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157115-85-0 | Glycine, 1-(2-phenylacetyl)-L-prolyl-, ethyl ester
CAS No: 157115-85-0 Catalog No: AG001P85 MDL No:MFCD00941121
Product Description
Catalog Number:
AG001P85
Chemical Name:
Glycine, 1-(2-phenylacetyl)-L-prolyl-, ethyl ester
CAS Number:
157115-85-0
Molecular Formula:
C17H22N2O4
Molecular Weight:
318.3676
MDL Number:
MFCD00941121
IUPAC Name:
ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate
InChI:
InChI=1S/C17H22N2O4/c1-2-23-16(21)12-18-17(22)14-9-6-10-19(14)15(20)11-13-7-4-3-5-8-13/h3-5,7-8,14H,2,6,9-12H2,1H3,(H,18,22)/t14-/m0/s1
InChI Key:
PJNSMUBMSNAEEN-AWEZNQCLSA-N
SMILES:
CCOC(=O)CNC(=O)[C@@H]1CCCN1C(=O)Cc1ccccc1
UNII:
4QBJ98683M
Properties
Complexity:
432
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
318.158g/mol
Formal Charge:
0
Heavy Atom Count:
23
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
318.373g/mol
Monoisotopic Mass:
318.158g/mol
Rotatable Bond Count:
7
Topological Polar Surface Area:
75.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.5
Literature
| Title | Journal |
|---|---|
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| [On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines]. | Eksperimental'naia i klinicheskaia farmakologiia 20101201 |
| Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 pyramidal cells. | Neuroscience letters 20100531 |
| [Effect of the novel nootropic and neuroprotective dipeptide noopept on the streptozotocin-induced model of sporadic Alzheimer disease in rats]. | Eksperimental'naia i klinicheskaia farmakologiia 20100101 |
| Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin. | Neuroscience and behavioral physiology 20090301 |
| Noopept reduces the postischemic functional and metabolic disorders in the brain of rats with different sensitivity to hypoxia. | Bulletin of experimental biology and medicine 20090301 |
| Genotype-dependent characteristics of behavior in mice in cognitive tests. The effects of Noopept. | Neuroscience and behavioral physiology 20090101 |
| [Prevention of neuro- and cardiotoxic side effects of tuberculosis chemotherapy with noopept]. | Klinicheskaia meditsina 20090101 |
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| [The original nootropic and neuroprotective drug noopept potentiates the anticonvulsant activity of valproate in mice]. | Eksperimental'naia i klinicheskaia farmakologiia 20090101 |
| Noopept stimulates the expression of NGF and BDNF in rat hippocampus. | Bulletin of experimental biology and medicine 20080901 |
| Original nootropic drug noopept prevents memory deficit in rats with muscarinic and nicotinic receptor blockade. | Bulletin of experimental biology and medicine 20080701 |
| Noopept efficiency in experimental Alzheimer disease (cognitive deficiency caused by beta-amyloid25-35 injection into Meynert basal nuclei of rats). | Bulletin of experimental biology and medicine 20080701 |
| [A comparative study of noopept and piracetam in the treatment of mild and moderate cognitive impairment in patients with organic brain diseases of vascular and traumatic origin]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101 |
| [Clinical and electroencephalographic characteristic of noopept in patients with mild cognitive impairment of posttraumatic and vascular origin]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101 |
| [The using of noopept in treatment of neurasthenia]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101 |
| The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model. | Journal of psychopharmacology (Oxford, England) 20070801 |
| Immunopharmacological properties of noopept. | Bulletin of experimental biology and medicine 20070701 |
| Dipeptide preparation Noopept prevents scopolamine-induced deficit of spatial memory in BALB/c mice. | Bulletin of experimental biology and medicine 20070401 |
| [Effects of noopept and cortexin on the behavior of matured rats treated with corticoliberin or 70-kDa heat shock proteins in early ontogeny]. | Eksperimental'naia i klinicheskaia farmakologiia 20070101 |
| [Behavior of mice from different strains: modifications produced by noopept]. | Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20070101 |
