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Home > Imidazoles > 165800-06-6

165800-06-6

165800-06-6 | Phosphonic acid, P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, hydrate (1:1)

CAS No: 165800-06-6 Catalog No: AG001WDF MDL No:MFCD08448695

Product Description

Catalog Number:
AG001WDF
Chemical Name:
Phosphonic acid, P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, hydrate (1:1)
CAS Number:
165800-06-6
Molecular Formula:
C5H12N2O8P2
Molecular Weight:
290.1049
MDL Number:
MFCD08448695
IUPAC Name:
(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid;hydrate
InChI:
InChI=1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2
InChI Key:
FUXFIVRTGHOMSO-UHFFFAOYSA-N
SMILES:
OP(=O)(C(P(=O)(O)O)(Cn1cncc1)O)O.O
UNII:
6XC1PAD3KF

Properties

Complexity:
327  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
290.007g/mol
Formal Charge:
0
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0
Molecular Weight:
290.105g/mol
Monoisotopic Mass:
290.007g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
154A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Literature

Title Journal
Interleukin-19 as a translational indicator of renal injury. Archives of toxicology 20150101
Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid. Biochimica et biophysica acta 20121201
Exposing human epithelial cells to zoledronic acid can mediate osteonecrosis of jaw: an in vitro model. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20121101
Zoledronic acid inhibits aromatase activity and phosphorylation: potential mechanism for additive zoledronic acid and letrozole drug interaction. The Journal of steroid biochemistry and molecular biology 20121101
The effect of systemically administrated zoledronic acid on the osseointegration of dental implants. Oral diseases 20121101
The impact of menopause on bone, zoledronic acid, and implications for breast cancer growth and metastasis. Annals of oncology : official journal of the European Society for Medical Oncology 20121101
Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: a combined analysis of 3 pivotal, randomised, phase 3 trials. European journal of cancer (Oxford, England : 1990) 20121101
(89)Sr imaging with bremsstrahlung in patients with metastatic breast cancer. Clinical nuclear medicine 20121101
Radiographic evaluation of maxillofacial region in oncology patients treated with bisphosphonates. Oral surgery, oral medicine, oral pathology and oral radiology 20121101
Fracture risk and zoledronic acid therapy in men with osteoporosis. The New England journal of medicine 20121101
Dysfunctional Vγ9Vδ2 T cells are negative prognosticators and markers of dysregulated mevalonate pathway activity in chronic lymphocytic leukemia cells. Blood 20121018
[Should we treat thalassemia-induced osteoporosis: two case reports]. Praxis 20121003
Incidence of maxillary sinusitis and oro-antral fistulae in bisphosphonate-related osteonecrosis of the jaw. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 20121001
Antiresorptive therapies in oncology and their effects on cancer progression. Cancer treatment reviews 20121001
Zoledronic acid suppresses mineralization through direct cytotoxicity and osteoblast differentiation inhibition. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20121001
Oncologic doses of zoledronic acid induce osteonecrosis of the jaw-like lesions in rice rats (Oryzomys palustris) with periodontitis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20121001
Early effects of zoledronic acid and teriparatide on bone microarchitecture, remodeling and collagen crosslinks: comparison between iliac crest and lumbar vertebra in ewes. Bone 20121001
Third-generation bisphosphonates for treatment of sensorineural hearing loss in otosclerosis. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20121001
Zoledronate sensitizes neuroblastoma-derived tumor-initiating cells to cytolysis mediated by human γδ T cells. Journal of immunotherapy (Hagerstown, Md. : 1997) 20121001
Acute anterior uveitis following zoledronic acid infusion for osteoporosis. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20121001
Persistence with intravenous zoledronate in elderly patients with osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120901
Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth. Cancer immunology, immunotherapy : CII 20120901
Analysis of molecular mechanisms and anti-tumoural effects of zoledronic acid in breast cancer cells. Journal of cellular and molecular medicine 20120901
Influence of zoledronic acid on disseminated tumor cells in primary breast cancer patients. Annals of oncology : official journal of the European Society for Medical Oncology 20120901
Zoledronic acid influences growth, migration and invasive activity of prostate cancer cells in vitro. Prostate cancer and prostatic diseases 20120901
Tooth extraction in patients on zoledronic acid therapy. Oral oncology 20120901
Renal complications from bisphosphonate treatment. Current opinion in supportive and palliative care 20120901
Transcriptome analysis and in vivo activity of fluvastatin versus zoledronic acid in a murine breast cancer metastasis model. Molecular pharmacology 20120901
Adjuvant bone-targeted therapy to prevent metastasis: lessons from the AZURE study. Current opinion in supportive and palliative care 20120901
Efficacy of intravenous zoledronic acid in the prevention and treatment of osteoporosis: a meta-analysis. Asian Pacific journal of tropical medicine 20120901
Preventing bone complications in prostate cancer. Current opinion in supportive and palliative care 20120901
Bone-related complications and quality of life in advanced breast cancer: results from a randomized phase III trial of denosumab versus zoledronic acid. Clinical cancer research : an official journal of the American Association for Cancer Research 20120901
[Therapeutic effect of zoledronic acid on primary osteoporosis in elderly patients]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120901
Feasibility study of zoledronic acid plus cisplatin-docetaxel as first-line treatment for advanced non-small cell lung cancer with bone metastases. Anticancer research 20120901
Denosumab and bone metastases. No better than a bisphosphonate. Prescrire international 20120901
Sensitization of ovarian carcinoma cells with zoledronate restores the cytotoxic capacity of Vγ9Vδ2 T cells impaired by the prostaglandin E2 immunosuppressive factor: implications for immunotherapy. International journal of cancer 20120815
Zoledronic acid, an aminobisphosphonate, prolongs survival of skin allografts. Clinical and investigative medicine. Medecine clinique et experimentale 20120804
Cytotoxicity of the new antimetabolite-bisphosphonate (5-FdU-alendronate) in comparison to standard therapeutics on breast and ovarian cancer cell lines in the ATP tumor chemosensitivity assay. Investigational new drugs 20120801
New treatment options for patients with metastatic castration-resistant prostate cancer. Cancer treatment reviews 20120801
Direct and indirect anticancer activity of bisphosphonates: a brief review of published literature. Cancer treatment reviews 20120801
Low concentration amino-bisphosphonates stimulate human keratinocyte proliferation and in vitro wound healing. International wound journal 20120801
Natural history of bone metastasis in colorectal cancer: final results of a large Italian bone metastases study. Annals of oncology : official journal of the European Society for Medical Oncology 20120801
Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial. Annals of the rheumatic diseases 20120801
Bone effect of adjuvant tamoxifen, letrozole or letrozole plus zoledronic acid in early-stage breast cancer: the randomized phase 3 HOBOE study. Annals of oncology : official journal of the European Society for Medical Oncology 20120801
Relationship of changes in total hip bone mineral density to vertebral and nonvertebral fracture risk in women with postmenopausal osteoporosis treated with once-yearly zoledronic acid 5 mg: the HORIZON-Pivotal Fracture Trial (PFT). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20120801
Health-economic review of zoledronic acid for the management of skeletal-related events in bone-metastatic prostate cancer. Expert review of pharmacoeconomics & outcomes research 20120801
A retrospective study evaluating frequency and risk factors of osteonecrosis of the jaw in 576 cancer patients receiving intravenous bisphosphonates. American journal of clinical oncology 20120801
Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter. Clinical cancer research : an official journal of the American Association for Cancer Research 20120801
Cost-effectiveness of denosumab compared with zoledronic acid in patients with breast cancer and bone metastases. Clinical breast cancer 20120801
Skeletal histomorphometry in subjects on teriparatide or zoledronic acid therapy (SHOTZ) study: a randomized controlled trial. The Journal of clinical endocrinology and metabolism 20120801
Zoledronic acid in patients with stage IIIA/B NSCLC: results of a randomized, phase III study. Annals of oncology : official journal of the European Society for Medical Oncology 20120801
[Amplification of γδ T cells in PBMCs of healthy donors and osteosarcoma patients stimulated by zoledronate]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20120801
[Management of bone metastasis originating from lung cancer]. Gan to kagaku ryoho. Cancer & chemotherapy 20120801
Effect and mechanism of zoledronate on prevention of collapse in osteonecrosis of the femoral head. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20120801
Effects of bone-targeted agents on cancer progression and mortality. Journal of the National Cancer Institute 20120718
Everolimus is an active agent in medullary thyroid cancer: a clinical and in vitro study. Journal of cellular and molecular medicine 20120701
Quality of life and health status with zoledronic acid and generic alendronate--a secondary analysis of the Rapid Onset and Sustained Efficacy (ROSE) study in postmenopausal women with low bone mass. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120701
Zoledronic acid induces S-phase arrest via a DNA damage response in normal human oral keratinocytes. Archives of oral biology 20120701
Complete remission and long-term survival in a child with relapsed medulloblastoma with extensive osteosclerotic bony metastasis with a novel metronomic chemobiological approach. Journal of pediatric hematology/oncology 20120701
Adherence with intravenous zoledronate and intravenous ibandronate in the United States Medicare population. Arthritis care & research 20120701
Time to onset of antifracture efficacy and year-by-year persistence of effect of zoledronic acid in women with osteoporosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20120701
Zoledronic acid improves bone mineral density in pediatric spinal cord injury. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20120701
Evaluation of the clinical benefit of long-term (beyond 2 years) treatment of skeletal-related events in advanced cancers with zoledronic acid. Current medical research and opinion 20120701
Interpreting results from oncology clinical trials: a comparison of denosumab to zoledronic acid for the prevention of skeletal-related events in cancer patients. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120701
Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model. Acta pharmacologica Sinica 20120701
What is the role of hyperbaric oxygen in the management of bisphosphonate-related osteonecrosis of the jaw: a randomized controlled trial of hyperbaric oxygen as an adjunct to surgery and antibiotics. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20120701
[A survey of the dosage of zoledronic acid and investigation of the relationship between renal function and adverse events]. Gan to kagaku ryoho. Cancer & chemotherapy 20120701
[Zoledronic acid incorporated in chitosan/calcium phosphate ceramic: characterization and in vitro response of osteoblast cells]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20120701
Effect of (Neo)adjuvant zoledronic acid on disease-free and overall survival in clinical stage II/III breast cancer. British journal of cancer 20120626
Effects of induction and maintenance plus long-term bisphosphonates on bone disease in patients with multiple myeloma: the Medical Research Council Myeloma IX Trial. Blood 20120607
Zoledronic acid inhibits proliferation and impairs migration and invasion through downregulating VEGF and MMPs expression in human nasopharyngeal carcinoma cells. Medical oncology (Northwood, London, England) 20120601
Small cell carcinoma of the urinary bladder with hypercalcemia. Medical oncology (Northwood, London, England) 20120601
Suppurative arthritis of the temporomandibular joint associated with bisphosphonate: a case report. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20120601
New role for an established drug? Bisphosphonates as potential anticancer agents. Prostate cancer and prostatic diseases 20120601
Combination therapy inhibits development and progression of mammary tumours in immunocompetent mice. Breast cancer research and treatment 20120601
Lip ulceration associated with intravenous administration of zoledronic acid: report of a case. Head and neck pathology 20120601
Efficacy of zoledronic acid in postmenopausal Japanese women with early breast cancer receiving adjuvant letrozole: 12-month results. Breast cancer research and treatment 20120601
Calcium phosphate cement delivering zoledronate decreases bone turnover rate and restores bone architecture in ovariectomized rats. Biomedical materials (Bristol, England) 20120601
Effects of intravenous zoledronate on bone turnover and bone density persist for at least five years in HIV-infected men. The Journal of clinical endocrinology and metabolism 20120601
Five years of anti-resorptive activity after a single dose of zoledronate--results from a randomized double-blind placebo-controlled trial. Bone 20120601
Cost-effectiveness of denosumab versus zoledronic acid in the management of skeletal metastases secondary to breast cancer. Clinical therapeutics 20120601
Use of zoledronate for treatment of a bone fragility disorder in horses. Journal of the American Veterinary Medical Association 20120601
Radical surgical treatment of bisphosphonate related osteonecrosis of the jaw. Australian dental journal 20120601
Positive effects of zoledronate on skeletal-related events in patients with renal cell cancer and bone metastases. The Canadian journal of urology 20120601
Re: Positive effects of zoledronate on skeletal-related events in patients with renal cell cancer and bone metastases. The Canadian journal of urology 20120601
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Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases. Annals of oncology : official journal of the European Society for Medical Oncology 20120501
Sensitization of human osteosarcoma cells to Vγ9Vδ2 T-cell-mediated cytotoxicity by zoledronate. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20120501
Involvement of the mevalonate pathway in the antiproliferative effect of zoledronate on ACHN renal cell carcinoma cells. Oncology reports 20120501
'Atypical femoral fractures' during bisphosphonate exposure in adult hypophosphatasia. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20120501
Acute phase response following intravenous zoledronate in postmenopausal women with low bone mass. Bone 20120501
Development of superior bone scintigraphic agent from a series of (99m)Tc-labeled zoledronic acid derivatives. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20120501
Bisphosphonate therapy in multiple myeloma in preventing vertebral collapses: preliminary report. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20120501
Cellular interactions of synovial fluid γδ T cells in juvenile idiopathic arthritis. Journal of immunology (Baltimore, Md. : 1950) 20120501
Persistency with zoledronic acid is associated with clinical benefit in patients with multiple myeloma. American journal of hematology 20120501
Zoledronic acid produces antitumor effects on mesothelioma through apoptosis and S-phase arrest in p53-independent and Ras prenylation-independent manners. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20120501
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Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid. American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 20120501
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An extensive hemimelic polyostotic fibrous dysplasia: a case report. Rheumatology international 20120401
Effects of zoledronic acid on sutural bone formation: a computed tomography study. European journal of orthodontics 20120401
Is ¹⁵³Samarium-ethylene-diamine-tetramethyl-phosphonate (EDTMP) bone uptake influenced by bisphosphonates in patients with castration-resistant prostate cancer? World journal of urology 20120401
Awareness and education of patients receiving bisphosphonates. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 20120401
The effects of combined human parathyroid hormone (1-34) and zoledronic acid treatment on fracture healing in osteoporotic rats. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120401
Possible zoledronic acid-induced dermatomyositis. Clinical and experimental dermatology 20120401
Lessons learned from an osteoporosis clinical trial in frail long-term care residents. Clinical trials (London, England) 20120401
Lower dose dexamethasone/thalidomide and zoledronic acid every 3 weeks in previously untreated multiple myeloma. Clinical lymphoma, myeloma & leukemia 20120401
The relation between zoledronic acid infusion and interbody fusion in patients undergoing transforaminal lumbar interbody fusion surgery. Acta neurochirurgica 20120401
Vitamin D reduces musculoskeletal pain after infusion of zoledronic acid for postmenopausal osteoporosis. Calcified tissue international 20120401
Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1. Journal of immunology (Baltimore, Md. : 1950) 20120401
Bisphosphonate-associated orbital inflammation--a case report and review. Orbit (Amsterdam, Netherlands) 20120401
Efficacy of vinorelbine and zoledronate combination therapy against postoperative recurrence of lung cancer. Gan to kagaku ryoho. Cancer & chemotherapy 20120401
Myeloma: diagnosis complications and supportive care. Hematology (Amsterdam, Netherlands) 20120401
Patient management, and time and health care resource utilization associated with the use of intravenous bisphosphonates for patients with metastatic bone disease: a Delphi study. Hospital practice (1995) 20120401
Bone metastasis targeting: a novel approach to reach bone using Zoledronate anchored PLGA nanoparticle as carrier system loaded with Docetaxel. Journal of controlled release : official journal of the Controlled Release Society 20120328
Regression of giant cell tumor of the cervical spine with bisphosphonate as single therapy. Spine 20120315
Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. Proceedings of the National Academy of Sciences of the United States of America 20120313
Coercing bisphosphonates to kill cancer cells with nanoscale coordination polymers. Chemical communications (Cambridge, England) 20120311
Paget's disease of bone: analysis of 134 cases from an island in Southern Brazil: another cluster of Paget's disease of bone in South America. Rheumatology international 20120301
Zoledronic acid blocks the interaction between mesenchymal stem cells and breast cancer cells: implications for adjuvant therapy of breast cancer. Annals of oncology : official journal of the European Society for Medical Oncology 20120301
Activated human γδ T cells induce peptide-specific CD8+ T-cell responses to tumor-associated self-antigens. Cancer immunology, immunotherapy : CII 20120301
Post hoc analysis of a single IV infusion of zoledronic acid versus daily oral risedronate on lumbar spine bone mineral density in different subgroups with glucocorticoid-induced osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120301
Final 5-year results of Z-FAST trial: adjuvant zoledronic acid maintains bone mass in postmenopausal breast cancer patients receiving letrozole. Cancer 20120301
Data from extension trials: denosumab and zoledronic acid. Current osteoporosis reports 20120301
Multiple myeloma vs. breast cancer patients with bisphosphonates-related osteonecrosis of the jaws: a comparative analysis of response to treatment and predictors of outcome. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20120301
[Renal insufficiency and breast cancer]. Bulletin du cancer 20120301
Femoral stress fractures associated with long-term bisphosphonate treatment. Clinical orthopaedics and related research 20120301
Krüppel-like factors KLF2 and 6 and Ki-67 are direct targets of zoledronic acid in MCF-7 cells. Bone 20120301
Denosumab for the management of bone disease in patients with solid tumors. Expert review of anticancer therapy 20120301
Osteoclasts derived from patients with neurofibromatosis 1 (NF1) display insensitivity to bisphosphonates in vitro. Bone 20120301
Prolonged hypocalcemia after zoledronic acid in a patient with metastatic prostate carcinoma: did zoledronic acid trigger osteoblastic activity and avid calcium uptake? Clinical genitourinary cancer 20120301
Clinical use of bone turnover markers to monitor pharmacologic fracture prevention therapy. Current osteoporosis reports 20120301
[Combination or sequential treatment using PTH and anti-resorption therapies]. Clinical calcium 20120301
Paget disease of bone - an update. Australian family physician 20120301
Atypical femoral shaft fracture in a patient with non-metastatic prostate cancer on zoledronic acid therapy: effect of therapy or coincidence? Singapore medical journal 20120301
Influence of bisphosphonates on the osteoblast RANKL and OPG gene expression in vitro. Clinical oral investigations 20120201
The influence of bisphosphonates on viability, migration, and apoptosis of human oral keratinocytes--in vitro study. Clinical oral investigations 20120201
Treatment with acetaminophen/paracetamol or ibuprofen alleviates post-dose symptoms related to intravenous infusion with zoledronic acid 5 mg. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120201
