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Home > Fluorides > 155229-76-8
155229-76-8 | 6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, (3S,5R,6E)-
CAS No: 155229-76-8 Catalog No: AG001NR5 MDL No:
Product Description
Catalog Number:
AG001NR5
Chemical Name:
6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, (3S,5R,6E)-
CAS Number:
155229-76-8
Molecular Formula:
C24H26FNO4
Molecular Weight:
411.4659
IUPAC Name:
(E,3S,5R)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
InChI:
InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m0/s1
InChI Key:
FJLGEFLZQAZZCD-JUFISIKESA-N
SMILES:
OC(=O)C[C@H](C[C@H](/C=C/c1c(c2ccc(cc2)F)c2c(n1C(C)C)cccc2)O)O
Properties
Complexity:
590
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
1
Exact Mass:
411.185g/mol
Formal Charge:
0
Heavy Atom Count:
30
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
411.473g/mol
Monoisotopic Mass:
411.185g/mol
Rotatable Bond Count:
8
Topological Polar Surface Area:
82.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.5
Literature
| Title | Journal |
|---|---|
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| Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes. | Toxicology in vitro : an international journal published in association with BIBRA 20140901 |
| Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms. | The FEBS journal 20140801 |
| Statins modulate transcriptional activity of heme-oxygenase-1 promoter in NIH 3T3 Cells. | Journal of cellular biochemistry 20121101 |
| Dried blood spot analysis of an iron chelator--deferasirox and its potential application to therapeutic drug monitoring. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20121015 |
| Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia. | Blood 20121011 |
| Statin-dependent activation of protein kinase Cδ in acute promyelocytic leukemia cells and induction of leukemic cell differentiation. | Leukemia & lymphoma 20120901 |
| Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression. | Oncology reports 20120901 |
| Transcriptome analysis and in vivo activity of fluvastatin versus zoledronic acid in a murine breast cancer metastasis model. | Molecular pharmacology 20120901 |
| An open-label randomized controlled study of pegylated interferon/ribavirin combination therapy for chronic hepatitis C with versus without fluvastatin. | Journal of viral hepatitis 20120901 |
| Low-dose fluvastatin reverses the hypoxic pulmonary adventitial fibroblast phenotype in experimental pulmonary hypertension. | American journal of respiratory cell and molecular biology 20120801 |
| Chronic cough as a complication of treatment with statins: a case report. | Therapeutic advances in respiratory disease 20120801 |
| Statin inhibits hypoxia-induced endothelin-1 via accelerated degradation of HIF-1α in vascular smooth muscle cells. | Cardiovascular research 20120715 |
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| The interactions of atorvastatin and fluvastatin with carbamazepine, phenytoin and valproate in the mouse maximal electroshock seizure model. | European journal of pharmacology 20120105 |
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| Selected statins produce rapid spinal motor neuron loss in vitro. | BMC musculoskeletal disorders 20120101 |
| The difference in pharmacokinetics and pharmacodynamics between extended-release fluvastatin and immediate-release fluvastatin in healthy Chinese subjects. | Journal of biomedicine & biotechnology 20120101 |
| Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies. | PloS one 20120101 |
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| Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. | Cancer biology & therapy 20111015 |
| Combination of fluvastatin and losartan relieves atherosclerosis and macrophage infiltration in atherosclerotic plaques in rabbits. | Acta pharmacologica Sinica 20111001 |
| Fluvastatin enhances sorafenib cytotoxicity in melanoma cells via modulation of AKT and JNK signaling pathways. | Anticancer research 20111001 |
| Fluvastatin downregulates VEGF-A expression in TNF-α-induced retinal vessel tortuosity. | Investigative ophthalmology & visual science 20110927 |
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| [Improved virologic response in chronic hepatitis C treated with peginterferon, ribavirin and add-on drug]. | Nihon rinsho. Japanese journal of clinical medicine 20110501 |
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| Subtherapeutic, low-dose fluvastatin improves functional and morphological arterial wall properties in apparently healthy, middle-aged males--a pilot study. | Atherosclerosis 20110401 |
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| Long-term treatment with low-dose metoprolol CR/XL is associated with increased plaque echogenicity: the Beta-blocker Cholesterol-lowering Asymptomatic Plaque Study (BCAPS). | Atherosclerosis 20110401 |
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| Pretreatment evaluation and its application on palm oil mill effluent for bio-hydrogen enhancement and methanogenic activity repression. | Pakistan journal of biological sciences : PJBS 20090815 |
| Fluvastatin prevents podocyte injury in a murine model of HIV-associated nephropathy. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090801 |
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| No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin. | British journal of clinical pharmacology 20090801 |
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| Effect of fluvastatin on progression of coronary atherosclerotic plaque evaluated by virtual histology intravascular ultrasound. | JACC. Cardiovascular interventions 20090701 |
| Can statins alter coronary plaque composition assessed by radiofrequency backscatter intravascular ultrasound? | JACC. Cardiovascular interventions 20090701 |
| Pharmacokinetic drug interaction between fexofenadine and fluvastatin mediated by organic anion-transporting polypeptides in rats. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090628 |
| Cholesterol biosynthesis modulation regulates dengue viral replication. | Virology 20090620 |
| In vitro activity of terbinafine associated to amphotericin B, fluvastatin, rifampicin, metronidazole and ibuprofen against Pythium insidiosum. | Veterinary microbiology 20090612 |
| Fluvastatin accelerates re-endothelialization impaired by local sirolimus treatment. | European journal of pharmacology 20090610 |
| Fluvastatin/fenofibrate vs. simvastatin/ezetimibe in patients with metabolic syndrome: different effects on LDL-profiles. | European journal of clinical investigation 20090601 |
| Bisoprolol and fluvastatin for the reduction of perioperative cardiac mortality and myocardial infarction in intermediate-risk patients undergoing noncardiovascular surgery: a randomized controlled trial (DECREASE-IV). | Annals of surgery 20090601 |
| Conversion to tacrolimus and atorvastatin in cyclosporine-treated heart transplant recipients with dyslipidemia refractory to fluvastatin. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090601 |
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| Fluvastatin improves osteoporosis in fructose-fed insulin resistant model rats through blockade of the classical mevalonate pathway and antioxidant action. | International journal of molecular medicine 20090501 |
| Efficacy and safety of Monascus purpureus Went rice in children and young adults with secondary hyperlipidemia: a preliminary report. | European journal of internal medicine 20090501 |
| Statins and fenofibrate affect skeletal muscle chloride conductance in rats by differently impairing ClC-1 channel regulation and expression. | British journal of pharmacology 20090401 |
| Effect of fluvastatin on cardiac outcomes in kidney transplant patients with systemic lupus erythematosus: a randomized placebo-controlled study. | Arthritis and rheumatism 20090401 |
| Lysophosphatidylcholine increases Na+/Ca2+ exchanger expression via RhoB-geranylgeranylation in H9c2 cells. | Journal of pharmacological sciences 20090401 |
| Statins and fibrate target ClC-1 - from side effects to CLC pharmacology. | British journal of pharmacology 20090401 |
| The protective effect of fluvastatin on hydroxyl radical generation by inhibiting low-density lipoprotein (LDL) oxidation in the rat myocardium. | Microvascular research 20090301 |
| Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 20090301 |
| Fluvastatin attenuates severe hemorrhagic shock-induced organ damage in rats. | Resuscitation 20090301 |
| Novel biodegradable polyester poly(propylene succinate): synthesis and application in the preparation of solid dispersions and nanoparticles of a water-soluble drug. | AAPS PharmSciTech 20090301 |
| Reduced P-selectin in hearts pretreated with fluvastatin: a novel benefit for patients undergoing open heart surgery. | The Thoracic and cardiovascular surgeon 20090301 |
| [Statin therapy and muscle disorders]. | Orvosi hetilap 20090208 |
| Statin use in chronic heart failure: waiting for the results of large prospective outcome trials. | International journal of cardiology 20090206 |
| Fluvastatin reduces pulmonary vein spontaneous activity through nitric oxide pathway. | Journal of cardiovascular electrophysiology 20090201 |
| Enantioselectivity in the pharmacokinetic interaction between fluvastatin and lercanidipine in healthy volunteers. | Journal of clinical pharmacology 20090201 |
| Should high creatine kinase discourage the initiation or continuance of statins for the treatment of hypercholesterolemia? | Metabolism: clinical and experimental 20090201 |
| Statin treatment reduces glomerular inflammation and podocyte damage in rat deoxycorticosterone-acetate-salt hypertension. | Journal of hypertension 20090201 |
| [Effects of fluvastatin on the activation of p38 mitogen-activated protein kinase in glomerular mesangial cells under high concentration of glucose]. | Yao xue xue bao = Acta pharmaceutica Sinica 20090201 |
| Cerebrovascular events in renal transplant recipients. | Transplantation 20090115 |
| Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice. | Cancer research 20090115 |
| Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level. | European journal of pharmacology 20090114 |
| Clopidogrel: review of bioanalytical methods, pharmacokinetics/pharmacodynamics, and update on recent trends in drug-drug interaction studies. | Biomedical chromatography : BMC 20090101 |
| Different galenic formulations of fluvastatin have equal lipid-lowering potential but differ in reducing lipemia-induced endothelial dysfunction. | Coronary artery disease 20090101 |
| Possible mechanisms underlying statin-induced skeletal muscle toxicity in L6 fibroblasts and in rats. | Journal of pharmacological sciences 20090101 |
| Omega 3 fatty acids induce a marked reduction of apolipoprotein B48 when added to fluvastatin in patients with type 2 diabetes and mixed hyperlipidemia: a preliminary report. | Cardiovascular diabetology 20090101 |
| The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis. | BMC cardiovascular disorders 20090101 |
| Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. | BMC cancer 20090101 |
| [The effect of statin treatment on inflammation in patients with metabolic syndrome]. | Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20090101 |
| Human cardiac fibroblasts express B-type natriuretic peptide: fluvastatin ameliorates its up-regulation by interleukin-1alpha, tumour necrosis factor-alpha and transforming growth factor-beta. | Journal of cellular and molecular medicine 20090101 |
| An open pilot study exploring the efficacy of fluvastatin, pegylated interferon and ribavirin in patients with hepatitis C virus genotype 1b in high viral loads. | Intervirology 20090101 |
| Improvement in chemical and physical stability of fluvastatin drug through hydrogen bonding interactions with different polymer matrices. | Current drug delivery 20090101 |
| Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis. | Modern rheumatology 20090101 |
| Effect of HMG-CoA reductase inhibitors on activation of human gammadeltaT cells induced by Mycobacterium tuberculosis antigens. | Immunopharmacology and immunotoxicology 20090101 |
| Metabolic syndrome and cardiovascular risk in renal transplant recipients: effects of statin treatment. | Clinical transplantation 20090101 |
| Fluvastatin increases tyrosinase synthesis induced by UVB irradiation of B16F10 melanoma cells. | Folia histochemica et cytobiologica 20090101 |
| Lovastatin and fluvastatin reduce viremia and the pro-inflammatory cytokines in the patients with chronic hepatitis C. | Hepato-gastroenterology 20090101 |
| Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model. | Drug metabolism and disposition: the biological fate of chemicals 20081201 |
| Intensive lipid-lowering therapy for patients with aortic stenosis. | The American journal of cardiology 20081201 |
| Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients. | Journal of the American College of Cardiology 20081125 |
