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CAS No: 1684-40-8 Catalog No: AG001Y1M MDL No:MFCD00012657
Title | Journal |
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Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca²⁺ overload. | Bioorganic & medicinal chemistry 20121101 |
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease. | Bioorganic & medicinal chemistry letters 20121015 |
Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects. | The Journal of biological chemistry 20121005 |
O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation. | Bioorganic & medicinal chemistry 20121001 |
Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease. | European journal of medicinal chemistry 20120901 |
Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins. | Brain research 20120827 |
Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo. | Journal of medicinal chemistry 20120614 |
Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: involvement in hippocampal neuronal loss in Alzheimer's disease. | Neurobiology of disease 20120601 |
Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and hepatoprotective properties in tacrine-treated HepG2 cells. | Journal of agricultural and food chemistry 20120530 |
Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors. | Journal of medicinal chemistry 20120510 |
Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids. | Bioorganic & medicinal chemistry 20120501 |
Solid-state characterization of tacrine hydrochloride. | Journal of pharmaceutical and biomedical analysis 20120407 |
Effect of bis(7)-tacrine on cognition in rats with chronic cerebral ischemia. | Neuroscience letters 20120323 |
Affinity binding-guided fluorescent nanobiosensor for acetylcholinesterase inhibitors via distance modulation between the fluorophore and metallic nanoparticle. | Analytical chemistry 20120320 |
Pharmacokinetics and brain dispositions of tacrine and its major bioactive monohydroxylated metabolites in rats. | Journal of pharmaceutical and biomedical analysis 20120305 |
Tacrine and its analogues impair mitochondrial function and bioenergetics: a lipidomic analysis in rat brain. | Journal of neurochemistry 20120301 |
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties. | Journal of medicinal chemistry 20120209 |
Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. | Neuropharmacology 20120201 |
Tanshinone I increases CYP1A2 protein expression and enzyme activity in primary rat hepatocytes. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20120115 |
Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents. | Neuro-degenerative diseases 20120101 |
Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo. | PloS one 20120101 |
2,3-dihydro-1H-cyclopenta[b]quinoline derivatives as acetylcholinesterase inhibitors-synthesis, radiolabeling and biodistribution. | International journal of molecular sciences 20120101 |
A single-center, randomized, open-label, dose-escalation study to evaluate the pharmacokinetics of tacrine analogue octahydrogenacridine succinate tablets in healthy Chinese subjects. | Biological & pharmaceutical bulletin 20120101 |
An electrochemical platform for acetylcholinesterase activity assay and inhibitors screening based on Michael addition reaction between thiocholine and catechol-terminated SAMs. | The Analyst 20111207 |
Cognitive dysfunctions induced by a cholinergic blockade and Aβ 25-35 peptide are attenuated by salvianolic acid B. | Neuropharmacology 20111201 |
Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway. | Neurochemistry international 20111201 |
Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues. | European journal of medicinal chemistry 20111201 |
Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease. | Current topics in medicinal chemistry 20111101 |
Effective pharmacological management of Alzheimer's disease. | The American journal of managed care 20111101 |
ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor. | Behavioural brain research 20111010 |
Tacrine and bis(7)-tacrine attenuate cycloheximide-induced amnesia in mice, with attention to acute toxicity. | Basic & clinical pharmacology & toxicology 20111001 |
Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice. | Fitoterapia 20111001 |
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors. | European journal of medicinal chemistry 20111001 |
Reversible human serum albumin binding of lipocrine: a circular dichroism study. | Chirality 20111001 |
Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice. | Planta medica 20110901 |
Reversible inhibition of esterase activity after separation and immobilization. | Applied biochemistry and biotechnology 20110901 |
Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors. | European journal of medicinal chemistry 20110801 |
Synthesis and biological activity of derivatives of tetrahydroacridine as acetylcholinesterase inhibitors. | Bioorganic chemistry 20110801 |
New drugs for Alzheimer's disease in Japan. | Psychiatry and clinical neurosciences 20110801 |
Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity. | European journal of pharmacology 20110625 |
HFE polymorphisms affect cellular glutamate regulation. | Neurobiology of aging 20110601 |
Tacrine treatment at high dose suppresses the recognition memory in juvenile and adult mice with attention to hepatotoxicity. | Basic & clinical pharmacology & toxicology 20110601 |
Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents. | European journal of medicinal chemistry 20110601 |
Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines. | Bioorganic & medicinal chemistry letters 20110415 |
Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and Aβ-aggregation inhibitors. | Bioorganic & medicinal chemistry 20110401 |
Inhibition mechanism of rat α₃β₄ nicotinic acetylcholine receptor by the Alzheimer therapeutic tacrine. | Biochemistry 20110322 |
Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. | Drug metabolism and disposition: the biological fate of chemicals 20110301 |
Clicked tacrine conjugates as acetylcholinesterase and β-amyloid directed compounds. | Organic & biomolecular chemistry 20110221 |
