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Home > Other Building Blocks > 16106-95-9
16106-95-9 | 2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-, (2Z,6Z)-
CAS No: 16106-95-9 Catalog No: AG001VMU MDL No:
Product Description
Catalog Number:
AG001VMU
Chemical Name:
2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-, (2Z,6Z)-
CAS Number:
16106-95-9
Molecular Formula:
C15H26O
Molecular Weight:
222.3663
IUPAC Name:
(2Z,6Z)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol
InChI:
InChI=1S/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3/b14-9-,15-11-
InChI Key:
CRDAMVZIKSXKFV-FBXUGWQNSA-N
SMILES:
OC/C=C(\CC/C=C(\CCC=C(C)C)/C)/C
EC Number:
225-004-1
UNII:
J03523NK03
FEMA Number:
2478
Properties
Complexity:
265
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
2
Exact Mass:
222.198g/mol
Formal Charge:
0
Heavy Atom Count:
16
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
222.372g/mol
Monoisotopic Mass:
222.198g/mol
Rotatable Bond Count:
7
Topological Polar Surface Area:
20.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.8
Literature
| Title | Journal |
|---|---|
| Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer. | Investigational new drugs 20121201 |
| Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes. | Veterinary microbiology 20121012 |
| Celecoxib enhances the anti-inflammatory effects of farnesylthiosalicylic acid on T cells independent of prostaglandin E(2) production. | Inflammation 20121001 |
| Farnesol and cyclic AMP signaling effects on the hypha-to-yeast transition in Candida albicans. | Eukaryotic cell 20121001 |
| A convergent stereocontrolled total synthesis of (-)-terpestacin. | Organic & biomolecular chemistry 20120728 |
| HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. | Blood 20120726 |
| Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin. | Journal of proteomics 20120716 |
| Quorum sensing activity in Ophiostoma ulmi: effects of fusel oils and branched chain amino acids on yeast-mycelial dimorphism. | Journal of applied microbiology 20120701 |
| Miconazole, a pharmacological barrier to skin fungal infections. | Expert opinion on pharmacotherapy 20120601 |
| Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. | Oncotarget 20120601 |
| Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells. | Biochemical and biophysical research communications 20120504 |
| Pravastatin inhibits farnesol production in Candida albicans and improves survival in a mouse model of systemic candidiasis. | Medical mycology 20120501 |
| Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501 |
| Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis. | International journal of cancer 20120315 |
| Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). | Journal of experimental botany 20120301 |
| Terpene alcohols inhibit de novo sphingolipid biosynthesis. | Planta medica 20120301 |
| Farnesyltransferase inhibitors: molecular evidence of therapeutic efficacy in acute lymphoblastic leukemia through cyclin D1 inhibition. | Anticancer research 20120301 |
| FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice. | Cell death & disease 20120301 |
| Prevention of induced colitis in mice by the ras antagonist farnesylthiosalicylic acid. | Digestive diseases and sciences 20120201 |
| Benzo(a)pyrene-induced pulmonary inflammation, edema, surfactant dysfunction, and injuries in rats: alleviation by farnesol. | Experimental lung research 20120201 |
| Ras inhibition by FTS attenuates brain tumor growth in mice by direct antitumor activity and enhanced reactivity of cytotoxic lymphocytes. | Oncotarget 20120201 |
| Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. | Neuroscience 20120127 |
| Candida and invasive candidiasis: back to basics. | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20120101 |
| Confocal laser scanning microscopy analysis of S. epidermidis biofilms exposed to farnesol, vancomycin and rifampicin. | BMC research notes 20120101 |
| Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production. | PloS one 20120101 |
| Functional characterization of the small heat shock protein Hsp12p from Candida albicans. | PloS one 20120101 |
| Farnesol decreases biofilms of Staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin. | Pediatric research 20111201 |
| Candida albicans developmental regulation: adenylyl cyclase as a coincidence detector of parallel signals. | Current opinion in microbiology 20111201 |
| Alcohol-based quorum sensing plays a role in adhesion and sliding motility of the yeast Debaryomyces hansenii. | FEMS yeast research 20111201 |
| [Analysis on the compositions of volatile oil of Alpinia henryi with GC-MS method]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20111201 |
| Hepatic FXR: key regulator of whole-body energy metabolism. | Trends in endocrinology and metabolism: TEM 20111101 |
| Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways. | American journal of physiology. Endocrinology and metabolism 20111101 |
| Zap1 control of cell-cell signaling in Candida albicans biofilms. | Eukaryotic cell 20111101 |
| Roles of Ras1 membrane localization during Candida albicans hyphal growth and farnesol response. | Eukaryotic cell 20111101 |
| Characterization of a hyperactive Cyr1 mutant reveals new regulatory mechanisms for cellular cAMP levels in Candida albicans. | Molecular microbiology 20111101 |
| Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release. | Inflammation 20111001 |
| Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential Rap1 inhibitor. | The Journal of investigative dermatology 20111001 |
| Effect of farnesol on structure and composition of Staphylococcus epidermidis biofilm matrix. | Current microbiology 20111001 |
| Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans. | Biochemical Society transactions 20111001 |
| Quorum sensing in fungi: Q&A. | PLoS pathogens 20111001 |
| Biosynthesis of unnatural bacteriochlorophyll c derivatives esterified with α,ω-diols in the green sulfur photosynthetic bacterium Chlorobaculum tepidum. | Biochemistry 20110913 |
| Antimicrobial traits of tea- and cranberry-derived polyphenols against Streptococcus mutans. | Caries research 20110901 |
| Enzymatic synthesis of farnesyl laurate in organic solvent: initial water activity, kinetics mechanism, optimization of continuous operation using packed bed reactor and mass transfer studies. | Bioprocess and biosystems engineering 20110801 |
