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Home > Imidazoles > 161973-10-0

161973-10-0

161973-10-0 | Magnesium, bis[6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl-κO]-1H-benzimidazolato-κN3]-, (T-4)-

CAS No: 161973-10-0 Catalog No: AG001SKP MDL No:MFCD06798050

Product Description

Catalog Number:
AG001SKP
Chemical Name:
Magnesium, bis[6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl-κO]-1H-benzimidazolato-κN3]-, (T-4)-
CAS Number:
161973-10-0
Molecular Formula:
C34H36MgN6O6S2
Molecular Weight:
713.1212
MDL Number:
MFCD06798050
IUPAC Name:
magnesium;5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
InChI:
InChI=1S/2C17H18N3O3S.Mg/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h2*5-8H,9H2,1-4H3;/q2*-1;+2
InChI Key:
KWORUUGOSLYAGD-UHFFFAOYSA-N
SMILES:
COc1ccc2c(c1)nc1n2[Mg-2]2([O+]=S1Cc1cc(C)c(c(n1)C)OC)[O+]=S(c1n2c2ccc(cc2n1)OC)Cc1ncc(c(c1C)OC)C

Properties

Complexity:
453  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
712.199g/mol
Formal Charge:
0
Heavy Atom Count:
49  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
713.123g/mol
Monoisotopic Mass:
712.199g/mol
Rotatable Bond Count:
10  
Topological Polar Surface Area:
163A^2
Undefined Atom Stereocenter Count:
2  
Undefined Bond Stereocenter Count:
0

Literature

Title Journal
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Phase I, multicenter, randomized, open-label study evaluating the pharmacokinetics and safety profile of repeated once-daily doses of intravenous esomeprazole in children 0 to 17 years of age. Clinical therapeutics 20120801
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Esomeprazole compared with famotidine in the prevention of upper gastrointestinal bleeding in patients with acute coronary syndrome or myocardial infarction. The American journal of gastroenterology 20120301
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A fixed-dose combination of naproxen and esomeprazole magnesium has comparable upper gastrointestinal tolerability to celecoxib in patients with osteoarthritis of the knee: results from two randomized, parallel-group, placebo-controlled trials. Annals of medicine 20111201
Randomized trial on 14 versus 7 days of esomeprazole, moxifloxacin, and amoxicillin for second-line or rescue treatment of Helicobacter pylori infection. Helicobacter 20111201
Impact of a fixed-dose combination of naproxen and esomeprazole magnesium on serum thromboxane B2 inhibition by low-dose aspirin over 5 days in healthy adults: a phase I, randomized, double-blind, placebo-controlled, noninferiority trial. Clinical therapeutics 20111201
Ventricular bigeminy associated with voriconazole, methadone and esomeprazole. International journal of clinical pharmacy 20111201
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Doubling the dose of clopidogrel restores the loss of antiplatelet effect induced by esomeprazole. Thrombosis research 20111101
The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: implications for coadministration with clopidogrel. Drug metabolism and disposition: the biological fate of chemicals 20111101
Effect of pH and comedication on gastrointestinal absorption of posaconazole: monitoring of intraluminal and plasma drug concentrations. Clinical pharmacokinetics 20111101
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[Esomeprazole-induced subacute cutaneous lupus erythematosus]. Actas dermo-sifiliograficas 20111001
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Randomised clinical trial: the burden of illness of uninvestigated dyspepsia before and after treatment with esomeprazole--results from the STARS II study. Alimentary pharmacology & therapeutics 20111001
Whole-cell oxidation of omeprazole sulfide to enantiopure esomeprazole with Lysinibacillus sp. B71. Bioresource technology 20110901
Randomized comparison of two nonbismuth-containing rescue therapies for Helicobacter pylori. The American journal of the medical sciences 20110901
Supplementation of Los Angeles classification with esophageal mucosa index of hemoglobin can predict the treatment response of erosive reflux esophagitis. Surgical endoscopy 20110801
Influence of esomeprazole on hypoglycemic activity of oral antidiabetic agents in rats and rabbits. Molecular and cellular biochemistry 20110801
Empirical modified sequential therapy containing levofloxacin and high-dose esomeprazole in second-line therapy for Helicobacter pylori infection: a multicentre clinical trial. The Journal of antimicrobial chemotherapy 20110801
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Randomized double-blind placebo-controlled crossover study to determine the effects of esomeprazole on inhibition of platelet function by clopidogrel. Journal of thrombosis and haemostasis : JTH 20110801
Reducing the risk of gastroduodenal ulcers with a fixed combination of esomeprazole and low-dose acetyl salicylic acid. Expert review of gastroenterology & hepatology 20110801
Treatment of non-erosive reflux disease with a proton pump inhibitor in Chinese patients: a randomized controlled trial. Journal of gastroenterology 20110701
Measurement of mucosal conductivity by MII is a potential marker of mucosal integrity restored in infants on acid-suppression therapy. Journal of pediatric gastroenterology and nutrition 20110701
Hypomagnesaemia/hypokalemia associated with the use of esomeprazole. Current drug safety 20110701
Impact of acid suppression on upper gastrointestinal pH and motility. Digestive diseases and sciences 20110601
Fixed-dose combination of enteric-coated naproxen and immediate-release esomeprazole has comparable efficacy to celecoxib for knee osteoarthritis: two randomized trials. Current medical research and opinion 20110601
Intravenous esomeprazole: a pharmacoeconomic profile of its use in the prevention of recurrent peptic ulcer bleeding. PharmacoEconomics 20110601
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Comparison of infusion or low-dose proton pump inhibitor treatments in upper gastrointestinal system bleeding. European journal of internal medicine 20110401