| The influence of statin medications on prostate-specific antigen levels. | Journal of the National Cancer Institute 20081105 |
| Beneficial effects of fluvastatin on liver microcirculation and regeneration after massive hepatectomy in rats. | Digestive diseases and sciences 20081101 |
| Short-term effects of fluvastatin therapy on plasma interleukin-10 levels in patients with chronic heart failure. | Coronary artery disease 20081101 |
| Fluvastatin, rhabdomyolysis, and myotoxicity. | Mayo Clinic proceedings 20081101 |
| Stimulatory effects of low-dose 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor fluvastatin on hepatocyte growth factor-induced angiogenesis: involvement of p38 mitogen-activated protein kinase. | Hypertension research : official journal of the Japanese Society of Hypertension 20081101 |
| Effect of statins on fibroblasts from human nasal polyps and turbinates. | European annals of allergy and clinical immunology 20081101 |
| Toll-like receptor-4 is expressed in meningiomas and mediates the antiproliferative action of paclitaxel. | International journal of cancer 20081015 |
| DFT study on hydroxy acid-lactone interconversion of statins: the case of atorvastatin. | Organic & biomolecular chemistry 20081007 |
| HMG-CoA reductase inhibitors activate the unfolded protein response and induce cytoprotective GRP78 expression. | Cardiovascular research 20081001 |
| Comparison of lycopene and fluvastatin effects on atherosclerosis induced by a high-fat diet in rabbits. | Nutrition (Burbank, Los Angeles County, Calif.) 20081001 |
| Phase II study of metronomic chemotherapy with thalidomide, carboplatin-vincristine-fluvastatin in the treatment of brain stem tumors in children. | Archives of medical research 20081001 |
| Inhibitory effects of NO-fluvastatin on proliferation of human lens epithelial cells in vitro by modulating cell cycle regulatory proteins. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20081001 |
| Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication. | Liver international : official journal of the International Association for the Study of the Liver 20080901 |
| The human paraoxonase-1 phenotype modifies the effect of statins on paraoxonase activity and lipid parameters. | British journal of clinical pharmacology 20080901 |
| Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention. | International journal of cancer 20080901 |
| Effect of fluvastatin on serum prohepcidin levels in patients with end-stage renal disease. | Clinical biochemistry 20080901 |
| Comparative pharmacological study of free radical scavenger, nitric oxide synthase inhibitor, nitric oxide synthase activator and cyclooxygenase inhibitor against MPTP neurotoxicity in mice. | Metabolic brain disease 20080901 |
| Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy. | Pharmacogenomics 20080901 |
| [Impact of statins on clopidogrel platelet inhibition in patients with acute coronary syndrome or stable angina]. | Zhonghua xin xue guan bing za zhi 20080901 |
| Correlates of LDL-cholesterol goal attainment in patients under lipid lowering therapy. | Atherosclerosis 20080801 |
| Effect of APOE genotype on lipid levels in patients with coronary heart disease during a 3-week inpatient rehabilitation program. | Clinical pharmacology and therapeutics 20080801 |
| Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres. | British journal of pharmacology 20080801 |
| In-vitro synergism of m-TOR inhibitors, statins, and classical chemotherapy: potential implications in acute leukemia. | Anti-cancer drugs 20080801 |
| Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress. | Cancer investigation 20080801 |
| Chiral separation of fluvastatin enantiomers by capillary electrophoresis. | Archives of pharmacal research 20080801 |
| Fluvastatin in the prevention of renal transplant vasculopathy: results of a prospective, randomized, double-blind, placebo-controlled trial. | Transplantation 20080715 |
| Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/cyclin E expression. | Molecular pharmacology 20080701 |
| [Effects of fluvastatin on the expression of Janus kinase 2/signal transducers and activators of transcription (JAK/STAT) in glomerular mesangial cells under high concentration of glucose]. | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20080701 |
| Fluvastatin prevents glutamate-induced blood-brain-barrier disruption in vitro. | Life sciences 20080620 |
| Fluvastatin decreases cardiac fibrosis possibly through regulation of TGF-beta(1)/Smad 7 expression in the spontaneously hypertensive rats. | European journal of pharmacology 20080610 |
| Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2. | Arteriosclerosis, thrombosis, and vascular biology 20080601 |
| Efficacy and safety of Monascus purpureus Went rice in subjects with secondary hyperlipidemia. | Clinical and experimental nephrology 20080601 |
| Fluvastatin inhibits hepatitis C replication in humans. | The American journal of gastroenterology 20080601 |
| Topical application of statin affects bone healing around implants. | Clinical oral implants research 20080601 |
| The use of fluvastatin in cardiovascular risk management. | Expert opinion on pharmacotherapy 20080601 |
| HCV replication and statin pleotropism: an adjuvant treatment panacea? | The American journal of gastroenterology 20080601 |
| [Pleiotropic effects of statins]. | Revista medica de Chile 20080601 |
| Cardioprotective effect of fluvastatin on isoproterenol-induced myocardial infarction in rat. | European journal of pharmacology 20080531 |
| Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, fluvastatin, on coronary spasm after withdrawal of calcium-channel blockers. | Journal of the American College of Cardiology 20080506 |
| Statin and stromal cell-derived factor-1 additively promote angiogenesis by enhancement of progenitor cells incorporation into new vessels. | Stem cells (Dayton, Ohio) 20080501 |
| The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. | Pharmacogenetics and genomics 20080501 |
| Prevention of amyloid beta-induced memory impairment by fluvastatin, associated with the decrease in amyloid beta accumulation and oxidative stress in amyloid beta injection mouse model. | International journal of molecular medicine 20080501 |
| Fluvastatin improves arterial stiffness in patients with coronary artery disease and hyperlipidemia: a 5-year follow-up study. | Circulation journal : official journal of the Japanese Circulation Society 20080501 |
| Short term fluvastatin treatment lowers serum asymmetric dimethylarginine levels in patients with metabolic syndrome. | International heart journal 20080501 |
| Statin induced myotoxicity: the lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20080423 |
| Fluvastatin potentiates the activity of caspofungin against Aspergillus fumigatus in vitro. | Diagnostic microbiology and infectious disease 20080401 |
| Regulation of the PTEN promoter by statins and SREBP. | Human molecular genetics 20080401 |
| Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2. | Journal of thrombosis and haemostasis : JTH 20080401 |
| Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study. | Pharmacogenetics and genomics 20080401 |
| Lipid levels and low-density lipoprotein cholesterol goal attainment in diabetic patients: rosuvastatin compared with other statins in usual care. | Expert opinion on pharmacotherapy 20080401 |
| [Influence of statins on the antiplatelet effect of clopidogrel and on cardiovascular outcome in patients after coronary intervention]. | Deutsche medizinische Wochenschrift (1946) 20080401 |
| Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure. | International journal of cardiology 20080220 |
| Efficacy and tolerability of fluvastatin XL 80 mg alone, ezetimibe alone, and the combination of fluvastatin XL 80 mg with ezetimibe in patients with a history of muscle-related side effects with other statins. | The American journal of cardiology 20080215 |
| Determination of two HMG-CoA reductase inhibitors, pravastatin and pitavastatin, in plasma samples using liquid chromatography-tandem mass spectrometry for pharmaceutical study. | Biomedical chromatography : BMC 20080201 |
| Impact of systemic hypertension on the cardiovascular benefits of statin therapy--a meta-analysis. | The American journal of cardiology 20080201 |
| The effects of short term statin treatment on left ventricular function and inflammatory markers in patients with chronic heart failure. | International journal of cardiology 20080111 |
| [Fluvastatin induces apoptosis on human tongue carcinoma cell line HSC-3]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080101 |
| Molecular modeling of two CYP2C19 SNPs and its implications for personalized drug design. | Protein and peptide letters 20080101 |
| Effects of fluvastatin extended-release (80 mg) alone and in combination with ezetimibe (10 mg) on low-density lipoprotein cholesterol and inflammatory parameters in patients with primary hypercholesterolemia: a 12-week, multicenter, randomized, open-label, parallel-group study. | Clinical therapeutics 20080101 |
| Fluvastatin treatment and withdrawal: effects on endothelial function. | Angiology 20080101 |
| Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin. | Clinical pharmacokinetics 20080101 |
| Rab-small GTPases are involved in fluvastatin and pravastatin-induced vacuolation in rat skeletal myofibers. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20071201 |
| Immediate effect of fluvastatin on lipid levels in acute coronary syndrome. | Molecular and cellular biochemistry 20071201 |
| Delayed postischemic treatment with fluvastatin improved cognitive impairment after stroke in rats. | Stroke 20071201 |
| Fluvastatin inhibits activation of JAK and STAT proteins in diabetic rat glomeruli and mesangial cells under high glucose conditions. | Acta pharmacologica Sinica 20071201 |
| Transcriptional and post-transcriptional regulation of preproendothelin-1 by plaque-prone hemodynamics. | Atherosclerosis 20071001 |
| Fluvastatin inhibits hypoxic proliferation and p38 MAPK activity in pulmonary artery fibroblasts. | American journal of respiratory cell and molecular biology 20071001 |
| Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones. | Cardiovascular research 20071001 |
| Effect of fluvastatin on vascular endothelial growth factor in rats with osteoporosis in process of fracture healing. | Chinese journal of traumatology = Zhonghua chuang shang za zhi 20071001 |
| Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. | Journal of cardiovascular pharmacology 20071001 |
| Genetic analysis of fluvastatin response and dyslipidemia in renal transplant recipients. | Journal of lipid research 20070901 |
| Fluvastatin blunts the effect of a high-fat meal on plasma triglyceride and high-sensitivity C-reactive protein concentrations in patients at high risk for cardiovascular events. | Coronary artery disease 20070901 |
| Marked elevation of liver transaminases after high-dose fluvastatin unmasks chronic hepatitis C: safety and re-challenge. | Acta neurologica Taiwanica 20070901 |
| Low-density lipoprotein cholesterol (LDL-C) levels and LDL-C goal attainment among elderly patients treated with rosuvastatin compared with other statins in routine clinical practice. | The American journal of geriatric pharmacotherapy 20070901 |
| Risk reduction and tolerability of fluvastatin in patients with the metabolic syndrome: a pooled analysis of thirty clinical trials. | Clinical therapeutics 20070901 |
| Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. | Drug metabolism and disposition: the biological fate of chemicals 20070801 |
| Fluvastatin inhibits regulated secretion of endothelial cell von Willebrand factor in response to diverse secretagogues. | The Biochemical journal 20070801 |
| Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. | Cancer research 20070801 |
| Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials. | Journal of the American College of Cardiology 20070731 |
| The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats. | European journal of pharmacology 20070730 |
| Effect of statin withdrawal on frequency of cardiac events after vascular surgery. | The American journal of cardiology 20070715 |
| Fluvastatin enhancement of trastuzumab and classical cytotoxic agents in defined breast cancer cell lines in vitro. | Breast cancer research and treatment 20070701 |
| Fluvastatin ameliorates endotoxin induced multiple organ failure in conscious rats. | Resuscitation 20070701 |
| Simvastatin and fluvastatin reduce interleukin-6 and interleukin-8 lipopolysaccharide (LPS) stimulated production by isolated human monocytes from chronic kidney disease patients. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20070701 |
| Effect of fluvastatin and valsartan, alone and in combination, on postprandial vascular inflammation and fibrinolytic activity in patients with essential hypertension. | Journal of cardiovascular pharmacology 20070701 |
