200,000+ products from a single source!

sales@angenechem.com

Home > Fluorides > 152121-53-4

152121-53-4

152121-53-4 | 4-(4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl)pyridine

CAS No: 152121-53-4 Catalog No: AG003K1M MDL No:MFCD12405019

Product Description

Catalog Number:
AG003K1M
Chemical Name:
4-(4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl)pyridine
CAS Number:
152121-53-4
Molecular Formula:
C20H13FN4O2
Molecular Weight:
360.3412
MDL Number:
MFCD12405019
IUPAC Name:
4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine
InChI:
InChI=1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
InChI Key:
BGIYKDUASORTBB-UHFFFAOYSA-N
SMILES:
Fc1ccc(cc1)c1nc([nH]c1c1ccncc1)c1ccc(cc1)[N+](=O)[O-]
UNII:
GX3Y2V80CV

Properties

Complexity:
495  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
360.102g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
360.348g/mol
Monoisotopic Mass:
360.102g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
87.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.9  

Literature

Title Journal
A Role for p38 Mitogen-activated Protein Kinase-mediated Threonine 30-dependent Norepinephrine Transporter Regulation in Cocaine Sensitization and Conditioned Place Preference. The Journal of biological chemistry 20150424
Quinoline compound KM11073 enhances BMP-2-dependent osteogenic differentiation of C2C12 cells via activation of p38 signaling and exhibits in vivo bone forming activity. PloS one 20150101
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. The Biochemical journal 20130415
p38 Mitogen-activated protein kinase modulates exocrine secretion in rabbit lacrimal gland. Cellular & molecular biology letters 20120301
Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling. The Journal of biological chemistry 20120217
Translocation and oligomerization of Bax is regulated independently by activation of p38 MAPK and caspase-2 during MN9D dopaminergic neurodegeneration. Apoptosis : an international journal on programmed cell death 20111101
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nature biotechnology 20111101
Cocaine up-regulation of the norepinephrine transporter requires threonine 30 phosphorylation by p38 mitogen-activated protein kinase. The Journal of biological chemistry 20110610
[The role of serine/threonine and tyrosine protein kinases in the depression of cholinosensitivity in Helix lucorum neurons in the cellular correlate of habituation]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20110101
High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-α. Journal of nutritional science and vitaminology 20110101
Differentiation and neural integration of hippocampal neuronal progenitors: signaling pathways sequentially involved. Hippocampus 20100801
ES936 stimulates DNA synthesis in HeLa cells independently on NAD(P)H:quinone oxidoreductase 1 inhibition, through a mechanism involving p38 MAPK. Chemico-biological interactions 20100730
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology 20091001
Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression. American journal of physiology. Cell physiology 20090901
Role PKA and p38 MAPK on ROS production in neutrophil age-related: Lack of IL-10 effect in older subjects. Mechanisms of ageing and development 20090901
Endotoxin-induced activation of equine digital vein endothelial cells: role of p38 MAPK. Veterinary immunology and immunopathology 20090615
15-Deoxy-Delta-Prostaglandin J(2) Upregulates the Expression of LPS-Induced IL-8/CXCL8 mRNA in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats. Immune network 20090401
Heparin binding epidermal growth factor-like growth factor and PD169316 prevent apoptosis in mouse embryonic stem cells. Journal of biochemistry 20090201
The role of p38 MAPK and JNK in Arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells. Journal of cellular physiology 20081001
Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature chemical biology 20080501
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proceedings of the National Academy of Sciences of the United States of America 20071218
p38MAP Kinase activity is required for human primary adipocyte differentiation. FEBS letters 20071211
Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells. Biochimica et biophysica acta 20071201
P2Y2 nucleotide receptors inhibit trauma-induced death of astrocytic cells. Journal of neurochemistry 20071201
Myocardial ischemia/reperfusion causes VDAC phosphorylation which is reduced by cardioprotection with a p38 MAP kinase inhibitor. Proteomics 20071201
Mixed lineage kinase 3 connects reactive oxygen species to c-Jun NH2-terminal kinase-induced mitochondrial apoptosis in genipin-treated PC3 human prostate cancer cells. Biochemical and biophysical research communications 20071019
Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism. The Biochemical journal 20070715
Endotoxin-induced activation of equine platelets: evidence for direct activation of p38 MAPK pathways and vasoactive mediator production. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20070401
Bone morphogenetic protein-4 abrogates lumen formation by mammary epithelial cells and promotes invasive growth. Biochemical and biophysical research communications 20070216
Intrinsically active variants of all human p38 isoforms. The FEBS journal 20070201
Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070101
Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily. Prostaglandins, leukotrienes, and essential fatty acids 20060801
N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells. Oncogene 20060504
p38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis. Stem cells (Dayton, Ohio) 20060501
HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways. Journal of leukocyte biology 20051001
Anisomycin induces COX-2 mRNA expression through p38(MAPK) and CREB independent of small GTPases in intestinal epithelial cells. Biochimica et biophysica acta 20050930
Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation. Molecular biology of the cell 20050901
