after separation and immobilization. Applied biochemistry and biotechnology 20110901
Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors. European journal of medicinal chemistry 20110801
Synthesis and biological activity of derivatives of tetrahydroacridine as acetylcholinesterase inhibitors. Bioorganic chemistry 20110801
New drugs for Alzheimer's disease in Japan. Psychiatry and clinical neurosciences 20110801
Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity. European journal of pharmacology 20110625
HFE polymorphisms affect cellular glutamate regulation. Neurobiology of aging 20110601
Tacrine treatment at high dose suppresses the recognition memory in juvenile and adult mice with attention to hepatotoxicity. Basic & clinical pharmacology & toxicology 20110601
Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents. European journal of medicinal chemistry 20110601
Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines. Bioorganic & medicinal chemistry letters 20110415
Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and Aβ-aggregation inhibitors. Bioorganic & medicinal chemistry 20110401
Inhibition mechanism of rat α₃β₄ nicotinic acetylcholine receptor by the Alzheimer therapeutic tacrine. Biochemistry 20110322
Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. Drug metabolism and disposition: the biological fate of chemicals 20110301
Clicked tacrine conjugates as acetylcholinesterase and β-amyloid directed compounds. Organic & biomolecular chemistry 20110221
Acetylcholinesterase inhibitors partially generalize to nicotine discriminative stimulus effect in rats. Behavioural pharmacology 20110201
Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation. Bioorganic & medicinal chemistry 20110115
Potency determinations of acetylcholinesterase inhibitors using Ellman's reaction-based assay in screening: Effect of assay variants. Analytical biochemistry 20110101
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles. Bioorganic & medicinal chemistry 20110101
[Comparative sensitivity of liver monoamine oxidases of frog and whitefish to some tricyclic compounds]. Zhurnal evoliutsionnoi biokhimii i fiziologii 20110101
In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain. Neuro endocrinology letters 20110101
Diabetes-induced central cholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription, kangen-karyu: elucidation in type 2 diabetes db/db mice. Journal of pharmacological sciences 20110101
Sensitizing effect of tacrine on M-cholinergic receptors in gastric smooth muscle of rats. Folia medica 20110101
Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state. Journal of the American Chemical Society 20101229
Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment. Molecules (Basel, Switzerland) 20101202
Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands. Analytical biochemistry 20101201
Action potential bursts in central snail neurons elicited by procaine: roles of ionic currents. The Chinese journal of physiology 20101031
Design, synthesis, and molecular-modeling study of aminothienopyridine analogues of tacrine for Alzheimer's disease. Archiv der Pharmazie 20101001
Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia. Journal of natural products 20100924
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates. Chemico-biological interactions 20100906
Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities. ChemMedChem 20100802
Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties. Journal of medicinal chemistry 20100708
Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin. The Journal of biological chemistry 20100625
Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats. Neurobiology of aging 20100601
A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's disease. Neurotoxicity research 20100501
Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors. Journal of medicinal chemistry 20100311
Differential effects of systemic and intraseptal administration of the acetylcholinesterase inhibitor tacrine on the recovery of spatial behavior in an animal model of diencephalic amnesia. European journal of pharmacology 20100310
A novel animal model to evaluate the ability of a drug delivery system to promote the passage through the BBB. Neuroscience letters 20100118
Tribuli fructus constituents protect against tacrine-induced cytotoxicity in HepG2 cells. Archives of pharmacal research 20100101
Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage. BMC neuroscience 20100101
Tacrine derivatives and Alzheimer's disease. Current medicinal chemistry 20100101
Tacrine-NO donor and tacrine-ferulic acid hybrid molecules as new anti-Alzheimer agents: hepatotoxicity and influence on the cytochrome P450 system in comparison to tacrine. Arzneimittel-Forschung 20100101
Investigation into the in vivo effects of five novel tacrine/ferulic acid and beta-carboline derivatives on scopolamine-induced cognitive impairment in rats using radial maze paradigm. Arzneimittel-Forschung 20100101
Rapid determination of tacrine and other drug metabolites in microsomal incubate by newly developed targeting algorithm on UHPLC/TOFMS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091215
Object location memory in mice: pharmacological validation and further evidence of hippocampal CA1 participation. Behavioural brain research 20091201
Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently. European journal of pharmacology 20091125
Differential effects of adenosine antagonists in two models of parkinsonian tremor. Pharmacology, biochemistry, and behavior 20091101
Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2. Toxicology and applied pharmacology 20091101
Long-lasting decreases in cocaine-reinforced behavior following treatment with the cholinesterase inhibitor tacrine in rats selectively bred for drug self-administration. Pharmacology, biochemistry, and behavior 20091101