| Fluvastatin alters platelet aggregability in patients with hypercholesterolemia: possible improvement of intraplatelet redox imbalance via HMG-CoA reductase. | Arteriosclerosis, thrombosis, and vascular biology 20070601 |
| Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction. | Clinical immunology (Orlando, Fla.) 20070601 |
| Fluvastatin reverses endothelial dysfunction and increased vascular oxidative stress in rat adjuvant-induced arthritis. | Arthritis and rheumatism 20070601 |
| Time-of-intake (morning versus evening) of extended-release fluvastatin in hyperlipemic patients is without influence on the pharmacodynamics (mevalonic acid excretion) and pharmacokinetics. | International journal of clinical pharmacology and therapeutics 20070601 |
| Fluvastatin and atorvastatin affect calcium homeostasis of rat skeletal muscle fibers in vivo and in vitro by impairing the sarcoplasmic reticulum/mitochondria Ca2+-release system. | The Journal of pharmacology and experimental therapeutics 20070501 |
| HIV envelope protein gp120-triggered CD4+ T-cell adhesion to vascular endothelium is regulated via CD4 and CXCR4 receptors. | Biochimica et biophysica acta 20070501 |
| Autoimmune hepatitis after treatment with fluvastatin. | Liver international : official journal of the International Association for the Study of the Liver 20070501 |
| Effect of paraoxonase 1 polymorphisms on the response of lipids and lipoprotein-associated enzymes to treatment with fluvastatin. | Archives of medical research 20070501 |
| Effect of clopidogrel on the steady-state pharmacokinetics of fluvastatin. | Journal of clinical pharmacology 20070501 |
| Suppressive effects of statins on acute promyelocytic leukemia cells. | Cancer research 20070501 |
| Effect of HMGCoA reductase inhibitors on cytochrome P450 expression in endothelial cell line. | Journal of cardiovascular pharmacology 20070501 |
| Efficacy and safety of extended-release fluvastatin in Turkish patients with hypercholesterolaemia: TULIPS (Turkish Lipid Study). | Current medical research and opinion 20070501 |
| The effect of fluvastatin on cardiac outcomes in patients with moderate to severe renal insufficiency: a pooled analysis of double-blind, randomized trials. | International journal of cardiology 20070412 |
| 3D structure modeling of cytochrome P450 2C19 and its implication for personalized drug design. | Biochemical and biophysical research communications 20070406 |
| Statins inhibit NK cell cytotoxicity by membrane raft depletion rather than inhibition of isoprenylation. | Atherosclerosis 20070401 |
| Tolerability of statins is not linked to CYP450 polymorphisms, but reduced CYP2D6 metabolism improves cholesteraemic response to simvastatin and fluvastatin. | Pharmacological research 20070401 |
| Inhibitors of the mevalonate pathway as potential therapeutic agents in multiple myeloma. | Leukemia research 20070301 |
| Pravastatin inhibits arrhythmias induced by coronary artery ischemia in anesthetized rats. | Journal of pharmacological sciences 20070301 |
| Fluvastatin as co-medication in heart transplant recipients with elevated creatine-kinase. | Transplantation proceedings 20070301 |
| Dose-dependent effects of docosahexaenoic acid supplementation on blood lipids in statin-treated hyperlipidaemic subjects. | Lipids 20070301 |
| Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells. | European journal of pharmacology 20070205 |
| Fluvastatin reduced liver injury in rat model of extrahepatic cholestasis. | Pediatric surgery international 20070201 |
| Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis. | International immunology 20070201 |
| [Effect of fluvastatin extended release on the protein-lipid structure of erythrocyte membrane and C-reactive protein in patients with hyperlipidemia]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20070201 |
| Fluvastatin and cancer. | International journal of clinical practice 20070101 |
| Effects of statins on restenosis after coronary stent implantation. | Angiology 20070101 |
| HMG-CoA reductase inhibitors reduce nicotine-induced expression of cellular adhesion molecules in cultured human coronary endothelial cells. | Journal of vascular research 20070101 |
| Involvement of the Rho/Rho kinase signaling pathway in platelet-derived growth factor BB-induced vascular endothelial growth factor expression in diabetic rat retina. | Japanese journal of ophthalmology 20070101 |
| [Influence of valsartan, fluvastatin extended release and their combination on arterial pressure, parameters of lipid metabolism, and endothelial function in patients with hypertensive disease]. | Kardiologiia 20070101 |
| Novel 'plum pudding' gels as potential drug-eluting stent coatings: controlled release of fluvastatin. | Journal of biomedical materials research. Part A 20061215 |
| DFT study on hydroxy acid-lactone interconversion of statins: The case of fluvastatin. | Organic & biomolecular chemistry 20061207 |
| Synthesis and characterization of a fluvastatin-releasing hydrogel delivery system to modulate hMSC differentiation and function for bone regeneration. | Biomaterials 20061201 |
| Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: reversal effect of fluvastatin therapy. | The Journal of pharmacology and experimental therapeutics 20061201 |
| Pharmacokinetic interaction between fluvastatin and diltiazem in rats. | Biopharmaceutics & drug disposition 20061201 |
| Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study. | British journal of pharmacology 20061201 |
| Early administration of fluvastatin, but not at the onset of ischemia or reperfusion, attenuates myocardial ischemia-reperfusion injury through the nitric oxide pathway rather than its antioxidant property. | Circulation journal : official journal of the Japanese Circulation Society 20061201 |
| The effect of fluvastatin on cICAM-1 as a biomarker of endothelial dysfunction in patients with dyslipidemia. | International angiology : a journal of the International Union of Angiology 20061201 |
| Efficacy and safety of fluvastatin in children and adolescents with heterozygous familial hypercholesterolaemia. | Acta paediatrica (Oslo, Norway : 1992) 20061101 |
| Toxicity of statins on rat skeletal muscle mitochondria. | Cellular and molecular life sciences : CMLS 20061001 |
| SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin. | Clinical pharmacology and therapeutics 20061001 |
| Neutrophil superoxide anion generation during atorvastatin and fluvastatin therapy used in coronary heart disease primary prevention. | Journal of cardiovascular pharmacology 20061001 |
| Antioxidants suppress plasma levels of lectinlike oxidized low-density lipoprotein receptor-ligands and reduce atherosclerosis in watanabe heritable hyperlipidemic rabbits. | Journal of cardiovascular pharmacology 20061001 |
| Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer. | World journal of gastroenterology 20060921 |
| Fluvastatin stabilizes the blood-brain barrier in vitro by nitric oxide-dependent dephosphorylation of myosin light chains. | Neuropharmacology 20060901 |
| Fluvastatin treatment is not associated with an increased incidence of cancer. | International journal of clinical practice 20060901 |
| Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells. | Molecular cancer therapeutics 20060901 |
| HMG-CoA reductase inhibitor fluvastatin prevents angiotensin II-induced cardiac hypertrophy via Rho kinase and inhibition of cyclin D1. | Life sciences 20060829 |
| Renal transplant dysfunction--importance quantified in comparison with traditional risk factors for cardiovascular disease and mortality. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060801 |
| The cost-effectiveness of fluvastatin in Hungary following successful percutaneous coronary intervention. | Cardiovascular drugs and therapy 20060801 |
| Effects of statins on experimental colitis in normocholesterolemic rats. | Scandinavian journal of gastroenterology 20060801 |
| Fluvastatin alters psychomotor performance and daily activity but not the spatial memory in rats. | The Tohoku journal of experimental medicine 20060801 |
| Ezetimibe effectively decreases LDL-cholesterol in HIV-infected patients. | AIDS (London, England) 20060801 |
| Chronic fluvastatin treatment alters vascular contraction by inhibiting the Rho/Rho-kinase pathway. | Clinical and experimental pharmacology & physiology 20060801 |
| Statins, especially atorvastatin, may improve survival following brachytherapy for clinically localized prostate cancer. | Urologic nursing 20060801 |
| Healing unhealthy Hungarian hearts--at what cost?--With what benefit? | Cardiovascular drugs and therapy 20060801 |
| Inhibitory effects of statins on human monocarboxylate transporter 4. | International journal of pharmaceutics 20060706 |
| Statins are associated with a reduced infrarenal abdominal aortic aneurysm growth. | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20060701 |
| Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho. | International journal of oncology 20060701 |
| Different anti-HCV profiles of statins and their potential for combination therapy with interferon. | Hepatology (Baltimore, Md.) 20060701 |
| Management of cardiovascular risk in patients receiving calcineurin inhibitors--a case report. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060701 |
| Persistence and adherence to cholesterol lowering agents: evidence from Régie de l'Assurance Maladie du Québec data. | American heart journal 20060701 |
| Column-switching high-performance liquid chromatographic analysis of fluvastatin in rat plasma by direct injection. | Journal of pharmaceutical and biomedical analysis 20060616 |
| Protective effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on copper-induced hydroxyl radical generation in the rat heart. | Toxicology 20060615 |
| The effect of different doses of fluvastatin on inflammatory markers in the early phase of acute coronary syndrome. | Clinica chimica acta; international journal of clinical chemistry 20060601 |
| Effect of low-density lipoprotein cholesterol on angiotensin II sensitivity: a randomized trial with fluvastatin. | Hypertension (Dallas, Tex. : 1979) 20060601 |
| TGF-beta1-induced thrombospondin-1 expression through the p38 MAPK pathway is abolished by fluvastatin in human coronary artery smooth muscle cells. | Vascular pharmacology 20060601 |
| Use of an indirect effect model to describe the LDL cholesterol-lowering effect by statins in hypercholesterolaemic patients. | Fundamental & clinical pharmacology 20060601 |
| Effects of fluvastatin and cigarette smoking on CYP2C9 activity measured using the probe S-warfarin. | European journal of clinical pharmacology 20060601 |
| The clinical relevance of low-density-lipoproteins size modulation by statins. | Cardiovascular drugs and therapy 20060601 |
| Management of dyslipidemia in renal disease and transplantation. | Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 20060601 |
| Effect of fluvastatin on apolipoprotein-defined lipoprotein subclasses in patients with chronic renal insufficiency. | Kidney international 20060501 |
| The effect of fluvastatin on plasma adiponectin levels in dyslipidaemia. | Clinical endocrinology 20060501 |
| Effect of lipid levels and lipid-lowering therapy on restenosis after coronary artery stenting. | The American journal of the medical sciences 20060501 |
| Is atorvastatin superior to other statins? Analysis of the clinical trials with atorvastatin having cardiovascular endpoints. | Reviews on recent clinical trials 20060501 |
| Hydroxymethylglutaryl-coenzyme A reductase inhibitors induce apoptosis in human cardiac myocytes in vitro. | Biochemical pharmacology 20060428 |
| Fluvastatin increases heterotopically induced ossicles in mice. | Clinical and experimental pharmacology & physiology 20060401 |
| Evaluation of the pharmacokinetic interaction between fluvastatin XL and cyclosporine in renal transplant recipients. | International journal of clinical pharmacology and therapeutics 20060401 |
| Inhibitory effects of fluvastatin on cytokine and chemokine production by peripheral blood mononuclear cells in patients with allergic asthma. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060401 |
| Chiral evaluation of fluvastatin in human plasma by high-performance liquid chromatography electrospray mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060307 |
| The association of common SNPs and haplotypes in the CETP and MDR1 genes with lipids response to fluvastatin in familial hypercholesterolemia. | Atherosclerosis 20060301 |
| Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling. | Journal of the American Society of Nephrology : JASN 20060301 |
| Hydroxymethylglutaryl-CoA reductase inhibitors in older persons with acute myocardial infarction: evidence for an age-statin interaction. | Journal of the American Geriatrics Society 20060301 |
| The insulin-like growth factor receptor 1 is a promising target for novel treatment approaches in neuroendocrine gastrointestinal tumours. | Endocrine-related cancer 20060301 |
| Use of hydroxy-methyl-glutaryl coenzyme A reductase inhibitors is associated with risk of lymphoid malignancies. | Cancer science 20060201 |
| Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. | Arthritis and rheumatism 20060201 |
| [Statins in patients with kidney failure: efficacy, tolerance, and prescription guidelines in patients with chronic kidney disease and renal transplant]. | Presse medicale (Paris, France : 1983) 20060201 |
| C-reactive protein-induced upregulation of extracellular matrix metalloproteinase inducer in macrophages: inhibitory effect of fluvastatin. | Life sciences 20060125 |
| Folate co-administration improves the effectiveness of fenofibrate to decrease the lipoprotein oxidation and endothelial dysfunction surrogates. | Physiological research 20060101 |
| Statins and osteoporosis: new role for old drugs. | The Journal of pharmacy and pharmacology 20060101 |
| Inhibitory effects of amlodipine and fluvastatin on the deposition of advanced glycation end products in aortic wall of cholesterol and fructose-fed rabbits. | Biological & pharmaceutical bulletin 20060101 |
| Ezetimibe for the treatment of uncontrolled hypercholesterolemia in patients with high-dose statin therapy after renal transplantation. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060101 |
| Fluvastatin does not elevate periosteal osteogenesis induce by Moloney sarcoma virus (MSV) in mice. | Pharmacological reports : PR 20060101 |
| Liquid chromatography/negative ion electrospray tandem mass spectrometry method for the quantification of fluvastatin in human plasma: validation and its application to pharmacokinetic studies. | Rapid communications in mass spectrometry : RCM 20060101 |
| A disconnect between antitumor and antiangiogenic effects of fluvastatin in vitro and in vivo. | Neoplasma 20060101 |
| Zoledronic acid (Zometa) enhances the cytotoxic effect of gemcitabine and fluvastatin: in vitro isobologram studies with conventional and nonconventional cytotoxic agents. | Oncology 20060101 |
| Efficacy and safety of fluvastatin-extended release in hypercholesterolemic patients: morning administration is equivalent to evening administration. | Cardiology 20060101 |
| Cost-effectiveness analysis of cholesterol-lowering therapies in Spain. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101 |
| Influence of fluvastatin on bone formation induced by demineralized bone matrix in mice. | Pharmacological reports : PR 20060101 |
| Fluvastatin prevents oxidized low-density lipoprotein-induced injury of renal tubular epithelial cells by inhibiting the phosphatidylinositol 3-kinase/Akt-signaling pathway. | Journal of nephrology 20060101 |
| The renal safety profile of fluvastatin: results of a pooled analysis. | Renal failure 20060101 |
| No detrimental effect on renal function during long-term use of fluvastatin in renal transplant recipients in the Assessment of Lescol in Renal Transplantation (ALERT) study. | Clinical transplantation 20060101 |
| Fluvastatin and hepatic reactions: a signal from spontaneous reporting in Italy. | Drug safety 20060101 |
| Preventive effect of fluvastatin on ulcerative colitis-associated carcinogenesis in mice. | Anticancer research 20060101 |
| The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome. | The Journal of membrane biology 20060101 |
| Effects of fluvastatin on the carotid arterial media as assessed by integrated backscatter ultrasound compared with pulse-wave velocity. | Journal of the American College of Cardiology 20051206 |
| Long-term cardiac outcomes in renal transplant recipients receiving fluvastatin: the ALERT extension study. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20051201 |
| [Fluvastatin-induced dermatomyositis]. | Annales de dermatologie et de venereologie 20051201 |
| Does time of onset of therapy alter the protective cardiovascular effect of fluvastatin after renal transplantation? | Nature clinical practice. Nephrology 20051201 |
| EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer. | Biochemical pharmacology 20051125 |
| Focal seizures after treatment with fluvastatin in a patient with a history of catastrophic antiphospholipid syndrome. | Journal of the neurological sciences 20051115 |
| The effect of six different statins on the proliferation, migration, and invasion of human smooth muscle cells. | The Journal of surgical research 20051101 |
| Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension. | Arteriosclerosis, thrombosis, and vascular biology 20051101 |
| Statin-induced apoptosis linked with membrane farnesylated Ras small G protein depletion, rather than geranylated Rho protein. | The Journal of pharmacy and pharmacology 20051101 |
| Differential associations of statin and fibrate treatment with carotid arterial remodeling. | American journal of hypertension 20051101 |
| Statin toxicity: a situation that mimics viral hepatitis. | International journal of clinical pharmacology and therapeutics 20051101 |
| In-hospital initiation of statin therapy in acute coronary syndromes: maximizing the early and long-term benefits. | Chest 20051101 |
| Comparison of efficacy and safety assessment of fluvastatin in patients <65 years versus > or =65 years of age. | The American journal of cardiology 20051015 |
| Persistence and determinants of statin therapy among middle-aged patients free of cardiovascular disease. | European journal of clinical pharmacology 20051001 |
| [Early intervention on atherosclerosis by fluvastatin and lectin-like oxidized low-density lipoprotein receptor-1 expression in atherosclerotic arteries in immature rabbits]. | Zhonghua er ke za zhi = Chinese journal of pediatrics 20051001 |
| The long-term course of low-density lipoprotein cholesterol after initiation of statin treatment: retrospective database analysis over 3 years in health maintenance organization enrollees. | Clinical therapeutics 20051001 |
| [Fluvastatin affects HLA class I expression on endothelial cells]. | Nephrologie & therapeutique 20051001 |
| Evaluation of apoptosis and necrosis induced by statins using fluorescence-enhanced flow cytometry. | Journal of pharmaceutical and biomedical analysis 20050915 |
| Binding thermodynamics of statins to HMG-CoA reductase. | Biochemistry 20050906 |
| Combined therapy with atorvastatin and calcineurin inhibitors: no interactions with tacrolimus. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050901 |
| Long-term effects of antilipidaemic therapy on left ventricular function in patients with dyslipidaemia: multigated radionuclide ventriculography study. | Nuclear medicine communications 20050901 |
| Does fluvastatin really have an antioxidant effect in humans? | Kidney international 20050901 |
| Monocyte release of tumor necrosis factor-alpha and interleukin-1beta in primary type IIa and IIb dyslipidemic patients treated with statins or fibrates. | Journal of cardiovascular pharmacology 20050901 |
| Angiotensin II-induced oxidative burst is fluvastatin sensitive in neutrophils of patients with hypercholesterolemia. | Metabolism: clinical and experimental 20050901 |
| Cardiovascular risk and renal transplantation: post hoc analyses of the Assessment of Lescol in Renal Transplantation (ALERT) Study. | American journal of kidney diseases : the official journal of the National Kidney Foundation 20050901 |
| Fluvastatin: efficacy and safety in reducing cardiac events. | Expert opinion on pharmacotherapy 20050901 |
| Differences between statins on clinical endpoints: a population-based cohort study. | Current medical research and opinion 20050901 |
| [Influence of fluvastatin on left ventricular remodeling after myocardial infarction in rats]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20050901 |
| Regulation of connexin expression after balloon injury: possible mechanisms for antiproliferative effect of statins. | American journal of hypertension 20050901 |
| Effects of fluvastatin, an HMG-CoA reductase inhibitor, on serum levels of interleukin-18 and matrix metalloproteinase-9 in patients with hypercholesterolemia. | Clinical cardiology 20050901 |
| Decreased heart rate recovery in patients with heart failure: effect of fluvastatin therapy. | International heart journal 20050901 |
| A cost-effectiveness analysis of fluvastatin in patients with diabetes after successful percutaneous coronary intervention. | Clinical therapeutics 20050901 |
| Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells. | British journal of cancer 20050808 |
| Down-regulation of Na+/Ca2+ exchanger by fluvastatin in rat cardiomyoblast H9c2 cells: involvement of RhoB in Na+/Ca2+ exchanger mRNA stability. | Molecular pharmacology 20050801 |
| Effect of atorvastatin and fluvastatin on the metabolism of midazolam by cytochrome P450 in vitro. | Anaesthesia 20050801 |
| The effect of fluvastatin on the pharmacokinetics and pharmacodynamics of ezetimibe. | Current medical research and opinion 20050801 |
| Not all statins interfere with clopidogrel during antiplatelet therapy. | European journal of clinical investigation 20050801 |
| Efficacy and safety of slow-release fluvastatin 80 mg daily in Chinese patients with hypercholesterolemia. | Journal of the Chinese Medical Association : JCMA 20050801 |
| Polymorphonuclear leukocytes may impair endothelial function: results of crossover randomized study of lipid-lowering therapies. | Arteriosclerosis, thrombosis, and vascular biology 20050601 |
| Clinical practice guidelines for managing dyslipidemias in kidney transplant patients: lessons to be learnt from the assessment of Lescol in renal transplantation (ALERT) trial. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050601 |
| Clinical practice guidelines for managing dyslipidemias in kidney transplant patients. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050601 |
| Increased connexin43 expression in human saphenous veins in culture is associated with intimal hyperplasia. | Journal of vascular surgery 20050601 |
| Prediction of genotoxicity of chemical compounds by statistical learning methods. | Chemical research in toxicology 20050601 |
| Induction of micronuclei in CHO cells by bleomycin but not by X-irradiation is decreased by treatment with HMG-CoA reductase inhibitors. | Journal of radiation research 20050601 |
| Effect of fluvastatin on apoptosis in human CD4+ T cells. | Cellular immunology 20050601 |
| A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis. | Journal of the American College of Cardiology 20050517 |
| Renal dysfunction as a risk factor for mortality and cardiovascular disease in renal transplantation: experience from the Assessment of Lescol in Renal Transplantation trial. | Transplantation 20050515 |
| Different anticancer effects of fluvastatin on primary hepatocellular tumors and metastases in rats. | Cancer letters 20050510 |
| Beneficial effect of early initiation of lipid-lowering therapy following renal transplantation. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050501 |
| Nitric oxide mediates the effect of fluvastatin on intercellular adhesion molecule-1 and platelet endothelial cell adhesion molecule-1 expression on human endothelial cells. | Annals of vascular surgery 20050501 |
| Fluvastatin plus fish oil are more effective on cardiovascular risk factors than fluvastatin alone. | Prostaglandins, leukotrienes, and essential fatty acids 20050501 |
| Increase in the transcriptional activity of the endothelial nitric oxide synthase gene with fluvastatin: a relation with the -786T>C polymorphism. | Pharmacogenetics and genomics 20050501 |
| More on: fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells. | Journal of thrombosis and haemostasis : JTH 20050501 |
| A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: the ezetimibe add-on to statin for effectiveness (EASE) trial. | Mayo Clinic proceedings 20050501 |
| Immediate effects of fluvastain on circulating soluble endothelial protein C and free tissue factor pathway inhibitor in acute coronary syndromes. | Cardiovascular drugs and therapy 20050501 |
| Effectiveness of statins for secondary prevention in elderly patients after acute myocardial infarction: an evaluation of class effect. | CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20050426 |
| Fluvastatin prevents renal injury and expression of lactin-like oxidized low-density lipoprotein receptor-1 in rabbits with hypercholesterolemia. | Chinese medical journal 20050420 |
| Renoprotective effect of combining angiotensin II receptor blockers and statins in diabetic rats. | Chinese medical journal 20050405 |
| Endothelial dysfunction and hypercontractility of vascular myocytes are ameliorated by fluvastatin in obese Zucker rats. | American journal of physiology. Heart and circulatory physiology 20050401 |
| Cost-effectiveness of fluvastatin following successful first percutaneous coronary intervention. | The Annals of pharmacotherapy 20050401 |
| Fluvastatin ameliorates the hyperhomocysteinemia-induced endothelial dysfunction: the antioxidative properties of fluvastatin. | Circulation journal : official journal of the Japanese Circulation Society 20050401 |
