200,000+ products from a single source!
sales@angenechem.com
155-54-4 | 4-Pyrimidinecarboxylic acid, hexahydro-2,6-dioxo-
CAS No: 155-54-4 Catalog No: AG001NJM MDL No:MFCD00006030
Product Description
Catalog Number:
AG001NJM
Chemical Name:
4-Pyrimidinecarboxylic acid, hexahydro-2,6-dioxo-
CAS Number:
155-54-4
Molecular Formula:
C5H6N2O4
Molecular Weight:
158.1121
MDL Number:
MFCD00006030
IUPAC Name:
2,6-dioxo-1,3-diazinane-4-carboxylic acid
InChI:
InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)
InChI Key:
UFIVEPVSAGBUSI-UHFFFAOYSA-N
SMILES:
O=C1NC(=O)NC(C1)C(=O)O
Properties
Complexity:
225
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
158.033g/mol
Formal Charge:
0
Heavy Atom Count:
11
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
158.113g/mol
Monoisotopic Mass:
158.033g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
95.5A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.5
Literature
| Title | Journal |
|---|---|
| Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients. | Bioscience reports 20121201 |
| Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening. | Journal of medicinal chemistry 20121011 |
| Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH. | Human molecular genetics 20120915 |
| Vidofludimus inhibits colonic interleukin-17 and improves hapten-induced colitis in rats by a unique dual mode of action. | The Journal of pharmacology and experimental therapeutics 20120901 |
| D282, a non-nucleoside inhibitor of influenza virus infection that interferes with de novo pyrimidine biosynthesis. | Antiviral chemistry & chemotherapy 20120821 |
| Crystal structure of dihydroorotate dehydrogenase from Leishmania major. | Biochimie 20120801 |
| Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii. | Molecular and biochemical parasitology 20120801 |
| New trifluoromethyl triazolopyrimidines as anti-Plasmodium falciparum agents. | Molecules (Basel, Switzerland) 20120710 |
| Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases. | Journal of medicinal chemistry 20120628 |
| Immunosuppression with 4SC-101, a novel inhibitor of dihydroorotate dehydrogenase, in a rat model of renal transplantation. | Transplantation 20120615 |
| Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. | British journal of pharmacology 20120601 |
| Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug. | The Journal of infectious diseases 20120415 |
| Genetic dissection of pyrimidine biosynthesis and salvage in Leishmania donovani. | The Journal of biological chemistry 20120413 |
| Renal involvement in mitochondrial cytopathies. | Pediatric nephrology (Berlin, Germany) 20120401 |
| Leflunomide in dermatology. | Journal of the American Academy of Dermatology 20120401 |
| Lack of association between CAG repeat polymorphism in the androgen receptor gene and the outcome of rheumatoid arthritis treatment with leflunomide. | European journal of clinical pharmacology 20120401 |
| Current advances in detection and treatment of babesiosis. | Current medicinal chemistry 20120401 |
| Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs. | PLoS neglected tropical diseases 20120401 |
| Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression. | The Journal of biological chemistry 20120323 |
| Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2). | Journal of medicinal chemistry 20120308 |
| Evidence supporting a role for dihydroorotate dehydrogenase, bioenergetics, and p53 in selective teriflunomide-induced apoptosis in transformed versus normal human keratinocytes. | Apoptosis : an international journal on programmed cell death 20120301 |
| Back to the future: lessons learned in modern target-based and whole-cell lead optimization of antimalarials. | Current topics in medicinal chemistry 20120301 |
| New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold. | European journal of medicinal chemistry 20120301 |
| An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors. | Human molecular genetics 20120201 |
| Leflunomide induces apoptosis in fludarabine-resistant and clinically refractory CLL cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20120115 |
| Gene orders in the upstream of 16S rRNA genes divide genera of the family Halobacteriaceae into two groups. | International journal of systematic and evolutionary microbiology 20120101 |
| Mitochondria-ros crosstalk in the control of cell death and aging. | Journal of signal transduction 20120101 |
| The transcriptome of compatible and incompatible interactions of potato (Solanum tuberosum) with Phytophthora infestans revealed by DeepSAGE analysis. | PloS one 20120101 |
| Interkingdom gene transfer may contribute to the evolution of phytopathogenicity in botrytis cinerea. | Evolutionary bioinformatics online 20120101 |
| Reconstruction and analysis of a genome-scale metabolic model for Scheffersomyces stipitis. | Microbial cell factories 20120101 |
| Effects of inhibiting CoQ10 biosynthesis with 4-nitrobenzoate in human fibroblasts. | PloS one 20120101 |
| P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action. | PloS one 20120101 |
| The Chlamydia psittaci genome: a comparative analysis of intracellular pathogens. | PloS one 20120101 |
| Novel Pharmacological Approaches for Inflammatory Bowel Disease: Targeting Key Intracellular Pathways and the IL-23/IL-17 Axis. | International journal of inflammation 20120101 |