Ximelagatran increases membrane fluidity and changes membrane lipid composition in primary human hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA 20091001
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology 20091001
Chromone glycosides and hepatoprotective constituents of Hypericum erectum. Archives of pharmacal research 20091001
The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain. Biochimie 20090901
The inhibitory avoidance test optimized for discovery of cognitive enhancers. Behavior research methods 20090801
Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons. Neuropharmacology 20090701
Identification of FDA-approved drugs and bioactives that protect hair cells in the zebrafish (Danio rerio) lateral line and mouse (Mus musculus) utricle. Journal of the Association for Research in Otolaryngology : JARO 20090601
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. Journal of medicinal chemistry 20090514
Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties. ChemMedChem 20090501
Kinetics of inhibition of acetylcholinesterase in the presence of acetonitrile. The FEBS journal 20090401
Redox thiol status plays a central role in the mobilization and metabolism of nitric oxide in human red blood cells. Cell biology international 20090301
Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation. Biological & pharmaceutical bulletin 20090301
Modulation of erythrocyte acetylcholinesterase activity and its association with G protein-band 3 interactions. The Journal of membrane biology 20090301
[Progress in the research on multi-target-directed drugs against Alzheimer's disease]. Yao xue xue bao = Acta pharmaceutica Sinica 20090301
Assessment of symptomatic and neuroprotective efficacy of Mucuna pruriens seed extract in rodent model of Parkinson's disease. Neurotoxicity research 20090201
Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors. Biochemistry 20090127
Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect. Parkinsonism & related disorders 20090101
Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20090101
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond. Current pharmaceutical design 20090101
Inhibitory potency of choline esterase inhibitors on acetylcholine release and choline esterase activity in fresh specimens of human and rat neocortex. Journal of Alzheimer's disease : JAD 20090101
Comparison studies of tacrine and bis7-tacrine on the suppression of scopolamine-induced behavioral changes and inhibition of acetylcholinesterase in mice. Pharmacology 20090101
NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity. Journal of medicinal chemistry 20081225
[Protection effects of acetylcholinesterase inhibitors on apoptosis]. Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20081201
A universal method for fishing target proteins from mixtures of biomolecules using isothermal titration calorimetry. Protein science : a publication of the Protein Society 20081001
New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrine. Neuro endocrinology letters 20081001
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point. Journal of pharmaceutical and biomedical analysis 20080910
An algorithm for thorough background subtraction from high-resolution LC/MS data: application for detection of glutathione-trapped reactive metabolites. Journal of mass spectrometry : JMS 20080901
Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. American journal of physiology. Gastrointestinal and liver physiology 20080901
Weak intermolecular interactions in 11-chloro-2,3,4,5-tetrahydro-1H-cyclohepta[b]quinoline. Acta crystallographica. Section C, Crystal structure communications 20080901
Extracts and constituents of Leontopodium alpinum enhance cholinergic transmission: brain ACh increasing and memory improving properties. Biochemical pharmacology 20080715
Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia. Neuroscience letters 20080711
MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats. Journal of neural transmission (Vienna, Austria : 1996) 20080701
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Journal of medicinal chemistry 20080626
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors. Journal of medicinal chemistry 20080612
Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies. Neuropharmacology 20080601
Antipsychotic-like behavioral effects and cognitive enhancement by a potent and selective muscarinic M-sub-1 receptor agonist, AC-260584. Behavioral neuroscience 20080601
Effects of tamoxifen on L-glutamate transporters of astrocytes. Journal of pharmacological sciences 20080601
The cholinergic system in cyclophosphamide-induced Chagas dilated myocardiopathy in Trypanosoma-cruzi-infected rats: an electrocardiographic study. Investigacion clinica 20080601
Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors. Biochemical and biophysical research communications 20080516
Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates. Bioorganic & medicinal chemistry letters 20080501
In vitro hepatoprotective compounds from Suaeda glauca. Archives of pharmacal research 20080501
Diagnosis and treatment of dementia with Lewy bodies. JAAPA : official journal of the American Academy of Physician Assistants 20080501
AAFP and ACP release guideline on dementia treatment. American family physician 20080415
Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC 20080401
Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice. European journal of pharmacology 20080310
Summaries for patients. Drug treatment for patients with dementia: American College of Physicians and American Academy of Family Physicians recommendations. Annals of internal medicine 20080304
Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians. Annals of internal medicine 20080304
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Annals of internal medicine 20080304
Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity. Biochemical and biophysical research communications 20080215
Effect of tacrine, amiridine, akatinol memantine, and triazolam on phosphorylation, structure, and assembly of microtubules from brain microtubular proteins in Alzheimer diseases. Bulletin of experimental biology and medicine 20080201
The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine. Journal of pharmaceutical and biomedical analysis 20080107
Effects of zonisamide on experimental tremors in rats. Parkinsonism & related disorders 20080101
Dose-related effects of the acetylcholinesterase inhibitor tacrine on cocaine and food self-administration in rats. Psychopharmacology 20080101
Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions. PloS one 20080101
Hepatoprotective effect of Cirsium arisanense Kitamura in tacrine-treated hepatoma Hep 3B cells and C57BL mice. The American journal of Chinese medicine 20080101
Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds. Journal of pharmacological and toxicological methods 20080101
Modulation of hemorheological parameters by the erythrocyte redox thiol status. Clinical hemorheology and microcirculation 20080101
Non-neuronal cholinergic system and signal transduction pathways mediated by band 3 in red blood cells. Clinical hemorheology and microcirculation 20080101
Protective effect of reversible cholinesterase inhibitors (tacrine, pyridostigmine) and eqbuche against VX poisoning and brain acetylcholinesterase inhibition in rats. Acta medica (Hradec Kralove) 20080101
A new acetylcholinesterase inhibitor with anti-PAF activity modulates oxidative stress and pro-inflammatory mediators release in stimulated RAW 264.7 macrophage cells. Comparison with tacrine. International immunopharmacology 20071215
Tacrine-induced liver damage: an analysis of 19 candidate genes. Pharmacogenetics and genomics 20071201
First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor. Journal of medicinal chemistry 20071115
Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. Pharmacogenetics and genomics 20071101
Thermodynamic analysis of binding between drugs and glycosaminoglycans by isothermal titration calorimetry and fluorescence spectroscopy. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071001
Evaluation of centrally acting cholinesterase inhibitor exposures in adults. The Annals of pharmacotherapy 20071001
Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents. Biochemical and biophysical research communications 20070921
Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood. Journal of pharmaceutical and biomedical analysis 20070903
Alzheimer's disease: will advances made in the past turn the tide? The Annals of pharmacotherapy 20070901
Nose-to-brain delivery of tacrine. The Journal of pharmacy and pharmacology 20070901
The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice. Journal of pharmacological sciences 20070901
East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A. Current Alzheimer research 20070901
Treating autism pharmacologically: also tacrine might improve symptomatology in some cases. Journal of child neurology 20070801
WITHDRAWN: Tacrine for Alzheimer's disease. The Cochrane database of systematic reviews 20070718
Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats. European journal of pharmacology 20070702
Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons. Journal of proteome research 20070701
Effect of histamine on muscimol-induced working memory deficits in radial maze performance. Journal of pharmacological sciences 20070701
Cytoprotective constituent of Hoveniae Lignum on both Hep G2 cells and rat primary hepatocytes. Archives of pharmacal research 20070601
Cholinesterase inhibitors reduce cortical Abeta in dementia with Lewy bodies. Neurology 20070515
Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase. Molecular pharmacology 20070501
Effect of anti-dementia drugs on LPS induced neuroinflammation in mice. Life sciences 20070501
Mutational disruption of a conserved disulfide bond in muscarinic acetylcholine receptors attenuates positive homotropic cooperativity between multiple allosteric sites and has subtype-dependent effects on the affinities of muscarinic allosteric ligands. Molecular pharmacology 20070301
The application of evidence-based principles of care in older persons (issue 5): Alzheimer's disease. Journal of the American Medical Directors Association 20070301
Alkylene tether-length dependent gamma-aminobutyric acid type A receptor competitive antagonism by tacrine dimers. Neuropharmacology 20070201
Screening of acetylcholinesterase inhibitors in natural extracts by CE with electrophoretically mediated microanalysis technique. Electrophoresis 20070201
Re-evaluation of tacrine hepatotoxicity using gel entrapped hepatocytes. Toxicology letters 20070130
Effects of velnacrine maleate in the leukocyte-endothelial cell interactions in rat cremaster microcirculatory network. Clinical hemorheology and microcirculation 20070101
Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment. Current medicinal chemistry 20070101
Long-term tetrahydroaminoacridine treatment and quantitative EEG in Alzheimer's disease. Journal of neural transmission. Supplementum 20070101
Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease. Journal of medicinal chemistry 20061228
New multipotent tetracyclic tacrines with neuroprotective activity. Bioorganic & medicinal chemistry 20061215
Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase. Journal of medicinal chemistry 20061214
Fluorescent method for evaluation of cholinesterase inhibitors. Bulletin of experimental biology and medicine 20061201
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole. Journal of medicinal chemistry 20061116
Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity. European journal of pharmacology 20061107
Calcium-independent tacrine-induced relaxation of rat gastric corpus smooth muscles. Canadian journal of physiology and pharmacology 20061101
Rapid method for evaluation of cholinesterase inhibitors. Bulletin of experimental biology and medicine 20061101
Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease. Journal of the neurological sciences 20061025
Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease. Journal of molecular graphics & modelling 20061001
Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase. Journal of medicinal chemistry 20060907
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge. Journal of medicinal chemistry 20060907
Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells. Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairment. Toxicology in vitro : an international journal published in association with BIBRA 20060901
Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels. Journal of neurochemistry 20060901
Evaluation of acute tacrine treatment on passive-avoidance response, open-field behavior, and toxicity in 17- and 30-day-old mice. Pharmacology, biochemistry, and behavior 20060901
Inhibition of two different cholinesterases by tacrine. Chemico-biological interactions 20060825
[Mechanisms of neuroprotective effects of therapeutic acetylcholinesterase inhibitors used in treatment of Alzheimer's disease]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060801
Cover note article on the muscle relaxants suxamethonium and THA. Anaesthesia and intensive care 20060801
Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20060701
Choline pivaloyl ester strengthened the benefit effects of Tacrine and Galantamine on electroencephalographic and cognitive performances in nucleus basalis magnocellularis-lesioned and aged rats. Pharmacology, biochemistry, and behavior 20060701
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites. Journal of medicinal chemistry 20060601
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine. Neuroreport 20060403
Olfactory nerve-evoked, metabotropic glutamate receptor-mediated synaptic responses in rat olfactory bulb mitral cells. Journal of neurophysiology 20060401
New tacrine-hydrazinonicotinamide hybrids as acetylcholinesterase inhibitors of potential interest for the early diagnostics of Alzheimer's disease. Die Pharmazie 20060401
Muscle relaxants--suxamethonium and THA. Anaesthesia and intensive care 20060201
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties. Journal of medicinal chemistry 20060126
Memory-dependent novelty-related location preferences: sex-related attenuation of forgetting by D-glucose and tacrine. Behavioural brain research 20060106
Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine. Journal of peptide science : an official publication of the European Peptide Society 20060101
Chronic exposure of rats to cognition enhancing drugs produces a neuroplastic response identical to that obtained by complex environment rearing. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060101
CSF biomarkers for Alzheimer's Disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival. Dementia and geriatric cognitive disorders 20060101
Long-term depression of neuron to glial signalling in rat cerebellar cortex. The European journal of neuroscience 20060101
Automated method, based on micro-sequential injection, for the study of enzyme kinetics and inhibition. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060101
Current and emerging pharmacological treatment options for dementia. Behavioural neurology 20060101
Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease. Alzheimer disease and associated disorders 20060101
Pharmacological characterization of orally active cholinesterase inhibitory activity of Prunus persica L. Batsch in rats. Journal of molecular neuroscience : MN 20060101
Alzheimer disease and its management: a review. American journal of therapeutics 20060101
Effect of tacrine on cytosolic Ca2+ level and calmodulin in gastric muscle tissues of rat. Folia medica 20060101
Induced fit in mouse acetylcholinesterase upon binding a femtomolar inhibitor: a molecular dynamics study. Journal of medicinal chemistry 20051229
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE. Bioorganic & medicinal chemistry 20051215
Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors. Molecular pharmacology 20051201
Allosteric binding sites on muscarinic acetylcholine receptors. Molecular pharmacology 20051201
Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine-induced cytotoxicity in Hep G2 cells. Archives of pharmacal research 20051201
Intestinal single-pass in situ perfusion technique in rat: the influence of L-carnitine on absorption of 7-methoxytacrine. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201
Dementia. Clinical evidence 20051201
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease. Journal of medicinal chemistry 20051117
Random chemistry as a new tool for the generation of small compound libraries: development of a new acetylcholinesterase inhibitor. Journal of medicinal chemistry 20051117
Phenolic constituents of galla Rhois with hepatoprotective effects on tacrine- and nitrofurantoin-induced cytotoxicity in Hep G2 cells. Biological & pharmaceutical bulletin 20051101
Structural basis for inhibition of histamine N-methyltransferase by diverse drugs. Journal of molecular biology 20051021
Modulation of spontaneous alternation performance of mice treated with thioperamide and tacrine in a cross maze task. Fundamental & clinical pharmacology 20051001
Evidence for the involvement of central serotonergic mechanisms in cholinergic tremor induced by tacrine in Balb/c mice. Behavioural brain research 20050908
Consumption of charcoal-broiled meat as an experimental tool for discerning CYP1A2-mediated drug metabolism in vivo. Basic & clinical pharmacology & toxicology 20050901
SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist, alleviates disturbances of novelty discrimination in a social context in rats, a putative model of selective attention deficit. Psychopharmacology 20050801
Modification of motor cortical excitability by an acetylcholinesterase inhibitor. Experimental brain research 20050701
In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors. Journal of the American Chemical Society 20050511
Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors. The Journal of biological chemistry 20050506
Quetiapine (Seroquel) shows a pattern of behavioral effects similar to the atypical antipsychotics clozapine and olanzapine: studies with tremulous jaw movements in rats. Psychopharmacology 20050501
Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production. Annals of neurology 20050501
Role of molecular isoforms of acetylcholinesterase in learning and memory functions. Pharmacology, biochemistry, and behavior 20050501
Actions of tacrine and galanthamine on histamine-N-methyltransferase. Methods and findings in experimental and clinical pharmacology 20050401
Donepezil, tacrine and alpha-phenyl-n-tert-butyl nitrone (PBN) inhibit choline transport by conditionally immortalized rat brain capillary endothelial cell lines (TR-BBB). Archives of pharmacal research 20050401
Saturable distribution of tacrine into the striatal extracellular fluid of the rat: evidence of involvement of multiple organic cation transporters in the transport. Drug metabolism and disposition: the biological fate of chemicals 20050301
Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine. European journal of medicinal chemistry 20050301
Pharmacologic treatment options in Alzheimer's disease: optimizing disease management. Journal of the American Academy of Nurse Practitioners 20050301
Is donepezil therapy associated with reduced mortality in nursing home residents with dementia? The American journal of geriatric pharmacotherapy 20050301
Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism. European journal of pharmacology 20050221
Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243. Behavioural brain research 20050130
Rational approach to discover multipotent anti-Alzheimer drugs. Journal of medicinal chemistry 20050127
The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane. British journal of pharmacology 20050101
Synthesis and biological evaluation of tacrine-thiadiazolidinone hybrids as dual acetylcholinesterase inhibitors. Archiv der Pharmazie 20050101
[Treatment of dementia]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20050101
[Mitochondria as the target for neuroprotectors]. Vestnik Rossiiskoi akademii meditsinskikh nauk 20050101
Non-anticholinesterase, non-cholinergic effect of tacrine on gastrointestinal smooth muscle tissues of rat. Folia medica 20050101
In vitro inactivation of rat brain acetylcholinesterase by DSP-4 and its derivatives OS-21 and OS-23 and protective activity of tacrine (9-amino-1,2,3,4-tetrahydroacridine). Acta medica (Hradec Kralove) 20050101
(+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration. Journal of Alzheimer's disease : JAD 20041201
Dementia. Clinical evidence 20041201
Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens. European journal of pharmacology 20041025
Within-subject memory decline in middle-aged rats: effects of intraseptal tacrine. Neurobiology of aging 20041001
A prospective randomized double masked controlled clinical trial to determine the efficacy of multiple drop centbucridine as an ocular surface anaesthetic. Indian journal of physiology and pharmacology 20041001
A water extract of Curcuma longa L. (Zingiberaceae) rescues PC12 cell death caused by pyrogallol or hypoxia/reoxygenation and attenuates hydrogen peroxide induced injury in PC12 cells. Life sciences 20040924
Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry letters 20040920
ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a novel acetylcholinesterase inhibitor with 'calcium promotor' and neuroprotective properties. The Journal of pharmacology and experimental therapeutics 20040901
Blockade of adenosine A2A receptors antagonizes parkinsonian tremor in the rat tacrine model by an action on specific striatal regions. Experimental neurology 20040901
Tetrahydroacridine inhibits voltage-dependent Na(+) current in guinea-pig ventricular myocytes. Acta pharmacologica Sinica 20040901
An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa. Archives of pharmacal research 20040901
Alaternin and emodin with hydroxyl radical inhibitory and/or scavenging activities and hepatoprotective activity on tacrine-induced cytotoxicity in HepG2 cells. Archives of pharmacal research 20040901
An investigation of the effect of tacrine and physostigmine on spatial working memory deficits in the olfactory bulbectomised rat. Behavioural brain research 20040831
Inhibition of murine cytochrome P4501A by tacrine: in vitro studies. Drug metabolism and disposition: the biological fate of chemicals 20040801
A latent normal distribution model for analysing ordinal responses with applications in meta-analysis. Statistics in medicine 20040730
Nanosecond dynamics of acetylcholinesterase near the active center gorge. The Journal of biological chemistry 20040618
Inhibition by bis(7)-tacrine of 5-HT-activated current in rat TG neurons. Neuroreport 20040607
Dementia. Clinical evidence 20040601
Cholesterol and APOE genotype interact to influence Alzheimer disease progression. Neurology 20040525
Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients. Journal of neurochemistry 20040301
Influence of tacrine on dopamine-induced reactions of the gastric smooth muscle of rats. Methods and findings in experimental and clinical pharmacology 20040301