| Phenotypic reversion of invasive neurofibromin-deficient schwannoma by FTS: Ras inhibition reduces BMP4/Erk/Smad signaling. | Molecular cancer therapeutics 20110801 |
| Modulation of morphogenesis in Candida albicans by various small molecules. | Eukaryotic cell 20110801 |
| The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. | Eukaryotic cell 20110801 |
| Roles for farnesol and ABA in Arabidopsis flower development. | Plant signaling & behavior 20110801 |
| Effect of farnesol on mevalonate pathway of Staphylococcus aureus. | The Journal of antibiotics 20110801 |
| A phase II trial of Salirasib in patients with lung adenocarcinomas with KRAS mutations. | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110801 |
| Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats. | Chemico-biological interactions 20110715 |
| Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains. | Mutation research 20110714 |
| The geranyl-modified tryptophan residue is crucial for ComXRO-E-2 pheromone biological activity. | Bioorganic & medicinal chemistry letters 20110701 |
| ZL11n is a novel nitric oxide-releasing derivative of farnesylthiosalicylic acid that induces apoptosis in human hepatoma HepG2 cells via MAPK/mitochondrial pathways. | Biochemical and biophysical research communications 20110617 |
| Farnesol kinase is involved in farnesol metabolism, ABA signaling and flower development in Arabidopsis. | The Plant journal : for cell and molecular biology 20110601 |
| Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol. | Chemico-biological interactions 20110530 |
| Evidence for differential biosynthesis of juvenile hormone (and related) sesquiterpenoids in Drosophila melanogaster. | General and comparative endocrinology 20110515 |
| Novel nitric oxide-releasing derivatives of farnesylthiosalicylic acid: synthesis and evaluation of antihepatocellular carcinoma activity. | Journal of medicinal chemistry 20110512 |
| Influences of trans-trans farnesol, a membrane-targeting sesquiterpenoid, on Streptococcus mutans physiology and survival within mixed-species oral biofilms. | International journal of oral science 20110401 |
| Drimenol: A versatile synthon for compounds with trans-drimane skeleton. | Natural product communications 20110401 |
| Farnesol as antibiotics adjuvant in Staphylococcus epidermidis control in vitro. | The American journal of the medical sciences 20110301 |
| Electrohydrodynamic deposition of nanotitanium doped hydroxyapatite coating for medical and dental applications. | Journal of materials science. Materials in medicine 20110301 |
| Chemoprevention of hepatocellular carcinoma. Proof of concept in animal models. | Acta gastro-enterologica Belgica 20110301 |
| Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis. | FEBS letters 20110204 |
| Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: a new drug combination for cancer therapy. | International journal of cancer 20110201 |
| In vitro and in vivo activity of three sesquiterpenes against L(3) larvae of Anisakis type I. | Experimental parasitology 20110201 |
| The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell death. | Eukaryotic cell 20110201 |
| Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. | Acta oncologica (Stockholm, Sweden) 20110101 |
| Composite fiber structures with antiproliferative agents exhibit advantageous drug delivery and cell growth inhibition in vitro. | Journal of pharmaceutical sciences 20110101 |
| Linking quorum sensing regulation and biofilm formation by Candida albicans. | Methods in molecular biology (Clifton, N.J.) 20110101 |
| The influence of additives on the nanoscopic dynamics of the phospholipid dimyristoylphosphatidylcholine. | Biochimica et biophysica acta 20110101 |
| Alkynyl-farnesol reporters for detection of protein S-prenylation in cells. | Molecular bioSystems 20110101 |
| Development of a novel PPARγ ligand screening system using pinpoint fluorescence-probed protein. | Bioscience, biotechnology, and biochemistry 20110101 |
| The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy. | PloS one 20110101 |
| Ras inhibition induces insulin sensitivity and glucose uptake. | PloS one 20110101 |
| Bisbibenzyls, a new type of antifungal agent, inhibit morphogenesis switch and biofilm formation through upregulation of DPP3 in Candida albicans. | PloS one 20110101 |
| Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione. | PloS one 20110101 |
| The combined treatment of Copaxone and Salirasib attenuates experimental autoimmune encephalomyelitis (EAE) in mice. | Journal of neuroimmunology 20101215 |
| Immunotoxicity activity of the major essential oil of Filipendula glaberrima against Aedes aegypti L. | Immunopharmacology and immunotoxicology 20101201 |
| The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance. | Fungal genetics and biology : FG & B 20101201 |
| Allergic contact dermatitis caused by farnesol: clinical relevance. | Cutaneous and ocular toxicology 20101201 |
| Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response. | Molecular microbiology 20101201 |
| Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane. | Biophysical journal 20101117 |
| Separation of attogram terpenes by the capillary zone electrophoresis with fluorometric detection. | Journal of chromatography. A 20101112 |
| Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins. | The Journal of biological chemistry 20101105 |
| Ultra high performance liquid chromatography tandem mass spectrometry analysis of quorum-sensing molecules of Candida albicans. | Journal of pharmaceutical and biomedical analysis 20101102 |
| In vitro pro- and anti-inflammatory responses to viable Candida albicans yeasts by a murine macrophage cell line. | Medical mycology 20101101 |
| Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis. | Plant physiology 20101101 |
| Farnesol, a potential efflux pump inhibitor in Mycobacterium smegmatis. | Molecules (Basel, Switzerland) 20101029 |
| Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. | Biotechnology and bioengineering 20101015 |
| Candida albicans cell wall components and farnesol stimulate the expression of both inflammatory and regulatory cytokines in the murine RAW264.7 macrophage cell line. | FEMS immunology and medical microbiology 20101001 |
| Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains. | Microbiology (Reading, England) 20101001 |
| The quorum-sensing molecule E,E-farnesol--its variable secretion and its impact on the growth and metabolism of Candida species. | Yeast (Chichester, England) 20100901 |
| Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase. | Cell research 20100801 |
| 2,3-Dihydrohomofarnesal: female sex attractant pheromone component of Callosobruchus rhodesianus (Pic). | Journal of chemical ecology 20100801 |
| Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas. | Molecular cancer therapeutics 20100801 |
| Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus. | Molecular microbiology 20100601 |
| Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation. | American journal of physiology. Cell physiology 20100601 |
| Salirasib in the treatment of pancreatic cancer. | Future oncology (London, England) 20100601 |
| Ras inhibits endoplasmic reticulum stress in human cancer cells with amplified Myc. | International journal of cancer 20100515 |
| Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents. | Bioorganic & medicinal chemistry 20100515 |
| Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway. | Eukaryotic cell 20100401 |
| Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. | Bioorganic & medicinal chemistry 20100401 |
| Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. | Chemico-biological interactions 20100330 |
| Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. | Biochemical pharmacology 20100301 |
| Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene omega-hydroxylase CYP4C7. | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20100201 |
| Molecular mechanisms involved in farnesol-induced apoptosis. | Cancer letters 20100128 |
| Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. | Oncogene 20100121 |
| The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat. | Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20100101 |
| Farnesol-modified biodegradable polyurethanes for cartilage tissue engineering. | Journal of biomedical materials research. Part A 20100101 |
| Phase 1 first-in-human clinical study of S-trans,trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors. | Cancer chemotherapy and pharmacology 20100101 |
| In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101 |
| Farnesol induces apoptosis and oxidative stress in the fungal pathogen Penicillium expansum. | Mycologia 20100101 |
| Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition. | Molecular cancer 20100101 |
| Cellular interactions of farnesol, a quorum-sensing molecule produced by Candida albicans. | Future microbiology 20091201 |
| Acid-catalyzed cyclization of terpenes under homogeneous and heterogeneous conditions as probed through stereoisotopic studies: a concerted process with competing preorganized chair and boat transition states. | Chemistry (Weinheim an der Bergstrasse, Germany) 20091109 |
| The effects of farnesol on Staphylococcus aureus biofilms and osteoblasts. An in vitro study. | The Journal of bone and joint surgery. American volume 20091101 |
| Effects of cholesterol and nuclear hormone receptor agonists on the production of transforming growth factor-beta in macrophages. | Bulletin of experimental biology and medicine 20090901 |
| Ras inhibition increases the frequency and function of regulatory T cells and attenuates type-1 diabetes in non-obese diabetic mice. | European journal of pharmacology 20090815 |
| Effect of farnesol on planktonic and biofilm cells of Staphylococcus epidermidis. | Current microbiology 20090801 |
| Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors. | Cardiovascular research 20090801 |
| Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis. | Life sciences 20090731 |
| The Ras inhibitor farnesylthiosalicyclic acid (FTS) prevents nodule formation and development of preneoplastic foci of altered hepatocytes in rats. | European journal of cancer (Oxford, England : 1990) 20090701 |
| Alkaline pH enhances farnesol production by Saccharomyces cerevisiae. | Journal of bioscience and bioengineering 20090701 |
| A two-component female-produced pheromone of the spider Pholcus beijingensis. | Journal of chemical ecology 20090701 |
| Novel farnesylthiosalicylate (FTS)-eluting composite structures. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090628 |
| Farnesol-induced apoptosis in Candida albicans. | Antimicrobial agents and chemotherapy 20090601 |
| Suppression of anti-Candida activity of macrophages by a quorum-sensing molecule, farnesol, through induction of oxidative stress. | Microbiology and immunology 20090601 |
| Ras inhibition attenuates myocardial ischemia-reperfusion injury. | Biochemical pharmacology 20090515 |
| Proteomic analysis of human low-density lipoprotein reveals the presence of prenylcysteine lyase, a hydrogen peroxide-generating enzyme. | Proteomics 20090301 |
| Biofilm formation by Pneumocystis spp. | Eukaryotic cell 20090201 |
| Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human beta-defensin 2 production. | Cytokine 20090201 |
| New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models. | Journal of medicinal chemistry 20090108 |
| Prenyl alcohol production by expression of exogenous isopentenyl diphosphate isomerase and farnesyl diphosphate synthase genes in Escherichia coli. | Bioscience, biotechnology, and biochemistry 20090101 |
| Antimicrobial effect of farnesol, a Candida albicans quorum sensing molecule, on Paracoccidioides brasiliensis growth and morphogenesis. | Annals of clinical microbiology and antimicrobials 20090101 |
| Lipid signaling in pathogenic fungi. | Annual review of microbiology 20090101 |
| Recovery of E,E-farnesol from cultures of yeast erg9 mutants: extraction with polymeric beads and purification by normal-phase chromatography. | Biotechnology progress 20090101 |
| [Biofilm caused by fungi--structure, quorum sensing, morphogenetic changes, resistance to drugs]. | Wiadomosci parazytologiczne 20090101 |
| Naturally occurring molecules as alternative therapeutic agents against cariogenic biofilms. | Advances in dental research 20090101 |
| Farnesol inhibits cell proliferation and induces apoptosis after partial hepatectomy in rats. | Acta cirurgica brasileira 20090101 |
| Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms. | BMC microbiology 20090101 |
| Effects of two terpene alcohols on the antibacterial activity and the mode of action of farnesol against Staphylococcus aureus. | Molecules (Basel, Switzerland) 20081209 |
| Benzo(a)pyrene-induced genotoxicity: attenuation by farnesol in a mouse model. | Journal of enzyme inhibition and medicinal chemistry 20081201 |
| [Quorum sensing in fungal pathogenesis]. | Nihon rinsho. Japanese journal of clinical medicine 20081201 |
