200,000+ products from a single source!
sales@angenechem.com
CAS No: 1614-12-6 Catalog No: AG001SG5 MDL No:MFCD00132902
Title | Journal |
---|---|
1,2-Dichloropropane generates phosphorylated histone H2AX via cytochrome P450 2E1-mediated metabolism. | Toxicology letters 20170415 |
Preliminary characterization of a murine model for 1-bromopropane neurotoxicity: Role of cytochrome P450. | Toxicology letters 20160906 |
Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism. | Journal of applied toxicology : JAT 20160101 |
Genotoxicity of 1-methylpyrene and 1-hydroxymethylpyrene in Chinese hamster V79-derived cells expressing both human CYP2E1 and SULT1A1. | Environmental and molecular mutagenesis 20150501 |
Metabolic pathways leading to detoxification of triptolide, a major active component of the herbal medicine Tripterygium wilfordii. | Journal of applied toxicology : JAT 20140801 |
Regulation of CYP3A genes by glucocorticoids in human lung cells. | F1000Research 20130101 |
Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes. | Toxicology and applied pharmacology 20121101 |
Bioactivation of nevirapine to a reactive quinone methide: implications for liver injury. | Chemical research in toxicology 20120820 |
Covalent modification and time-dependent inhibition of human CYP2E1 by the meta-isomer of acetaminophen. | Drug metabolism and disposition: the biological fate of chemicals 20120801 |
Definition of metabolism-dependent xenobiotic toxicity with co-cultures of human hepatocytes and mouse 3T3 fibroblasts in the novel integrated discrete multiple organ co-culture (IdMOC) experimental system: results with model toxicants aflatoxin B1, cyclophosphamide and tamoxifen. | Chemico-biological interactions 20120730 |
Metabolic activation and major protein target of a 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonist. | Chemical research in toxicology 20120716 |
Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine. | European journal of pharmacology 20120705 |
Vestibular toxicity of cis-2-pentenenitrile in the rat. | Toxicology letters 20120620 |
[Metabolic detoxification of bakuchiol is mediated by cytochrome P450 enzymes in human liver microsomes]. | Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20120618 |
Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors. | Drug metabolism and disposition: the biological fate of chemicals 20120501 |
Cytochrome P450 11A1 bioactivation of a kinase inhibitor in rats: use of radioprofiling, modulation of metabolism, and adrenocortical cell lines to evaluate adrenal toxicity. | Chemical research in toxicology 20120319 |
Absorption, translocation and metabolism of metamitron in Chenopodium album. | Pest management science 20120201 |
Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20120201 |
Determination of metabolic profile of anti-malarial trioxane CDRI 99/411 in rat liver microsomes using HPLC. | Biomedical chromatography : BMC 20120101 |
Testosterone-dependent increase in blood pressure is mediated by elevated Cyp4A expression in fructose-fed rats. | Molecular and cellular biochemistry 20120101 |
Cytochrome P-450-catalyzed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in H9c2 cardiomyocytes. | Indian journal of pharmacology 20120101 |
The genotoxic potential of methapyrilene using the alkaline Comet assay in vitro and in vivo. | Toxicology 20111218 |
Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes. | Biochemical and biophysical research communications 20111216 |
Biotransformation of the organochlorine pesticide trans-chlordane by wood-rot fungi. | New biotechnology 20111215 |
Degradation of the antibiotics norfloxacin and ciprofloxacin by a white-rot fungus and identification of degradation products. | Bioresource technology 20111201 |
Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. | Toxicology and applied pharmacology 20111201 |
Biotransformation enzyme-dependent formation of micronucleus and multinuclei in cell line V79-hCYP2E1-hSULT1A1 by 2-nitropropane and N-nitrosodimethylamine. | Mutation research 20111127 |
Inhibition of cytochrome P450 enzymes involved in ketamine metabolism by use of liver microsomes and specific cytochrome P450 enzymes from horses, dogs, and humans. | American journal of veterinary research 20111101 |
Cross talk between keratinocytes and dendritic cells: impact on the prediction of sensitization. | Toxicological sciences : an official journal of the Society of Toxicology 20111001 |
Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices. | Chemico-biological interactions 20110905 |
