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154-93-8

154-93-8 | 1,3-Bis(2-chloroethyl)nitrosourea

CAS No: 154-93-8 Catalog No: AG003DHD MDL No:MFCD00057706

Product Description

Catalog Number:
AG003DHD
Chemical Name:
1,3-Bis(2-chloroethyl)nitrosourea
CAS Number:
154-93-8
Molecular Formula:
C5H9Cl2N3O2
Molecular Weight:
214.0499
MDL Number:
MFCD00057706
IUPAC Name:
1,3-bis(2-chloroethyl)-1-nitrosourea
InChI:
InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
InChI Key:
DLGOEMSEDOSKAD-UHFFFAOYSA-N
SMILES:
ClCCNC(=O)N(CCCl)N=O
EC Number:
205-838-2
UNII:
U68WG3173Y
UN Number:
2811

Properties

Complexity:
156  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
213.007g/mol
Formal Charge:
0
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
214.046g/mol
Monoisotopic Mass:
213.007g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
61.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.5  

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Early toxicity predicts long-term survival in high-grade glioma. British journal of cancer 20110426
Candida parapsilosis meningitis associated with Gliadel (BCNU) wafer implants. British journal of neurosurgery 20110401
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Imaging in real-time with FRET the redox response of tumorigenic cells to glutathione perturbations in a microscale flow. Integrative biology : quantitative biosciences from nano to macro 20110301
Occlusion of surgical opening of the ventricular system with fibrinogen-coated collagen fleece: a case collection study. Acta neurochirurgica 20110301
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Controversies in the adjuvant therapy of high-grade gliomas. The oncologist 20110301
The effect of cytostatics and hyperthermia on RAJI human lymphoma cells. Experimental oncology 20110301
Safety and feasibility of the adjunct of local chemotherapy with biodegradable carmustine (BCNU) wafers to the standard multimodal approach to high grade gliomas at first diagnosis. Journal of neurosurgical sciences 20110301
Depressogenic effects of medications: a review. Dialogues in clinical neuroscience 20110301
Development of cortical malformations in BCNU-treated rat, model of cortical dysplasia. Neuroscience 20110223
Autologous peripheral blood stem cell transplantation in children with refractory or relapsed lymphoma: results of Children's Oncology Group study A5962. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20110201
BEAM or BuCyE high-dose chemotherapy followed by autologous stem cell transplantation in non-Hodgkin's lymphoma patients: a single center comparative analysis of efficacy and toxicity. Leukemia research 20110201
Effect of protein S-glutathionylation on Ca2+ homeostasis in cultured aortic endothelial cells. American journal of physiology. Heart and circulatory physiology 20110201
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Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response. Radiation oncology (London, England) 20110101
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(-)Schisandrin B ameliorates paraquat-induced oxidative stress by suppressing glutathione depletion and enhancing glutathione recovery in differentiated PC12 cells. BioFactors (Oxford, England) 20110101
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Battling Chemotherapy-induced Nausea and Vomiting in Cancer Palliative Care. Indian journal of palliative care 20110101
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Diffusion MR Imaging of the Brain in Patients with Cancer. International journal of molecular imaging 20110101
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Consensus conference on the use of 90-yttrium-ibritumomab tiuxetan therapy in clinical practice. A project of the Italian society of hematology. American journal of hematology 20100201
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Elevated expression of Dickkopf-1 increases the sensitivity of human glioma cell line SHG44 to BCNU. Journal of experimental & clinical cancer research : CR 20100101
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Development of a Novel Fluorescence Assay Based on the Use of the Thrombin-Binding Aptamer for the Detection of O-Alkylguanine-DNA Alkyltransferase Activity. Journal of nucleic acids 20100101
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Modification of composition of a nanoemulsion with different cholesteryl ester molecular species: effects on stability, peroxidation, and cell uptake. International journal of nanomedicine 20100101
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Two phase II trials of temozolomide with interferon-alpha2b (pegylated and non-pegylated) in patients with recurrent glioblastoma multiforme. British journal of cancer 20090818
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Association of preoperative depression and survival after resection of malignant brain astrocytoma. Surgical neurology 20090301
Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme. Journal of neurosurgery 20090301
Glial cell-line derived neurotrophic factor (GDNF) family of ligands confer chemoresistance in a ligand-specific fashion in malignant gliomas. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090301
Monitoring of tumor response to chemotherapy in vivo by a novel small-molecule detector of apoptosis. Apoptosis : an international journal on programmed cell death 20090301
Mass selection of ions from beams using waveform isolation in radiofrequency quadrupoles. Analytical chemistry 20090301
Reduced-intensity conditioning regimen workshop: defining the dose spectrum. Report of a workshop convened by the center for international blood and marrow transplant research. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20090301
Incidence and risk factors for second cancers after autologous hematopoietic cell transplantation for aggressive non-Hodgkin lymphoma. Leukemia & lymphoma 20090301
Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells. Biochemical and biophysical research communications 20090206
Experience with irinotecan for the treatment of malignant glioma. Neuro-oncology 20090201
DNA alkylation products formed by 1-(2-chloroethyl)-1-nitrosourea as molecular dosimeters of therapeutic response. Journal of neuro-oncology 20090201
High-dose Ara-C and beam with autograft rescue in R-CHOP responsive mantle cell lymphoma patients. British journal of haematology 20090201
Pseudo-bowel obstruction due to varicella zoster virus infection after autologous stem cell transplantation. American journal of hematology 20090201
Growth inhibition against intracranial C6 glioma cells by stereotactic delivery of BCNU by controlled release from poly(D,L-lactic acid) nanoparticles. Technology in cancer research & treatment 20090201
Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme. Clinical cancer research : an official journal of the American Association for Cancer Research 20090201
Favorable outcome of primary CNS anaplastic large cell lymphoma in an immunocompetent patient. Journal of pediatric hematology/oncology 20090201
[Interdigitating dendritic cell sarcoma of lower extremities resistant to high dose chemotherapy BEAM with peripheral blood stem cell transplantation]. Vnitrni lekarstvi 20090201
Characterization of a novel dithiocarbamate glutathione reductase inhibitor and its use as a tool to modulate intracellular glutathione. The Journal of biological chemistry 20090130
Metallothionein attenuates carmustine-induced oxidative stress and protects against pulmonary fibrosis in rats. Archives of toxicology 20090101
The Prospective Oral Mucositis Audit: relationship of severe oral mucositis with clinical and medical resource use outcomes in patients receiving high-dose melphalan or BEAM-conditioning chemotherapy and autologous SCT. Bone marrow transplantation 20090101
Increased risk for invasive aspergillosis in patients with lymphoproliferative diseases after autologous hematopoietic SCT. Bone marrow transplantation 20090101
Comparative analysis of temozolomide (TMZ) versus 1,3-bis (2-chloroethyl)-1 nitrosourea (BCNU) in newly diagnosed glioblastoma multiforme (GBM) patients. Journal of neuro-oncology 20090101
What is the translational efficacy of chemotherapeutic drug research in neuro-oncology? A systematic review and meta-analysis of the efficacy of BCNU and CCNU in animal models of glioma. Journal of neuro-oncology 20090101
Independent association of extent of resection with survival in patients with malignant brain astrocytoma. Journal of neurosurgery 20090101
Autologous stem-cell transplantation as first-line therapy in peripheral T-cell lymphomas: results of a prospective multicenter study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090101
Suppression of HLA expression by lentivirus-mediated gene transfer of siRNA cassettes and in vivo chemoselection to enhance hematopoietic stem cell transplantation. Immunologic research 20090101
[Diagnostic and treatment delays do not modify the treatment outcome of patients with multiform glioblastoma]. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20090101
Drugs targeting the mitochondrial pore act as cytotoxic and cytostatic agents in temozolomide-resistant glioma cells. Journal of translational medicine 20090101
Localized BCNU chemotherapy and the multimodal management of malignant glioma. Current medical research and opinion 20090101
Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. PloS one 20090101
Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors. PloS one 20090101
Long term survivors with metastatic pancreatic adenocarcinoma treated with gemcitabine: a retrospective analysis. Journal of hematology & oncology 20090101
Stereotactic radiosurgery for glioblastoma: retrospective analysis. Radiation oncology (London, England) 20090101
Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation. BMC cancer 20090101
Delta-ALA-D activity is a reliable marker for oxidative stress in bone marrow transplant patients. BMC cancer 20090101
Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PloS one 20090101
Primary non-Hodgkin's lymphoma of the infratemporal fossa: a rare case report. Head & neck oncology 20090101
Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma. BMC cancer 20090101
Current available therapies and future directions in the treatment of malignant gliomas. Biologics : targets & therapy 20090101
Transcriptome and proteome analyses of adaptive responses to methyl methanesulfonate in Escherichia coli K-12 and ada mutant strains. BMC microbiology 20090101
Drugs associated with more suicidal ideations are also associated with more suicide attempts. PloS one 20090101
Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study. PloS one 20090101
A dosimetric comparison of four treatment planning methods for high grade glioma. Radiation oncology (London, England) 20090101
Integrated-boost IMRT or 3-D-CRT using FET-PET based auto-contoured target volume delineation for glioblastoma multiforme--a dosimetric comparison. Radiation oncology (London, England) 20090101
Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles. PloS one 20090101
Standard therapy of advanced Hodgkin lymphoma. Hematology. American Society of Hematology. Education Program 20090101
Introduction of hypermatrix and operator notation into a discrete mathematics simulation model of malignant tumour response to therapeutic schemes in vivo. Some operator properties. Cancer informatics 20090101
Recursive partitioning analysis of prognostic factors in WHO grade III glioma patients treated with radiotherapy or radiotherapy plus chemotherapy. BMC cancer 20090101
Marking the onset of oxidative stress: biomarkers and novel strategies. Oxidative medicine and cellular longevity 20090101
Metallothionein induction reduces caspase-3 activity and TNFalpha levels with preservation of cognitive function and intact hippocampal neurons in carmustine-treated rats. Oxidative medicine and cellular longevity 20090101
Promising treatments of tomorrow for multiple sclerosis. Annals of Indian Academy of Neurology 20090101
Specific factors influence the success of autologous and allogeneic hematopoietic stem cell transplantation. Oxidative medicine and cellular longevity 20090101
Synergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy. International journal of general medicine 20090101
Role of bendamustine in the treatment of chronic lymphocytic leukemia. OncoTargets and therapy 20090101
Targeted therapy in the treatment of malignant gliomas. OncoTargets and therapy 20090101
Update on the rational use of Y-ibritumomab tiuxetan in the treatment of follicular lymphoma. OncoTargets and therapy 20090101
Update on the rational use of tositumomab and iodine-131 tositumomab radioimmunotherapy for the treatment of non-Hodgkin's lymphoma. OncoTargets and therapy 20090101
Bendamustine in the treatment of non-Hodgkin's lymphomas. OncoTargets and therapy 20090101
Temozolomide: The evidence for its therapeutic efficacy in malignant astrocytomas. Core evidence 20090101
New therapies for recurrent glioblastomas. F1000 medicine reports 20090101
Integrated care and optimal management of pulmonary arterial hypertension. Journal of multidisciplinary healthcare 20090101
Gene therapy in thalassemia and hemoglobinopathies. Mediterranean journal of hematology and infectious diseases 20090101
Early versus late intensification for patients with high-risk Hodgkin lymphoma-3 cycles of intensive chemotherapy plus low-dose lymph node radiation therapy versus 4 cycles of combined doxorubicin, bleomycin, vinblastine, and dacarbazine plus myeloablative chemotherapy with autologous stem cell transplantation: five-year results of a randomized trial on behalf of the GOELAMS Group. Cancer 20081215
Influence of pre- and post-transplantation responses on outcome of patients with multiple myeloma: sequential improvement of response and achievement of complete response are associated with longer survival. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20081210
Three weeks release BCNU loaded hydrophilic-PLGA microspheres for interstitial chemotherapy: Development and activity against human glioblastoma cells. Journal of microencapsulation 20081201
Phase I analysis of BCNU-impregnated biodegradable polymer wafers followed by systemic interferon alfa-2b in adults with recurrent glioblastoma multiforme. Journal of neuro-oncology 20081201
Development of an O(6)-alkylguanine-DNA alkyltransferase assay based on covalent transfer of the benzyl moiety from [benzene-3H]O(6)-benzylguanine to the protein. Analytical biochemistry 20081201
Myeloablative chemotherapy with autologous bone marrow rescue in children and adolescents with recurrent malignant astrocytoma: outcome compared with conventional chemotherapy: a report from the Children's Oncology Group. Pediatric blood & cancer 20081201
Autologous stem cell transplantation for diffuse large B-cell lymphoma with residual extranodal involvement. The Korean journal of internal medicine 20081201
Prospective trial of gross-total resection with Gliadel wafers followed by early postoperative Gamma Knife radiosurgery and conformal fractionated radiotherapy as the initial treatment for patients with radiographically suspected, newly diagnosed glioblastoma multiforme. Journal of neurosurgery 20081201
Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation. Blood 20081115
Going with the flow, and beyond, in myeloma. Blood 20081115
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry 20081113
Pretransplantation positron emission tomography scan is the main predictor of autologous stem cell transplantation outcome in aggressive B-cell non-Hodgkin lymphoma. Cancer 20081101
Safety profile of carmustine wafers in malignant glioma: a review of controlled trials and a decade of clinical experience. Current medical research and opinion 20081101
Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience. Annals of surgical oncology 20081001
Myelomatous meningitis. European journal of haematology 20081001
Effect of the dose per body weight of conditioning chemotherapy on severity of mucositis and risk of relapse after autologous haematopoietic stem cell transplantation in relapsed diffuse large B cell lymphoma. British journal of haematology 20081001
Effects, in an in-vivo model system, of 1,2,3,4-tetrahydroisoquinoline on glioma. Anti-cancer drugs 20081001
High-dose chemotherapy with BEAM or Busulphan/Melphalan and Thiotepa followed by hematopoietic cell transplantation in malignant lymphoma. Leukemia & lymphoma 20081001
Intrathecal corticosteroids might slow Alzheimer's disease progression. Neuropsychiatric disease and treatment 20081001
Pharmacologic blockade of chloride channel synergistically enhances apoptosis of chemotherapeutic drug-resistant cancer stem cells. Biochemical and biophysical research communications 20080905
Late-onset neutropenia following viral bone marrow depression after rituximab therapy. Annals of hematology 20080901
Assessment of a balloon-tipped catheter modified for intracerebral convection-enhanced delivery. Journal of neuro-oncology 20080901
