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Home > Fluorides > 155204-26-5
155204-26-5 | Benzamide, 4-fluoro-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-
CAS No: 155204-26-5 Catalog No: AG001NQB MDL No:
Product Description
Catalog Number:
AG001NQB
Chemical Name:
Benzamide, 4-fluoro-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-
CAS Number:
155204-26-5
Molecular Formula:
C25H27FN4O2
Molecular Weight:
434.5059
IUPAC Name:
4-fluoro-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbenzamide
InChI:
InChI=1S/C25H27FN4O2/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20/h2-13H,14-19H2,1H3
InChI Key:
YJZYDPRMWYWYCG-UHFFFAOYSA-N
SMILES:
COc1ccccc1N1CCN(CC1)CCN(C(=O)c1ccc(cc1)F)c1ccccn1
UNII:
81KHI46E5L
Properties
Complexity:
578
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
434.212g/mol
Formal Charge:
0
Heavy Atom Count:
32
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
434.515g/mol
Monoisotopic Mass:
434.212g/mol
Rotatable Bond Count:
7
Topological Polar Surface Area:
48.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.9
Literature
| Title | Journal |
|---|---|
| Role of serotonergic 1A receptor dysfunction in depression associated with Parkinson's disease. | Movement disorders : official journal of the Movement Disorder Society 20120101 |
| Organic background of restrictive-type anorexia nervosa suggested by increased serotonin 1A receptor binding in right frontotemporal cortex of both lean and recovered patients: [18F]MPPF PET scan study. | Biological psychiatry 20081201 |
| Activation of the serotonergic 5-HT1A receptor in the paraventricular nucleus of the hypothalamus inhibits water intake and increases urinary excretion in water-deprived rats. | Regulatory peptides 20081009 |
| Comorbidity between temporal lobe epilepsy and depression: a [18F]MPPF PET study. | Brain : a journal of neurology 20081001 |
| PET imaging of brain 5-HT1A receptors in the preoperative evaluation of temporal lobe epilepsy. | Brain : a journal of neurology 20081001 |
| Characterization of 4-(2-hydroxyphenyl)-1-[2'-[N-(2''-pyridinyl)-p-fluorobenzamido]ethyl]piperazine (p-DMPPF) as a new potent 5-HT1A antagonist. | British journal of pharmacology 20071101 |
| Analysis of 18F-labelled synthesis products on TLC plates: comparison of radioactivity scanning, film autoradiography, and a phosphoimaging technique. | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20060901 |
| Radiochemical synthesis and tissue distribution of p-[18F]DMPPF, a new 5-HT1A ligand for PET, in rats. | Nuclear medicine and biology 20060701 |
| Prolonged treatment with ligands affects ligand binding to the human serotonin(1A) receptor in Chinese hamster ovary cells. | Cellular and molecular neurobiology 20060501 |
| Cholesterol modulates the antagonist-binding function of hippocampal serotonin1A receptors. | Biochimica et biophysica acta 20050801 |
| The 5-HT1A receptor modulates the effects of cocaine on extracellular serotonin and dopamine levels in the nucleus accumbens. | European journal of pharmacology 20050131 |
| G-protein-dependent cell surface dynamics of the human serotonin1A receptor tagged to yellow fluorescent protein. | Biochemistry 20041221 |
| Tryptophan depletion and serotonin loss in selective serotonin reuptake inhibitor-treated depression: an [(18)F] MPPF positron emission tomography study. | Biological psychiatry 20041015 |
| 5-HT1A receptor binding and intracerebral activity in temporal lobe epilepsy: an [18F]MPPF-PET study. | Brain : a journal of neurology 20040401 |
| Ligand binding characteristics of the human serotonin1A receptor heterologously expressed in CHO cells. | Bioscience reports 20040401 |
| Displacement of the PET ligand 18F-MPPF by the electrically evoked serotonin release in the rat hippocampus. | Synapse (New York, N.Y.) 20030915 |
| An in vitro assay for predicting successful imaging radiotracers. | Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20030101 |
| 5-HT(1A) receptor imaging in the human brain: effect of tryptophan depletion and infusion on [(18)F]MPPF binding. | Synapse (New York, N.Y.) 20021101 |
| 5-HT1A receptor-mediated regulation of mitogen-activated protein kinase phosphorylation in rat brain. | European journal of pharmacology 20021004 |
| Regulation of the avidity of ternary complexes containing the human 5-HT(1A) receptor by mutation of a receptor contact site on the interacting G protein alpha subunit. | British journal of pharmacology 20021001 |
| The potential of the beta-Microprobe, an intracerebral radiosensitive probe, to monitor the [(18)F]MPPF binding in the rat dorsal raphe nucleus. | European journal of nuclear medicine and molecular imaging 20020901 |
| Modeling [18 F]MPPF positron emission tomography kinetics for the determination of 5-hydroxytryptamine(1A) receptor concentration with multiinjection. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020601 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Quantification of 5-HT(1A) receptors in human brain using p-MPPF kinetic modelling and PET. | European journal of nuclear medicine and molecular imaging 20020101 |
| Comparative study of hippocampal neuronal loss and in vivo binding of 5-HT1a receptors in the KA model of limbic epilepsy in the rat. | Epilepsy research 20011101 |
| Modulation of antagonist binding to serotonin1A receptors from bovine hippocampus by metal ions. | Cellular and molecular neurobiology 20011001 |
| On the quantification of [18F]MPPF binding to 5-HT1A receptors in the human brain. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20010701 |
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