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162641-16-9 | Piperidine, 4-(diphenylmethoxy)-1-[3-(2H-tetrazol-5-yl)propyl]-
CAS No: 162641-16-9 Catalog No: AG001TA3 MDL No:MFCD00936179
Product Description
Catalog Number:
AG001TA3
Chemical Name:
Piperidine, 4-(diphenylmethoxy)-1-[3-(2H-tetrazol-5-yl)propyl]-
CAS Number:
162641-16-9
Molecular Formula:
C22H27N5O
Molecular Weight:
377.4827
MDL Number:
MFCD00936179
IUPAC Name:
4-benzhydryloxy-1-[3-(2H-tetrazol-5-yl)propyl]piperidine
InChI:
InChI=1S/C22H27N5O/c1-3-8-18(9-4-1)22(19-10-5-2-6-11-19)28-20-13-16-27(17-14-20)15-7-12-21-23-25-26-24-21/h1-6,8-11,20,22H,7,12-17H2,(H,23,24,25,26)
InChI Key:
TZQGXAHOROZEKN-UHFFFAOYSA-N
SMILES:
c1ccc(cc1)C(c1ccccc1)OC1CCN(CC1)CCCc1n[nH]nn1
Properties
Complexity:
413
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
377.222g/mol
Formal Charge:
0
Heavy Atom Count:
28
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
377.492g/mol
Monoisotopic Mass:
377.222g/mol
Rotatable Bond Count:
8
Topological Polar Surface Area:
66.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.8
Literature
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|---|---|
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| Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2. | The Journal of pharmacology and experimental therapeutics 20111101 |
| [Hematopoietic prostaglandin D synthase inhibitors for the treatment of duchenne muscular dystrophy]. | Brain and nerve = Shinkei kenkyu no shinpo 20111101 |
| Selenium levels affect the IL-4-induced expression of alternative activation markers in murine macrophages. | The Journal of nutrition 20110901 |
| Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D2 synthase in macrophages is mediated through the activation of peroxisome proliferator-activated receptor (PPAR) gamma. | The Journal of biological chemistry 20110805 |
| Oesophagostomum dentatum: effect of glutathione S-transferase (GST) inhibitors on GST activity and larval development. | Experimental parasitology 20110401 |
| Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury. | Glia 20110401 |
| Prostaglandin D(2) synthesis in Oesophagostomum dentatum is mediated by cytosolic glutathione S-transferase. | Experimental parasitology 20110201 |
| Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment. | Journal of synchrotron radiation 20110101 |
| Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology. | Journal of ovarian research 20110101 |
| Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases. | Journal of medicinal chemistry 20100812 |
| Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase. | European journal of medicinal chemistry 20100201 |
| Protective role of hematopoietic prostaglandin D synthase in transient focal cerebral ischemia in mice. | Neuroscience 20090929 |
| Inhibition of prostaglandin D synthase suppresses muscular necrosis. | The American journal of pathology 20090501 |
| Prostaglandin H2 induces the migration of human eosinophils through the chemoattractant receptor homologous molecule of Th2 cells, CRTH2. | Journal of leukocyte biology 20090101 |
| [Structure and function of prostaglandin D synthase]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20080301 |
| Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. | The Journal of biological chemistry 20060602 |
| Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways. | Biochemical pharmacology 20060227 |
| Hematopoietic prostaglandin D synthase. | Prostaglandins, leukotrienes, and essential fatty acids 20030101 |
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