200,000+ products from a single source!
sales@angenechem.com
Home > Imidazoles > 151070-83-6
151070-83-6 | Piperidine, 4-(1H-imidazol-5-ylmethyl)-
CAS No: 151070-83-6 Catalog No: AG001N1J MDL No:
Product Description
Catalog Number:
AG001N1J
Chemical Name:
Piperidine, 4-(1H-imidazol-5-ylmethyl)-
CAS Number:
151070-83-6
Molecular Formula:
C9H15N3
Molecular Weight:
165.2355
IUPAC Name:
4-(1H-imidazol-5-ylmethyl)piperidine
InChI:
InChI=1S/C9H15N3/c1-3-10-4-2-8(1)5-9-6-11-7-12-9/h6-8,10H,1-5H2,(H,11,12)
InChI Key:
MCNGUYXRBCIGOV-UHFFFAOYSA-N
SMILES:
N1CCC(CC1)Cc1[nH]cnc1
Properties
Complexity:
132
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
165.127g/mol
Formal Charge:
0
Heavy Atom Count:
12
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
165.24g/mol
Monoisotopic Mass:
165.127g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
40.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.7
Literature
| Title | Journal |
|---|---|
| Histamine h3 receptor: a novel therapeutic target in alcohol dependence? | Frontiers in systems neuroscience 20120101 |
| Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies. | Journal of medicinal chemistry 20111208 |
| The role of cortical and hypothalamic histamine-3 receptors in the modulation of central histamine neurotransmission: an in vivo electrophysiology and microdialysis study. | The European journal of neuroscience 20111201 |
| Selective histamine H₃ and H₄ receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach. | European journal of pharmacology 20111101 |
| Histamine H3 receptor agonists decrease hypothalamic histamine levels and increase stereotypical biting in mice challenged with methamphetamine. | Neurochemical research 20111001 |
| Evidence for the role of histamine H3 receptor in alcohol consumption and alcohol reward in mice. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110901 |
| Effects of histamine H3 receptor ligands on the rewarding, stimulant and motor-impairing effects of ethanol in DBA/2J mice. | Neuropharmacology 20110601 |
| Effects of histamine H3 receptors on chemical hyperalgesia in diabetic rats. | Neuropharmacology 20110501 |
| Pre-synaptic histamine H₃ receptors modulate glutamatergic transmission in rat globus pallidus. | Neuroscience 20110310 |
| Histamine H3 receptor as a drug discovery target. | Journal of medicinal chemistry 20110113 |
| Histaminergic mechanisms for modulation of memory systems. | Neural plasticity 20110101 |
| Histamine H4 receptor agonists. | Bioorganic & medicinal chemistry letters 20101215 |
| Investigation of the histamine H3 receptor binding site. Design and synthesis of hybrid agonists with a lipophilic side chain. | Journal of medicinal chemistry 20100909 |
| Histamine H(3) receptor modulates nociception in a rat model of cholestasis. | Pharmacology, biochemistry, and behavior 20100901 |
| Synthesis and structure-activity relationships of N-aryl-piperidine derivatives as potent (partial) agonists for human histamine H3 receptor. | Bioorganic & medicinal chemistry 20100715 |
| Anxiolytic-like profiles of histamine H3 receptor agonists in animal models of anxiety: a comparative study with antidepressants and benzodiazepine anxiolytic. | Psychopharmacology 20090801 |
| Acute central administration of immepip, a histamine H3 receptor agonist, suppresses hypothalamic histamine release and elicits feeding behavior in rats. | Brain research bulletin 20090406 |
| Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions. | Psychopharmacology 20090301 |
| Role of histamine in short- and long-term effects of methamphetamine on the developing mouse brain. | Journal of neurochemistry 20081101 |
| Apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats is increased by histidine and decreased by histidine decarboxylase, histamine H1 and H2 receptor antagonists, and an H3 receptor agonist. | Pharmacology, biochemistry, and behavior 20080901 |
| 4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists. | Journal of medicinal chemistry 20080522 |
| Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. | BMC pharmacology 20080101 |
| The role of carcinine in signaling at the Drosophila photoreceptor synapse. | PLoS genetics 20071201 |
| Activation of peripheral and spinal histamine H3 receptors inhibits formalin-induced inflammation and nociception, respectively. | Pharmacology, biochemistry, and behavior 20071101 |
| The Akt/GSK-3beta axis as a new signaling pathway of the histamine H(3) receptor. | Journal of neurochemistry 20071001 |
| Dopamine D(1) receptor facilitation of depolarization-induced release of gamma-amino-butyric acid in rat striatum is mediated by the cAMP/PKA pathway and involves P/Q-type calcium channels. | Synapse (New York, N.Y.) 20070501 |
| Identification of zebrafish histamine H1, H2 and H3 receptors and effects of histaminergic ligands on behavior. | Biochemical pharmacology 20070415 |
| Histamine augments beta2-adrenoceptor-induced cyclic AMP accumulation in human prostate cancer cells DU-145 independently of known histamine receptors. | Biochemical pharmacology 20070315 |
| Sex- and histamine-dependent long-term cognitive effects of methamphetamine exposure. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070301 |
| Pre-synaptic histamine H3 receptors regulate glutamate, but not GABA release in rat thalamus. | Neuropharmacology 20070201 |
| Role of apolipoprotein E in anxiety. | Neural plasticity 20070101 |
| Histaminergic and glycinergic modulation of GABA release in the vestibular nuclei of normal and labyrinthectomised rats. | The Journal of physiology 20061215 |