| In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors. | Pharmaceutical research 20050401 |
| Anti-oxidative effect of fluvastatin in hyperlipidemic type 2 diabetic patients. | Endocrine journal 20050401 |
| [Effects of atorvastatin, fluvastatin, pravastatin, and simvastatin on endothelial function, lipid peroxidation, and aortic atherosclerosis in hypercholesterolemic rabbits]. | Arquivos brasileiros de cardiologia 20050401 |
| [Effects of fluvastatin on blood levels of inflammatory cytokines in patients with unstable angina undergoing percutaneous coronary intervention]. | Zhonghua xin xue guan bing za zhi 20050401 |
| Differential effect of LFA703, pravastatin, and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes. | Journal of leukocyte biology 20050301 |
| Fluvastatin inhibits the expression of tumor necrosis factor-alpha and activation of nuclear factor-kappaB in human endothelial cells stimulated by C-reactive protein. | Clinica chimica acta; international journal of clinical chemistry 20050301 |
| More on: Fluvastatin inhibits upregulation of tissue factor expression by antiphospholipid antibodies on endothelial cells. | Journal of thrombosis and haemostasis : JTH 20050301 |
| [The effect of early fluvastatin therapy on inflammatory factors in acute coronary syndrome]. | Zhonghua nei ke za zhi 20050301 |
| Fluvastatin reduces the 4-year cardiac risk in patients with multivessel disease. | International journal of cardiology 20050227 |
| Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug. | World journal of gastroenterology 20050221 |
| [Comparative study of effects of fluvastatin and losartan on left ventricular remodeling in rat myocardial infarction]. | Zhonghua yi xue za zhi 20050216 |
| Long-term fluvastatin reduces the hazardous effect of renal impairment on four-year atherosclerotic outcomes (a LIPS substudy). | The American journal of cardiology 20050215 |
| Long-term effects of statins on arterial pressure and stiffness of hypertensives. | Journal of human hypertension 20050201 |
| Fluvastatin prevents vascular hyperplasia by inhibiting phenotype modulation and proliferation through extracellular signal-regulated kinase 1 and 2 and p38 mitogen-activated protein kinase inactivation in organ-cultured artery. | Arteriosclerosis, thrombosis, and vascular biology 20050201 |
| A literature search on pharmacokinetic drug interactions of statins and analysis of how such interactions are reflected in package inserts in Japan. | Journal of clinical pharmacy and therapeutics 20050201 |
| Fluvastatin and lifestyle modification for reduction of carotid intima-media thickness and left ventricular mass progression in drug-treated hypertensives. | Atherosclerosis 20050201 |
| Fluvastatin increases the expression of adhesion molecules, monocyte chemoattractant protein-1 and tissue factor in HUVEC stimulated by patient IgG fractions containing antiphospholipid antibodies. | Thrombosis and haemostasis 20050201 |
| No effect of fluvastatin on the bone mineral density of children with minimal change glomerulonephritis and some focal mesangial cell proliferation, other than an ameliorating effect on their proteinuria. | Clinical nephrology 20050201 |
| A review of the lipid-related effects of fluvastatin. | Current medical research and opinion 20050201 |
| Revascularization of coronary atherosclerosis in patients with diabetes mellitus--there is more to it than meets the image intensifier. | American heart journal 20050201 |
| Fluvastatin reduces the impact of diabetes on long-term outcome after coronary intervention--a Lescol Intervention Prevention Study (LIPS) substudy. | American heart journal 20050201 |
| Risk factors for reaching renal endpoints in the assessment of Lescol in renal transplantation (ALERT) trial. | Transplantation 20050127 |
| Quantitative determination of fluvastatin in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry using [18O2]-fluvastatin as an internal standard. | Rapid communications in mass spectrometry : RCM 20050101 |
| A comparative crossover study of the effects of fluvastatin and pravastatin (FP-COS) on circulating autoantibodies to oxidized LDL in patients with hypercholesterolemia. | Journal of atherosclerosis and thrombosis 20050101 |
| Prevalence of potentially severe drug-drug interactions in ambulatory patients with dyslipidaemia receiving HMG-CoA reductase inhibitor therapy. | Drug safety 20050101 |
| [Pilot study of the noninvasive assessment of endothelial dysfunction by post-occlusion dopplerometry velocity curves analysis in arteria brachialis]. | Casopis lekaru ceskych 20050101 |
| Possible colchicine rhabdomyolysis in a fluvastatin-treated patient. | The Annals of pharmacotherapy 20050101 |
| Fluvastatin in the treatment of dyslipidemia associated with chronic kidney failure and renal transplantation. | Renal failure 20050101 |
| Sirolimus increases tissue factor expression but not activity in cultured human vascular smooth muscle cells. | BMC cardiovascular disorders 20050101 |
| Considerations in the treatment of dyslipidemia associated with chronic kidney failure and renal transplantation. | Preventive cardiology 20050101 |
| [Estimation of antioxidative effect of atorvastatin and fluvastatin used in primary prevention of coronary heart disease--effect on antioxidative enzymatic activity]. | Wiadomosci lekarskie (Warsaw, Poland : 1960) 20050101 |
| Enhancement of MMP-9 activity in THP-1 cells by 7-ketocholesterol and its suppression by the HMG-CoA reductase inhibitor fluvastatin. | Journal of atherosclerosis and thrombosis 20050101 |
| [Estimation of antioxidative effect of atorvastatin and fluvastatin used in primary prevention of coronary heart disease--effect on lipid peroxidation]. | Wiadomosci lekarskie (Warsaw, Poland : 1960) 20050101 |
| Effects of fluvastatin slow-release (XL 80 mg) versus simvastatin (20 mg) on the lipid triad in patients with type 2 diabetes. | Advances in therapy 20050101 |
| Effects of fluvastatin treatment on lipid profile, C-reactive protein trend, and renal function in dyslipidemic patients with chronic renal failure. | Advances in therapy 20050101 |
| Monitoring of peripheral blood cytotoxic T-cells under fluvastatin treatment in renal transplant recipients. | Journal of biological regulators and homeostatic agents 20050101 |
| Expression of serum and glucocorticoid-inducible kinase1 in diabetic rats and its modulation by fluvastatin. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101 |
| 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitor, fluvastatin, as a novel agent for prophylaxis of renal cancer metastasis. | Clinical cancer research : an official journal of the American Association for Cancer Research 20041215 |
| Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants. | Biochemistry 20041214 |
| HMG-CoA reductase inhibitor attenuates experimental autoimmune myocarditis through inhibition of T cell activation. | Cardiovascular research 20041201 |
| Relapse of respiratory insufficiency one year after organising pneumonia. | The European respiratory journal 20041201 |
| Fluvastatin reduces oxidative stress, decreases serum monocyte chemotactic protein-1 level and improves endothelial function in patients with hypercholesterolemia. | Journal of the Formosan Medical Association = Taiwan yi zhi 20041201 |
| Inhibitory effect of statins on the proliferation of human breast cancer cells. | International journal of clinical pharmacology and therapeutics 20041201 |
| Fluvastatin and bisoprolol for the reduction of perioperative cardiac mortality and morbidity in high-risk patients undergoing non-cardiac surgery: rationale and design of the DECREASE-IV study. | American heart journal 20041201 |
| Multiple antiplatelet effects of clopidogrel are not modulated by statin type in patients undergoing percutaneous coronary intervention. | Platelets 20041201 |
| Fluvastatin and lovastatin but not pravastatin induce neuroglial differentiation in human mesenchymal stem cells. | Journal of cellular biochemistry 20041115 |
| Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis. | Hypertension (Dallas, Tex. : 1979) 20041101 |
| Effects of statins on circulating oxidized low-density lipoprotein in patients with hypercholesterolemia. | Japanese heart journal 20041101 |
| Geranylgeraniol regulates negatively caspase-1 autoprocessing: implication in the Th1 response against Mycobacterium tuberculosis. | Journal of immunology (Baltimore, Md. : 1950) 20041015 |
| Beneficial effects of fluvastatin following percutaneous coronary intervention in patients with unstable and stable angina: results from the Lescol intervention prevention study (LIPS). | Heart (British Cardiac Society) 20041001 |
| Effect of fluvastatin on renal end points in the Assessment of Lescol in Renal Transplant (ALERT) trial. | Kidney international 20041001 |
| Immunosuppression in human peripheral blood T lymphocytes by fluvastatin. | Acta biochimica et biophysica Sinica 20041001 |
| Comparison of fluvastatin + fenofibrate combination therapy and fluvastatin monotherapy in the treatment of combined hyperlipidemia, type 2 diabetes mellitus, and coronary heart disease: a 12-month, randomized, double-blind, controlled trial. | Clinical therapeutics 20041001 |
| Is decreased libido associated with the use of HMG-CoA-reductase inhibitors? | British journal of clinical pharmacology 20040901 |
| Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells. | Journal of thrombosis and haemostasis : JTH 20040901 |
| Fluvastatin and fluvastatin extended release: a clinical and safety profile. | Expert review of cardiovascular therapy 20040901 |
| Impact of fluvastatin on hyperlipidemia after renal transplantation. | Transplantation proceedings 20040901 |
| Statin blocks Rho/Rho-kinase signalling and disrupts the actin cytoskeleton: relationship to enhancement of LPS-mediated nitric oxide synthesis in vascular smooth muscle cells. | Biochimica et biophysica acta 20040804 |
| Lipid lowering therapy with fluvastatin and pravastatin in patients with HIV infection and antiretroviral therapy: comparison of efficacy and interaction with indinavir. | Infection 20040801 |
| Statin decreases endothelial microparticle release from human coronary artery endothelial cells: implication for the Rho-kinase pathway. | Biochemical and biophysical research communications 20040716 |
| An evaluation of the in vitro metabolism data for predicting the clearance and drug-drug interaction potential of CYP2C9 substrates. | Drug metabolism and disposition: the biological fate of chemicals 20040701 |
| Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively. | The American journal of cardiology 20040701 |
| Safety and efficacy of fluvastatin in hyperlipidemic patients with chronic renal disease. | Renal failure 20040701 |
| Statins contribute to enhancement of the number and the function of endothelial progenitor cells from peripheral blood. | Sheng li xue bao : [Acta physiologica Sinica] 20040625 |
| [Not just decreased LDL level is decisive. Which statin for patients at risk for coronary disease?]. | MMW Fortschritte der Medizin 20040610 |
| [Despite coronary intervention, the risk remains high: PCI patients need additional protection]. | MMW Fortschritte der Medizin 20040610 |
| [Type 2 diabetic: risk same as after infarct. With LDL not only the quantity counts]. | MMW Fortschritte der Medizin 20040610 |
| fluvastatin prevents cardiac death and myocardial infarction in renal transplant recipients: post-hoc subgroup analyses of the ALERT Study. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040601 |
| Fluvastatin improves endothelial dysfunction in overweight postmenopausal women through small dense low-density lipoprotein reduction. | Metabolism: clinical and experimental 20040601 |
| Effect of fluvastatin therapy on coronary flow reserve in patients with hypercholesterolemia. | The American journal of cardiology 20040601 |
| Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis. | Hypertension (Dallas, Tex. : 1979) 20040601 |
| Update on statins. | Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing 20040601 |
| Effects of statins on oxidative stress. | Biological trace element research 20040501 |
| Class-specific pro-apoptotic effect of statins on human vascular endothelial cells. | Zeitschrift fur Kardiologie 20040501 |
| Cardiovascular drugs inhibit MMP-9 activity from human THP-1 macrophages. | DNA and cell biology 20040501 |
| [Statin-induced rhabdomyolysis and renal failure: also with fluvastatine]. | Anales de medicina interna (Madrid, Spain : 1984) 20040501 |
| The use of statins in optimising reduction of cardiovascular risk: focus on fluvastatin. | International journal of clinical practice 20040501 |
| Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages. | Biochemical and biophysical research communications 20040409 |
| ACE inhibitors and statins acutely improve endothelial dysfunction of human coronary arterioles. | American journal of physiology. Heart and circulatory physiology 20040401 |
