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157284-96-3 | 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-
CAS No: 157284-96-3 Catalog No: AG001PCX MDL No:
Product Description
Catalog Number:
AG001PCX
Chemical Name:
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-
CAS Number:
157284-96-3
Molecular Formula:
C24H34N4
Molecular Weight:
378.5536
IUPAC Name:
N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine
InChI:
InChI=1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3
InChI Key:
IXPROWGEHNVJOY-UHFFFAOYSA-N
SMILES:
CCCCN(c1nc(C)nc2c1c(C)c(n2c1c(C)cc(cc1C)C)C)CC
NSC Number:
715590
Properties
Complexity:
485
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
378.278g/mol
Formal Charge:
0
Heavy Atom Count:
28
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
378.564g/mol
Monoisotopic Mass:
378.278g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
34A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
6.6
Literature
| Title | Journal |
|---|---|
| Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function. | Psychoneuroendocrinology 20160401 |
| Differential effects of acute morphine, and chronic morphine-withdrawal on obsessive-compulsive behavior: inhibitory influence of CRF receptor antagonists on chronic morphine-withdrawal. | Neuropeptides 20121001 |
| Regulation of estradiol and progesterone production by CRH-R1 and -R2 is through divergent signaling pathways in cultured human placental trophoblasts. | Endocrinology 20121001 |
| CRH activation of different signaling pathways results in differential calcium signaling in human pregnant myometrium before and during labor. | The Journal of clinical endocrinology and metabolism 20121001 |
| Divergent roles of the CRH receptors in the control of gonadotropin secretion induced by acute restraint stress at proestrus. | Endocrinology 20121001 |
| Role of corticotropin-releasing hormone family peptides in androgen receptor and vitamin D receptor expression and translocation in human breast cancer MCF-7 cells. | European journal of pharmacology 20120605 |
| CRH-R1 and CRH-R2 differentially modulate dendritic outgrowth of hippocampal neurons. | Endocrine 20120601 |
| Loss of environmental enrichment increases vulnerability to cocaine addiction. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120601 |
| Corticotropin-releasing factor modulation of forebrain GABAergic transmission has a pivotal role in the expression of anabolic steroid-induced anxiety in the female mouse. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120501 |
| Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120307 |
| Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors. | Journal of neurochemistry 20120301 |
| Differential regulation of glucose transporters mediated by CRH receptor type 1 and type 2 in human placental trophoblasts. | Endocrinology 20120301 |
| The effects of corticotropin-releasing factor and the urocortins on hypothalamic gamma-amino butyric acid release--the impacts on the hypothalamic-pituitary-adrenal axis. | Neurochemistry international 20120301 |
| Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome. | Nature genetics 20120201 |
| Pathophysiology of the Behçet's Disease. | Pathology research international 20120101 |
| Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats. | Pharmacology, biochemistry, and behavior 20120101 |
| Lead diversification. Application to existing drug molecules: mifepristone 1 and antalarmin 8. | Bioorganic & medicinal chemistry letters 20120101 |
| Differential regulation of gonadotropin-releasing hormone by corticotropin-releasing factor family peptides in hypothalamic N39 cells. | Peptides 20120101 |
| Involvement of noradrenergic transmission in the PVN on CREB activation, TORC1 levels, and pituitary-adrenal axis activity during morphine withdrawal. | PloS one 20120101 |
| Corticotropin-releasing factor (CRF) receptor subtypes in mediating neuronal activation of brain areas involved in responses to intracerebroventricular CRF and stress in rats. | Peptides 20111201 |
| The CRH-R₁ receptor mediates luteinizing hormone, prolactin, corticosterone and progesterone secretion induced by restraint stress in estrogen-primed rats. | Brain research 20111103 |
| Effects of acute ethanol on corticotropin-releasing hormone and β-endorphin systems at the level of the rat central amygdala. | Psychopharmacology 20111101 |
| Expression of epidermal CAMP changes in parallel with permeability barrier status. | The Journal of investigative dermatology 20111101 |
| Effects of corticotropin-releasing hormone receptor antagonists on the ethanol-induced increase of dynorphin A1-8 release in the rat central amygdala. | Alcohol (Fayetteville, N.Y.) 20111101 |
| CRH acts on CRH-R1 and -R2 to differentially modulate the expression of large-conductance calcium-activated potassium channels in human pregnant myometrium. | Endocrinology 20111101 |