Rapid Onset and Sustained Efficacy (ROSE) study: results of a randomised, multicentre trial comparing the effect of zoledronic acid or alendronate on bone metabolism in postmenopausal women with low bone mass. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120201
Increases in bone turnover marker levels at an early phase after starting zoledronic acid predicts skeletal-related events in patients with prostate cancer with bone metastasis. BJU international 20120201
Bisphosphonate-related osteonecrosis of jaws in 3 osteoporotic patients with history of oral bisphosphonate use treated with single yearly zoledronic acid infusion. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20120201
Bisphosphonates and breast cancer prevention. Anti-cancer agents in medicinal chemistry 20120201
Bisphosphonate anticancer activity in prostate cancer and other genitourinary cancers. Anti-cancer agents in medicinal chemistry 20120201
Anticancer activity of bisphosphonates in breast cancer. Anti-cancer agents in medicinal chemistry 20120201
Bisphosphonates in lung cancer: can they provide benefits beyond prevention of skeletal morbidity? Anti-cancer agents in medicinal chemistry 20120201
Immediate Administration of Zoledronic Acid Reduces Aromatase Inhibitor-Associated Bone Loss in Postmenopausal Women With Early Breast Cancer: 12-month analysis of the E-ZO-FAST trial. Clinical breast cancer 20120201
Gamma delta T cells from HIV+ donors can be expanded in vitro by zoledronate/interleukin-2 to become cytotoxic effectors for antibody-dependent cellular cytotoxicity. Cytotherapy 20120201
Zoledronic acid in the treatment of early-stage breast cancer: is there a final verdict? Current oncology reports 20120201
Additive effect of zoledronic acid on serum prostate-specific antigen changes for hormone-sensitive prostate cancer patients with bone metastasis treated by combined androgen blockade. International journal of urology : official journal of the Japanese Urological Association 20120201
The Medical Research Council Myeloma IX Trial: new clinical insights on the anticancer effects of zoledronic acid in patients with multiple myeloma. Clinical lymphoma, myeloma & leukemia 20120201
The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis: a randomized extension to the HORIZON-Pivotal Fracture Trial (PFT). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20120201
Histopathological features of osteonecrosis of the jaw associated with bisphosphonates. Histopathology 20120201
Bisphosphonate therapy for osteoporosis: the long and short of it. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20120201
[Multiple myeloma]. [Rinsho ketsueki] The Japanese journal of clinical hematology 20120201
Atypical insufficiency type femoral stress fractures in patient on bisphosphonates. Medicine and health, Rhode Island 20120201
MMP-9 from sublethally irradiated tumor promotes Lewis lung carcinoma cell invasiveness and pulmonary metastasis. Oncogene 20120126
Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia. Blood 20120112
Risk of renal failure in cancer patients with bone metastasis treated with renally adjusted zoledronic acid. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120101
Predictors of new and severe vertebral fractures: results from the HORIZON Pivotal Fracture Trial. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120101
New self-assembly nanoparticles and stealth liposomes for the delivery of zoledronic acid: a comparative study. Biotechnology advances 20120101
Zoledronate and pamidronate depress neutrophil functions and survival in mice. British journal of pharmacology 20120101
Number needed to treat is incorrect without proper time-related considerations. Journal of clinical epidemiology 20120101
Complete clinical and biological response to zoledronic acid in castrate-resistant prostate cancer metastatic to bone. Anti-cancer drugs 20120101
Association of laser phototherapy with PRP improves healing of bisphosphonate-related osteonecrosis of the jaws in cancer patients: a preliminary study. Oral oncology 20120101
Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer. Cancer science 20120101
The Medical Research Council Myeloma IX trial: the impact on treatment paradigms. European journal of haematology 20120101
Prophylactic use of zoledronic acid to prevent early bone loss is safe and feasible in patients with acute myeloid leukemia undergoing allogeneic stem cell transplantation. Clinical transplantation 20120101
The effect of zoledronate-hydroxyapatite nanocomposites on osteoclasts and osteoblast-like cells in vitro. Biomaterials 20120101
Retrospective database analysis of the effect of zoledronic acid on skeletal-related events and mortality in women with breast cancer and bone metastasis in a managed care plan. Journal of medical economics 20120101
Effect of zoledronate acid treatment on osseointegration and fixation of implants in autologous iliac bone grafts in ovariectomized rabbits. Bone 20120101
Bisphosphonates and glucocorticoid osteoporosis in men: results of a randomized controlled trial comparing zoledronic acid with risedronate. Bone 20120101
Low-dose zoledronate in osteopenic postmenopausal women: a randomized controlled trial. The Journal of clinical endocrinology and metabolism 20120101
Skeletal remodeling following clinically relevant radiation-induced bone damage treated with zoledronic acid. Calcified tissue international 20120101
The efficacy of zoledronic acid in breast cancer adjuvant therapy: a meta-analysis of randomised controlled trials. European journal of cancer (Oxford, England : 1990) 20120101
Increased numbers of nonattached osteoclasts after long-term zoledronic acid therapy in mice. Endocrinology 20120101
Assessment of zoledronic acid treatment patterns and clinical outcomes in patients with bone metastases from genitourinary cancers. Journal of medical economics 20120101
Retrospective evaluation of the clinical benefit of long-term continuous use of zoledronic acid in patients with lung cancer and bone metastases. Journal of medical economics 20120101
Tumor-promoting versus tumor-antagonizing roles of γδ T cells in cancer immunotherapy: results from a prospective phase I/II trial. Journal of immunotherapy (Hagerstown, Md. : 1997) 20120101
Cost-effectiveness of zoledronic acid vs clodronic acid for newly-diagnosed multiple myeloma from the United Kingdom healthcare system perspective. Journal of medical economics 20120101
Site specific effects of zoledronic acid during tibial and mandibular fracture repair. PloS one 20120101
Cost-effectiveness of denosumab vs zoledronic acid for prevention of skeletal-related events in patients with solid tumors and bone metastases in the United States. Journal of medical economics 20120101
Effect of local zoledronate on implant osseointegration in a rat model. BMC musculoskeletal disorders 20120101
Platelet-rich plasma improves wound healing in multiple myeloma bisphosphonate-associated osteonecrosis of the jaw patients. Journal of biological regulators and homeostatic agents 20120101
Early appearance of osteonecrosis of the jaw after zoledronic acid in a patient with a long history of taking oral bisphosphonates. BMJ case reports 20120101
Activation of BK(Ca) channels in zoledronic acid-induced apoptosis of MDA-MB-231 breast cancer cells. PloS one 20120101
Antitumor activity of zoledronic acid in primary breast cancer cells determined by the ATP tumor chemosensitivity assay. BMC cancer 20120101
Treatment of osteonecrosis of the jaw (ONJ) by medical ozone gas insufflation. A case report. Tumori 20120101
Zoledronic acid as an adjuvant therapy in patients with breast cancer: a systematic review and meta-analysis. PloS one 20120101
Zoledronate inhibits ischemia-induced neovascularization by impairing the mobilization and function of endothelial progenitor cells. PloS one 20120101
Safety and efficacy of a 1-year treatment with zoledronic acid compared with pamidronate in children with osteogenesis imperfecta. Journal of pediatric endocrinology & metabolism : JPEM 20120101
Normal bone turnover markers in a patient with active Paget's disease of bone: response to treatment with zoledronic acid. Endokrynologia Polska 20120101
Management of bone metastases in refractory prostate cancer--role of denosumab. Clinical interventions in aging 20120101
Zoledronate attenuates angiogenic effects of angiotensin II-stimulated endothelial progenitor cells via RhoA and MAPK signaling. PloS one 20120101
Short-term effects of zoledronate on the histomorphology of osteoclast in young albino rats. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 20111220
Cost-effectiveness of zoledronic acid in the prevention of skeletal-related events in patients with bone metastases secondary to advanced renal cell carcinoma: application to France, Germany, and the United Kingdom. The European journal of health economics : HEPAC : health economics in prevention and care 20111201
Zoledronate, ibandronate and clodronate enhance osteoblast differentiation in a dose dependent manner--a quantitative in vitro gene expression analysis of Dlx5, Runx2, OCN, MSX1 and MSX2. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 20111201
Management of aromatase inhibitor-associated bone loss in postmenopausal women with breast cancer: practical guidance for prevention and treatment. Annals of oncology : official journal of the European Society for Medical Oncology 20111201
Nanotechnologies to use bisphosphonates as potent anticancer agents: the effects of zoledronic acid encapsulated into liposomes. Nanomedicine : nanotechnology, biology, and medicine 20111201
In vivo assessment of local effects after application of bone screws delivering bisphosphonates into a compromised cancellous bone site. Clinical biomechanics (Bristol, Avon) 20111201
Effects of zoledronic acid on bone mineral density during aromatase inhibitor treatment of Korean postmenopausal breast cancer patients. Breast cancer research and treatment 20111201
Anti-osteoporotic drug release from ordered mesoporous bioceramics: experiments and modeling. AAPS PharmSciTech 20111201
Pilot trial of bone-targeted therapy combining zoledronate with fluvastatin or atorvastatin for patients with metastatic renal cell carcinoma. Clinical genitourinary cancer 20111201
A prospective clinical trial for assessing the efficacy of a minimally invasive protocol in patients with bisphosphonate-associated osteonecrosis of the jaws. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20111201
Zoledronic acid modulates maturation of human monocyte-derived dendritic cells. Experimental biology and medicine (Maywood, N.J.) 20111201
Preventive effects of zoledronic acid on bone metastasis in mice injected with human breast cancer cells. Journal of Korean medical science 20111201
[Factors associated with acute febrile reaction in elderly patients receiving intravenous zoledronic acid for osteoporosis]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20111201
AZURE subgroup analysis shows adjuvant therapy with zoledronic acid may benefit breast cancer patients postmenopausal >5 years. Oncology (Williston Park, N.Y.) 20111115
Modern management of malignant hypercalcemia. The American journal of hospice & palliative care 20111101
Zoledronic acid inhibits macrophage SOCS3 expression and enhances cytokine production. Journal of cellular biochemistry 20111101
Matrix metalloproteinase-9 expression in alveolar extraction sockets of Zoledronic acid-treated rats. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20111101
Bisphosphonate-related osteonecrosis: laser-assisted surgical treatment or conventional surgery? Lasers in medical science 20111101
Zoledronic acid improves bone mineral density, reduces bone turnover and improves skeletal architecture over 2 years of treatment in children with secondary osteoporosis. Bone 20111101
A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro. Journal of lipid research 20111101
In vitro generation of mature human osteoclasts. Calcified tissue international 20111101
Economic evaluation of clodronate and zoledronate in patients diagnosed with metastatic bone disease from the perspective of public and third party payors in Brazil. Clinical therapeutics 20111101
Antiangiogenic effects of zoledronate on cancer neovasculature. Future oncology (London, England) 20111101
[A very elderly case of advanced gastric cancer with disseminated carcinomatosis of bone marrow and multiple bone metastasis, diagnosed by extremely elevated serum alkaline phosphatase levels, and treated with low-dose S-1 to avoid disseminated intravascular coagulation]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20111101
Once-yearly zoledronic acid in older men compared with women with recent hip fracture. Journal of the American Geriatrics Society 20111101
The case of the overlooked osteoclasts. ONS connect 20111101
Ask the doctor. I'm looking for information on Prolia and Reclast as alternatives to Boniva. Harvard women's health watch 20111101
Breast-cancer adjuvant therapy with zoledronic acid. The New England journal of medicine 20111013
Treatment of hypertrophic osteoarthropathy with zoledronic acid: case report and review of the literature. Seminars in arthritis and rheumatism 20111001
Pilot trial of interleukin-2 and zoledronic acid to augment γδ T cells as treatment for patients with refractory renal cell carcinoma. Cancer immunology, immunotherapy : CII 20111001
Impact of oncopediatric dosing regimen of zoledronic acid on bone growth: preclinical studies and case report of an osteosarcoma pediatric patient. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20111001
Manipulation of the anabolic and catabolic responses with BMP-2 and zoledronic acid in a rat femoral fracture model. Bone 20111001
Novel therapy to reverse the cellular effects of bisphosphonates on primary human oral fibroblasts. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20111001
Zoledronic acid combined with chemotherapy bring survival benefits to patients with bone metastases from nasopharyngeal carcinoma. Journal of cancer research and clinical oncology 20111001
New perspectives on zoledronic acid in breast cancer: potential augmentation of anticancer immune response. Cancer investigation 20111001
Economic evaluation of denosumab compared with zoledronic acid in hormone-refractory prostate cancer patients with bone metastases. Journal of managed care pharmacy : JMCP 20111001
[Inflammation of the jaws during treatment with bisphosphonates]. Deutsche medizinische Wochenschrift (1946) 20111001
DC-like cell-dependent activation of human natural killer cells by the bisphosphonate zoledronic acid is regulated by γδ T lymphocytes. Blood 20110908
Zoledronate activates NK cells. Blood 20110908
Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumours. British journal of cancer 20110906
Parenteral bisphosphonates for osteoporosis in patients with primary biliary cirrhosis. American journal of therapeutics 20110901
Cytotoxic effect of clodronate and zoledronate on the chondrosarcoma cell lines HTB-94 and CAL-78. International orthopaedics 20110901
Oral bisphosphonates are associated with reduced mortality in frail older people: a prospective five-year study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110901
Zoledronic acid results in better health-related quality of life following hip fracture: the HORIZON-Recurrent Fracture Trial. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110901
A community-based clinical trial of Intra-Venous zOledRonic acid once Yearly in comparison to oral bisphosphonates in postmenopausal women with osteoporosis: the IVORY trial Methodological considerations. Contemporary clinical trials 20110901
A single infusion of zoledronic acid produces sustained remissions in Paget disease: data to 6.5 years. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20110901
Antitumor effects of bisphosphonates: from the laboratory to the clinic. Current opinion in supportive and palliative care 20110901
Denosumab: benefits of RANK ligand inhibition in cancer patients. Current opinion in supportive and palliative care 20110901
Bisphosphonate-associated osteonecrosis of the jaw: a six-year history of a case. The New Zealand dental journal 20110901
[Inhibitory effects of zoledronic acid on cell proliferation and invasion in human nasopharyngeal carcinoma cell line HNE1]. Zhonghua yi xue za zhi 20110830
Further analyses of the Myeloma IX Study. Lancet (London, England) 20110827
Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid. The Journal of biological chemistry 20110819
Immune modulation by zoledronic acid in human myeloma: an advantageous cross-talk between Vγ9Vδ2 T cells, αβ CD8+ T cells, regulatory T cells, and dendritic cells. Journal of immunology (Baltimore, Md. : 1950) 20110815
Dosing of zoledronic acid throughout the treatment continuum in breast cancer. Critical reviews in oncology/hematology 20110801
Effect of acetaminophen and fluvastatin on post-dose symptoms following infusion of zoledronic acid. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110801
Association between timing of zoledronic acid infusion and hip fracture healing. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110801
A peroxisome proliferator-activated receptor gamma (PPARG) polymorphism is associated with zoledronic acid-related osteonecrosis of the jaw in multiple myeloma patients: analysis by DMET microarray profiling. British journal of haematology 20110801
Phase I/II study of adoptive transfer of γδ T cells in combination with zoledronic acid and IL-2 to patients with advanced renal cell carcinoma. Cancer immunology, immunotherapy : CII 20110801
Osteonecrosis of the jaw in oncology patients treated with bisphosphonates: prospective experience of a dental oncology referral center. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20110801
Differential impairment of vascularization and angiogenesis in bisphosphonate-associated osteonecrosis of the jaw-related mucoperiosteal tissue. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20110801
A phase I study of zoledronic acid and low-dose cyclophosphamide in recurrent/refractory neuroblastoma: a new approaches to neuroblastoma therapy (NANT) study. Pediatric blood & cancer 20110801
A single bisphosphonate infusion does not accelerate fracture healing in high tibial osteotomies. Acta orthopaedica 20110801
Comparison of skeletal complications and treatment patterns associated with early vs. delayed zoledronic acid therapy in multiple myeloma. Clinical lymphoma, myeloma & leukemia 20110801
Osteonecrosis of the jaw: dental outcomes in metastatic breast cancer patients treated with bisphosphonates with/without bevacizumab. Clinical breast cancer 20110801
Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonate. The Journal of bone and joint surgery. British volume 20110801
Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised controlled trial. The Lancet. Oncology 20110801
Zoledronic acid for all patients with newly diagnosed multiple myeloma? The Lancet. Oncology 20110801
Pharmacist-run zoledronic acid clinic. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110801
Bone health medications: research questions versus clinical choices. Menopause (New York, N.Y.) 20110801
Effect of zoledronic acid compared with raloxifene on bone turnover markers in postmenopausal women with low bone density. Menopause (New York, N.Y.) 20110801
Subtrochanteric fracture in a patient receiving zoledronic acid therapy for metastatic breast cancer. Nagoya journal of medical science 20110801
Teriparitide update. Rheumatic diseases clinics of North America 20110801
Determination of zoledronic acid in human urine and blood plasma using liquid chromatography/electrospray mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110715
Locally administered zoledronic Acid therapy for giant cell tumor of bone. Orthopedics 20110707
Fluvastatin does not prevent the acute-phase response to intravenous zoledronic acid in post-menopausal women. Bone 20110701
Vascular endothelial growth factor genetic polymorphisms and haplotypes in female patients with bisphosphonate-related osteonecrosis of the jaws. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20110701
Osteoclast activity modulates B-cell development in the bone marrow. Cell research 20110701
Seizures associated with zoledronic acid for osteoporosis. The Journal of clinical endocrinology and metabolism 20110701
New developments for treatment and prevention of bone metastases. Current opinion in oncology 20110701
Bisphosphonates inhibit expression of p63 by oral keratinocytes. Journal of dental research 20110701
Pharmacokinetic evaluation of zoledronic acid. Expert opinion on drug metabolism & toxicology 20110701
The effect of zoledronic acid on the clinical resolution of Charcot neuroarthropathy: a pilot randomized controlled trial. Diabetes care 20110701
Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial. The Lancet. Oncology 20110701
High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo. Cancer research 20110701
Ras inhibition and the survival benefit favoring zoledronic acid compared with denosumab in patients with multiple myeloma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110701
Under usage of zoledronic acid in non-small cell lung cancer patients with metastatic bone disease--a short communication. European journal of cancer (Oxford, England : 1990) 20110701
Rubber dam clamp trauma, root canal therapy, and osteonecrosis of the jaw. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20110701
Targeting myeloma-osteoclast interaction with Vγ9Vδ2 T cells. International journal of hematology 20110701
Preparation and in vivo biological investigations on a novel radioligand for bone scanning: technetium-99m-labeled zoledronic acid derivative. Nuclear medicine and biology 20110701
Effects of bisphosphonates on sutural bone formation and relapse: A histologic and immunohistochemical study. American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 20110701
Combinatorial strategies for alleviation of tumor-associated immune suppression and therapeutic vaccination against ovarian cancer. Immunotherapy 20110701
Zoledronic acid: multiplicity of use across the cancer continuum. Expert review of anticancer therapy 20110701
[Therapy for malignancies and inflammatory disorders by modulating human dendritic cell functions]. [Rinsho ketsueki] The Japanese journal of clinical hematology 20110701
