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Home > Fluorides > 161605-73-8
161605-73-8 | Phosphonic acid, P-[[3,4-dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]-
CAS No: 161605-73-8 Catalog No: AG001VQR MDL No:MFCD07364000
Product Description
Catalog Number:
AG001VQR
Chemical Name:
Phosphonic acid, P-[[3,4-dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]-
CAS Number:
161605-73-8
Molecular Formula:
C14H15F3N3O6P
Molecular Weight:
409.2544
MDL Number:
MFCD07364000
IUPAC Name:
[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]methylphosphonic acid
InChI:
InChI=1S/C14H15F3N3O6P/c15-14(16,17)8-5-9-11(6-10(8)19-1-3-26-4-2-19)20(7-27(23,24)25)13(22)12(21)18-9/h5-6H,1-4,7H2,(H,18,21)(H2,23,24,25)
InChI Key:
WZMQMKNCWDCCMT-UHFFFAOYSA-N
SMILES:
O=c1[nH]c2cc(c(cc2n(c1=O)CP(=O)(O)O)N1CCOCC1)C(F)(F)F
UNII:
E3AP71EM0O
Properties
Complexity:
651
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
409.065g/mol
Formal Charge:
0
Heavy Atom Count:
27
Hydrogen Bond Acceptor Count:
10
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
409.258g/mol
Monoisotopic Mass:
409.065g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
119A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.5
Literature
| Title | Journal |
|---|---|
| alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside. | Journal of medicinal chemistry 20100812 |
| Effects of the AMPA antagonist ZK 200775 on visual function: a randomized controlled trial. | PloS one 20100101 |
| Involvement of glutamate neurotransmission and N-methyl-d-aspartate receptor in the activation of midbrain dopamine neurons by 5-HT1A receptor agonists: an electrophysiological study in the rat. | Neuroscience 20081028 |
| Nicotine-induced dopamine release in the nucleus accumbens is inhibited by the novel AMPA antagonist ZK200775 and the NMDA antagonist CGP39551. | Psychopharmacology 20040801 |
| AMPA antagonist ZK200775 in patients with acute ischemic stroke: possible glial cell toxicity detected by monitoring of S-100B serum levels. | Stroke 20021201 |
| Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz. | Bioorganic & medicinal chemistry letters 20010507 |
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