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Evaluation of bioequivalence between a single-capsule formulation of esomeprazole 40 mg and acetylsalicylic acid 325 mg and the monotherapies given separately in healthy volunteers. International journal of clinical pharmacology and therapeutics 20110201
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Evaluation of the pharmacokinetic interaction between lesogaberan (AZD3355) and esomeprazole in healthy subjects. Drugs in R&D 20101101
Racemization of the gastrointestinal antisecretory chiral drug esomeprazole magnesium via the pyramidal inversion mechanism: A theoretical study. Chirality 20101001
Comparison of the once-daily levofloxacin-containing triple therapy with the twice-daily standard triple therapy for first-line Helicobacter pylori eradication: a prospective randomised study. International journal of clinical practice 20101001
The effects of high-dose esomeprazole on gastric and oesophageal acid exposure and molecular markers in Barrett's oesophagus. Alimentary pharmacology & therapeutics 20101001
Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells. Cell death & disease 20101001
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Direct HPLC enantioseparation of omeprazole and its chiral impurities: application to the determination of enantiomeric purity of esomeprazole magnesium trihydrate. Journal of pharmaceutical and biomedical analysis 20100905
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E3710, a new proton pump inhibitor, with a long-lasting inhibitory effect on gastric acid secretion. The Journal of pharmacology and experimental therapeutics 20100801
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Clinical trial: the incidence of NSAID-associated endoscopic gastric ulcers in patients treated with PN 400 (naproxen plus esomeprazole magnesium) vs. enteric-coated naproxen alone. Alimentary pharmacology & therapeutics 20100801
A model of healing of Los Angeles grades C and D reflux oesophagitis: is there an optimal time of acid suppression for maximal healing? Alimentary pharmacology & therapeutics 20100801
Effect of the proton pump inhibitor esomeprazole on the oral absorption and pharmacokinetics of nilotinib. Journal of clinical pharmacology 20100801
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pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity. International journal of cancer 20100701
Esomeprazole-induced rhabdomyolysis in a patient with heart failure. Intensive care medicine 20100701
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Clinical trial: gastric acid suppression in Hispanic adults with symptomatic gastro-oesophageal reflux disease - comparator study of esomeprazole, lansoprazole and pantoprazole. Alimentary pharmacology & therapeutics 20100701
Clinical trial: esomeprazole for moderate-to-severe nighttime heartburn and gastro-oesophageal reflux disease-related sleep disturbances. Alimentary pharmacology & therapeutics 20100701
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Effect of esomeprazole 40 mg once or twice daily on asthma: a randomized, placebo-controlled study. American journal of respiratory and critical care medicine 20100515
Comparison of esomeprazole to aerosolized, swallowed fluticasone for eosinophilic esophagitis. Digestive diseases and sciences 20100501
Long-term outcome of microscopic esophagitis in chronic GERD patients treated with esomeprazole or laparoscopic antireflux surgery in the LOTUS trial. The American journal of gastroenterology 20100501
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Ten and eight-day sequential therapy in comparison to standard triple therapy for eradicating Helicobacter pylori infection: a randomized controlled study on efficacy and tolerability. Journal of clinical gastroenterology 20100401
Possible acute thrombocytopenia post esomeprazole and hydantoin coadministration. Journal of pharmacy practice 20100401
Factors influencing intercellular spaces in the rat esophageal epithelium. World journal of gastroenterology 20100307
The pharmacodynamics and pharmacokinetics of S-tenatoprazole-Na 30 mg, 60 mg and 90 mg vs. esomeprazole 40 mg in healthy male subjects. Alimentary pharmacology & therapeutics 20100301
Recurrence of acute myocardial infarction in patients discharged on clopidogrel and a proton pump inhibitor after stent placement for acute myocardial infarction. Clinical cardiology 20100301
Counselling by primary care physicians may help patients with heartburn-predominant uninvestigated dyspepsia. Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20100301
The effect of esomeprazole 20 mg twice daily on acoustic and perception parameters of the voice in laryngopharyngeal reflux. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100201
Efficacy of three different dosages of esomeprazole in the long-term management of reflux disease: a prospective, randomized study, using the wireless Bravo pH system. The American journal of gastroenterology 20100201
Efficacy of four different moxifloxacin-based triple therapies for first-line H. pylori treatment. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20100201
Delayed release film coating applications on oral solid dosage forms of proton pump inhibitors: case studies. Drug development and industrial pharmacy 20100201
Bismuth-containing quadruple therapy as second-line treatment for Helicobacter pylori infection: effect of treatment duration and antibiotic resistance on the eradication rate in Korea. Helicobacter 20100201
A comparison of the acid-inhibitory effects of esomeprazole and pantoprazole in relation to pharmacokinetics and CYP2C19 polymorphism. Alimentary pharmacology & therapeutics 20100101
Oral buffered esomeprazole is superior to i.v. pantoprazole for rapid rise of intragastric pH: a wireless pH metry analysis. Journal of gastroenterology and hepatology 20100101
Cost effectiveness of high-dose intravenous esomeprazole for peptic ulcer bleeding. PharmacoEconomics 20100101
Esophageal hematoma mimicking downhill varices: resolution after esomeprazole therapy. Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates 20100101
Esomeprazole for the treatment of erosive esophagitis in children: an international, multicenter, randomized, parallel-group, double-blind (for dose) study. BMC pediatrics 20100101