Acetylcholinesterase inhibitors partially generalize to nicotine discriminative stimulus effect in rats. | Behavioural pharmacology 20110201 |
Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation. | Bioorganic & medicinal chemistry 20110115 |
Potency determinations of acetylcholinesterase inhibitors using Ellman's reaction-based assay in screening: Effect of assay variants. | Analytical biochemistry 20110101 |
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles. | Bioorganic & medicinal chemistry 20110101 |
[Comparative sensitivity of liver monoamine oxidases of frog and whitefish to some tricyclic compounds]. | Zhurnal evoliutsionnoi biokhimii i fiziologii 20110101 |
In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain. | Neuro endocrinology letters 20110101 |
Diabetes-induced central cholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription, kangen-karyu: elucidation in type 2 diabetes db/db mice. | Journal of pharmacological sciences 20110101 |
Sensitizing effect of tacrine on M-cholinergic receptors in gastric smooth muscle of rats. | Folia medica 20110101 |
Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state. | Journal of the American Chemical Society 20101229 |
Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment. | Molecules (Basel, Switzerland) 20101202 |
Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands. | Analytical biochemistry 20101201 |
Action potential bursts in central snail neurons elicited by procaine: roles of ionic currents. | The Chinese journal of physiology 20101031 |
Design, synthesis, and molecular-modeling study of aminothienopyridine analogues of tacrine for Alzheimer's disease. | Archiv der Pharmazie 20101001 |
Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia. | Journal of natural products 20100924 |
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates. | Chemico-biological interactions 20100906 |
Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities. | ChemMedChem 20100802 |
Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties. | Journal of medicinal chemistry 20100708 |
Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin. | The Journal of biological chemistry 20100625 |
Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats. | Neurobiology of aging 20100601 |
A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's disease. | Neurotoxicity research 20100501 |
Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors. | Journal of medicinal chemistry 20100311 |
Differential effects of systemic and intraseptal administration of the acetylcholinesterase inhibitor tacrine on the recovery of spatial behavior in an animal model of diencephalic amnesia. | European journal of pharmacology 20100310 |
A novel animal model to evaluate the ability of a drug delivery system to promote the passage through the BBB. | Neuroscience letters 20100118 |
Tribuli fructus constituents protect against tacrine-induced cytotoxicity in HepG2 cells. | Archives of pharmacal research 20100101 |
Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage. | BMC neuroscience 20100101 |
Tacrine derivatives and Alzheimer's disease. | Current medicinal chemistry 20100101 |
Tacrine-NO donor and tacrine-ferulic acid hybrid molecules as new anti-Alzheimer agents: hepatotoxicity and influence on the cytochrome P450 system in comparison to tacrine. | Arzneimittel-Forschung 20100101 |
Investigation into the in vivo effects of five novel tacrine/ferulic acid and beta-carboline derivatives on scopolamine-induced cognitive impairment in rats using radial maze paradigm. | Arzneimittel-Forschung 20100101 |
Rapid determination of tacrine and other drug metabolites in microsomal incubate by newly developed targeting algorithm on UHPLC/TOFMS. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091215 |
Object location memory in mice: pharmacological validation and further evidence of hippocampal CA1 participation. | Behavioural brain research 20091201 |
Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently. | European journal of pharmacology 20091125 |
Differential effects of adenosine antagonists in two models of parkinsonian tremor. | Pharmacology, biochemistry, and behavior 20091101 |
Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2. | Toxicology and applied pharmacology 20091101 |
Long-lasting decreases in cocaine-reinforced behavior following treatment with the cholinesterase inhibitor tacrine in rats selectively bred for drug self-administration. | Pharmacology, biochemistry, and behavior 20091101 |
Ximelagatran increases membrane fluidity and changes membrane lipid composition in primary human hepatocytes. | Toxicology in vitro : an international journal published in association with BIBRA 20091001 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
Chromone glycosides and hepatoprotective constituents of Hypericum erectum. | Archives of pharmacal research 20091001 |
The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain. | Biochimie 20090901 |
The inhibitory avoidance test optimized for discovery of cognitive enhancers. | Behavior research methods 20090801 |
Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons. | Neuropharmacology 20090701 |
Identification of FDA-approved drugs and bioactives that protect hair cells in the zebrafish (Danio rerio) lateral line and mouse (Mus musculus) utricle. | Journal of the Association for Research in Otolaryngology : JARO 20090601 |
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. | Journal of medicinal chemistry 20090514 |
Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties. | ChemMedChem 20090501 |
Kinetics of inhibition of acetylcholinesterase in the presence of acetonitrile. | The FEBS journal 20090401 |
Redox thiol status plays a central role in the mobilization and metabolism of nitric oxide in human red blood cells. | Cell biology international 20090301 |
Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation. | Biological & pharmaceutical bulletin 20090301 |
Modulation of erythrocyte acetylcholinesterase activity and its association with G protein-band 3 interactions. | The Journal of membrane biology 20090301 |