Induction of cytotoxic T lymphocytes by CEA peptide-pulsed γδ T-cells isolated from patients with advanced cancer. Anticancer research 20110701
[Effects of local application of zoledronic acid on bone healing of tooth extraction in rats]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 20110701
Safety and efficacy of zoledronic acid in multiple myeloma. Lancet (London, England) 20110625
Safety and efficacy of zoledronic acid in multiple myeloma. Lancet (London, England) 20110625
Osteonecrosis of the jaw after zoledronic acid and denosumab treatment. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110610
Zoledronic acid and clodronate in the treatment of malignant bone metastases with hypercalcaemia; efficacy and safety comparative study. Medical oncology (Northwood, London, England) 20110601
The influence of zoledronic acid and cyclophosphamide on microcirculation regeneration in healing oral mucosal flaps. Archives of oral biology 20110601
Managing bone health with zoledronic acid: a review of randomized clinical study results. Climacteric : the journal of the International Menopause Society 20110601
Rubber dam clamp trauma during endodontic treatment: a risk factor of bisphosphonate-related osteonecrosis of the jaw? Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20110601
Effects of intravenous zoledronic acid and oral ibandronate on early changes in markers of bone turnover in patients with bone metastases from non-small cell lung cancer. International journal of clinical oncology 20110601
Effects of zoledronic acid on healing of mandibular fractures: an experimental study in rabbits. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20110601
Preventive protocol for tooth extractions in patients treated with zoledronate: a case series. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20110601
Zoledronic acid does not reduce MRI erosive progression in PsA but may suppress bone oedema: the Zoledronic Acid in Psoriatic Arthritis (ZAPA) Study. Annals of the rheumatic diseases 20110601
Expression profile of WNT molecules in prostate cancer and its regulation by aminobisphosphonates. Journal of cellular biochemistry 20110601
Safety of zoledronic acid and incidence of osteonecrosis of the jaw (ONJ) during adjuvant therapy in a randomised phase III trial (AZURE: BIG 01-04) for women with stage II/III breast cancer. Breast cancer research and treatment 20110601
Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw. International journal of oral and maxillofacial surgery 20110601
Drugs which inhibit osteoclast function suppress tumor growth through calcium reduction in bone. Bone 20110601
A phase I/IIa clinical trial of immunotherapy for elderly patients with acute myeloid leukaemia using dendritic cells co-pulsed with WT1 peptide and zoledronate. British journal of haematology 20110601
Treatment of Langerhans cell histiocytosis bone lesions with zoledronic acid: a case series. International journal of hematology 20110601
Intravenous bisphosphonates for post-menopausal osteoporosis: adherence to a network guideline. Journal of clinical pharmacy and therapeutics 20110601
Zoledronic acid to prevent bone loss in Chinese men receiving androgen deprivation therapy for prostate cancer. Asia-Pacific journal of clinical oncology 20110601
The effects of zoledronic acid and hyperbaric oxygen on posterior lumbar fusion in a rabbit model. The Journal of bone and joint surgery. British volume 20110601
Atypical fractures of the femur and ulna and complications of fracture healing in a 76-year-old woman with Sjögren's syndrome. Journal of musculoskeletal & neuronal interactions 20110601
Treatment persistence with monthly zoledronic acid is associated with lower risk and frequency of skeletal complications in patients with breast cancer and bone metastasis. Clinical breast cancer 20110601
[A case of recurrent endometrial cancer metastasis successfully treated with zoledronic Acid]. Gan to kagaku ryoho. Cancer & chemotherapy 20110601
[A case of prostate cancer with disseminated carcinomatosis of bone marrow which responded to Zoledronic acid]. Hinyokika kiyo. Acta urologica Japonica 20110601
Bisphosphonate-associated osteonecrosis of the jaws -- report of three cases in Bulgaria and review of the literature. Acta clinica Croatica 20110601
Prostate cancer: targeted therapy for prostate cancer metastases to bone. Nature reviews. Urology 20110517
Denosumab for bone metastases from breast cancer: a new therapy option? Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110510
The effects of intravenous zoledronic acid in Chinese women with postmenopausal osteoporosis. Journal of bone and mineral metabolism 20110501
Bisphosphonate effects on the behaviour of oral epithelial cells and oral fibroblasts. Archives of oral biology 20110501
Effect of zoledronic acid on bone healing subsequent to mini-implant insertion. The Angle orthodontist 20110501
No effect of rosuvastatin in the zoledronate-induced acute-phase response. Calcified tissue international 20110501
IL-23R and TCR signaling drives the generation of neonatal Vgamma9Vdelta2 T cells expressing high levels of cytotoxic mediators and producing IFN-gamma and IL-17. Journal of leukocyte biology 20110501
Clinical risk factors for recurrent fracture after hip fracture: a prospective study. Calcified tissue international 20110501
Bisphosphonates induce autophagy by depleting geranylgeranyl diphosphate. The Journal of pharmacology and experimental therapeutics 20110501
Msx-1 is suppressed in bisphosphonate-exposed jaw bone analysis of bone turnover-related cell signalling after bisphosphonate treatment. Oral diseases 20110501
Crescentic glomerulonephritis associated with vascular endothelial growth factor (VEGF) inhibitor and bisphosphonate administration. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110501
CCN1, a candidate target for zoledronic acid treatment in breast cancer. Molecular cancer therapeutics 20110501
Cisplatin as an active treatment in zoledronate-refractory hypercalcemia. Annals of oncology : official journal of the European Society for Medical Oncology 20110501
Effect of zoledronic acid on acro-osteolysis and osteoporosis in a patient with Hajdu-Cheney syndrome. Yonsei medical journal 20110501
The role of bisphosphonates in multiple myeloma: mechanisms, side effects, and the future. The oncologist 20110501
Osteonecrosis of the jaw in patients with cancer who received zoledronic acid and bevacizumab. Journal of the American Dental Association (1939) 20110501
Once-yearly zoledronic acid and days of disability, bed rest, and back pain: randomized, controlled HORIZON Pivotal Fracture Trial. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20110501
[A successful case treated with S-1 and zoledronic acid for multiple bone metastasis of breast cancer]. Gan to kagaku ryoho. Cancer & chemotherapy 20110501
Isoprenoid biosynthetic pathway inhibition disrupts monoclonal protein secretion and induces the unfolded protein response pathway in multiple myeloma cells. Leukemia research 20110401
In vivo effects of zoledronic acid on oral mucosal epithelial cells. Oral diseases 20110401
Multicompartment vectors as novel drug delivery systems: selective activation of Tγδ lymphocytes after zoledronic acid delivery. Nanomedicine : nanotechnology, biology, and medicine 20110401
Bone turnover markers as predictors of mortality risk in prostate cancer patients with bone metastases following treatment with zoledronic acid. European urology 20110401
Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS. Biochimica et biophysica acta 20110401
Zoledronic acid, a third-generation bisphosphonate, inhibits cellular growth and induces apoptosis in oral carcinoma cell lines. Oncology reports 20110401
Changes of bone resorption marker (NTX) in chemotherapy plus zoledronic acid versus chemotherapy alone for nasopharyngeal cancer patients with bone metastases. European journal of cancer (Oxford, England : 1990) 20110401
The use of zoledronic acid in pediatric cancer patients. Pediatric blood & cancer 20110401
Zoledronic acid induces autophagic cell death in human prostate cancer cells. The Journal of urology 20110401
Effect of zoledronic acid and amputation on bone invasion and lung metastasis of canine osteosarcoma in nude mice. Clinical & experimental metastasis 20110401
Zoledronic acid for prevention and treatment of osteoporosis. Expert opinion on pharmacotherapy 20110401
A single dose of intravenous zoledronate prevents glucocorticoid therapy-associated bone loss in acute flare of Crohn's disease, a randomized controlled trial. The American journal of gastroenterology 20110401
Anti-tumour and anti-angiogenetic effects of zoledronic acid on human non-small-cell lung cancer cell line. Cell proliferation 20110401
Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density: a bone chamber study in rats. Acta orthopaedica 20110401
Trials define anti-tumor effects of anti-resorptive agents: denosumab ahead of zoledronate 2 to 1. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20110401
Pamidronate and zoledronate effects in the increment of bone mineral density and histomorphometry in rats. Acta cirurgica brasileira 20110401
Osteonecrosis of the jaw. Journal of the American Dental Association (1939) 20110401
More about osteonecrosis. Journal of the American Dental Association (1939) 20110401
[Effects of zoledronic acid in the treatment of breast cancer]. Zhonghua zhong liu za zhi [Chinese journal of oncology] 20110401
Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110320
American Society of Clinical Oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110320
Effect of zoledronate on oral wound healing in rats. Clinical cancer research : an official journal of the American Association for Cancer Research 20110315
Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study. Lancet (London, England) 20110305
Unravelling the role of denosumab in prostate cancer. Lancet (London, England) 20110305
The kinetochore protein Cenp-F is a potential novel target for zoledronic acid in breast cancer cells. Journal of cellular and molecular medicine 20110301
Zoledronic acid and atrial fibrillation in cancer patients. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110301
The BH3-mimetic ABT-737 targets the apoptotic machinery in cholangiocarcinoma cell lines resulting in synergistic interactions with zoledronic acid. Cancer chemotherapy and pharmacology 20110301
Bisphosphonates affect migration ability and cell viability of HUVEC, fibroblasts and osteoblasts in vitro. Oral diseases 20110301
Effects of intravenous zoledronic acid plus subcutaneous teriparatide [rhPTH(1-34)] in postmenopausal osteoporosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20110301
Effects of estrogen deficiency and bisphosphonate therapy on osteocyte viability and microdamage accumulation in an ovine model of osteoporosis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20110301
Bisphosphonate-related osteonecrosis of the maxilla and sinusitis maxillaris. International journal of oral and maxillofacial surgery 20110301
The benefits of timely intervention with zoledronic acid in patients with metastatic prostate cancer to bones: a retrospective study of the US Veterans Affairs population. Prostate cancer and prostatic diseases 20110301
Zoledronic acid inhibits RANK expression and migration of osteoclast precursors during osteoclastogenesis. Naunyn-Schmiedeberg's archives of pharmacology 20110301
The effects of zoledronic acid on neointimal hyperplasia: a rabbit carotid anastomosis model. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20110301
Surgery-triggered and non surgery-triggered Bisphosphonate-related Osteonecrosis of the Jaws (BRONJ): A retrospective analysis of 567 cases in an Italian multicenter study. Oral oncology 20110301
Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expanded γδTcells: a phase I clinical study. Journal of immunotherapy (Hagerstown, Md. : 1997) 20110301
Zoledronic acid preserves bone mineral density in premenopausal women who develop ovarian failure due to adjuvant chemotherapy: final results from CALGB trial 79809. European journal of cancer (Oxford, England : 1990) 20110301
Breast cancer bone metastases: denosumab or zoledronic acid? Nature reviews. Endocrinology 20110301
[Parathyroid crisis due to a cystic parathyroid adenoma]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20110301
[Encounter of cancer cells with bone. Treatment of bone metastases from breast cancer]. Clinical calcium 20110301
[Encounter of cancer cells with bone. Management of bone metastasis arising from prostate cancer]. Clinical calcium 20110301
Multiple hydrogen bonds in cytosinium zoledronate trihydrate. Acta crystallographica. Section C, Crystal structure communications 20110301
[A case of castration-refractory prostate cancer showing marked decrease of serum PSA level after zoledronic acid treatment with estramustine phosphate and prednisolone]. Gan to kagaku ryoho. Cancer & chemotherapy 20110301
Unexpected AZURE results lead to rethink for Zometa(®). Expert review of anticancer therapy 20110301
Zoledronic acid for adjuvant use in patients with breast cancer. Expert review of anticancer therapy 20110301
Direct antitumour activity of zoledronic acid: preclinical and clinical data. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20110301
Cost-effectiveness of zoledronic acid in the management of skeletal metastases in patients with lung cancer in France, Germany, Portugal, the Netherlands, and the United kingdom. Clinical therapeutics 20110301
Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy. Hiroshima journal of medical sciences 20110301
'Disappointing' trial results offer hope for older women with breast cancer. JAMA 20110223
The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis. Journal of biomechanics 20110203
Osteonecrosis of the jaw and the role of macrophages. Journal of the National Cancer Institute 20110202
Bisphosphonates: restrictions for vasculogenesis and angiogenesis: inhibition of cell function of endothelial progenitor cells and mature endothelial cells in vitro. Clinical oral investigations 20110201
Intravenous zoledronic acid and oral alendronate in patients with a low trauma fracture: experience from an osteoporosis clinic. Internal medicine journal 20110201
Compromised osseous healing of dental extraction sites in zoledronic acid-treated dogs. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110201
Bisphosphonate remains highly localized after elution from porous implants. Clinical orthopaedics and related research 20110201
Association between bisphosphonates and jaw osteonecrosis: a study in Wistar rats. Head & neck 20110201
Investigation of alendronate-doped apatitic cements as a potential technology for the prevention of osteoporotic hip fractures: critical influence of the drug introduction mode on the in vitro cement properties. Acta biomaterialia 20110201
Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase. Bone 20110201
Effects of short-term zoledronic acid treatment on bone remodeling and healing at surgical sites in the maxilla and mandible of aged dogs. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20110201
Zoledronate inhibits intimal hyperplasia in balloon-injured rat carotid artery. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20110201
Expression and function of PD-1 in human γδ T cells that recognize phosphoantigens. European journal of immunology 20110201
Development of multiple myeloma in a case of longstanding ankylosing spondylitis: more than a coincidence? International journal of rheumatic diseases 20110201
Gorham-Stout syndrome of the pelvic girdle treated by radiation therapy: a case report. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20110201
Zoledronic acid: a framework of emerging anticancer evidence throughout the cancer continuum. Critical reviews in oncology/hematology 20110201
Established role of bisphosphonate therapy for prevention of skeletal complications from myeloma bone disease. Critical reviews in oncology/hematology 20110201
Can bisphosphonates improve outcomes in patients with newly diagnosed multiple myeloma? Critical reviews in oncology/hematology 20110201
The backbone of progress--preclinical studies and innovations with zoledronic acid. Critical reviews in oncology/hematology 20110201
Anticancer evidence for zoledronic acid across the cancer continuum. Critical reviews in oncology/hematology 20110201
[Study on the effects of zoledronic-acid-loaded collagen membrane on bone metabolism cells]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 20110201
Self-assembly nanoparticles for the delivery of bisphosphonates into tumors. International journal of pharmaceutics 20110117
Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases. International journal of cancer 20110115
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Early treatment with zoledronic acid prevents bone loss at the hip following acute spinal cord injury. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110101
Zoledronic acid-induced transient hepatotoxicity in a patient effectively treated for Paget's disease of bone. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110101
Initial results of the treatment of diffuse sclerosing osteomyelitis of the mandible with bisphosphonates. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 20110101
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Estimating minimally important differences for the worst pain rating of the Brief Pain Inventory-Short Form. The journal of supportive oncology 20110101
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Transient changes in thyroid functions tests after zoledronic acid infusion. Endocrine journal 20110101
Systemic lupus erythematosus and hypercalcaemia: case report and brief review of the literature. Scandinavian journal of rheumatology 20110101
Expansion of human peripheral blood γδ T cells using zoledronate. Journal of visualized experiments : JoVE 20110101
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Going on a drug holiday? Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 20110101
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A feasibility study of zoledronic acid combined with carboplatin/nedaplatin plus paclitaxel in patients with non-small cell lung cancer with bone metastases. Tumori 20110101
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Recurrent scrotal hemangiomas during treatment with sunitinib. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20101210
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First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. Lancet (London, England) 20101202
Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. Journal of cellular and molecular medicine 20101201
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The effects of topical application of bisphosphonates on replanted rat molars. Dental traumatology : official publication of International Association for Dental Traumatology 20101201
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Effects of high dose of zoledronic acid on superficial vascular network of membranous bone sites: an intravital study on rat calvarium. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20101101
Beyond bisphosphonates: photodynamic therapy structurally augments metastatically involved vertebrae and destroys tumor tissue. Breast cancer research and treatment 20101101
Efficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36-month results of the ZO-FAST Study. Annals of oncology : official journal of the European Society for Medical Oncology 20101101
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Surface immobilized zoledronate improves screw fixation in rat bone: a new method for the coating of metal implants. Journal of materials science. Materials in medicine 20101101
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Zoledronic acid reduces bone loss and tumor growth in an orthotopic xenograft model of osteolytic oral squamous cell carcinoma. Cancer research 20101101
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Zoledronic Acid improves clinical outcomes when administered before onset of bone pain in patients with prostate cancer. Urology 20101101
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Targeting the {alpha} receptor for platelet-derived growth factor as a primary or combination therapy in a preclinical model of prostate cancer skeletal metastasis. Clinical cancer research : an official journal of the American Association for Cancer Research 20101015
A single dose of zoledronic acid reverses the deleterious effects of glucocorticoids on titanium implant osseointegration. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20101001
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Zoledronic acid for the treatment of osteopenia in pediatric Crohn's disease. Pediatrics international : official journal of the Japan Pediatric Society 20101001
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Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice. Calcified tissue international 20101001
Prognostic factors for skeletal complications from metastatic bone disease in breast cancer. Breast cancer research and treatment 20101001
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Effect of withdrawal of zoledronic acid treatment on bone remodelling markers in multiple myeloma. British journal of haematology 20101001
Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease. Osteoarthritis and cartilage 20101001
Predicting skeletal complications in metastatic breast cancer raises challenges. Breast cancer research and treatment 20101001
Short-term zoledronic acid reduces trabecular bone remodeling in dogs. European journal of oral sciences 20101001
Zoledronic acid as a new adjuvant therapeutic strategy for Ewing's sarcoma patients. Cancer research 20101001
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Zolendronate associated inflammatory orbital disease. The New Zealand medical journal 20100924
Metronomic administration of zoledronic acid and taxotere combination in castration resistant prostate cancer patients: phase I ZANTE trial. Cancer biology & therapy 20100915
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Respiratory complications associated with IV zoledronic acid infusion in the treatment of postmenopausal osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100901