| [Genotype-dependent mice behavior in cognitive tasks. Effect of noopept]. | Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20070101 |
| Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis. | Bulletin of experimental biology and medicine 20060801 |
| [Neuroprotective activity of the proline-containing dipeptide noopept on the model of brain ischemia induced by the middle cerebral artery occlusion]. | Eksperimental'naia i klinicheskaia farmakologiia 20060101 |
| Early postnatal effects of noopept and piracetam on declarative and procedural memory of adult male and female rats. | Bulletin of experimental biology and medicine 20050601 |
| [Comparative study of the long-term behavioral effects of noopept and piracetam in adult male rats and female rats in postnatal period]. | Eksperimental'naia i klinicheskaia farmakologiia 20050101 |
| [Noopept improves the spatial memory and stimulates prefibrillar beta-amyloid(25-35) antibody production in mice]. | Eksperimental'naia i klinicheskaia farmakologiia 20050101 |
| Relationship between changes in rat behavior and integral biochemical indexes determined by laser correlation spectroscopy after photothrombosis of the prefrontal cortex. | Bulletin of experimental biology and medicine 20040201 |
| [Interspecies differences of noopept pharmacokinetics]. | Eksperimental'naia i klinicheskaia farmakologiia 20040101 |
| Effect of noopept and afobazole on the development of neurosis of learned helplessness in rats. | Bulletin of experimental biology and medicine 20030801 |
| Cyclopropyl glycine and proline-containing preparation noopept evoke two types of membrane potential responses in synaptoneurosomes. | Bulletin of experimental biology and medicine 20030601 |
| GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons. | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20030501 |
| [Regulation of the neuronal functional state by ultra low doses of different biologically active substances. Nonspecific effect ]. | Radiatsionnaia biologiia, radioecologiia 20030101 |
| [Evolution of the neuroprotection concept]. | Eksperimental'naia i klinicheskaia farmakologiia 20030101 |
| [Pharmacological regulation of emotional stress reactions]. | Vestnik Rossiiskoi akademii meditsinskikh nauk 20030101 |
| Impairment of learning and memory after photothrombosis of the prefrontal cortex in rat brain: effects of Noopept. | Bulletin of experimental biology and medicine 20021201 |
| Selective suppression of the slow-inactivating potassium currents by nootropics in molluscan neurons. | The international journal of neuropsychopharmacology 20020901 |
| [Preclinical study of noopept toxicity]. | Eksperimental'naia i klinicheskaia farmakologiia 20020101 |
| [Effect of the novel dipeptide nootropic agent noopept and its metabolite cyclo-L-prolylglycine on the transcallosal evoked potential in the rat brain]. | Eksperimental'naia i klinicheskaia farmakologiia 20020101 |
| [Multicomponent antithrombotic effect of the neuroprotective prolyl dipeptide GVS-111 and its major metabolite cyclo-L-prolylglycine]. | Eksperimental'naia i klinicheskaia farmakologiia 20020101 |
| [Anti-inflammatory properties of noopept (dipeptide nootropic agent GVS-111)]. | Eksperimental'naia i klinicheskaia farmakologiia 20020101 |
| [The original novel nootropic and neuroprotective agent noopept]. | Eksperimental'naia i klinicheskaia farmakologiia 20020101 |
| [The role of non-NMDA glutamate receptors in the EEG effects of chronic administration of noopept GVS-111 in awake rats]. | Eksperimental'naia i klinicheskaia farmakologiia 20020101 |
| Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration. | Bulletin of experimental biology and medicine 20011001 |
| [Behavioral and electrophysiological analysis of the choline-positive effect of nootropic dipeptide acylproline (GVS-111)]. | Eksperimental'naia i klinicheskaia farmakologiia 20010101 |
| [Effect of nootropic agents on impulse activity of cerebral cortex neurons]. | Eksperimental'naia i klinicheskaia farmakologiia 20010101 |
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