Relationship of glioblastoma multiforme to the lateral ventricles predicts survival following tumor resection. Journal of neuro-oncology 20080901
Keratinocyte growth factor is effective in the prevention of intestinal mucositis in patients with hematological malignancies treated with high-dose chemotherapy and autologous hematopoietic SCT: a video-capsule endoscopy study. Bone marrow transplantation 20080901
[Clinical outcome 6 years after autologous hematopoietic stem cell transplantation in multiple sclerosis]. Neurologia (Barcelona, Spain) 20080901
[A case of interstitial pneumonia caused by carmustine.]. Zhongguo fei ai za zhi = Chinese journal of lung cancer 20080820
Tumour-targeted nanomedicines: principles and practice. British journal of cancer 20080805
Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. Molecular pharmacology 20080801
External beam irradiation and the combination of cisplatin and carmustine followed by carmustine alone for the treatment of high-grade glioma: a phase 2 Southwest Oncology Group trial. Cancer 20080801
Polyanhydrides as localized drug delivery carrier: an update. Expert opinion on drug delivery 20080801
Bendamustine HCL for the treatment of relapsed indolent non-Hodgkin's lymphoma. Therapeutics and clinical risk management 20080801
Chemotherapeutic wafers for High Grade Glioma. The Cochrane database of systematic reviews 20080716
Reduced-toxicity conditioning with fludarabine, BCNU, and melphalan in allogeneic hematopoietic cell transplantation: particular activity against advanced hematologic malignancies. Blood 20080715
Noninvasive assessment of E2F-1-mediated transcriptional regulation in vivo. Cancer research 20080715
Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer: results of secondary end points analyses. British journal of cancer 20080708
Long-term outcome of autologous stem-cell transplantation in relapsed or refractory Hodgkin's lymphoma. Annals of oncology : official journal of the European Society for Medical Oncology 20080701
A retrospective study of the safety of BCNU wafers with concurrent temozolomide and radiotherapy and adjuvant temozolomide for newly diagnosed glioblastoma patients. Journal of neuro-oncology 20080701
Carmustine-resistant cancer cells are sensitized to temozolomide as a result of enhanced mismatch repair during the development of carmustine resistance. Molecular pharmacology 20080701
Comorbidities, not age, impact outcomes in autologous stem cell transplant for relapsed non-Hodgkin lymphoma. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20080701
Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase. Cancer investigation 20080701
Skin directed therapy for mycosis fungoides: a review. Journal of drugs in dermatology : JDD 20080701
Prognostic molecular markers with no impact on decision-making: the paradox of gliomas based on a prospective study. British journal of cancer 20080603
A possible role for intracellular GSH in spontaneous reaction of a cysteine (T338C) engineered into the Cystic Fibrosis Transmembrane Conductance Regulator. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20080601
Chylous ascites secondary to B-cell non Hodgkin's lymphoma in a patient with the acquired immune deficiency syndrome (AIDS). Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20080601
Adjuvant dibromodulcitol and BCNU chemotherapy in anaplastic astrocytoma: results of a randomised European Organisation for Research and Treatment of Cancer phase III study (EORTC study 26882). European journal of cancer (Oxford, England : 1990) 20080601
Oxidoreductase regulation of Kv currents in rat ventricle. Journal of molecular and cellular cardiology 20080601
[Chemotherapy and renal toxicity]. Bulletin du cancer 20080528
A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer. British journal of cancer 20080520
Altered spatial distribution of PV-cortical cells and dysmorphic neurons in the somatosensory cortex of BCNU-treated rat model of cortical dysplasia. Epilepsia 20080501
Peripheral blood stem cell transplant for POEMS syndrome is associated with high rates of engraftment syndrome. European journal of haematology 20080501
Controlled-release implant system formulated using biodegradable hemostatic gauze as scaffold. International journal of pharmaceutics 20080501
Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients. Journal of neuro-oncology 20080501
Intensive chemotherapy (high-dose CHOP/ESHAP regimen) followed by autologous stem-cell transplantation in previously untreated patients with peripheral T-cell lymphoma. Annals of oncology : official journal of the European Society for Medical Oncology 20080501
Intracavitary chemotherapy (Gliadel) and oral low-dose etoposide for recurrent anaplastic ependymoma. Oncology reports 20080501
High-dose chemotherapy with autologous stem cell transplantation in adults with recurrent embryonal tumors of the central nervous system. Cancer 20080415
Intensive conditioning regimen of etoposide (VP-16), cyclophosphamide and carmustine (VCB) followed by autologous hematopoietic stem cell transplantation for relapsed and refractory Hodgkin's lymphoma. Bone marrow transplantation 20080401
Theaflavin-3,3'-digallate, a component of black tea: an inducer of oxidative stress and apoptosis. Toxicology in vitro : an international journal published in association with BIBRA 20080401
Outcome of BEAM-autologous and BEAM-alemtuzumab allogeneic transplantation in relapsed advanced stage follicular lymphoma. British journal of haematology 20080401
Prospective oral mucositis audit: oral mucositis in patients receiving high-dose melphalan or BEAM conditioning chemotherapy--European Blood and Marrow Transplantation Mucositis Advisory Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080320
Successful treatment of a child with late-onset T-cell post-transplant lymphoproliferative disorder/lymphoma. Pediatric blood & cancer 20080301
Time-dependent effect of non-Hodgkin's lymphoma grade on disease-free survival of relapsed/refractory patients treated with high-dose chemotherapy plus autotransplantation. Contemporary clinical trials 20080301
Phase 1 trial of O6-benzylguanine and BCNU in children with CNS tumors: a Children's Oncology Group study. Pediatric blood & cancer 20080301
Dose-escalated CHOP and tailored intensification with IFE according to early response and followed by BEAM/autologous stem-cell transplantation in poor-risk aggressive B-cell lymphoma: a prospective study from the GEL-TAMO Study Group. European journal of haematology 20080301
Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth. Free radical biology & medicine 20080301
Bone marrow-derived cells exhibiting lung epithelial cell characteristics are enriched in vivo using methylguanine DNA methyltransferase-mediated drug resistance. Stem cells (Dayton, Ohio) 20080301
Synthesis and characterization of DNA containing an N1-2'-deoxyinosine-ethyl-N3-thymidine interstrand cross-link: a structural mimic of the cross-link formed by 1,3-bis-(2-chloroethyl)-1-nitrosourea. Chemical research in toxicology 20080301
A phase 2 pilot study of pegfilgrastim and filgrastim for mobilizing peripheral blood progenitor cells in patients with non-Hodgkin's lymphoma receiving chemotherapy. Haematologica 20080301
Transient global amnesia associated with the infusion of DMSO-cryopreserved autologous peripheral blood stem cells. Haematologica 20080301
Carmustine wafers: localized delivery of chemotherapeutic agents in CNS malignancies. Expert review of anticancer therapy 20080301
Clinical uses of GM-CSF, a critical appraisal and update. Biologics : targets & therapy 20080301
A safety and efficacy study of local delivery of interleukin-12 transgene by PPC polymer in a model of experimental glioma. Anti-cancer drugs 20080201
Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment. European journal of clinical pharmacology 20080201
Safety and efficacy of permanent iodine-125 seed implants and carmustine wafers in patients with recurrent glioblastoma multiforme. Journal of neurosurgery 20080201
[Chemosensitivity test on brain tumors]. Neurocirugia (Asturias, Spain) 20080201
Epigenetic silencing of telomerase and a non-alkylating agent as a novel therapeutic approach for glioma. Brain research 20080110
High-dose therapy and autologous stem-cell transplantation in angioimmunoblastic lymphoma: complete remission at transplantation is the major determinant of Outcome-Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080110
Preferential migration of regulatory T cells mediated by glioma-secreted chemokines can be blocked with chemotherapy. Cancer immunology, immunotherapy : CII 20080101
Transient cerebral hypoperfusion enhances intraarterial carmustine deposition into brain tissue. Journal of neuro-oncology 20080101
BEAC or BEAM high-dose chemotherapy followed by autologous stem cell transplantation in non-Hodgkin's lymphoma patients: comparative analysis of efficacy and toxicity. Annals of hematology 20080101
Phase II trial of a transplantation regimen of yttrium-90 ibritumomab tiuxetan and high-dose chemotherapy in patients with non-Hodgkin's lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080101
Carmustine implants for the treatment of newly diagnosed high-grade gliomas: a cost-utility analysis. PharmacoEconomics 20080101
Cannabinoids as potential new therapy for the treatment of gliomas. Expert review of neurotherapeutics 20080101
Prospective single-arm study of 72 Gy hyperfractionated radiation therapy and combination chemotherapy for anaplastic astrocytomas. BMC cancer 20080101
Cutaneous lymphoma. Current problems in cancer 20080101
BCNU toxicity presenting with a large pericardial and pleural effusion. Annals of transplantation 20080101
Idiopathic pulmonary fibrosis. Orphanet journal of rare diseases 20080101
Systematic review of the clinical effect of glucocorticoids on nonhematologic malignancy. BMC cancer 20080101
Chemotherapy-induced bystander effect in response to several chloroethylnitrosoureas: an origin independent of DNA damage? Anticancer research 20080101
How chemotherapy damages the central nervous system. Journal of biology 20080101
Proline-linked nitrosoureas as prolidase-convertible prodrugs in human breast cancer cells. Pharmacological reports : PR 20080101
Bcl-2 expression is not associated with survival in metastatic cutaneous melanoma: a historical cohort study. World journal of surgical oncology 20080101
Over-expression of Skp2 is associated with resistance to preoperative doxorubicin-based chemotherapy in primary breast cancer. Breast cancer research : BCR 20080101
Cytotoxic and apoptotic effects of bortezomib and gefitinib compared to alkylating agents on human glioblastoma cells. Journal of experimental therapeutics & oncology 20080101
[Postoperative chemoradiotherapy for cerebral glioblastoma]. Voprosy onkologii 20080101
The prince and the pauper. A tale of anticancer targeted agents. Molecular cancer 20080101
Antitumor effects of desmopressin in combination with chemotherapeutic agents in a mouse model of breast cancer. Anticancer research 20080101
[Clinical features and combined treatment of the central nervous system in Hodgkin's disease]. Voprosy onkologii 20080101
Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells. Journal of translational medicine 20080101
[(18)F]Fluoroethyltyrosine- positron emission tomography-guided radiotherapy for high-grade glioma. Radiation oncology (London, England) 20080101
Crossing borders: surgically mediated drug delivery techniques. Clinical neurosurgery 20080101
Reinduction of bevacizumab in combination with pegylated liposomal Doxorubicin in a patient with recurrent glioblastoma multiforme who progressed on bevacizumab/irinotecan. Journal of oncology 20080101
[Evaluation of selected endocrine complications in patients treated with auto- and allo-haematopoietic stem cell transplantation]. Medycyna wieku rozwojowego 20080101
Strategies for enhanced drug delivery to the central nervous system. Indian journal of pharmaceutical sciences 20080101
A Single Institution's Experience with Bevacizumab in Combination with Cytotoxic Chemotherapy in Progressive Malignant Glioma. Clinical medicine. Oncology 20080101
Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks. Cancer research 20071215
Refractory multiple myeloma treated with homoharringtonine: report of two cases. Annals of hematology 20071201
Generation and functional characterization of mice with a disrupted glutathione S-transferase, theta 1 gene. Drug metabolism and disposition: the biological fate of chemicals 20071201
Phenol-induced in vivo oxidative stress in skin: evidence for enhanced free radical generation, thiol oxidation, and antioxidant depletion. Chemical research in toxicology 20071201
Management of glioblastoma. Expert opinion on pharmacotherapy 20071201
[Chlormethine (Caryolysine), carmustine (Bicnu)]. Annales de dermatologie et de venereologie 20071201
Management of patients with newly diagnosed malignant primary brain tumors with a focus on the evolving role of temozolomide. Therapeutics and clinical risk management 20071201
Cisplatin, gemcitabine, and treosulfan in relapsed stage IV cutaneous malignant melanoma patients. British journal of cancer 20071119
Tamoxifen accelerates proteasomal degradation of O6-methylguanine DNA methyltransferase in human cancer cells. International journal of cancer 20071115
Resorbable polymer microchips releasing BCNU inhibit tumor growth in the rat 9L flank model. Journal of controlled release : official journal of the Controlled Release Society 20071106
Outcome of children treated with preradiation chemotherapy for a high-grade glioma: results of a French Society of Pediatric Oncology (SFOP) Pilot Study. Pediatric blood & cancer 20071101
Frequency, severity and risk factors for oral mucositis after BEAM conditioning and autologous peripheral blood stem cell transplantation: a single center analysis and review of the literature. Leukemia & lymphoma 20071101
The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluation. Health technology assessment (Winchester, England) 20071101
Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine. Journal of medicinal chemistry 20071018
Primary refractory Hodgkin's lymphoma: outcome after high-dose chemotherapy and autologous SCT and impact of various prognostic factors on overall and event-free survival. A single institution result of 66 patients. Bone marrow transplantation 20071001
Uptake and reduction of alpha-lipoic acid by human erythrocytes. Clinical biochemistry 20071001
Transplantation tolerance: lessons from experimental rodent models. Transplant international : official journal of the European Society for Organ Transplantation 20071001
Ultrasound-enhanced chemotherapy and gene delivery for glioma cells. Technology in cancer research & treatment 20071001
Gliadel wafers in the treatment of malignant glioma: a systematic review. Current oncology (Toronto, Ont.) 20071001
Autologous stem cell transplantation for chronic lymphocytic leukemia. Seminars in hematology 20071001
Tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma. Stem cells and development 20071001
Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas. Therapeutics and clinical risk management 20071001
Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression. Blood 20070915
[What type of adjuvant chemotherapy should be proposed for the initial treatment of glioblastoma?]. Presse medicale (Paris, France : 1983) 20070901
Zebrafish as a model system to screen radiation modifiers. Current genomics 20070901
Diagnosis and management of primary intraocular lymphoma: an update. Clinical ophthalmology (Auckland, N.Z.) 20070901
O6-benzylguanine and BCNU in multiple myeloma: a phase II trial. Cancer chemotherapy and pharmacology 20070801
Spontaneous pregnancy and normal delivery after repeated autologous bone marrow transplantation and GnRH agonist treatment. Human reproduction (Oxford, England) 20070801
Selective cell death of oncogenic Akt-transduced brain cancer cells by etoposide through reactive oxygen species mediated damage. Molecular cancer therapeutics 20070801
[Complete remission of relapsed mixed cellularity Hodgkin's disease treated with rituximab]. Deutsche medizinische Wochenschrift (1946) 20070801
Mycosis fungoides. Dermatology nursing 20070801
The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications. Current genomics 20070801
Neuroprotective effects of melatonin upon the offspring cerebellar cortex in the rat model of BCNU-induced cortical dysplasia. Brain research 20070730
Hypoxic remodelling of Ca2+signalling in SH-SY5Y cells: influence of glutathione. Neuroreport 20070702
The interaction of chromium (VI) with macrophages: depletion of glutathione and inhibition of glutathione reductase. Toxicology 20070701
New chemotherapy options for the treatment of malignant gliomas. Anti-cancer drugs 20070701
Treatment of single brain metastasis with resection, intracavity carmustine polymer wafers, and radiation therapy is safe and provides excellent local control. Clinical cancer research : an official journal of the American Association for Cancer Research 20070615
Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutation research 20070601
Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner. Arteriosclerosis, thrombosis, and vascular biology 20070601
Canadian recommendations for the treatment of glioblastoma multiforme. Current oncology (Toronto, Ont.) 20070601
Microphthalmos associated with Dartmouth combination chemotherapy in pregnancy: a case report. The Journal of reproductive medicine 20070601
Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors. Therapeutics and clinical risk management 20070601
An overview of the clinical use of ondansetron in preschool age children. Therapeutics and clinical risk management 20070601
[Changes of expression of cation-chloride cotransporter genes in hippocampus of cortical dysplasia: experiment with rat]. Zhonghua yi xue za zhi 20070522
Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice. Carcinogenesis 20070501
Single nucleotide polymorphisms and expression of ERCC1 and ERCC2 vis-à-vis chemotherapy drug cytotoxicity in human glioma. Journal of neuro-oncology 20070501
Interstitial chemotherapy for malignant gliomas: the Johns Hopkins experience. Journal of neuro-oncology 20070501
The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents. Journal of molecular medicine (Berlin, Germany) 20070501
A second autologous transplant may be efficacious in selected patients with Hodgkin's lymphoma relapsing after a previous autograft. Leukemia & lymphoma 20070501
Long-term outcomes after reduced-intensity conditioning allogeneic stem cell transplantation for low-grade lymphoma: a survey by the French Society of Bone Marrow Graft Transplantation and Cellular Therapy (SFGM-TC). Haematologica 20070501
Adjuvant therapy in glioblastomas: false steps and real advances. Expert review of anticancer therapy 20070501
In vivo selection and chemoprotection after drug resistance gene therapy in a nonmyeloablative allogeneic transplantation setting in dogs. Human gene therapy 20070501
Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene 20070419
The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. Journal of the National Cancer Institute 20070418
Does high-dose carmustine increase overall survival in supratentorial high-grade malignant glioma? An EBMT retrospective study. International journal of cancer 20070415
Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes. Free radical biology & medicine 20070415
Autologous peripheral blood stem cell transplantation in multiple myeloma using oral versus I.V. melphalan. Annals of hematology 20070401
Efficacy and tolerability of currently available therapies for the mycosis fungoides and Sezary syndrome variants of cutaneous T-cell lymphoma. Cancer treatment reviews 20070401
Yttrium-90-ibritumomab tiuxetan (Zevalin) combined with high-dose BEAM chemotherapy and autologous stem cell transplantation for chemo-refractory aggressive non-Hodgkin's lymphoma. Experimental hematology 20070401
Cellular and functional characterization of immunoresistant human glioma cell clones selected with alloreactive cytotoxic T lymphocytes reveals their up-regulated synthesis of biologically active TGF-beta. Journal of immunotherapy (Hagerstown, Md. : 1997) 20070401
[Transdermal fentanyl in treating severe painful mucositis caused by autologous hematopoietic stem cell transplantation]. Ai zheng = Aizheng = Chinese journal of cancer 20070401
Dynamics of chemosensitivity and chromosomal instability in recurrent glioblastoma. British journal of cancer 20070326
Monitoring the effects of BCNU chemotherapy Wafers (Gliadel) in glioblastoma multiforme with proton magnetic resonance spectroscopic imaging at 3.0 Tesla. Journal of neuro-oncology 20070301
Higher glioblastoma tumour burden reduces efficacy of chemotherapeutic agents: in vitro evidence. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20070301
Fatal outcome related to carmustine implants in glioblastoma multiforme. Acta neurochirurgica 20070301
Autologous stem cell transplantation after complete remission and first consolidation in acute myeloid leukemia patients aged 61-70 years: results of the prospective EORTC-GIMEMA AML-13 study. Haematologica 20070301
Palifermin and palmar-plantar erythrodysesthesia. British journal of haematology 20070301
High-dose chemotherapy using BEAM without autologous rescue followed by reduced-intensity conditioning allogeneic stem-cell transplantation for refractory or relapsing lymphomas: a comparison of delayed versus immediate transplantation. Bone marrow transplantation 20070301
Tandem high-dose chemotherapy and autologous stem cell transplantation in refractory/relapsed Hodgkin's lymphoma: a monocenter prospective study. American journal of hematology 20070201
Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070201
Fatal leukoencephalopathy after reduced-intensity allogeneic stem cell transplantation. Onkologie 20070201
Imaging response in malignant glioma, RTOG 90-06. American journal of clinical oncology 20070201
In vivo imaging in a murine model of glioblastoma. Neurosurgery 20070201
Factors influencing engraftment in autologous peripheral hematopoetic stem cell transplantation (PBSCT). Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 20070201
Dexa-BEAM as salvage therapy in patients with primary refractory aggressive non-Hodgkin lymphoma. Leukemia & lymphoma 20070201
Dang-Gui Buxue Tang protects against oxidant injury by enhancing cellular glutathione in H9c2 cells: role of glutathione synthesis and regeneration. Planta medica 20070201
Small cell carcinoma of the nasopharynx. Acta oto-laryngologica 20070201
[What is your diagnosis? Neutropenic colitis (neutropenic typhlitis)]. Praxis 20070124
Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB. Proceedings of the National Academy of Sciences of the United States of America 20070116
A phase I/II study of lomustine and temozolomide in patients with cerebral metastases from malignant melanoma. British journal of cancer 20070115
Levels and distribution of BCNU in GBM tumors following intratumoral injection of DTI-015 (BCNU-ethanol). Neuro-oncology 20070101
Initial chemotherapy with mitoxantrone, chlorambucil, prednisone impairs the collection of stem cells in patients with indolent lymphomas--results of a randomized comparison by the German Low-Grade Lymphoma Study Group. Annals of oncology : official journal of the European Society for Medical Oncology 20070101
Combination chemotherapy followed by autologous stem cell transplant for enteropathy-associated T cell lymphoma. British journal of haematology 20070101
Enantioselectivity of thalidomide serum and tissue concentrations in a rat glioma model and effects of combination treatment with cisplatin and BCNU. The Journal of pharmacy and pharmacology 20070101
A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents. Molecular cancer research : MCR 20070101
High-dose therapy and autologous stem cell transplantation for Hodgkin's lymphoma in relapse or failure after initial chemotherapy : results of the Centre National de Greffe de Moelle Osseuse de Tunis. La Tunisie medicale 20070101
Fibrillary glomerulonephritis with small fibrils in a patient with the antiphospholipid antibody syndrome successfully treated with immunosuppressive therapy. BMC nephrology 20070101
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[Visual cortes--is it a concern?]. Bulletin de la Societe belge d'ophtalmologie 20070101
Radiotherapeutic alternatives for previously irradiated recurrent gliomas. BMC cancer 20070101
Spontaneous immune responses against glioma-associated antigens in a long term survivor with malignant glioma. Journal of translational medicine 20070101
Valproic acid increases the in vitro effects of nitrosureas on human glioma cell lines. Oncology research 20070101
Mitochondrial recycling of ascorbic acid as a mechanism for regenerating cellular ascorbate. BioFactors (Oxford, England) 20070101
[Clinical significance of mustoforan in management of malignant glioma]. Voprosy onkologii 20070101
Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design. Drug target insights 20070101
Targeted brain tumor treatment-current perspectives. Drug target insights 20070101
Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance. NMR in biomedicine 20061201
Drug compatibility with new polyolefin infusion solution containers. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20061201
Proteomic analysis reveals higher demand for antioxidant protection in embryonic stem cell-derived smooth muscle cells. Proteomics 20061201
Patient with resected anaplastic astrocytoma and an image suggestive of relapse. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20061201
[Local chemotherapy for brain tumors]. Medizinische Monatsschrift fur Pharmazeuten 20061201
Autologous stem cell transplantation for progressive multiple sclerosis: update of the European Group for Blood and Marrow Transplantation autoimmune diseases working party database. Multiple sclerosis (Houndmills, Basingstoke, England) 20061201
New methods for direct delivery of chemotherapy for treating brain tumors. The Yale journal of biology and medicine 20061201
Clinical outcomes after autologous haematopoietic stem cell transplantation in patients with progressive multiple sclerosis. Chinese medical journal 20061120
Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas. Cancer 20061115
CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research 20061115
Chemotherapy for primary central nervous system lymphoma. Neurosurgical focus 20061115
Temozolomide 3 weeks on and 1 week off as first-line therapy for recurrent glioblastoma: phase II study from gruppo italiano cooperativo di neuro-oncologia (GICNO). British journal of cancer 20061106
A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma. Cancer chemotherapy and pharmacology 20061101
Expression of glutathione S-transferase T1 (GSTT1) in human brain tumours. Histology and histopathology 20061101
The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo. Journal of neurochemistry 20061101
High dose chemotherapy and autologous stem cell transplantation in non-Hodgkin's lymphoma: an eight-year experience. Yonsei medical journal 20061031
Phase II trial of radiotherapy after hyperbaric oxygenation with chemotherapy for high-grade gliomas. British journal of cancer 20061009
The multikinase inhibitor midostaurin (PKC412A) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study. British journal of cancer 20061009
Interstitial docetaxel (taxotere), carmustine and combined interstitial therapy: a novel treatment for experimental malignant glioma. Journal of neuro-oncology 20061001
Outpatient autologous hematopoietic stem cell transplantation for patients with relapsed follicular lymphoma. Annals of hematology 20061001
Autologous peripheral blood stem cell transplantation for severe multiple sclerosis. International journal of hematology 20061001
Inhibition of human glutathione transferases by multidrug resistance chemomodulators in vitro. Journal of enzyme inhibition and medicinal chemistry 20061001
Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues. Journal of medicinal chemistry 20060921
BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against Glioma C6 cells. Journal of controlled release : official journal of the Controlled Release Society 20060912
Higher incidence of chemotherapy induced oral mucositis in females: a supplement of multivariate analysis to a randomized multicentre study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20060901
Long-term follow-up of patients with peripheral T-cell lymphomas treated up-front with high-dose chemotherapy followed by autologous stem cell transplantation. Leukemia 20060901
Treatment options in relapsed or refractory Hodgkin disease patients: the mini-BEAM regimen does exist too. British journal of haematology 20060901
Characterisation of a P140K mutant O6-methylguanine-DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow. The journal of gene medicine 20060901
High-dose chemotherapy with autologous stem cell transplantation as first-line therapy for primary CNS lymphoma in patients younger than 60 years: a multicenter phase II study of the GOELAMS group. Bone marrow transplantation 20060901
Prolonged remission in a case of Richter's transformation of B-cell chronic lymphocytic leukaemia following adoptive immunotherapy. Bone marrow transplantation 20060901
Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line. Molecular cancer therapeutics 20060901
Salvage chemotherapy in follicular non-Hodgkin's lymphoma: focus on tolerability. Clinical lymphoma & myeloma 20060901
High-dose chemotherapy with autologous stem-cell transplantation and hyperfractionated radiotherapy as first-line treatment of primary CNS lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060820
Phase III trial of carmustine and cisplatin compared with carmustine alone and standard radiation therapy or accelerated radiation therapy in patients with glioblastoma multiforme: North Central Cancer Treatment Group 93-72-52 and Southwest Oncology Group 9503 Trials. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060820
Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis. Free radical biology & medicine 20060815
Dual agent chemoprotection by retroviral co-expression of either MDR1 or MRP1 with the P140K mutant of O6-methylguanine-DNA-methyl transferase. The journal of gene medicine 20060801
A phase II trial of accelerated radiotherapy using weekly stereotactic conformal boost for supratentorial glioblastoma multiforme: RTOG 0023. International journal of radiation oncology, biology, physics 20060801
Cardiac effects within 3 months of BEAC high-dose therapy in non-Hodgkin's lymphoma patients undergoing autologous stem cell transplantation. European journal of haematology 20060801
Narrowband UVB phototherapy for early-stage mycosis fungoides: evaluation of clinical and histopathological changes. Journal of the European Academy of Dermatology and Venereology : JEADV 20060801
In vitro drug response and molecular markers associated with drug resistance in malignant gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research 20060801
Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research 20060801
Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stress. Molecular cancer research : MCR 20060801
Efficacy of single-dose pegfilgrastim after chemotherapy for the mobilization of autologous peripheral blood stem cells in patients with malignant lymphoma or multiple myeloma. Transfusion 20060801
Toxicity of high dose BCNU: how much is too much? Leukemia & lymphoma 20060801
Morbidity and transplant-related mortality of CBV and BEAM preparative regimens for patients with lymphoid malignancies undergoing autologous stem-cell transplantation. Leukemia & lymphoma 20060801
A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. British journal of cancer 20060717
The role of haemoglobin level in predicting the response to first-line chemotherapy in advanced colorectal cancer patients. British journal of cancer 20060703
SarCNU in recurrent or metastatic colorectal cancer: a phase II study of the National Cancer Institute of Canada Clinical Trials Group. Investigational new drugs 20060701
Predicting and monitoring response to chemotherapy by 1,3-bis(2-chloroethyl)-1-nitrosourea in subcutaneously implanted 9L glioma using the apparent diffusion coefficient of water and 23Na MRI. Journal of magnetic resonance imaging : JMRI 20060701
Stimulation of the alveolar macrophage respiratory burst by ADP causes selective glutathionylation of protein tyrosine phosphatase 1B. Free radical biology & medicine 20060701
High-dose carmustine, etoposide, and cyclophosphamide followed by allogeneic hematopoietic cell transplantation for non-Hodgkin lymphoma. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20060701
Role of p16 and p14ARF in radio- and chemosensitivity of malignant gliomas. Oncology reports 20060701
Cellular disulfide-reducing capacity: an integrated measure of cell redox capacity. Biochemical and biophysical research communications 20060616
Upfront double high-dose chemotherapy with DICEP followed by BEAM and autologous stem cell transplantation for poor-prognosis aggressive non-Hodgkin lymphoma. Blood 20060615
Cyclin D1 degradation enhances endothelial cell survival upon oxidative stress. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060601
A prospective PET study of patients with glioblastoma multiforme. Acta neurologica Scandinavica 20060601
Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy. Cancer treatment reviews 20060601
Palifermin for oral mucositis in the high-dose chemotherapy and stem cell transplant setting: the Royal Adelaide Hospital Cancer Centre experience. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20060601
High exposures to bioactivated cyclophosphamide are related to the occurrence of veno-occlusive disease of the liver following high-dose chemotherapy. British journal of cancer 20060508
Ototoxicity of cisplatin plus standard radiation therapy vs. accelerated radiation therapy in glioblastoma patients. Journal of neuro-oncology 20060501
Response to chemotherapy of a radiation-induced glioblastoma multiforme. Journal of neuro-oncology 20060501