| Urocortin 1 inhibits guinea pig gallbladder contractility in vitro via corticotropin-releasing factor receptor 2. | Canadian journal of physiology and pharmacology 20111101 |
| Antagonizing corticotropin-releasing factor in the central nucleus of the amygdala attenuates fear-induced reductions in sleep but not freezing. | Sleep 20111101 |
| Corticotropin-releasing factor and noradrenergic signalling exert reciprocal control over startle reactivity. | The international journal of neuropsychopharmacology 20111001 |
| Effects of corticotropin releasing factor on spontaneous burst activity in the piriform-amygdala complex of in vitro brain preparations from newborn rats. | Neuroscience research 20111001 |
| Different effects of corticotropin-releasing factor and urocortin 2 on apoptosis of prostate cancer cells in vitro. | Journal of molecular endocrinology 20111001 |
| Augmented cocaine seeking in response to stress or CRF delivered into the ventral tegmental area following long-access self-administration is mediated by CRF receptor type 1 but not CRF receptor type 2. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110803 |
| Involvement of CRF2 receptor in the brain regions in restraint-induced anorexia. | Neuroreport 20110713 |
| Anxiety states induced by post-weaning social isolation are mediated by CRF receptors in the dorsal raphe nucleus. | Brain research bulletin 20110530 |
| Blockade of CRF1 and CCK2 receptors attenuated the elevated anxiety-like behavior induced by immobilization stress. | Pharmacology, biochemistry, and behavior 20110501 |
| Impaired CRH and urocortin expression and function in eutopic endometrium of women with endometriosis. | The Journal of clinical endocrinology and metabolism 20110401 |
| Corticotropin-releasing hormone inhibits in vitro oocyte maturation in mice. | Fertility and sterility 20110315 |
| CRF and urotensin I effects on aggression and anxiety-like behavior in rainbow trout. | The Journal of experimental biology 20110315 |
| Treatment with a CRH-R1 antagonist prevents stress-induced suppression of the central neural drive to the reproductive axis in female macaques. | American journal of physiology. Endocrinology and metabolism 20110101 |
| Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults. | PloS one 20110101 |
| The Neurological Ecology of Fear: Insights Neuroscientists and Ecologists Have to Offer one Another. | Frontiers in behavioral neuroscience 20110101 |
| A novel role of peripheral corticotropin-releasing hormone (CRH) on dermal fibroblasts. | PloS one 20110101 |
| Acupuncture Attenuates Anxiety-Like Behavior by Normalizing Amygdaloid Catecholamines during Ethanol Withdrawal in Rats. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
| Urocortin-1 within the centrally-projecting Edinger-Westphal nucleus is critical for ethanol preference. | PloS one 20110101 |
| Anorexia nervosa: a unified neurological perspective. | International journal of medical sciences 20110101 |
| Increase of core temperature induced by corticotropin-releasing factor and urocortin: a comparative study. | Regulatory peptides 20101210 |
| Corticotropin-releasing hormone-receptor 2 is required for acute stress-induced bladder vascular permeability and release of vascular endothelial growth factor. | BJU international 20101101 |
| Exploring the binding site crevice of a family B G protein-coupled receptor, the type 1 corticotropin releasing factor receptor. | Molecular pharmacology 20101001 |
| Reversal by quercetin of corticotrophin releasing factor induced anxiety- and depression-like effect in mice. | Progress in neuro-psychopharmacology & biological psychiatry 20100816 |
| Regulation of blood L-glutamate levels by stress as a possible brain defense mechanism. | Experimental neurology 20100801 |
| Effect of CRH on NO bioavailability, ROS production and antioxidant defense systems in endothelial EAhy926 cells. | Free radical research 20100701 |
| Involvement of microglial cells in infrasonic noise-induced stress via upregulated expression of corticotrophin releasing hormone type 1 receptor. | Neuroscience 20100519 |
| The serotonergic projection from the median raphe nucleus to the ventral hippocampus is involved in the retrieval of fear memory through the corticotropin-releasing factor type 2 receptor. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100501 |
| Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal. | Molecular pharmacology 20100501 |
| A specific CRH antagonist attenuates ACTH-stimulated cortisol secretion in ovine adrenocortical cells. | Reproductive sciences (Thousand Oaks, Calif.) 20100501 |
| Corticotropin-releasing hormone attenuates vascular endothelial growth factor release from human HaCaT keratinocytes. | Regulatory peptides 20100225 |
| Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100210 |