Early marginal ulcer following Roux-en-Y gastric bypass under proton pump inhibitor treatment: prospective multicentric study. Arquivos de gastroenterologia 20100101
Esomeprazole-induced photoallergic dermatitis. Journal of postgraduate medicine 20100101
Effects of multiple-dose esomeprazole and pantoprazole on diazepam pharmacokinetic profile and pharmacodynamic effects on cognitive and psychomotor function in healthy volunteers. Arzneimittel-Forschung 20100101
Differential effects of esomeprazole on the antiplatelet activity of clopidogrel in healthy individuals and patients after coronary stent implantation. The Journal of international medical research 20100101
Clarithromycin-amoxycillin-containing triple therapy: a valid empirical first-line treatment for Helicobacter pylori eradication in Hong Kong? Helicobacter 20091201
A single dose of intravenous esomeprazole decreases gastric secretion in healthy volunteers. Alimentary pharmacology & therapeutics 20091115
[Effect of esomeprazole upon intestinal mucosal damage following traumatic brain injury in rats]. Zhonghua yi xue za zhi 20091103
Quantification of dental erosions in patients with GERD using optical coherence tomography before and after double-blind, randomized treatment with esomeprazole or placebo. The American journal of gastroenterology 20091101
Effects of asymptomatic proximal and distal gastroesophageal reflux on asthma severity. American journal of respiratory and critical care medicine 20091101
Moxifloxacin-containing triple therapy as second-line treatment for Helicobacter pylori infection: effect of treatment duration and antibiotic resistance on the eradication rate. Helicobacter 20091001
Systematic review: standard- and double-dose proton pump inhibitors for the healing of severe erosive oesophagitis -- a mixed treatment comparison of randomized controlled trials. Alimentary pharmacology & therapeutics 20090915
Furazolidone, co-amoxiclav, colloidal bismuth subcitrate, and esomeprazole for patients who failed to eradicate Helicobacter pylori with triple therapy. Digestive diseases and sciences 20090901
Seven-day intravenous low-dose omeprazole infusion reduces peptic ulcer rebleeding for patients with comorbidities. Gastrointestinal endoscopy 20090901
Predictors of heartburn resolution and erosive esophagitis in patients with GERD. Current medical research and opinion 20090901
The pharmacology of esomeprazole and its role in gastric acid related diseases. Expert opinion on drug metabolism & toxicology 20090901
Evaluation of the pharmacokinetic interaction between esomeprazole (40 mg) and acetylsalicylic acid (325 mg) in healthy volunteers. International journal of clinical pharmacology and therapeutics 20090901
Subcutaneous infusion of esomeprazole in elderly patients in palliative care: a report of two cases. Journal of the American Geriatrics Society 20090901
Off-label use of medicines in children: can available evidence avoid useless paediatric trials? The case of proton pump inhibitors for the treatment of gastroesophageal reflux disease. European journal of clinical pharmacology 20090801
Pharmacodynamics and systemic exposure of esomeprazole in preterm infants and term neonates with gastroesophageal reflux disease. The Journal of pediatrics 20090801
Esomeprazole for asthma. The New England journal of medicine 20090709
Esomeprazole for asthma. The New England journal of medicine 20090709
Esomeprazole for asthma. The New England journal of medicine 20090709
Second-line levofloxacin-based triple schemes for Helicobacter pylori eradication. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20090701
Transmucosal gastric leak induced by proton pump inhibitors. Digestive diseases and sciences 20090701
Microscopic colitis associated with omeprazole and esomeprazole exposure. Journal of clinical gastroenterology 20090701
Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy. Gastroenterology 20090701
H. pylori eradication prevents the progression of gastric intestinal metaplasia in reflux esophagitis patients using long-term esomeprazole. The American journal of gastroenterology 20090701
Clinical trial: intragastric acid control in patients who have Barrett's oesophagus--comparison of once- and twice-daily regimens of esomeprazole and lansoprazole. Alimentary pharmacology & therapeutics 20090701
Clinical course of laryngo-respiratory symptoms in gastro-oesophageal reflux disease during routine care--a 5-year follow-up. Alimentary pharmacology & therapeutics 20090601
Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20090601
Clinical trial: factors associated with freedom from relapse of heartburn in patients with healed reflux oesophagitis--results from the maintenance phase of the EXPO study. Alimentary pharmacology & therapeutics 20090601
Clinical trial: the treatment of gastro-oesophageal reflux disease in primary care--prospective randomized comparison of rabeprazole 20 mg with esomeprazole 20 and 40 mg. Alimentary pharmacology & therapeutics 20090501
Clinical trial: factors associated with resolution of heartburn in patients with reflux oesophagitis--results from the EXPO study. Alimentary pharmacology & therapeutics 20090501
Efficacy of levofloxacin-based rescue therapy for Helicobacter pylori infection after standard triple therapy: a randomized controlled trial. The Journal of antimicrobial chemotherapy 20090501
Hypomagnesaemia due to use of proton pump inhibitors--a review. The Netherlands journal of medicine 20090501
Effect of proton pump inhibition on the gastric volume: assessed by magnetic resonance imaging. Alimentary pharmacology & therapeutics 20090415
Efficacy of esomeprazole for treatment of poorly controlled asthma. The New England journal of medicine 20090409
Intravenous esomeprazole for prevention of recurrent peptic ulcer bleeding: a randomized trial. Annals of internal medicine 20090407
Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel. Thrombosis and haemostasis 20090401
Is body mass index really the most important factor determining the healing of reflux esophagitis by esomeprazole? The American journal of gastroenterology 20090301
Seven-day PPI-triple therapy with levofloxacin is very effective for Helicobacter pylori eradication. The Netherlands journal of medicine 20090301