Flare-up of hand osteoarthritis caused by zoledronic acid infusion. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100901
Urinary N-telopeptide (uNTx) is an independent prognostic factor for overall survival in patients with bone metastases from castration-resistant prostate cancer. Annals of oncology : official journal of the European Society for Medical Oncology 20100901
Preparation and preclinical pharmacological study on a novel bone imaging agent (99m)Tc-EMIDP. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20100901
Bone-marker levels in patients with prostate cancer: potential correlations with outcomes. Current opinion in supportive and palliative care 20100901
Synergistic induction of bone formation by hOP-1, hTGF-beta3 and inhibition by zoledronate in macroporous coral-derived hydroxyapatites. Biomaterials 20100901
Coculturing dendritic cells with zoledronate acid efficiently enhance the anti-tumor effects of cytokine-induced killer cells. Journal of clinical immunology 20100901
Bisphosphonate protonation states, conformations, and dynamics on bone mineral probed by solid-state NMR without isotope enrichment. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20100901
Characterization of and risk factors for the acute-phase response after zoledronic acid. The Journal of clinical endocrinology and metabolism 20100901
Update on the use of zoledronic acid in the management of osteoporosis. Current osteoporosis reports 20100901
Anabolic and antiresorptive drugs improve trabecular microarchitecture and reduce fracture risk following radiation therapy. Calcified tissue international 20100901
Updates on osteonecrosis of the jaw. Current opinion in supportive and palliative care 20100901
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A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro. Cancer letters 20100828
Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma. British journal of cancer 20100824
Delivery of zoledronic acid encapsulated in folate-targeted liposome results in potent in vitro cytotoxic activity on tumor cells. Journal of controlled release : official journal of the Controlled Release Society 20100817
Detecting early bone changes using in vivo micro-CT in ovariectomized, zoledronic acid-treated, and sham-operated rats. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100801
A single pretreatment by zoledronic acid converts metastases from osteolytic to osteoblastic in the rat. Microscopy research and technique 20100801
A prospective, randomized, placebo-controlled trial of zoledronic acid in bony metastatic bladder cancer. International journal of clinical oncology 20100801
In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients. Clinical and experimental immunology 20100801
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In postmenopausal women with osteoporosis, is zoledronic acid (Reclast) superior in improving T-scores and decreasing fracture rates when compared with placebo? The Journal of the Oklahoma State Medical Association 20100801
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Zoledronic acid protects against osteosarcoma-induced bone destruction but lacks efficacy against pulmonary metastases in a syngeneic rat model. International journal of cancer 20100715
Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells. The Biochemical journal 20100715
Effect of once-yearly zoledronic acid on the spine and hip as measured by quantitative computed tomography: results of the HORIZON Pivotal Fracture Trial. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100701
Economic evaluation of zoledronic acid for the prevention of osteoporotic fractures in postmenopausal women with early-stage breast cancer receiving aromatase inhibitors in the UK. Annals of oncology : official journal of the European Society for Medical Oncology 20100701
Response to zolendronic acid in children with type III osteogenesis imperfecta. Journal of bone and mineral metabolism 20100701
Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100701
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Bisphosphonates cause osteonecrosis of the jaw-like disease in mice. The American journal of pathology 20100701
Increased bone mineral density in a subset of patients with relapsed multiple myeloma who received the combination of bortezomib, dexamethasone and zoledronic acid. Annals of oncology : official journal of the European Society for Medical Oncology 20100701
Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis, and shows combined effects with other anticancer agents. Oncology reports 20100701
Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects. Clinical cancer research : an official journal of the American Association for Cancer Research 20100701
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[Long-term complete response in a patient with breast cancer and bone and pleura metastases after treatment with a combination of S-1 and zoledronic acid]. Gan to kagaku ryoho. Cancer & chemotherapy 20100701
Combined effects of bisphosphonate and radiation on osteosarcoma cells. Anticancer research 20100701
Effective salvage treatment of recurrent Ewing sarcoma utilizing chemotherapy and zoledronic acid. Clinical advances in hematology & oncology : H&O 20100701
Reversal of chemotherapy-induced leukopenia using granulocyte macrophage colony-stimulating factor promotes bone metastasis that can be blocked with osteoclast inhibitors. Cancer research 20100615
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Zoledronic acid concurrent with either high- or reduced-dose palliative radiotherapy in the management of the breast cancer patients with bone metastases: a phase IV randomized clinical study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20100601
Panoramic radiograph, computed tomography or magnetic resonance imaging. Which imaging technique should be preferred in bisphosphonate-associated osteonecrosis of the jaw? A prospective clinical study. Clinical oral investigations 20100601
Importance of microcracks in etiology of bisphosphonate-related osteonecrosis of the jaw: a possible pathogenetic model of symptomatic and non-symptomatic osteonecrosis of the jaw based on scanning electron microscopy findings. Clinical oral investigations 20100601
Orbital inflammatory disease secondary to a single-dose administration of zoledronic acid for treatment of postmenopausal osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100601
Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100601
Administration of the bisphosphonate zoledronic acid during tooth development inhibits tooth eruption and formation and induces dental abnormalities in rats. Calcified tissue international 20100601
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An in vitro assay to measure targeted drug delivery to bone mineral. ChemMedChem 20100503
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Zoledronic acid decreases mRNA six-transmembrane epithelial antigen of prostate protein expression in prostate cancer cells. Journal of endocrinological investigation 20100401
Zoledronic acid for treatment of osteopenia and osteoporosis in women with primary breast cancer undergoing adjuvant aromatase inhibitor therapy. Breast (Edinburgh, Scotland) 20100401
Exercise and zoledronic acid on lipid profile and bone remodeling in ovariectomized rats: a paradoxical negative association? Lipids 20100401
Bisphosphonate-related osteonecrosis of the jaw combined with jaw metastasis of prostate adenocarcinoma: report of a case. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20100401
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[Primary hyperparathyroidism in a patient with Paget's bone disease]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20100401
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Effect of IL-18 on expansion of gammadelta T cells stimulated by zoledronate and IL-2. Journal of immunotherapy (Hagerstown, Md. : 1997) 20100401
Generalized melanosis and melanuria in a patient with metastatic melanoma. Clinical and experimental dermatology 20100401
Health trends. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20100401
Zoledronic acid--once-yearly. Corticosteroid-induced osteoporosis: no benefit. Prescrire international 20100401
The effects of adding zoledronic acid to neoadjuvant chemotherapy on tumour response: exploratory evidence for direct anti-tumour activity in breast cancer. British journal of cancer 20100330
Combined effects of the bisphosphonate, zoledronic acid and the aromatase inhibitor letrozole on breast cancer cells in vitro: evidence of synergistic interaction. British journal of cancer 20100316
V gamma 9V delta 2 T lymphocytes efficiently recognize and kill zoledronate-sensitized, imatinib-sensitive, and imatinib-resistant chronic myelogenous leukemia cells. Journal of immunology (Baltimore, Md. : 1950) 20100315
Case 36-2009: A man with cough, hoarseness, and abnormalities on chest imaging. The New England journal of medicine 20100311
Multicenter, randomized, phase 2 study of zoledronic acid in combination with docetaxel and carboplatin in patients with unresectable stage IIIB or stage IV non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands) 20100301
Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20100301
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Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. Biochemical pharmacology 20100301
Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice. Journal of bone and mineral metabolism 20100301
No anti-angiogenic effect of clinical dosing regimens of a single zoledronic acid injection in an experimental bone healing site. Bone 20100301
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A single dose zoledronic acid enhances pin fixation in high tibial osteotomy using the hemicallotasis technique. A double-blind placebo controlled randomized study in 46 patients. Bone 20100301
Jaw bone changes in rats after treatment with zoledronate and pamidronate. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20100301
Use of zoledronic acid in the treatment of Gorham's disease. International journal of pediatric otorhinolaryngology 20100301
Effect of osteoporosis treatment on mortality: a meta-analysis. The Journal of clinical endocrinology and metabolism 20100301
Renal function changes and NHS resource use in breast cancer patients with metastatic bone disease treated with IV zoledronic acid or oral ibandronic acid: a four-centre non-interventional study. Journal of medical economics 20100301
Scintigraphic evaluation of mandibular bone turnover in patients with solid tumors receiving zoledronic acid. Oral oncology 20100301
The effect of zoledronate during bone healing. Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology 20100301
Effect of zoledronic acid on osseointegration of titanium implants: an experimental study in an ovariectomized rabbit model. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20100301
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Glucocorticoid-induced osteoporosis: management update. Current osteoporosis reports 20100301
FDA drug information that never reaches clinicians. The New England journal of medicine 20100211
Phase I trial of zoledronic acid + imatinib mesylate (Gleevec) in patients with bone metastases. American journal of clinical oncology 20100201
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Prevention of bone loss by zoledronic acid in premenopausal women undergoing adjuvant chemotherapy persist up to one year following discontinuing treatment. The Journal of clinical endocrinology and metabolism 20100201
Efficacy and safety of a once-yearly intravenous zoledronic acid 5 mg for fracture prevention in elderly postmenopausal women with osteoporosis aged 75 and older. Journal of the American Geriatrics Society 20100201
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Complete remission of lung metastasis following adoptive immunotherapy using activated autologous gammadelta T-cells in a patient with renal cell carcinoma. Anticancer research 20100201
Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxorubicin and zoledronic acid in a breast cancer model. International journal of cancer 20100115
Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells. The Journal of biological chemistry 20100115
Bone recovery after zoledronate therapy in thalassemia-induced osteoporosis: a meta-analysis and systematic review. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100101
Zoledronic acid induces apoptosis and changes the TRAIL/OPG ratio in breast cancer cells. Cancer letters 20100101
Cancer treatment dosing regimens of zoledronic acid result in near-complete suppression of mandible intracortical bone remodeling in beagle dogs. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100101
Potential mediators of the mortality reduction with zoledronic acid after hip fracture. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100101
The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation. International journal of cancer 20100101
Non-persistent effect of short-term bisphosphonate treatment in preventing fractures after liver transplantation. Transplant international : official journal of the European Society for Organ Transplantation 20100101
Bisphosphonates do not inhibit periosteal bone formation in estrogen deficient animals and allow enhanced bone modeling in response to mechanical loading. Bone 20100101
Differences between bisphosphonates in binding affinities for hydroxyapatite. Journal of biomedical materials research. Part B, Applied biomaterials 20100101
Bortezomib and zoledronic acid on angiogenic and vasculogenic activities of bone marrow macrophages in patients with multiple myeloma. European journal of cancer (Oxford, England : 1990) 20100101
Skeletal morbidity in lung cancer patients with bone metastases: demonstrating the need for early diagnosis and treatment with bisphosphonates. Lung cancer (Amsterdam, Netherlands) 20100101
Is zoledronate toxic to human periodontal fibroblasts? Journal of dental research 20100101
Dysuria caused by pelvic metastasis from breast carcinoma was alleviated by multi-modality therapy with zoledronic acid. The breast journal 20100101
Zoledronic acid: an unending tale for an antiresorptive agent. Expert opinion on pharmacotherapy 20100101
IgE-type multiple myeloma with the late development of IgA2 kappa and plasma cell leukaemia. Pathology 20100101
Cost-effectiveness model of using zoledronic acid once a year versus current treatment strategies in postmenopausal osteoporosis. Joint, bone, spine : revue du rhumatisme 20100101
Cytotoxic effect of zoledronic acid-loaded bone cement on giant cell tumor, multiple myeloma, and renal cell carcinoma cell lines. The Journal of bone and joint surgery. American volume 20100101
A clinico-pathologic correlation. Bisphosphonate-related osteonecrosis of the jaws. Journal of the Massachusetts Dental Society 20100101
Dual-energy X-ray absorptiometry and quantitative ultrasound in patients with Paget's disease of bone before and after treatment with zoledronic acid: association with serum bone markers and Dickkopf-1. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 20100101
Risk factors contributing to the development of hypocalcemia after zoledronic acid administration in patients with bone metastases of solid tumor. Biological & pharmaceutical bulletin 20100101
Adding zoledronic acid to endocrine therapy in the adjuvant treatment of hormone-sensitive breast cancer in premenopausal women: a new care standard or a provocative idea? Current oncology reports 20100101
Microvascular endothelial cell responses in vitro and in vivo: modulation by zoledronic acid and paclitaxel? Journal of vascular research 20100101
Renal toxicity in patients with multiple myeloma receiving zoledronic acid vs. ibandronate: a retrospective medical records review. Journal of cancer research and therapeutics 20100101
Zoledronic acid treatment of osteoporosis: effects in men. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20100101
[Effects of zoledronic acid in adults with osteogenesis imperfecta]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20100101
Osteonecrosis of the jaw after a single bisphosphonate infusion in a patient with metastatic renal cancer treated with sunitinib. Onkologie 20100101
Bisphosphonate treatment in polyostotic fibrous dysplasia of the cranium: case report and literature review. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20100101
The impact of bisphosphonates on the osteoblast proliferation and Collagen gene expression in vitro. Head & face medicine 20100101
Titration of dosage for the protective effect of zoledronic acid on bone loss in patients submitted to androgen deprivation therapy due to prostate cancer: a prospective open-label study. Urologia internationalis 20100101
Results of the Zometa cost-utility model for the german healthcare system based on the results of the ABCSG-12 study. Onkologie 20100101
Enhancing cytotoxic and apoptotic effect in OVCAR-3 and MDAH-2774 cells with all-trans retinoic acid and zoledronic acid: a paradigm of synergistic molecular targeting treatment for ovarian cancer. Journal of experimental & clinical cancer research : CR 20100101
Zoledronate stimulates gamma delta T cells in prostate cancer patients. Oncology research 20100101
Bisphosphonate treatment of aggressive primary, recurrent and metastatic Giant Cell Tumour of Bone. BMC cancer 20100101
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Adverse events and intravenous versus oral bisphosphonate use in patients with osteoporosis and cancer in the U.S. General dentistry 20100101
Lysis of aminobisphosphonate-sensitized MCF-7 breast tumor cells by Vγ9Vδ2 T cells. Cancer immunity 20100101
Orbital inflammation after use of zoledronic acid for metastasized prostate carcinoma. Bulletin de la Societe belge d'ophtalmologie 20100101
Post-surgery severe hypocalcemia in primary hyperparathyroidism preoperatively treated with zoledronic acid. Hormones (Athens, Greece) 20100101
Zoledronic acid: clinical utility and patient considerations in osteoporosis and low bone mass. Drug design, development and therapy 20100101
Effect of zoledronic acid used in the root surface treatment of late replanted teeth: a study in rats. Brazilian dental journal 20100101
Dose-dependent metabolic effect of zoledronate on primary human osteoblastic cell cultures. Clinical and experimental rheumatology 20100101
The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice. PloS one 20100101
Dental extractions in patient treated with intravenous bisphosphonates and risk of osteonecrosis of jaws: presentation of a preventive protocol and case series. Minerva stomatologica 20100101
Skull base osteomyelitis and bisphosphonate use in multiple myeloma: report of two cases and literature review. The Laryngoscope 20100101
Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome. Nucleus (Austin, Tex.) 20100101
Zoledronic acid in metastatic bone disease: an audit based discussion. Journal of Ayub Medical College, Abbottabad : JAMC 20100101
Bisphosphonate-related osteonecrosis of the jaw and left thumb. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091210
Aminobisphosphonate stimulates bone regeneration and enforces consolidation of titanium implant into a new rat caudal vertebrae model. Pathology oncology research : POR 20091201
A novel bioassay model to determine clinically significant bisphosphonate levels. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20091201
The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro. Bone 20091201
Bone morphogenetic proteins and zoledronic acid. Annals of oncology : official journal of the European Society for Medical Oncology 20091201
The influence of chemotherapy on bone mineral density, quantitative ultrasonometry and bone turnover in pre-menopausal women with breast cancer. European journal of cancer (Oxford, England : 1990) 20091201
Extended use of intravenous bisphosphonate therapy for the prevention of skeletal complications in patients with cancer. Cancer investigation 20091201
Preserving bone health in patients with hormone-sensitive prostate cancer: the role of bisphosphonates. BJU international 20091201
[New development in breast cancer therapy. III. Zoledronic acid and anti-tumor immunity in breast cancer]. Gan to kagaku ryoho. Cancer & chemotherapy 20091201
A rare case of Paget's disease of the bone in the Philippines. International journal of rheumatic diseases 20091201
Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091110
Systemic effects of zoledronic acid in children with traumatic femoral head avascular necrosis and Legg-Calve-Perthes disease. Bone 20091101
Cyr61 downmodulation potentiates the anticancer effects of zoledronic acid in androgen-independent prostate cancer cells. International journal of cancer 20091101
The effect of zoledronic acid on serum dickkopf-1, osteoprotegerin, and RANKL in patients with Paget's disease of bone. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20091101
Targeting apoptosis in the hormone- and drug-resistant prostate cancer cell line, DU-145, by gossypol/zoledronic acid combination. Cell biology international 20091101
Bisphosphonates in breast cancer: teaching an old dog new tricks. Current opinion in oncology 20091101
Intravenous zoledronic acid to prevent osteoporosis in a veteran population with multiple risk factors for bone loss on androgen deprivation therapy. The Journal of urology 20091101
A case of bone, lung, pleural and liver metastases from renal cell carcinoma which responded remarkably well to zoledronic acid monotherapy. Japanese journal of clinical oncology 20091101
Locally delivered bisphosphonate for enhancement of bone formation and implant fixation. The Journal of bone and joint surgery. American volume 20091101
Cutting the limits of aminobisphosphonates: new strategies for the potentiation of their anti-tumour effects. Current cancer drug targets 20091101
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[Management of serum calcium with cinacelet in parathyroid cancer]. Ugeskrift for laeger 20091005
Cocultures of osteoblasts and osteoclasts are influenced by local application of zoledronic acid incorporated in a poly(D,L-lactide) implant coating. Journal of biomedical materials research. Part A 20091001