[Progress in the research on multi-target-directed drugs against Alzheimer's disease]. | Yao xue xue bao = Acta pharmaceutica Sinica 20090301 |
Assessment of symptomatic and neuroprotective efficacy of Mucuna pruriens seed extract in rodent model of Parkinson's disease. | Neurotoxicity research 20090201 |
Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors. | Biochemistry 20090127 |
Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect. | Parkinsonism & related disorders 20090101 |
Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets. | Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20090101 |
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond. | Current pharmaceutical design 20090101 |
Inhibitory potency of choline esterase inhibitors on acetylcholine release and choline esterase activity in fresh specimens of human and rat neocortex. | Journal of Alzheimer's disease : JAD 20090101 |
Comparison studies of tacrine and bis7-tacrine on the suppression of scopolamine-induced behavioral changes and inhibition of acetylcholinesterase in mice. | Pharmacology 20090101 |
NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity. | Journal of medicinal chemistry 20081225 |
[Protection effects of acetylcholinesterase inhibitors on apoptosis]. | Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20081201 |
A universal method for fishing target proteins from mixtures of biomolecules using isothermal titration calorimetry. | Protein science : a publication of the Protein Society 20081001 |
New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrine. | Neuro endocrinology letters 20081001 |
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point. | Journal of pharmaceutical and biomedical analysis 20080910 |
An algorithm for thorough background subtraction from high-resolution LC/MS data: application for detection of glutathione-trapped reactive metabolites. | Journal of mass spectrometry : JMS 20080901 |
Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. | American journal of physiology. Gastrointestinal and liver physiology 20080901 |
Weak intermolecular interactions in 11-chloro-2,3,4,5-tetrahydro-1H-cyclohepta[b]quinoline. | Acta crystallographica. Section C, Crystal structure communications 20080901 |
Extracts and constituents of Leontopodium alpinum enhance cholinergic transmission: brain ACh increasing and memory improving properties. | Biochemical pharmacology 20080715 |
Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia. | Neuroscience letters 20080711 |
MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats. | Journal of neural transmission (Vienna, Austria : 1996) 20080701 |
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. | Journal of medicinal chemistry 20080626 |
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors. | Journal of medicinal chemistry 20080612 |
Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies. | Neuropharmacology 20080601 |
Antipsychotic-like behavioral effects and cognitive enhancement by a potent and selective muscarinic M-sub-1 receptor agonist, AC-260584. | Behavioral neuroscience 20080601 |
Effects of tamoxifen on L-glutamate transporters of astrocytes. | Journal of pharmacological sciences 20080601 |
The cholinergic system in cyclophosphamide-induced Chagas dilated myocardiopathy in Trypanosoma-cruzi-infected rats: an electrocardiographic study. | Investigacion clinica 20080601 |
Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors. | Biochemical and biophysical research communications 20080516 |
Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates. | Bioorganic & medicinal chemistry letters 20080501 |
In vitro hepatoprotective compounds from Suaeda glauca. | Archives of pharmacal research 20080501 |
Diagnosis and treatment of dementia with Lewy bodies. | JAAPA : official journal of the American Academy of Physician Assistants 20080501 |
AAFP and ACP release guideline on dementia treatment. | American family physician 20080415 |
Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry. | Biomedical chromatography : BMC 20080401 |
Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice. | European journal of pharmacology 20080310 |
Summaries for patients. Drug treatment for patients with dementia: American College of Physicians and American Academy of Family Physicians recommendations. | Annals of internal medicine 20080304 |
Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians. | Annals of internal medicine 20080304 |
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. | Annals of internal medicine 20080304 |
Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity. | Biochemical and biophysical research communications 20080215 |
Effect of tacrine, amiridine, akatinol memantine, and triazolam on phosphorylation, structure, and assembly of microtubules from brain microtubular proteins in Alzheimer diseases. | Bulletin of experimental biology and medicine 20080201 |
The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine. | Journal of pharmaceutical and biomedical analysis 20080107 |
Effects of zonisamide on experimental tremors in rats. | Parkinsonism & related disorders 20080101 |
Dose-related effects of the acetylcholinesterase inhibitor tacrine on cocaine and food self-administration in rats. | Psychopharmacology 20080101 |
Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions. | PloS one 20080101 |
Hepatoprotective effect of Cirsium arisanense Kitamura in tacrine-treated hepatoma Hep 3B cells and C57BL mice. | The American journal of Chinese medicine 20080101 |
Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds. | Journal of pharmacological and toxicological methods 20080101 |
Modulation of hemorheological parameters by the erythrocyte redox thiol status. | Clinical hemorheology and microcirculation 20080101 |
Non-neuronal cholinergic system and signal transduction pathways mediated by band 3 in red blood cells. | Clinical hemorheology and microcirculation 20080101 |
Protective effect of reversible cholinesterase inhibitors (tacrine, pyridostigmine) and eqbuche against VX poisoning and brain acetylcholinesterase inhibition in rats. | Acta medica (Hradec Kralove) 20080101 |