Oral or intravenous proton pump inhibitor in patients with peptic ulcer bleeding after successful endoscopic epinephrine injection. British journal of clinical pharmacology 20090301
Comparative study of omeprazole, lansoprazole, pantoprazole and esomeprazole for symptom relief in patients with reflux esophagitis. World journal of gastroenterology 20090227
Nefopam hydrochloride compatibility and stability with selected proton pump inhibitors in bionolyte G5 injection for intravenous infusion. Journal of clinical pharmacy and therapeutics 20090201
Esomeprazole: a proton pump inhibitor. Expert review of gastroenterology & hepatology 20090201
After move to tier 3, Nexium scripts fall 25%. Managed care (Langhorne, Pa.) 20090201
Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats. Regulatory peptides 20090108
A randomized, open trial evaluating the effect of Saccharomyces boulardii on the eradication rate of Helicobacter pylori infection in children. Acta paediatrica (Oslo, Norway : 1992) 20090101
Optimal dose regimens of esomeprazole for gastric acid suppression with minimal influence of the CYP2C19 polymorphism. European journal of clinical pharmacology 20090101
Cost analysis of long-term treatment of patients with symptomatic gastroesophageal reflux disease (GERD) with esomeprazole on-demand treatment or esomeprazole continuous treatment: an open, randomized, multicenter study in Switzerland. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20090101
Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel. American heart journal 20090101
The Australian rise of esomeprazole-was expenditure on samples a contributor? Pharmacoepidemiology and drug safety 20090101
Proton-pump inhibitor utilization associated with the change to nonpreferred formulary status for esomeprazole in the TRICARE formulary. Journal of managed care pharmacy : JMCP 20090101
Chemoprevention of oesophageal cancer and the AspECT trial. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20090101
Alternative vs. conventional treatment given on-demand for gastroesophageal reflux disease: a randomised controlled trial. BMC complementary and alternative medicine 20090101
[Stevens-Johnson syndrome and toxic hepatitis due to esomeprazole]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20090101
Improving quality of magnetic resonance cholangiopancreaticography: esomeprazole versus ranitidine. Hepato-gastroenterology 20090101
High-dose esomeprazole for treatment of symptomatic refractory gastroesophageal reflux disease--a prospective pH-metry/impedance-controlled study. Digestion 20090101
Esomeprazole for the management of upper gastrointestinal symptoms in patients who require NSAIDs: a review of the NASA and SPACE double-blind, placebo-controlled studies. Clinical drug investigation 20090101
Patient satisfaction with switching to esomeprazole from existing proton pump inhibitor therapy for gastro-oesophageal reflux disease: an observational, multicentre study. Clinical drug investigation 20090101
[Esomeprazole based triple therapy for the eradication of helicobacter pylori in patients with non-ulcer dyspepsia]. Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru 20090101
Effects of esomeprazole treatment for gastroesophageal reflux disease on quality of life in 12- to 17-year-old adolescents: an international health outcomes study. BMC gastroenterology 20090101
[Omeprazol and ezomeprazol pharmacokinetics, duration of antisecretory effect, and reasons for their probable changes in duodenal ulcer]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20090101
Peptic ulcer bleeding following therapeutic endoscopy: a new indication for intravenous esomeprazole. Reviews in gastroenterological disorders 20090101
[Usage of Nexium (ezomeprazole) at children with acid depended inflammatory diseases of upper gastrointestinal tract]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20090101
[Comparative study of esomeprazole and omeprazole using for initialism therapy for elderly-senile and young-adulthood patients with GERD]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20090101
Moxifloxacine plus amoxicillin and ranitidine bismuth citrate or esomeprazole triple therapies for Helicobacter pylori infection. Digestive diseases and sciences 20081201
A glass of water immediately increases gastric pH in healthy subjects. Digestive diseases and sciences 20081201
Esomeprazole induces upper gastrointestinal tract transmucosal permeability increase. Alimentary pharmacology & therapeutics 20081201
Effect of CYP2C19 genetic polymorphisms on the efficacy of proton pump inhibitor-based triple therapy for Helicobacter pylori eradication: a meta-analysis. Helicobacter 20081201
The effectiveness of esomeprazole 40 mg in patients with persistent symptoms of gastro-oesophageal reflux disease following treatment with a full dose proton pump inhibitor. International journal of clinical practice 20081201
[Chronic use of proton-pump inhibitors associated with giardiasis: A rare cause of hypomagnesemic hypoparathyroidism?]. Annales d'endocrinologie 20081101
Bravo capsule system optimizes intragastric pH monitoring over prolonged time: effects of ghrelin on gastric acid and hormone secretion in the rat. World journal of gastroenterology 20081028
[General practitioners' management of gastroesophageal reflux in France in 2005: a pharmacoeconomic study]. Presse medicale (Paris, France : 1983) 20081001
Effects of esomeprazole on glutathione levels and mitochondrial oxidative phosphorylation in the gastric mucosa of rats treated with indomethacin. Naunyn-Schmiedeberg's archives of pharmacology 20081001
Efficacy of esomeprazole (20 mg once daily) for reducing the risk of gastroduodenal ulcers associated with continuous use of low-dose aspirin. The American journal of gastroenterology 20081001
Meta-analysis: high-dose proton pump inhibitors vs. standard dose in triple therapy for Helicobacter pylori eradication. Alimentary pharmacology & therapeutics 20081001
Medical or surgical management of GERD patients with Barrett's esophagus: the LOTUS trial 3-year experience. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20081001