| Efficacy and safety of fluvastatin therapy for hypercholesterolemia after heart transplantation: results of a randomised double blind placebo controlled study. | International journal of cardiology 20040401 |
| Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling. | Biochemical and biophysical research communications 20040312 |
| Steady-state pharmacokinetics of fluvastatin in healthy subjects following a new extended release fluvastatin tablet, Lescol XL. | Biopharmaceutics & drug disposition 20040301 |
| Fluvastatin slow-release lowers platelet-activating factor acetyl hydrolase activity: a placebo-controlled trial in patients with type 2 diabetes. | The Journal of clinical endocrinology and metabolism 20040301 |
| [Effects of angiotensin II receptor blockers, angiotensin converting enzyme inhibitors, 3-hydroxy-3-methyl glutaryl (HMG) CoA reductase inhibitors, amlodipine and epalrestat on cultured basilar artery smooth muscle cell proliferation]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040301 |
| Lipid-lowering effects of ethyl 2-phenacyl-3-aryl-1H-pyrrole- 4-carboxylates in rodents. | Molecules (Basel, Switzerland) 20040227 |
| Hydroxymethyl-glutaryl coenzyme a reductase inhibition limits cytomegalovirus infection in human endothelial cells. | Circulation 20040203 |
| Chronic treatment with fluvastatin improves smooth muscle dilatory function in genetically determined hyperlipoproteinemia. | Journal of cardiovascular pharmacology 20040201 |
| Fluvastatin treatment inhibits leucocyte adhesion and extravasation in models of complement-mediated acute inflammation. | Clinical and experimental immunology 20040201 |
| Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation. | Experimental and molecular pathology 20040201 |
| Plasma antioxidative activity during atorvastatin and fluvastatin therapy used in coronary heart disease primary prevention. | Fundamental & clinical pharmacology 20040201 |
| Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: a randomised pilot trial. | International journal of cardiology 20040201 |
| Oral anticoagulant drug interactions with statins: case report of fluvastatin and review of the literature. | Pharmacotherapy 20040201 |
| Fluvastatin inhibits raft dependent Fcgamma receptor signalling in human monocytes. | Atherosclerosis 20040201 |
| Peroxynitrite-mediated oxidative modification of low-density lipoprotein by aqueous extracts of cigarette smoke and the preventive effect of fluvastatin. | Atherosclerosis 20040201 |
| Antiproliferative effect of fluvastatin and thiazolidinedione in mesangial cells of diabetic rats. | Pediatric nephrology (Berlin, Germany) 20040101 |
| Effect of 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors (statins) on tissue paraoxonase 1 and plasma platelet activating factor acetylhydrolase activities. | Journal of cardiovascular pharmacology 20040101 |
| Comparisons of effects of statins (atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin) on fasting and postprandial lipoproteins in patients with coronary heart disease versus control subjects. | The American journal of cardiology 20040101 |
| Effect of fluvastatin on long-term outcome after coronary revascularization with stent implantation. | The American journal of cardiology 20040101 |
| Relationship between hypercholesterolemia, lipid-lowering therapy and coronary flow velocity reserve evaluated by stress transesophageal echocardiography in patients with a negative coronary angiogram. | Echocardiography (Mount Kisco, N.Y.) 20040101 |
| Pharmacokinetics and lipid-lowering effect of fluvastatin in hypercholesterolaemic patients on maintenance haemodialysis. | The Journal of international medical research 20040101 |
| Fluvastatin reduces cardiac mortality in patients with coronary heart disease. | Cardiovascular drugs and therapy 20040101 |
| The influence of statins on the free intracellular calcium concentration in human umbilical vein endothelial cells. | BMC cardiovascular disorders 20040101 |
| Effects of fluvastatin in type 2 diabetic patients with hyperlipidemia: reduction in cholesterol oxidation products and VCAM-1. | Journal of atherosclerosis and thrombosis 20040101 |
| Effects of fluvastatin on endothelium-derived hyperpolarizing factor- and nitric oxide-mediated relaxations in arteries of hypertensive rats. | Clinical and experimental pharmacology & physiology 20040101 |
| Fluvastatin: clinical and safety profile. | Drugs 20040101 |
| Lichenoid drug eruption with HMG-CoA reductase inhibitors (fluvastatin and lovastatin). | Acta dermato-venereologica 20040101 |
| An economic evaluation of fluvastatin used for the prevention of cardiac events following successful first percutaneous coronary intervention in the UK. | PharmacoEconomics 20040101 |
| Fluvastatin reduces renal fibroblast proliferation and production of type III collagen: therapeutic implications for tubulointerstitial fibrosis. | Nephron. Experimental nephrology 20040101 |
| Inhibitors of differentiation/DNA binding proteins Id1 and Id3 are regulated by statins in endothelial cells. | Endothelium : journal of endothelial cell research 20040101 |
| [Effects of long acting fluvastatin on parameters of lipid metabolism in patients with type 2 diabetes and combined hyperlipidemia]. | Kardiologiia 20040101 |
| Treatment with fluvastatin rapidly modulates, via different pathways, and in dependence on the baseline level, inflammation in hemodialysis patients. | Blood purification 20040101 |
| Effect of simvastatin and fluvastatin on plasma fibrinogen levels in patients with primary hypercholesterolemia. | Polish journal of pharmacology 20040101 |
| Regional intestinal absorption and biliary excretion of fluvastatin in the rat: possible involvement of mrp2. | Molecular pharmaceutics 20040101 |
| A propensity score-matched cohort study of the effect of statins, mainly fluvastatin, on the occurrence of acute myocardial infarction. | The American journal of cardiology 20031215 |
| Statins induce suppressor of cytokine signaling-3 in macrophages. | FEBS letters 20031204 |
| Edaravone, a radical scavenger, may enhance or produce antiproliferative effects of fluvastatin, amlodipine, ozagrel, GF109203X and Y27632 on cultured basilar artery smooth muscle cells. | Biological & pharmaceutical bulletin 20031201 |
| Time-dependent lipid response on fluvastatin therapy of patients with hypercholesterolemia sensitive to apoE phenotype. | Vascular pharmacology 20031201 |
| HMG-CoA reductase inhibitor, fluvastatin, has cholesterol-lowering independent 'direct' effects on atherosclerotic vessels in high cholesterol diet-fed rabbits. | Pharmacological research 20031101 |
| Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model. | Arthritis and rheumatism 20031101 |
| Effects of statins on adhesion molecule expression in endothelial cells. | Journal of thrombosis and haemostasis : JTH 20031101 |
| Fluvastatin improves insulin resistance in nondiabetic dyslipidemic patients. | Endocrine 20031101 |
| A multicenter, randomized, double-blind clinical trial comparing the low-density lipoprotein cholesterol-lowering ability of lovastatin 10, 20, and 40 mg/d with fluvastatin 20 and 40 mg/d. | Clinical therapeutics 20031101 |
| Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. | International journal of oncology 20031001 |
| Effects of baseline level of triglycerides on changes in lipid levels from combined fluvastatin + fibrate (bezafibrate, fenofibrate, or gemfibrozil). | The American journal of cardiology 20031001 |
| Fenofibrate-induced hyperhomocysteinemia may be prevented by folate co-administration. | European journal of clinical pharmacology 20030901 |
| Protective effect of fluvastatin, an HMG-CoA reductase inhibitor, on the formation of 8-oxo-2'-deoxyguanosine in the nuclear DNA of hamster pancreas after a single administration of N-nitrosobis(2-oxopropyl)amine. | Biological & pharmaceutical bulletin 20030901 |
| A retrospective analysis of the effect of noncompliance on time to first major adverse cardiac event in LIPS. | Clinical therapeutics 20030901 |
| [The expression of connective tissue growth factor in renal cortex of 5/6 nephrectomized rats and its modulation by fluvastatin]. | Zhonghua yi xue za zhi 20030825 |
| Fluvastatin reduces atherogenic lipids without any effect on native endothelial function early after kidney transplantation. | Clinical transplantation 20030801 |
| Influence of CYP2C9 polymorphisms on the pharmacokinetics and cholesterol-lowering activity of (-)-3S,5R-fluvastatin and (+)-3R,5S-fluvastatin in healthy volunteers. | Clinical pharmacology and therapeutics 20030801 |
| Effect of fluvastatin and dipyridamole on proteinuria and renal function in childhood IgA nephropathy with mild histological findings and moderate proteinuria. | Clinical nephrology 20030801 |
| Fluvastatin attenuates nitrate tolerance in patients with ischemic heart disease complicating hypercholesterolemia. | International journal of cardiology 20030801 |
| Reduction of myocardial infarct size by fluvastatin. | American journal of physiology. Heart and circulatory physiology 20030701 |
| Preservation of endothelial function by the HMG-CoA reductase inhibitor fluvastatin through its lipid-lowering independent antioxidant properties in atherosclerotic rabbits. | Pharmacology 20030701 |
| Preservation of endothelium-dependent and Nomega-nitro-L-arginine methyl ester- and indomethacin-resistant arterial relaxation in high-cholesterol-diet fed rabbits by treatment with fluvastatin, an HMG-CoA reductase inhibitor. | Journal of cardiovascular pharmacology 20030701 |
| Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells. | Prostaglandins & other lipid mediators 20030701 |
| Effect of fluvastatin on cardiac outcomes in renal transplant recipients: a multicentre, randomised, placebo-controlled trial. | Lancet (London, England) 20030614 |
| Cost effectiveness of statin therapy for the primary prevention of major coronary events in individuals with type 2 diabetes. | Diabetes care 20030601 |
| Reduction of arteriosclerotic nanoplaque formation and size by fluvastatin in a receptor-based biosensor model. | Cardiovascular research 20030601 |
| Antioxidative potential of fluvastatin via the inhibition of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity. | Biological & pharmaceutical bulletin 20030601 |
| Beneficial effects of fluvastatin on progressive renal allograft dysfunction. | Transplantation proceedings 20030601 |
| The Lescol Intervention Prevention Study (LIPS): start all patients on statins early after PCI. | Cleveland Clinic journal of medicine 20030601 |
| Serum lipid comparison in patients treated by statins or fibrates: existence of bad HDL-C responders to statins. | Acta cardiologica 20030601 |
| The effect of an HMG-CoA reductase inhibitor on arteriosclerotic nanoplaque formation and size in a biosensor model. | Biosensors & bioelectronics 20030501 |
| Effect of a 3-year therapy with the 3-hydroxy-3-methylglutaryl coenzyme a reductase-inhibitor fluvastatin on endothelial function and distensibility of large arteries in hypercholesterolemic renal transplant recipient. | American journal of kidney diseases : the official journal of the National Kidney Foundation 20030501 |
| Effect of dietary intervention and lipid-lowering treatment on brachial vasoreactivity in patients with ischemic heart disease and hypercholesterolemia. | American heart journal 20030501 |
| [Treatment of hypercholesterolemia in kidney transplant recipients]. | Deutsche medizinische Wochenschrift (1946) 20030417 |
| [Better prognosis for dialysis dependent type 2 diabetic patient. Statin delays arterial onset of arterial stiffness]. | MMW Fortschritte der Medizin 20030417 |
| Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins. | Molecular pharmacology 20030401 |
| Vascular smooth muscle cell activation by C-reactive protein. | Cardiovascular research 20030401 |
| Randomized, double-blind, placebo-controlled comparison of the action of orlistat, fluvastatin, or both an anthropometric measurements, blood pressure, and lipid profile in obese patients with hypercholesterolemia prescribed a standardized diet. | Clinical therapeutics 20030401 |
| [Effect of fluvastatin and fenofibrate on reactive oxygen species generation and lipid peroxidation in patients with dyslipidemia]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030401 |
| [Effect of fluvastatin and fenofibrate on the antioxidative barrier enzyme activity in patients with dyslipidemia]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030401 |
| The sorry saga of the statins in New Zealand--pharmacopolitics versus patient care. | The New Zealand medical journal 20030314 |
| Response from PHARMAC: difficult choices. | The New Zealand medical journal 20030314 |
| Treating dyslipidemia with statins: the risk-benefit profile. | American heart journal 20030301 |
| Statins inhibit high glucose-mediated neutrophil-endothelial cell adhesion through decreasing surface expression of endothelial adhesion molecules by stimulating production of endothelial nitric oxide. | Microvascular research 20030301 |
