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149394-66-1

149394-66-1 | Phosphonic acid, P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-, hydrate (1:2)

CAS No: 149394-66-1 Catalog No: AG001LO2 MDL No:MFCD16556167

Product Description

Catalog Number:
AG001LO2
Chemical Name:
Phosphonic acid, P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-, hydrate (1:2)
CAS Number:
149394-66-1
Molecular Formula:
C8H18N3O8P
Molecular Weight:
315.2176
MDL Number:
MFCD16556167
IUPAC Name:
[(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid;dihydrate
InChI:
InChI=1S/C8H14N3O6P.2H2O/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16;;/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16);2*1H2/t6-;;/m0../s1
InChI Key:
FPKARFMSZDBYQF-ILKKLZGPSA-N
SMILES:
OC[C@H](Cn1ccc(nc1=O)N)OCP(=O)(O)O.O.O
UNII:
JIL713Q00N

Properties

Complexity:
417  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
315.083g/mol
Formal Charge:
0
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0
Molecular Weight:
315.219g/mol
Monoisotopic Mass:
315.083g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
148A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Literature

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Biopsy-proven adenoviral diarrhea responding to low-dose cidofovir. Transplant infectious disease : an official journal of the Transplantation Society 20081001
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Case report: persistent cytomegalovirus (CMV) infection after haploidentical hematopoietic stem cell transplantation using in vivo alemtuzumab: emergence of resistant CMV due to mutations in the UL97 and UL54 genes. Journal of medical virology 20081001
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Side-effects of cidofovir in the treatment of recurrent respiratory papillomatosis. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080801
Scientific and clinical aspects of the use of cidofovir in recurrent respiratory papillomatosis. International journal of pediatric otorhinolaryngology 20080701
Cidofovir inhibits polyomavirus BK replication in human renal tubular cells downstream of viral early gene expression. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20080701
Cidofovir efficacy in recurrent respiratory papillomatosis: a randomized, double-blind, placebo-controlled study. The Annals of otology, rhinology, and laryngology 20080701
Aggressive recurrent respiratory papillomatosis in a neonate. International journal of pediatric otorhinolaryngology 20080601
Successful cidofovir treatment in an adult heart transplant recipient with severe adenovirus pneumonia. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20080601
Severe eczema vaccinatum in a household contact of a smallpox vaccinee. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080515
Cidofovir diphosphate inhibits molluscum contagiosum virus DNA polymerase activity. The Journal of investigative dermatology 20080501
Treatment of locally recurrent Epstein-Barr virus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir. Journal of medical virology 20080501
An adenovirus type F41 outbreak in a pediatric bone marrow transplant unit: analysis of clinical impact and preventive strategies. The Pediatric infectious disease journal 20080501
Adult intralesional cidofovir therapy for laryngeal papilloma: a 10-year perspective. Archives of otolaryngology--head & neck surgery 20080501
Cidofovir in combination with HAART and survival in AIDS-associated progressive multifocal leukoencephalopathy. Journal of neurology 20080401
Differential pathogenesis of cowpox virus intranasal infections in mice induced by low and high inoculum volumes and effects of cidofovir treatment. International journal of antimicrobial agents 20080401
Cowpox virus infection: an emerging health threat. Current opinion in infectious diseases 20080401
[Treatment of pediatric genital condyloma]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20080401
BK virus-associated nephropathy in a kidney transplant recipient successfully treated with cidofovir, the first case in Japan. International journal of urology : official journal of the Japanese Urological Association 20080401
A single-center experience with BK virus nephropathy. Clinical nephrology 20080401
[Extensive oral condylomas treated by in situ cidofovir injection in an HIV patient]. Annales de dermatologie et de venereologie 20080401
Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia. Pediatric blood & cancer 20080301
Characterization of a cidofovir-resistant HHV-6 mutant obtained by in vitro selection. Antiviral research 20080301
High-risk adenovirus-infected pediatric allogeneic hematopoietic progenitor cell transplant recipients and preemptive cidofovir therapy. Pediatric transplantation 20080301
[Resolution of recalcitrant condyloma acuminata in a patient with human immunodeficiency virus treated with cidofovir]. Actas dermo-sifiliograficas 20080301
Cidofovir injection for recurrent laryngeal papillomatosis. Journal of the Chinese Medical Association : JCMA 20080301
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