200,000+ products from a single source!
sales@angenechem.com
Home > Other Building Blocks > 15686-83-6
15686-83-6 | Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-[(1E)-2-(2-thienyl)ethenyl]-
CAS No: 15686-83-6 Catalog No: AG001P1I MDL No:MFCD00242767
Product Description
Catalog Number:
AG001P1I
Chemical Name:
Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-[(1E)-2-(2-thienyl)ethenyl]-
CAS Number:
15686-83-6
Molecular Formula:
C11H14N2S
Molecular Weight:
206.3073
MDL Number:
MFCD00242767
IUPAC Name:
1-methyl-2-[(E)-2-thiophen-2-ylethenyl]-5,6-dihydro-4H-pyrimidine
InChI:
InChI=1S/C11H14N2S/c1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h2,4-6,9H,3,7-8H2,1H3/b6-5+
InChI Key:
YSAUAVHXTIETRK-AATRIKPKSA-N
SMILES:
CN1CCCN=C1/C=C/c1cccs1
EC Number:
239-774-1
UNII:
4QIH0N49E7
Properties
Complexity:
248
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1
Exact Mass:
206.088g/mol
Formal Charge:
0
Heavy Atom Count:
14
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
206.307g/mol
Monoisotopic Mass:
206.088g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
43.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.6
Literature
| Title | Journal |
|---|---|
| Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance. | Veterinary parasitology 20150615 |
| Levamisole receptors: a second awakening. | Trends in parasitology 20120701 |
| Feline intestinal parasites in Finland: prevalence, risk factors and anthelmintic treatment practices. | Journal of feline medicine and surgery 20120601 |
| Determination of N-methyl-1,3-propanediamine in bovine muscle by liquid chromatography with triple quadrupole and ion trap tandem mass spectrometry detection. | Journal of chromatography. A 20120427 |
| Specificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiation. | Molecular pharmacology 20120201 |
| Impaired efficacy of ivermectin against Parascaris equorum, and both ivermectin and pyrantel against strongyle infections in trotter foals in Finland. | Veterinary parasitology 20111215 |
| Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans. | International journal for parasitology 20110301 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Efficacy, safety and palatability of a new broad-spectrum anthelmintic formulation in dogs. | The Veterinary record 20101023 |
| Resistance of gastrointestinal nematodes of sheep to some anthelmintics. | Journal of the Egyptian Society of Parasitology 20100801 |
| Discovery of a highly synergistic anthelmintic combination that shows mutual hypersusceptibility. | Proceedings of the National Academy of Sciences of the United States of America 20100330 |
| Efficacy of a combination product containing pyrantel, febantel and praziquantel (Drontal Plus Flavour, Bayer Animal Health) against experimental infection with the hookworm Ancylostoma ceylanicum in dogs. | Parasitology research 20100101 |
| [A survey on anthelmintic resistance in Strongyles to ivermectin and pyrantel and macrocyclic lactone-resistance in Parascaris equorum]. | Turkiye parazitolojii dergisi 20100101 |
| Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors. | The Journal of biological chemistry 20090807 |
| Acetylcholine receptor subunit genes from Ancylostoma caninum: altered transcription patterns associated with pyrantel resistance. | International journal for parasitology 20090301 |
| Pyrantel in small animal medicine: 30 years on. | Veterinary journal (London, England : 1997) 20081101 |
| Application of in vitro anthelmintic sensitivity assays to canine parasitology: detecting resistance to pyrantel in Ancylostoma caninum. | Veterinary parasitology 20080415 |
| Parascaris equorum in foals and in their environment on a Swedish stud farm, with notes on treatment failure of ivermectin. | Veterinary parasitology 20080214 |
| Ascaris lumbricoides: a travel joke? | Tennessee medicine : journal of the Tennessee Medical Association 20070901 |
| Activation of single nicotinic receptor channels from Caenorhabditis elegans muscle. | Molecular pharmacology 20070501 |
| Field evaluation of the efficacy and the safety of a combination of oxantel/pyrantel/praziquantel in the treatment of naturally acquired gastrointestinal nematode and/or cestode infestations in dogs in Europe. | Veterinary parasitology 20070410 |
| Cases of reduced cyathostomin egg-reappearance period and failure of Parascaris equorum egg count reduction following ivermectin treatment as well as survey on pyrantel efficacy on German horse farms. | Veterinary parasitology 20070315 |
| High-level pyrantel resistance in the hookworm Ancylostoma caninum. | Veterinary parasitology 20070227 |
| Survey of intestinal parasites in stray dogs in the Madrid area and comparison of the efficacy of three anthelmintics in naturally infected dogs. | Parasitology research 20070101 |