Comparing laparoscopic antireflux surgery with esomeprazole in the management of patients with chronic gastro-oesophageal reflux disease: a 3-year interim analysis of the LOTUS trial. Gut 20080901
Physical and chemical stability of esomeprazole sodium solutions. The Annals of pharmacotherapy 20080901
Body mass index can determine the healing of reflux esophagitis with Los Angeles Grades C and D by esomeprazole. The American journal of gastroenterology 20080901
Double-blind, placebo-controlled trial with esomeprazole for symptoms and signs associated with laryngopharyngeal reflux. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20080901
Preparation of esomeprazole zinc solid dispersion and study on its pharmacokinetics. International journal of pharmaceutics 20080806
Effect of the CYP2C19 polymorphism on the eradication rate of Helicobacter pylori infection by 7-day triple therapy with regular proton pump inhibitor dosage. Journal of gastroenterology and hepatology 20080801
[Comparison of Helicobacter pylori eradication rate in patients with non-ulcer dyspepsia and peptic ulcer diseases according to proton pump inhibitors]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20080801
Predictable prolonged suppression of gastric acidity with a novel proton pump inhibitor, AGN 201904-Z. Alimentary pharmacology & therapeutics 20080701
Changes in gene expression of gastric mucosa during therapeutic acid inhibition. European journal of gastroenterology & hepatology 20080701
[Preparation and dissolution in vitro of esomeprazole zinc solid dispersion]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080701
Effect of esomeprazole triple therapy on eradication rates of Helicobacter pylori, gastric ulcer healing and prevention of relapse in gastric ulcer patients. European journal of gastroenterology & hepatology 20080601
Esomeprazole in acute and maintenance treatment of reflux oesophagitis: a multicentre prospective study. Advances in therapy 20080601
[Diagnosis of gastroesophageal reflux disease-related noncardiac chest pain]. Zhonghua yi xue za zhi 20080527
The effect of famotidine, esomeprazole, and ezetimibe on levothyroxine absorption. Thyroid : official journal of the American Thyroid Association 20080501
FDA approves nexium for use in children ages 1-11 years. Gastroenterology 20080501
Safety and tolerability of esomeprazole in children with gastroesophageal reflux disease. Journal of pediatric gastroenterology and nutrition 20080501
Preoperative administration of esomeprazole has no influence on frequency of refluxes. Journal of clinical anesthesia 20080501
Intravenous esomeprazole for prevention of peptic ulcer re-bleeding: rationale/design of Peptic Ulcer Bleed study. Alimentary pharmacology & therapeutics 20080401
Correlation between oesophageal acid exposure and dyspeptic symptoms in patients with nonerosive reflux disease. European journal of gastroenterology & hepatology 20080401
Comparison of esomeprazole enteric-coated capsules vs esomeprazole magnesium in the treatment of active duodenal ulcer: a randomized, double-blind, controlled study. World journal of gastroenterology 20080328
Intravenous esomeprazole 40 mg vs. intravenous lansoprazole 30 mg for controlling intragastric acidity in healthy adults. Alimentary pharmacology & therapeutics 20080315
The anti-secretory and anti-ulcer activities of esomeprazole in comparison with omeprazole in the stomach of rats and rabbits. Molecular and cellular biochemistry 20080201
One-week once-daily triple therapy with esomeprazole, moxifloxacin, and rifabutin for eradication of persistent Helicobacter pylori resistant to both metronidazole and clarithromycin. Helicobacter 20080201
In-practice predictors of response to proton pump inhibitor therapy in primary care patients with dyspepsia in an Asian population. Journal of clinical gastroenterology 20080201
Management strategy for patients with gastroesophageal reflux disease: a comparison between empirical treatment with esomeprazole and endoscopy-oriented treatment. The American journal of gastroenterology 20080201
A randomized, comparative trial of a potassium-competitive acid blocker (AZD0865) and esomeprazole for the treatment of patients with nonerosive reflux disease. The American journal of gastroenterology 20080101
Validation of a four-graded scale for severity of heartburn in patients with symptoms of gastroesophageal reflux disease. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20080101
Clinical efficacy of esomeprazole in the prevention and healing of gastrointestinal toxicity associated with NSAIDs in elderly patients. Drugs & aging 20080101
Effect of proton-pump inhibitor treatment on symptoms and quality of life in GERD patients depends on the symptom-reflux association. Journal of clinical gastroenterology 20080101
Safety profile of esomeprazole: results of a prescription-event monitoring study of 11 595 patients in England. Drug safety 20080101
Stereoselective disposition of proton pump inhibitors. Clinical drug investigation 20080101
Esomeprazole: in gastroesophageal reflux disease in children and adolescents. Paediatric drugs 20080101
Effect of increasing esomeprazole and pantoprazole doses on acid control in patients with symptoms of gastro-oesophageal reflux disease: a randomized, dose-response study. Clinical drug investigation 20080101
Occurrence of community-acquired respiratory tract infection in patients receiving esomeprazole: retrospective analysis of adverse events in 31 clinical trials. Drug safety 20080101
Esomeprazole: a review of its use in the management of gastric acid-related diseases in adults. Drugs 20080101
Effect of acid suppression on gastric myoelectrical activity in GERD. Hepato-gastroenterology 20080101
Esomeprazole reduces gastroesophageal reflux after beer consumption in healthy volunteers. Scandinavian journal of gastroenterology 20080101
Effect of proton pump inhibitors on gastric juice volume, gastric pH and gastric intramucosal pH in critically ill patients : a randomized, double-blind, placebo-controlled study. Clinical drug investigation 20080101
The effect of acid suppression on sleep and cardiac autonomic regulation in GERD. Hepato-gastroenterology 20080101
Esomeprazole prevents aspirin-induced ulcers. Medscape journal of medicine 20080101