| Farnesol ameliorates massive inflammation, oxidative stress and lung injury induced by intratracheal instillation of cigarette smoke extract in rats: an initial step in lung chemoprevention. | Chemico-biological interactions 20081125 |
| Fragrance material review on farnesol. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081101 |
| Salirasib (farnesyl thiosalicylic acid) for brain tumor treatment: a convection-enhanced drug delivery study in rats. | Molecular cancer therapeutics 20081101 |
| Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase. | Molecular microbiology 20081001 |
| Accumulation of prenyl alcohols by terpenoid biosynthesis inhibitors in various microorganisms. | Applied microbiology and biotechnology 20080901 |
| Farnesol, a fungal quorum-sensing molecule triggers apoptosis in human oral squamous carcinoma cells. | Neoplasia (New York, N.Y.) 20080901 |
| Various oils and detergents enhance the microbial production of farnesol and related prenyl alcohols. | Journal of bioscience and bioengineering 20080901 |
| Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency. | Pediatric research 20080801 |
| Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARgamma. | Cancer investigation 20080801 |
| Rapid antibacterial activity of 2 novel hand soaps: evaluation of the risk of development of bacterial resistance to the antibacterial agents. | Infection control and hospital epidemiology 20080801 |
| Analytical method for determination of allylic isoprenols in rat tissues by liquid chromatography/tandem mass spectrometry following chemical derivatization with 3-nitrophtalic anhydride. | Journal of pharmaceutical and biomedical analysis 20080715 |
| Farnesol decreases serum triglycerides in rats: identification of mechanisms including up-regulation of PPARalpha and down-regulation of fatty acid synthase in hepatocytes. | Lipids 20080701 |
| Protective effects of farnesol against oral candidiasis in mice. | Microbiology and immunology 20080701 |
| Strategies to enhance the biological effects of fluoride on dental biofilms. | Advances in dental research 20080701 |
| [Chemical constituents from the seed of Chimonanthus praecox extracted by supercritical carbon dioxide]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080701 |
| Determination of salirasib (S-trans,trans-farnesylthiosalicylic acid) in human plasma using liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080615 |
| NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway. | The Journal of biological chemistry 20080613 |
| The effect of mutation of F87 on the properties of CYP102A1-CYP4C7 chimeras: altered regiospecificity and substrate selectivity. | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080601 |
| Candida albicans Tup1 is involved in farnesol-mediated inhibition of filamentous-growth induction. | Eukaryotic cell 20080601 |
| N-Ras or K-Ras inhibition increases the number and enhances the function of Foxp3 regulatory T cells. | European journal of immunology 20080601 |
| Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans. | Journal of medical microbiology 20080501 |
| Competition between native liver and graft in auxiliary liver transplantation in a rat model. | Transplantation proceedings 20080501 |
| Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. | The Journal of biological chemistry 20080411 |
| Zeolite NaY-promoted cyclization of farnesal: a short route to nanaimoal. | The Journal of organic chemistry 20080404 |
| The effect of Ras inhibition on the proliferation, apoptosis and matrix metalloproteases activity in rat hepatic stellate cells. | Digestive diseases and sciences 20080401 |
| Activation of TRPA1 by farnesyl thiosalicylic acid. | Molecular pharmacology 20080401 |
| Homofarnesals: female sex attractant pheromone components of the southern cowpea weevil, Callosobruchus chinensis. | Journal of chemical ecology 20080401 |
| Influence of farnesol on the morphogenesis of Aspergillus niger. | Journal of basic microbiology 20080401 |
| Two different mechanisms for adhesion of Gram-negative bacterium, Pseudomonas fluorescens LP6a, to an oil-water interface. | Colloids and surfaces. B, Biointerfaces 20080315 |
| Influence of heterocyclic and oxime-containing farnesol analogs on quorum sensing and pathogenicity in Candida albicans. | Bioorganic & medicinal chemistry 20080215 |
| Inhibition of Fusarium graminearum growth and development by farnesol. | FEMS microbiology letters 20080201 |
| Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. | Breast cancer research and treatment 20080101 |
| Inhibition of the Ras oncoprotein reduces proliferation of hepatocytes in vitro and in vivo in rats. | Clinical science (London, England : 1979) 20080101 |
| Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice. | Cancer chemotherapy and pharmacology 20080101 |
| Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis. | Molecular microbiology 20080101 |
| Inhibitors of chronically active ras: potential for treatment of human malignancies. | Recent patents on anti-cancer drug discovery 20080101 |
| The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer. | Methods in enzymology 20080101 |
| [Farnesol as a quorum-sensing molecule in Candida albicans]. | Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20080101 |
| Characterization of (E,E)-farnesol and its fatty acid esters from anal scent glands of nutria (Myocastor coypus) by gas chromatography-mass spectrometry and gas chromatography-infrared spectrometry. | Journal of chromatography. A 20070921 |
| Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion. | Cancer research 20070815 |
| Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum stress response. | Cancer research 20070815 |
| Sesquiterpene farnesol as a competitive inhibitor of lipase activity of Staphylococcus aureus. | FEMS microbiology letters 20070801 |
| Farnesol-mediated inhibition of Candida albicans yeast growth and rescue by a diacylglycerol analogue. | Yeast (Chichester, England) 20070801 |
| Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa. | Molecular microbiology 20070801 |
| Neuroprotective effects of the Ras inhibitor S-trans-trans-farnesylthiosalicylic acid, measured by diffusion-weighted imaging after traumatic brain injury in rats. | Journal of neurotrauma 20070801 |
| Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine. | The Plant journal : for cell and molecular biology 20070601 |