| Homologous down-regulation of histamine H3 receptors in rat striatal slices. | Synapse (New York, N.Y.) 20060801 |
| Histamine H3 receptor agonists reduce L-dopa-induced chorea, but not dystonia, in the MPTP-lesioned nonhuman primate model of Parkinson's disease. | Movement disorders : official journal of the Movement Disorder Society 20060601 |
| Effect of endogenous histamine in the ventral hippocampus on fear memory deficits induced by scopolamine as evaluated by step-through avoidance response in rats. | Physiology & behavior 20060415 |
| Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists. | Bioorganic & medicinal chemistry letters 20060215 |
| Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold. | Bioorganic & medicinal chemistry letters 20060115 |
| New high affinity H3 receptor agonists without a basic side chain. | Bioorganic & medicinal chemistry 20051201 |
| N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist. | Journal of medicinal chemistry 20050324 |
| Inhibition of chemical and low-intensity mechanical nociception by activation of histamine H3 receptors. | The journal of pain : official journal of the American Pain Society 20050301 |
| Effects of activation of central nervous histamine receptors in cardiovascular regulation; studies in H(1) and H(2) receptor gene knockout mice. | Naunyn-Schmiedeberg's archives of pharmacology 20050201 |
| Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20041006 |
| Intranigral injection of the H3 agonist immepip and systemic apomorphine elicit ipsilateral turning behaviour in naive rats, but reduce contralateral turning in hemiparkinsonian rats. | Behavioural brain research 20041005 |
| Hydroxyzine prevents isolation-induced vocalization in guinea pig pups: comparison with chlorpheniramine and immepip. | Pharmacology, biochemistry, and behavior 20040901 |
| Histamine H3 receptor activation inhibits dopamine D1 receptor-induced cAMP accumulation in rat striatal slices. | Neuroscience letters 20040708 |
| Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain. | Journal of medicinal chemistry 20040603 |
| Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist. | Journal of medicinal chemistry 20040506 |
| Effect of the histamine H3-antagonist clobenpropit on spatial memory deficits induced by MK-801 as evaluated by radial maze in Sprague-Dawley rats. | Behavioural brain research 20040505 |
| [Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20040501 |
| Effects of clobenpropit on pentylenetetrazole-kindled seizures in rats. | European journal of pharmacology 20031215 |
| Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists. | Journal of medicinal chemistry 20031204 |
| Histamine H3 receptors regulate vascular permeability changes in the skin of mast cell-deficient mice. | International immunopharmacology 20031101 |
| Effects of endogenous histamine on seizure development of pentylenetetrazole-induced kindling in rats. | Pharmacology 20030901 |
| H3 agonist immepip markedly reduces cortical histamine release, but only weakly promotes sleep in the rat. | Pharmacological research 20030801 |
| Activation of spinal histamine H3 receptors inhibits mechanical nociception. | European journal of pharmacology 20030606 |
| Molecular and pharmacological characterization of the mouse histamine H3 receptor. | European journal of pharmacology 20030425 |
| Increased brain histamine H3 receptor expression during hibernation in golden-mantled ground squirrels. | BMC neuroscience 20030101 |
| Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. | British journal of pharmacology 20021101 |
| Characteristics of recombinantly expressed rat and human histamine H3 receptors. | European journal of pharmacology 20021018 |
| Activation of histaminergic H3 receptors in the rat basolateral amygdala improves expression of fear memory and enhances acetylcholine release. | The European journal of neuroscience 20020801 |
| Histamine H(2) -like receptors in chick cerebral cortex: effects on cyclic AMP synthesis and characterization by [(3) H]tiotidine binding. | Journal of neurochemistry 20020601 |
| Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H(3) receptor. | Neuropharmacology 20020601 |
| Role of histamine H3 receptors in control of mouse intestinal motility in vivo and in vitro: comparison with alpha2-adrenoceptors. | Digestive diseases and sciences 20020501 |
| Histamine H3 receptor activation inhibits glutamate release from rat striatal synaptosomes. | Neuropharmacology 20011201 |
| Pharmacological analysis of immepip and imetit homologues. Further evidence for histamine H(3) receptor heterogeneity? | Behavioural brain research 20011015 |
| Histamine H(3) receptor-mediated inhibition of depolarization-induced, dopamine D(1) receptor-dependent release of [(3)H]-gamma-aminobutryic acid from rat striatal slices. | British journal of pharmacology 20010501 |
| Genomic organization and characterization of splice variants of the human histamine H3 receptor. | The Biochemical journal 20010415 |
| Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. | Molecular pharmacology 20010301 |
| Cloning, expression, and pharmacological characterization of a novel human histamine receptor. | Molecular pharmacology 20010301 |
| Identification of a histamine H(3)-like receptor in the zebrafish (Danio rerio) brain. | Journal of neurochemistry 20000801 |
| Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles. | The Journal of pharmacology and experimental therapeutics 20000601 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.