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CAS No: 163042-96-4 Catalog No: AG001TN0 MDL No:MFCD01861178
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Resveratrol 3-O-D-glucuronide and resveratrol 4'-O-D-glucuronide inhibit colon cancer cell growth: evidence for a role of A3 adenosine receptors, cyclin D1 depletion, and G1 cell cycle arrest. | Molecular nutrition & food research 20131001 |
Adenosine A(3) receptor-induced proliferation of primary human coronary smooth muscle cells involving the induction of early growth response genes. | Journal of molecular and cellular cardiology 20121101 |
Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications. | Journal of medicinal chemistry 20120628 |
Anti-ischemic effects of multivalent dendrimeric A₃ adenosine receptor agonists in cultured cardiomyocytes and in the isolated rat heart. | Pharmacological research 20120301 |
3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists. | Journal of medicinal chemistry 20120223 |
P-glycoprotein mediates resistance to A3 adenosine receptor agonist 2-chloro-N6-(3-iodobenzyl)-adenosine-5'-n-methyluronamide in human leukemia cells. | Journal of cellular physiology 20120201 |
Protection from myocardial ischemia/reperfusion injury by a positive allosteric modulator of the A₃ adenosine receptor. | The Journal of pharmacology and experimental therapeutics 20120101 |
A3 adenosine receptor-mediated p53-dependent apoptosis in Lu-65 human lung cancer cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101 |
Adenosine induces apoptosis in SBC-3 human lung cancer cells through A(3) adenosine receptor-dependent AMID upregulation. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101 |
Adoptive immunotherapy with Cl-IB-MECA-treated CD8+ T cells reduces melanoma growth in mice. | PloS one 20120101 |
CF102 an A3 adenosine receptor agonist mediates anti-tumor and anti-inflammatory effects in the liver. | Journal of cellular physiology 20110901 |
Cl-IB-MECA enhances TNF-α release in peritoneal macrophages stimulated with LPS. | Cytokine 20110501 |
NK1.1 cells and CD8 T cells mediate the antitumor activity of Cl-IB-MECA in a mouse melanoma model. | Neoplasia (New York, N.Y.) 20110401 |
A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release. | Arthritis research & therapy 20110101 |
Adenosine receptor A3 is a critical mediator in LPS-induced pulmonary inflammation. | American journal of physiology. Lung cellular and molecular physiology 20101001 |
Control of enteric neuromuscular functions by purinergic A(3) receptors in normal rat distal colon and experimental bowel inflammation. | British journal of pharmacology 20101001 |
Adenosine A3 receptor agonist reduces early brain injury in subarachnoid haemorrhage. | Neuroreport 20100915 |
A(3) adenosine receptor activation during reperfusion reduces infarct size through actions on bone marrow-derived cells. | Journal of molecular and cellular cardiology 20100801 |
Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss. | Hearing research 20100201 |
The A3 adenosine receptor attenuates the calcium rise triggered by NMDA receptors in retinal ganglion cells. | Neurochemistry international 20100101 |
Nucleoside-derived antagonists to A3 adenosine receptors lower mouse intraocular pressure and act across species. | Experimental eye research 20100101 |
Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists. | Bioorganic & medicinal chemistry 20091201 |
Cl-IB-MECA enhances TRAIL-induced apoptosis via the modulation of NF-kappaB signalling pathway in thyroid cancer cells. | Journal of cellular physiology 20091101 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists. | Bioorganic & medicinal chemistry 20090515 |
Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor. | Journal of medicinal chemistry 20090409 |
Topological descriptors in modeling the agonistic activity of human A3 adenosine receptor ligands: the derivatives of 2-chloro-N(6)-substituted-4'-thioadenosine-5'-uronamide. | European journal of medicinal chemistry 20090401 |
Stimulation of ANP secretion by 2-Cl-IB-MECA through A(3) receptor and CaMKII. | Peptides 20081201 |
Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage. | European journal of pharmacology 20081031 |
Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists. | Journal of medicinal chemistry 20081023 |
Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system. | Bioorganic & medicinal chemistry 20080915 |
The A3 adenosine receptor agonist CF102 induces apoptosis of hepatocellular carcinoma via de-regulation of the Wnt and NF-kappaB signal transduction pathways. | International journal of oncology 20080801 |
Short- and long-term A3 adenosine receptor activation inhibits the Na+/H+ exchanger NHE3 activity and expression in opossum kidney cells. | Journal of cellular physiology 20080701 |
Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists. | Bioorganic & medicinal chemistry letters 20080501 |
Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists. | Journal of medicinal chemistry 20080327 |
Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists. | Bioorganic & medicinal chemistry letters 20080301 |
Cl-IB-MECA inhibits human thyroid cancer cell proliferation independently of A3 adenosine receptor activation. | Cancer biology & therapy 20080201 |
Dual purinergic synaptic transmission in the human enteric nervous system. | American journal of physiology. Gastrointestinal and liver physiology 20080201 |
Flexible modulation of agonist efficacy at the human A3 adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000. | BMC pharmacology 20080101 |
Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury. | American journal of physiology. Heart and circulatory physiology 20071201 |
Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta. | American journal of physiology. Heart and circulatory physiology 20071201 |
5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists. | Journal of medicinal chemistry 20071115 |
Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists. | Journal of medicinal chemistry 20070712 |
Barrier qualities of the mouse eye to topically applied drugs. | Experimental eye research 20070701 |
Adenosine receptors in colon carcinoma tissues and colon tumoral cell lines: focus on the A(3) adenosine subtype. | Journal of cellular physiology 20070601 |
The protective effect of prior ischemia reperfusion adenosine A1 or A3 receptor activation in the normal and hypertrophied heart. | Interactive cardiovascular and thoracic surgery 20070601 |
Cl-IB-MECA inhibits human erythropoiesis. | British journal of haematology 20070501 |
N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. | Journal of medicinal chemistry 20070322 |
Contractile effects of adenosine, coronary flow and perfusion pressure in murine myocardium. | Pflugers Archiv : European journal of physiology 20070101 |
Docking studies of agonists and antagonists suggest an activation pathway of the A3 adenosine receptor. | Journal of molecular graphics & modelling 20061201 |
Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor. | The Journal of pharmacology and experimental therapeutics 20061201 |
The impact of adenosine and A(2B) receptors on glucose homoeostasis. | The Journal of pharmacy and pharmacology 20061201 |
Identification of the A3 adenosine receptor in rat retinal ganglion cells. | Molecular vision 20060816 |
N6-ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists. | Bioorganic & medicinal chemistry letters 20060501 |
Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NF-kappaB activation in murine BV2 microglial cells. | Neuroscience letters 20060320 |
Adenosine receptors as therapeutic targets. | Nature reviews. Drug discovery 20060301 |
The role of adenosine A2A and A3 receptors on the differential modulation of norepinephrine and neuropeptide Y release from peripheral sympathetic nerve terminals. | Journal of neurochemistry 20060301 |
Antitumor effect of cordycepin (3'-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation. | Anticancer research 20060101 |
Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced toxicity in cortical cultured neurons. | Neurochemistry international 20051001 |
A3 adenosine receptor activation inhibits cell proliferation via phosphatidylinositol 3-kinase/Akt-dependent inhibition of the extracellular signal-regulated kinase 1/2 phosphorylation in A375 human melanoma cells. | The Journal of biological chemistry 20050520 |
(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists. | Journal of medicinal chemistry 20050324 |
The role of adenosine A2A and A2B receptors in the regulation of TNF-alpha production by human monocytes. | Biochemical pharmacology 20050315 |
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. | Journal of medicinal chemistry 20050310 |
Development of potent and selective human A3 adenosine receptor agonists. | Nucleic acids symposium series (2004) 20050101 |
Analysis of calcium responses mediated by the A3 adenosine receptor in cultured newborn rat cardiac myocytes. | Cell calcium 20041101 |
Activation of protein kinase B by adenosine A1 and A3 receptors in newborn rat cardiomyocytes. | Journal of molecular and cellular cardiology 20041101 |
Synthesis and biological evaluation of novel N6-[4-(substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 adenosine receptor agonists. | Journal of medicinal chemistry 20041021 |
Design and synthesis of 3'-ureidoadenosine-5'-uronamides: effects of the 3'-ureido group on binding to the A3 adenosine receptor. | Bioorganic & medicinal chemistry letters 20041004 |