A new acetylcholinesterase inhibitor with anti-PAF activity modulates oxidative stress and pro-inflammatory mediators release in stimulated RAW 264.7 macrophage cells. Comparison with tacrine. | International immunopharmacology 20071215 |
Tacrine-induced liver damage: an analysis of 19 candidate genes. | Pharmacogenetics and genomics 20071201 |
First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor. | Journal of medicinal chemistry 20071115 |
Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. | Pharmacogenetics and genomics 20071101 |
Thermodynamic analysis of binding between drugs and glycosaminoglycans by isothermal titration calorimetry and fluorescence spectroscopy. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071001 |
Evaluation of centrally acting cholinesterase inhibitor exposures in adults. | The Annals of pharmacotherapy 20071001 |
Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents. | Biochemical and biophysical research communications 20070921 |
Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood. | Journal of pharmaceutical and biomedical analysis 20070903 |
Alzheimer's disease: will advances made in the past turn the tide? | The Annals of pharmacotherapy 20070901 |
Nose-to-brain delivery of tacrine. | The Journal of pharmacy and pharmacology 20070901 |
The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice. | Journal of pharmacological sciences 20070901 |
East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A. | Current Alzheimer research 20070901 |
Treating autism pharmacologically: also tacrine might improve symptomatology in some cases. | Journal of child neurology 20070801 |
WITHDRAWN: Tacrine for Alzheimer's disease. | The Cochrane database of systematic reviews 20070718 |
Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats. | European journal of pharmacology 20070702 |
Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons. | Journal of proteome research 20070701 |
Effect of histamine on muscimol-induced working memory deficits in radial maze performance. | Journal of pharmacological sciences 20070701 |
Cytoprotective constituent of Hoveniae Lignum on both Hep G2 cells and rat primary hepatocytes. | Archives of pharmacal research 20070601 |
Cholinesterase inhibitors reduce cortical Abeta in dementia with Lewy bodies. | Neurology 20070515 |
Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase. | Molecular pharmacology 20070501 |
Effect of anti-dementia drugs on LPS induced neuroinflammation in mice. | Life sciences 20070501 |
Mutational disruption of a conserved disulfide bond in muscarinic acetylcholine receptors attenuates positive homotropic cooperativity between multiple allosteric sites and has subtype-dependent effects on the affinities of muscarinic allosteric ligands. | Molecular pharmacology 20070301 |
The application of evidence-based principles of care in older persons (issue 5): Alzheimer's disease. | Journal of the American Medical Directors Association 20070301 |
Alkylene tether-length dependent gamma-aminobutyric acid type A receptor competitive antagonism by tacrine dimers. | Neuropharmacology 20070201 |
Screening of acetylcholinesterase inhibitors in natural extracts by CE with electrophoretically mediated microanalysis technique. | Electrophoresis 20070201 |
Re-evaluation of tacrine hepatotoxicity using gel entrapped hepatocytes. | Toxicology letters 20070130 |
Effects of velnacrine maleate in the leukocyte-endothelial cell interactions in rat cremaster microcirculatory network. | Clinical hemorheology and microcirculation 20070101 |
Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment. | Current medicinal chemistry 20070101 |
Long-term tetrahydroaminoacridine treatment and quantitative EEG in Alzheimer's disease. | Journal of neural transmission. Supplementum 20070101 |
Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease. | Journal of medicinal chemistry 20061228 |
New multipotent tetracyclic tacrines with neuroprotective activity. | Bioorganic & medicinal chemistry 20061215 |
Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase. | Journal of medicinal chemistry 20061214 |
Fluorescent method for evaluation of cholinesterase inhibitors. | Bulletin of experimental biology and medicine 20061201 |
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole. | Journal of medicinal chemistry 20061116 |
Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity. | European journal of pharmacology 20061107 |
Calcium-independent tacrine-induced relaxation of rat gastric corpus smooth muscles. | Canadian journal of physiology and pharmacology 20061101 |
Rapid method for evaluation of cholinesterase inhibitors. | Bulletin of experimental biology and medicine 20061101 |
Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease. | Journal of the neurological sciences 20061025 |
Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease. | Journal of molecular graphics & modelling 20061001 |
Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase. | Journal of medicinal chemistry 20060907 |
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge. | Journal of medicinal chemistry 20060907 |
Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells. Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairment. | Toxicology in vitro : an international journal published in association with BIBRA 20060901 |
Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels. | Journal of neurochemistry 20060901 |
Evaluation of acute tacrine treatment on passive-avoidance response, open-field behavior, and toxicity in 17- and 30-day-old mice. | Pharmacology, biochemistry, and behavior 20060901 |
Inhibition of two different cholinesterases by tacrine. | Chemico-biological interactions 20060825 |
[Mechanisms of neuroprotective effects of therapeutic acetylcholinesterase inhibitors used in treatment of Alzheimer's disease]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060801 |
Cover note article on the muscle relaxants suxamethonium and THA. | Anaesthesia and intensive care 20060801 |
Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease. | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20060701 |