In vivo effects of myeloablative alkylator therapy on survival and differentiation of MGMTP140K-transduced human G-CSF-mobilized peripheral blood cells. Molecular therapy : the journal of the American Society of Gene Therapy 20060501
High-dose chemotherapy and autologous peripheral blood stem cell transplantation for primary breast cancer refractory to neoadjuvant chemotherapy. Bone marrow transplantation 20060501
Complete response in multiple myeloma: clinical trial E9486, an Eastern Cooperative Oncology Group study not involving stem cell transplantation. Cancer 20060501
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Effect of chemotherapy with alkylating agents on the yield of CD34+ cells in patients with multiple myeloma. Results of the Spanish Myeloma Group (GEM) Study. Haematologica 20060501
Minimal residual disease in hypopigmented mycosis fungoides. Journal of the American Academy of Dermatology 20060501
Dynamic imaging of emerging resistance during cancer therapy. Cancer research 20060501
Randomised phase III study of R-ICE versus R-DHAP in relapsed patients with CD20 diffuse large B-cell lymphoma (DLBCL) followed by high-dose therapy and a second randomisation to maintenance treatment with rituximab or not: an update of the CORAL study. Annals of oncology : official journal of the European Society for Medical Oncology 20060501
Successful autologous hematopoietic stem cell transplantations for severe multiple sclerosis with fludarabine and cyclophosphamide conditioning. International journal of hematology 20060501
Causes and outcomes of spontaneous pneumothoraces in solid tumor cancer patients: an update for the medical oncologist. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20060501
The novel antioxidant 3-O-caffeoyl-1-methylquinic acid induces Nrf2-dependent phase II detoxifying genes and alters intracellular glutathione redox. Free radical biology & medicine 20060415
The IL-4 and IL-13 pseudomonas exotoxins: new hope for brain tumor therapy. Neurosurgical focus 20060415
Management of malignant glioma: steady progress with multimodal approaches. Neurosurgical focus 20060415
Cardiac toxicity of trastuzumab in metastatic breast cancer patients previously treated with high-dose chemotherapy: a retrospective study. British journal of cancer 20060410
Safety and efficacy of a novel cannabinoid chemotherapeutic, KM-233, for the treatment of high-grade glioma. Journal of neuro-oncology 20060401
Sodium and proton diffusion MRI as biomarkers for early therapeutic response in subcutaneous tumors. Magnetic resonance imaging 20060401
Circulating levels and clinical significance of soluble CD86 in myeloma patients. British journal of haematology 20060401
The functional diffusion map: an imaging biomarker for the early prediction of cancer treatment outcome. Neoplasia (New York, N.Y.) 20060401
Permeability of 13 different gloves to 13 cytotoxic agents under controlled dynamic conditions. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060315
Summaries for patients. Adding chloroquine to conventional chemotherapy and radiotherapy for glioblastoma multiforme. Annals of internal medicine 20060307
Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial. Annals of internal medicine 20060307
Immune thrombocytopenia following successful treatment of cancer in children. Pediatric blood & cancer 20060301
O(6)-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C. Toxicology and applied pharmacology 20060301
Intracavitary chemotherapy (Gliadel) for recurrent esthesioneuroblastoma: case report and review of the literature. Journal of neuro-oncology 20060301
Redox control of K+ channel remodeling in rat ventricle. Journal of molecular and cellular cardiology 20060301
Efficacy of diverse high-dose regimens followed by autologous peripheral blood stem cell transplantation in consecutive multiple myeloma patients: a single-centre analysis over a 12-year period. Annals of hematology 20060301
Acute depletion of reduced glutathione causes extensive carbonylation of rat brain proteins. Journal of neuroscience research 20060301
Cancer therapy-associated CNS neuropathology: an update and review of the literature. Acta neuropathologica 20060301
Gliadel wafer in initial surgery for malignant glioma: long-term follow-up of a multicenter controlled trial. Acta neurochirurgica 20060301
Inhibition of vascular endothelial growth factor (VEGF)-A causes a paradoxical increase in tumor blood flow and up-regulation of VEGF-D. Clinical cancer research : an official journal of the American Association for Cancer Research 20060301
[Management of malignant gliomas diagnosed during pregnancy]. Revue neurologique 20060301
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20060301
[Sensitivity profile of a panel of cell lines designed for the evaluation of in vitro cytotoxicity]. Biomedica : revista del Instituto Nacional de Salud 20060301
Standard chemotherapy compared with high-dose chemoradiotherapy for multiple myeloma: final results of phase III US Intergroup Trial S9321. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060220
Involvement of NF-kappaB and glutathione in cytotoxic effects of nitric oxide and taxol on human leukemia cells. Leukemia research 20060201
DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors. The Journal of pharmacology and experimental therapeutics 20060201
Successful autologous peripheral blood stem cell harvest and transplant in a patient with cold agglutinins. Bone marrow transplantation 20060201
Results of a phase I/II trial adding carmustine (300 mg/m2) to melphalan (200 mg/m2) in multiple myeloma patients undergoing autologous stem cell transplantation. Leukemia 20060201
O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells. Journal of neurochemistry 20060201
Comparison of peripheral blood progenitor cell yield from standard chemotherapy used in the treatment of lymphoid malignancies and high-dose cyclophosphamide: a retrospective review of 141 patients. Transfusion 20060201
Consolidation with high-dose combination alkylating agents with bone marrow transplantation significantly improves disease-free survival in hormone-insensitive metastatic breast cancer in complete remission compared with intensive standard-dose chemotherapy alone. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20060201
Glioblastoma--more questions than answers? Nature clinical practice. Oncology 20060201
Clinical experience: practical management of five patients with cutaneous T-cell lymphoma (CTCL)-related symptoms. Seminars in oncology 20060201
Similar response rates and superior early progression-free survival with gemcitabine, dexamethasone, and cisplatin salvage therapy compared with carmustine, etoposide, cytarabine, and melphalan salvage therapy prior to autologous stem cell transplantation for recurrent or refractory Hodgkin lymphoma. Cancer 20060115
Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060110
Trial of amifostine in autologous stem cell transplant. Bone marrow transplantation 20060101
Prophylaxis of central venous catheter-related thrombosis with minidose warfarin in patients treated with high-dose chemotherapy and peripheral-blood stem-cell transplantation: retrospective analysis of 228 cancer patients. American journal of hematology 20060101
Over-representation of specific regions of chromosome 22 in cells from human glioma correlate with resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea. BMC cancer 20060101
Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Molecular cancer therapeutics 20060101
Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI. Virology journal 20060101
An unusual cause of alveolar hemorrhage post hematopoietic stem cell transplantation: a case report. BMC cancer 20060101
Solitary pulmonary metastasis from primary melanoma of the oesophagus 5 years after resection of the primary tumor. World journal of surgical oncology 20060101
Intraprostatic injection of botulinum toxin type-A relieves bladder outlet obstruction in human and induces prostate apoptosis in dogs. BMC urology 20060101
Treatments for astrocytic tumors in children: current and emerging strategies. Paediatric drugs 20060101
Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells. BMC complementary and alternative medicine 20060101
Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I'm-Yunity (PSP). BMC complementary and alternative medicine 20060101
Glioblastoma multiforme with oligodendroglial component (GBMO): favorable outcome after post-operative radiotherapy and chemotherapy with nimustine (ACNU) and teniposide (VM26). BMC cancer 20060101
Primary brain T-cell lymphoma after kidney transplantation: a case report. Surgical neurology 20060101
Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells. BioFactors (Oxford, England) 20060101
CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. Journal of biology 20060101
The long term effects of chemotherapy on the central nervous system. Journal of biology 20060101
Treatment of mycosis fungoides: overview. Journal of cutaneous medicine and surgery 20060101
[Boron neutron capture therapy applied to undifferentiated thyroid carcinoma]. Medicina 20060101
Prooxidant cytotoxicity of chromate in mammalian cells: the opposite roles of DT-diaphorase and glutathione reductase. Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101
Bortezomib: the evidence of its clinical impact in multiple myeloma. Core evidence 20060101
Involvement of the immune response in the cure of metastatic murine CT-26 colon carcinoma by low electric field-enhanced chemotherapy. International journal of cancer 20051210
Phase II trial of SarCNU in malignant glioma: unexpected pulmonary toxicity with a novel nitrosourea: a phase II trial of the national cancer institute of canada clinical trials group. Investigational new drugs 20051201
High-dose therapy intensification compared with continued standard chemotherapy in multiple myeloma patients responding to the initial chemotherapy: long-term results from a prospective randomized trial from the Spanish cooperative group PETHEMA. Blood 20051201
Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities. The Journal of pharmacology and experimental therapeutics 20051201
Very acute cardiac toxicity during BEAC chemotherapy in non-Hodgkin's lymphoma patients undergoing autologous stem cell transplantation. Bone marrow transplantation 20051201
[Treatment for malignant glioma]. No to shinkei = Brain and nerve 20051201
Hematopoietic stem cell transduction and amplification in large animal models. Human gene therapy 20051201
Interstitial transfer factor as adjuvant immunotherapy for experimental glioma. Journal of experimental & clinical cancer research : CR 20051201
Sensitization of human carcinoma cells to alkylating agents by small interfering RNA suppression of 3-alkyladenine-DNA glycosylase. Cancer research 20051115
O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts. British journal of cancer 20051114
Occurrence of multiple myeloma 13 years after Hodgkin's disease: chance or consequence? Annals of hematology 20051101
A novel thiol oxidation-based mechanism for adriamycin-induced cell injury in human macrophages. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051101
Chemotherapy in brain metastases. Neurosurgery 20051101
Current treatment paradigms for the management of patients with brain metastases. Neurosurgery 20051101
Intra-arterial chemotherapy of primary brain tumors. Current treatment options in oncology 20051101
Role of O6-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine. Molecular cancer therapeutics 20051101
Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research 20051101
Quality of life among patients with Stage II and III breast carcinoma randomized to receive high-dose chemotherapy with autologous bone marrow support or intermediate-dose chemotherapy: results from Cancer and Leukemia Group B 9066. Cancer 20051015
Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors. Clinical cancer research : an official journal of the American Association for Cancer Research 20051015
2-Chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU) exhibits p53-dependent and -independent antiproliferative activity in human nasopharyngeal carcinoma cells in vitro and in vivo. International journal of oncology 20051001
Ifosfamide, epirubicin, etoposide (IEV) and autologous peripheral blood progenitor cell transplant: a feasible and effective salvage treatment for lymphoid malignancies. Oncology reports 20051001
First-line autologous stem cell transplantation in primary CNS lymphoma. European journal of haematology 20051001
Augmented high-dose regimen of cyclophosphamide, carmustine, and etoposide with autologous hematopoietic stem cell transplantation for relapsed and refractory aggressive non-Hodgkin's lymphoma. Leukemia & lymphoma 20051001
Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action. Journal of biotechnology 20050929
Recent clinical studies of the immunomodulatory drug (IMiD) lenalidomide. British journal of cancer 20050919
Quantitative structure-activity relationships in prooxidant cytotoxicity of polyphenols: role of potential of phenoxyl radical/phenol redox couple. Archives of biochemistry and biophysics 20050915
Enhancement of the stability of BCNU using self-emulsifying drug delivery systems (SEDDS) and in vitro antitumor activity of self-emulsified BCNU-loaded PLGA wafer. International journal of pharmaceutics 20050914
Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies. British journal of cancer 20050905
SarCNU-induced G2/M arrest in hepatoma cells is mediated by a p53-independent phosphorylation of cdc-2 at Tyr15. Journal of cellular physiology 20050901
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds. Free radical biology & medicine 20050901
Associations between drug metabolism genotype, chemotherapy pharmacokinetics, and overall survival in patients with breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050901
The American Society for Therapeutic Radiology and Oncology (ASTRO) evidence-based review of the role of radiosurgery for malignant glioma. International journal of radiation oncology, biology, physics 20050901
Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas. Molecular cancer therapeutics 20050901
Retinamide-induced apoptosis in glioblastomas is associated with down-regulation of Bcl-xL and Bcl-2 proteins. Journal of neuro-oncology 20050901
Inactivation of p53 sensitizes astrocytic glioma cells to BCNU and temozolomide, but not cisplatin. Journal of neuro-oncology 20050901
Local treatment of malignant brain tumors using implantable chemotherapeutic polymers. Journal of the National Comprehensive Cancer Network : JNCCN 20050901
Pharmaceutical-mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide. International journal of cancer 20050820
In vivo delivery of BCNU from a MEMS device to a tumor model. Journal of controlled release : official journal of the Controlled Release Society 20050818
2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino)- phenylcarbamoylsulfanyl]propionic acid and its derivatives as a novel class of glutathione reductase inhibitors. Journal of medicinal chemistry 20050811
Autologous tandem transplantation in patients with primary progressive or relapsed/refractory lymphoma. Annals of hematology 20050801
Biphasic lindane-induced oxidation of glutathione and inhibition of gap junctions in myometrial cells. Toxicological sciences : an official journal of the Society of Toxicology 20050801
High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. Annals of oncology : official journal of the European Society for Medical Oncology 20050801
The influence of ATP on poly(ADP-ribose) metabolism. International journal of molecular medicine 20050801
Primary brain tumors treated with steroids and radiotherapy: low CD4 counts and risk of infection. International journal of radiation oncology, biology, physics 20050801
Research on the anti-tumour effect of steroid lactam alkylator (NSC-294859) in comparison with conventional chemotherapeutics in malignant melanoma. Melanoma research 20050801
Chemoembolization of the hepatic artery with BCNU for metastatic uveal melanoma: results of a phase II study. Melanoma research 20050801
Successful bone marrow transplantation for life threatening xanthogranuloma disseminatum in neurofibromatosis type-1. Pediatric transplantation 20050801
Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research 20050715
Long-term results of autologous stem cell transplantation for Hodgkin's disease (HD) and low-/intermediate-grade B non-Hodgkin's lymphoma (NHL): a report from the Austrian Stem Cell Transplantation Registry (ASCTR). Annals of hematology 20050701
The comparative effects of povidone-iodine and normal saline mouthwashes on oral mucositis in patients after high-dose chemotherapy and APBSCT--results of a randomized multicentre study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20050701
Temozolomide in combination with BCNU before and after radiotherapy in patients with inoperable newly diagnosed glioblastoma multiforme. Annals of oncology : official journal of the European Society for Medical Oncology 20050701
