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157604-55-2 | 3-Piperidinecarboxylic acid, 1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-, (3S)-
CAS No: 157604-55-2 Catalog No: AG001PKG MDL No:
Product Description
Catalog Number:
AG001PKG
Chemical Name:
3-Piperidinecarboxylic acid, 1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-, (3S)-
CAS Number:
157604-55-2
Molecular Formula:
C30H35NO6
Molecular Weight:
505.6020
IUPAC Name:
(3S)-1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acid
InChI:
InChI=1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m0/s1
InChI Key:
VDLDUZLDZBVOAS-QFIPXVFZSA-N
SMILES:
COc1ccc(cc1)C(c1ccc(cc1)OC)(c1ccc(cc1)OC)OCCN1CCC[C@@H](C1)C(=O)O
Properties
Complexity:
620
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
505.246g/mol
Formal Charge:
0
Heavy Atom Count:
37
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
505.611g/mol
Monoisotopic Mass:
505.246g/mol
Rotatable Bond Count:
11
Topological Polar Surface Area:
77.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.4
Literature
| Title | Journal |
|---|---|
| GABA transporter subtype 1 and GABA transporter subtype 3 modulate glutamatergic transmission via activation of presynaptic GABA(B) receptors in the rat globus pallidus. | The European journal of neuroscience 20120801 |
| Development of an (S)-1-{2-[tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [(S)-SNAP-5114] carba analogue inhibitor for murine γ-aminobutyric acid transporter type 4. | ChemMedChem 20120701 |
| Intracellular Na+ concentration influences short-term plasticity of glutamate transporter-mediated currents in neocortical astrocytes. | Glia 20120401 |
| Aminomethyltetrazoles as potential inhibitors of the γ-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation. | Bioorganic & medicinal chemistry 20111101 |
| Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex. | Pain 20110601 |
| GABAB receptor-mediated tonic inhibition of noradrenergic A7 neurons in the rat. | Journal of neurophysiology 20110601 |
| Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors. | European journal of medicinal chemistry 20110501 |
| Differential localization and function of GABA transporters, GAT-1 and GAT-3, in the rat globus pallidus. | The European journal of neuroscience 20110401 |
| Intrinsic activation of GABA(A) receptors suppresses epileptiform activity in the cerebral cortex of immature mice. | Epilepsia 20100801 |
| Estimation of ambient GABA levels in layer I of the mouse neonatal cortex in brain slices. | The Journal of physiology 20100701 |
| Postdepolarization potentiation of GABAA receptors: a novel mechanism regulating tonic conductance in hippocampal neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100602 |
| Localization and function of GABA transporters in the globus pallidus of parkinsonian monkeys. | Experimental neurology 20100601 |
| Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship. | European journal of medicinal chemistry 20100601 |
| Role of GABA transporter 3 in GABAergic synaptic transmission at striatal output neurons. | Synapse (New York, N.Y.) 20091001 |
| Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs. | Journal of neurochemistry 20090501 |
| Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4. | European journal of medicinal chemistry 20081101 |
| Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2. | The Journal of biological chemistry 20070706 |
| GAT-3 transporters regulate inhibition in the neocortex. | Journal of neurophysiology 20051201 |
| Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortex. | Journal of neurophysiology 20050901 |
| GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transporters. | Journal of neurophysiology 20050801 |
| Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. | Receptors & channels 19940101 |
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