Choline pivaloyl ester strengthened the benefit effects of Tacrine and Galantamine on electroencephalographic and cognitive performances in nucleus basalis magnocellularis-lesioned and aged rats. | Pharmacology, biochemistry, and behavior 20060701 |
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites. | Journal of medicinal chemistry 20060601 |
Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine. | Neuroreport 20060403 |
Olfactory nerve-evoked, metabotropic glutamate receptor-mediated synaptic responses in rat olfactory bulb mitral cells. | Journal of neurophysiology 20060401 |
New tacrine-hydrazinonicotinamide hybrids as acetylcholinesterase inhibitors of potential interest for the early diagnostics of Alzheimer's disease. | Die Pharmazie 20060401 |
Muscle relaxants--suxamethonium and THA. | Anaesthesia and intensive care 20060201 |
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties. | Journal of medicinal chemistry 20060126 |
Memory-dependent novelty-related location preferences: sex-related attenuation of forgetting by D-glucose and tacrine. | Behavioural brain research 20060106 |
Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine. | Journal of peptide science : an official publication of the European Peptide Society 20060101 |
Chronic exposure of rats to cognition enhancing drugs produces a neuroplastic response identical to that obtained by complex environment rearing. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060101 |
CSF biomarkers for Alzheimer's Disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival. | Dementia and geriatric cognitive disorders 20060101 |
Long-term depression of neuron to glial signalling in rat cerebellar cortex. | The European journal of neuroscience 20060101 |
Automated method, based on micro-sequential injection, for the study of enzyme kinetics and inhibition. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060101 |
Current and emerging pharmacological treatment options for dementia. | Behavioural neurology 20060101 |
Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease. | Alzheimer disease and associated disorders 20060101 |
Pharmacological characterization of orally active cholinesterase inhibitory activity of Prunus persica L. Batsch in rats. | Journal of molecular neuroscience : MN 20060101 |
Alzheimer disease and its management: a review. | American journal of therapeutics 20060101 |
Effect of tacrine on cytosolic Ca2+ level and calmodulin in gastric muscle tissues of rat. | Folia medica 20060101 |
Induced fit in mouse acetylcholinesterase upon binding a femtomolar inhibitor: a molecular dynamics study. | Journal of medicinal chemistry 20051229 |
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE. | Bioorganic & medicinal chemistry 20051215 |
Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors. | Molecular pharmacology 20051201 |
Allosteric binding sites on muscarinic acetylcholine receptors. | Molecular pharmacology 20051201 |
Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine-induced cytotoxicity in Hep G2 cells. | Archives of pharmacal research 20051201 |
Intestinal single-pass in situ perfusion technique in rat: the influence of L-carnitine on absorption of 7-methoxytacrine. | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201 |
Dementia. | Clinical evidence 20051201 |
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease. | Journal of medicinal chemistry 20051117 |
Random chemistry as a new tool for the generation of small compound libraries: development of a new acetylcholinesterase inhibitor. | Journal of medicinal chemistry 20051117 |
Phenolic constituents of galla Rhois with hepatoprotective effects on tacrine- and nitrofurantoin-induced cytotoxicity in Hep G2 cells. | Biological & pharmaceutical bulletin 20051101 |
Structural basis for inhibition of histamine N-methyltransferase by diverse drugs. | Journal of molecular biology 20051021 |
Modulation of spontaneous alternation performance of mice treated with thioperamide and tacrine in a cross maze task. | Fundamental & clinical pharmacology 20051001 |
Evidence for the involvement of central serotonergic mechanisms in cholinergic tremor induced by tacrine in Balb/c mice. | Behavioural brain research 20050908 |
Consumption of charcoal-broiled meat as an experimental tool for discerning CYP1A2-mediated drug metabolism in vivo. | Basic & clinical pharmacology & toxicology 20050901 |
SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist, alleviates disturbances of novelty discrimination in a social context in rats, a putative model of selective attention deficit. | Psychopharmacology 20050801 |
Modification of motor cortical excitability by an acetylcholinesterase inhibitor. | Experimental brain research 20050701 |
In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors. | Journal of the American Chemical Society 20050511 |
Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors. | The Journal of biological chemistry 20050506 |
Quetiapine (Seroquel) shows a pattern of behavioral effects similar to the atypical antipsychotics clozapine and olanzapine: studies with tremulous jaw movements in rats. | Psychopharmacology 20050501 |
Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production. | Annals of neurology 20050501 |
Role of molecular isoforms of acetylcholinesterase in learning and memory functions. | Pharmacology, biochemistry, and behavior 20050501 |
Actions of tacrine and galanthamine on histamine-N-methyltransferase. | Methods and findings in experimental and clinical pharmacology 20050401 |
Donepezil, tacrine and alpha-phenyl-n-tert-butyl nitrone (PBN) inhibit choline transport by conditionally immortalized rat brain capillary endothelial cell lines (TR-BBB). | Archives of pharmacal research 20050401 |
Saturable distribution of tacrine into the striatal extracellular fluid of the rat: evidence of involvement of multiple organic cation transporters in the transport. | Drug metabolism and disposition: the biological fate of chemicals 20050301 |
Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine. | European journal of medicinal chemistry 20050301 |
Pharmacologic treatment options in Alzheimer's disease: optimizing disease management. | Journal of the American Academy of Nurse Practitioners 20050301 |
