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15060-55-6 | Ammonium Tetrathiomolybdate
CAS No: 15060-55-6 Catalog No: AG0034GV MDL No:MFCD00136013
Product Description
Catalog Number:
AG0034GV
Chemical Name:
Ammonium Tetrathiomolybdate
CAS Number:
15060-55-6
Molecular Formula:
H8MoN2S4
Molecular Weight:
260.2969
MDL Number:
MFCD00136013
IUPAC Name:
diazanium;bis(sulfanylidene)molybdenum;sulfanide
InChI:
InChI=1S/Mo.2H3N.2H2S.2S/h;2*1H3;2*1H2;;
InChI Key:
ZKKLPDLKUGTPME-UHFFFAOYSA-N
SMILES:
[S-][Mo](=S)(=S)[S-].[NH4+].[NH4+]
UNII:
4V6I63LW1E
Properties
Complexity:
19.1
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
5
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
263.878g/mol
Formal Charge:
0
Heavy Atom Count:
7
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
262.284g/mol
Monoisotopic Mass:
263.878g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
68.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Copper induces--and copper chelation by tetrathiomolybdate inhibits--endothelial activation in vitro. | Redox report : communications in free radical research 20140101 |
| Responsiveness of prehaemolytic copper poisoning in sheep from a specific pathogen-free environment to a relatively high dose of tetrathiomolybdate. | The Veterinary record 20120908 |
| Residual effects of Mycobacterium avium infection on susceptibility of sheep to copper toxicity and efficacy of treatment with tetrathiomolybdate. | The Veterinary record 20120707 |
| Effects of clonidine and idazoxan on tetrathiomolybdate-induced copper and lysosomal enzyme excretion into sheep bile. | Research in veterinary science 20120601 |
| Tetrathiomolybdate sensitizes ovarian cancer cells to anticancer drugs doxorubicin, fenretinide, 5-fluorouracil and mitomycin C. | BMC cancer 20120101 |
| Role of the rumen in copper and thiomolybdate absorption. | Nutrition research reviews 20111201 |
| Copper deficiency exacerbates bile duct ligation-induced liver injury and fibrosis in rats. | The Journal of pharmacology and experimental therapeutics 20111001 |
| Prognostic significance of neurologic examination findings in Wilson disease. | Parkinsonism & related disorders 20110801 |
| Antitumor activity of nifurtimox is enhanced with tetrathiomolybdate in medulloblastoma. | International journal of oncology 20110501 |
| The significance of copper chelators in clinical and experimental application. | The Journal of nutritional biochemistry 20110401 |
| Development of a new bimodal imaging methodology: a combination of fluorescence microscopy and high-resolution secondary ion mass spectrometry. | Journal of microscopy 20101001 |
| Tetrathiomolybdate mediated rearrangement of aziridinemethanol tosylates: a thia-aza-Payne rearrangement. | The Journal of organic chemistry 20100820 |
| Effect of glutathione depletion on removal of copper from LEC rat livers by tetrathiomolybdate. | Journal of inorganic biochemistry 20100801 |
| Is there a role for tetrathiomolybdate in the treatment of primary biliary cirrhosis? | Translational research : the journal of laboratory and clinical medicine 20100301 |
| Treatment of primary biliary cirrhosis with tetrathiomolybdate: results of a double-blind trial. | Translational research : the journal of laboratory and clinical medicine 20100301 |
| Superoxide generated by lysophosphatidylcholine induces endothelial nitric oxide synthase downregulation in human endothelial cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101 |
| Stimulation of angiogenesis resulting from cooperation between macrophages and MDA-MB-231 breast cancer cells: proposed molecular mechanism and effect of tetrathiomolybdate. | BMC cancer 20100101 |
| Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis. | Molecular cancer 20100101 |
| Antiangiogenic tetrathiomolybdate protects against Her2/neu-induced breast carcinoma by hypoplastic remodeling of the mammary gland. | Clinical cancer research : an official journal of the American Association for Cancer Research 20091201 |
| Redox-related antimelanoma activity of ATN-224. | Melanoma research 20091201 |
| Direct synthesis of functionalized unsymmetrical beta-sulfonamido disulfides by tetrathiomolybdate mediated aziridine ring-opening reactions. | The Journal of organic chemistry 20091016 |
| Treatment of Wilson's disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientine. | Translational research : the journal of laboratory and clinical medicine 20090801 |