Effects of esomeprazole on acid output in patients with Zollinger-Ellison syndrome or idiopathic gastric acid hypersecretion. The American journal of gastroenterology 20071201
Water load test before and after PPI therapy in patients with gastro-oesophageal reflux disease. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20071201
A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20071201
Second-line treatment for Helicobacter pylori infection: 10-day moxifloxacin-based triple therapy versus 2-week quadruple therapy. Helicobacter 20071201
Rabeprazole- versus esomeprazole-based eradication regimens for H. pylori infection. Helicobacter 20071201
Double-dose, new-generation proton pump inhibitors do not improve Helicobacter pylori eradication rate. Helicobacter 20071201
Esomeprazole-induced DRESS syndrome. Studies of cross-reactivity among proton-pump inhibitor drugs. Allergy 20071101
The impact of body mass index on the application of on-demand therapy for Los Angeles grades A and B reflux esophagitis. The American journal of gastroenterology 20071101
Safety and symptom improvement with esomeprazole in adolescents with gastroesophageal reflux disease. Journal of pediatric gastroenterology and nutrition 20071101
Pharmacokinetics and acid-suppressive effects of esomeprazole in infants 1-24 months old with symptoms of gastroesophageal reflux disease. Journal of pediatric gastroenterology and nutrition 20071101
Impact of treatment of gastroesophageal reflux on obstructive sleep apnea-hypopnea syndrome. The Annals of otology, rhinology, and laryngology 20071101
Clinical trial: healing of NSAID-associated gastric ulcers in patients continuing NSAID therapy - a randomized study comparing ranitidine with esomeprazole. Alimentary pharmacology & therapeutics 20071015
[Repeated dual-probe pH monitoring as a diagnostic tool to control therapy for laryngopharyngeal reflux]. HNO 20071001
Clinical trial: levofloxacin-based quadruple therapy was inferior to traditional quadruple therapy in the treatment of resistant Helicobacter pylori infection. Alimentary pharmacology & therapeutics 20071001
Effect of timing of dosing in relation to food intake on the pharmacokinetics of esomeprazole. British journal of clinical pharmacology 20070901
High-dose versus low-dose esomeprazole-based triple therapy for Helicobacter pylori infection. European journal of clinical investigation 20070901
One-week acid suppression trial in uninvestigated dyspepsia patients with epigastric pain or burning to predict response to 8 weeks' treatment with esomeprazole: a randomized, placebo-controlled study. Alimentary pharmacology & therapeutics 20070901
Randomized-controlled trial of esomeprazole in functional dyspepsia patients with epigastric pain or burning: does a 1-week trial of acid suppression predict symptom response? Alimentary pharmacology & therapeutics 20070901
Distension during gastroesophageal reflux: effects of acid inhibition and correlation with symptoms. American journal of physiology. Gastrointestinal and liver physiology 20070801
Recent advances in chirally pure proton pump inhibitors. Journal of the Indian Medical Association 20070801
Effect of baseline symptom severity on patient-reported outcomes in gastroesophageal reflux disease. European journal of gastroenterology & hepatology 20070701
A clinical trial comparing pantoprazole and esomeprazole to explore the concept of achieving 'complete remission' in gastro-oesophageal reflux disease. Alimentary pharmacology & therapeutics 20070615
Soraprazan: setting new standards in inhibition of gastric acid secretion. The Journal of pharmacology and experimental therapeutics 20070601
One week of esomeprazole triple therapy vs 1 week of omeprazole triple therapy plus 3 weeks of omeprazole for duodenal ulcer healding in Helicobacter pylori-positive patients. Digestive diseases and sciences 20070601
Tegaserod for dyspepsia and reflux symptoms in patients with chronic constipation: an exploratory open-label study. European journal of clinical pharmacology 20070601
Severe systemic adverse reaction to proton pump inhibitors in an infant. Pediatric pulmonology 20070601
Effect of esomeprazole and rabeprazole on intragastric pH in healthy Chinese: an open, randomized crossover trial. Journal of gastroenterology and hepatology 20070601
[Protonic pump inhibitors in kidney transplant patients: efficacy and safety]. Minerva urologica e nefrologica = The Italian journal of urology and nephrology 20070601
[Different courses of esomeprazole-based triple therapy for Helicobactor pylori infection in children]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20070601
Suppression of gastric acid with intravenous esomeprazole and omeprazole: results of 3 studies in healthy subjects. International journal of clinical pharmacology and therapeutics 20070601
Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial. Lancet (London, England) 20070512
Helicobacter pylori eradication: a randomized prospective study of triple therapy versus triple therapy plus lactoferrin and probiotics. The American journal of gastroenterology 20070501
Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire. Alimentary pharmacology & therapeutics 20070501
Esomeprazole: prevention and treatment of NSAID-induced symptoms and ulcers. Expert opinion on pharmacotherapy 20070501
Determination of esomeprazole and its two main metabolites in human, rat and dog plasma by liquid chromatography with tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401
Efficacy of esomeprazole for resolution of symptoms of heartburn and acid regurgitation in continuous users of non-steroidal anti-inflammatory drugs. Alimentary pharmacology & therapeutics 20070401
Effect of lactoferrin supplementation on the effectiveness and tolerability of a 7-day quadruple therapy after failure of a first attempt to cure Helicobacter pylori infection. Medical science monitor : international medical journal of experimental and clinical research 20070401
A new esomeprazole packet (sachet) formulation for suspension: in vitro characteristics and comparative pharmacokinetics versus intact capsules/tablets in healthy volunteers. Clinical therapeutics 20070401