Choline pivaloyl esters improve in rats cognitive and memory performances impaired by scopolamine treatment or lesions of the nucleus basalis of Meynert. Neuroscience letters 20040219
Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease. European journal of pharmacology 20040213
Simultaneous analysis of esterase and transferase activities in cytosol proteins from the bovine retina by using microscale non-denaturing two-dimensional electrophoresis. Biochimica et biophysica acta 20040114
Differences between clinical trials and postmarketing use. British journal of clinical pharmacology 20040101
Acetylcholinesterase inhibition in Alzheimer's Disease. Current pharmaceutical design 20040101
Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel. Archives of pharmacal research 20040101
Tetrahydroacridin-9-ones, 9-chlorotetrahydroacridines, 9-amino-tetrahydroacridines and 9-(pyrazol-1-yl)-tetrahydroacridines derived from chiral cyclanones. European journal of medicinal chemistry 20040101
[Drugs for the treatment of Alzheimer's disease]. Nihon rinsho. Japanese journal of clinical medicine 20040101
Velnacrine for Alzheimer's disease. The Cochrane database of systematic reviews 20040101
Use of cognitive enhancement medication in persons with Alzheimer disease who have a family caregiver: results from the Resources for Enhancing Alzheimer's Caregiver Health (REACH) project. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20040101
[Study of the cholinesterase active site using a fluorescent probe]. Izvestiia Akademii nauk. Seriia biologicheskaia 20040101
Comparison of desorption/ionization on silicon (DIOS) time-of-flight and liquid chromatography/tandem mass spectrometry for assaying enzyme-inhibition reactions. Rapid communications in mass spectrometry : RCM 20040101
The acetylcholinesterase inhibitors for treatment of cognitive and behavioral symptoms in dementia with Lewy bodies. The Journal of neuropsychiatry and clinical neurosciences 20040101
Spectrofluorimetric determination of velnacrine in human serum and urine. Farmaco (Societa chimica italiana : 1989) 20031201
Anticholinesterases in Alzheimer's disease: a modest effect on moderately severe disease. Prescrire international 20031201
[Synthesis of prodrugs of tacrine hydrochloride and evaluation of the stability and biodistribution in mice]. Yao xue xue bao = Acta pharmaceutica Sinica 20031201
Inhibitors tethered near the acetylcholinesterase active site serve as molecular rulers of the peripheral and acylation sites. The Journal of biological chemistry 20031003
Recent developments in the synthesis of acetylcholinesterase inhibitors. Mini reviews in medicinal chemistry 20030901
Tacrine inhibits topoisomerases and DNA synthesis to cause mitochondrial DNA depletion and apoptosis in mouse liver. Hepatology (Baltimore, Md.) 20030901
Benzodiazepine utilization patterns in Alzheimer's disease patients. Pharmacoepidemiology and drug safety 20030901
Reduction in distractibility with AF102B and THA in the macaque. Pharmacology, biochemistry, and behavior 20030901
Photoreversible inhibition of cholinesterases: catalytic serine-labeled caged butyrylcholinesterase. Chembiochem : a European journal of chemical biology 20030804
Flumazenil and tacrine increase the effectiveness of ondansetron on scopolamine-induced impairment of spatial learning in rats. Psychopharmacology 20030801
Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus. Journal of ethnopharmacology 20030801
Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors. Molecular pharmacology 20030701
Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. The Journal of pharmacology and experimental therapeutics 20030601
The clinical use of P300 event related potentials for the evaluation of cholinesterase inhibitors treatment in demented patients. Journal of neural transmission (Vienna, Austria : 1996) 20030601
Dementia. Clinical evidence 20030601
[Current therapy of patients with dementia]. MMW Fortschritte der Medizin 20030526
Manganese-based complexes of radical scavengers as neuroprotective agents. Bioorganic & medicinal chemistry 20030515
Pharmacology of delta2 glutamate receptors: effects of pentamidine and protons. The Journal of pharmacology and experimental therapeutics 20030501
Hepatoprotective phenolic constituents of Rhodiola sachalinensis on tacrine-induced cytotoxicity in Hep G2 cells. Phytotherapy research : PTR 20030501
Mitochondria as a target for neurotoxins and neuroprotective agents. Annals of the New York Academy of Sciences 20030501
Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition. Chemistry & biology 20030401
Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy. International clinical psychopharmacology 20030301
Acute effects of huperzine A and tacrine on rat liver. Acta pharmacologica Sinica 20030301
Cerebral glucose metabolism, cerebrospinal fluid-beta-amyloid1-42 (CSF-Abeta42), tau and apolipoprotein E genotype in long-term rivastigmine and tacrine treated Alzheimer disease (AD) patients. Neuroscience letters 20030227
Tacrine-scopolamine interactions on state-dependent retrieval. Psychopharmacology 20030201
Hormone replacement therapy in postmenopausal women with Alzheimer's disease: a randomized, prospective study. Fertility and sterility 20030201
Alzheimer's disease: emerging noncholinergic treatments. Geriatrics 20030201
Local injections of the 5-hydroxytryptamine antagonist mianserin into substantia nigra pars reticulata block tremulous jaw movements in rats: studies with a putative model of Parkinsonian tremor. Psychopharmacology 20030101
Centbucridine, a newer topical anaesthetic compared with lignocaine: a randomized double masked single drop instillation clinical trial. Indian journal of physiology and pharmacology 20030101
Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and Alzheimer's disease brain. Acta biologica Hungarica 20030101