BAVC regimen and autologous bone marrow transplantation for APL patients in second molecular remission: updated results. Bone marrow transplantation 20050701
Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. Journal of neuro-oncology 20050701
Intratumoral injection of BCNU in ethanol (DTI-015) results in enhanced delivery to tumor--a pharmacokinetic study. Journal of neuro-oncology 20050701
Mini-BEAM and autologous hematopoietic stem-cell transplant for treatment of post-transplant lymphoproliferative disorders. American journal of hematology 20050701
A phase Ib clinical trial of PV701, a milk-derived protein extract, for the prevention and treatment of oral mucositis in patients undergoing high-dose BEAM chemotherapy. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20050701
The role of interferon-alpha in a successful murine tumor therapy. Experimental biology and medicine (Maywood, N.J.) 20050701
Treatment of brain tumors. The New England journal of medicine 20050602
Late mortality in survivors of autologous hematopoietic-cell transplantation: report from the Bone Marrow Transplant Survivor Study. Blood 20050601
Impact of three courses of intensified CHOP prior to high-dose sequential therapy followed by autologous stem-cell transplantation as first-line treatment in poor-risk, aggressive non-hodgkin's lymphoma: comparative analysis of Dutch-Belgian Hemato-Oncology Cooperative Group Studies 27 and 40. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050601
In regard to Dr. Souhami et al. (Int J Radiat Oncol Biol Phys 2004;60:853-860). International journal of radiation oncology, biology, physics 20050601
Evaluation of the effect of age on treatment-related mortality and relapse in patients with high-risk primary breast cancer receiving high-dose chemotherapy. American journal of clinical oncology 20050601
Long-term follow up of high-dose chemotherapy with autologous stem cell rescue in adults with Ewing tumor. American journal of clinical oncology 20050601
NGF rescues DRG neurons in vitro from oxidative damage produced by hemodialyzers. Neurotoxicology 20050601
Prognostic value of the age-adjusted International Prognostic Index in chemosensitive recurrent or refractory non-Hodgkin's lymphomas treated with high-dose BEAM therapy and autologous stem cell transplantation. Leukemia & lymphoma 20050601
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20050601
Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU. Biochemical pharmacology 20050515
Cylindrospermopsin genotoxicity and cytotoxicity: role of cytochrome P-450 and oxidative stress. Journal of toxicology and environmental health. Part A 20050514
HMG CoA reductase inhibitors (statins) to treat Epstein-Barr virus-driven lymphoma. British journal of cancer 20050509
Lack of survival benefit after stereotactic radiosurgery boost for glioblastoma multiforme: randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of radiation therapy oncology group 93-05 protocol: in regard to Souhami et al. (Int J Radiat Oncol Biol Phys 2004;60:853-860). International journal of radiation oncology, biology, physics 20050501
A phase I trial of surgery, Gliadel wafer implantation, and immediate postoperative carboplatin in combination with radiation therapy for primary anaplastic astrocytoma or glioblastoma multiforme. Journal of neuro-oncology 20050501
S-nitrosoglutathione and hypoxia-inducible factor-1 confer chemoresistance against carbamoylating cytotoxicity of BCNU in rat C6 glioma cells. Annals of the New York Academy of Sciences 20050501
Gemcitabine, cisplatin and methylprednisolone (GEM-P) is an effective salvage regimen in patients with relapsed and refractory lymphoma. British journal of cancer 20050425
Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents. Cancer research 20050415
Prospective, randomized comparison of high-dose chemotherapy with stem-cell support versus intermediate-dose chemotherapy after surgery and adjuvant chemotherapy in women with high-risk primary breast cancer: a report of CALGB 9082, SWOG 9114, and NCIC MA-13. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050401
Concurrent administration of high-dose rituximab before and after autologous stem-cell transplantation for relapsed aggressive B-cell non-Hodgkin's lymphomas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050401
Nephrotic syndrome in patients with peripheral blood stem cell transplant. American journal of kidney diseases : the official journal of the National Kidney Foundation 20050401
O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research 20050401
Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. Chemistry & biology 20050401
Inactivated MGMT by O6-benzylguanine is associated with prolonged G2/M arrest in cancer cells treated with BCNU. Oncogene 20050324
Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life. Blood 20050315
An analysis of the utilisation of chemoprophylaxis against Pneumocystis jirovecii pneumonia in patients with malignancy receiving corticosteroid therapy at a cancer hospital. British journal of cancer 20050314
Combined chemotherapy with carmustine, doxorubicin, etoposide, vincristine, and cyclophosphamide plus mitoxantrone, cytarabine and methotrexate with citrovorum factor for the treatment of aggressive non-Hodgkin lymphoma: a long-term follow-up study. Cancer 20050301
Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy. Blood 20050201
CD8+ T-cell-depleted, matched unrelated donor, allogeneic bone marrow transplantation for advanced AML using busulfan-based preparative regimens. Bone marrow transplantation 20050201
Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells. Anti-cancer drugs 20050201
Phase II trial of carmustine, cisplatin, and oral etoposide chemotherapy before radiotherapy for grade 3 astrocytoma (anaplastic astrocytoma): results of North Central Cancer Treatment Group trial 98-72-51. International journal of radiation oncology, biology, physics 20050201
Lack of EGF receptor contributes to drug sensitivity of human germline cells. British journal of cancer 20050131
Phase I trial of iodine-131 tositumomab with high-dose chemotherapy and autologous stem-cell transplantation for relapsed non-Hodgkin's lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050120
A non-crosslinking platinum-acridine hybrid agent shows enhanced cytotoxicity compared to clinical BCNU and cisplatin in glioblastoma cells. Bioorganic & medicinal chemistry letters 20050117
Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine. Journal of medicinal chemistry 20050113
Differential effects of glucose deprivation on the cellular sensitivity towards photodynamic treatment-based production of reactive oxygen species and apoptosis-induction. FEBS letters 20050103
Venous thromboembolism after high-dose chemotherapy in a patient with Hodgkin's lymphoma receiving the new oral contraceptive ethinylestradiol and drospirenone ('Yasmine'). Bone marrow transplantation 20050101
Evaluation of in vitro and in vivo antitumor activity of BCNU-loaded PLGA wafer against 9L gliosarcoma. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050101
Cologne high-dose sequential chemotherapy in relapsed and refractory Hodgkin lymphoma: results of a large multicenter study of the German Hodgkin Lymphoma Study Group (GHSG). Annals of oncology : official journal of the European Society for Medical Oncology 20050101
High-dose carmustine, etoposide, and cisplatin for autologous stem cell transplantation with or without involved-field radiation for relapsed/refractory lymphoma: an effective regimen with low morbidity and mortality. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20050101
Response to chemotherapy and treating institution predict survival in primary central nervous system lymphoma. British journal of haematology 20050101
Effect of pre-transplant cumulative doses of chemotherapeutic drugs on early and long-term hematological recovery after autologous bone-marrow transplantation for lymphoma. Haematologica 20050101
[Effect of photodynamic therapy combined with interstitial chemotherapy for gliomas]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050101
Photodynamic treatment with fractionated light decreases production of reactive oxygen species and cytotoxicity in vitro via regeneration of glutathione. Photochemistry and photobiology 20050101
Sodium magnetic resonance imaging of chemotherapeutic response in a rat glioma. Magnetic resonance in medicine 20050101
Cerebral edema associated with Gliadel wafers: two case studies. Neuro-oncology 20050101
Cyclosporine A, alpha-lnterferon and interleukin-2 following chemotherapy with BCNU, DTIC, cisplatin, and tamoxifen: a phase II study in advanced melanoma. Cancer investigation 20050101
Combination chemotherapy with carmustine and cisplatin followed by procarbazine, lomustine, and vincristine for adult high-grade astrocytoma. Chang Gung medical journal 20050101
Synthesis and characterization of polyanhydride for local BCNU delivery carriers. Bio-medical materials and engineering 20050101
[Combined treatment of glyal and metastatic tumors of the brain]. Vestnik khirurgii imeni I. I. Grekova 20050101
FNAB cytology of extra-cranial metastasis of glioblastoma multiforme may resemble a lung primary: a diagnostic pitfall. CytoJournal 20050101
Hodgkin's disease as unusual presentation of post-transplant lymphoproliferative disorder after autologous hematopoietic cell transplantation for malignant glioma. BMC cancer 20050101
Long-term disease-free survival in advanced melanomas treated with nitrosoureas: mechanisms and new perspectives. BMC cancer 20050101
Local delivery of doxorubicin for the treatment of malignant brain tumors in rats. Anticancer research 20050101
Redox properties of novel antioxidant 5,8-Dihydroxycoumarin: implications for its prooxidant cytotoxicity. Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101
Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin. The Journal of biological chemistry 20041224
2-Chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU) inhibits prostate carcinoma cell growth via p53-dependent and p53-independent pathways. Cancer 20041215
Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors. Clinical cancer research : an official journal of the American Association for Cancer Research 20041215
Ex vivo expansion of megakaryocyte precursor cells in autologous stem cell transplantation for relapsed malignant lymphoma. Bone marrow transplantation 20041201
Low electric field enhanced chemotherapy can cure mice with CT-26 colon carcinoma and induce anti-tumour immunity. Clinical and experimental immunology 20041201
Second-line chemotherapy with irinotecan plus carmustine in glioblastoma recurrent or progressive after first-line temozolomide chemotherapy: a phase II study of the Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO). Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20041201
Therapeutic efficacy of DTI-015 using diffusion magnetic resonance imaging as an early surrogate marker. Clinical cancer research : an official journal of the American Association for Cancer Research 20041201
Phase I study for poor-prognosis lymphoma: augmentation of the 'BEAM' regimen with escalating dose melphalan using amifostine cytoprotection and autologous hematopoietic stem cell transplantation--a preliminary report. Seminars in oncology 20041201
Enhancement of genotoxic effects in the comet assay with human blood samples by aphidicolin. Toxicology letters 20041128
In vivo release from a drug delivery MEMS device. Journal of controlled release : official journal of the Controlled Release Society 20041124
Alkylation damage in DNA and RNA--repair mechanisms and medical significance. DNA repair 20041102
Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection. Gene therapy 20041101
Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of Radiation Therapy Oncology Group 93-05 protocol. International journal of radiation oncology, biology, physics 20041101
The use of high-dose cyclophosphamide, carmustine, and thiotepa plus autologous hematopoietic stem cell transplantation as consolidation therapy for high-risk primary breast cancer after primary surgery or neoadjuvant chemotherapy. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20041101
Phase II feasibility and pharmacokinetic study of concurrent administration of trastuzumab and high-dose chemotherapy in advanced HER2+ breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20041101
Invasive phenotype observed in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant sublines of 9L rat glioma cells: a tumor model mimicking a recurrent malignant glioma. Journal of neurosurgery 20041101
How effective is BCNU in recurrent glioblastoma in the modern era? A phase II trial. Neurology 20041012
A spinal cord intravascular lymphomatosis with exceptionally good outcome. Neurology 20041012
Functional significance of the pentose phosphate pathway and glutathione reductase in the antioxidant defenses of human sperm. Biology of reproduction 20041001
Systemic BCNU enhances the efficacy of local delivery of a topoisomerase I inhibitor against malignant glioma. Cancer chemotherapy and pharmacology 20041001
High-dose CEB vs BEAM with autologous stem cell transplant in lymphoma. Bone marrow transplantation 20041001
Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2. Bone marrow transplantation 20041001
A long-term follow-up of 33 patients with non-Hodgkin's lymphoma who received the BEAM high-dose intensification regimen with cytokine support only and no transplant. Leukemia 20041001
Results of autologous transplantation in lymphoma are not improved by increasing the dose of etoposide in the BEAM regimen: a single-centre sequential-cohort study. Bone marrow transplantation 20041001
In vitro cytotoxicity of epigallocatechin gallate and tea extracts to cancerous and normal cells from the human oral cavity. Basic & clinical pharmacology & toxicology 20041001
Combination chemotherapy of BCNU and Didox acts synergystically in 9L glioma cells. Nucleosides, nucleotides & nucleic acids 20041001
Does stereotactic eligibility for the treatment of glioblastoma cause selection bias in randomized studies? American journal of clinical oncology 20041001
[Comparision of high dose impulsion and low dose density chemotherapeutic regimens with paclitaxel plus cisplatin in advanced NSCLC]. Zhonghua zhong liu za zhi [Chinese journal of oncology] 20041001
Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. International journal of cancer 20040910
25-year study of lung fibrosis following carmustine therapy for brain tumor in childhood. Chest 20040901
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations. Molecular cancer therapeutics 20040901
The glutathione reductase inhibitor carmustine induces an influx of Ca2+ in PC12 cells. European journal of pharmacology 20040816
UV light increases vitamin C uptake by bovine lens epithelial cells. Molecular vision 20040806
Temozolomide in paediatric high-grade glioma: a key for combination therapy? British journal of cancer 20040802
Synergistic cytotoxicity of the ribonucleotide reductase inhibitor didox (3,4-dihydroxy-benzohydroxamic acid) and the alkylating agent carmustine (BCNU) in 9L rat gliosarcoma cells and DAOY human medulloblastoma cells. Cancer chemotherapy and pharmacology 20040801
CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research 20040801
Pharmacokinetics of O(6)-benzylguanine in pediatric patients with central nervous system tumors: a pediatric oncology group study. Clinical cancer research : an official journal of the American Association for Cancer Research 20040801
Lentivirus-mediated expression of mutant MGMTP140K protects human CD34+ cells against the combined toxicity of O6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide. Human gene therapy 20040801
Interstitial lung disease associated with drug therapy. British journal of cancer 20040801
Diagnosis and management of drug-associated interstitial lung disease. British journal of cancer 20040801
Phase I trial of the novel taxane BMS-184476 administered in combination with carboplatin every 21 days. British journal of cancer 20040719
Phase I study pilot arms of radiotherapy and carmustine with temozolomide for anaplastic astrocytoma (Radiation Therapy Oncology Group 9813): implications for studies testing initial treatment of brain tumors. International journal of radiation oncology, biology, physics 20040715
2-amino-O4-benzylpteridine derivatives: potent inactivators of O6-alkylguanine-DNA alkyltransferase. Journal of medicinal chemistry 20040715
Combination of caspase transfer using the human telomerase reverse transcriptase promoter and conventional therapies for malignant glioma cells. International journal of oncology 20040701
Tributyltin-sulfhydryl interaction as a cause of immunotoxicity in phagocytes of tunicates. Ecotoxicology and environmental safety 20040701
Distinct responses of xenografted gliomas to different alkylating agents are related to histology and genetic alterations. Cancer research 20040701
Effects on Walker 256 tumour of carmustine associated with a cholesterol-rich microemulsion (LDE). The Journal of pharmacy and pharmacology 20040701