| Sequence and analysis of the genome of the pathogenic yeast Candida orthopsilosis. | PloS one 20120101 |
| An alternative paradigm for the role of antimalarial plants in Africa. | TheScientificWorldJournal 20120101 |
| SUMOylation of paraflagellar rod protein, PFR1, and its stage-specific localization in Trypanosoma cruzi. | PloS one 20120101 |
| Recent progress in synthetic biology for microbial production of C3-C10 alcohols. | Frontiers in microbiology 20120101 |
| Biaryl analogues of teriflunomide as potent DHODH inhibitors. | Bioorganic & medicinal chemistry letters 20111215 |
| Finding disease variants in Mendelian disorders by using sequence data: methods and applications. | American journal of human genetics 20111209 |
| Immunosuppressive effects and mechanisms of leflunomide in dengue virus infection of human dendritic cells. | Journal of clinical immunology 20111201 |
| Knockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge. | PLoS neglected tropical diseases 20111201 |
| A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor. | ACS chemical biology 20111118 |
| Potent antiviral activity of brequinar against the emerging Cantagalo virus in cell culture. | International journal of antimicrobial agents 20111101 |
| Site directed spin labeling studies of Escherichia coli dihydroorotate dehydrogenase N-terminal extension. | Biochemical and biophysical research communications 20111028 |
| Oxygen reactivity in flavoenzymes: context matters. | Journal of the American Chemical Society 20111026 |
| Randomized trial of oral teriflunomide for relapsing multiple sclerosis. | The New England journal of medicine 20111006 |
| Recent developments in the medicinal chemistry and therapeutic potential of dihydroorotate dehydrogenase (DHODH) inhibitors. | Mini reviews in medicinal chemistry 20111001 |
| The next opportunity in anti-malaria drug discovery: the liver stage. | PLoS pathogens 20110901 |
| Expressed sequence tag analysis of the erythrocytic stage of Plasmodium berghei. | The Korean journal of parasitology 20110901 |
| Multiple sclerosis: pathogenesis and treatment. | Current neuropharmacology 20110901 |
| Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function. | Eukaryotic cell 20110801 |
| Miller syndrome with novel dihydroorotate dehydrogenase gene mutations. | Pediatrics international : official journal of the Japan Pediatric Society 20110801 |
| Arabidopsis thaliana nucleosidase mutants provide new insights into nucleoside degradation. | The New phytologist 20110701 |
| [Pharmacological targets in multiple sclerosis]. | Revista de neurologia 20110701 |
| Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. | Journal of medicinal chemistry 20110609 |
| Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection. | Molecular and biochemical parasitology 20110501 |
| Identification of the UMP synthase gene by establishment of uracil auxotrophic mutants and the phenotypic complementation system in the marine diatom Phaeodactylum tricornutum. | Plant physiology 20110501 |
| Substrate binding and reactivity are not linked: grafting a proton-transfer network into a Class 1A dihydroorotate dehydrogenase. | Biochemistry 20110412 |
| Extra phenotypic features in a girl with Miller syndrome. | Clinical dysmorphology 20110401 |
| DHODH modulates transcriptional elongation in the neural crest and melanoma. | Nature 20110324 |
| Metabolic regulation by p53. | Journal of molecular medicine (Berlin, Germany) 20110301 |
| Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans. | Acta crystallographica. Section F, Structural biology and crystallization communications 20110201 |
| 1,2,5-Oxadiazole analogues of leflunomide and related compounds. | European journal of medicinal chemistry 20110101 |
| Global response of Plasmodium falciparum to hyperoxia: a combined transcriptomic and proteomic approach. | Malaria journal 20110101 |
| The discovery of potential acetylcholinesterase inhibitors: a combination of pharmacophore modeling, virtual screening, and molecular docking studies. | Journal of biomedical science 20110101 |
| Human dihydroorotate dehydrogenase inhibitors, a novel approach for the treatment of autoimmune and inflammatory diseases. | Arzneimittel-Forschung 20110101 |
| Diurnal rhythms result in significant changes in the cellular protein complement in the cyanobacterium Cyanothece 51142. | PloS one 20110101 |
| The importance of mitochondrial DNA in aging and cancer. | Journal of aging research 20110101 |
| Enzyme Mechanism and Slow-Onset Inhibition of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase by an Inorganic Complex. | Enzyme research 20110101 |
| Development of oral immunomodulatory agents in the management of multiple sclerosis. | Drug design, development and therapy 20110101 |
| Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus. | PloS one 20110101 |
| 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. | International journal of molecular sciences 20110101 |
| Global transcriptome response in Lactobacillus sakei during growth on ribose. | BMC microbiology 20110101 |
| Complete genome sequence of the filamentous anoxygenic phototrophic bacterium Chloroflexus aurantiacus. | BMC genomics 20110101 |
| Decrease of energy spilling in Escherichia coli continuous cultures with rising specific growth rate and carbon wasting. | BMC systems biology 20110101 |
| Comparative genomics and transcriptomics of Propionibacterium acnes. | PloS one 20110101 |