1-Aminobenzotriazole, a known cytochrome P450 inhibitor, is a substrate and inhibitor of N-acetyltransferase. | Drug metabolism and disposition: the biological fate of chemicals 20110901 |
Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction. | Journal of biomolecular screening 20110901 |
Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes. | Toxicological sciences : an official journal of the Society of Toxicology 20110801 |
The imidazoacridinone antitumor drug, C-1311, is metabolized by flavin monooxygenases but not by cytochrome P450s. | Drug metabolism and disposition: the biological fate of chemicals 20110801 |
Higher throughput human hepatocyte assays for the evaluation of time-dependent inhibition of CYP3A4. | Drug metabolism letters 20110801 |
Postmenopausal hypertension: role of 20-HETE. | American journal of physiology. Regulatory, integrative and comparative physiology 20110601 |
Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity. | Toxicology and applied pharmacology 20110501 |
Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model. | Archives of toxicology 20110401 |
Interaction of nitric oxide and the cytochrome P-450 system on blood pressure and renal function in the rat: dependence on sodium intake. | Acta physiologica (Oxford, England) 20110401 |
Reductive metabolism of the dinitrobenzamide mustard anticancer prodrug PR-104 in mice. | Cancer chemotherapy and pharmacology 20110301 |
Bach1 gene ablation reduces steatohepatitis in mouse MCD diet model. | Journal of clinical biochemistry and nutrition 20110301 |
Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening. | Drug metabolism and disposition: the biological fate of chemicals 20110201 |
Dual effects of estrogen on vascular smooth muscle cells: receptor-mediated proliferative vs. metabolite-induced pro-senescent actions. | Steroids 20110201 |
An oxygenase inhibitor study in Solanum lycopersicum combined with metabolite profiling analysis revealed a potent peroxygenase inactivator. | Journal of experimental botany 20110101 |
The effect of cocoa supplementation on hepatic steatosis, reactive oxygen species and LFABP in a rat model of NASH. | Comparative hepatology 20110101 |
In vitro hepatic metabolism of cediranib, a potent vascular endothelial growth factor tyrosine kinase inhibitor: interspecies comparison and human enzymology. | Drug metabolism and disposition: the biological fate of chemicals 20101001 |
Methodologies for investigating drug metabolism at the early drug discovery stage: prediction of hepatic drug clearance and P450 contribution. | Current drug metabolism 20101001 |
Removal of diclofenac and mefenamic acid by the white rot fungus Phanerochaete sordida YK-624 and identification of their metabolites after fungal transformation. | Biodegradation 20100901 |
Reactive oxygen species and small-conductance calcium-dependent potassium channels are key mediators of inflammation-induced hypotension and shock. | Journal of molecular medicine (Berlin, Germany) 20100901 |
Induction of CYP2B6 and CYP3A4 expression by 1-aminobenzotriazole (ABT) in human hepatocytes. | Drug metabolism letters 20100801 |
Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor. | Xenobiotica; the fate of foreign compounds in biological systems 20100601 |
Derivatization of the azole 1-aminobenzotriazole using laccase of Pycnoporus cinnabarinus and Myceliophthora thermophila: influence of methanol on the reaction and biological evaluation of the derivatives. | Biotechnology and applied biochemistry 20100527 |
Differential oxidative metabolism and 5-ketoclomazone accumulation are involved in Echinochloa phyllopogon resistance to clomazone. | Plant physiology 20100501 |
Degradation of the drug sodium diclofenac by Trametes versicolor pellets and identification of some intermediates by NMR. | Journal of hazardous materials 20100415 |
Biodegradation of the analgesic naproxen by Trametes versicolor and identification of intermediates using HPLC-DAD-MS and NMR. | Bioresource technology 20100401 |
3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively. | Chemical research in toxicology 20100315 |
Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis. | Environmental and molecular mutagenesis 20100101 |
Biotransformation of beta-myrcene to geraniol by a strain of Rhodococcus erythropolis isolated by selective enrichment from hop plants. | Applied microbiology and biotechnology 20100101 |
White-rot fungus-mediated degradation of the analgesic ketoprofen and identification of intermediates by HPLC-DAD-MS and NMR. | Chemosphere 20100101 |