In vitro evaluation of dimethane sulfonate analogues with potential alkylating activity and selective renal cell carcinoma cytotoxicity. Molecular cancer therapeutics 20040701
Phase 1 study of 28-day, low-dose temozolomide and BCNU in the treatment of malignant gliomas after radiation therapy. Neuro-oncology 20040701
BCNU down-regulates anti-apoptotic proteins bcl-xL and Bcl-2 in association with cell death in oligodendroglioma-derived cells. Journal of neuro-oncology 20040701
Four-year survival after trans-jugular intrahepatic porto-systemic shunt for veno-occlusive disease following autologous bone marrow transplantation. Leukemia & lymphoma 20040701
Primary non-Hodgkin's lymphoma of the CNS treated with CHOD/BVAM or BVAM chemotherapy before radiotherapy: long-term survival and prognostic factors. International journal of radiation oncology, biology, physics 20040601
Infused CD34 cell dose, but not tumour cell content of peripheral blood progenitor cell grafts, predicts clinical outcome in patients with diffuse large B-cell lymphoma and follicular lymphoma grade 3 treated with high-dose therapy. British journal of haematology 20040601
DNA damage-processing pathways involved in the eukaryotic cellular response to anticancer DNA cross-linking drugs. Molecular pharmacology 20040601
[Study on MGMT assay and tumor individual predictable chemotherapy]. Ai zheng = Aizheng = Chinese journal of cancer 20040601
Polymorphism of human mu class glutathione transferases. Pharmacogenetics 20040601
Chemotherapy in metastatic gastric cancer: population-based perceptions and practice patterns of medical oncologists. British journal of cancer 20040517
Nitric oxide and BCNU chemoresistance in C6 glioma cells: role of S-nitrosoglutathione. Free radical biology & medicine 20040515
Flavoenzyme-catalyzed redox cycling of hydroxylamino- and amino metabolites of 2,4,6-trinitrotoluene: implications for their cytotoxicity. Archives of biochemistry and biophysics 20040515
Hammerhead ribozyme-mediated sensitization of human tumor cells after treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea. The Journal of pharmacology and experimental therapeutics 20040501
BCNU as second line therapy for recurrent high-grade glioma previously treated with Temozolomide. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20040501
Phase I study of involved-field radiotherapy preceding autologous stem cell transplantation for patients with high-risk lymphoma or Hodgkin's disease. International journal of radiation oncology, biology, physics 20040501
Interstitial infusion of carmustine in the rat brain stem with systemic administration of O6-benzylguanine. Journal of neuro-oncology 20040501
Phase II study of neoadjuvant 1, 3-bis (2-chloroethyl)-1-nitrosourea and temozolomide for newly diagnosed anaplastic glioma: a North American Brain Tumor Consortium Trial. Cancer 20040415
Inhibition of cell signaling by the combi-nitrosourea FD137 in the androgen independent DU145 prostate cancer cell line. The Prostate 20040401
Cloning and expression of canine O6-methylguanine-DNA methyltransferase in target cells, using gammaretroviral and lentiviral vectors. Human gene therapy 20040401
A randomized trial of amifostine and carmustine-containing chemotherapy to assess lung-protective effects. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20040401
Phase 2 trial of BCNU plus irinotecan in adults with malignant glioma. Neuro-oncology 20040401
Phase 1 trial of irinotecan plus BCNU in patients with progressive or recurrent malignant glioma. Neuro-oncology 20040401
Salvage chemotherapy with cyclophosphamide for recurrent, temozolomide-refractory glioblastoma multiforme. Cancer 20040315
Compartmental inhibition of hepatic glutathione reductase activities by 1,3-bis(2-chloroethyl)-N-nitrosourea (BCNU) in Sprague-Dawley and Fischer-344 rats. Toxicology letters 20040307
Autologous peripheral blood stem cell transplantation with BCVAC conditioning in childhood acute myeloid leukemia. Bone marrow transplantation 20040301
A single prior course of BCNU-cisplatin chemotherapy has a significant deleterious effect on mobilization kinetics of otherwise untreated patients. Bone marrow transplantation 20040301
Carbamoylating chemoresistance induced by cobalt pretreatment in C6 glioma cells: putative roles of hypoxia-inducible factor-1. British journal of pharmacology 20040301
Cellular glutathione prevents cytolethality of monomethylarsonic acid. Toxicology and applied pharmacology 20040301
A randomized phase I and pharmacological trial of sequences of 1,3-bis(2-chloroethyl)-1-nitrosourea and temozolomide in patients with advanced solid neoplasms. Clinical cancer research : an official journal of the American Association for Cancer Research 20040301
Cognitive status and quality of life after treatment for primary CNS lymphoma. Neurology 20040224
Pharmacokinetics of high-dose chemotherapy. Bone marrow transplantation 20040201
In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication. Molecular therapy : the journal of the American Society of Gene Therapy 20040201
Pattern of recurrence following local chemotherapy with biodegradable carmustine (BCNU) implants in patients with glioblastoma. Journal of neuro-oncology 20040201
BEAM-alemtuzumab reduced-intensity allogeneic stem cell transplantation for lymphoproliferative diseases: GVHD, toxicity, and survival in 65 patients. Blood 20040115
Metabolism of a cholesterol-rich microemulsion (LDE) in patients with multiple myeloma and a preliminary clinical study of LDE as a drug vehicle for the treatment of the disease. Cancer chemotherapy and pharmacology 20040101
Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers. Investigational new drugs 20040101
Increased exhaled nitric oxide following autologous peripheral hematopoietic stem-cell transplantation: a potential marker of idiopathic pneumonia syndrome. Chest 20040101
Medical devices of the head, neck, and spine. Radiographics : a review publication of the Radiological Society of North America, Inc 20040101
Comparison of BAVC to BuCy regimens in autologous stem cell transplantation for adult patients with acute myeloid leukemia. Haematologica 20040101
Phase 2 study of BCNU and temozolomide for recurrent glioblastoma multiforme: North American Brain Tumor Consortium study. Neuro-oncology 20040101
Hemopoietic recovery and infectious complications in breast cancer and multiple myeloma after autologous CD34+ cell-selected peripheral blood progenitor cell transplantation. International journal of hematology 20040101
Clinical course and pathologic findings after Gliadel and radiotherapy for newly diagnosed malignant glioma: implications for patient management. Cancer investigation 20040101
Advancing the treatment of malignant glioma: act local, think global. Cancer investigation 20040101
Pre-irradiation chemotherapy for newly diagnosed high grade astrocytoma. Anticancer research 20040101
Carmustine, vincristine, and prednisone in the treatment of canine lymphosarcoma. Journal of the American Animal Hospital Association 20040101
Current management strategies for cutaneous T-cell lymphoma. Clinics in dermatology 20040101
Myeloablative radiochemotherapy followed by autologous peripheral blood stem cell transplantation as first-line therapy in peripheral T-cell lymphomas: first results of a prospective multicenter study. The hematology journal : the official journal of the European Haematology Association 20040101
Dexamethasone protected human glioblastoma U87MG cells from temozolomide induced apoptosis by maintaining Bax:Bcl-2 ratio and preventing proteolytic activities. Molecular cancer 20040101
[Autologous stem-cell transplantations in children with non-Hodgkin lymphomas]. Przeglad lekarski 20040101
Glutathione reductase is expressed at high levels in pancreatic islet cells. Redox report : communications in free radical research 20040101
[Use of dexamethasone in treatment of high- and low-grade non-Hodgkin's lymphoma]. Voprosy onkologii 20040101
Enzymatic redox properties of novel nitrotriazole explosives implications for their toxicity. Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101
Bis(Chloroethyl) nitrosourea. Report on carcinogens : carcinogen profiles 20040101
High-dose methotrexate-based chemotherapy followed by consolidating radiotherapy in non-AIDS-related primary central nervous system lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20031215
In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations. Human gene therapy 20031210
High-dose therapy and autologous peripheral-blood stem-cell transplantation as salvage treatment for HIV-associated lymphoma in patients receiving highly active antiretroviral therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20031201
Peroxide toxicity in conditioned lens epithelial cells--evaluation of multi-defense systems. Experimental eye research 20031201
High-dose chemotherapy and autologous stem cell transplantation in peripheral T-cell lymphoma: the GEL-TAMO experience. Annals of oncology : official journal of the European Society for Medical Oncology 20031201
Systemic chemotherapy in the treatment of malignant melanoma. Expert opinion on pharmacotherapy 20031201
Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea. Molecular cancer therapeutics 20031201
State-of-the-art treatment of high-grade brain tumors. Seminars in oncology 20031201
Arguments against the routine use of currently available adjuvant chemotherapy in high-grade gliomas. Seminars in oncology 20031201
A phase I (tumour site-specific) study of carboplatin and temozolomide in patients with advanced melanoma. British journal of cancer 20031117
Intensive methotrexate and cytarabine followed by high-dose chemotherapy with autologous stem-cell rescue in patients with newly diagnosed primary CNS lymphoma: an intent-to-treat analysis. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20031115
In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning. The Journal of clinical investigation 20031115
Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model. The Journal of clinical investigation 20031115
Cytotoxicity, DNA damage, and apoptosis induced by new fotemustine analogs on human melanoma cells in relation to O6-methylguanine DNA-methyltransferase expression. The Journal of pharmacology and experimental therapeutics 20031101
Miscoding properties of 1,N6-ethanoadenine, a DNA adduct derived from reaction with the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea. Mutation research 20031029
O6-methylguanine-DNA-methyltransferase expression and gene polymorphisms in relation to chemotherapeutic response in metastatic melanoma. British journal of cancer 20031020
Response of recurrent anaplastic ependymoma to a combination of tamoxifen and isotretinoin. Neurology 20031014
Polymorphic variation in GSTP1 modulates outcome following therapy for multiple myeloma. Blood 20031001
Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics. Toxicological sciences : an official journal of the Society of Toxicology 20031001
Ex vivo B cell depletion using the Eligix B Cell SC system and autologous peripheral blood stem cell transplantation in patients with follicular non-Hodgkin's lymphoma. Bone marrow transplantation 20031001
Blockage of abasic site repair enhances antitumor efficacy of 1,3-bis-(2-chloroethyl)-1-nitrosourea in colon tumor xenografts. Molecular cancer therapeutics 20031001
Management of mycosis fungoides: Part 2. Treatment. Oncology (Williston Park, N.Y.) 20031001
Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantation. Blood 20030915
Enhanced DNA excision repair in CCRF-CEM cells resistant to 1,3-bis(2-chloroethyl)-1-nitrosourea, quantitated using the single cell gel electrophoresis (Comet) assay. Biochemical pharmacology 20030915
Neuro-Oncology Working Group 01 trial of nimustine plus teniposide versus nimustine plus cytarabine chemotherapy in addition to involved-field radiotherapy in the first-line treatment of malignant glioma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030901
A bicistronic SIN-lentiviral vector containing G156A MGMT allows selection and metabolic correction of hematopoietic protoporphyric cell lines. The journal of gene medicine 20030901
Regulation of glutathione in cardiac myocytes. Journal of molecular and cellular cardiology 20030901
[Study on drug delivery of the 3H-BCNU polylacties acid released agents on gliosarcoma]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20030901
Treatment of lymphoma relapses after allogeneic hematopoietic stem cell transplantation with intensive chemotherapy followed by infusion of hematopoietic stem cell from the original donor. Annals of hematology 20030901
Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine. Clinical cancer research : an official journal of the American Association for Cancer Research 20030901
First European case of serotype A MATa Cryptococcus neoformans infection. Emerging infectious diseases 20030901
Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma. Journal of neuro-oncology 20030901
Semichronic inhibition of glutathione reductase promotes oxidative damage to proteins and induces both transcription and translation of tyrosine hydroxylase in the nigrostriatal system. Free radical research 20030901
Ion dependence of cytotoxicity of carmustine against PC12 cells. European journal of pharmacology 20030829
Effect of spermine synthase on the sensitivity of cells to anti-tumour agents. The Biochemical journal 20030801
Testicular plasmacytoma with bone dissemination without medullary plasmacytosis. Annals of hematology 20030801
Cytotoxicity of RH1 and related aziridinylbenzoquinones: involvement of activation by NAD(P)H:quinone oxidoreductase (NQO1) and oxidative stress. Archives of biochemistry and biophysics 20030801
Human-yeast chimeric repair protein protects mammalian cells against alkylating agents: enhancement of MGMT protection. Cancer gene therapy 20030801
A mathematical model for reconstitution of granulopoiesis after high dose chemotherapy with autologous stem cell transplantation. Journal of mathematical biology 20030801
Low hospital mortality in patients with acute interstitial pneumonia. Chest 20030801
Recombinant human erythropoietin, epoetin beta, in patients with relapsed lymphoma treated with aggressive sequential salvage chemotherapy--results of a randomized trial. Annals of hematology 20030801
Summary version of the Standards, Options and Recommendations for the management of adult patients with intracranial glioma (2002). British journal of cancer 20030801
Gliadel for pituitary adenomas and craniopharyngiomas. Neurosurgery 20030801
The value of augmented preparative regimens combined with an autologous bone marrow transplant for the management of relapsed or refractory Hodgkin disease: a Southwest Oncology Group phase II trial. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20030801
Pharmacokinetics of O6-benzylguanine (NSC637037) and its metabolite, 8-oxo-O6-benzylguanine. Journal of clinical pharmacology 20030801
Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients. Journal of hematotherapy & stem cell research 20030801
Gliadel therapy given for first resection of malignant glioma: a single centre study of the potential use of Gliadel. British journal of neurosurgery 20030801
Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells. Cancer research 20030715
Development of resistance to a trinuclear platinum complex in ovarian carcinoma cells. International journal of cancer 20030710
Candidemia in women with breast carcinoma treated with high-dose chemotherapy and autologous bone marrow transplantation. Cancer 20030701
Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients. Molecular therapy : the journal of the American Society of Gene Therapy 20030701
Quality of life evaluation in a randomised trial of chemotherapy versus bio-chemotherapy in advanced melanoma patients. European journal of cancer (Oxford, England : 1990) 20030701
Enhancement of platinum-induced cytotoxicity by O6-benzylguanine. Molecular cancer therapeutics 20030701
BEAC or BEAM for high-dose therapy in patients with non-Hodgkin's lymphoma? A single centre analysis on toxicity and efficacy. Leukemia & lymphoma 20030701
Phase II trial of thalidomide and carmustine for patients with recurrent high-grade gliomas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030615
Myeloid clonogenic assays for comparison of the in vitro toxicity of alkylating agents. Toxicology in vitro : an international journal published in association with BIBRA 20030601
Idiopathic pneumonia syndrome after high-dose chemotherapy and autologous hematopoietic stem cell transplantation for high-risk breast cancer. Bone marrow transplantation 20030601
Non-hodgkins lymphoma. Clinical evidence 20030601
Permeation of cytotoxic formulations through swatches from selected medical gloves. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030515
High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. The New England journal of medicine 20030508
The surgical bed after BCNU polymer wafer placement for recurrent glioma: serial assessment on CT and MR imaging. AJR. American journal of roentgenology 20030501