| Swim stress enhances nociceptin/orphanin FQ-induced inhibition of rat dorsal raphe nucleus activity in vivo and in vitro: role of corticotropin releasing factor. | Neuropharmacology 20100201 |
| Biological contribution to social influences on alcohol drinking: evidence from animal models. | International journal of environmental research and public health 20100201 |
| Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation. | Neuropharmacology 20100101 |
| Association between repeated unpredictable chronic mild stress (UCMS) procedures with a high fat diet: a model of fluoxetine resistance in mice. | PloS one 20100101 |
| The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum. | Genome biology 20100101 |
| Alternative strategies for the treatment of classical congenital adrenal hyperplasia: pitfalls and promises. | International journal of pediatric endocrinology 20100101 |
| The impact of stress on tumor growth: peripheral CRF mediates tumor-promoting effects of stress. | Molecular cancer 20100101 |
| Effects of antalarmin and nadolol on the relationship between social stress and pulmonary metastasis development in male OF1 mice. | Behavioural brain research 20091214 |
| Stress-induced potentiation of cocaine reward: a role for CRF R1 and CREB. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20091101 |
| Urocortin increases IL-4 and IL-10 secretion and reverses LPS-induced TNF-alpha release from human trophoblast primary cells. | American journal of reproductive immunology (New York, N.Y. : 1989) 20091001 |
| Endocrine, behavioral and autonomic effects of neuropeptide AF. | Hormones and behavior 20090601 |
| Nicotine suppresses energy storage through activation of sympathetic outflow to brown adipose tissue via corticotropin-releasing factor type 1 receptor. | Neuroscience letters 20090508 |
| Alanine scanning mutagenesis of the second extracellular loop of type 1 corticotropin-releasing factor receptor revealed residues critical for peptide binding. | Molecular pharmacology 20090401 |
| Activation of corticotropin-releasing factor receptor 2 in lateral septum negatively regulates maternal defense. | Behavioral neuroscience 20090401 |
| Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20090401 |
| Corticotropin releasing factor enhances attentional function as assessed by the five-choice serial reaction time task in rats. | Behavioural brain research 20090317 |
| Chronic stimulation of corticotropin-releasing factor receptor 1 enhances the anxiogenic response of the cholecystokinin system. | Molecular psychiatry 20090301 |
| Mechanisms of withdrawal-associated increases in heroin self-administration: pharmacologic modulation of heroin vs food choice in heroin-dependent rhesus monkeys. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090301 |
| Antidepressant efficacy screening of novel targets in the chick anxiety-depression model. | Behavioural pharmacology 20090301 |
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| Chronic mild stress (CMS) in mice: of anhedonia, 'anomalous anxiolysis' and activity. | PloS one 20090101 |
| A comparison of ligand based virtual screening methods and application to corticotropin releasing factor 1 receptor. | Journal of molecular graphics & modelling 20090101 |
| Inhibition of serotonin outflow by nociceptin/orphaninFQ in dorsal raphe nucleus slices from normal and stressed rats: Role of corticotropin releasing factor. | Neurochemistry international 20090101 |
| Consequences of post-weaning social isolation on anxiety behavior and related neural circuits in rodents. | Frontiers in behavioral neuroscience 20090101 |
| CRH-like peptides in human reproduction. | Current medicinal chemistry 20090101 |
| Breaching the blood-brain barrier as a gate to psychiatric disorder. | Cardiovascular psychiatry and neurology 20090101 |
| CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior. | PloS one 20090101 |
| Role of anxiety in the pathophysiology of irritable bowel syndrome: importance of the amygdala. | Frontiers in neuroscience 20090101 |
| Effects of antalarmin, a CRF receptor 1 antagonist, on fright reaction and endocrine stress response in crucian carp (Carassius carassius). | Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20081201 |
| Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20081201 |
| Footshock-induced urinary bladder hypersensitivity: role of spinal corticotropin-releasing factor receptors. | The journal of pain : official journal of the American Pain Society 20081101 |
| Involvement of CRH receptors in urocortin-induced hyperthermia. | Peptides 20081101 |
| Corticotropin-releasing hormone acts on CRH-R1 to inhibit the spontaneous contractility of non-labouring human myometrium at term. | Life sciences 20081024 |
| Corticotropin-releasing hormone stimulates SGK-1 kinase expression in cultured hippocampal neurons via CRH-R1. | American journal of physiology. Endocrinology and metabolism 20081001 |