| The rice (E)-beta-caryophyllene synthase (OsTPS3) accounts for the major inducible volatile sesquiterpenes. | Phytochemistry 20070601 |
| Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid). | Molecular cancer therapeutics 20070601 |
| The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways. | Cell death and differentiation 20070501 |
| The effect of terpene concentrations on the skin penetration of diclofenac sodium. | International journal of pharmaceutics 20070420 |
| Gene expression signature of human cancer cell lines treated with the ras inhibitor salirasib (S-farnesylthiosalicylic acid). | Cancer research 20070401 |
| Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. | The Journal of pharmacology and experimental therapeutics 20070301 |
| Circadian rhythms in Neurospora crassa: clock mutant effects in the absence of a frq-based oscillator. | Genetics 20070301 |
| Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus. | The Journal of antimicrobial chemotherapy 20070301 |
| In vivo and in vitro anaerobic mating in Candida albicans. | Eukaryotic cell 20070301 |
| A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway. | The Journal of biological chemistry 20070216 |
| Effect of farnesol on Candida dubliniensis morphogenesis. | Letters in applied microbiology 20070201 |
| Evaluation of an alcohol-based surgical hand disinfectant containing a synergistic combination of farnesol and benzethonium chloride for immediate and persistent activity against resident hand flora of volunteers and with a novel in vitro pig skin model. | Infection control and hospital epidemiology 20070201 |
| Zoledronate inhibits endothelial cell adhesion, migration and survival through the suppression of multiple, prenylation-dependent signaling pathways. | Journal of thrombosis and haemostasis : JTH 20070101 |
| Angiotensin II-induced MAPK phosphorylation mediated by Ras and/or phospholipase C-dependent phosphorylations but not by protein kinase C phosphorylation in cultured rat vascular smooth muscle cells. | Pharmacology 20070101 |
| 3D-QSAR of fungal quorum-sensing inhibiting analogs of farnesol. | Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20070101 |
| Zoledronate inhibits alphavbeta3 and alphavbeta5 integrin cell surface expression in endothelial cells. | Endothelium : journal of endothelial cell research 20070101 |
| Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells. | The Journal of steroid biochemistry and molecular biology 20070101 |
| Transcriptional changes in Candida albicans Genes by both farnesol and high cell density at an early stage of morphogenesis in N-acetyl-D-glucosamine medium. | Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20070101 |
| Inhibitory activity of 1-farnesylpyridinium on the spatial control over the assembly of cell wall polysaccharides in Schizosaccharomyces pombe. | Journal of biochemistry 20061201 |
| Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance. | FEMS yeast research 20061101 |
| The retinoid-X receptor ortholog, ultraspiracle, binds with nanomolar affinity to an endogenous morphogenetic ligand. | The FEBS journal 20061101 |
| Structure of the human mitochondrial monoamine oxidase B: new chemical implications for neuroprotectant drug design. | Neurology 20061010 |
| Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells. | Molecular reproduction and development 20061001 |
| Production of tyrosol by Candida albicans biofilms and its role in quorum sensing and biofilm development. | Eukaryotic cell 20061001 |
| The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1. | Clinical cancer research : an official journal of the American Association for Cancer Research 20060915 |
| Efficacy of an alcohol-based healthcare hand rub containing synergistic combination of farnesol and benzethonium chloride. | International journal of hygiene and environmental health 20060901 |
| Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis. | Molecular cancer therapeutics 20060901 |
| Ras inhibition results in growth arrest and death of androgen-dependent and androgen-independent prostate cancer cells. | Biochemical pharmacology 20060814 |
| E2F1 identified by promoter and biochemical analysis as a central target of glioblastoma cell-cycle arrest in response to Ras inhibition. | International journal of cancer 20060801 |
| Using non-mammalian hosts to study fungal virulence and host defense. | Current opinion in microbiology 20060801 |
| In vitro synergistic effect of farnesol and human gingival cells against Candida albicans. | Yeast (Chichester, England) 20060715 |
| Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase. | Carcinogenesis 20060601 |
| Microparticles developed by electrohydrodynamic atomization for the local delivery of anticancer drug to treat C6 glioma in vitro. | Biomaterials 20060601 |
| Anticancer effects of zoledronic acid against human osteosarcoma cells. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20060601 |
| Isolation and characterization of a monoamine oxidase B selective inhibitor from tobacco smoke. | Bioorganic & medicinal chemistry 20060515 |
| Functional characterization of the putative Aspergillus nidulans poly(ADP-ribose) polymerase homolog PrpA. | Genetics 20060501 |
| Farnesol prevents Fe-NTA-mediated renal oxidative stress and early tumour promotion markers in rats. | Human & experimental toxicology 20060501 |
| Farnesol induces thyroid hormone receptor (THR) beta1 but inhibits THR-mediated signaling in MCF-7 human breast cancer cells. | Biochemical and biophysical research communications 20060428 |
| Monitoring farnesol-induced toxicity in tobacco BY-2 cells with a fluorescent analog. | Archives of biochemistry and biophysics 20060415 |
| Farnesylthiosalicylic acid induces caspase activation and apoptosis in glioblastoma cells. | Cell death and differentiation 20060401 |
| Talking to themselves: autoregulation and quorum sensing in fungi. | Eukaryotic cell 20060401 |
| Farnesol restores wild-type colony morphology to 96% of Candida albicans colony morphology variants recovered following treatment with mutagens. | Genome 20060401 |
| 3-Farnesyl-2-hydroxybenzoic acid is a new anti-Helicobacter pylori compound from Piper multiplinervium. | Journal of ethnopharmacology 20060220 |
| Farnesol-induced apoptosis in Aspergillus nidulans reveals a possible mechanism for antagonistic interactions between fungi. | Molecular microbiology 20060201 |