| Transcription Profiling of the Model Cyanobacterium Synechococcus sp. Strain PCC 7002 by Next-Gen (SOLiD™) Sequencing of cDNA. | Frontiers in microbiology 20110101 |
| Manganese superoxide dismutase: guardian of the powerhouse. | International journal of molecular sciences 20110101 |
| An essential farnesylated kinesin in Trypanosoma brucei. | PloS one 20110101 |
| Drugs for malaria: something old, something new, something borrowed. | F1000 biology reports 20110101 |
| Evolutionary and functional insights into Leishmania META1: evidence for lateral gene transfer and a role for META1 in secretion. | BMC evolutionary biology 20110101 |
| The hydroxyl functional group of N-(4-hydroxyphenyl)retinamide mediates cellular uptake and cytotoxicity in premalignant and malignant human epithelial cells. | Free radical biology & medicine 20101215 |
| Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis. | Cell death and differentiation 20101201 |
| Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies. | Molecular and biochemical parasitology 20101201 |
| Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery. | European journal of medicinal chemistry 20101201 |
| Metabolism of [U-(13)C]aspartate by astroglial cultures: nuclear magnetic resonance analysis of the culture media. | Neurochemical research 20101201 |
| Protoporphyrinogen IX oxidase from Plasmodium falciparum is anaerobic and is localized to the mitochondrion. | Molecular and biochemical parasitology 20101101 |
| Teriflunomide, an inhibitor of dihydroorotate dehydrogenase for the potential oral treatment of multiple sclerosis. | Current opinion in investigational drugs (London, England : 2000) 20101101 |
| Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. | The Journal of biological chemistry 20101022 |
| 4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease. | Inflammatory bowel diseases 20101001 |
| Chemometric modeling, docking and in silico design of triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors as antimalarials. | European journal of medicinal chemistry 20101001 |
| Leflunomide: a drug with a potential beyond rheumatology. | Immunotherapy 20100901 |
| Effect of carbon source on pyrimidine biosynthesis in Pseudomonas oryzihabitans. | Journal of basic microbiology 20100801 |
| An N-(alkylcarbonyl)anthranilic acid derivative prolongs cardiac allograft survival synergistically with cyclosporine A in a high-responder rat model. | Transplant immunology 20100801 |
| Identification and characterization of a putative dihydroorotase, KPN01074, from Klebsiella pneumoniae. | The protein journal 20100801 |
| Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis. | Free radical biology & medicine 20100701 |
| Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy. | Infectious disorders drug targets 20100601 |
| 4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL-(Fas)lpr mice. | The American journal of pathology 20100601 |
| Region-specific distribution of dihydroorotate dehydrogenase in the rat central nervous system points to pyrimidine de novo synthesis in neurons. | Nucleosides, nucleotides & nucleic acids 20100601 |
| Analysis of genetic inheritance in a family quartet by whole-genome sequencing. | Science (New York, N.Y.) 20100430 |
| Genetics of neurodegenerative diseases: insights from high-throughput resequencing. | Human molecular genetics 20100415 |
| Inhibition of human DHODH by 4-hydroxycoumarins, fenamic acids, and N-(alkylcarbonyl)anthranilic acids identified by structure-guided fragment selection. | ChemMedChem 20100406 |
| Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry. | Analytical biochemistry 20100401 |
| Constitutive NADPH-dependent electron transferase activity of the Nox4 dehydrogenase domain. | Biochemistry 20100323 |
| Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures. | Bioorganic & medicinal chemistry letters 20100315 |
| Control of pyrimidine nucleotide formation in Pseudomonas fulva. | Antonie van Leeuwenhoek 20100301 |
| A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH. | Bioorganic & medicinal chemistry letters 20100201 |
| Microaerophilic respiratory metabolism of Plasmodium falciparum mitochondrion as a drug target. | Current molecular medicine 20100201 |
| Microarray analysis of Leflunomide-induced limb malformations in CD-1 mice. | Reproductive toxicology (Elmsford, N.Y.) 20100101 |
| Exome sequencing identifies the cause of a mendelian disorder. | Nature genetics 20100101 |
| Exome sequencing makes medical genomics a reality. | Nature genetics 20100101 |
| Global transcriptomic response of Leptospira interrogans serovar Copenhageni upon exposure to serum. | BMC microbiology 20100101 |
| Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution. | Biology direct 20100101 |
| Inhibitors of the mitochondrial electron transport chain and de novo pyrimidine biosynthesis as antimalarials: The present status. | Current medicinal chemistry 20100101 |
| The Alveolate Perkinsus marinus: biological insights from EST gene discovery. | BMC genomics 20100101 |
| Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells. | Molecular cancer 20100101 |
| Plasmodium falciparum proteome changes in response to doxycycline treatment. | Malaria journal 20100101 |
| Management of ANCA-associated vasculitis: Current trends and future prospects. | Therapeutics and clinical risk management 20100101 |
