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158985-08-1 | 3-[[4-(4-Iodophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine
CAS No: 158985-08-1 Catalog No: AG00AMIV MDL No:
Product Description
Catalog Number:
AG00AMIV
Chemical Name:
3-[[4-(4-Iodophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine
CAS Number:
158985-08-1
IUPAC Name:
3-[[4-(4-iodophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine
InChI:
InChI=1S/C18H19IN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)
InChI Key:
OOEUHRGMLFVKQO-UHFFFAOYSA-N
Properties
Complexity:
377
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
418.065g/mol
Formal Charge:
0
Heavy Atom Count:
23
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
418.282g/mol
Monoisotopic Mass:
418.065g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
35.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.4
Literature
| Title | Journal |
|---|---|
| Amphetamines induce tissue factor and impair tissue factor pathway inhibitor: role of dopamine receptor type 4. | European heart journal 20100701 |
| Three amino acids in the D2 dopamine receptor regulate selective ligand function and affinity. | Journal of neurochemistry 20090701 |
| Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: preventive and therapeutic effects on experimental autoimmune encephalomyelitis. | Biochemical and biophysical research communications 20080822 |
| Role of postsynaptic serotonin1A receptors in risperidone-induced increase in acetylcholine release in rat prefrontal cortex. | European journal of pharmacology 20070322 |
| Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060701 |
| Reciprocal mutations in TM2/TM3 in a D2 dopamine receptor background confirms the importance of this microdomain as a selective determinant of para-halogenated 1,4-disubstituted aromatic piperazines. | Archiv der Pharmazie 20050601 |
| Synthesis and evaluation of fluorine-substituted 1H-pyrrolo[2,3-b]pyridine derivatives for dopamine D4 receptor imaging. | Bioorganic & medicinal chemistry 20041101 |
| Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina. | Neuropharmacology 20030601 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Dopamine D4 receptor activation inhibits presynaptically glutamatergic neurotransmission in the rat supraoptic nucleus. | Journal of neurophysiology 20010901 |
| Nonconserved residues in the second transmembrane-spanning domain of the D(4) dopamine receptor are molecular determinants of D(4)-selective pharmacology. | Molecular pharmacology 20000101 |
| Identification and pharmacological characterization of [125I]L-750,667, a novel radioligand for the dopamine D4 receptor. | Molecular pharmacology 19961201 |
| 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. | Journal of medicinal chemistry 19960510 |
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