| Mode of action of levamisole and pyrantel, anthelmintic resistance, E153 and Q57. | Parasitology 20070101 |
| Parasite control practices on Swedish horse farms. | Acta veterinaria Scandinavica 20070101 |
| Molecular determinants of pyrantel selectivity in nicotinic receptors. | Molecular pharmacology 20061001 |
| Anthelmintic use and resistance on thoroughbred training yards in the UK. | The Veterinary record 20060429 |
| Efficacy of a combination of febantel, pyrantel, and praziquantel for the treatment of kittens experimentally infected with Giardia species. | Journal of feline medicine and surgery 20060201 |
| The effect of dimethoate and pyrantel on vitamin C concentration in the rat liver. | Polish journal of veterinary sciences 20060101 |
| Immuno-epidemiology of Ascaris lumbricoides infection in a high transmission community: antibody responses and their impact on current and future infection intensity. | Parasite immunology 20050301 |
| [The (children's) parasitic worms]. | Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20041201 |
| Efficacy of long-term monthly administration of ivermectin on the progress of naturally acquired heartworm infections in dogs. | Veterinary parasitology 20041005 |
| Mutation of the feh-1 gene, the Caenorhabditis elegans orthologue of mammalian Fe65, decreases the expression of two acetylcholinesterase genes. | The European journal of neuroscience 20040901 |
| Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. | International journal for parasitology 20040801 |
| Methyridine (2-[2-methoxyethyl]-pyridine]) and levamisole activate different ACh receptor subtypes in nematode parasites: a new lead for levamisole-resistance. | British journal of pharmacology 20031101 |
| Comparative efficacy of flubendazole chewable tablets and a tablet combination of febantel, pyrantel embonate and praziquantel against Trichuris vulpis in experimentally infected dogs. | DTW. Deutsche tierarztliche Wochenschrift 20031001 |
| Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. | European journal of clinical pharmacology 20030901 |
| Ascaris egg profiles in human faeces: biological and epidemiological implications. | Parasitology 20030901 |
| A light and electron microscopic study on the synergistic effect of pyrantel and the febantel metabolite febendazole on adult Toxocara canis in vitro. | Parasitology research 20030701 |
| The efficacy of two anthelmintics against ascarids and hookworms in naturally infected cats. | Parasitology research 20030701 |
| Synergistic effects of pyrantel and the febantel metabolite fenbendazole on adult Toxocara canis. | Parasitology research 20030701 |
| Index of suspicion. | Pediatrics in review 20030601 |
| Management of drug-resistant cyathostominosis on a breeding farm in central North Carolina. | Equine veterinary journal 20030501 |
| [Delayed diagnosis of ascaridiasis in a female patient with broncho-obstructive and dyspeptic syndromes and eosinophilia]. | Klinicheskaia meditsina 20030101 |
| Factors associated with development of ileal impaction in horses with surgical colic: 78 cases (1986-2000). | Equine veterinary journal 20020701 |
| Polyparasitism with Schistosoma mansoni, geohelminths, and intestinal protozoa in rural Côte d'Ivoire. | The Journal of parasitology 20020601 |
| Apparent resistance of Parascaris equorum to macrocylic lactones. | The Veterinary record 20020302 |
| Efficacy of a combination febantel-praziquantel-pyrantel product, with or without vaccination with a commercial Giardia vaccine, for treatment of dogs with naturally occurring giardiasis. | Journal of the American Veterinary Medical Association 20020201 |
| Prevalence of levamisole and benzimidazole resistance in oesophagostomum populations of pig-breeding farms in North Rhine-Westphalia, Germany. | Parasitology research 20020101 |
| Anthelmintic resistance in nematodes of horses. | Veterinary research 20020101 |
| Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections. | Transactions of the Royal Society of Tropical Medicine and Hygiene 20020101 |
| Effects of anthelmintics on the development of eggs of Angiostrongylus costaricensis in vitro. | Journal of helminthology 20011201 |
| The anthelmintic pyrantel acts as a low efficacious agonist and an open-channel blocker of mammalian acetylcholine receptors. | Neuropharmacology 20010801 |
| Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. | Drug metabolism and disposition: the biological fate of chemicals 20010101 |
| Aspects of the pharmacology of a new anthelmintic: pyrantel. | British journal of pharmacology 19700201 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.