Immediate versus delayed zoledronic acid for prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen-N03CC. Breast cancer research and treatment 20091001
The impact of zoledronic acid therapy in survival of lung cancer patients with bone metastasis. International journal of cancer 20091001
Antitumoral effect of the bisphosphonate zoledronic acid against visceral metastases in an adrenocortical cancer patient. Annals of oncology : official journal of the European Society for Medical Oncology 20091001
Transient secondary hyperparathyroidism following intravenous infusion of zoledronic acid. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20091001
Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone. Molecular cancer therapeutics 20091001
Bifocal sarcomatous transformation of Paget's disease: a case report. Joint, bone, spine : revue du rhumatisme 20091001
Multidisciplinary treatment including sorafenib stabilized the bone metastases of renal cell carcinoma in an immunosuppressed renal transplant recipient. International journal of clinical oncology 20091001
Management of metastatic bone pain with repeated doses of rhenium 186-HEDP in patients under therapy with zoledronic acid: a safe and additively effective practice. Cancer biotherapy & radiopharmaceuticals 20091001
High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical properties. Clinical cancer research : an official journal of the American Association for Cancer Research 20090915
Superparamagnetic nanovector with anti-cancer properties: gamma Fe2O3@Zoledronate. International journal of pharmaceutics 20090911
Bisphosphonate-associated osteonecrosis of the jaws: the limits of a conservative approach. Head & neck 20090901
Effects of yearly zoledronic acid 5 mg on bone turnover markers and relation of PINP with fracture reduction in postmenopausal women with osteoporosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20090901
Slow zoledronic acid releasing testis prostheses in the treatment of prostate cancer patients with bone metastases. Medical hypotheses 20090901
Zoledronic acid may be a treatment option for hyperparathyroidism. Medical hypotheses 20090901
Adult T-cell leukemia/lymphoma in the Middle East: first report of two cases from Lebanon. Transfusion 20090901
The rabbit biodistribution of a therapeutic dose of zoledronic acid labeled with Tc-99m. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20090901
Mesenchymal cells inhibit expansion but not cytotoxicity exerted by gamma-delta T cells. European journal of clinical investigation 20090901
Effect of once-yearly zoledronic acid five milligrams on fracture risk and change in femoral neck bone mineral density. The Journal of clinical endocrinology and metabolism 20090901
Zoledronic acid decreases bone formation without causing osteocyte death in mice. Archives of oral biology 20090901
A case of resistant hypercalcemia of malignancy with a proposed treatment algorithm. The Annals of pharmacotherapy 20090901
New therapies for osteoporosis: zoledronic acid, bazedoxifene, and denosumab. Current osteoporosis reports 20090901
Clinical efficacy and safety of zoledronic acid in prostate and breast cancer. Expert review of anticancer therapy 20090901
Docetaxel-based chemotherapy with zoledronic acid and prednisone in hormone refractory prostate cancer: factors predicting response and survival. International journal of urology : official journal of the Japanese Urological Association 20090901
Editorial Comment to docetaxel-based combination chemotherapy with zoledronic acid and prednisone in hormone refractory prostate cancer: Factors predicting response and survival. International journal of urology : official journal of the Japanese Urological Association 20090901
[Antitumor activity of zoledronic acid]. Magyar onkologia 20090901
Combined gossypol and zoledronic acid treatment results in synergistic induction of cell death and regulates angiogenic molecules in ovarian cancer cells. European cytokine network 20090901
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Determination of rat vertebral bone compressive fatigue properties in untreated intact rats and zoledronic-acid-treated, ovariectomized rats. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090801
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Single infusion of zoledronic acid to prevent androgen deprivation therapy-induced bone loss in men with hormone-naive prostate carcinoma. Cancer 20090801
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Does exercise modify the effects of zoledronic acid on bone mass, microarchitecture, biomechanics, and turnover in ovariectomized rats? Calcified tissue international 20090801
[Numb chin syndrome caused by biphosphonates-induced osteonecrosis of the jaw]. Revista de neurologia 20090801
Mandibular necrosis in beagle dogs treated with bisphosphonates. Orthodontics & craniofacial research 20090801
Multimodal therapy for vertebral involvement of systemic mastocytosis. Spine 20090801
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Zolendronate in osteogenesis imperfecta. Journal of pediatric endocrinology & metabolism : JPEM 20090801
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Pilot study on the use of zoledronic acid to prevent bone loss in allo-SCT recipients. Bone marrow transplantation 20090701
Antifracture efficacy and reduction of mortality in relation to timing of the first dose of zoledronic acid after hip fracture. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20090701
Endocrine effects of adjuvant letrozole compared with tamoxifen in hormone-responsive postmenopausal patients with early breast cancer: the HOBOE trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090701
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Intravenous bisphosphonate-related osteonecrosis of the jaw: bone scintigraphy as an early indicator. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20090701
Treatment of painful bone metastases in hormone-refractory prostate cancer with zoledronic acid and samarium-153-ethylenediaminetetramethylphosphonic acid combined. Journal of palliative medicine 20090701
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Effect of locally administered zoledronic acid on injury-induced intramembranous bone regeneration and osseointegration of a titanium implant in rats. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20090701
Comparison of phenotype of gammadelta T cells generated using various cultivation methods. Immunology letters 20090630
Biennial [corrected] IV zoledronic acid (Reclast) for prevention of osteoporosis. The Medical letter on drugs and therapeutics 20090629
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Bisphosphonate zoledronic acid enhances the inhibitory effects of gefitinib on EGFR-mutated non-small cell lung carcinoma cells. Cancer letters 20090608
Intravenous zoledronate improves bone density in adults with cystic fibrosis (CF). Clinical endocrinology 20090601
Comment on: Bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients. Oral oncology 20090601
Risk of renal impairment after treatment with ibandronate versus zoledronic acid: a retrospective medical records review. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20090601
Regression of melanoma metastases following treatment with the n-bisphosphonate zoledronate and localised radiotherapy. Clinical immunology (Orlando, Fla.) 20090601
Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro. British journal of pharmacology 20090601
Osteoprotegerin abrogated cortical porosity and bone marrow fibrosis in a mouse model of constitutive activation of the PTH/PTHrP receptor. The American journal of pathology 20090601
Complete and lasting healing of bone melanoma metastasis after hyperthermic limb perfusion. Melanoma research 20090601
Pathological fractures in patients caused by bisphosphonate-related osteonecrosis of the jaws: report of 3 cases. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20090601
Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes. Journal of immunology (Baltimore, Md. : 1950) 20090601
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Death receptor 5 agonist TRA8 in combination with the bisphosphonate zoledronic acid attenuated the growth of breast cancer metastasis. Cancer biology & therapy 20090601
[Zoledronic acid blocks cell cycle and induces apoptosis in lung cancer cell line 95D cells and their mechanisms of action]. Zhonghua zhong liu za zhi [Chinese journal of oncology] 20090601
Endocrine therapy plus zoledronic acid in premenopausal breast cancer. The New England journal of medicine 20090528
Endocrine therapy plus zoledronic acid in premenopausal breast cancer. The New England journal of medicine 20090528
Endocrine therapy plus zoledronic acid in premenopausal breast cancer. The New England journal of medicine 20090528
Endocrine therapy plus zoledronic acid in premenopausal breast cancer. The New England journal of medicine 20090528
Endocrine therapy plus zoledronic acid in premenopausal breast cancer. The New England journal of medicine 20090528
Endocrine therapy plus zoledronic acid in premenopausal breast cancer. The New England journal of medicine 20090528
Zoledronic acid inhibits both the osteolytic and osteoblastic components of osteosarcoma lesions in a mouse model. Clinical cancer research : an official journal of the American Association for Cancer Research 20090515
Bone turnover markers as predictive tools for skeletal complications in men with metastatic prostate cancer treated with zoledronic acid. The Prostate 20090501
Hyperparathyroidism secondary to zoledronic acid infusion: case report. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20090501
Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 surgical cases. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20090501
Vascular endothelial growth factor activity after switching of bisphosphonate treatment for metastatic breast cancer. Journal of clinical pathology 20090501
Serum Dickkopf-1 is increased and correlates with reduced bone mineral density in patients with thalassemia-induced osteoporosis. Reduction post-zoledronic acid administration. Haematologica 20090501
High incidence of hypocalcemia and serum creatinine increase in patients with bone metastases treated with zoledronic acid. The oncologist 20090501
Zoledronic acid effectively prevents aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: Z-FAST study 36-month follow-up results. Clinical breast cancer 20090501
Pulse treatment with zoledronic acid causes sustained commitment of bone marrow derived mesenchymal stem cells for osteogenic differentiation. Bone 20090501
The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts. Bone 20090501
Efficacy of clodronate, pamidronate, and zoledronate in reducing morbidity and mortality in cancer patients with bone metastasis: a meta-analysis of randomized clinical trials. Clinical therapeutics 20090501
Glucocorticoid-induced osteoporosis: hope on the HORIZON. Lancet (London, England) 20090411
Zoledronic acid and risedronate in the prevention and treatment of glucocorticoid-induced osteoporosis (HORIZON): a multicentre, double-blind, double-dummy, randomised controlled trial. Lancet (London, England) 20090411
Controlled release of bisphosphonate from a calcium phosphate biomaterial inhibits osteoclastic resorption in vitro. Journal of biomedical materials research. Part A 20090401
Intravesical administration of gammadelta T cells successfully prevents the growth of bladder cancer in the murine model. Cancer immunology, immunotherapy : CII 20090401
Re: Christian Walter, Bilal Al-Nawas, Knut A. Grötz, et al. Prevalence and risk factors of bisphosphonate-associated osteonecrosis of the jaw in prostate cancer patients with advanced disease treated with zoledronate. Eur Urol 2008;54:1066-72. European urology 20090401
Bone structure and remodelling in stroke patients: early effects of zoledronate. Bone 20090401
Activated human gammadelta T cells as stimulators of specific CD8+ T-cell responses to subdominant Epstein Barr virus epitopes: potential for immunotherapy of cancer. Journal of immunotherapy (Hagerstown, Md. : 1997) 20090401
Zoledronic acid-induced regression of multiple metastases at nonskeletal sites. Annals of oncology : official journal of the European Society for Medical Oncology 20090401
Bisphosphonate-related osteonecrosis of the jaws: a single-center study of 101 patients. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20090401
Medical oncology: zoledronic acid prevents bone loss in early-stage breast cancer. Nature reviews. Clinical oncology 20090401
Indirect antitumor effects of bisphosphonates on prostatic LNCaP cells co-cultured with bone cells. Anticancer research 20090401
Paget's disease of bone and osteonecrosis. Dental update 20090401
Zoledronic acid and interleukin-2 treatment improves immunocompetence in HIV-infected persons by activating Vgamma9Vdelta2 T cells. AIDS (London, England) 20090313
Oral osteonecrosis associated with the use of zoledronic acid: first case of a patient with advanced pancreatic cancer and bone metastases. JOP : Journal of the pancreas 20090309
[Atrial fibrillation during bisphosphonate therapy. side effects or coincidental finding?]. MMW Fortschritte der Medizin 20090305
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Radiotherapy to bone metastases from renal cell carcinoma with or without zoledronate. BJU international 20090301
Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. British journal of haematology 20090301
Positron-emission tomography imaging in the diagnosis of bisphosphonate-related osteonecrosis of the jaw. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20090301
The effect of surface immobilized bisphosphonates on the fixation of hydroxyapatite-coated titanium implants in ovariectomized rats. Biomaterials 20090301
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Effects of platelet-derived growth factor, vitamin D and parathyroid hormone on osteoblasts derived from cancer patients on chronic bisphosphonate therapy. International journal of molecular medicine 20090301
The role of inferior alveolar nerve involvement in bisphosphonate-related osteonecrosis of the jaw. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20090301
Recurrent low-energy femoral shaft fractures and osteonecrosis of the jaw in a case of multiple myeloma treated with bisphosphonates. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20090301
Bisphosphonate-related osteonecrosis of the skull base. The Laryngoscope 20090301
[Once-yearly administration of zoledronic acid to treat post-menopausal osteoporosis]. Der Unfallchirurg 20090301
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Induction of gamma delta T cells using zoledronate plus interleukin-2 in patients with metastatic cancer. Hiroshima journal of medical sciences 20090301
[Primary hyperparathyroidism. An alternative to the surgery]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20090301
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Systemic therapy for advancing or metastatic prostate cancer (STAMPEDE): a multi-arm, multistage randomized controlled trial. BJU international 20090201
Change in markers of bone metabolism with chemotherapy for advanced prostate cancer: interleukin-6 response is a potential early indicator of response to therapy. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20090201
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The antiresorptive effects of a single dose of zoledronate persist for two years: a randomized, placebo-controlled trial in osteopenic postmenopausal women. The Journal of clinical endocrinology and metabolism 20090201
Effect of combined local treatment with zoledronic acid and basic fibroblast growth factor on implant fixation in ovariectomized rats. Bone 20090201
Docetaxel/zoledronic acid combination triggers apoptosis synergistically through downregulating antiapoptotic Bcl-2 protein level in hormone-refractory prostate cancer cells. Cell biology international 20090201
Activity and safety of a prolonged daily schedule of zoledronic acid in a patient with bone metastases from urothelial carcinoma. Annals of oncology : official journal of the European Society for Medical Oncology 20090201
Bisphosphonate-related osteonecrosis of the jaw and its associated risk factors: a Belgian case series. The Laryngoscope 20090201
The effect of a single infusion of zoledronic acid on early implant migration in total hip arthroplasty. A randomized, double-blind, controlled trial. The Journal of bone and joint surgery. American volume 20090201
[Bisphosphonates and other new therapeutic agents for the treatmednt of osteogenesis imperfecta]. Clinical calcium 20090201
Efficacy of bisphosphonates in reducing fracture risk in postmenopausal osteoporosis. The American journal of medicine 20090201
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[Bisphosphonate-associated osteonecrosis of the jaw in patients with multiple myeloma]. Ugeskrift for laeger 20090105
A double-blinded, randomized controlled trial of zoledronate therapy for HIV-associated osteopenia and osteoporosis. AIDS (London, England) 20090102
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Zoledronate reverses mandibular bone loss in osteoprotegerin-deficient mice. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090101
Anti-angiogenic property of zoledronic acid by inhibition of endothelial progenitor cell differentiation. The Journal of surgical research 20090101
Consequence of therapy discontinuation in bisphosphonate-associated osteonecrosis of the jaws. The British journal of oral & maxillofacial surgery 20090101
Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. The experience of the National Cancer Institute of Milan. Annals of oncology : official journal of the European Society for Medical Oncology 20090101
Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid. Annals of oncology : official journal of the European Society for Medical Oncology 20090101
Zoledronic acid for the treatment of appendicular osteosarcoma in a dog. The Journal of small animal practice 20090101
Complexes of low energy beta emitters 47Sc and 177Lu with zoledronic acid for bone pain therapy. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20090101
Inhibition of osteoblast function in vitro by aminobisphosphonates. Journal of cellular biochemistry 20090101
Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP. British journal of haematology 20090101
Zoledronic acid in treatment of bone lesions by Langerhans cell histiocytosis. Journal of bone and mineral metabolism 20090101
Bisphosphonate-induced osteonecrosis of the jaws, bone markers, and a hypothesized candidate gene. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20090101
Zoledronic acid induces caspase-dependent apoptosis in renal cancer cell lines. Scandinavian journal of urology and nephrology 20090101
Activated V gamma 9V delta 2 T cells trigger granulocyte functions via MCP-2 release. Journal of immunology (Baltimore, Md. : 1950) 20090101
San Antonio Breast Cancer Symposium. The Lancet. Oncology 20090101
[New development in bisphosphonate treatment. Characteristics and effectiveness of intermittent bisphophonates]. Clinical calcium 20090101
Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in severe combined immunodeficient mice. Molecular cancer therapeutics 20090101
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[A case of recurrent breast carcinoma metastasis successfully treated with S-1 and zoledronic acid therapy]. Gan to kagaku ryoho. Cancer & chemotherapy 20090101
Severe symptomatic hypocalcemia in a patient with RDEB treated with intravenous zoledronic acid. Archives of dermatology 20090101
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Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. BMC cancer 20090101
Osteonecrosis of the jaw in patients with multiple myeloma treated with zoledronic acid. Journal of bone and mineral metabolism 20090101
Effect of zoledronic acid on bone pain secondary to metastatic bone disease. Medicine and health, Rhode Island 20090101
Radiological changes following second-line zoledronic acid treatment in breast cancer patients with bone metastases. Clinical & experimental metastasis 20090101
Safety and efficacy of intravenous zoledronic acid in paediatric osteoporosis. Journal of pediatric endocrinology & metabolism : JPEM 20090101
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Imaging findings of bisphosphonate-related osteonecrosis of the jaw with emphasis on early magnetic resonance imaging findings. Journal of computer assisted tomography 20090101
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A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis. Arthritis research & therapy 20090101
Introduction to sessions on guidelines and endocrine therapy, the influence of breast screening on number of mastectomies and the challenge between molecular science and traditional dogma in the treatment of breast cancer. Introduction to Session 6. Breast cancer research : BCR 20090101
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Unilateral anterior uveitis complicating zoledronic acid therapy in prostate cancer. The Journal of rheumatology 20081201
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Collagen telopeptide (serum CTX) and its relationship with the size and number of lesions in osteonecrosis of the jaws in cancer patients on intravenous bisphosphonates. Oral oncology 20081101
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Mechanisms of the action of zoledronic acid on human MG-63 osteosarcoma cells. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20081101
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Zoledronic acid modulates antitumoral responses of prostate cancer-tumor associated macrophages. Cancer immunology, immunotherapy : CII 20081001
Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20081001
Bisphosphonate-related osteonecrosis of the jaws: a case-control study of risk factors in breast cancer patients. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20081001
Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling. Bone 20081001
Hypercalcemia due to an interaction of all-trans retinoic acid (ATRA) and itraconazole therapy for acute promyelocytic leukemia successfully treated with zoledronic acid. European journal of clinical pharmacology 20081001