2-Pyrazolyl-N(6)-substituted adenosine derivatives as high affinity and selective adenosine A(3) receptor agonists. | Journal of medicinal chemistry 20040909 |
Adenosine A3 receptor-induced CCL2 synthesis in cultured mouse astrocytes. | Glia 20040501 |
Role of adenosine receptor activation in antioxidant enzyme regulation during ischemia-reperfusion in the isolated rat heart. | Antioxidants & redox signaling 20040401 |
The A3 adenosine receptor agonist 2-Cl-IB-MECA facilitates epileptiform discharges in the CA3 area of immature rat hippocampal slices. | Epilepsy research 20040101 |
N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor. | Journal of medicinal chemistry 20030828 |
Functional expression of adenosine A2A and A3 receptors in the mouse dendritic cell line XS-106. | European journal of pharmacology 20030801 |
Characterization of adenosine receptor(s) involved in adenosine-induced bronchoconstriction in an allergic mouse model. | American journal of physiology. Lung cellular and molecular physiology 20030601 |
Design, synthesis and binding affinity of 3'-fluoro analogues of Cl-IB-MECA as adenosine A3 receptor ligands. | Bioorganic & medicinal chemistry letters 20030310 |
Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells. | Molecular pharmacology 20030201 |
3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor. | Journal of medicinal chemistry 20030130 |
Design and synthesis of A3 adenosine receptor ligands, 3'-fluoro analogues of Cl-IB-MECA. | Nucleosides, nucleotides & nucleic acids 20030101 |
Design and synthesis of A3 adenosine receptor ligands, 2'-fluoro analogues of Cl-IB-MECA. | Nucleosides, nucleotides & nucleic acids 20030101 |
A role for histamine in cytokine modulation by the adenosine A(3) receptor agonist, 2-Cl-IB-MECA. | European journal of pharmacology 20021213 |
Adenosine A(3) receptor activation protects the myocardium from reperfusion/reoxygenation injury. | American journal of physiology. Heart and circulatory physiology 20021001 |
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary. | Journal of medicinal chemistry 20020926 |
Targeted deletion of adenosine A(3) receptors augments adenosine-induced coronary flow in isolated mouse heart. | American journal of physiology. Heart and circulatory physiology 20020601 |
Differential aspects in ratio measurements of [Ca(2+)](i) relaxation in cardiomyocyte contraction following various drug treatments. | Cell calcium 20020601 |
p53-Independent induction of Fas and apoptosis in leukemic cells by an adenosine derivative, Cl-IB-MECA. | Biochemical pharmacology 20020301 |
Roles of BCL-2 and caspase 3 in the adenosine A3 receptor-induced apoptosis. | Journal of molecular neuroscience : MN 20011201 |
Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides. | Journal of medicinal chemistry 20011122 |
The A3 adenosine receptor as a new target for cancer therapy and chemoprotection. | Experimental cell research 20011001 |
Constitutive activation of A(3) adenosine receptors by site-directed mutagenesis. | Biochemical and biophysical research communications 20010615 |
Adenosine A(1) receptor-mediated inhibition of protein kinase A-induced calcitonin gene-related peptide release from rat trigeminal neurons. | Molecular pharmacology 20010601 |
Activation of A(3)adenosine receptor protects against doxorubicin-induced cardiotoxicity. | Journal of molecular and cellular cardiology 20010601 |
The A3 adenosine receptor induces cytoskeleton rearrangement in human astrocytoma cells via a specific action on Rho proteins. | Annals of the New York Academy of Sciences 20010601 |
A functional role for adenosine A3 receptors: modulation of synaptic plasticity in the rat hippocampus. | Neuroscience letters 20010413 |
Adenosine inhibits norepinephrine release in the postischemic rat heart: the mechanism of neuronal stunning. | Cardiovascular research 20010301 |
A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis. | Molecular pharmacology 20010101 |
Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes. | Molecular and cellular biochemistry 20010101 |
Induction of apoptosis in rat cardiocytes by A3 adenosine receptor activation and its suppression by isoproterenol. | Experimental cell research 20000525 |
Activation of the A3 adenosine receptor affects cell cycle progression and cell growth. | Naunyn-Schmiedeberg's archives of pharmacology 20000301 |
Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. | Journal of medicinal chemistry 19980813 |
Pharmacological characterization of novel A3 adenosine receptor-selective antagonists. | Neuropharmacology 19970901 |
2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors. | Journal of medicinal chemistry 19941014 |
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