| Neuropharmacology. | Indian journal of pharmacology 20081001 |
| Differential blockade of CRF-evoked behaviors by depletion of norepinephrine and serotonin in rats. | Psychopharmacology 20080901 |
| Antalarmin. | Acta crystallographica. Section E, Structure reports online 20080801 |
| Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats. | Psychopharmacology 20080701 |
| Corticotropin-releasing factor in the dorsal raphe nucleus increases medial prefrontal cortical serotonin via type 2 receptors and median raphe nucleus activity. | The European journal of neuroscience 20080701 |
| Integration of in vivo and in vitro approaches to characterize the toxicity of Antalarmin, a corticotropin-releasing hormone receptor antagonist. | Toxicology 20080603 |
| Differential regulation of prostaglandin production mediated by corticotropin-releasing hormone receptor type 1 and type 2 in cultured human placental trophoblasts. | Endocrinology 20080601 |
| Restraint stress and ethanol consumption in two mouse strains. | Alcoholism, clinical and experimental research 20080501 |
| Effects of corticotropin-releasing hormone and stresscopin on vascular endothelial growth factor mRNA expression in cultured early human extravillous trophoblasts. | Endocrine 20080401 |
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| Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens. | European journal of pharmacology 20080114 |
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| Stress-induced intracellular trafficking of corticotropin-releasing factor receptors in rat locus coeruleus neurons. | Endocrinology 20080101 |
| Enhanced intracellular calcium induced by urocortin is involved in degranulation of rat lung mast cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101 |
| The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats. | Psychopharmacology 20071201 |
| Endocrine and behavioral effects of neuromedin S. | Hormones and behavior 20071201 |
| Urocortin I is present in the enteric nervous system and exerts an excitatory effect via cholinergic and serotonergic pathways in the rat colon. | American journal of physiology. Gastrointestinal and liver physiology 20071001 |
| Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation. | American journal of physiology. Endocrinology and metabolism 20070901 |
| Allosteric modulators of class B G-protein-coupled receptors. | Current neuropharmacology 20070901 |
| Intratumoral CRH modulates immuno-escape of ovarian cancer cells through FasL regulation. | British journal of cancer 20070828 |
| Alleviation of the effects of endotoxin exposure on behavior and hippocampal IL-1beta by a selective non-peptide antagonist of corticotropin-releasing factor receptors. | Brain, behavior, and immunity 20070801 |
| Treatment with CRH-1 antagonist antalarmin reduces behavioral and endocrine responses to social stressors in marmosets (Callithrix kuhlii). | American journal of primatology 20070801 |
| Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts. | Endocrinology 20070801 |
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| Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout. | Pharmacology, biochemistry, and behavior 20070401 |
| Mechanisms involved in the anti-inflammatory action of inhaled tea tree oil in mice. | Experimental biology and medicine (Maywood, N.J.) 20070301 |
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| Involvement of the corticotropin-releasing factor (CRF) type 2 receptor in CRF-induced thyrotropin release by the amphibian pituitary gland. | General and comparative endocrinology 20070201 |
| Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glands. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20070201 |
| Evidence that corticotropin-releasing hormone inhibits cell growth of human breast cancer cells via the activation of CRH-R1 receptor subtype. | Molecular and cellular endocrinology 20070129 |
| Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats. | Biological psychiatry 20070101 |
| Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20061201 |
| Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function. | American journal of physiology. Regulatory, integrative and comparative physiology 20061201 |
| Effects of stress modulation on morphine-induced conditioned place preferences and plasma corticosterone levels in Fischer, Lewis, and Sprague-Dawley rat strains. | Psychopharmacology 20061201 |
| Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. | Psychopharmacology 20061201 |
| Evidence that corticotropin-releasing factor receptor type 1 couples to Gs- and Gi-proteins through different conformations of its J-domain. | British journal of pharmacology 20061201 |
| Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeys. | Pharmacology, biochemistry, and behavior 20061201 |
