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152028-96-1 | iodoproxyfan
CAS No: 152028-96-1 Catalog No: AG00B3PI MDL No:
Product Description
Catalog Number:
AG00B3PI
Chemical Name:
iodoproxyfan
CAS Number:
152028-96-1
IUPAC Name:
5-[3-[(4-iodophenyl)methoxy]propyl]-1H-imidazole
InChI:
InChI=1S/C13H15IN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16)
InChI Key:
DCQNAFOCXVCDLB-UHFFFAOYSA-N
Properties
Complexity:
208
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
342.023g/mol
Formal Charge:
0
Heavy Atom Count:
17
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
342.18g/mol
Monoisotopic Mass:
342.023g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
37.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7
Literature
| Title | Journal |
|---|---|
| The histamine autoreceptor is a short isoform of the H₃ receptor. | British journal of pharmacology 20120701 |
| Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies. | Journal of medicinal chemistry 20111208 |
| Histamine H4 receptor agonists. | Bioorganic & medicinal chemistry letters 20101215 |
| Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo. | The Journal of pharmacology and experimental therapeutics 20100901 |
| BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. | The Journal of pharmacology and experimental therapeutics 20070101 |
| Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. | British journal of pharmacology 20060401 |
| Generation of cell lines for drug discovery through random activation of gene expression: application to the human histamine H3 receptor. | Assay and drug development technologies 20050601 |
| Search for histamine H3 receptor antagonists with combined inhibitory potency at Ntau-methyltransferase: ether derivatives. | Die Pharmazie 20050201 |
| Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms. | Journal of neurochemistry 20040901 |
| Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain. | Journal of medicinal chemistry 20040603 |
| Characteristics of recombinantly expressed rat and human histamine H3 receptors. | European journal of pharmacology 20021018 |
| A detailed mapping of the histamine H(3) receptor and its gene transcripts in rat brain. | Neuroscience 20020101 |
| Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE. | Journal of medicinal chemistry 20010524 |
| Different antagonist binding properties of human and rat histamine H3 receptors. | Bioorganic & medicinal chemistry letters 20010409 |
| Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain. | British journal of pharmacology 20001201 |
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