Biodistribution and plasma protein binding of zoledronic acid. Drug metabolism and disposition: the biological fate of chemicals 20081001
A multicenter, randomized clinical trial comparing zoledronic acid versus observation in patients with asymptomatic myeloma. Cancer 20081001
Continuous improvement of bone mineral density two years post zoledronic acid discontinuation in patients with thalassemia-induced osteoporosis: long-term follow-up of a randomized, placebo-controlled trial. Haematologica 20081001
STAMPEDE: Systemic Therapy for Advancing or Metastatic Prostate Cancer--a multi-arm multi-stage randomised controlled trial. Clinical oncology (Royal College of Radiologists (Great Britain)) 20081001
Zoledronic acid markedly improves bone mineral density for patients with monoclonal gammopathy of undetermined significance and bone loss. Clinical cancer research : an official journal of the American Association for Cancer Research 20081001
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[Newly developed drugs for osteoporosis in overseas and their future roles for the therapy]. Clinical calcium 20081001
Local application of zoledronic acid incorporated in a poly(D,L-lactide)-coated implant accelerates fracture healing in rats. Acta orthopaedica 20081001
A tale of three diseases of the bone. Singapore medical journal 20081001
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Manipulating the anabolic and catabolic response in bone graft remodeling: synergism by a combination of local BMP-7 and a single systemic dosis of zoledronate. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20080901
Renal safety of annual zoledronic acid infusions in osteoporotic postmenopausal women. Kidney international 20080901
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Once-yearly intravenous zoledronate does not impair renal function in postmenopausal women. Kidney international 20080901
Short-term effects of high-dose zoledronic acid treatment on bone mineralization density distribution after orthotopic liver transplantation. Calcified tissue international 20080901
Influence of early and late zoledronic acid administration on vertebral structure and strength in ovariectomized rats. Calcified tissue international 20080901
Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 5-year follow-up of the ABCSG-12 bone-mineral density substudy. The Lancet. Oncology 20080901
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[Update on treatment of postmenopausal osteoporosis]. Revue medicale de Bruxelles 20080901
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Impact of skeletal complications on patients' quality of life, mobility, and functional independence. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20080801
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[Zoledronic acid for preventing fractures]. Der Internist 20080801
Maximizing effectiveness of bisphosphonate therapy for osteoporosis. Southern medical journal 20080801
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Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study. European cells & materials 20080731
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Differential effect of doxorubicin and zoledronic acid on intraosseous versus extraosseous breast tumor growth in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research 20080715
Zoledronic acid is effective against experimental malignant pleural effusion. American journal of respiratory and critical care medicine 20080701
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Zoledronic acid decreased osteolysis but not bone metastasis in a nude mouse model of canine prostate cancer with mixed bone lesions. The Prostate 20080701
The effects of bisphosphonates on osteoblasts in vitro. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20080701
Once-yearly administered intravenous zoledronic acid for postmenopausal osteoporosis. The Annals of pharmacotherapy 20080701
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Malignant pleural effusions: fixing the leaky faucet. American journal of respiratory and critical care medicine 20080701
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Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. Nature medicine 20080701
Rejuvenating premature aging. Nature medicine 20080701
[A case of hormone/docetaxel-refractory prostate cancer in which PSA level decreased after docetaxel+zoledronic acid treatment]. Gan to kagaku ryoho. Cancer & chemotherapy 20080701
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Changes of bone turnover markers and serum PTH after night or morning administration of zoledronic acid in breast cancer patients with bone metastases. British journal of cancer 20080603
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Preclinical evidence for nitrogen-containing bisphosphonate inhibition of farnesyl diphosphate (FPP) synthase in the kidney: implications for renal safety. Toxicology in vitro : an international journal published in association with BIBRA 20080601
Bisphosphonates induce apoptosis in CLL cells independently of MDR phenotype. Cancer chemotherapy and pharmacology 20080601
RAD001 (Everolimus) inhibits growth of prostate cancer in the bone and the inhibitory effects are increased by combination with docetaxel and zoledronic acid. The Prostate 20080601
The bisphosphonate zoledronic acid inhibits the growth of HCT-116 colon carcinoma cells and induces tumor cell apoptosis. Apoptosis : an international journal on programmed cell death 20080601
Paget's disease and bisphosphonate-associated osteonecrosis of the jaws. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20080601
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Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells. Journal of cellular and molecular medicine 20080601
Pulmonary strongyloidiasis mimicking cancer symptoms: a case of hyperinfection in a patient with metastatic lung cancer. American journal of clinical oncology 20080601
[Treatment of multiple angiomatosis involving the skeleton and the abdominal and thoracic cavities with interferon alpha, thalidomide and zoledronate]. Vnitrni lekarstvi 20080601
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Prevention of strain-related osteopenia in aseptic loosening of hip prostheses using perioperative bisphosphonate. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20080501
Inhibition of osteoclasts does not prevent joint ankylosis in a mouse model of spondyloarthritis. Rheumatology (Oxford, England) 20080501
Comparison of the effects of genistein and zoledronic acid on the bone loss in OPG-deficient mice. Bone 20080501
Histomorphometric evaluation of the effects of zoledronic acid on mandibular distraction osteogenesis in rabbits. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20080501
Farnesyl pyrophosphate synthase enantiospecificity with a chiral risedronate analog, [6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501): Synthetic, structural, and modeling studies. Bioorganic & medicinal chemistry letters 20080501
A once-yearly IV bisphosphonate for osteoporosis. Obstetrics and gynecology 20080501
Randomised study of single dose (8 Gy vs. 6 Gy) of analgesic radiotherapy plus zoledronic acid in patients with bone metastases. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20080501
Single annual injectable treatment for postmenopausal osteoporosis. Expert opinion on drug delivery 20080501
Use of intravenous bisphosphonates in older women with breast cancer. The oncologist 20080501
Integrated analysis of zoledronic acid for prevention of aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole. The oncologist 20080501
[Effectiveness and tolerability of zoledronic acid in the treatment of metastatic prostate cancer]. Actas urologicas espanolas 20080501
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Long-term protective effects of zoledronic acid on cancellous and cortical bone in the ovariectomized rat. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20080401
Combined use of zoledronic acid and 153Sm-EDTMP in hormone-refractory prostate cancer patients with bone metastases. European journal of nuclear medicine and molecular imaging 20080401
How effective is bisphosphonate treatment for preventing bone fractures after liver transplantation? Nature clinical practice. Gastroenterology & hepatology 20080401
[Zoledronic acid for preventing fractures. HORIZON trial (Health Outcomes and Reduced Incidence with Zoledronic acid ONce yearly)]. Der Internist 20080401
Zoledronate, smoking, and obesity are strong risk factors for osteonecrosis of the jaw: a case-control study. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20080401
Zoledronic acid for cancer therapy--induced and postmenopausal bone loss. Expert opinion on pharmacotherapy 20080401
[Bony lesion with prostate cancer]. Clinical calcium 20080401
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Multiple bone lesions resembling a metastatic origin. An unexpected diagnosis. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20080401
The effects of zoledronic acid on serum lipids in multiple myeloma patients. Calcified tissue international 20080401
Bisphosphonates and osteonecrosis of the jaw: a case report. Clinics (Sao Paulo, Brazil) 20080401
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Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: definition and management of the risk related to zoledronic acid. Clinical lymphoma & myeloma 20080401
Case records of the Massachusetts General Hospital. Case 9-2008. A 65-year-old woman with a nonhealing ulcer of the jaw. The New England journal of medicine 20080320
Acute unilateral anterior uveitis and scleritis following a single infusion of zoledronate for metastatic breast cancer. The Medical journal of Australia 20080317
[Osteoporosis--new therapeutic possibilities. The Danish Bone Society]. Ugeskrift for laeger 20080317
Multicentric reticulohistiocytosis: a systemic osteoclastic disease? Arthritis and rheumatism 20080315
Copulsing tumor antigen-pulsed dendritic cells with zoledronate efficiently enhance the expansion of tumor antigen-specific CD8+ T cells via Vgamma9gammadelta T cell activation. Journal of leukocyte biology 20080301
Concurrent administration of zoledronic acid and irradiation leads to improved bone density, biomechanical strength, and microarchitecture in a mouse model of tumor-induced osteolysis. Journal of surgical oncology 20080301
Development of a low-dose anti-resorptive drug regimen reveals synergistic suppression of bone formation when coupled with disuse. Journal of applied physiology (Bethesda, Md. : 1985) 20080301
Effective inhibition of aromatase inhibitor-associated bone loss by zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: ZO-FAST Study results. Cancer 20080301
A review of Paget's disease of bone with a focus on the efficacy and safety of zoledronic acid 5 mg. Current medical research and opinion 20080301
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Zoledronate, fractures, and mortality after hip fracture. The New England journal of medicine 20080227
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Relevance of a new rat model of osteoblastic metastases from prostate carcinoma for preclinical studies using zoledronic acid. International journal of cancer 20080215
Management of pain in elderly patients receiving infusion of zoledronic acid for bone metastasis: a single-institution report. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20080201
Circulating cathepsin K and cystatin C in patients with cancer related bone disease: clinical and therapeutic implications. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080201
Weekly docetaxel, zoledronic acid and estramustine in hormone-refractory prostate cancer (HRPC). Investigational new drugs 20080201
Zoledronic acid is unable to induce apoptosis, but slows tumor growth and prolongs survival for non-small-cell lung cancers. Lung cancer (Amsterdam, Netherlands) 20080201
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Modeling bone morphogenetic protein and bisphosphonate combination therapy in wild-type and Nf1 haploinsufficient mice. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20080101
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Thirteen cases of jaw osteonecrosis in patients on bisphosphonate therapy. Joint, bone, spine : revue du rhumatisme 20080101
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Continuous increase in erythropoietic activity despite the improvement in bone mineral density by zoledronic acid in patients with thalassemia intermedia-induced osteoporosis. Acta haematologica 20080101
Zoledronic acid: a pharmacoeconomic review of its use in the management of bone metastases. PharmacoEconomics 20080101
In vivo and in vitro efficacy of zoledronate for treating oral squamous cell carcinoma in cats. Journal of veterinary internal medicine 20080101
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Safety and efficacy of zoledronic acid rapid infusion in lung cancer patients with bone metastases: a single institution experience. Anticancer research 20080101
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A case report: zoledronic acid-induced anterior uveitis. Medical oncology (Northwood, London, England) 20080101
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Renal toxicity following zoledronic acid reversed with ibandronate in a prostate cancer patient with bone metastases. Urologia internationalis 20080101
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Zoledronic acid effects interleukin-6 expression in hormone-independent prostate cancer cell lines. International braz j urol : official journal of the Brazilian Society of Urology 20080101
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The bisphosphonate, zoledronic acid reduces experimental neuroblastoma growth by interfering with tumor angiogenesis. Anticancer research 20080101
Bone metastasis in hepatocellular carcinoma: need for reappraisal of treatment. Journal of cancer research and therapeutics 20080101
Zoledronic acid increases docetaxel cytotoxicity through pMEK and Mcl-1 inhibition in a hormone-sensitive prostate carcinoma cell line. Journal of translational medicine 20080101
Therapy with zoledronic acid, 5 mg, for a patient with Paget disease of bone. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20080101
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Zoledronic acid: a review of its use in the treatment of osteoporosis. Drugs & aging 20080101
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A prospective, multicenter, open-label trial of zoledronic acid in patients with hormone refractory prostate cancer. Yonsei medical journal 20071231
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Reclast approved for osteoporosis treatment in postmenopausal women. The Nurse practitioner 20071201
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Emerging strategies in bone health management for the adjuvant patient. Seminars in oncology 20071201
Reducing the risk of cancer treatment-associated bone loss in patients with breast cancer. Seminars in oncology 20071201
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Zoledronic acid inhibits osteosarcoma growth in an orthotopic model. Molecular cancer therapeutics 20071201
Tonic-clonic seizure as the presentation symptom of severe hypocalcemia secondary to zoledronic acid administration. Journal of palliative medicine 20071201
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Distribution and correlates of serum 25-hydroxyvitamin D levels in a sample of patients with hip fracture. The American journal of geriatric pharmacotherapy 20071201
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Consultation corner. Bone loss drug gives users a break. The Johns Hopkins medical letter health after 50 20071201
Paget disease of the spine manifested by thoracic and lumbar epidural lipomatosis: magnetic resonance imaging findings. Spine 20071201
Managing bone loss in women with early-stage breast cancer receiving aromatase inhibitors. Clinical breast cancer 20071201
New annual osteoporosis drug reduces risk of death, future fractures. Infused dose is more convenient for patients, enhances overall quality of life. DukeMedicine healthnews 20071201
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A once-yearly IV bisphosphonate for osteoporosis. The Medical letter on drugs and therapeutics 20071105
Serial markers of bone turnover in men with metastatic prostate cancer treated with zoledronic Acid for detection of bone metastases progression. European urology 20071101
Effects of bisphosphonate treatment on bone repair under immunosuppression using cyclosporine A in adult rats. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20071101
Zoledronic acid and secondary prevention of fractures. The New England journal of medicine 20071101
Zoledronate has an antitumor effect and induces actin rearrangement in dexamethasone-resistant myeloma cells. European journal of haematology 20071101
Treating bisphosphonate osteonecrosis of the jaws: is there a role for resection and vascularized reconstruction? Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20071101
Zoledronic acid for treatment of Paget's disease of bone. Expert opinion on pharmacotherapy 20071101
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[Advances in the field of osteoporosis]. La Revue du praticien 20071015
Decreases in pain at rest and movement-related pain during zoledronic acid treatment in patients with bone metastases due to breast or prostate cancer: a pilot study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20071001
Docetaxel, vinorelbine, and zoledronic acid as first-line treatment in patients with hormone refractory prostate cancer: a phase II study. European urology 20071001
New treatment strategies in the management of hormone refractory prostate cancer (HRPC): only chemotherapy? European urology 20071001
Biphosphonate-associated osteonecrosis can be controlled by nonsurgical management. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20071001
Re: 'A single zoleledronic acid infusion reduces bone resorption markers more rapidly than weekly oral alendronate in postmenopausal women with low bone mineral density' by Saag et al. Bone 20071001
Comparison of different intravenous bisphosphonate regimens for Paget's disease of bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20071001
Pharmacokinetics and pharmacodynamics of a single dose of zoledronate in healthy dogs. Journal of veterinary pharmacology and therapeutics 20071001
Is there a case for the early use of bisphosphonates in smouldering myeloma and MGUS? (Bisphosphonates in SMM & MGUS). International journal of laboratory hematology 20071001
Angiogenesis inhibitors and the need for anti-angiogenic therapeutics. Journal of dental research 20071001
The activity of zoledronic Acid on neuroblastoma bone metastasis involves inhibition of osteoclasts and tumor cell survival and proliferation. Cancer research 20071001
Paget disease manifesting with compressive sixth-nerve palsy that resolved with intravenous zoledronic acid therapy. Archives of ophthalmology (Chicago, Ill. : 1960) 20071001
Osteosarcoma cell line growth inhibition by zoledronate-stimulated effector cells. Cellular immunology 20071001
Prolonged efficacy of a single dose of the bisphosphonate zoledronic acid. Clinical cancer research : an official journal of the American Association for Cancer Research 20070915
Zoledronic acid-induced IPP/ApppI production in vivo. Life sciences 20070908
Cisplatin cytotoxicity is enhanced with zoledronic acid in A549 lung cancer cell line: preliminary results of an in vitro study. Cell biology international 20070901
Zoledronic acid efficacy and safety over five years in postmenopausal osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20070901
Acute phase response and mineral status following low dose intravenous zoledronic acid in children. Bone 20070901
Application of metabonomics in a comparative profiling study reveals N-acetylfelinine excretion as a biomarker for inhibition of the farnesyl pathway by bisphosphonates. Chemical research in toxicology 20070901
Leukocytoclastic vasculitis due to thalidomide in multiple myeloma. Japanese journal of clinical oncology 20070901
Spontaneous bilateral subcapital hip fracture due to multiple myeloma: an 18-month follow-up. European journal of cancer care 20070901
Osteonecrosis of the jaw as an adverse bisphosphonate event: three cases of bone metastatic prostate cancer patients treated with zoledronic acid. Medicina oral, patologia oral y cirugia bucal 20070901
Zoledronic acid and survival in breast cancer patients with bone metastases and elevated markers of osteoclast activity. The oncologist 20070901
Continuing benefit of zoledronic acid in preventing skeletal complications in patients with bone metastases. Clinical genitourinary cancer 20070901
Persistent hypocalcemia induced by zoledronic acid in a patient with androgen-independent prostate cancer and extensive bone metastases. Clinical genitourinary cancer 20070901
The clinical response on bone metastasis from breast and lung cancer during treatment with zoledronic acid is inversely correlated to skeletal related events (SRE). Journal of experimental & clinical cancer research : CR 20070901
Yearly zoledronic acid in postmenopausal osteoporosis. The New England journal of medicine 20070816
Yearly zoledronic acid in postmenopausal osteoporosis. The New England journal of medicine 20070816
Yearly zoledronic acid in postmenopausal osteoporosis. The New England journal of medicine 20070816
Yearly zoledronic acid in postmenopausal osteoporosis. The New England journal of medicine 20070816
Yearly zoledronic acid in postmenopausal osteoporosis. The New England journal of medicine 20070816
Chemotherapy and zoledronate sensitize solid tumour cells to Vgamma9Vdelta2 T cell cytotoxicity. Cancer immunology, immunotherapy : CII 20070801
Enhanced ability of dendritic cells to stimulate innate and adaptive immunity on short-term incubation with zoledronic acid. Blood 20070801
Focal segmental glomerulosclerosis associated with long-term treatment with zoledronate in a myeloma patient. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070801
Bone density in breast cancer: when to intervene? Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070801
Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells. International journal of oncology 20070801
Severe spontaneous cases of bisphosphonate-related osteonecrosis of the jaws. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20070801
Patient quality of life safeguarding: the primary aim in nonmetastatic prostate cancer patients. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070801
Repeated intermittent low-dose therapy with zoledronic acid induces an early, sustained, and long-lasting decrease of peripheral vascular endothelial growth factor levels in cancer patients. Clinical cancer research : an official journal of the American Association for Cancer Research 20070801
Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. Cancer research 20070801
Predictors of skeletal complications in men with hormone-refractory metastatic prostate cancer. Urology 20070801
Orofacial pain - a presenting symptom of bisphosphonate associated osteonecrosis of the jaws. British dental journal 20070728
Rates of myocardial infarction and coronary artery disease and risk factors in patients treated with radiation therapy for early-stage breast cancer. Cancer 20070715
Effects of skeletal morbidities on longitudinal patient-reported outcomes and survival in patients with metastatic prostate cancer. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20070701
A different schedule of zoledronic acid can reduce the risk of the osteonecrosis of the jaw in patients with multiple myeloma. Leukemia 20070701
Oral ibandronate is as active as intravenous zoledronic acid for reducing bone turnover markers in women with breast cancer and bone metastases. Annals of oncology : official journal of the European Society for Medical Oncology 20070701
Intravenous zoledronic acid 5 mg in the treatment of postmenopausal women with low bone density previously treated with alendronate. Bone 20070701
Bisphosphonates and osteonecrosis of the jaw. Rheumatology (Oxford, England) 20070701
Prophylactic bisphosphonate treatment prevents bone fractures after liver transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070701
New and emerging treatments for osteoporosis. Current opinion in rheumatology 20070701
Suppression of bone density loss and bone turnover in patients with hormone-sensitive prostate cancer and receiving zoledronic acid. BJU international 20070701
An audit to determine the time taken to administer intravenous bisphosphonate infusions in patients diagnosed with metastatic breast cancer to bone in a hospital setting. Current medical research and opinion 20070701
Receptor activator of NF-kappa B ligand inhibition suppresses bone resorption and hypercalcemia but does not affect host immune responses to influenza infection. Journal of immunology (Baltimore, Md. : 1950) 20070701
Lifestyle factors and duration of androgen deprivation affect bone mineral density of patients with prostate cancer during first year of therapy. Urology 20070701
By the way, doctor. Should I take an intravenous drug for osteoporosis? Harvard women's health watch 20070701
Efficacy and safety of intravenous bisphosphonates in patients with bone metastases caused by metastatic breast cancer. Clinical breast cancer 20070701
[Fracture prevention in postmenopausal women with osteoporosis by an annual infusion of zoledronic acid]. Nederlands tijdschrift voor geneeskunde 20070630
Growth inhibition and sensitization to cisplatin by zoledronic acid in osteosarcoma cells. Cancer letters 20070608
Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20070601
Dual inhibition of ras and bcr-abl signalling pathways in chronic myeloid leukaemia: a phase I/II study in patients in complete haematological remission. British journal of haematology 20070601
Bone turnover 18 months after a single intravenous dose of zoledronic acid. International journal of clinical practice 20070601
Articular damage is associated with intraosseous inflammation in the subchondral bone marrow of joints affected by experimental inflammatory arthritis and is modified by zoledronate treatment. The Journal of rheumatology 20070601
Therapeutic role of bisphosphonate and radiation combination in the management of myeloma bone disease. Clinical cancer research : an official journal of the American Association for Cancer Research 20070601
New developments of aminobisphosphonates: the double face of Janus. Annals of oncology : official journal of the European Society for Medical Oncology 20070601
[Mediastinal lymph nodes during the course of a metastatic prostate cancer]. Actas urologicas espanolas 20070601
Effect of zoledronic acid on the doxycycline-induced decrease in tumour burden in a bone metastasis model of human breast cancer. British journal of cancer 20070521
Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. The New England journal of medicine 20070503
Treatments for osteoporosis - looking beyond the HORIZON. The New England journal of medicine 20070503
Alendronate and atrial fibrillation. The New England journal of medicine 20070503
R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation. Journal of cellular physiology 20070501
Docetaxel and beyond. European urology 20070501
A single zoledronic acid infusion reduces bone resorption markers more rapidly than weekly oral alendronate in postmenopausal women with low bone mineral density. Bone 20070501
A single infusion of zoledronate prevents bone loss after stroke. Stroke 20070501
Treatment with zoledronic acid ameliorates negative geometric changes in the proximal femur following acute spinal cord injury. Calcified tissue international 20070501
Bisphosphonate treatment as a cause of jaw osteonecrosis. Oral diseases 20070501
The safety of zoledronic acid. Expert opinion on drug safety 20070501
Zoledronic acid prevents bone loss. The Lancet. Oncology 20070501
[Zoledronate-associated end stage renal failure and hypocalcaemia]. Praxis 20070425
Cytotoxic activity of the third-generation bisphosphonate zoledronic acid in acute myeloid leukemia. Leukemia research 20070401
Effect of zoledronic acid in an L6-L7 rabbit spine fusion model. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20070401
Annual zoledronate increases bone density in highly active antiretroviral therapy-treated human immunodeficiency virus-infected men: a randomized controlled trial. The Journal of clinical endocrinology and metabolism 20070401
Jaw osteonecrosis related to bisphosphonate therapy: a severe secondary disorder. Bone 20070401
Zoledronic acid inhibits the function of Toll-like receptor 4 ligand activated monocyte-derived dendritic cells. Leukemia 20070401
Re: Zoledronic acid initiated during the first year of androgen deprivation therapy increases bone mineral density in patients with prostate cancer: C. W. Ryan, D. Huo, L. M. Demers, T. M. Beer and L. V. Lacerna. J Urol 2006; 176: 972-978. The Journal of urology 20070401
Male breast cancer with mandibular metastasis. A case report. Minerva stomatologica 20070401
Comparative study of the protective effect of different intravenous bisphosphonates on the decrease in bone mineral density in patients submitted to radical prostatectomy undergoing androgen deprivation therapy. A prospective open-label controlled study. International journal of urology : official journal of the Japanese Urological Association 20070401
Zoledronic acid treatment at home: safety data from an observational prospective trial. Journal of palliative medicine 20070401
Potential effect of zoledronate therapy in heavy proteinuria. Clinical nephrology 20070401
Annual zoledronic acid: is less more? Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070320
Randomized controlled trial of annual zoledronic acid to prevent gonadotropin-releasing hormone agonist-induced bone loss in men with prostate cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070320
The effect of zoledronic acid incorporated in a poly(D,L-lactide) implant coating on osteoblasts in vitro. Journal of biomedical materials research. Part A 20070315
The risk of renal impairment in hormone-refractory prostate cancer patients with bone metastases treated with zoledronic acid. Cancer 20070315
Inhibitors of the mevalonate pathway as potential therapeutic agents in multiple myeloma. Leukemia research 20070301
Assessment of renal toxicity and osteonecrosis of the jaws in patients receiving zoledronic acid for bone metastasis. Annals of oncology : official journal of the European Society for Medical Oncology 20070301
Zoledronic acid inhibits adjuvant letrozole-induced bone loss in postmenopausal women with early breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070301
Zoledronic acid prevents cancer treatment-induced bone loss in premenopausal women receiving adjuvant endocrine therapy for hormone-responsive breast cancer: a report from the Austrian Breast and Colorectal Cancer Study Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070301
Bisphosphonate-associated osteonecrosis of the jaws: a therapeutic dilemma. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20070301
Use of intravenous bisphosphonates in osteoporosis. Current osteoporosis reports 20070301
Bisphosphonates and jaw osteonecrosis: the UAMS experience. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20070301
Paraplegia due to extramedullary hematopoiesis in thalassemia treated successfully with radiation therapy. Haematologica 20070301
The effect of zoledronic acid on bone mineral density in patients undergoing androgen deprivation therapy. Clinical genitourinary cancer 20070301
Clinical utility of biochemical markers of bone metabolism for improving the management of patients with advanced multiple myeloma. Clinical lymphoma & myeloma 20070301
Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase. Biochemical and biophysical research communications 20070223
Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis. Journal of the National Cancer Institute 20070221
Differential effects of bisphosphonates on breast cancer cell lines. Cancer letters 20070208
[Osteonecrosis of the jawbone as a side effect of intravenous treatment with bisphosphonates]. Nederlands tijdschrift voor geneeskunde 20070203
Treatment of avascular osteonecrosis of the mandible in cancer patients with a history of bisphosphonate therapy by combining bone resection and autologous platelet-rich plasma: Report of 3 cases. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20070201
Outcomes of patients with prostate cancer receiving zoledronic acid or pamidronate for prevention of skeletal-related events. Pharmacotherapy 20070201
Phase II trial of gemcitabine, prednisone, and zoledronic acid in pretreated patients with hormone refractory prostate cancer. Urology 20070201
Combined effects of a third-generation bisphosphonate, zoledronic acid with other anticancer agents against murine osteosarcoma. British journal of cancer 20070129
Enhancement of BCG-induced Th1 immune response through Vgamma9Vdelta2 T cell activation with non-peptidic drugs. Vaccine 20070122
Treatment of skeletal Erdheim-Chester disease with zoledronic acid: case report and proposed mechanisms of action. Rheumatology international 20070101
Effect of zoledronic acid on markers of bone turnover and mineral density in osteoporotic patients with beta-thalassaemia. Annals of hematology 20070101
A hitherto unreported high incidence of zoledronic acid-induced acute phase reaction in patients with cancer treatment-induced bone loss. Annals of oncology : official journal of the European Society for Medical Oncology 20070101
Long-term control of bone turnover in Paget's disease with zoledronic acid and risedronate. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20070101
Zoledronic acid activates the DNA S-phase checkpoint and induces osteosarcoma cell death characterized by apoptosis-inducing factor and endonuclease-G translocation independently of p53 and retinoblastoma status. Molecular pharmacology 20070101
Zoledronate inhibits endothelial cell adhesion, migration and survival through the suppression of multiple, prenylation-dependent signaling pathways. Journal of thrombosis and haemostasis : JTH 20070101
Bisphosphonate-associated osteonecrosis of the jaw in patients with multiple myeloma and breast cancer. Acta haematologica 20070101
Effect of zoledronic acid on metastatic hormone-refractory prostate cancer resistant to taxane, estramustine, carboplatin, and dexamethasone. International journal of urology : official journal of the Japanese Urological Association 20070101
[Therapeutic agents for disorders of bone and calcium metabolism: Zoledronic acid]. Clinical calcium 20070101
[Molecular mechanism and potential targets for bone metastasis]. Gan to kagaku ryoho. Cancer & chemotherapy 20070101
Morphoproteomic expression of H-ras (p21ras) correlates with serum monoclonal immunoglobulin reduction in multiple myeloma patients following pamidronate treatment. Annals of clinical and laboratory science 20070101
[Cost analysis of tumor-induced osteolysis treated with intravenous zoledronic acid and pamidronate: a time-motion study]. Recenti progressi in medicina 20070101
The effect of zoledronate on bone remodeling during the healing process. Acta cirurgica brasileira 20070101
Zoledronic acid: a review of its use in the treatment of Paget's disease of bone. Drugs 20070101
Clinical usefulness of bisphosphonates in oncology: treatment of bone metastases, antitumoral activity and effect on bone resorption markers. The International journal of biological markers 20070101
Oral bisphosphonate therapy and osteonecrosis of the jaw: what to tell the concerned patient. The International journal of prosthodontics 20070101
Zoledronic acid has direct antiproliferative and antimetastatic effect on pancreatic carcinoma cells and acts as an antigen for delta2 gamma/delta T cells. Journal of immunotherapy (Hagerstown, Md. : 1997) 20070101
Zoledronate inhibits alphavbeta3 and alphavbeta5 integrin cell surface expression in endothelial cells. Endothelium : journal of endothelial cell research 20070101
Osteonecrosis of the jaws due to bisphosphonate use. A review of 60 cases and treatment proposals. American journal of otolaryngology 20070101
Osteonecrosis of the jaw in prostate cancer patients with bone metastases treated with zoledronate: a retrospective analysis. Acta oncologica (Stockholm, Sweden) 20070101
The in vitro anti-tumour activity of zoledronic acid and docetaxel at clinically achievable concentrations in prostate cancer. Acta oncologica (Stockholm, Sweden) 20070101
Bisphosphonates and osteonecrosis of the jaw: a retrospective study. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20070101
Persistent effect of zoledronic acid in Paget's disease. Clinical and experimental rheumatology 20070101
Effect of zoledronic acid and an antibody against bone sialoprotein II on MDA-MB-231(GFP) breast cancer cells in vitro and on osteolytic lesions induced in vivo by this cell line in nude rats. Clinical & experimental metastasis 20070101
Zoledronic acid - a multiplicity of anti-cancer action. Current medicinal chemistry 20070101
Burden of bone disease. European journal of oncology nursing : the official journal of European Oncology Nursing Society 20070101
Role of the nurse in preserving patients' independence. European journal of oncology nursing : the official journal of European Oncology Nursing Society 20070101
Optimal management of metastatic bone disease. European journal of oncology nursing : the official journal of European Oncology Nursing Society 20070101
The role of nurses in preserving patients' functional independence: Zoledronic acid--evidence and experience in metastatic bone disease. European journal of oncology nursing : the official journal of European Oncology Nursing Society 20070101
Antitumor effect of zoledronic acid in previously untreated patients with multiple myeloma. Medical oncology (Northwood, London, England) 20070101
Zoledronic acid and clinical fractures and mortality after hip fracture. The New England journal of medicine 20070101
Complications & side effects. Zoledronic acid for thicker bones. TreatmentUpdate 20070101
Improvement of zoledronic-acid-induced jaw osteonecrosis with bortezomib. Acta haematologica 20070101
[Zoledronic acid free adjustment according to renal function: results of pharmacists interventions]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101
In vitro evaluation of zoledronic acid resistance developed in MCF-7 cells. Anticancer research 20070101
[Use of zoledromic acid on pain control in stages M1b of prostate cancer]. Actas urologicas espanolas 20070101
Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma. British journal of haematology 20061201
Osteonecrosis of the jaws in newly diagnosed multiple myeloma patients treated with zoledronic acid and thalidomide-dexamethasone. Blood 20061201
The effect of zoledronic acid on serum osteoprotegerin in early stage multiple myeloma. Haematologica 20061201
Jaw osteonecrosis associated with bisphosphonates. The New Zealand medical journal 20061201
Renal safety of 1-hour pamidronate infusion for breast cancer and multiple myeloma patients: comparison between clinical trials and population-based database. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20061201
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Anticancer effects of zoledronic acid against human osteosarcoma cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20060601
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First-line therapy with thalidomide, dexamethasone and zoledronic acid decreases bone resorption markers in patients with multiple myeloma. European journal of haematology 20060501
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Summaries for patients. Zolendronic acid prevents bone loss after liver transplantation. Annals of internal medicine 20060221
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[Two cases of stage IV breast cancer with severe hypercalcemia]. Gan to kagaku ryoho. Cancer & chemotherapy 20060201
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Weekly docetaxel and zoledronic acid every 4 weeks in hormone-refractory prostate cancer patients. Cancer chemotherapy and pharmacology 20060101
Two cases of endometrial cancer diagnosis associated with bone metastasis. Gynecologic and obstetric investigation 20060101
Local delivery of bisphosphonate from coated orthopedic implants increases implants mechanical stability in osteoporotic rats. Journal of biomedical materials research. Part A 20060101
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Osteonecrosis of the jaws and bisphosphonates. Report of three cases. Medicina oral, patologia oral y cirugia bucal 20060101
Rationale for zoledronic acid therapy in men with hormone-sensitive prostate cancer with or without bone metastasis. Urologic oncology 20060101
Administration of zoledronic acid enhances the effects of docetaxel on growth of prostate cancer in the bone environment. BMC cancer 20060101
A prospective randomized controlled clinical trial of zoledronic acid for bone metastases. The American journal of hospice & palliative care 20060101
Effects of zoledronic acid on proteinase plasma levels in patients with bone metastases. Anticancer research 20060101
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Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells. BMC cancer 20060101
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Mechanisms of the synergistic interaction between the bisphosphonate zoledronic acid and the chemotherapy agent paclitaxel in breast cancer cells in vitro. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20060101
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The effect of zoledronic acid and osteoprotegerin on growth of human lung cancer in the tibias of nude mice. Clinical & experimental metastasis 20060101
Additive/synergistic anti-tumoral effects of the combination of docetaxel and zoledronic acid on prostate cancer cells: possible mechanisms? Acta oncologica (Stockholm, Sweden) 20060101
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Randomized controlled clinical trial of a combination of somatostatin analog and dexamethasone plus zoledronate vs. zoledronate in patients with androgen ablation-refractory prostate cancer. Anticancer research 20060101
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A novel case of bisphosphonate-related osteonecrosis of the torus palatinus in a patient with metastatic breast cancer. Oncology 20060101
Consumer groups look to improve adverse event reporting systems. Journal of the National Cancer Institute 20051221
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The Otto Aufranc Award: bone augmentation around and within porous implants by local bisphosphonate elution. Clinical orthopaedics and related research 20051201
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By the way, doctor. I've heard that taking Fosamax for a long time causes the jawbone to deteriorate. Do you know anything about this? Harvard women's health watch 20051201
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RAS-blocking bisphosphonate zoledronic acid inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia cells in vitro. Blood 20051101
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Manipulation of the anabolic and catabolic responses with OP-1 and zoledronic acid in a rat critical defect model. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20051101
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Pilot studies of the effect of zoledronic acid (Zometa) on tumor-derived cells ex vivo in the ATP-based tumor chemosensitivity assay. Anti-cancer drugs 20051001
Bisphosphonate-associated osteonecrosis of the jaws and endodontic treatment: two case reports. Journal of endodontics 20051001
Bone microenvironment-related growth factors, zoledronic acid and dexamethasone differentially modulate PTHrP expression in PC-3 prostate cancer cells. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20051001
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Pagetic hydrocephalus treated with zoledronate. Annals of the rheumatic diseases 20050901
Gorham's disease of the mandible mimicking periodontal disease on radiograph. Journal of clinical periodontology 20050901
Treatment of Paget's disease--taming the wild osteoclast. The New England journal of medicine 20050901