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| The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060906 |
| A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060601 |
| Impact of state of arousal and stress neuropeptides on urodynamic function in freely moving rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20060601 |
| The CRF1 receptor antagonist, antalarmin, reverses isolation-induced up-regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn-hooded rats. | The European journal of neuroscience 20060601 |
| Treatments in depression. | Dialogues in clinical neuroscience 20060601 |
| Corticotropin-releasing factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU.1 and AP-1. | Journal of immunology (Baltimore, Md. : 1950) 20060201 |
| The effects of corticoptropin-releasing factor and the urocortins on striatal dopamine release induced by electrical stimulation-an in vitro superfusion study. | Neurochemical research 20060201 |
| Corticotropin-releasing hormone modulates human trophoblast invasion through carcinoembryonic antigen-related cell adhesion molecule-1 regulation. | The American journal of pathology 20060101 |
| CRF1 receptors as a therapeutic target for irritable bowel syndrome. | Current pharmaceutical design 20060101 |
| Corticotropin-releasing hormone and urocortin induce secretion of matrix metalloproteinase-9 (MMP-9) without change in tissue inhibitors of MMP-1 by cultured cells from human placenta and fetal membranes. | The Journal of clinical endocrinology and metabolism 20051201 |
| Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists. | Journal of medicinal chemistry 20050908 |
| Chronic corticotropin-releasing factor type 1 receptor antagonism with antalarmin regulates the dopaminergic system of Fawn-Hooded rats. | Journal of neurochemistry 20050901 |
| Corticotropin-releasing hormone (CRH) and urocortin act through type 1 CRH receptors to stimulate dehydroepiandrosterone sulfate production in human fetal adrenal cells. | The Journal of clinical endocrinology and metabolism 20050901 |
| Role of corticotropin-releasing factor pathways in stress-related alterations of colonic motor function and viscerosensibility in female rodents. | Gender medicine 20050901 |
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| The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats. | Psychopharmacology 20050701 |
| Peripheral injection of sauvagine prevents repeated colorectal distension-induced visceral pain in female rats. | Peptides 20050701 |
| Potent, orally active corticotropin-releasing factor receptor-1 antagonists containing a tricyclic pyrrolopyridine or pyrazolopyridine core. | Journal of medicinal chemistry 20050616 |
| Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor. | Journal of immunology (Baltimore, Md. : 1950) 20050615 |
| Corticosterone implants to the amygdala and type 1 CRH receptor regulation: effects on behavior and colonic sensitivity. | Behavioural brain research 20050603 |
| Corticotropin-releasing factor 1 receptor-mediated mechanisms inhibit colonic hypersensitivity in rats. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20050601 |
| Reduced hypothalamic vasopressin secretion underlies attenuated adrenocorticotropin stress responses in pregnant rats. | Endocrinology 20050301 |
| Quantitative determination of antalarmin, a novel corticotropin-releasing hormone receptor-1 antagonist, in canine plasma by HPLC-MS. | Journal of separation science 20050301 |
| Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050101 |
| A CRH1 antagonist into the amygdala of mice prevents defeat-induced defensive behavior. | Annals of the New York Academy of Sciences 20041201 |
| Behavioral, adrenal, and sympathetic responses to long-term administration of an oral corticotropin-releasing hormone receptor antagonist in a primate stress paradigm. | The Journal of clinical endocrinology and metabolism 20041101 |
| Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice. | European journal of pharmacology 20040919 |
| Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures. | Journal of neuroimmunology 20040801 |
| Corticotropin-releasing hormone antagonists, astressin B and antalarmin: differing profiles of activity in rhesus monkeys. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040601 |
| Corticotropin-releasing hormone stimulates NF-kappaB in human epidermal keratinocytes. | The Journal of endocrinology 20040601 |
| Endometrial and placental CRH as regulators of human embryo implantation. | Journal of reproductive immunology 20040601 |
| Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists. | Biochemistry 20040406 |
| Corticotropin-releasing factor and urocortin differentially modulate rat Purkinje cell dendritic outgrowth and differentiation in vitro. | The European journal of neuroscience 20040401 |