| Comparison of koala LPCoLN and human strains of Chlamydia pneumoniae highlights extended genetic diversity in the species. | BMC genomics 20100101 |
| New method for selection of hydrogen peroxide adapted bifidobacteria cells using continuous culture and immobilized cell technology. | Microbial cell factories 20100101 |
| The effect of leflunomide on cycling and activation of T-cells in HIV-1-infected participants. | PloS one 20100101 |
| Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis. | BMC systems biology 20100101 |
| Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. | Molecular systems biology 20100101 |
| Emerging oral treatments in multiple sclerosis - clinical utility of cladribine tablets. | Therapeutics and clinical risk management 20100101 |
| The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism. | Journal of nucleic acids 20100101 |
| Influence of long-term leflunomide treatment on serum amyloid concentration in rheumatoid arthritis patients. | Pharmacological reports : PR 20100101 |
| The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. | PloS one 20100101 |
| Directly-observed therapy (DOT) for the radical 14-day primaquine treatment of Plasmodium vivax malaria on the Thai-Myanmar border. | Malaria journal 20100101 |
| Uridine metabolism in HIV-1-infected patients: effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome. | PloS one 20100101 |
| New approaches in the management of multiple sclerosis. | Drug design, development and therapy 20100101 |
| Complex and multidimensional lipid raft alterations in a murine model of Alzheimer's disease. | International journal of Alzheimer's disease 20100101 |
| Emerging therapies for treatment of multiple sclerosis. | Journal of inflammation research 20100101 |
| Disruption of the proton relay network in the class 2 dihydroorotate dehydrogenase from Escherichia coli. | Biochemistry 20091020 |
| Inhibition of tumour necrosis factor and IL-17 production by leflunomide involves the JAK/STAT pathway. | Annals of the rheumatic diseases 20091001 |
| Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. | The Journal of biological chemistry 20090925 |
| The OsDHODH1 gene is involved in salt and drought tolerance in rice. | Journal of integrative plant biology 20090901 |
| [Development of anti-trypanosome drugs targeting nucleotides biosynthesis and red-ox regulatory pathway]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20090901 |
| Roles in binding and chemistry for conserved active site residues in the class 2 dihydroorotate dehydrogenase from Escherichia coli. | Biochemistry 20090804 |
| Converting NADH to NAD+ by nicotinamide nucleotide transhydrogenase as a novel strategy against mitochondrial pathologies during aging. | Biogerontology 20090801 |
| Dihydroorotate dehydrogenase polymorphism influences the toxicity of leflunomide treatment in patients with rheumatoid arthritis. | Annals of the rheumatic diseases 20090801 |
| Advancing drug innovation for neglected diseases-criteria for lead progression. | PLoS neglected tropical diseases 20090801 |
| A functional analysis of the pyrimidine catabolic pathway in Arabidopsis. | The New phytologist 20090701 |
| Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. | Journal of medicinal chemistry 20090514 |
| Fitness of Escherichia coli during urinary tract infection requires gluconeogenesis and the TCA cycle. | PLoS pathogens 20090501 |
| Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. | Journal of medicinal chemistry 20090409 |
| Inhibiting the teratogenicity of the immunosuppressant leflunomide in mice by supplementation of exogenous uridine. | Toxicological sciences : an official journal of the Society of Toxicology 20090401 |
| [F01WB-1315 A and B, two dihydroorotate dehydrogenase inhibitors from microbial metabolites]. | Wei sheng wu xue bao = Acta microbiologica Sinica 20090401 |
| Dihydroorotase from the hyperthermophile Aquifex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis. | Biochemistry 20090203 |
| Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. | Bioorganic & medicinal chemistry letters 20090201 |
| Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells. | Molecular cancer therapeutics 20090201 |
| The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide. | Pharmacogenomics 20090201 |
| Factors accelerating pyrimidine production in Deinococcus radiophilus. | Archives of microbiology 20090101 |
| How mitochondria produce reactive oxygen species. | The Biochemical journal 20090101 |
| Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. | Journal of neurology 20090101 |
| The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications. | PloS one 20090101 |
| Recent developments in anti-rheumatic drugs in pediatrics: treatment of juvenile idiopathic arthritis. | Arthritis research & therapy 20090101 |
| Evaluation of high efficiency gene knockout strategies for Trypanosoma cruzi. | BMC microbiology 20090101 |
| Review of teriflunomide and its potential in the treatment of multiple sclerosis. | Neuropsychiatric disease and treatment 20090101 |
| Insertion of horizontally transferred genes within conserved syntenic regions of yeast genomes. | PloS one 20090101 |
| Structural analysis of polarizing indels: an emerging consensus on the root of the tree of life. | Biology direct 20090101 |
| Gene responses to oxygen availability in Kluyveromyces lactis: an insight on the evolution of the oxygen-responding system in yeast. | PloS one 20090101 |