| A soluble form of phosphatase in Saccharomyces cerevisiae capable of converting farnesyl diphosphate into E,E-farnesol. | Applied biochemistry and biotechnology 20060201 |
| Farnesylthiosalicylic acid: inhibition of proliferation and enhancement of apoptosis of hormone-dependent breast cancer cells. | Anti-cancer drugs 20060101 |
| Hitting Ras where it counts: Ras antagonism in the basolateral amygdala inhibits long-term fear memory. | The European journal of neuroscience 20060101 |
| Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma. | American journal of nephrology 20060101 |
| Ras antagonist inhibits growth and chemosensitizes human epithelial ovarian cancer cells. | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101 |
| Using inhibitors of prenylation to block localization and transforming activity. | Methods in enzymology 20060101 |
| Use of the Porcine Intestinal Epithelium (PIE)-Assay to analyze early stages of colonization by the human fungal pathogen Candida albicans. | Journal of basic microbiology 20060101 |
| Induction of apoptosis by lipophilic activators of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha). | The Biochemical journal 20051215 |
| Farnesylthiosalicylic acid blocks mammalian target of rapamycin signaling in breast cancer cells. | International journal of cancer 20051210 |
| Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation. | Biochemical pharmacology 20051205 |
| Enhanced pathogenicity of Candida albicans pre-treated with subinhibitory concentrations of fluconazole in a mouse model of disseminated candidiasis. | The Journal of antimicrobial chemotherapy 20051201 |
| Inhibition of Ras attenuates the course of experimental autoimmune neuritis. | Journal of neuroimmunology 20051101 |
| Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries. | Journal of dental research 20051101 |
| Synthesis of farnesol isomers via a modified Wittig procedure. | Organic letters 20051027 |
| Enhanced apoptosis through farnesol inhibition of phospholipase D signal transduction. | The FEBS journal 20051001 |
| Candida albicans-conditioned medium protects yeast cells from oxidative stress: a possible link between quorum sensing and oxidative stress resistance. | Eukaryotic cell 20051001 |
| Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol. | Alcoholism, clinical and experimental research 20050901 |
| SMGA gels for the skin permeation of haloperidol. | Journal of controlled release : official journal of the Controlled Release Society 20050818 |
| The inhibition of human mesangial cell proliferation by S-trans, trans-farnesylthiosalicylic acid. | Kidney international 20050801 |
| The effect of farnesol on amino acid incorporation by a wild-type and cell-wall variant strain of Candida albicans. | Canadian journal of microbiology 20050801 |
| Effects of farnesol on the physical properties of DMPC membranes. | Biochimica et biophysica acta 20050715 |
| Cell cycle dynamics and quorum sensing in Candida albicans chlamydospores are distinct from budding and hyphal growth. | Eukaryotic cell 20050701 |
| Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth. | Eukaryotic cell 20050701 |
| Getting at MYC through RAS. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050615 |
| Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050615 |
| A novel method to control the balance of skin microflora. Part 1. Attack on biofilm of Staphylococcus aureus without antibiotics. | Journal of dermatological science 20050601 |
| A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin. | Journal of dermatological science 20050601 |
| Biologically active fluorescent farnesol analogs. | Chemistry & biology 20050601 |
| Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. | The Journal of biological chemistry 20050422 |
| Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol. | Chemico-biological interactions 20050415 |
| Phenotype switching affects biofilm formation by Candida parapsilosis. | Microbiology (Reading, England) 20050401 |
| Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix. | Contact dermatitis 20050401 |
| Patch testing with a new fragrance mix - reactivity to the individual constituents and chemical detection in relevant cosmetic products. | Contact dermatitis 20050401 |
| Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase. | The Biochemical journal 20050215 |
| Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. | Cancer research 20050201 |
| Cytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract. | Toxicology and applied pharmacology 20050115 |
| Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. | The EMBO journal 20050112 |
| Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex. | Molecular endocrinology (Baltimore, Md.) 20050101 |
| Characterization of the regulation and functional consequences of p21ras activation in neutrophils by antineutrophil cytoplasm antibodies. | Journal of the American Society of Nephrology : JASN 20050101 |
| Partial morphological and functional characterization of the corpus allatum-corpus cardiacum complex from the two-spotted stinkbug, Perillus bioculatus (Hemiptera: Pentatomidae). | In vitro cellular & developmental biology. Animal 20050101 |
| Farnesol and geranylgeraniol modulate the structural properties of phosphatidylethanolamine model membranes. | Molecular membrane biology 20050101 |
| Antiphospholipid antibodies, thrombin and LPS activate brain endothelial cells and Ras-dependent pathways through distinct mechanisms. | Immunobiology 20050101 |
| Alleviation of free radical mediated oxidative and genotoxic effects of cadmium by farnesol in Swiss albino mice. | Redox report : communications in free radical research 20050101 |
| Farnesol is glucuronidated in human liver, kidney and intestine in vitro, and is a novel substrate for UGT2B7 and UGT1A1. | The Biochemical journal 20041215 |
| A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology. | Molecular microbiology 20041201 |
| Alternative farnesoid structures induce different conformational outcomes upon the Drosophila ortholog of the retinoid X receptor, ultraspiracle. | Insect biochemistry and molecular biology 20041101 |
| Likonides A and B: new ansa farnesyl quinols from the marine sponge Hyatella sp. | Organic letters 20041028 |
| Activated H-Ras regulates hematopoietic cell survival by modulating Survivin. | Biochemical and biophysical research communications 20041015 |
| The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action. | FEMS microbiology letters 20040815 |