[Clinical pharmacological aspects of the proton pump inhibitor therapy: importance of pharmacogenetic differences in the clinical practice]. Orvosi hetilap 20070325
Efficacy of pantoprazole 20 mg daily compared with esomeprazole 20 mg daily in the maintenance of healed gastroesophageal reflux disease: a randomized, double-blind comparative trial - the EMANCIPATE study. European journal of gastroenterology & hepatology 20070301
Relationship between intragastric acid control and healing status in the treatment of moderate to severe erosive oesophagitis. Alimentary pharmacology & therapeutics 20070301
Effect of antireflux treatment on asthma exacerbations in nonatopic children. Journal of pediatric gastroenterology and nutrition 20070301
Use of intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis. The American journal of geriatric pharmacotherapy 20070301
Combined analysis of three crossover clinical pharmacology studies of effects of rabeprazole and esomeprazole on 24-h intragastric pH in healthy volunteers. Alimentary pharmacology & therapeutics 20070215
[Changes of intercellular spaces of esophageal epithelium in patients with gastroesophageal reflux disease before and after esomeprazole treatment]. Zhonghua yi xue za zhi 20070206
Does esomeprazole prevent post-operative nausea and vomiting? Acta anaesthesiologica Scandinavica 20070201
Effect of intravenous application of esomeprazole 40 mg versus pantoprazole 40 mg on 24-hour intragastric pH in healthy adults. European journal of gastroenterology & hepatology 20070201
Efficacy of once-daily esomeprazole treatment in patients with laryngopharyngeal reflux evaluated by 24-hour pH monitoring. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20070201
Acidic and non-acidic reflux during sleep under conditions of powerful acid suppression. Chest 20070201
Acid control with esomeprazole and lansoprazole: a comparative dose-response study. Scandinavian journal of gastroenterology 20070201
[Proton pump inhibitors in developmental period medicine]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20070201
Comparison of the effects of immediate-release omeprazole oral suspension, delayed-release lansoprazole capsules and delayed-release esomeprazole capsules on nocturnal gastric acidity after bedtime dosing in patients with night-time GERD symptoms. Alimentary pharmacology & therapeutics 20070115
Effect of oral esomeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. Journal of gastroenterology and hepatology 20070101
Maintenance treatment with esomeprazole following initial relief of non-steroidal anti-inflammatory drug-associated upper gastrointestinal symptoms: the NASA2 and SPACE2 studies. Arthritis research & therapy 20070101
Novel measurement of rapid treatment success with ReQuest: first and sustained symptom relief as outcome parameters in patients with endoscopy-negative GERD receiving 20 mg pantoprazole or 20 mg esomeprazole. Digestion 20070101
Pantoprazole 40 mg is as effective as esomeprazole 40 mg to relieve symptoms of gastroesophageal reflux disease after 4 weeks of treatment and superior regarding the prevention of symptomatic relapse. Digestion 20070101
Bioequivalence study of a sustained release fixed dose combination capsule containing esomeprazole and domperidone in healthy subjects. Arzneimittel-Forschung 20070101
Symptom resolution does not predict healing of erosive oesophagitis in Chinese. Digestion 20070101
The concept of complete remission of gastro-oesophageal reflux disease : comparative efficacy of pantoprazole and esomeprazole using the ReQuest questionnaire. Clinical drug investigation 20070101
Potential options to optimize therapy of gastroesophageal reflux disease with proton pump inhibitors. Digestion 20070101
Effect of intravenous esomeprazole 40 mg and pantoprazole 40 mg on intragastric pH in healthy subjects. A prospective, open, randomised, two-way cross-over comparative study. Arzneimittel-Forschung 20070101
[Efficiency and safety of the intravenous application of esomeprazole (nexium - Astra Zeneca) in high risk patients subjected to mechanic ventilation]. Khirurgiia 20070101
Esomeprazole versus other proton pump inhibitors in erosive esophagitis: a meta-analysis of randomized clinical trials. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20061201
An in vitro comparison of different providers to deliver four proton pump inhibitor products through a feeding tube. Alimentary pharmacology & therapeutics 20061201
[Antiplatelet therapy after aspirin-induced upper gastrointestinal bleeding]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20061102
Prospective follow-up data from the ProGERD study suggest that GERD is not a categorial disease. The American journal of gastroenterology 20061101
Randomized comparison of two rescue therapies for Helicobacter pylori infection. European journal of clinical investigation 20061101
Pharmacokinetic properties of esomeprazole in children aged 1 to 11 years with symptoms of gastroesophageal reflux disease: a randomized, open-label study. Clinical therapeutics 20061101
Delivery of esomeprazole magnesium through nasogastric and gastrostomy tubes using an oral liquid vehicle as a suspending agent in vitro. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20061001
Esomeprazole 40 mg once a day in patients with functional dyspepsia: the randomized, placebo-controlled 'ENTER' trial. The American journal of gastroenterology 20060901
Gastric and esophageal pH in patients with Barrett's esophagus treated with three esomeprazole dosages: a randomized, double-blind, crossover trial. The American journal of gastroenterology 20060901
Effects of single doses of rabeprazole 20 mg and esomeprazole 40 mg on 24-h intragastric pH in healthy subjects. European journal of clinical pharmacology 20060901
Systematic review: proton pump inhibitors (PPIs) for the healing of reflux oesophagitis - a comparison of esomeprazole with other PPIs. Alimentary pharmacology & therapeutics 20060901
Sequential therapy using high-dose esomeprazole-amoxicillin followed by gatifloxacin for Helicobacter pylori infection. Alimentary pharmacology & therapeutics 20060901
Treatment of chronic posterior laryngitis with esomeprazole. The Laryngoscope 20060901