Is donepezil therapy associated with reduced mortality in nursing home residents with dementia? | The American journal of geriatric pharmacotherapy 20050301 |
Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism. | European journal of pharmacology 20050221 |
Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243. | Behavioural brain research 20050130 |
Rational approach to discover multipotent anti-Alzheimer drugs. | Journal of medicinal chemistry 20050127 |
The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane. | British journal of pharmacology 20050101 |
Synthesis and biological evaluation of tacrine-thiadiazolidinone hybrids as dual acetylcholinesterase inhibitors. | Archiv der Pharmazie 20050101 |
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Non-anticholinesterase, non-cholinergic effect of tacrine on gastrointestinal smooth muscle tissues of rat. | Folia medica 20050101 |
In vitro inactivation of rat brain acetylcholinesterase by DSP-4 and its derivatives OS-21 and OS-23 and protective activity of tacrine (9-amino-1,2,3,4-tetrahydroacridine). | Acta medica (Hradec Kralove) 20050101 |
(+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration. | Journal of Alzheimer's disease : JAD 20041201 |
Dementia. | Clinical evidence 20041201 |
Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens. | European journal of pharmacology 20041025 |
Within-subject memory decline in middle-aged rats: effects of intraseptal tacrine. | Neurobiology of aging 20041001 |
A prospective randomized double masked controlled clinical trial to determine the efficacy of multiple drop centbucridine as an ocular surface anaesthetic. | Indian journal of physiology and pharmacology 20041001 |
A water extract of Curcuma longa L. (Zingiberaceae) rescues PC12 cell death caused by pyrogallol or hypoxia/reoxygenation and attenuates hydrogen peroxide induced injury in PC12 cells. | Life sciences 20040924 |
Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. | Bioorganic & medicinal chemistry letters 20040920 |
ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a novel acetylcholinesterase inhibitor with 'calcium promotor' and neuroprotective properties. | The Journal of pharmacology and experimental therapeutics 20040901 |
Blockade of adenosine A2A receptors antagonizes parkinsonian tremor in the rat tacrine model by an action on specific striatal regions. | Experimental neurology 20040901 |
Tetrahydroacridine inhibits voltage-dependent Na(+) current in guinea-pig ventricular myocytes. | Acta pharmacologica Sinica 20040901 |
An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa. | Archives of pharmacal research 20040901 |
Alaternin and emodin with hydroxyl radical inhibitory and/or scavenging activities and hepatoprotective activity on tacrine-induced cytotoxicity in HepG2 cells. | Archives of pharmacal research 20040901 |
An investigation of the effect of tacrine and physostigmine on spatial working memory deficits in the olfactory bulbectomised rat. | Behavioural brain research 20040831 |
Inhibition of murine cytochrome P4501A by tacrine: in vitro studies. | Drug metabolism and disposition: the biological fate of chemicals 20040801 |
A latent normal distribution model for analysing ordinal responses with applications in meta-analysis. | Statistics in medicine 20040730 |
Nanosecond dynamics of acetylcholinesterase near the active center gorge. | The Journal of biological chemistry 20040618 |
Inhibition by bis(7)-tacrine of 5-HT-activated current in rat TG neurons. | Neuroreport 20040607 |
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Cholesterol and APOE genotype interact to influence Alzheimer disease progression. | Neurology 20040525 |
Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients. | Journal of neurochemistry 20040301 |
Influence of tacrine on dopamine-induced reactions of the gastric smooth muscle of rats. | Methods and findings in experimental and clinical pharmacology 20040301 |
Choline pivaloyl esters improve in rats cognitive and memory performances impaired by scopolamine treatment or lesions of the nucleus basalis of Meynert. | Neuroscience letters 20040219 |
Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease. | European journal of pharmacology 20040213 |
Simultaneous analysis of esterase and transferase activities in cytosol proteins from the bovine retina by using microscale non-denaturing two-dimensional electrophoresis. | Biochimica et biophysica acta 20040114 |
Differences between clinical trials and postmarketing use. | British journal of clinical pharmacology 20040101 |
Acetylcholinesterase inhibition in Alzheimer's Disease. | Current pharmaceutical design 20040101 |
Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel. | Archives of pharmacal research 20040101 |
Tetrahydroacridin-9-ones, 9-chlorotetrahydroacridines, 9-amino-tetrahydroacridines and 9-(pyrazol-1-yl)-tetrahydroacridines derived from chiral cyclanones. | European journal of medicinal chemistry 20040101 |
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Comparison of desorption/ionization on silicon (DIOS) time-of-flight and liquid chromatography/tandem mass spectrometry for assaying enzyme-inhibition reactions. | Rapid communications in mass spectrometry : RCM 20040101 |
The acetylcholinesterase inhibitors for treatment of cognitive and behavioral symptoms in dementia with Lewy bodies. | The Journal of neuropsychiatry and clinical neurosciences 20040101 |
Spectrofluorimetric determination of velnacrine in human serum and urine. | Farmaco (Societa chimica italiana : 1989) 20031201 |
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Inhibitors tethered near the acetylcholinesterase active site serve as molecular rulers of the peripheral and acylation sites. | The Journal of biological chemistry 20031003 |
Recent developments in the synthesis of acetylcholinesterase inhibitors. | Mini reviews in medicinal chemistry 20030901 |
Tacrine inhibits topoisomerases and DNA synthesis to cause mitochondrial DNA depletion and apoptosis in mouse liver. | Hepatology (Baltimore, Md.) 20030901 |
Benzodiazepine utilization patterns in Alzheimer's disease patients. | Pharmacoepidemiology and drug safety 20030901 |