| Comparison of treatment with fluvastatin extended-release 80-mg tablets and immediate-release 40-mg capsules in patients with primary hypercholesterolemia. | Clinical therapeutics 20030301 |
| Cytochrome P450 epoxygenases and vascular tone: novel role for HMG-CoA reductase inhibitors in the regulation of CYP 2C expression. | Biochimica et biophysica acta 20030217 |
| Fluvastatin induces apoptosis of vascular endothelial cells: blockade by glucocorticoids. | Cardiovascular surgery (London, England) 20030201 |
| Sensitive assay for the determination of fluvastatin in plasma utilizing high-performance liquid chromatography with fluorescence detection. | Therapeutic drug monitoring 20030201 |
| Fluvastatin prevents renal dysfunction and vascular NO deficit in apolipoprotein E-deficient mice. | Arteriosclerosis, thrombosis, and vascular biology 20030201 |
| Panax notoginseng (Burk.) effects on fibrinogen and lipid plasma level in rats fed on a high-fat diet. | Phytotherapy research : PTR 20030201 |
| Comparison of the effect of two HMG CoA reductase inhibitors on LDL susceptibility to oxidation. | Arquivos brasileiros de cardiologia 20030201 |
| Frequency of creatine kinase elevation during treatment with fluvastatin in combination with fibrates (bezafibrate, fenofibrate, or gemfibrozil). | The American journal of cardiology 20030115 |
| Fluvastatin enhances the inhibitory effects of a selective angiotensin II type 1 receptor blocker, valsartan, on vascular neointimal formation. | Circulation 20030107 |
| Fluvastin therapy affects TAFI concentration in kidney transplant recipients. | Transplant international : official journal of the European Society for Organ Transplantation 20030101 |
| A model to assess the cost effectiveness of statins in achieving the UK National Service Framework target cholesterol levels. | PharmacoEconomics 20030101 |
| An economic analysis of the Atorvastatin Comparative Cholesterol Efficacy and Safety Study (ACCESS). | PharmacoEconomics 20030101 |
| Variable influence of statins on isoprostanes in hyperlipidemia. | Advances in experimental medicine and biology 20030101 |
| Short-term efficacy and safety of extended-release fluvastatin in a large cohort of elderly patients. | The American journal of geriatric cardiology 20030101 |
| [Combination therapy with fluvastatin and fenofibrate in ischemic heart disease patients with combined hyperlipidemia and type 2 diabetes]. | Kardiologiia 20030101 |
| [High therapeutic effect and safety of fluvastatin]. | Pharmazie in unserer Zeit 20030101 |
| HMG CoA reductase inhibitor fluvastatin arrests the development of implanted hepatocarcinoma in rats. | Anticancer research 20030101 |
| Effects of D-003, a mixture of long-chain aliphatic primary acids, fluvastatin and the combined therapy of D-003 plus fluvastatin on the lipid profile of normocholesterolemic rabbits. | International journal of tissue reactions 20030101 |
| Statins in hypercholesterolaemia: a dose-specific meta-analysis of lipid changes in randomised, double blind trials. | BMC family practice 20030101 |
| Fluvastatin increases LDL particle size and reduces oxidative stress in patients with hyperlipidemia. | Journal of atherosclerosis and thrombosis 20030101 |
| Fluvastatin induces apoptosis in rat neonatal cardiac myocytes: a possible mechanism of statin-attenuated cardiac hypertrophy. | Journal of cardiovascular pharmacology 20021201 |
| Fluvastatin-induced rhabdomyolysis. | The Annals of pharmacotherapy 20021201 |
| Effect of fluvastatin slow-release on low density lipoprotein (LDL) subfractions in patients with type 2 diabetes mellitus: baseline LDL profile determines specific mode of action. | The Journal of clinical endocrinology and metabolism 20021201 |
| Effect of fluvastatin on ischaemia following acute myocardial infarction: a randomized trial. | European heart journal 20021201 |
| [Effects of fluvastatin on the levels of C-reactive protein and lipids in patients with hyperlipidemia]. | Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20021201 |
| Time-dependent effect of statins on platelet function in hypercholesterolaemia. | European journal of clinical investigation 20021201 |
| Rapid spectrophotometric method for quantitative determination of simvastatin and fluvastatin in human serum and pharmaceutical formulations. | Die Pharmazie 20021201 |
| Toward a role for statins in immunomodulation. | Molecular interventions 20021201 |
| Regulation of interleukin-8 expression by HMG-CoA reductase inhibitors in human vascular smooth muscle cells. | Atherosclerosis 20021101 |
| Effects of SREBF-1a and SCAP polymorphisms on plasma levels of lipids, severity, progression and regression of coronary atherosclerosis and response to therapy with fluvastatin. | Journal of molecular medicine (Berlin, Germany) 20021101 |
| Fluvastatin. | Expert opinion on pharmacotherapy 20021101 |
| Stereospecific disposition of fluvastatin in streptozotocin-induced diabetic rats. | Canadian journal of physiology and pharmacology 20021101 |
| Comparing the effects of five different statins on the HDL subpopulation profiles of coronary heart disease patients. | Atherosclerosis 20021001 |
| Fluvastatin remodels resistance arteries in genetically hypertensive rats, even in the absence of any effect on blood pressure. | Clinical and experimental pharmacology & physiology 20021001 |
| Hypercholesterolaemia and treatment with statins do not alter L-arginine-induced changes of renal haemodynamics. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20021001 |
| Biosensing of arteriosclerotic nanoplaque formation and interaction with an HMG-CoA reductase inhibitor. | Acta physiologica Scandinavica 20021001 |
| Severe rhabdomyolysis after laparoscopic surgery for adenocarcinoma of the rectum in two patients treated with statins. | Anesthesiology 20021001 |
| Antioxidative effects of fluvastatin and its metabolites against DNA damage in streptozotocin-treated mice. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021001 |
| Efficacy and safety of fluvastatin in hyperlipidemic protease inhibitor-treated HIV-infected patients. | AIDS (London, England) 20020927 |
| Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced nonselective cation current in Guinea pig ventricular myocytes. | Molecular pharmacology 20020901 |
| [Antilipemic agents in combined therapy]. | Orvosi hetilap 20020825 |
| Inhibition of proliferation and signalling mechanisms in human lymphocytes by fluvastatin. | Clinical and experimental pharmacology & physiology 20020801 |
| Impact of treatment of dyslipidemia on renal function, fat deposits and scarring in patients with persistent nephrotic syndrome. | Nephron 20020801 |
| Fluvastatin prevents development of arterial stiffness in haemodialysis patients with type 2 diabetes mellitus. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020801 |
| The HMG Co-A reductase inhibitors ('statins') and myotoxic effects. | South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20020801 |
| Valsartan therapy has additive anti-oxidative effect to that of fluvastatin therapy against low-density lipoprotein oxidation: studies in hypercholesterolemic and hypertensive patients. | Journal of cardiovascular pharmacology 20020701 |
| Statin-induced apoptosis of vascular endothelial cells is blocked by dexamethasone. | The Journal of endocrinology 20020701 |
| Cyclosporin A pharmacokinetics in a patient with psoriasis and obesity, presenting with high levels of low-density [correction for destiny] lipoprotein. | European journal of clinical pharmacology 20020701 |
| [Clinical study of the month. The LIPS study: fluvastatin for prevention of cardiac events following percutaneous coronary angioplasty]. | Revue medicale de Liege 20020701 |
| Fluvastatin for prevention of cardiac events following successful first percutaneous coronary intervention: a randomized controlled trial. | JAMA 20020626 |
| Preventing cardiac events and restenosis after percutaneous coronary intervention. | JAMA 20020626 |
| Statin enhances cytokine-mediated induction of nitric oxide synthesis in vascular smooth muscle cells. | Cardiovascular research 20020601 |
| Statins and risk of polyneuropathy: a case-control study. | Neurology 20020514 |
| [Effects of fluvastatin on plasma lipid abnormalities in hemodialysis patients with chronic renal failure]. | Nihon Jinzo Gakkai shi 20020501 |
| Antioxidative effects of fluvastatin on superoxide anion activated by angiotensin II in human aortic smooth muscle cells. | Cardiovascular drugs and therapy 20020501 |
| [Taking statins immediately after heart catheterization. Rate of complications is cut in half in diabetic patients]. | MMW Fortschritte der Medizin 20020404 |
| Effects of hypocholesterolaemic agents on the expression and activity of 3-hydroxy-3-methylglutaryl-CoA reductase in the fat body of the German cockroach. | Archives of insect biochemistry and physiology 20020401 |
| Fluvastatin reduces tissue factor expression and macrophage accumulation in carotid lesions of cholesterol-fed rabbits in the absence of lipid lowering. | Arteriosclerosis, thrombosis, and vascular biology 20020401 |
| Cholesterol-induced thrombogenicity of the vessel wall: inhibitory effect of fluvastatin. | Thrombosis and haemostasis 20020401 |
| Managing dyslipidemia in the high-risk patient. | The American journal of cardiology 20020307 |
| Pharmacokinetics of fluvastatin in subjects with renal impairment and nephrotic syndrome. | Journal of clinical pharmacology 20020301 |
| [Complete remission of minimal change nephrotic syndrome with type 2 diabetes mellitus treated by microemulsion formulation of cyclosporin and fluvastatin]. | Nihon Jinzo Gakkai shi 20020301 |
| [Stimulation of bone formation by anti-hyperlipidemic agent statins and its mechanism of action]. | Nihon rinsho. Japanese journal of clinical medicine 20020301 |
| HMG-CoA reductase inhibitors reduce interleukin-6 synthesis in human vascular smooth muscle cells. | Cardiovascular drugs and therapy 20020301 |
| Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction. | Circulation 20020219 |
| Fluvastatin enhances apoptosis in cytokine-stimulated vascular smooth muscle cells. | Journal of cardiovascular pharmacology 20020201 |
| 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis. | Gastroenterology 20020201 |
| Fluvastatin reduces modification of low-density lipoprotein in hyperlipidemic rabbit loaded with oxidative stress. | European journal of pharmacology 20020201 |
| Safety and efficacy of atorvastatin in heart transplant recipients. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20020201 |
| Lipid-lowering therapy with fluvastatin inhibits oxidative modification of low density lipoprotein and improves vascular endothelial function in hypercholesterolemic patients. | Atherosclerosis 20020201 |
| Effect of fluvastatin and pravastatin, HMG-CoA reductase inhibitors, on fluconazole activity against Candida albicans. | Journal of medical microbiology 20020201 |
| Electrochemical study of fluvastatin sodium--analytical application to pharmaceutical dosage forms, human serum, and simulated gastric juice. | Analytical and bioanalytical chemistry 20020201 |
| Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase. | FEBS letters 20020116 |
| Frequency of creatine kinase elevation during treatment with fluvastatin. | The American journal of cardiology 20020115 |
| Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB. | Biochemical and biophysical research communications 20020111 |
| Fluvastatin improves lipid abnormalities in patients with moderate to advanced chronic renal insufficiency. | American journal of kidney diseases : the official journal of the National Kidney Foundation 20020101 |
| Effects of fluvastatin treatment on insulin sensitivity in patients with hyperlipidaemia. | The Journal of international medical research 20020101 |
| The effect of fluvastatin on plasma fibrinogen levels. | Current medical research and opinion 20020101 |
| Effects of fluvastatin on homocysteine and serum lipids in kidney allograft recipients. | Annals of transplantation 20020101 |
| [Effect of fluvastain and its combination with aspirin and trental on hemostasis and microcirculation in atherosclerosis]. | Terapevticheskii arkhiv 20020101 |
| Acute pancreatitis induced by fluvastatin therapy. | Journal of clinical gastroenterology 20020101 |
| Plasma lipids and blood fluidity in patients with polygenic hypercholesterolaemia treated with fluvastatin. | Clinical hemorheology and microcirculation 20020101 |
| Neuromuscular toxicity in nephrotic patients treated with fluvastatin. | Journal of nephrology 20020101 |
| Stereoselective analysis of fluvastatin in human plasma for pharmacokinetic studies. | Journal of chromatography. B, Biomedical sciences and applications 20011205 |
| Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells. | Arteriosclerosis, thrombosis, and vascular biology 20011201 |
| Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype. | Arthritis and rheumatism 20011201 |