| Recent developments in multiple sclerosis therapeutics. | BMC medicine 20090101 |
| A comprehensive review of immunosuppression used for liver transplantation. | Journal of transplantation 20090101 |
| New oral disease-modifying therapies for multiple sclerosis. | F1000 medicine reports 20090101 |
| Kynurenine pathway metabolites in humans: disease and healthy States. | International journal of tryptophan research : IJTR 20090101 |
| Suppression of immunoglobulin production by a novel dihydroorotate dehydrogenase inhibitor, S-2678. | European journal of pharmacology 20081228 |
| Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. | The Journal of biological chemistry 20081212 |
| Evidence for a new root of the tree of life. | Systematic biology 20081201 |
| Interaction model based on local protein substructures generalizes to the entire structural enzyme-ligand space. | Journal of chemical information and modeling 20081101 |
| Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction. | Biochemistry 20081014 |
| Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways. | The EMBO journal 20080917 |
| The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites. | Biochemistry 20080826 |
| Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum. | Journal of medicinal chemistry 20080626 |
| Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase from Y strain. | Biochemical and biophysical research communications 20080509 |
| Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies. | Molecular microbiology 20080401 |
| The immunomodulatory drug Leflunomide inhibits cell cycle progression of B-CLL cells. | Leukemia 20080301 |
| Defects in vesicle core induced by escherichia coli dihydroorotate dehydrogenase. | Biophysical journal 20080301 |
| Pyrimidine nucleoside depletion sensitizes to the mitochondrial hepatotoxicity of the reverse transcriptase inhibitor stavudine. | The American journal of pathology 20080301 |
| Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase. | Biochemistry 20080226 |
| Nucleotide biosynthesis is critical for growth of bacteria in human blood. | PLoS pathogens 20080201 |
| In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand. | Malaria journal 20080101 |
| Theoretical investigation of the reaction mechanism of the dinuclear zinc enzyme dihydroorotase. | Chemistry (Weinheim an der Bergstrasse, Germany) 20080101 |
| Metabolic pathways of the wheat (Triticum aestivum) endosperm amyloplast revealed by proteomics. | BMC plant biology 20080101 |
| Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX. | PloS one 20080101 |
| Evidence of recent interkingdom horizontal gene transfer between bacteria and Candida parapsilosis. | BMC evolutionary biology 20080101 |
| Global regulation of nucleotide biosynthetic genes by c-Myc. | PloS one 20080101 |
| Remodeling of the Streptococcus agalactiae transcriptome in response to growth temperature. | PloS one 20080101 |
| Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate. | BMC genomics 20080101 |
| Heterologous expression of plasmodial proteins for structural studies and functional annotation. | Malaria journal 20080101 |
| Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism. | BMC genomics 20080101 |
| Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells. | Journal of immunology (Baltimore, Md. : 1950) 20071115 |
| Regulation of pyrimidine nucleotide biosynthesis in Pseudomonas synxantha. | Antonie van Leeuwenhoek 20071001 |
| Regulation of pyrimidine formation in Pseudomonas oryzihabitans. | Journal of basic microbiology 20071001 |
| Dihydroorotate dehydrogenase from Saccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues. | FEMS yeast research 20070901 |
| Evidence for a gram-positive, eubacterial root of the tree of life. | Molecular biology and evolution 20070801 |
| Mutations in yhiT enable utilization of exogenous pyrimidine intermediates in Salmonella enterica serovar Typhimurium. | Microbiology (Reading, England) 20070801 |
| Dihydroorotate dehydrogenase arises from novel fused gene product with aspartate carbamoyltransferase in Bodo saliens. | Biochemical and biophysical research communications 20070622 |
| On itinerant water molecules and detectability of protein-protein interfaces through comparative analysis of homologues. | Journal of molecular biology 20070601 |
| Interaction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactis. | Biochemistry 20070515 |
| Detergent-dependent kinetics of truncated Plasmodium falciparum dihydroorotate dehydrogenase. | The Journal of biological chemistry 20070427 |
| Mechanism of flavin reduction in the class 1A dihydroorotate dehydrogenase from Lactococcus lactis. | Biochemistry 20070403 |
| Mitochondrial DNA-deficient models and aging. | Annals of the New York Academy of Sciences 20070401 |
| Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. | Nature 20070301 |
| Dicoumarol impairs mitochondrial electron transport and pyrimidine biosynthesis in human myeloid leukemia HL-60 cells. | Biochemical pharmacology 20070201 |
| Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase. | Journal of medicinal chemistry 20070125 |
| Kappa-alpha plot derived structural alphabet and BLOSUM-like substitution matrix for rapid search of protein structure database. | Genome biology 20070101 |
| High-throughput identification of interacting protein-protein binding sites. | BMC bioinformatics 20070101 |
| Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases. | Biochemistry 20061219 |
| Enzyme inhibition potency enhancement by active site metal chelating and hydrogen bonding induced conformation-restricted cyclopropanecarbonyl derivatives. | Bioorganic & medicinal chemistry letters 20061201 |
| Dynamics of the cellular metabolome during human cytomegalovirus infection. | PLoS pathogens 20061201 |
| Hydrogen bonding pathways in human dihydroorotate dehydrogenase. | The journal of physical chemistry. B 20061005 |
| Crystallization and preliminary X-ray diffraction analysis of Leishmania major dihydroorotate dehydrogenase. | Acta crystallographica. Section F, Structural biology and crystallization communications 20061001 |
| Immunosuppression: today, tomorrow, and withdrawal. | Seminars in liver disease 20060801 |
| Thermodynamic analysis of catalysis by the dihydroorotases from hamster and Bacillus caldolyticus, as compared with the uncatalyzed reaction. | Biochemistry 20060711 |
| Cloning, expression, purification, and characterization of Leishmania major dihydroorotate dehydrogenase. | Protein expression and purification 20060701 |
| Biochemical characterization of recombinant dihydroorotate dehydrogenase from the opportunistic pathogenic yeast Candida albicans. | The FEBS journal 20060701 |
| Lys-D48 is required for charge stabilization, rapid flavin reduction, and internal electron transfer in the catalytic cycle of dihydroorotate dehydrogenase B of Lactococcus lactis. | The Journal of biological chemistry 20060630 |
| 13C and 15N isotope effects for conversion of L-dihydroorotate to N-carbamyl-L-aspartate using dihydroorotase from hamster and Bacillus caldolyticus. | Biochemistry 20060613 |
| 4SCan/vADME: intelligent library screening as a shortcut from hits to lead compounds. | Expert opinion on drug metabolism & toxicology 20060601 |
| A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. | Neurology 20060328 |
| Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. | Bioorganic & medicinal chemistry letters 20060315 |
| Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms. | Parasitology international 20060301 |
| Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor. | Acta crystallographica. Section D, Biological crystallography 20060301 |
| Dual binding mode of a novel series of DHODH inhibitors. | Journal of medicinal chemistry 20060223 |
| Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors. | Bioorganic & medicinal chemistry letters 20060115 |
| The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. | Bioorganic & medicinal chemistry letters 20060101 |
| A gold standard set of mechanistically diverse enzyme superfamilies. | Genome biology 20060101 |
| Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola. | Malaria journal 20060101 |
| Severe cytochrome c oxidase inhibition in vivo does not induce a pyrimidine deficiency; neuroprotective action of oral uridine prodrug PN401 requires supraphysiological levels of uridine. | Brain research 20051220 |
| Inhibitors designed for the active site of dihydroorotase. | Bioorganic chemistry 20051201 |
| The Systemic Theory of Living Systems. Part IV: Systemic Medicine--The Praxis. | Evidence-based complementary and alternative medicine : eCAM 20051201 |
| SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors. | Bioorganic & medicinal chemistry letters 20051101 |
| Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate. | Acta crystallographica. Section F, Structural biology and crystallization communications 20051001 |
| The systemic theory of living systems and relevance to CAM: the theory (Part III). | Evidence-based complementary and alternative medicine : eCAM 20050901 |
| Functional analysis of the pyrimidine de novo synthesis pathway in solanaceous species. | Plant physiology 20050801 |
| Regulation of the pyrimidine biosynthetic pathway in Pseudomonas mucidolens. | Antonie van Leeuwenhoek 20050801 |
| Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD. | The Journal of biological chemistry 20050708 |
| High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. | The Journal of biological chemistry 20050610 |
| Contribution of horizontal gene transfer to the evolution of Saccharomyces cerevisiae. | Eukaryotic cell 20050601 |
| Dihydroorotase from Escherichia coli: loop movement and cooperativity between subunits. | Journal of molecular biology 20050506 |
| The crystal structure of a novel, latent dihydroorotase from Aquifex aeolicus at 1.7A resolution. | Journal of molecular biology 20050506 |
| Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase. | Bioorganic & medicinal chemistry 20050315 |
| Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells. | Parasitology international 20050301 |
| Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778. | Antiviral research 20050101 |
| The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions. | Journal of molecular evolution 20050101 |
| The role of the T cell in autoimmune inflammation. | Arthritis research & therapy 20050101 |
| The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function. | Arthritis research & therapy 20050101 |
| Effect of carbon source on pyrimidine formation in Pseudomonas fluorescens ATCC 13525. | Microbiological research 20050101 |
| Mechanism of the dihydroorotase reaction. | Biochemistry 20041228 |