| The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. | Journal of neurochemistry 20040801 |
| Treatment of thioacetamide-induced liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid. | Journal of hepatology 20040801 |
| The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans. | Eukaryotic cell 20040801 |
| Omega-hydroxylation of farnesol by mammalian cytochromes p450. | Biochimica et biophysica acta 20040601 |
| Absolute configuration of chiral terpenes in marking pheromones of bumblebees and cuckoo bumblebees. | Chirality 20040505 |
| Farnesol, a morphogenetic autoregulatory substance in the dimorphic fungus Candida albicans, inhibits hyphae growth through suppression of a mitogen-activated protein kinase cascade. | Biological & pharmaceutical bulletin 20040501 |
| Farnesol-DMPC phase behaviour: a (2)H-NMR study. | Biochimica et biophysica acta 20040309 |
| The novel Ras antagonist, farnesylthiosalicylate, suppresses growth of prostate cancer in vitro. | The Prostate 20040301 |
| Host plant volatiles synergize response to sex pheromone in codling moth, Cydia pomonella. | Journal of chemical ecology 20040301 |
| Contact allergy to farnesol in 2021 consecutively patch tested patients. Results of the IVDK. | Contact dermatitis 20040301 |
| Chimeragenesis of the fatty acid binding site of cytochrome P450BM3. Replacement of residues 73-84 with the homologous residues from the insect cytochrome P450 CYP4C7. | Biochemistry 20040224 |
| Restoration of sensitivity to anoikis in Ras-transformed rat intestinal epithelial cells by a Ras inhibitor. | Cell death and differentiation 20040201 |
| Inhibition of intimal thickening in the rat carotid artery injury model by a nontoxic Ras inhibitor. | Arteriosclerosis, thrombosis, and vascular biology 20040201 |
| Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. | Developmental cell 20040201 |
| Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. | Biochemical pharmacology 20040115 |
| Lipid metabolism in zebrafish. | Methods in cell biology 20040101 |
| Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells. | Cancer letters 20031230 |
| Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. | The Journal of biological chemistry 20031226 |
| Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit. | The Biochemical journal 20031201 |
| Increase in peripheral benzodiazepine receptors and loss of glutamate NMDA receptors in a mouse model of closed head injury: a quantitative autoradiographic study. | NeuroImage 20031201 |
| Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. | The Journal of antimicrobial chemotherapy 20031101 |
| New polyoxygenated farnesylcyclohexenones, deacetoxyyanuthone A and its hydro derivative from the marine-derived fungus Penicillium sp. | Journal of natural products 20031101 |
| Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase. | European journal of biochemistry 20031001 |
| Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. | Basic research in cardiology 20030901 |
| Circadian rhythms in Neurospora crassa: farnesol or geraniol allow expression of rhythmicity in the otherwise arrhythmic strains frq10, wc-1, and wc-2. | Journal of biological rhythms 20030801 |
| Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs. | Chemistry & biology 20030801 |
| Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. | Cellular signalling 20030701 |
| Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030701 |
| Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis. | Lipids 20030701 |
| Detection of farnesyl diphosphate accumulation in yeast ERG9 mutants. | Analytical biochemistry 20030615 |
| The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane domain. | Archives of biochemistry and biophysics 20030615 |
| Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells. | International journal of cancer 20030610 |
| Juvenile hormone biosynthesis in moths: synthesis and evaluation of farnesol homologs as alternate substrates of farnesol oxidase. | Insect biochemistry and molecular biology 20030601 |
| New approaches to the understanding of tamoxifen action and resistance. | Endocrine-related cancer 20030601 |
| The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20030601 |
| Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. | Cellular and molecular life sciences : CMLS 20030601 |
| The adenosine inhibition of glutamate exocytosis in synaptosomes is removed by the collapse of the vesicle-cytosol deltapH plus the opening of farnesol-sensitive Ca(2+) channels. | Cell calcium 20030401 |
| Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis. | Journal of the American Society of Nephrology : JASN 20030401 |
| Identification of pheromones and optimization of bait composition for click beetle pests (Coleoptera: Elateridae) in Central and Western Europe. | Pest management science 20030401 |
| Farnesylamine from the ant Monomorium fieldi Forel. | Journal of natural products 20030301 |
| Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro. | Calcified tissue international 20030201 |
| Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes. | Journal of lipid research 20030101 |
| Farnesyl thiosalicylic acid chemosensitizes human melanoma in vivo. | The Journal of investigative dermatology 20030101 |
| Inhibition of ras by farnesylthiosalicylate significantly reduces the levels of autoantibodies in two animal models of the antiphospholipid syndrome. | Immunobiology 20030101 |
| Farnesol for aerosol inhalation: nebulization and activity against human lung cancer cells. | Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20030101 |
| Chemical ecology of oribatid mites III. Chemical composition of oil gland exudates from two oribatid mites, Trhypochthoniellus sp. and Trhypochthonius japonicus (Acari: Trhypochthoniidae). | Experimental & applied acarology 20030101 |
| Evidence for the presence of the Kennedy and Bremer- Greenberg pathways in Caenorhabditis elegans. | Acta biochimica Polonica 20030101 |
| The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-beta-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage. | Plant physiology 20021201 |
| Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. | Oral microbiology and immunology 20021201 |
| Protein farnesyltransferase and protein prenylation in Plasmodium falciparum. | The Journal of biological chemistry 20021101 |
| Evidence for Ras-dependent signal transduction in phenytoin teratogenicity. | Toxicology and applied pharmacology 20021101 |
