200,000+ products from a single source!
sales@angenechem.com
161230-88-2 | 1H-Indole-2-carboxylic acid, 3-[(1E)-2-carboxy-2-phenylethenyl]-4,6-dichloro-
CAS No: 161230-88-2 Catalog No: AG001S9J MDL No:MFCD00935266
Product Description
Catalog Number:
AG001S9J
Chemical Name:
1H-Indole-2-carboxylic acid, 3-[(1E)-2-carboxy-2-phenylethenyl]-4,6-dichloro-
CAS Number:
161230-88-2
Molecular Formula:
C18H11Cl2NO4
Molecular Weight:
376.1902
MDL Number:
MFCD00935266
IUPAC Name:
3-[(E)-2-carboxy-2-phenylethenyl]-4,6-dichloro-1H-indole-2-carboxylic acid
InChI:
InChI=1S/C18H11Cl2NO4/c19-10-6-13(20)15-12(16(18(24)25)21-14(15)7-10)8-11(17(22)23)9-4-2-1-3-5-9/h1-8,21H,(H,22,23)(H,24,25)/b11-8+
InChI Key:
LPWVUDLZUVBQGP-DHZHZOJOSA-N
SMILES:
Clc1cc(Cl)c2c(c1)[nH]c(c2/C=C(\c1ccccc1)/C(=O)O)C(=O)O
Properties
Complexity:
561
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1
Exact Mass:
375.007g/mol
Formal Charge:
0
Heavy Atom Count:
25
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
376.189g/mol
Monoisotopic Mass:
375.007g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
90.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.8
Literature
| Title | Journal |
|---|---|
| Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation. | Synapse (New York, N.Y.) 20091001 |
| Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070901 |
| CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist. | Journal of medicinal chemistry 20050224 |
| An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance. | The Journal of pharmacology and experimental therapeutics 20050201 |
| Model structures of the N-methyl-D-aspartate receptor subunit NR1 explain the molecular recognition of agonist and antagonist ligands. | Journal of structural biology 20040301 |
| Variations of acidic functions at position 2 and substituents at positions 4, 5 and 6 of the indole moiety and their effect on NMDA-glycine site affinity. | European journal of medicinal chemistry 20031001 |
| Expression of a soluble glycine binding domain of the NMDA receptor in Escherichia coli. | Biochemical and biophysical research communications 20030606 |
| Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors. | Bioscience, biotechnology, and biochemistry 20021201 |
| Radioligand binding assays for the glycine site on N-methyl-D-aspartate receptors. | Current protocols in pharmacology 20020801 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| 4-Hydroxy-6-oxo-6,7-dihydro-thieno[2,3-b] pyrimidine derivatives: synthesis and their biological evaluation for the glycine site acting on the N-methyl-D-aspartate (NMDA) receptor. | Archives of pharmacal research 20010801 |
| Ontogeny of ionotropic glutamate receptor expression in human fetal brain. | Brain research. Developmental brain research 20010430 |
| NMDA recepter-mediated neuroprotection by essential oils from the rhizomes of Acorus gramineus. | Life sciences 20010216 |
| Characterization of the binding of two novel glycine site antagonists to cloned NMDA receptors: evidence for two pharmacological classes of antagonists. | British journal of pharmacology 20000501 |
| [3H]MDL 105,519 binds with equal high affinity to both assembled and unassembled NR1 subunits of the NMDA receptor. | European journal of pharmacology 19980717 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.