The emerging role of irinotecan (CPT-11) in the treatment of malignant glioma in brain tumors. Cancer 20030501
Dose escalation of carmustine in surgically implanted polymers in patients with recurrent malignant glioma: a New Approaches to Brain Tumor Therapy CNS Consortium trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030501
Upper lobe pulmonary fibrosis associated with high-dose chemotherapy containing BCNU for bone marrow transplantation. Mayo Clinic proceedings 20030501
Interferon-gamma for delayed pulmonary toxicity syndrome resistant to steroids. Bone marrow transplantation 20030501
Formation of DNA adducts and tumor growth delay following intratumoral administration of DTI-015. Journal of neuro-oncology 20030501
A hybrid form of myeloid/NK-cell acute leukemia and myeloid/NK-cell precursor acute leukemia. Human pathology 20030501
Treatment of relapsing refractory diffuse large cell lymphoma after matched unrelated donor bone marrow transplant with immunosuppression withdrawal and rituximab. Leukemia & lymphoma 20030501
Synthesis and antifilarial evaluation of N1,Nn- xylofuranosylated diaminoalkanes. Bioorganic & medicinal chemistry 20030417
Allogeneic stem-cell transplantation from related and unrelated donors in older patients with myeloid leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030415
Phase III study comparing three cycles of infusional carmustine and cisplatin followed by radiation therapy with radiation therapy and concurrent carmustine in patients with newly diagnosed supratentorial glioblastoma multiforme: Eastern Cooperative Oncology Group Trial 2394. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030415
Salvage treatment with etoposide (VP-16), ifosfamide and cytarabine (Ara-C) for patients with recurrent primary central nervous system lymphoma. European journal of haematology 20030401
Local immunotherapy with interleukin-2 delivered from biodegradable polymer microspheres combined with interstitial chemotherapy: a novel treatment for experimental malignant glioma. Neurosurgery 20030401
A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma. Neuro-oncology 20030401
Preliminary report of a phase I study of combination chemotherapy and humanized A33 antibody immunotherapy in patients with advanced colorectal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20030401
O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme. Clinical cancer research : an official journal of the American Association for Cancer Research 20030401
Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma. Melanoma research 20030401
High-dose BCNU followed by autologous hematopoietic stem cell transplantation in supratentorial high-grade malignant gliomas: a retrospective analysis of 114 patients. Bone marrow transplantation 20030401
Chemotherapy and bio-chemotherapy in patients with advanced melanoma: combination therapy with a nitrosourea. Journal of chemotherapy (Florence, Italy) 20030401
Bexarotene gel: a new skin-directed treatment option for cutaneous T-cell lymphomas. Journal of drugs in dermatology : JDD 20030401
Risk factors for postcraniotomy surgical site infection after 1,3-bis (2-chloroethyl)-1-nitrosourea (Gliadel) wafer placement. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030315
[Bacteremia due to Capnocytophaga spp.: two cases]. Enfermedades infecciosas y microbiologia clinica 20030301
Decreased GSSG reductase activity enhances cellular zinc toxicity in three human lung cell lines. Archives of toxicology 20030301
Camptothecin analogs in malignant gliomas: comparative analysis and characterization. Journal of neurosurgery 20030301
BEAM allogeneic transplantation for patients with Hodgkin's disease who relapse after autologous transplantation is safe and effective. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20030301
High-dose cyclophosphamide, BCNU, and VP-16 (CBV) conditioning before allogeneic stem cell transplantation for patients with non-Hodgkin's lymphoma. Bone marrow transplantation 20030301
[Evidence-based radiation therapy for primary brain tumors]. Gan to kagaku ryoho. Cancer & chemotherapy 20030301
Stress-responsive JNK mitogen-activated protein kinase mediates aspirin-induced suppression of B16 melanoma cellular proliferation. British journal of pharmacology 20030301
Oxidative modulation of the glutathione-redox couple enhances lipopolysaccharide-induced interleukin 12 P40 production by a mouse macrophage cell line, J774A.1. Free radical research 20030301
Survival with dacarbazine and fotemustine in newly diagnosed glioblastoma multiforme. British journal of cancer 20030224
Pharmacokinetic, biochemical and clinical effects of dimethyltriazenoimidazole-4-carboxamide-bischloroethylnitrosourea combination therapy in patients with advanced breast cancer. International journal of cancer 20030220
Factors influencing outcome and incidence of long-term complications in children who underwent autologous stem cell transplantation for acute myeloid leukemia in first complete remission. Blood 20030215
Temozolomide induces apoptosis and senescence in glioma cells cultured as multicellular spheroids. British journal of cancer 20030210
The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin. The Journal of pharmacology and experimental therapeutics 20030201
Inhibition of oral cancer cell growth by adenovirusMnSOD plus BCNU treatment. Free radical biology & medicine 20030201
Low molecular weight heparin treatment for malignant melanoma: a pilot clinical trial. Thrombosis and haemostasis 20030201
[Foliculitis in a patient with Hodkins disease]. Enfermedades infecciosas y microbiologia clinica 20030201
High-dose chemotherapy with autologous stem cell rescue in children with retinoblastoma. Bone marrow transplantation 20030201
Synchronous occurrence of glioblastoma multiforme and esophageal adenocarcinoma. The American surgeon 20030201
MRP1-transfected cells do not show increased resistance against oxidative stress. Free radical research 20030201
Potentiation of chemotherapeutic agents following antagonism of nuclear factor kappa B in human gliomas. Journal of neuro-oncology 20030201
BCNU-loaded poly(D, L-lactide-co-glycolide) wafer and antitumor activity against XF-498 human CNS tumor cells in vitro. International journal of pharmaceutics 20030130
Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress. Brain research 20030117
SarCNU, a nitrosourea analog on a day 1, 5, and 9 oral schedule: a phase I and pharmacokinetic study in patients with advanced solid tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030115
High-dose therapy in diffuse large cell lymphoma: results and prognostic factors in 452 patients from the GEL-TAMO Spanish Cooperative Group. Annals of oncology : official journal of the European Society for Medical Oncology 20030101
Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor. Molecular pharmacology 20030101
Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitor. Journal of neurosurgery 20030101
[The role of the regional (intra-arterial) chemotherapy in the treatment of hepatic metastases of colorectal cancer]. Medicina (Kaunas, Lithuania) 20030101
Stereotactic injection of DTI-015 into recurrent malignant gliomas: phase I/II trial. Neoplasia (New York, N.Y.) 20030101
DTI-015 produces cures in T9 gliosarcoma. Neoplasia (New York, N.Y.) 20030101
[Effectiveness of dose-intensive polychemotherapy with autologous hemopoietic cell transplantation for high-grade non-Hodgkin lymphoma]. Voprosy onkologii 20030101
SarCNU mediates selection of P140K methylguanine-DNA-methyltransferase transduced human CD34(+) cells in vitro. Blood cells, molecules & diseases 20030101
[Chemotherapy in combination with laser coagulation or interstitial hyperthermia--effective combined therapy for disseminated skin melanoma]. Voprosy onkologii 20030101
Current chemotherapy for glioblastoma. Cancer journal (Sudbury, Mass.) 20030101
Intracavitary chemotherapy for glioblastoma: present status and future directions. Acta neurochirurgica. Supplement 20030101
High-dose therapy and autologous stem cell transplantation in relapsed and refractory Hodgkin's disease: outcome based on a prognostic model. Acta haematologica 20030101
Topical carmustine (BCNU) in the treatment of mycosis fungoides. Dermatologic therapy 20030101
New drugs and combinations for malignant glioma. Forum (Genoa, Italy) 20030101
Regulation of intracellular glutathione levels in erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum. The Biochemical journal 20021215
Chemoresistant or aggressive lymphoma predicts for a poor outcome following reduced-intensity allogeneic progenitor cell transplantation: an analysis from the Lymphoma Working Party of the European Group for Blood and Bone Marrow Transplantation. Blood 20021215
Stabilization and preformulation of anticancer drug--SarCNU. International journal of pharmaceutics 20021205
Recurrent malignant glioma in adults. Current treatment options in oncology 20021201
Pulmonary complications in survivors of childhood and adolescent cancer. A report from the Childhood Cancer Survivor Study. Cancer 20021201
1-beta-D-arabinofuranosylcytosine is cytotoxic in quiescent normal lymphocytes undergoing DNA excision repair. Japanese journal of cancer research : Gann 20021201
Intra-arterial ACNU and carboplatin versus intravenous chemotherapy with cisplatin and BCNU in newly diagnosed patients with glioblastoma. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20021201
Randomized study to evaluate the use of high-dose therapy as part of primary treatment for 'aggressive' lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20021115
The toxicity and efficacy of donor lymphocyte infusions given after reduced-intensity conditioning allogeneic stem cell transplantation. Blood 20021101
Vanishing corneal epithelial crystals following thalidomide induced resolution of myeloma related paraproteinaemia. The British journal of ophthalmology 20021101
Toxicity of intracranial and intraperitoneal O6-benzyl guanine in combination with BCNU delivered locally in a mouse model. Cancer chemotherapy and pharmacology 20021101
Alkylator-induced DNA excision repair in human leukemia CCRF-CEM cells in vitro, measured using the single-cell gel electrophoresis (comet) assay. International journal of hematology 20021101
Development of an in vitro chemo-radiation response assay for cervical carcinoma. Gynecologic oncology 20021101
Treatment of paediatric pontine glioma with oral trophosphamide and etoposide. British journal of cancer 20021021
Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanism. Circulation research 20021018
Gliomatosis cerebri: molecular pathology and clinical course. Annals of neurology 20021001
Chemoimmunohormonal therapy with carmustine, dacarbazine, cisplatin, tamoxifen, and interferon for metastatic melanoma: a prospective phase II study. American journal of clinical oncology 20021001
Inhibition of O6-alkylguanine-DNA alkyltransferase by O6-benzyl-N2-acetylguanosine increases chloroethylnitrosourea-induced apoptosis in Mer+ human melanoma cells. Melanoma research 20021001
Allogeneic stem cell transplantation in treatment of aggressive lymphomas: case series. Croatian medical journal 20021001
Systemic chemotherapy for the treatment of metastatic melanoma. Seminars in oncology 20021001
Inhibition of glutathione-related enzymes augments LPS-mediated cytokine biosynthesis: involvement of an IkappaB/NF-kappaB-sensitive pathway in the alveolar epithelium. International immunopharmacology 20021001
Chemosensitization of carmustine with maitake beta-glucan on androgen-independent prostatic cancer cells: involvement of glyoxalase I. Journal of alternative and complementary medicine (New York, N.Y.) 20021001
Accumulation of glutathione disulfide mediates NF-kappaB activation during immune stimulation with CpG DNA. Antisense & nucleic acid drug development 20021001
[Experimental study of combination therapy against human glioma xenograft by differentiation-inducing agent and cytotoxic chemotherapeutic drug]. Ai zheng = Aizheng = Chinese journal of cancer 20021001
Phase I study of fotemustine in pediatric patients with refractory brain tumors. Cancer 20020915
Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex. Epilepsia 20020901
Long-term results (12 years) of high-dose therapy in 127 patients with de novo multiple myeloma. Leukemia 20020901
In vitro and in vivo characterization of graft-versus-tumor responses in melanoma patients after allogeneic peripheral blood stem cell transplantation. International journal of cancer 20020901
The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress. Clinical cancer research : an official journal of the American Association for Cancer Research 20020901
O6-benzylguanine-mediated enhancement of chemotherapy. Molecular cancer therapeutics 20020901
Goosebumps. Lancet (London, England) 20020831
Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen. American journal of physiology. Lung cellular and molecular physiology 20020801
The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner. Cancer research 20020801
A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma. Journal of Korean medical science 20020801
The Brain Tumor Cooperative Group NIH Trial 87-01: a randomized comparison of surgery, external radiotherapy, and carmustine versus surgery, interstitial radiotherapy boost, external radiation therapy, and carmustine. Neurosurgery 20020801
Induced leukemia and antineoplastic agent carmustine cause permanent changes in craniofacial growth of immature rats. Orthodontics & craniofacial research 20020801
Acute myocardial ischemia after high-dose therapy with BEAM regimen. Bone marrow transplantation 20020801
Evaluation of the efficiency of chemotherapy in in vivo orthotopic models of human glioma cells with and without 1p19q deletions and in C6 rat orthotopic allografts serving for the evaluation of surgery combined with chemotherapy. Cancer 20020801
A randomized trial of chemotherapy with carmustine, etoposide, cytarabine, and melphalan (BEAM) plus peripheral stem cell transplantation (PBSCT) vs single-agent high-dose chemotherapy followed by BEAM plus PBSCT in patients with relapsed Hodgkin's disease (HD-R2). Annals of hematology 20020801
Alkylation resistance of E. coli cells expressing different isoforms of human alkyladenine DNA glycosylase (hAAG). DNA repair 20020717
Novel mutation of topoisomerase I in rendering cells resistant to camptothecin. Cancer research 20020701
Unusual implantation site of a port-a-cath system via the right femoral vein. Journal of cancer research and clinical oncology 20020701
Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma. Molecular cancer therapeutics 20020701
A multidrug combination designed for reversing resistance to BCNU in glioblastoma multiforme. Neurology 20020625
Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. Lancet (London, England) 20020615
Heterogeneity of O6-alkylguanine DNA-alkyltransferase expression in human breast tumours. British journal of cancer 20020605
Safety of thrice-daily hyperfractionated radiation and BCNU for high-grade gliomas. International journal of radiation oncology, biology, physics 20020601
Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer. Cancer research 20020601
Composite mycosis fungoides and B-cell chronic lymphocytic leukemia. Annals of diagnostic pathology 20020601
Association of carmustine with a lipid emulsion: in vitro, in vivo and preliminary studies in cancer patients. Cancer chemotherapy and pharmacology 20020601
Successful therapy with high-dose steroids and cyclosporine for the treatment of carmustine-mediated lung injury. Annals of hematology 20020601
Predictors for pneumonitis during locoregional radiotherapy in high-risk patients with breast carcinoma treated with high-dose chemotherapy and stem-cell rescue. Cancer 20020601
[Primary cardiac lymphoma: cytological diagnosis and treatment with response to polychemotherapy and hematopoietic precursor autotransplant. Presentation of a case a review of the literature]. Anales de medicina interna (Madrid, Spain : 1984) 20020601
Autologous stem cell transplantation in patients with mantle cell lymphoma. Leukemia & lymphoma 20020601
Efficacy of BCNU and paclitaxel loaded subcutaneous implants in the interstitial chemotherapy of U-87 MG human glioblastoma xenografts. International journal of pharmaceutics 20020515
Shortened first-line high-dose chemotherapy for patients with poor-prognosis aggressive lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020515
Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020501
Autologous transplantation for aggressive non-Hodgkin's lymphoma: results of a randomized trial evaluating graft source and minimal residual disease. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020501
Clinical relevance of MGMT in the treatment of cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020501
Management of tumor bed cysts after chemotherapeutic wafer implantation. Report of four cases. Journal of neurosurgery 20020501
A major human arsenic metabolite, dimethylarsinic acid, requires reduced glutathione to induce apoptosis. Chemical research in toxicology 20020501