Levofloxacin-based triple therapy in first-line treatment for Helicobacter pylori eradication. The American journal of gastroenterology 20060901
Esomeprazole versus pantoprazole for healing erosive oesophagitis. Collegium antropologicum 20060901
Ablation of nonneoplastic Barrett's mucosa using argon plasma coagulation with concomitant esomeprazole therapy (APBANEX): a prospective multicenter evaluation. The American journal of gastroenterology 20060801
Esomeprazole-based 1-week triple therapy directed by susceptibility testing for eradication of Helicobacter pylori infection in children. Journal of pediatric gastroenterology and nutrition 20060801
Role of the preliminary susceptibility testing for initial and after failed therapy of Helicobacter pylori infection with levofloxacin, amoxicillin, and esomeprazole. Helicobacter 20060801
Randomized trial of rifabutin-based triple therapy and high-dose dual therapy for rescue treatment of Helicobacter pylori resistant to both metronidazole and clarithromycin. Alimentary pharmacology & therapeutics 20060715
Maintenance of healed erosive esophagitis: a randomized six-month comparison of esomeprazole twenty milligrams with lansoprazole fifteen milligrams. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060701
Esomeprazole with aspirin versus clopidogrel for prevention of recurrent gastrointestinal ulcer complications. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060701
Clinical impact of CYP2C19 polymorphism on the action of proton pump inhibitors: a review of a special problem. International journal of clinical pharmacology and therapeutics 20060701
Review article: the opportunities and benefits of extended acid suppression. Alimentary pharmacology & therapeutics 20060601
Myopathy including polymyositis: a likely class adverse effect of proton pump inhibitors? European journal of clinical pharmacology 20060601
Eradication of Helicobacter pylori and dosages of esomeprazole. The American journal of gastroenterology 20060601
Effects of esomeprazole 40 mg twice daily on asthma: a randomized placebo-controlled trial. American journal of respiratory and critical care medicine 20060515
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Coadministration of esomeprazole with fosamprenavir has no impact on steady-state plasma amprenavir pharmacokinetics. Journal of acquired immune deficiency syndromes (1999) 20060501
A multicenter, randomized, double-blind, 8-week comparative trial of standard doses of esomeprazole (40 mg) and omeprazole (20 mg) for the treatment of erosive esophagitis. Digestive diseases and sciences 20060501
A multicenter, randomized, double-blind, 8-week comparative trial of low-dose esomeprazole (20 mg) and standard-dose omeprazole (20 mg) in patients with erosive esophagitis. Digestive diseases and sciences 20060501
Intragastric acidity after switching from 5-day treatment with intravenous pantoprazole 40 mg/d to 5-day treatment with oral esomeprazole 40 mg/d or pantoprazole 40 mg/d: an open-label crossover study in healthy adult volunteers. Clinical therapeutics 20060501
Intragastric acid control in non-steroidal anti-inflammatory drug users: comparison of esomeprazole, lansoprazole and pantoprazole. Alimentary pharmacology & therapeutics 20060415
Bovine lactoferrin for Helicobacter pylori eradication: an open, randomized, multicentre study. Alimentary pharmacology & therapeutics 20060415
Esomeprazole for the prevention of postoperative nausea and vomiting. A randomized, placebo-controlled trial. European journal of anaesthesiology 20060401
Prevention of ulcers by esomeprazole in at-risk patients using non-selective NSAIDs and COX-2 inhibitors. The American journal of gastroenterology 20060401
Effects of esomeprazole on the pharmacokinetics of atazanavir and fosamprenavir in a patient with human immunodeficiency virus infection. Pharmacotherapy 20060401
The effects of esomeprazole combined with aspirin or rofecoxib on prostaglandin E2 production in patients with Barrett's oesophagus. Alimentary pharmacology & therapeutics 20060401
A COX-2-specific inhibitor plus a proton-pump inhibitor: is this a reasonable approach to reduction in NSAIDs' GI toxicity? The American journal of gastroenterology 20060401
[Long-term treatment of patients with symptomatic gastroesophageal reflux disease comparing costs and efficacy over 6 months of treatment with Nexium On-Demand Treatment or Nexium continuous treatment. An open, randomised multi-center study]. Praxis 20060329
Studies on drug interactions between esomeprazole, amoxicillin and clarithromycin in healthy subjects. International journal of clinical pharmacology and therapeutics 20060301
Pharmacokinetic properties of esomeprazole in adolescent patients aged 12 to 17 years with symptoms of gastroesophageal reflux disease: A randomized, open-label study. Clinical therapeutics 20060301
Validation of a symptom diary for patients with gastro-oesophageal reflux disease. Alimentary pharmacology & therapeutics 20060215
Sensitive quantification of omeprazole and its metabolites in human plasma by liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202
Intra-oesophageal acid suppression in complicated gastro-oesophageal reflux disease: esomeprazole versus lansoprazole. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20060201
Upper gastrointestinal haemorrhage complicating antiplatelet treatment with aspirin and/or clopidogrel: where we are now? Platelets 20060201
7-day triple therapy of Helicobacter pylori infection with levofloxacin, amoxicillin, and high-dose esomeprazole in patients with known antimicrobial sensitivity. Helicobacter 20060201
Efficacy of moxifloxacin-based triple therapy as second-line treatment for Helicobacter pylori infection. Helicobacter 20060201
Twice-a-day quadruple therapy for eradication of Helicobacter pylori in the elderly. Helicobacter 20060201
Treatment of chronic posterior laryngitis with esomeprazole. The Laryngoscope 20060201
Helicobacter pylori eradication with either 7-day or 10-day triple therapies, and with a 10-day sequential regimen. Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20060201
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