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155204-23-2 | 4-IODO-N-[2-[4-(METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-BENZAMIDE HYDROCHLORIDE
CAS No: 155204-23-2 Catalog No: AG00AKFI MDL No:
Product Description
Catalog Number:
AG00AKFI
Chemical Name:
4-IODO-N-[2-[4-(METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-BENZAMIDE HYDROCHLORIDE
CAS Number:
155204-23-2
IUPAC Name:
4-iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbenzamide
InChI:
InChI=1S/C25H27IN4O2/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20/h2-13H,14-19H2,1H3
InChI Key:
DHMLNZRDVQLQBB-UHFFFAOYSA-N
Properties
Complexity:
578
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
542.118g/mol
Formal Charge:
0
Heavy Atom Count:
32
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
542.421g/mol
Monoisotopic Mass:
542.118g/mol
Rotatable Bond Count:
7
Topological Polar Surface Area:
48.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.5
Literature
| Title | Journal |
|---|---|
| Augmentative effect of spinosin on pentobarbital-induced loss of righting reflex in mice associated with presynaptic 5-HT1A receptor. | The Journal of pharmacy and pharmacology 20120201 |
| Anxiolytic effects of 5-HT₁A receptors and anxiogenic effects of 5-HT₂C receptors in the amygdala of mice. | Neuropharmacology 20120101 |
| Role of 5-HT(1A) and 5-HT(1B) receptors in the antidepressant-like effect of piperine in the forced swim test. | Neuroscience letters 20111024 |
| Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT(1A) receptors. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20100501 |
| Peripheral and central mediators of lipopolysaccharide induced suppression of defensive rage behavior in the cat. | Neuroscience 20091110 |
| Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A receptor. | Neuroscience letters 20091106 |
| Serotonin, social status and sex change in the bluebanded goby Lythrypnus dalli. | Physiology & behavior 20090622 |
| Increased extracellular 5-HT but no change in sleep after perfusion of a 5-HT1A antagonist into the dorsal raphe nucleus of rats. | Acta physiologica (Oxford, England) 20080501 |
| Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: behavioural and electrophysiological studies. | European journal of pharmacology 20050711 |
| Paroxetine combined with a 5-HT(1A) receptor antagonist reversed reward deficits observed during amphetamine withdrawal in rats. | Psychopharmacology 20050301 |
| Ligand binding characteristics of the human serotonin1A receptor heterologously expressed in CHO cells. | Bioscience reports 20040401 |
| Differential modulation of feline defensive rage behavior in the medial hypothalamus by 5-HT1A and 5-HT2 receptors. | Brain research 20030815 |
| Effect of different 5-HT1A receptor antagonists in combination with paroxetine on expression of the immediate-early gene Arc in rat brain. | Neuropharmacology 20030601 |
| Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030515 |
| Involvement of the 5-HT(1A) and 5-HT(1B) serotonergic receptor subtypes in sexual arousal in male mice. | Psychoneuroendocrinology 20020701 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| 5-HT(1A) receptor antagonist p-MPPI attenuates acute ethanol effects in mice and rats. | Neuroscience letters 20020329 |
| Neuroepithelial bodies in mammalian lung express functional serotonin type 3 receptor. | American journal of physiology. Lung cellular and molecular physiology 20011001 |
| Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010701 |
| The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. | Behavioural brain research 20010601 |
| Sleep and waking following microdialysis perfusion of the selective 5-HT1A receptor antagonist p-MPPI into the dorsal raphe nucleus in the freely moving rat. | Brain research 20010406 |
| Serotonergic manipulations both potentiate and reduce brain stimulation reward in rats: involvement of serotonin-1A receptors. | The Journal of pharmacology and experimental therapeutics 20010401 |
| 5-HT(1A) receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission. | Journal of neurochemistry 20010401 |
| Effect of different 5-hydroxytryptamine receptor subtype antagonists on the micturition reflex in rats. | BJU international 20010201 |
| Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors. | The Journal of pharmacology and experimental therapeutics 20000201 |
| Serotonin1B receptor stimulation enhances cocaine reinforcement. | The Journal of neuroscience : the official journal of the Society for Neuroscience 19981201 |
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