| Aquifex aeolicus dihydroorotase: association with aspartate transcarbamoylase switches on catalytic activity. | The Journal of biological chemistry 20041217 |
| Leflunomide inhibits transendothelial migration of peripheral blood mononuclear cells. | Annals of the rheumatic diseases 20041201 |
| Analysis of pyrimidine synthesis 'de novo' intermediates in urine and dried urine filter- paper strips with HPLC-electrospray tandem mass spectrometry. | Clinical chemistry 20041101 |
| The multiple roles of the mitochondrion of the malarial parasite. | Parasitology 20041101 |
| Severe impairment of nucleotide synthesis through inhibition of mitochondrial respiration. | Nucleosides, nucleotides & nucleic acids 20041001 |
| Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells. | Nucleosides, nucleotides & nucleic acids 20041001 |
| Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway. | The Journal of biological chemistry 20040806 |
| Protective and anti-arthritic effects of deer antler aqua-acupuncture (DAA), inhibiting dihydroorotate dehydrogenase, on phosphate ions-mediated chondrocyte apoptosis and rat collagen-induced arthritis. | International immunopharmacology 20040701 |
| Two different dihydroorotate dehydrogenases from yeast Saccharomyces kluyveri. | FEBS letters 20040618 |
| Multiple states of the Tyr318Leu mutant of dihydroorotate dehydrogenase revealed by single-molecule kinetics. | Journal of the American Chemical Society 20040609 |
| Thermodynamic basis of electron transfer in dihydroorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR spectroscopy, and ENDOR spectroscopy. | Biochemistry 20040601 |
| Horizontal gene transfer promoted evolution of the ability to propagate under anaerobic conditions in yeasts. | Molecular genetics and genomics : MGG 20040501 |
| Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. | Protein science : a publication of the Protein Society 20040401 |
| Leflunomide in the treatment of rheumatoid arthritis. | Clinical therapeutics 20040401 |
| Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement. | Bioorganic & medicinal chemistry letters 20040105 |
| In situ evidence of an alternative oxidase and an uncoupling protein in the respiratory chain of Aspergillus fumigatus. | The international journal of biochemistry & cell biology 20040101 |
| Regulation of pyrimidine nucleotide formation in Pseudomonas reptilivora. | Letters in applied microbiology 20040101 |
| The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes. | Arthritis research & therapy 20040101 |
| Regulation of pyrimidine nucleotide formation in Pseudomonas taetrolens ATCC 4683. | Microbiological research 20040101 |
| Antioxidant defense in Plasmodium falciparum--data mining of the transcriptome. | Malaria journal 20040101 |
| Gametocytogenesis: the puberty of Plasmodium falciparum. | Malaria journal 20040101 |
| The various sources of mitochondrial oxygen radicals: a minireview. | Toxicology mechanisms and methods 20040101 |
| Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model. | Transplantation 20031215 |
| Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: potential applications for restenosis and chronic rejection. | Transplantation 20030815 |
| Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function. | The Journal of biological chemistry 20030801 |
| Leflunomide for the treatment of rheumatoid arthritis. | Expert opinion on pharmacotherapy 20030601 |
| Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis. | Annals of the rheumatic diseases 20030401 |
| Cloning and expression of the dihydroorotate dehydrogenase from Toxoplasma gondii. | Biochimica et biophysica acta 20030320 |
| Synthesis of beta-hydroxy-propenamide derivatives and the inhibition of human dihydroorotate dehydrogenase. | Archives of pharmacal research 20030301 |
| Microarray analysis of orthologous genes: conservation of the translational machinery across species at the sequence and expression level. | Genome biology 20030101 |
| Dihydroorotate dehydrogenase of Escherichia coli. | Methods in molecular biology (Clifton, N.J.) 20030101 |
| Effect of carbon source on pyrimidine biosynthesis in Pseudomonas alcaligenes ATCC 14909. | Microbiological research 20030101 |
| Influence of carbon source on pyrimidine synthesis in Pseudomonas mendocina. | Journal of basic microbiology 20030101 |
| Molecular biology and biochemistry of malarial parasite pyrimidine biosynthetic pathway. | The Southeast Asian journal of tropical medicine and public health 20030101 |
| Dihydroorotase catalyzes the ring opening of the hydrolysis intermediates of the cardioprotective drug dexrazoxane (ICRF-187). | Drug metabolism and disposition: the biological fate of chemicals 20021201 |
| [Efficacy of leflunomide]. | Nihon rinsho. Japanese journal of clinical medicine 20021201 |
| Control of pyrimidine formation in Pseudomonas putida ATCC 17536. | Canadian journal of microbiology 20021201 |
| Mechanism of leflunomide-induced proliferation of mitochondria in mammalian cells. | Mitochondrion 20021201 |
| Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity. | The Journal of biological chemistry 20021101 |
| The dimeric dihydroorotate dehydrogenase A from Lactococcus lactis dissociates reversibly into inactive monomers. | Protein science : a publication of the Protein Society 20021101 |
| Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase. | Journal of medicinal chemistry 20021010 |