| Improvement in dissolution of liver fibrosis in an animal model by tetrathiomolybdate. | Experimental biology and medicine (Maywood, N.J.) 20090601 |
| Status epilepticus in Wilson's disease. | Epileptic disorders : international epilepsy journal with videotape 20090601 |
| Copper chelator ATN-224 inhibits endothelial function by multiple mechanisms. | Microvascular research 20090501 |
| A pilot trial of the anti-angiogenic copper lowering agent tetrathiomolybdate in combination with irinotecan, 5-flurouracil, and leucovorin for metastatic colorectal cancer. | Investigational new drugs 20090401 |
| Molybdenum X-ray absorption edges from 200 to 20,000eV: the benefits of soft X-ray spectroscopy for chemical speciation. | Journal of inorganic biochemistry 20090201 |
| Role of copper ion in the pathogenesis of type 2 diabetes. | Endocrine journal 20090101 |
| Phase I study of copper-binding agent ATN-224 in patients with advanced solid tumors. | Clinical cancer research : an official journal of the American Association for Cancer Research 20081115 |
| Efficacy of tetrathiomolybdate in a mouse model of multiple sclerosis. | Translational research : the journal of laboratory and clinical medicine 20081101 |
| Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis. | Experimental neurology 20080901 |
| Tetrathiomolybdate is partially protective against hyperglycemia in rodent models of diabetes. | Experimental biology and medicine (Maywood, N.J.) 20080801 |
| Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling. | Proceedings of the National Academy of Sciences of the United States of America 20080520 |
| Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis. | The Journal of pharmacology and experimental therapeutics 20080501 |
| Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224). | British journal of cancer 20080226 |
| Effects of ammonium tetrathiomolybdate, an oncolytic/angiolytic drug on the viability and proliferation of endothelial and tumor cells. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20071201 |
| Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors. | Bioorganic & medicinal chemistry letters 20071115 |
| Reversible precipitation of bovine serum albumin by metal ions and synthesis, structure and reactivity of new tetrathiometallate chelating agents. | Journal of inorganic biochemistry 20071101 |
| Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. | Experimental cell research 20070910 |
| Novel chalcogenides of thymidine and uridine: synthesis, properties and applications. | Carbohydrate research 20070702 |
| Wilson disease--a practical approach to diagnosis, treatment and follow-up. | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070701 |
| Antitumor and antiinflammatory effects of tetrathiotungstate in comparison with tetrathiomolybdate. | Translational research : the journal of laboratory and clinical medicine 20070501 |
| Comparison of lowering copper levels with tetrathiomolybdate and zinc on mouse tumor and doxorubicin models. | Translational research : the journal of laboratory and clinical medicine 20061201 |
| Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. | Clinical cancer research : an official journal of the American Association for Cancer Research 20060815 |
| Promising pharmacologic innovations in treating pulmonary fibrosis. | Current opinion in pharmacology 20060601 |
| Effect of copper and thiomolybdates on bovine theca cell differentiation in vitro. | The Journal of endocrinology 20060601 |
| The use of tetrathiomolybdate in treating fibrotic, inflammatory, and autoimmune diseases, including the non-obese diabetic mouse model. | Journal of inorganic biochemistry 20060501 |
| Treatment of Wilson disease with ammonium tetrathiomolybdate: IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of Wilson disease. | Archives of neurology 20060401 |
| Combination tetrathiomolybdate and radiation therapy in a mouse model of head and neck squamous cell carcinoma. | Archives of otolaryngology--head & neck surgery 20060301 |
| Copper kinetics and hepatic glutathione levels in the copper exposed frog Rana ridibunda after tetrathiomolybdate treatment. | Bulletin of environmental contamination and toxicology 20060301 |
| Novel therapeutic approaches to the treatment of Wilson's disease. | Expert opinion on pharmacotherapy 20060201 |
| Tetrathiomolybdate protects against cardiac damage by doxorubicin in mice. | The Journal of laboratory and clinical medicine 20051101 |