Involvement of reduced acetylcholine release in Delta9-tetrahydrocannabinol-induced impairment of spatial memory in the 8-arm radial maze. Life sciences 20021220
Risk from lithium with acetylcholinesterase inhibitor. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20021201
Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine. European journal of pharmacology 20021129
[Anti-dementia drugs for Alzheimer disease in present and future]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101
Tacrine attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells. Brain research. Molecular brain research 20021030
In vivo and in vitro effects of aluminum on the activity of mouse brain acetylcholinesterase. Brain research bulletin 20021015
Effect of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone fumarate, a novel acetylcholinesterase inhibitor, on spatial cognitive impairment induced by chronic cerebral hypoperfusion in rats. Neuroscience letters 20021004
Dissolution and partitioning behavior of hydrophobic ion-paired compounds. Pharmaceutical research 20021001
[Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis]. Yao xue xue bao = Acta pharmaceutica Sinica 20020901
Clinical use of cholinomimetic agents: a review. The Journal of head trauma rehabilitation 20020801
Binding and release of drugs into and from thermosensitive poly(N-vinyl caprolactam) nanoparticles. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020701
Medical treatment of Alzheimer's disease: past, present, and future. Medicine and health, Rhode Island 20020701
Nicotine and sensory memory in Alzheimer's disease: an event-related potential study. Brain and cognition 20020701
Electroencephalographic activation by tacrine, deprenyl, and quipazine: cholinergic vs. non-cholinergic contributions. European journal of pharmacology 20020628
Novel tacrine derivatives that block neuronal calcium channels. Bioorganic & medicinal chemistry 20020601
Acute and chronic acetylcholinesterase inhibition regulates in vivo the localization and abundance of muscarinic receptors m2 and m4 at the cell surface and in the cytoplasm of striatal neurons. Molecular and cellular neurosciences 20020601
Acute nicotine effects on auditory sensory memory in tacrine-treated and nontreated patients with Alzheimer's disease: an event-related potential study. Pharmacology, biochemistry, and behavior 20020501
Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells. Planta medica 20020501
Determination of tacrine metabolites in microsomal incubate by high performance liquid chromatography-nuclear magnetic resonance/mass spectrometry with a column trapping system. Journal of pharmaceutical and biomedical analysis 20020401
Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents. The Journal of pharmacology and experimental therapeutics 20020401
Reversal of scopolamine-induced spatial memory deficits in rats by TAK-147. Acta pharmacologica Sinica 20020401
3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates. Biochemistry 20020305
Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice. Planta medica 20020301
Chronic treatments with tacrine and (-)-nicotine induce different changes of nicotinic and muscarinic acetylcholine receptors in the brain of aged rat. Journal of neural transmission (Vienna, Austria : 1996) 20020301
Abnormal expression of neuronal nitric oxide synthase triggers limbic seizures and hippocampal damage in rat. Biochemical and biophysical research communications 20020222
Electroencephalographic activation by fluoxetine in rats: role of 5-HT(1A) receptors and enhancement of concurrent acetylcholinesterase inhibitor treatment. Neuropharmacology 20020201
Effects of amphetamine on the plus-maze discriminative avoidance task in mice. Psychopharmacology 20020201
Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain. Japanese journal of pharmacology 20020201
[Protective effects of tacrine and donepezil against staurosporine-induced apoptotic death]. Yao xue xue bao = Acta pharmaceutica Sinica 20020201
Safety and efficacy of idebenone versus tacrine in patients with Alzheimer's disease: results of a randomized, double-blind, parallel-group multicenter study. Pharmacopsychiatry 20020101
Effects of acute nicotine administration on cognitive event-related potentials in tacrine-treated and non-treated patients with Alzheimer's disease. Neuropsychobiology 20020101
Understanding and managing behavioural symptoms in Alzheimer's disease and related dementias: focus on rivastigmine. Current medical research and opinion 20020101
Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors. Clinical pharmacokinetics 20020101
Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors. Journal of medicinal chemistry 20011220
Steroid hormones mediate sex difference in brain levels of tacrine and its hypothermic effect in the rat. Neuropharmacology 20011201
Galantamine: new preparation. The fourth cholinesterase inhibitor for Alzheimer's disease. Prescrire international 20011201
[Perspectives for drug treatment in Alzheimer's disease]. Annales de medecine interne 20011201
Velnacrine thiaanalogues as potential agents for treating Alzheimer's disease. Bioorganic & medicinal chemistry 20011101
Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells. Planta medica 20011101
Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat. Japanese journal of pharmacology 20011101
A structure-based design approach to the development of novel, reversible AChE inhibitors. Journal of medicinal chemistry 20010927
Peripheral and dual binding site acetylcholinesterase inhibitors: implications in treatment of Alzheimer's disease. Mini reviews in medicinal chemistry 20010901
Meta-analysis of ordinal outcomes using individual patient data. Statistics in medicine 20010815
Medications for the treatment of Alzheimer's disease. The Journal of the Oklahoma State Medical Association 20010801