| Plant dihydroorotate dehydrogenase differs significantly in substrate specificity and inhibition from the animal enzymes. | FEBS letters 20021009 |
| Molecular analysis of de novo pyrimidine synthesis in solanaceous species. | Plant molecular biology 20021001 |
| Drosophila melanogaster dihydroorotate dehydrogenase: the N-terminus is important for biological function in vivo but not for catalytic properties in vitro. | Insect biochemistry and molecular biology 20020901 |
| E. coli dihydroorotate dehydrogenase reveals structural and functional distinctions between different classes of dihydroorotate dehydrogenases. | Structure (London, England : 1993) 20020901 |
| In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine. | Scandinavian journal of immunology 20020701 |
| Characterization of the dihydroorotate dehydrogenase as a soluble fumarate reductase in Trypanosoma cruzi. | Molecular and biochemical parasitology 20020701 |
| Detection and location of the enzymes of de novo pyrimidine biosynthesis in mammalian spermatozoa. | Reproduction (Cambridge, England) 20020601 |
| A new type of dihydroorotate dehydrogenase, type 1S, from the thermoacidophilic archaeon Sulfolobus solfataricus. | Extremophiles : life under extreme conditions 20020601 |
| [Leflunomide--a new drug for pharmacological immunomodulation]. | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20020501 |
| The interaction of 5-fluoroorotic acid with transition metals: synthesis and characterisation of Ni(II), Cu(II) and Zn(II) complexes. | Journal of inorganic biochemistry 20020428 |
| Leflunomide for the treatment of rheumatoid arthritis and autoimmunity. | The American journal of the medical sciences 20020401 |
| Enzymatic activities of Ura2 and Ura1 proteins (aspartate carbamoyltransferase and dihydro-orotate dehydrogenase) are present in both isolated membranes and cytoplasm of Saccharomyces cerevisiae. | Yeast (Chichester, England) 20020330 |
| Barbiturase, a novel zinc-containing amidohydrolase involved in oxidative pyrimidine metabolism. | The Journal of biological chemistry 20020301 |
| RNA interference (RNAi) inhibits growth of Plasmodium falciparum. | Molecular and biochemical parasitology 20020201 |
| Cloning, expression and preliminary X-ray analysis of the dihydroorotase from the hyperthermophilic eubacterium Aquifex aeolicus. | Acta crystallographica. Section D, Biological crystallography 20020101 |
| [The pyrimidine-biosynthetic (pyr) gene cluster in trypanosomes]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020101 |
| Regulation of pyrimidine synthesis in Pseudomonas mendocina. | Journal of basic microbiology 20020101 |
| Lateral gene transfer and parallel evolution in the history of glutathione biosynthesis genes. | Genome biology 20020101 |
| Characterisation and expression of a PP1 serine/threonine protein phosphatase (PfPP1) from the malaria parasite, Plasmodium falciparum: demonstration of its essential role using RNA interference. | Malaria journal 20020101 |
| Control of pyrimidine synthesis in Pseudomonas fragi. | Letters in applied microbiology 20020101 |
| Methodology and problems of protein-ligand docking: case study of dihydroorotate dehydrogenase, thymidine kinase, and phosphodiesterase 4. | Journal of receptor and signal transduction research 20020101 |
| Isolation of mitochondria from Plasmodium falciparum showing dihydroorotate dependent respiration. | Parasitology international 20011101 |
| Suppression of experimental autoimmune neuritis by leflunomide. | Brain : a journal of neurology 20010901 |
| Specific inhibition of a family 1A dihydroorotate dehydrogenase by benzoate pyrimidine analogues. | Journal of medicinal chemistry 20010830 |
| Dihydrooxonate is a substrate of dihydroorotate dehydrogenase (DHOD) providing evidence for involvement of cysteine and serine residues in base catalysis. | Archives of biochemistry and biophysics 20010715 |
| Contribution of the bacterial endosymbiont to the biosynthesis of pyrimidine nucleotides in the deep-sea tube worm Riftia pachyptila. | The Journal of biological chemistry 20010629 |
| Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center. | Biochemistry 20010619 |
| Insight into the chemistry of flavin reduction and oxidation in Escherichia coli dihydroorotate dehydrogenase obtained by rapid reaction studies. | Biochemistry 20010410 |
| Recombinant expression of N-terminal truncated mutants of the membrane bound mouse, rat and human flavoenzyme dihydroorotate dehydrogenase. A versatile tool to rate inhibitor effects? | European journal of biochemistry 20010301 |
| New disease modifying agents in adult rheumatoid arthritis. | Annals of the Academy of Medicine, Singapore 20010301 |
| Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase. | Biochemistry 20010220 |
| Anti-arthritic effects of KF20444, a new immunosuppressive compound inhibiting dihydroorotate dehydrogenase, on rat collagen-induced arthritis. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010101 |
| The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology. | IUBMB life 20010101 |
| Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives. | Biochemical pharmacology 19981101 |
| Structural and functional comparison of agents interfering with dihydroorotate, succinate and NADH oxidation of rat liver mitochondria. | Biochemical pharmacology 19981015 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.