| Reproductive functions of corticotropin-releasing hormone. Research and potential clinical utility of antalarmins (CRH receptor type 1 antagonists). | American journal of reproductive immunology (New York, N.Y. : 1989) 20040401 |
| Participation of maternal and fetal CRH in early phases of human implantation: the role of antalarmin. | Current drug targets. Immune, endocrine and metabolic disorders 20040301 |
| Selective activation of corticotropin-releasing factor-2 receptors on neurochemically identified neurons in the rat dorsal raphe nucleus reveals dual actions. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040211 |
| The effect of chronic CRF1 receptor blockade on the central CCK systems of Fawn-Hooded rats. | Regulatory peptides 20031115 |
| Uterine and embryonic trophoblast CRH promotes implantation and maintenance of early pregnancy. | Annals of the New York Academy of Sciences 20031101 |
| Maternal and fetal hypothalamic-pituitary-adrenal axes during pregnancy and postpartum. | Annals of the New York Academy of Sciences 20031101 |
| Increased depression-like behaviors in corticotropin-releasing factor receptor-2-deficient mice: sexually dichotomous responses. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030615 |
| Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice. | Progress in neuro-psychopharmacology & biological psychiatry 20030601 |
| Corticotropin-releasing factor (CRF) can directly affect brain microvessel endothelial cells. | Brain research 20030411 |
| Control by tachykinin NK(2) receptors of CRF(1) receptor-mediated activation of hippocampal acetylcholine release in the rat and guinea-pig. | Neuropeptides 20030401 |
| The emerging role of peripheral corticotropin-releasing hormone (CRH). | Journal of endocrinological investigation 20030401 |
| Mechanism of corticotropin-releasing factor type I receptor regulation by nonpeptide antagonists. | Molecular pharmacology 20030301 |
| Circuitry underlying regulation of the serotonergic system by swim stress. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030201 |
| The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review. | CNS drug reviews 20030101 |
| The CRF1 receptor antagonist antalarmin reduces volitional ethanol consumption in isolation-reared fawn-hooded rats. | Neuroscience 20030101 |
| Pediatric stress: hormonal mediators and human development. | Hormone research 20030101 |
| Neural immune pathways and their connection to inflammatory diseases. | Arthritis research & therapy 20030101 |
| Corticotropin-releasing hormone and brain mast cells regulate blood-brain-barrier permeability induced by acute stress. | The Journal of pharmacology and experimental therapeutics 20021201 |
| Antalarmin, a putative CRH-RI antagonist, has transient reinforcing effects in rhesus monkeys. | Psychopharmacology 20021101 |
| Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. | Brain research 20021018 |
| Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors. | Brain research 20021018 |
| Corticotropin-releasing hormone antagonists possess anti-inflammatory effects in the mouse ileum. | Gastroenterology 20020801 |
| Effect of antalarmin, a novel corticotropin-releasing hormone antagonist, on the dynamic function of the preterm ovine fetal hypothalamo-pituitary-adrenal axis. | Neuroendocrinology 20020701 |
| The highly selective CRF(2) receptor antagonist K41498 binds to presynaptic CRF(2) receptors in rat brain. | British journal of pharmacology 20020701 |
| Neuroendocrine aspects of the response to stress. | Metabolism: clinical and experimental 20020601 |
| Corticotropin releasing hormone (CRH) antagonist attenuates adjuvant induced arthritis: role of CRH in peripheral inflammation. | The Journal of rheumatology 20020601 |
| Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase. | The Journal of biological chemistry 20020405 |
| 4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine hydrochloride (SSR125543A), a potent and selective corticotrophin-releasing factor(1) receptor antagonist. II. Characterization in rodent models of stress-related disorders. | The Journal of pharmacology and experimental therapeutics 20020401 |
| On the role of corticotropin-releasing hormone receptors in anxiety and depression. | Dialogues in clinical neuroscience 20020301 |
| Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs. | Molecular psychiatry 20020101 |
| Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance. | Nature immunology 20011101 |
| Effects of SR48968, a selective non-peptide NK2 receptor antagonist on emotional processes in rodents. | Psychopharmacology 20011101 |
| A corticotropin-releasing hormone type I receptor antagonist delays parturition in sheep. | Endocrinology 19980701 |
| In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. | Endocrinology 19961201 |
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