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Photoreversible inhibition of cholinesterases: catalytic serine-labeled caged butyrylcholinesterase. | Chembiochem : a European journal of chemical biology 20030804 |
Flumazenil and tacrine increase the effectiveness of ondansetron on scopolamine-induced impairment of spatial learning in rats. | Psychopharmacology 20030801 |
Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus. | Journal of ethnopharmacology 20030801 |
Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors. | Molecular pharmacology 20030701 |
Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. | The Journal of pharmacology and experimental therapeutics 20030601 |
The clinical use of P300 event related potentials for the evaluation of cholinesterase inhibitors treatment in demented patients. | Journal of neural transmission (Vienna, Austria : 1996) 20030601 |
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Hepatoprotective phenolic constituents of Rhodiola sachalinensis on tacrine-induced cytotoxicity in Hep G2 cells. | Phytotherapy research : PTR 20030501 |
Mitochondria as a target for neurotoxins and neuroprotective agents. | Annals of the New York Academy of Sciences 20030501 |
Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition. | Chemistry & biology 20030401 |
Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy. | International clinical psychopharmacology 20030301 |
Acute effects of huperzine A and tacrine on rat liver. | Acta pharmacologica Sinica 20030301 |
Cerebral glucose metabolism, cerebrospinal fluid-beta-amyloid1-42 (CSF-Abeta42), tau and apolipoprotein E genotype in long-term rivastigmine and tacrine treated Alzheimer disease (AD) patients. | Neuroscience letters 20030227 |
Tacrine-scopolamine interactions on state-dependent retrieval. | Psychopharmacology 20030201 |
Hormone replacement therapy in postmenopausal women with Alzheimer's disease: a randomized, prospective study. | Fertility and sterility 20030201 |
Alzheimer's disease: emerging noncholinergic treatments. | Geriatrics 20030201 |
Local injections of the 5-hydroxytryptamine antagonist mianserin into substantia nigra pars reticulata block tremulous jaw movements in rats: studies with a putative model of Parkinsonian tremor. | Psychopharmacology 20030101 |
Centbucridine, a newer topical anaesthetic compared with lignocaine: a randomized double masked single drop instillation clinical trial. | Indian journal of physiology and pharmacology 20030101 |
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Involvement of reduced acetylcholine release in Delta9-tetrahydrocannabinol-induced impairment of spatial memory in the 8-arm radial maze. | Life sciences 20021220 |
Risk from lithium with acetylcholinesterase inhibitor. | Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20021201 |
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Tacrine attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells. | Brain research. Molecular brain research 20021030 |
In vivo and in vitro effects of aluminum on the activity of mouse brain acetylcholinesterase. | Brain research bulletin 20021015 |
Effect of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone fumarate, a novel acetylcholinesterase inhibitor, on spatial cognitive impairment induced by chronic cerebral hypoperfusion in rats. | Neuroscience letters 20021004 |
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Clinical use of cholinomimetic agents: a review. | The Journal of head trauma rehabilitation 20020801 |
Binding and release of drugs into and from thermosensitive poly(N-vinyl caprolactam) nanoparticles. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020701 |
Medical treatment of Alzheimer's disease: past, present, and future. | Medicine and health, Rhode Island 20020701 |
Nicotine and sensory memory in Alzheimer's disease: an event-related potential study. | Brain and cognition 20020701 |
Electroencephalographic activation by tacrine, deprenyl, and quipazine: cholinergic vs. non-cholinergic contributions. | European journal of pharmacology 20020628 |
Novel tacrine derivatives that block neuronal calcium channels. | Bioorganic & medicinal chemistry 20020601 |
Acute and chronic acetylcholinesterase inhibition regulates in vivo the localization and abundance of muscarinic receptors m2 and m4 at the cell surface and in the cytoplasm of striatal neurons. | Molecular and cellular neurosciences 20020601 |
Acute nicotine effects on auditory sensory memory in tacrine-treated and nontreated patients with Alzheimer's disease: an event-related potential study. | Pharmacology, biochemistry, and behavior 20020501 |
Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells. | Planta medica 20020501 |
Determination of tacrine metabolites in microsomal incubate by high performance liquid chromatography-nuclear magnetic resonance/mass spectrometry with a column trapping system. | Journal of pharmaceutical and biomedical analysis 20020401 |
Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents. | The Journal of pharmacology and experimental therapeutics 20020401 |
Reversal of scopolamine-induced spatial memory deficits in rats by TAK-147. | Acta pharmacologica Sinica 20020401 |
3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates. | Biochemistry 20020305 |
Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice. | Planta medica 20020301 |
Chronic treatments with tacrine and (-)-nicotine induce different changes of nicotinic and muscarinic acetylcholine receptors in the brain of aged rat. | Journal of neural transmission (Vienna, Austria : 1996) 20020301 |
Abnormal expression of neuronal nitric oxide synthase triggers limbic seizures and hippocampal damage in rat. | Biochemical and biophysical research communications 20020222 |
Electroencephalographic activation by fluoxetine in rats: role of 5-HT(1A) receptors and enhancement of concurrent acetylcholinesterase inhibitor treatment. | Neuropharmacology 20020201 |
Effects of amphetamine on the plus-maze discriminative avoidance task in mice. | Psychopharmacology 20020201 |
Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain. | Japanese journal of pharmacology 20020201 |