Maintaining functional and behavioral abilities in Alzheimer disease. Alzheimer disease and associated disorders 20010801
Effects of bis(7)-tacrine on spontaneous synaptic activity and on the nicotinic ACh receptor of Torpedo electric organ. Journal of neurophysiology 20010701
Use of cholinesterase inhibitors for treatment of Alzheimer disease. Cleveland Clinic journal of medicine 20010701
Apoptosis: biphasic dose responses. Critical reviews in toxicology 20010701
Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats. Acta pharmacologica Sinica 20010701
Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease. Mini reviews in medicinal chemistry 20010701
[Effect of dimethyl diphenyl bicarboxylate (DDB) on 9-amino-1,2,3,4-tetrahydroacridine-induced hepatotoxicity in mice]. Yao xue xue bao = Acta pharmaceutica Sinica 20010701
Does 'butyrylization' of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase? Biochemistry 20010626
Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. Molecules and cells 20010430
Action of tacrine on muscarinic receptors in rat intestinal smooth muscle. Journal of autonomic pharmacology 20010401
Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats. European journal of pharmacology 20010301
Ion-exchange fibers and drugs: an equilibrium study. Journal of controlled release : official journal of the Controlled Release Society 20010129
Responder characteristics to a single oral dose of cholinesterase inhibitor: a double-blind placebo-controlled study with tacrine in Alzheimer patients. Dementia and geriatric cognitive disorders 20010101
Reversal of Haemorrhagic Shock in Rats by Tetrahydroaminoacridine. Pharmacology 20010101
Synthesis and in-vitro anticancer evaluation of bis-tacrine congeners. The Journal of pharmacy and pharmacology 20010101
Cholinesterase inhibitors for Alzheimer's disease. Drugs 20010101
[Ursodeoxycholic acid and prevention of tacrine-induced hepatotoxicity: a pilot study]. Therapie 20010101
Chronic donepezil treatment is associated with slowed cognitive decline in Alzheimer's disease. Dementia and geriatric cognitive disorders 20010101
Controlled release tacrine delivery system for the treatment of Alzheimer's disease. Drug delivery 20010101
Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype. Journal of neural transmission (Vienna, Austria : 1996) 20010101
[Current strategies of pathogenetic therapy of Alzheimer's disease]. Vestnik Rossiiskoi akademii meditsinskikh nauk 20010101
Evaluation of cholinergic treatment in demented patients by P300 evoked related potentials. Neurologia i neurochirurgia polska 20010101
Drugs used for cognitive symptoms of Alzheimer's disease. Perspectives in psychiatric care 20010101
Tacrine, a reversible acetylcholinesterase inhibitor, induces myopathy. Neuroreport 20000427
Cholinesterase inhibition for Alzheimer disease: a meta-analysis of the tacrine trials. Dementia Trialists' Collaboration. JAMA 19981125
[Convulsive crisis as a possible adverse reaction to the treatment with tacrine in Alzheimer's disease]. Medicina clinica 19980912
Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine. European journal of pharmacology 19980522
Central cardiovascular effects of tacrine in the conscious dog: a role for catecholamines and vasopressin release. European journal of pharmacology 19980508
Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268). Pharmacology, biochemistry, and behavior 19980401
Myoclonus induced by tacrine. Journal of neurology, neurosurgery, and psychiatry 19980201
Systemic administration of N omega-nitro-L-arginine methyl ester and indomethacin reduces the elevation of brain PGE2 content and prevents seizures and hippocampal damage evoked by LiCl and tacrine in rat. Experimental neurology 19980201
Motor dysfunction produced by tacrine administration in rats. Pharmacology, biochemistry, and behavior 19971201
Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia. Methods and findings in experimental and clinical pharmacology 19970501
Tremulous jaw movements produced by acute tacrine administration: possible relation to parkinsonian side effects. Pharmacology, biochemistry, and behavior 19970201
Adverse interaction of tacrine and haloperidol. The American journal of psychiatry 19961101
[Flare-up of arterial hypertension during treatment with tacrine]. Presse medicale (Paris, France : 1983) 19961012
Tacrine interacts with an allosteric activator site on alpha 4 beta 2 nAChRs in M10 cells. Neuroreport 19960902
Delirium caused by tacrine and ibuprofen interaction. The American journal of psychiatry 19960601
Convulsive effects of tacrine. Lancet (London, England) 19960511
Systemic administration of lithium chloride and tacrine but not kainic acid augments citrulline content of rat brain. European journal of pharmacology 19951227
Severe parkinsonian symptom development on combination treatment with tacrine and haloperidol. Journal of clinical psychopharmacology 19950801
Lack of involvement of nitric oxide in the mechanisms of seizures and hippocampal damage produced by kainate and ouabain in rats. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 19950301
Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in rats. European journal of pharmacology 19931130
Tacrine inhibits ventricular fibrillation induced by ischaemia and reperfusion and widens QT interval in rat. Cardiovascular research 19930301
Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats. Psychopharmacology 19920101
A comparison of the effects of cholinergic and dopaminergic agents on scopolamine-induced hyperactivity in mice. The Journal of pharmacology and experimental therapeutics 19901101
Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes. European journal of pharmacology 19891128
Suxamethonium apnoea masked by tetrahydroaminacrine. Anaesthesia 19780101

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