Comparison of a single infusion of zoledronic acid with risedronate for Paget's disease. The New England journal of medicine 20050901
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Effects of zoledronate on markers of bone metabolism and subchondral bone mineral density in dogs with experimentally induced cruciate-deficient osteoarthritis. American journal of veterinary research 20050901
Important drug precaution for dental health professionals with patients being treated for cancer. Texas dental journal 20050901
Studies in osteonecrosis. British dental journal 20050827
Cytotoxic effects of gammadelta T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy. International journal of cancer 20050810
Little response to zoledronic acid in a child of juvenile myelomonocytic leukemia (JMML) harboring the PTPN11 mutation. Annals of oncology : official journal of the European Society for Medical Oncology 20050801
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Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050801
The effect of bisphosphonates and titanium particles on osteoblasts: an in vitro study. The Journal of bone and joint surgery. British volume 20050801
Zoledronate synergises with imatinib mesylate to inhibit Ph primary leukaemic cell growth. British journal of haematology 20050801
Cost-effectiveness of oral ibandronate versus IV zoledronic acid or IV pamidronate for bone metastases in patients receiving oral hormonal therapy for breast cancer in the United Kingdom. Clinical therapeutics 20050801
Evolving therapeutic role of bisphosphonates in multiple myeloma. British journal of cancer 20050725
Osteonecrosis of the jaw and bisphosphonates. The New England journal of medicine 20050707
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Enhanced tumor regression and tissue repair when zoledronic acid is combined with ifosfamide in rat osteosarcoma. Bone 20050701
Zoledronic acid down-regulates adhesion molecules of bone marrow stromal cells in multiple myeloma: a possible mechanism for its antitumor effect. Cancer 20050701
Bisphosphonates, as a new cause of drug-induced jaw osteonecrosis: an update. Medicina oral, patologia oral y cirugia bucal 20050701
Zoledronic acid improves femoral head sphericity in a rat model of perthes disease. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20050701
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Stimulation of bone formation by zoledronic acid in particle-induced osteolysis. Biomaterials 20050601
The bisphosphonate zoledronic acid inhibits the development of plasmacytoma induced in BALB/c mice by intraperitoneal injection of pristane. European journal of haematology 20050601
New therapeutic agents for the treatment of bone diseases. Expert opinion on biological therapy 20050601
Ask us: Some drugs affect tooth movement. American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 20050601
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[A comparison of the antiresorptive effects of bisphosphonates and statins on polyethylene particle-induced osteolysis]. Biomedizinische Technik. Biomedical engineering 20050601
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Zoledronic acid exerts its antitumor effect in multiple myeloma interfering with the bone marrow microenvironment. Hematology (Amsterdam, Netherlands) 20050601
Special precautions. British dental journal 20050528
Longer-lasting osteoporosis drugs sought. JAMA 20050525
Zoledronic acid significantly improves pain scores and quality of life in breast cancer patients with bone metastases: a randomised, crossover study of community vs hospital bisphosphonate administration. British journal of cancer 20050523
Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: a randomized, placebo-controlled trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050520
Profound hypocalcaemia after zoledronic acid treatment. The Medical journal of Australia 20050502
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Novel biomaterials for bisphosphonate delivery. Biomaterials 20050501
Bisphosphonates in breast cancer. Annals of oncology : official journal of the European Society for Medical Oncology 20050501
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The issue of renal safety of zoledronic acid from a nephrologist's point of view. The oncologist 20050501
'Safety and convenience of a 15-minute infusion of zoledronic acid': not so safe. The oncologist 20050501
Natural history of rising serum prostate-specific antigen in men with castrate nonmetastatic prostate cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050501
Modulation of bone microenvironment with zoledronate enhances the therapeutic effects of STI571 and paclitaxel against experimental bone metastasis of human prostate cancer. Cancer research 20050501
Bone-specific alkaline phosphatase activity is inhibited by bisphosphonates: role of divalent cations. Biological trace element research 20050501
Bisphosphonates, cancer, and osteonecrosis--a single practice experience. Delaware medical journal 20050501
Costs and consequences of using pamidronate compared with zoledronic acid in the management of breast cancer patients in the UK. Current medical research and opinion 20050501
Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors. Cancer 20050415
Effector gammadelta T cells and tumor cells as immune targets of zoledronic acid in multiple myeloma. Leukemia 20050401
[Rapid drug information]. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 20050401
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Management of bone metastases in breast cancer. Current treatment options in oncology 20050301
Osteonecrosis of the jaw associated with zoledronate therapy in a patient with multiple myeloma. British journal of haematology 20050301
Zoledronic acid-related angiogenesis modifications and survival in advanced breast cancer patients. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20050301
Phacilitate Cell and Gene Therapy Forum 2005. Cell and gene therapy: a corporate perspective. 24-26 January 2005, Washington, DC, USA. IDrugs : the investigational drugs journal 20050301
Zoledronic acid causes enhancement of bone growth into porous implants. The Journal of bone and joint surgery. British volume 20050301
Rapid prevention of vertebral fractures associated with osteoporosis. Orthopedics 20050301
[Multiple myeloma--recent advances in diagnosis and treatment]. Gan to kagaku ryoho. Cancer & chemotherapy 20050301
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Re: Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer. Journal of the National Cancer Institute 20050202
Bilateral acute uveitis and conjunctivitis after zoledronic acid therapy. Eye (London, England) 20050201
Short-term zoledronic acid treatment increases bone mineral density and marrow clonogenic fibroblast progenitors after allogeneic stem cell transplantation. The Journal of clinical endocrinology and metabolism 20050201
The role of bisphosphonates in hormone-refractory prostate cancer. World journal of urology 20050201
Synergistic cytotoxic effects of zoledronic acid and radiation in human prostate cancer and myeloma cell lines. International journal of radiation oncology, biology, physics 20050201
Economic evaluation of zoledronic acid versus pamidronate for the prevention of skeletal-related events in metastatic breast cancer and multiple myeloma. American journal of clinical oncology 20050201
Osteonecrosis of the maxilla in a patient with a history of bisphosphonate therapy. Journal (Canadian Dental Association) 20050201
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Optimizing bisphosphonate therapy in patients with breast cancer on endocrine therapy. Seminars in oncology 20041201
Breast tumour growth inhibition in vitro through the combination of cyclophosphamide/metotrexate/5-fluorouracil, epirubicin/cyclophosphamide, epirubicin/paclitaxel, and epirubicin/docetaxel with the bisphosphonates ibandronate and zoledronic acid. Oncology reports 20041101
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Combined chemotherapy and radiotherapy during conception and first two trimesters of gestation in a woman with metastatic breast cancer. Gynecologic oncology 20041001
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The effect of intravenous zoledronic acid on glucocorticoid-induced multiple vertebral fractures in juvenile systemic lupus erythematosus. Revista do Hospital das Clinicas 20041001
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Zoledronate-induced remission of acute panmyelosis with myelofibrosis. European journal of haematology 20040901
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An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. The Journal of clinical investigation 20040901
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Successful treatment of SAPHO syndrome with zoledronic acid. Arthritis and rheumatism 20040901
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In vitro toxicity of bisphosphonates on human neuroblastoma cell lines. Anti-cancer drugs 20040901
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Bisphosphonates induce apoptosis of stromal tumor cells in giant cell tumor of bone. Calcified tissue international 20040701
Prevention and management of osteoporosis in women with breast cancer and men with prostate cancer. Current oncology reports 20040701
Zoledronic acid induces apoptosis and inhibits adhesion to mineralized matrix in prostate cancer cells via inhibition of protein prenylation. BJU international 20040701
Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model. Clinical cancer research : an official journal of the American Association for Cancer Research 20040701
Bisphosphonates: environmental protection for the joint? Arthritis and rheumatism 20040701
Zoledronic acid protects against local and systemic bone loss in tumor necrosis factor-mediated arthritis. Arthritis and rheumatism 20040701
Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis. Arthritis and rheumatism 20040701
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Maintenance of increased bone mass after recombinant human parathyroid hormone (1-84) with sequential zoledronate treatment in ovariectomized rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040601
The HORIZON Recurrent Fracture Trial: design of a clinical trial in the prevention of subsequent fractures after low trauma hip fracture repair. Current medical research and opinion 20040601
Bone microenvironment-related growth factors modulate differentially the anticancer actions of zoledronic acid and doxorubicin on PC-3 prostate cancer cells. The Prostate 20040501
High-dose calcitriol, zoledronate, and dexamethasone for the treatment of progressive prostate carcinoma. Cancer 20040501
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Imatinib mesylate and zoledronic acid in androgen-independent prostate cancer. Urology 20040501
From labdanes to drimanes. Degradation of the side chain of dihydrozamoranic acid. Molecules (Basel, Switzerland) 20040430
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Treatment of beta-thalassaemia-associated osteoporosis with zoledronic acid. British journal of haematology 20040401
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Hypocalcemia and azotemia associated with zoledronic acid and interferon alfa. The Annals of pharmacotherapy 20040301
Nephrotoxicity of third-generation, intravenous bisphosphonates. Toxicology 20040301
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Heteromeric geranyl diphosphate synthase from mint: construction of a functional fusion protein and inhibition by bisphosphonate substrate analogs. Archives of biochemistry and biophysics 20040201
Health-related quality of life among patients with breast cancer receiving zoledronic acid or pamidronate disodium for metastatic bone lesions. Medical care 20040201
Dynamic contrast enhanced magnetic resonance imaging in monitoring bone metastases in breast cancer patients receiving bisphosphonates and endocrine therapy. Acta radiologica (Stockholm, Sweden : 1987) 20040201
Role of bisphosphonates in prostate cancer. European urology 20040101
Nonsustained effect of short-term bisphosphonate therapy on bone turnover three years after renal transplantation. Kidney international 20040101
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Hypercalcemia of malignancy. Seminars in nephrology 20040101
The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro. Bone 20040101
The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040101
Antiproliferative efficacy of the third-generation bisphosphonate, zoledronic acid, combined with other anticancer drugs in leukemic cell lines. International journal of hematology 20040101
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Management of androgen-independent prostate cancer. Cancer control : journal of the Moffitt Cancer Center 20040101
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The bisphosphonate zoledronic acid induces cytotoxicity in human myeloma cell lines with enhancing effects of dexamethasone and thalidomide. International journal of hematology 20031201
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Treatment strategies for myeloma bone disease. Oncology (Williston Park, N.Y.) 20031201
Bisphosphonates and avascular necrosis of the jaws. Australian dental journal 20031201
Low-dose thalidomide plus monthly high-dose oral dexamethasone (Thali-Dexa): results, prognostic factors and side effects in eight patients previously treated with multiple myeloma. Journal of experimental & clinical cancer research : CR 20031201
3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates. Journal of medicinal chemistry 20031120
Zoledronic acid treatment results in retention of femoral head structure after traumatic osteonecrosis in young Wistar rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20031101
Fever after zoledronic acid administration is due to increase in TNF-alpha and IL-6. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20031101
Bisphosphonate therapy in the oncology setting. Expert opinion on emerging drugs 20031101
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Renal failure with the use of zoledronic acid. The New England journal of medicine 20031023
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Thalidomide in newly diagnosed multiple myeloma and overview of experience in smoldering/indolent disease. Seminars in hematology 20031001
The renal effects of minimally nephrotoxic doses of ibandronate and zoledronate following single and intermittent intravenous administration in rats. Toxicology 20030930
The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate. Blood 20030915
Induction of gammadelta T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo. Blood 20030915
Bisphosphonates in prostate cancer: where are we and where should we go? Journal of the National Cancer Institute 20030903
Clinical trials test bisphosphonates in hormone-sensitive prostate cancer. Journal of the National Cancer Institute 20030903
A double-blind, placebo-controlled, randomized trial of oral sodium clodronate for metastatic prostate cancer (MRC PR05 Trial). Journal of the National Cancer Institute 20030903
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Zoledronic acid inhibits osteoclastogenesis in vitro and in a mouse model of inflammatory osteolysis. The Annals of otology, rhinology, and laryngology 20030901
Zoledronic acid versus placebo in the treatment of skeletal metastases in patients with lung cancer and other solid tumors: a phase III, double-blind, randomized trial--the Zoledronic Acid Lung Cancer and Other Solid Tumors Study Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030815
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Effect of the combination of docetaxel, zoledronic acid, and a COX-2 inhibitor on the growth of human breast cancer cell lines. American journal of clinical oncology 20030801
Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients. Clinical cancer research : an official journal of the American Association for Cancer Research 20030801
Zoledronic acid exhibits inhibitory effects on osteoblastic and osteolytic metastases of prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20030801
Cancer patients with bone complications prefer infusion of zoledronic acid. Oncology (Williston Park, N.Y.) 20030801
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Proven efficacy of zoledronic acid in the treatment of bone metastases in patients with breast cancer and other malignancies. Breast (Edinburgh, Scotland) 20030801
The anti-tumor potential of zoledronic acid. Breast (Edinburgh, Scotland) 20030801
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Injectable bisphosphonates in the treatment of postmenopausal osteoporosis. Aging clinical and experimental research 20030801
Toxic acute tubular necrosis following treatment with zoledronate (Zometa). Kidney international 20030701
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The use of bisphosphonates in prostate cancer. BJU international 20030701
How myeloma cells escape bisphosphonate-mediated killing: development of specific resistance with preserved sensitivity to conventional chemotherapeutics. British journal of haematology 20030701
Zoledronic acid prevents osteopenia and increases bone strength in a rabbit model of distraction osteogenesis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030701
Approval summary for zoledronic acid for treatment of multiple myeloma and cancer bone metastases. Clinical cancer research : an official journal of the American Association for Cancer Research 20030701
Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. British journal of cancer 20030616
Randomized controlled trial of zoledronic acid to prevent bone loss in men receiving androgen deprivation therapy for nonmetastatic prostate cancer. The Journal of urology 20030601
Highlights from the 98th annual meeting of the American Urological Association Chicago, IL. Clinical prostate cancer 20030601
New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects. British journal of cancer 20030519
Aetiology of bone disease and the role of bisphosphonates in multiple myeloma. The Lancet. Oncology 20030501
Selected therapy-related clinical research topics in osteoporosis. Journal of pediatric endocrinology & metabolism : JPEM 20030501
In focus: prostate cancer. Clinical advances in hematology & oncology : H&O 20030501
Long-term zoledronic acid treatment increases bone structure and mechanical strength of long bones of ovariectomized adult rats. Calcified tissue international 20030401
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Zoledronic acid: an advance in tumour bone disease therapy and a new hope for osteoporosis. Expert opinion on pharmacotherapy 20030401
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Zoledronate treatment in active Paget's disease. Annals of the rheumatic diseases 20030301
Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030301
Zoledronic acid to prevent bone loss in the first 6 months after renal transplantation. Kidney international 20030301
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The pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with varying degrees of renal function. Journal of clinical pharmacology 20030201
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Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain. Pain 20021201
Advances in the biology and treatment of myeloma bone disease. Seminars in oncology 20021201
Efficacy of bisphosphonates in the management of skeletal complications of bone metastases and selection of clinical endpoints. American journal of clinical oncology 20021201
Broad clinical activity of zoledronic acid in osteolytic to osteoblastic bone lesions in patients with a broad range of solid tumors. American journal of clinical oncology 20021201
Efficacy of zoledronic acid and pamidronate in breast cancer patients: a comparative analysis of randomized phase III trials. American journal of clinical oncology 20021201
Preclinical pharmacology of zoledronic acid. Seminars in oncology 20021201
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Treatment of bone complications in advanced prostate cancer: rationale for bisphosphonate use and results of a phase III trial with zoledronic acid. Seminars in oncology 20021201
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Zoledronic acid significantly reduces pathologic fractures in patients with advanced-stage prostate cancer metastatic to bone. Clinical prostate cancer 20021201
Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats. Cancer research 20021115
Development and validation of a highly sensitive RIA for zoledronic acid, a new potent heterocyclic bisphosphonate, in human serum, plasma and urine. Journal of pharmaceutical and biomedical analysis 20021107
Pamidronate causes apoptosis of plasma cells in vivo in patients with multiple myeloma. British journal of haematology 20021101
Severe increase in creatinine with hypocalcaemia in thalidomide-treated myeloma patients receiving zoledronic acid infusions. British journal of haematology 20021101
Pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with bone metastases. Journal of clinical pharmacology 20021101
A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma. Journal of the National Cancer Institute 20021002
The IL-6 receptor super-antagonist Sant7 enhances antiproliferative and apoptotic effects induced by dexamethasone and zoledronic acid on multiple myeloma cells. International journal of oncology 20021001
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The bisphosphonate zoledronic acid impairs Ras membrane [correction of impairs membrane] localisation and induces cytochrome c release in breast cancer cells. British journal of cancer 20020506
FDA approves ZOMETA for treatment of cancer-related bone complications. Expert review of anticancer therapy 20020401
Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts. Biochemical and biophysical research communications 20020301
The effect of bone remodeling inhibition by zoledronic acid in an animal model of cartilage matrix damage. Osteoarthritis and cartilage 20020301
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Bisphosphonate therapy in multiple myeloma: past, present, future. European journal of haematology 20020101
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