[Protective effects of tacrine and donepezil against staurosporine-induced apoptotic death]. | Yao xue xue bao = Acta pharmaceutica Sinica 20020201 |
Safety and efficacy of idebenone versus tacrine in patients with Alzheimer's disease: results of a randomized, double-blind, parallel-group multicenter study. | Pharmacopsychiatry 20020101 |
Effects of acute nicotine administration on cognitive event-related potentials in tacrine-treated and non-treated patients with Alzheimer's disease. | Neuropsychobiology 20020101 |
Understanding and managing behavioural symptoms in Alzheimer's disease and related dementias: focus on rivastigmine. | Current medical research and opinion 20020101 |
Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors. | Clinical pharmacokinetics 20020101 |
Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors. | Journal of medicinal chemistry 20011220 |
Steroid hormones mediate sex difference in brain levels of tacrine and its hypothermic effect in the rat. | Neuropharmacology 20011201 |
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Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells. | Planta medica 20011101 |
Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat. | Japanese journal of pharmacology 20011101 |
A structure-based design approach to the development of novel, reversible AChE inhibitors. | Journal of medicinal chemistry 20010927 |
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Medications for the treatment of Alzheimer's disease. | The Journal of the Oklahoma State Medical Association 20010801 |
Maintaining functional and behavioral abilities in Alzheimer disease. | Alzheimer disease and associated disorders 20010801 |
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Use of cholinesterase inhibitors for treatment of Alzheimer disease. | Cleveland Clinic journal of medicine 20010701 |
Apoptosis: biphasic dose responses. | Critical reviews in toxicology 20010701 |
Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats. | Acta pharmacologica Sinica 20010701 |
Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease. | Mini reviews in medicinal chemistry 20010701 |
[Effect of dimethyl diphenyl bicarboxylate (DDB) on 9-amino-1,2,3,4-tetrahydroacridine-induced hepatotoxicity in mice]. | Yao xue xue bao = Acta pharmaceutica Sinica 20010701 |
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Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. | Molecules and cells 20010430 |
Action of tacrine on muscarinic receptors in rat intestinal smooth muscle. | Journal of autonomic pharmacology 20010401 |
Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats. | European journal of pharmacology 20010301 |
Ion-exchange fibers and drugs: an equilibrium study. | Journal of controlled release : official journal of the Controlled Release Society 20010129 |
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Reversal of Haemorrhagic Shock in Rats by Tetrahydroaminoacridine. | Pharmacology 20010101 |
Synthesis and in-vitro anticancer evaluation of bis-tacrine congeners. | The Journal of pharmacy and pharmacology 20010101 |
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Controlled release tacrine delivery system for the treatment of Alzheimer's disease. | Drug delivery 20010101 |
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Drugs used for cognitive symptoms of Alzheimer's disease. | Perspectives in psychiatric care 20010101 |
Tacrine, a reversible acetylcholinesterase inhibitor, induces myopathy. | Neuroreport 20000427 |
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Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine. | European journal of pharmacology 19980522 |
Central cardiovascular effects of tacrine in the conscious dog: a role for catecholamines and vasopressin release. | European journal of pharmacology 19980508 |
Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268). | Pharmacology, biochemistry, and behavior 19980401 |
Myoclonus induced by tacrine. | Journal of neurology, neurosurgery, and psychiatry 19980201 |
Systemic administration of N omega-nitro-L-arginine methyl ester and indomethacin reduces the elevation of brain PGE2 content and prevents seizures and hippocampal damage evoked by LiCl and tacrine in rat. | Experimental neurology 19980201 |
Motor dysfunction produced by tacrine administration in rats. | Pharmacology, biochemistry, and behavior 19971201 |
Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia. | Methods and findings in experimental and clinical pharmacology 19970501 |
Tremulous jaw movements produced by acute tacrine administration: possible relation to parkinsonian side effects. | Pharmacology, biochemistry, and behavior 19970201 |
Adverse interaction of tacrine and haloperidol. | The American journal of psychiatry 19961101 |
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Tacrine interacts with an allosteric activator site on alpha 4 beta 2 nAChRs in M10 cells. | Neuroreport 19960902 |
Delirium caused by tacrine and ibuprofen interaction. | The American journal of psychiatry 19960601 |
Convulsive effects of tacrine. | Lancet (London, England) 19960511 |
Systemic administration of lithium chloride and tacrine but not kainic acid augments citrulline content of rat brain. | European journal of pharmacology 19951227 |
Severe parkinsonian symptom development on combination treatment with tacrine and haloperidol. | Journal of clinical psychopharmacology 19950801 |
Lack of involvement of nitric oxide in the mechanisms of seizures and hippocampal damage produced by kainate and ouabain in rats. | Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 19950301 |
Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in rats. | European journal of pharmacology 19931130 |
Tacrine inhibits ventricular fibrillation induced by ischaemia and reperfusion and widens QT interval in rat. | Cardiovascular research 19930301 |
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A comparison of the effects of cholinergic and dopaminergic agents on scopolamine-induced hyperactivity in mice. | The Journal of pharmacology and experimental therapeutics 19901101 |
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