Investigation of the intestinal permeability and first-pass metabolism of drugs in cynomolgus monkeys using single-pass intestinal perfusion. | Biological & pharmaceutical bulletin 20100101 |
20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice. | PloS one 20100101 |
Benzyne arylation of oxathiane glycosyl donors. | Beilstein journal of organic chemistry 20100101 |
Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice. | Lipids in health and disease 20100101 |
Capsaicinoids, chloropicrin and sulfur mustard: possibilities for exposure biomarkers. | Frontiers in pharmacology 20100101 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers. | Drug metabolism and disposition: the biological fate of chemicals 20090801 |
Differential action of bradykinin on intrarenal regional perfusion in the rat: waning effect in the cortex and major impact in the medulla. | The Journal of physiology 20090801 |
Dechlorination of 1,2,3- and 1,2,4-trichlorobenzene by the white-rot fungus Trametes versicolor. | Journal of hazardous materials 20090730 |
Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice. | Archives of toxicology 20090701 |
Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1. | Chemico-biological interactions 20090415 |
Allylnitrile metabolism by CYP2E1 and other CYPs leads to distinct lethal and vestibulotoxic effects in the mouse. | Toxicological sciences : an official journal of the Society of Toxicology 20090201 |
Ability of white-rot fungi to remove selected pharmaceuticals and identification of degradation products of ibuprofen by Trametes versicolor. | Chemosphere 20090201 |
Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator? | Drug metabolism and disposition: the biological fate of chemicals 20090101 |
Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes. | Autonomic & autacoid pharmacology 20090101 |
Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice. | Scandinavian journal of gastroenterology 20090101 |
Involvement of cytochrome P450-mediated metabolism in tienilic acid hepatotoxicity in rats. | Toxicology letters 20081215 |
Nonenzymatic formation of a novel hydroxylated sulfamethoxazole derivative in human liver microsomes: implications for bioanalysis of sulfamethoxazole metabolites. | Drug metabolism and disposition: the biological fate of chemicals 20081201 |
Inhibition of rat aortic smooth muscle contraction by 2-methoxyestradiol. | American journal of physiology. Heart and circulatory physiology 20081101 |
Validation of the use of nonnaive surgically catheterized rats for pharmacokinetics studies. | Journal of the American Association for Laboratory Animal Science : JAALAS 20081101 |
Responses to clomazone and 5-ketoclomazone by Echinochloa phyllopogon resistant to multiple herbicides in Californian rice fields. | Pest management science 20081001 |
Mechanistic investigation of the noncytochrome P450-mediated metabolism of triadimefon to triadimenol in hepatic microsomes. | Chemical research in toxicology 20081001 |
Role of biotransformation in 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione-induced hepatotoxicity in Fischer 344 rats. | Toxicology 20080904 |
Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash. | Chemical research in toxicology 20080901 |
Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes. | Mutation research 20080825 |
Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore. | The Journal of pharmacology and experimental therapeutics 20080801 |
Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726. | Drug metabolism letters 20080801 |
Estradiol and the estradiol metabolite, 2-hydroxyestradiol, activate AMP-activated protein kinase in C2C12 myotubes. | Obesity (Silver Spring, Md.) 20080601 |
Role of hydrazine in isoniazid-induced hepatotoxicity in a hepatocyte inflammation model. | Toxicology and applied pharmacology 20080515 |
Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20080501 |
Accelerated cytotoxic mechanism screening of hydralazine using an in vitro hepatocyte inflammatory cell peroxidase model. | Chemical research in toxicology 20080401 |
The use of 1-aminobenzotriazole in differentiating the role of CYP-mediated first pass metabolism and absorption in limiting drug oral bioavailability: a case study. | Drug metabolism letters 20080401 |
Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery. | The AAPS journal 20080301 |
1-Phenyl-4-(triphenyl-phosphanyl-idene)pyrrolidine-2,3,5-trione. | Acta crystallographica. Section E, Structure reports online 20080301 |
Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with an N -sulfonylated dipeptide VLA-4 antagonist in rats. | Xenobiotica; the fate of foreign compounds in biological systems 20080201 |
Mechanistics of trichloroethylene mineralization by the white-rot fungus Trametes versicolor. | Chemosphere 20080101 |
In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers. | Molecular pharmacology 20071201 |
CYP3A4 and CYP3A5 catalyse the conversion of the N-methyl-D-aspartate (NMDA) antagonist CJ-036878 to two novel dimers. | Xenobiotica; the fate of foreign compounds in biological systems 20071201 |
Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase. | Bioorganic & medicinal chemistry letters 20071115 |
The cytochrome p450 inhibitor ketoconazole potentiates 5-hydroxytryptamine-induced contraction in rat aorta. | The Journal of pharmacology and experimental therapeutics 20071101 |
Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. | Drug metabolism and disposition: the biological fate of chemicals 20071101 |
Degradation of 2,5-dimethylpyrazine by Rhodococcus erythropolis strain DP-45 isolated from a waste gas treatment plant of a fishmeal processing company. | Biodegradation 20071001 |
Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites. | Chemical research in toxicology 20071001 |
The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore. | The Journal of pharmacology and experimental therapeutics 20070901 |
Induction of DNA strand breaks and oxidative stress in HeLa cells by ethanol is dependent on CYP2E1 expression. | Mutagenesis 20070501 |
Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. | Journal of immunology (Baltimore, Md. : 1950) 20070501 |
Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis. | Hypertension (Dallas, Tex. : 1979) 20070301 |
Reactivity of dehydrometallophthalocyanines and -porphyrazines. | Chemistry (Weinheim an der Bergstrasse, Germany) 20070101 |
Effects of ATP on rat renal haemodynamics and excretion: role of sodium intake, nitric oxide and cytochrome P450. | Acta physiologica (Oxford, England) 20070101 |
Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic rats. | Vascular pharmacology 20070101 |
Novel aerobic perchloroethylene degradation by the white-rot fungus Trametes versicolor. | Environmental science & technology 20061215 |
Comparative metabolism and disposition of trichloroethylene in Cyp2e1-/-and wild-type mice. | Drug metabolism and disposition: the biological fate of chemicals 20061201 |
Hydroxyeicosatetraenoic acids released through the cytochrome P-450 pathway regulate 3T6 fibroblast growth. | Journal of lipid research 20061201 |
CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]. | Drug metabolism and disposition: the biological fate of chemicals 20061201 |
Effects of quercetin on beta-apo-8'-carotenal-induced DNA damage and cytochrome P1A2 expression in A549 cells. | Chemico-biological interactions 20061107 |
Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101 |
Acrylonitrile-induced oxidative DNA damage in rat astrocytes. | Environmental and molecular mutagenesis 20061001 |
Nitric oxide/cytochrome P450 interactions in cyclosporin A-induced effects in the rat. | Journal of hypertension 20060901 |
Metabolism and disposition of 1-bromopropane in rats and mice following inhalation or intravenous administration. | Toxicology and applied pharmacology 20060815 |
Regioselective hydroxylation of adamantane by Streptomyces griseoplanus cells. | Applied microbiology and biotechnology 20060701 |
Activation of T cells by carbamazepine and carbamazepine metabolites. | The Journal of allergy and clinical immunology 20060701 |
In vivo use of the P450 inactivator 1-aminobenzotriazole in the rat: varied dosing route to elucidate gut and liver contributions to first-pass and systemic clearance. | Journal of pharmaceutical sciences 20060601 |
Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
Growth of Phanerochaete chrysosporium on diesel fuel hydrocarbons at neutral pH. | Chemosphere 20060401 |
Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone. | Toxicological sciences : an official journal of the Society of Toxicology 20060401 |
Flavonoids suppresses the enhancing effect of beta-carotene on DNA damage induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A549 cells. | Chemico-biological interactions 20060325 |
Inhibition by nitric oxide of cytochrome P450 4A activity contributes to endotoxin-induced hypotension in rats. | Nitric oxide : biology and chemistry 20060201 |
Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus. | American journal of physiology. Renal physiology 20051201 |
Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver. | Life sciences 20051021 |
Contribution of cytochrome P450 metabolites of arachidonic acid to hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME. | Autonomic & autacoid pharmacology 20051001 |
In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A. | Drug metabolism and pharmacokinetics 20051001 |
Inhibition of Ca2+/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery. | Pharmacological research 20050901 |
Effect of 1-aminobenzotriazole on the in vitro metabolism and single-dose pharmacokinetics of chlorzoxazone, a selective CYP2E1 substrate in Wistar rats. | Xenobiotica; the fate of foreign compounds in biological systems 20050801 |
Comparative metabolism of methacrylonitrile and acrylonitrile to cyanide using cytochrome P4502E1 and microsomal epoxide hydrolase-null mice. | Toxicology and applied pharmacology 20050601 |
Extrahepatic metabolism of carbamate and organophosphate thioether compounds by the flavin-containing monooxygenase and cytochrome P450 systems. | Drug metabolism and disposition: the biological fate of chemicals 20050201 |
Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver. | Hepatology (Baltimore, Md.) 20050201 |
Preparation of tertiary alkyl carbinamines, propargylamines, and alpha-heteroarylamines by ketone-based aminoalkylation. | The Journal of organic chemistry 20050107 |
A role for one or more p450 enzymes in the response to sepsis. | Critical care medicine 20050101 |
The use of the suicide CYP450 inhibitor ABT for distinguishing absorption and metabolism processes in in-vivo pharmacokinetic screens. | European journal of drug metabolism and pharmacokinetics 20050101 |
Expression and activities of several drug-metabolizing enzymes in LLC-PK1 cells. | Toxicology in vitro : an international journal published in association with BIBRA 20041201 |
Subchronic acrylamide treatment induces a tissue-specific increase in DNA synthesis in the rat. | Toxicology letters 20041201 |
Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in guinea pigs and mice using serial sampling. | Drug metabolism and disposition: the biological fate of chemicals 20041001 |
Endothelial cytochrome P450 contributes to the acetylcholine-induced cardiodepression in isolated rat hearts. | Acta physiologica Scandinavica 20040901 |
Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis. | American journal of physiology. Regulatory, integrative and comparative physiology 20040701 |
The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6. | Drug metabolism and disposition: the biological fate of chemicals 20040401 |
Cytochrome P-450 inhibition attenuates hypertension induced by reductions in uterine perfusion pressure in pregnant rats. | Hypertension (Dallas, Tex. : 1979) 20040301 |
Cytochrome P450-catalyzed brassinosteroid pathway activation through synthesis of castasterone and brassinolide in Phaseolus vulgaris. | Phytochemistry 20040301 |
Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A). | Chemical research in toxicology 20040301 |
Down-regulation of hepatic CYP1A2 plays an important role in inflammatory responses in sepsis. | Critical care medicine 20040201 |
The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice. | Free radical biology & medicine 20031215 |
Studies on the metabolism of the thiofurans furfuryl mercaptan and 2-methyl-3-furanthiol in rat liver. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20031201 |
Inhibitors of 20-HETE formation promote salt-sensitive hypertension in rats. | Hypertension (Dallas, Tex. : 1979) 20031001 |
Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in peripheral human lung microsomes. | Drug metabolism and disposition: the biological fate of chemicals 20030901 |
Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats. | American journal of physiology. Renal physiology 20030801 |
Effect of cytochrome P-450 inhibition on tetrahydrofuran-induced hepatocellular proliferation in female mice. | Archives of toxicology 20030801 |
NO inhibits Na+-K+-2Cl- cotransport via a cytochrome P-450-dependent pathway in renal epithelial cells (MMDD1). | American journal of physiology. Renal physiology 20030601 |
The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats. | Free radical biology & medicine 20030601 |
CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis. | American journal of physiology. Heart and circulatory physiology 20030501 |
Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes. | Drug metabolism and disposition: the biological fate of chemicals 20030501 |
Cytochrome P450 2E1 (CYP2E1) is the principal enzyme responsible for urethane metabolism: comparative studies using CYP2E1-null and wild-type mice. | The Journal of pharmacology and experimental therapeutics 20030501 |
Biodegradation of chloronaphthalenes and polycyclic aromatic hydrocarbons by the white-rot fungus Phlebia lindtneri. | Applied microbiology and biotechnology 20030501 |
Concurrent corticosteroid and phenanthrene transformation by filamentous fungus Cunninghamella elegans. | The Journal of steroid biochemistry and molecular biology 20030501 |
[Effects of acrylamide on DNA damage in human keratinocytes]. | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20030401 |
Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. | Chemical research in toxicology 20030301 |
3-methylindole-induced toxicity to human bronchial epithelial cell lines. | Toxicological sciences : an official journal of the Society of Toxicology 20030201 |
In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole. | Drug metabolism and pharmacokinetics 20030101 |
Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in rats, dogs, and monkeys. | Drug metabolism and disposition: the biological fate of chemicals 20021001 |
Oxidation of dibenzo- p-dioxin, dibenzofuran, biphenyl, and diphenyl ether by the white-rot fungus Phlebia lindtneri. | Applied microbiology and biotechnology 20021001 |
Investigation of the role of lipoxygenase in bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung. | Chemical research in toxicology 20021001 |
NTP Technical Report on the metabolism, toxicity and predicted carcinogenicity of diazoaminobenzene (CAS No. 136-35-6). | Toxicity report series 20020901 |
Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II. | American journal of physiology. Regulatory, integrative and comparative physiology 20020701 |
Mechanisms for the induction of oxidative stress in Syrian hamster embryo cells by acrylonitrile. | Toxicological sciences : an official journal of the Society of Toxicology 20020601 |
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
Methoxyestradiols mediate estradiol-induced antimitogenesis in human aortic SMCs. | Hypertension (Dallas, Tex. : 1979) 20020401 |
Renal 20-hydroxyeicosatetraenoic acid synthesis during pregnancy. | American journal of physiology. Regulatory, integrative and comparative physiology 20020201 |
Acrylamide-induced cellular transformation. | Toxicological sciences : an official journal of the Society of Toxicology 20020201 |
Renal damage, metabolism and covalent binding following administration of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide (NDPS) to male Fischer 344 rats. | Toxicology 20020125 |
Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. | Bioorganic & medicinal chemistry letters 20011203 |
Role of guanylyl cyclase and cytochrome P-450 on renal response to nitric oxide. | American journal of physiology. Renal physiology 20010901 |
State-dependent block of rabbit vascular smooth muscle delayed rectifier and Kv1.5 channels by inhibitors of cytochrome P450-dependent enzymes. | The Journal of pharmacology and experimental therapeutics 20010801 |
Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes). | Toxicological sciences : an official journal of the Society of Toxicology 20010601 |
Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect. | American journal of physiology. Heart and circulatory physiology 20010601 |
An evaluation of the mutagenicity, metabolism, and DNA adduct formation of 5-nitrobenzo[b]naphtho[2,1-d]thiophene. | Chemical research in toxicology 20010601 |
Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors. | Cancer gene therapy 20010601 |
Inhibition of cytochrome P450 2E1 decreases, but does not eliminate, genotoxicity mediated by 1,3-butadiene. | Toxicological sciences : an official journal of the Society of Toxicology 20000601 |
The contribution of oxidation and deacetylation to acetaminophen nephrotoxicity in female Sprague-Dawley rats. | Toxicology letters 19970919 |
Benzoic acid 2-hydroxylase, a soluble oxygenase from tobacco, catalyzes salicylic acid biosynthesis. | Proceedings of the National Academy of Sciences of the United States of America 19951024 |
Purification and properties of isoenzymes of cinnamyl-alcohol dehydrogenase from soybean-cell-suspension cultures. | European journal of biochemistry 19751101 |
© 2019 Angene International Limited. All rights Reserved.