| Stability of atheromatous plaque affected by lesional composition: study of WHHL rabbits treated with statins. | Annals of the New York Academy of Sciences 20011201 |
| Antioxidative effects of fluvastatin and its metabolites against oxidative DNA damage in mammalian cultured cells. | Free radical research 20011201 |
| Fluvastatin depresses the enhanced lipid peroxidation in vitamin E-deficient hamsters. | Free radical research 20011201 |
| Effect of diet and treatment with statins on platelet-dependent thrombin generation in hypercholesterolemic subjects. | Nutrition, metabolism, and cardiovascular diseases : NMCD 20011201 |
| Effect of fluvastatin on acute renal allograft rejection: a randomized multicenter trial. | Kidney international 20011101 |
| Lovastatin increases nitric oxide synthesis in IL-1 beta-stimulated smooth muscle cells. | Chinese medical journal 20011101 |
| The use over time of statins in coronary patients in an Italian tertiary referral center. | Italian heart journal : official journal of the Italian Federation of Cardiology 20011101 |
| Effect of hydroxymethylglutaryl coenzyme a reductase inhibitors on the progression of calcific aortic stenosis. | Circulation 20011030 |
| Validated analysis of fluvastatin in a pharmaceutical capsule formulation and serum by capillary electrophoresis. | Biomedical chromatography : BMC 20011001 |
| The influence of plasma lipoprotein (a) on angiographic restenosis and coronary events in patients undergoing planned coronary balloon angioplasty. Ancillary analysis of the Fluvastatin Angioplasty Restenosis (FLARE) trial. | Atherosclerosis 20011001 |
| Managed care trends in statin usage. | Managed care (Langhorne, Pa.) 20011001 |
| Pharmacokinetics and pharmacodynamics of fluvastatin in heart transplant recipients taking cyclosporine A. | Journal of cardiovascular pharmacology and therapeutics 20011001 |
| Fluvastatin in combination with rad significantly reduces graft vascular disease in rat cardiac allografts. | Transplantation 20010927 |
| Lipid-independent effects of an estrogen-statin combination: inhibition of expression of adhesion molecules and plasminogen activator inhibitor--I in human endothelial cell cultures. | Climacteric : the journal of the International Menopause Society 20010901 |
| Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner. | Methods and findings in experimental and clinical pharmacology 20010901 |
| Determination of fluvastatin and its five metabolites in human plasma using simple gradient reversed-phase high-performance liquid chromatography with ultraviolet detection. | Journal of chromatography. B, Biomedical sciences and applications 20010825 |
| Achieving and maintaining National Cholesterol Education Program low-density lipoprotein cholesterol goals with five statins. | The American journal of medicine 20010815 |
| Inhibitory effects of fluvastain and its metabolites on the formation of several reactive oxygen species. | Life sciences 20010810 |
| Fluvastatin inhibits O2- and ICAM-1 levels in a rat model with aortic remodeling induced by pressure overload. | American journal of physiology. Heart and circulatory physiology 20010801 |
| Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins). | European journal of clinical pharmacology 20010801 |
| Fibromuscular cap composition is important for the stability of established atherosclerotic plaques in mature WHHL rabbits treated with statins. | Atherosclerosis 20010701 |
| Lipophilic statins augment inducible nitric oxide synthase expression in cytokine-stimulated cardiac myocytes. | Journal of cardiovascular pharmacology 20010701 |
| Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010701 |
| Effects of fluvastatin and its major metabolites on low-density lipoprotein oxidation and cholesterol esterification in macrophages. | Japanese journal of pharmacology 20010701 |
| Inhibition of epidermal growth factor-induced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors. | Cancer research 20010615 |
| Fluvastatin suppresses oxidative stress and fibrosis in the interstitium of mouse kidneys with unilateral ureteral obstruction. | Kidney international 20010601 |
| HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress. | Arteriosclerosis, thrombosis, and vascular biology 20010601 |
| LDL-receptor gene mutations and the hypocholesterolemic response to statin therapy. | Clinical genetics 20010601 |
| Plasma vascular endothelial growth factor and its receptor Flt-1 in patients with hyperlipidemia and atherosclerosis and the effects of fluvastatin or fenofibrate. | The American journal of cardiology 20010515 |
| Novel polymorphisms in promoter region of atp binding cassette transporter gene and plasma lipids, severity, progression, and regression of coronary atherosclerosis and response to therapy. | Circulation research 20010511 |
| Safety, tolerability, and pharmacokinetics of an extended-release formulation of fluvastatin administered once daily to patients with primary hypercholesterolemia. | Journal of cardiovascular pharmacology 20010501 |
| Effects of 1-year treatment with fluvastatin or pravastatin on bone. | The American journal of medicine 20010501 |
| Efficacy and safety of treatment with low-dose fluvastatin in hypercholesterolemic renal transplant recipients. | Transplantation proceedings 20010501 |
| Statin induced myopathy does not show up in MIBI scintigraphy. | Nuclear medicine communications 20010501 |
| A cost-effectiveness model of alternative statins to achieve target LDL-cholesterol levels. | International journal of clinical practice 20010501 |
| Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on nitric oxide-induced hydroxyl radical generation in the rat heart. | Biochimica et biophysica acta 20010430 |
| Fluvastatin lowers atherogenic dense low-density lipoproteins in postmenopausal women with the atherogenic lipoprotein phenotype. | Circulation 20010417 |
| Low-dose metoprolol CR/XL and fluvastatin slow progression of carotid intima-media thickness: Main results from the Beta-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS). | Circulation 20010403 |
| A HMG-CoA reductase inhibitor possesses a potent anti-atherosclerotic effect other than serum lipid lowering effects--the relevance of endothelial nitric oxide synthase and superoxide anion scavenging action. | Atherosclerosis 20010401 |
| Fluvastatin therapy improves microcirculation in patients with hyperlipidaemia. | Atherosclerosis 20010401 |
| Comparative study of HMG-CoA reductase inhibitors on fibrinogen. | Atherosclerosis 20010401 |
| Effect of fluvastatin on endothelium-dependent brachial artery vasodilation in patients after renal transplantation. | Kidney international 20010401 |
| Effects of fluvastatin on cardiac events in renal transplant patients: ALERT (Assessment of Lescol in Renal Transplantation) study design and baseline data. | Journal of cardiovascular risk 20010401 |
| Dose dependency of fluvastatin pharmacokinetics in serum determined by reversed phase HPLC. | Journal of cardiovascular pharmacology and therapeutics 20010401 |
| Cholesterol biosynthesis regulation and protein changes in rat liver following treatment with fluvastatin. | Toxicology letters 20010331 |
| Immunological response to oxidized LDL occurs in association with oxidative DNA damage independently of serum LDL concentrations in dyslipidemic patients. | Clinica chimica acta; international journal of clinical chemistry 20010301 |
| Statin therapy--what now? | Drug and therapeutics bulletin 20010301 |
| Effects of fluvastatin on biliary lipids in subjects with an elevated cholesterol saturation index. | European journal of clinical pharmacology 20010301 |
| A comparison of the efficacy and tolerability of titrate-to-goal regimens of simvastatin and fluvastatin: a randomized, double-blind study in adult patients at moderate to high risk for cardiovascular disease. | Clinical therapeutics 20010301 |
| [Fluvastatin]. | Nihon rinsho. Japanese journal of clinical medicine 20010301 |
| [Antioxidants]. | Nihon rinsho. Japanese journal of clinical medicine 20010301 |
| A clinical focus on statins. | Current opinion in investigational drugs (London, England : 2000) 20010301 |
| Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits. | Circulation 20010220 |
| A prospective study of paraoxonase gene Q/R192 polymorphism and severity, progression and regression of coronary atherosclerosis, plasma lipid levels, clinical events and response to fluvastatin. | Atherosclerosis 20010215 |
| Protective effect of fluvastatin on degradation of apolipoprotein B by a radical reaction in human plasma. | Biological & pharmaceutical bulletin 20010201 |
| Antioxidative effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes. | The Journal of pharmacy and pharmacology 20010201 |
| Regulation of endothelial nitric oxide synthase and endothelin-1 expression by fluvastatin in human vascular endothelial cells. | Japanese journal of pharmacology 20010201 |
| Efficacy and tolerability of fluvastatin extended-release delivery system: a pooled analysis. | Clinical therapeutics 20010201 |
| [The role of HDL in the prevention of cardiovascular events]. | Orvosi hetilap 20010121 |
| Effective use of statins to prevent coronary heart disease. | American family physician 20010115 |
| Statin trials in progress: unanswered questions. | Current atherosclerosis reports 20010101 |
| New statins and new doses of older statins. | Current atherosclerosis reports 20010101 |
| Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits. | Atherosclerosis 20010101 |
| [Antioxidative effects of fluvastatin, and its major metabolites [II]]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20010101 |
| Effects of fluvastatin and bezafibrate combination on plasma fibrinogen, t-plasminogen activator inhibitor and C reactive protein levels in coronary artery disease patients with mixed hyperlipidaemia (FACT Study)--a rebuttal. | Thrombosis and haemostasis 20010101 |
| Comparison of the efficacy and tolerability of fluvastatin extended-release and immediate-release formulations in the treatment of primary hypercholesterolemia: a randomized trial. | Clinical therapeutics 20010101 |
| Protective effects of fluvastatin against reactive oxygen species induced DNA damage and mutagenesis. | Free radical research 20010101 |
| Effect of an estrogen/statin combination on biochemical markers of endothelial function in human coronary artery cell cultures. | Menopause (New York, N.Y.) 20010101 |
| Clinical pharmacokinetics of fluvastatin. | Clinical pharmacokinetics 20010101 |
| Further evidence for direct vascular actions of statins: effect on endothelial nitric oxide synthase and adhesion molecules. | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20010101 |
| The effect of fluvastatin on parameters of bone remodeling. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20010101 |
| Newer HMG-CoA reductase inhibitor (statin) therapies. | Clinical cardiology 20010101 |
| Synthetic statins: more data on newer lipid-lowering agents. | Current medical research and opinion 20010101 |
| The effect of fluvastatin of hyperlipidemia in renal transplant recipients: a prospective, placebo-controlled study. | International urology and nephrology 20010101 |
| Effects of fluvastatin and bezafibrate combination on plasma fibrinogen, t-plasminogen activator inhibitor and C reactive protein levels in coronary artery disease patients with mixed hyperlipidaemia (FACT study). Fluvastatin Alone and in Combination Treatment. | Thrombosis and haemostasis 20000401 |
| Statin + fibrate combination therapy fluvastatin with bezafibrate or ciprofibrate in high risk patients with vascular disease. | International journal of cardiology 19990601 |
| The effects of fluvastatin, a CYP2C9 inhibitor, on losartan pharmacokinetics in healthy volunteers. | Journal of clinical pharmacology 19990401 |
| Two different types of exercise-induced muscle pain without myopathy and CK-elevation during HMG-Co-enzyme-A-reductase inhibitor treatment. | Atherosclerosis 19990401 |
| In vitro activity of fluvastatin, a cholesterol-lowering agent, and synergy with flucanazole and itraconazole against Candida species and Cryptococcus neoformans. | Antimicrobial agents and chemotherapy 19970401 |
| Effect of fluvastatin or bezafibrate on the distribution of high density lipoprotein subpopulations in patients with familial hypercholesterolemia. | Arzneimittel-Forschung 19960901 |
| Fluvastatin in combination with other lipid-lowering agents. | British journal of clinical practice. Supplement 19960101 |
| Efficacy and safety of triple therapy (fluvastatin-bezafibrate-cholestyramine) for severe familial hypercholesterolemia. | The American journal of cardiology 19950713 |
| Treatment of primary hypercholesterolemia: fluvastatin versus bezafibrate. | The American journal of medicine 19940606 |
| Efficacy and safety of a combination fluvastatin-bezafibrate treatment for familial hypercholesterolemia: comparative analysis with a fluvastatin-cholestyramine combination. | The American journal of medicine 19940501 |
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