| Chemistry of tetrathiomolybdate: aziridine ring opening reactions and facile synthesis of interesting sulfur heterocycles. | Journal of the American Chemical Society 20050921 |
| Anticopper therapy against cancer and diseases of inflammation and fibrosis. | Drug discovery today 20050815 |
| Effects of tetrathiomolybdate in a mouse model of retinal neovascularization. | Investigative ophthalmology & visual science 20050101 |
| Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment. | CNS drugs 20050101 |
| Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats. | Arthritis research & therapy 20050101 |
| Inhibition of key cytokines by tetrathiomolybdate in the bleomycin model of pulmonary fibrosis. | Journal of inorganic biochemistry 20041201 |
| [Wilson's disease and its pharmacological treatment]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20041101 |
| Solid state imposed vibrational coupling between nu1 and nu3 modes of tetrahedral ions. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20041001 |
| Tetrathiomolybdate therapy protects against concanavalin a and carbon tetrachloride hepatic damage in mice. | Experimental biology and medicine (Maywood, N.J.) 20040901 |
| Idiopathic pulmonary fibrosis: emerging concepts on pharmacotherapy. | Expert opinion on pharmacotherapy 20040801 |
| [Wilson disease in 2003]. | Orvosi hetilap 20031214 |
| Wilson disease. | Mayo Clinic proceedings 20030901 |
| Selective reduction of anomeric azides to amines with tetrathiomolybdate: synthesis of beta-D-glycosylamines. | The Journal of organic chemistry 20030627 |
| Antiangiogenic therapy through copper chelation. | Expert opinion on therapeutic targets 20030601 |
| Expression of lysyl oxidase and effect of copper chloride and ammonium tetrathiomolybdate on bovine ovarian follicle granulosa cells cultured in serum-free media. | Reproduction (Cambridge, England) 20030501 |
| Tetrathiomolybdate therapy protects against bleomycin-induced pulmonary fibrosis in mice. | The Journal of laboratory and clinical medicine 20030301 |
| Treatment of Wilson disease with ammonium tetrathiomolybdate: III. Initial therapy in a total of 55 neurologically affected patients and follow-up with zinc therapy. | Archives of neurology 20030301 |
| [Wilson's disease: physiopathological, clinical and therapeutic considerations]. | Gastroenterologia y hepatologia 20030101 |
| Tetrathiomolybdate anticopper therapy for Wilson's disease inhibits angiogenesis, fibrosis and inflammation. | Journal of cellular and molecular medicine 20030101 |
| The involvement of a multicopper oxidase in iron uptake by the green algae Chlamydomonas reinhardtii. | Plant physiology 20021201 |
| Suppression of tumor recurrence and metastasis by a combination of the PHSCN sequence and the antiangiogenic compound tetrathiomolybdate in prostate carcinoma. | Neoplasia (New York, N.Y.) 20020901 |
| Diagnosis and treatment of Wilson's disease. | Current neurology and neuroscience reports 20020701 |
| Kayser-Fleischer ring as the presenting sign of Wilson disease. | American journal of ophthalmology 20020601 |
| Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate as an effective deblocking agent for the Poc group. | Chemical communications (Cambridge, England) 20020421 |
| Radiotherapy and antiangiogenic TM in lung cancer. | Neoplasia (New York, N.Y.) 20020301 |
| Reduction of copper and metallothionein in toxic milk mice by tetrathiomolybdate, but not deferiprone. | Journal of inorganic biochemistry 20020115 |
| Tetrathiomolybdate as an antiangiogenesis therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration. | Transactions of the American Ophthalmological Society 20020101 |
| Tetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase. | FEBS letters 20011102 |
| Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress. | The Journal of biological chemistry 20010706 |
| Peptides mimicking the N-terminal Cu(II)-binding site of bovine serum albumin: synthesis, characterization and coordination with Cu(II) ions. | Journal of inorganic biochemistry 20010501 |
| UV/visible spectrophotometric studies of the interactions of thiomolybdates, copper(II) and other ligands. | Journal of inorganic biochemistry 20010501 |
| Treatment of Wilson's disease: what are the relative roles of penicillamine, trientine, and zinc supplementation? | Current gastroenterology reports 20010201 |
| Treatment of the neurologic manifestations of Wilson's disease. | Archives of neurology 19950401 |
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