Midazolam suppresses thrombin-induced heat shock protein 27 phosphorylation through inhibition of p38 mitogen-activated protein kinase in cardiac myocytes. Journal of cellular biochemistry 20050901
Akt regulates thrombin-induced HSP27 phosphorylation in aortic smooth muscle cells: function at a point downstream from p38 MAP kinase. Life sciences 20050520
Kinetic studies of small molecule interactions with protein kinases using biosensor technology. Analytical biochemistry 20050515
Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites. Chemico-biological interactions 20050115
A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050105
p38alpha, but not p38beta, inhibits the phosphorylation and presence of c-FLIPS in DISC to potentiate Fas-mediated caspase-8 activation and type I apoptotic signaling. Journal of cell science 20041215
Effects of inhibitors of the tyrosine signalling cascade on antigen challenge of guinea pig airways in vitro. Annals of the Academy of Medicine, Singapore 20040901
Vasopressin phosphorylates HSP27 in aortic smooth muscle cells. Journal of cellular biochemistry 20040815
Inhibitor of p42/44 mitogen-activated protein kinase, but not p38 MAPK, attenuated antigen challenge of guinea pig airways in vitro. International immunopharmacology 20040801
Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons. The Journal of biological chemistry 20040507
Interleukin (IL)-17 enhances tumor necrosis factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts. Journal of cellular biochemistry 20040401
A p38 inhibitor allows to dissociate differentiation and apoptotic processes triggered upon LIF withdrawal in mouse embryonic stem cells. Cell death and differentiation 20040301
All-trans retinoic acid potentiates Taxotere-induced cell death mediated by Jun N-terminal kinase in breast cancer cells. Oncogene 20040115
Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells. The Journal of biological chemistry 20031226
The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochemical and biophysical research communications 20031017
Inhibition of p38 mitogen-activated protein kinase interferes with cell shape changes and gene expression associated with Schwann cell myelination. Experimental neurology 20030901
Association of mitochondrial calpain activation with increased expression and autolysis of calpain small subunit in an early stage of apoptosis. International journal of molecular medicine 20030801
Mechanism of simvastatin on induction of heat shock protein in osteoblasts. Archives of biochemistry and biophysics 20030701
Involvement of MAP kinases in TGF-beta-stimulated vascular endothelial growth factor synthesis in osteoblasts. Archives of biochemistry and biophysics 20030701
Stimulation of glucose uptake by chronic vanadate pretreatment in cardiomyocytes requires PI 3-kinase and p38 MAPK activation. American journal of physiology. Endocrinology and metabolism 20030601
Involvement of p38 mitogen-activated protein kinase in heat shock protein 27 induction in human neutrophils. European journal of pharmacology 20030418
Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts. The Journal of biological chemistry 20030411
Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes. The Journal of biological chemistry 20030103
Insulin-like growth factor-1-mediated AKT activation postpones the onset of ultraviolet B-induced apoptosis, providing more time for cyclobutane thymine dimer removal in primary human keratinocytes. The Journal of biological chemistry 20020906
Thrombin stimulates dissociation and induction of HSP27 via p38 MAPK in vascular smooth muscle cells. American journal of physiology. Heart and circulatory physiology 20020901
Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications. Blood 20020601
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. The Journal of biological chemistry 20020412
Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation. The Journal of biological chemistry 20020315
Upregulation by retinoic acid of transforming growth factor-beta-stimulated heat shock protein 27 induction in osteoblasts: involvement of mitogen-activated protein kinases. Biochimica et biophysica acta 20020213
1,25-dihydroxyvitamin D3 stimulates vascular endothelial growth factor release in aortic smooth muscle cells: role of p38 mitogen-activated protein kinase. Archives of biochemistry and biophysics 20020201
p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells. Neurobiology of disease 20020201
Retinoid-related molecules induce cytochrome c release and apoptosis through activation of c-Jun NH(2)-terminal kinase/p38 mitogen-activated protein kinases. Cancer research 20011201
Effects of homocysteine on murine splenic B lymphocyte proliferation and its signal transduction mechanism. Cardiovascular research 20011101
Human keratinocytes respond to osmotic stress by p38 map kinase regulated induction of HSP70 and HSP27. The Journal of investigative dermatology 20011101
Antidepressant drug treatments induce glial cell line-derived neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells. Journal of neurochemistry 20011001
Overexpression of calbindin-D28K induces neurite outgrowth in dopaminergic neuronal cells via activation of p38 MAPK. Biochemical and biophysical research communications 20010928
Inhibitors of p38 MAP kinase increase the survival of transplanted dopamine neurons. Brain research 20010209
MEK and p38MAPK inhibitors potentiate TNF-alpha induced apoptosis in U937 cells. Anticancer research 20010101
Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27. Cell stress & chaperones 20010101
Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons. Cellular & molecular biology letters 20010101
p38 mitogen-activated protein kinase regulates a novel, caspase-independent pathway for the mitochondrial cytochrome c release in ultraviolet B radiation-induced apoptosis. The Journal of biological chemistry 20000714
Synergetic activation of p38 mitogen-activated protein kinase and caspase-3-like proteases for execution of calyculin A-induced apoptosis but not N-methyl-d-aspartate-induced necrosis in mouse cortical neurons. Journal of neurochemistry 20000601

© 2019 Angene International Limited. All rights Reserved.