| Treatment of the chronic inflammation in peripheral target tissue improves the crushed nerve recovery in the rat: histopathological assessment of the nerve recovery. | Journal of the neurological sciences 20021015 |
| Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. | Arthritis and rheumatism 20021001 |
| Solution- and solid-phase synthesis of the polybasic lipid-modified C termini of Rho A and K-Ras 4B. | Chembiochem : a European journal of chemical biology 20020902 |
| African elephant sesquiterpenes. II. Identification and synthesis of new derivatives of 2,3-dihydrofarnesol. | Journal of natural products 20020901 |
| TGFbeta regulates the expression of G alpha(i2) via an effect on the localization of ras. | Journal of molecular and cellular cardiology 20020901 |
| Alpha-phosphono lactone analogues of farnesyl pyrophosphate: an asymmetric synthesis via ring-closing metathesis. | The Journal of organic chemistry 20020809 |
| Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells. | Anti-cancer drugs 20020801 |
| Actions of farnesol and xylitol against Staphylococcus aureus. | Chemotherapy 20020701 |
| Functional inhibition of Ras by S-trans,trans-farnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice. | Circulation 20020521 |
| Farnesol as an inhibitor and substrate for rabbit liver microsomal P450 enzymes. | Biochemical and biophysical research communications 20020426 |
| Effects of allatotropin and allatostatin on in vitro production of juvenile hormones by the corpora allata of virgin females of the moths of Heliothis virescens and Manduca sexta. | Peptides 20020401 |
| Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects. | International journal of cancer 20020401 |
| A general stereocontrolled, convergent synthesis of oligoprenols that parallels the biosynthetic pathway. | Journal of the American Chemical Society 20020320 |
| Farnesylpyridinium, an analog of isoprenoid farnesol, induces apoptosis but suppresses apoptotic body formation in human promyelocytic leukemia cells. | FEBS letters 20020313 |
| Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes. | FEBS letters 20020313 |
| The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance. | Clinical cancer research : an official journal of the American Association for Cancer Research 20020201 |
| Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells. | Lipids 20020201 |
| [Oleylamine (long-chain fatty amine)-induced cell death through MAP kinase pathways in human pancreatic cancer cells]. | [Hokkaido igaku zasshi] The Hokkaido journal of medical science 20020101 |
| Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis. | Biological research 20020101 |
| Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis. | Cancer detection and prevention 20020101 |
| Effects of the isoprenoids perillyl alcohol and farnesol on apoptosis biomarkers in pancreatic cancer chemoprevention. | Anticancer research 20020101 |
| Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS). | Clinical and experimental immunology 20011201 |
| Impairment by lovastatin of neural relaxation of the rabbit sphincter of Oddi. | European journal of pharmacology 20011130 |
| The Ras-pathway inhibitor, S-trans-trans-farnesylthiosalicylic acid, suppresses experimental allergic encephalomyelitis. | Journal of neuroimmunology 20011101 |
| Inhibition effect of new farnesol derivatives on all-trans-retinoic acid metabolism. | Metabolism: clinical and experimental 20011101 |
| Requirement of c-jun N-terminal kinase for apoptotic cell death induced by farnesyltransferase inhibitor, farnesylamine, in human pancreatic cancer cells. | Biochemical and biophysical research communications 20011019 |
| (+)-epi-Alpha-bisabolol [correction of bisbolol] is the wound-healing principle of Peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids. | Journal of natural products 20011001 |
| Role of G proteins and modulation of p38 MAPK activation in the protection by nitric oxide against ischemia-reoxygenation injury. | Biochemical and biophysical research communications 20010907 |
| Effect of perillic acid, a putative isoprenylation inhibitor, on the cultured rat lens. | Experimental eye research 20010801 |
| Partial characterization of farnesyl and geranylgeranyl diphosphatases induced in rice seedlings by UV-C irradiation. | Plant & cell physiology 20010801 |
| Uncoupling farnesol-induced apoptosis from its inhibition of phosphatidylcholine synthesis. | The Journal of biological chemistry 20010706 |
| Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by dual activation of the ras-phosphoinositide 3-kinase and jun n-terminal kinase pathways. | The Journal of biological chemistry 20010615 |
| Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets. | The Journal of biological chemistry 20010511 |
| Stereochemical analysis of the reaction catalyzed by human protein geranylgeranyl transferase. | Biochemistry 20010403 |
| Farnesol oxidation in insects: evidence that the biosynthesis of insect juvenile hormone is mediated by a specific alcohol oxidase. | Insect biochemistry and molecular biology 20010201 |
| Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase. | The Journal of biological chemistry 20010126 |
| The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. | Biochemical and biophysical research communications 20000402 |
| Farnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactions. | Proceedings of the National Academy of Sciences of the United States of America 19991109 |
| The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. | Cancer research 19981201 |
| Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue. | Biochemistry 19981124 |
| Dislodgment and accelerated degradation of Ras. | Biochemistry 19980203 |
| Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells. | Biochimica et biophysica acta 19971030 |
| N-(arylalkyl)farnesylamines: new potent squalene synthetase inhibitors. | Journal of medicinal chemistry 19930514 |
| Amidinium cation as a mimic of allylic carbocation: synthesis and squalene synthetase inhibitory activity of an amidinium analog of a carbocation intermediate. | Journal of medicinal chemistry 19930305 |
| The gamma subunit of transducin is farnesylated. | Proceedings of the National Academy of Sciences of the United States of America 19901001 |
| Squalene synthetase. | Molecular and cellular biochemistry 19791015 |
| Biodegradation of acyclic isoprenoids by Pseudomonas species. | Journal of bacteriology 19780801 |
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