Factors affecting progression-free survival in hormone-dependent metastatic breast cancer patients receiving high-dose chemotherapy and hematopoietic progenitor cell transplantation: role of maintenance endocrine therapy. Bone marrow transplantation 20020501
NO-mediated chemoresistance in C6 glioma cells. Annals of the New York Academy of Sciences 20020501
Synergistic effect of genistein and BCNU on growth inhibition and cytotoxicity of glioblastoma cells. Journal of neuro-oncology 20020501
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Phase II study of irinotecan (CPT-11) in children with high-risk malignant brain tumors: the Duke experience. Neuro-oncology 20020401
Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro. Molecular therapy : the journal of the American Society of Gene Therapy 20020401
In vitro pharmacokinetics and pharmacodynamics of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Biochemical pharmacology 20020401
Antiproliferative effect of thalidomide alone and combined with carmustine against C6 rat glioma. International journal of experimental pathology 20020401
Gateways to Clinical Trials. Methods and findings in experimental and clinical pharmacology 20020401
Autologous stem cell transplantation for Hodgkin's lymphoma: results and prognostic factors in 51 high-risk patients. Advances in clinical pathology : the official journal of Adriatic Society of Pathology 20020401
Cisplatin, dacarbazine with or without subcutaneous interleukin-2, and interferon alpha-2b in advanced melanoma outpatients: results from an Italian multicenter phase III randomized clinical trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020315
A phase II trial of the vitamin D analogue Seocalcitol (EB1089) in patients with inoperable pancreatic cancer. British journal of cancer 20020304
Improvement of combination chemotherapy tolerance by introduction of polycistronic retroviral vector drug resistance genes MGMT and MDR1 into human umbilical cord blood CD34+ cells. Leukemia research 20020301
The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis. European journal of biochemistry 20020301
Association of high-dose cyclophosphamide, cisplatin, and carmustine pharmacokinetics with survival, toxicity, and dosing weight in patients with primary breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20020301
Widespread skin-limited adult Langerhans cell histiocytosis: long-term follow-up with good response to interferon alpha. Clinical and experimental dermatology 20020301
Apoptosis induced by adenovirus-mediated p53 gene transfer in human glioma correlates with site-specific phosphorylation. Cancer research 20020215
Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. International journal of cancer 20020210
Comparison of the efficacy of two different dosage dacarbazine-based regimens and two regimens without dacarbazine in metastatic melanoma: a single-centre randomized four-arm study. Melanoma research 20020201
Positron emission tomography with [18F]2-fluoro-D-2-deoxyglucose (FDG-PET) predicts relapse of malignant lymphoma after high-dose therapy with stem cell transplantation. Leukemia 20020201
Point mutations of the BCL-6 gene: clinical and prognostic correlation in B-diffuse large cell lymphoma. Leukemia 20020201
Thromboxane synthase inhibitors induce apoptosis in migration-arrested glioma cells. Neurosurgery 20020201
Influence of antioxidant depletion on nitrergic relaxation in the pig gastric fundus. British journal of pharmacology 20020201
Redox signaling-mediated regulation of lipopolysaccharide-induced proinflammatory cytokine biosynthesis in alveolar epithelial cells. Antioxidants & redox signaling 20020201
Polymer delivery of camptothecin against 9L gliosarcoma: release, distribution, and efficacy. Journal of neuro-oncology 20020201
Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. Oncogene 20020131
Combination chemotherapy with or without s.c. IL-2 and IFN-alpha: results of a prospectively randomized trial of the Cooperative Advanced Malignant Melanoma Chemoimmunotherapy Group (ACIMM). British journal of cancer 20020121
[Chemotherapy of recurrent supratentorial malignant gliomas (phase II study)]. Ideggyogyaszati szemle 20020120
Intensive salvage therapy with high-dose chemotherapy for patients with advanced Hodgkin's disease in relapse or failure after initial chemotherapy: results of the Groupe d'Etudes des Lymphomes de l'Adulte H89 Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020115
The polymorphic human glutathione transferase T1-1, the most efficient glutathione transferase in the denitrosation and inactivation of the anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea. Biochemical pharmacology 20020115
Escherichia coli FPG and human OGG1 reduce DNA damage and cytotoxicity by BCNU in human lung cells. American journal of physiology. Lung cellular and molecular physiology 20020101
Up-regulation of K(+) channels in diabetic rat ventricular myocytes by insulin and glutathione. Cardiovascular research 20020101
Importance of radiotherapy in the outcome of patients with primary CNS lymphoma: an analysis of the CHOD/BVAM regimen followed by two different radiotherapy treatments. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020101
Age-adjusted chemotherapy for primary central-nervous system lymphoma--a pilot study. Acta oncologica (Stockholm, Sweden) 20020101
Comparative cytotoxicity of carmustine (BCNU), nimustine (ACNU) and elmustine (HeCNU) after depletion of O6-alkylguanine-DNA alkyltransferase (O6-AGT). Anticancer research 20020101
Pharmacokinetics of the carmustine implant. Clinical pharmacokinetics 20020101
Injection of chemotherapeutic microspheres and glioma. IV: Eradicating tumors in rats. Cell transplantation 20020101
Dose-intensive therapy for extensive-stage small cell lung cancer and extrapulmonary small cell carcinoma: long-term outcome. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20020101
Ambulatory electrocardiographic evaluation of the heart in patients treated by megachemotherapy and bone marrow transplantation. Haematologia 20020101
Temozolomide in second-line treatment after prior nitrosurea-based chemotherapy in glioblastoma multiforme: experience from a Portuguese institution. International journal of clinical pharmacology research 20020101
Use of thrombopoietin in combination with chemotherapy and granulocyte colony-stimulating factor for peripheral blood progenitor cell mobilization. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20020101
Cytotoxicity of natural hydroxyanthraquinones: role of oxidative stress. Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101
[High-dose chemotherapy with autologous bone marrow transplantation in children with high-risk malignant neoformations]. Voprosy onkologii 20020101
BCNU-DBD (Dibromodulcitol) chemotherapy of recurrent supratentorial anaplastic astrocytomas and glioblastomas. Neoplasma 20020101
Pharmacological considerations of primary alkylators. Cancer treatment and research 20020101
High-dose chemotherapy and hematopoietic support for patients with high-risk primary breast cancer and involvement of 4 to 9 lymph nodes. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20020101
[Effectiveness of high-dose polychemotherapy and autologous hemopoietic cell transplantation in patients with low-grade non-Hodgkin lymphoma]. Voprosy onkologii 20020101
Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology. Respiratory research 20020101
High-dose chemotherapy in small-cell lung cancer. Anticancer research 20020101
bis(Chloroethyl) nitrosourea. Report on carcinogens : carcinogen profiles 20020101
Induction of lacI mutations in Big Blue Rat-2 cells treated with 1-(2-hydroxyethyl)-1-nitrosourea: a model system for the analysis of mutagenic potential of the hydroxyethyl adducts produced by 1,3-bis (2-chloroethyl)-1-nitrosourea. Mutation research 20011212
HER-2/neu overexpression as a poor prognostic factor for patients with metastatic breast cancer undergoing high-dose chemotherapy with autologous stem cell transplantation. Clinical cancer research : an official journal of the American Association for Cancer Research 20011201
Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation. Clinical cancer research : an official journal of the American Association for Cancer Research 20011201
High-dose chemotherapy and CD34-selected peripheral blood progenitor cell transplantation for patients with breast cancer metastatic to bone and/or bone marrow. Bone marrow transplantation 20011201
Tandem autotransplant as first-line consolidative treatment in poor-risk aggressive lymphoma: a pilot study of 36 patients. Annals of oncology : official journal of the European Society for Medical Oncology 20011201
Thoracic positron emission tomography using 18F-fluorodeoxyglucose for the evaluation of residual mediastinal Hodgkin disease. Blood 20011115
High-dose therapy in patients with Hodgkin's disease: the use of selected CD34(+) cells is as safe as unmanipulated peripheral blood progenitor cells. Bone marrow transplantation 20011101
A novel type of metastatically spreading subcutaneous aspergillosis without epidermal lesions following allogeneic stem cell transplantation. Bone marrow transplantation 20011101
The effectiveness of the O(6)-alkylguanine-DNA alkyltransferase encoded by the ogt(ST) gene from S. typhimurium in protection against alkylating drugs, resistance to O(6)-benzylguanine and sensitisation to dibromoalkane genotoxicity. Mutation research 20011018
Quinacrine enhances carmustine therapy of experimental rat glioma. Neurosurgery 20011001
Levels of N7-(2-hydroxyethyl)guanine as a molecular dosimeter of drug delivery to human brain tumors. Neuro-oncology 20011001
Phase I study of Gliadel wafers plus temozolomide in adults with recurrent supratentorial high-grade gliomas. Neuro-oncology 20011001
Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation. Clinical cancer research : an official journal of the American Association for Cancer Research 20011001
Induction of mild intracellular redox imbalance inhibits proliferation of CaCo-2 cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011001
Considerations in the selection of an appropriate conditioning regimen for the treatment of rheumatoid arthritis by autologous peripheral blood stem cell transplantation. The Journal of rheumatology. Supplement 20011001
G156A MGMT-transduced human mesenchymal stem cells can be selectively enriched by O6-benzylguanine and BCNU. Journal of hematotherapy & stem cell research 20011001
Outcome and long-term side effects after synchronous radiochemotherapy for childhood brain stem gliomas. Pediatric neurosurgery 20011001
Immunomodulation of early engrafted natural killer cells with interleukin-2 and interferon-alpha in autologous stem cell transplantation. Bone marrow transplantation 20011001
Use of pure t-butanol as a solvent for freeze-drying: a case study. International journal of pharmaceutics 20010911
Nitric oxide and free stable nitroxyl radicals in the mechanism of biological action of the spin-labeled compounds. Medical hypotheses 20010901
Accelerated hazards regression model and its adequacy for censored survival data. Biometrics 20010901
T-cell depletion and autologous stem cell transplantation in the management of tumour stage mycosis fungoides with peripheral blood involvement. British journal of haematology 20010901
Plasma pharmacokinetics and bioavailability of 1-(2-chloroethyl)-3-sarcosinamide-1-nitrosourea after intravenous and oral administration to mice and dogs. Cancer chemotherapy and pharmacology 20010901
[Role of high-dose chemotherapy with hemopoietic stem-cell support in the treatment of adult patients with high-grade glioma]. Bulletin du cancer 20010901
[Autograft and multiple myeloma: experience of the Intergroupe Français du Myélome]. Bulletin du cancer 20010901
[Expression and drug resistance of human MGMT gene in hemopoietic cells mediated by bicistronic retroviral vector]. Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20010901
[A bicistronic retroviral vector containing MGMT and MDR1 drug resistance genes transfer into human umbilical cord blood CD34+ cells to improve combination chemotherapy tolerance]. Shi yan sheng wu xue bao 20010901
Adenovirally-mediated transfer of E2F-1 potentiates chemosensitivity of human glioma cells to temozolomide and BCNU. International journal of oncology 20010801
Temozolomide in combination with other cytotoxic agents. Seminars in oncology 20010801
Pulmonary toxicity syndrome following CDEP (cyclophosphamide, dexamethasone, etoposide, cisplatin) chemotherapy. Bone marrow transplantation 20010801
Bcl-2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity. Journal of cellular biochemistry 20010801
Diaminopurine-acridine heterodimers for specific recognition of abasic site containing DNA. Influence on the biological activity of the position of the linker on the purine ring. Bioorganic & medicinal chemistry letters 20010723
A phase III study of radiation therapy plus carmustine with or without recombinant interferon-alpha in the treatment of patients with newly diagnosed high-grade glioma. Cancer 20010715
Autologous hematopoietic stem cell transplantation suppresses Gd-enhanced MRI activity in MS. Neurology 20010710
Biodegradable polymer implants to treat brain tumors. Journal of controlled release : official journal of the Controlled Release Society 20010706
Modulation of 1,3-bis-(2-chloroethyl)-1-nitrosourea resistance in human tumor cells using hammerhead ribozymes designed to degrade O6-methylguanine DNA methyltransferase mRNA. The Journal of pharmacology and experimental therapeutics 20010701
Potentiation of BCNU cytotoxicity by molecules targeting abasic lesions in DNA. Bioorganic & medicinal chemistry 20010701
A CD44 survival pathway triggers chemoresistance via lyn kinase and phosphoinositide 3-kinase/Akt in colon carcinoma cells. Cancer research 20010701
Acyl derivatives of demethylpenclomedine, an antitumor-active, non-neurotoxic metabolites of penclomedine. Cancer chemotherapy and pharmacology 20010701
Dexamethasone, paclitaxel, etoposide, cyclophosphamide (d-TEC) and G-CSF for stem cell mobilisation in multiple myeloma. Bone marrow transplantation 20010701
Autologous stem cell transplantation for follicular lymphoma: no benefit for early transplant? Annals of hematology 20010701
Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones. European journal of haematology 20010701
Amifostine does not protect malignant lymphoma cell lines from the cytotoxic effects of various chemotherapeutics in vitro. Leukemia & lymphoma 20010701
Heterogeneous methylation of the O(6)-methylguanine-DNA methyltransferase promoter in immortalized IMR90 cell lines. International journal of oncology 20010601
CHOD/BVAM regimen plus radiotherapy in patients with primary CNS non-Hodgkin's lymphoma. International journal of radiation oncology, biology, physics 20010601
Daunorubicin continuous infusion induces more toxicity than bolus infusion in acute lymphoblastic leukemia induction regimen: a randomized study. Leukemia 20010601
Anticancer therapy by overexpression of superoxide dismutase. Antioxidants & redox signaling 20010601
Metastatic melanoma. Current treatment options in oncology 20010601
Design, synthesis, and biological evaluation of analogues of the antitumor agent, 2-(4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469). Journal of medicinal chemistry 20010524
Synergy between methionine stress and chemotherapy in the treatment of brain tumor xenografts in athymic mice. Cancer research 20010515
Inactivation of p53 sensitizes U87MG glioma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer research 20010515
Comparison of single- versus double-bolus treatments of O(6)-benzylguanine for depletion of O(6)-methylguanine DNA methyltransferase (MGMT) activity in vivo: development of a novel fluorometric oligonucleotide assay for measurement of MGMT activity. The Journal of pharmacology and experimental therapeutics 20010501
Cellular titration of apoptosis with steady state concentrations of H(2)O(2): submicromolar levels of H(2)O(2) induce apoptosis through Fenton chemistry independent of the cellular thiol state. Free radical biology & medicine 20010501
Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents. Clinical cancer research : an official journal of the American Association for Cancer Research 20010501
O6-Benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells. Experimental hematology 20010501
Immunoablative therapy with autologous stem cell transplantation in the treatment of poor risk multiple sclerosis. Transplantation proceedings 20010501
Shunt-related abdominal metastases in an infant with medulloblastoma: long-term remission by systemic chemotherapy and surgery. Journal of neuro-oncology 20010501
Drug delivery to tumors of the central nervous system. Current neurology and neuroscience reports 20010501
The role of glutathione reductase in the cytotoxicity of chromium (VI) in isolated rat hepatocytes. Chemico-biological interactions 20010416
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