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163655-37-6 | 2H-Indol-2-one, 3-[[4-(dimethylamino)-1-naphthalenyl]methylene]-1,3-dihydro-
CAS No: 163655-37-6 Catalog No: AG001UAG MDL No:
Product Description
Catalog Number:
AG001UAG
Chemical Name:
2H-Indol-2-one, 3-[[4-(dimethylamino)-1-naphthalenyl]methylene]-1,3-dihydro-
CAS Number:
163655-37-6
Molecular Formula:
C21H18N2O
Molecular Weight:
314.3804
IUPAC Name:
3-[[4-(dimethylamino)naphthalen-1-yl]methylidene]-1H-indol-2-one
InChI:
InChI=1S/C21H18N2O/c1-23(2)20-12-11-14(15-7-3-4-9-17(15)20)13-18-16-8-5-6-10-19(16)22-21(18)24/h3-13H,1-2H3,(H,22,24)
InChI Key:
VFCXONOPGCDDBQ-UHFFFAOYSA-N
SMILES:
O=C1Nc2c(C1=Cc1ccc(c3c1cccc3)N(C)C)cccc2
Properties
Complexity:
512
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
314.142g/mol
Formal Charge:
0
Heavy Atom Count:
24
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
314.388g/mol
Monoisotopic Mass:
314.142g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
32.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
1
XLogP3:
4.3
Literature
| Title | Journal |
|---|---|
| Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells. | The American journal of pathology 20091001 |
| Lysophosphatidic acid up-regulates vascular endothelial growth factor-C and lymphatic marker expressions in human endothelial cells. | Cellular and molecular life sciences : CMLS 20080901 |
| VEGF-C promotes survival in podocytes. | American journal of physiology. Renal physiology 20060701 |
| MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo. | International journal of cancer 20041220 |
| Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. | European journal of biochemistry 20011101 |
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