CAS 149-87-1 | Proline, 5-oxo- | CAS Number 149-87-1

Title	Journal
The adipokinetic hormone of the coleopteran suborder Adephaga: Structure, function, and comparison of distribution in other insects.	Archives of insect biochemistry and physiology 20170701
The dental monomer hydroxyethyl methacrylate (HEMA) counteracts lipopolysaccharide-induced IL-1β release-Possible role of glutathione.	Toxicology letters 20170315
The adipokinetic hormone of Mantodea in comparison to other Dictyoptera.	Archives of insect biochemistry and physiology 20170301
Promising toxicological biomarkers for the diagnosis of liver injury types: Bile acid metabolic profiles and oxidative stress marker as screening tools in drug development.	Chemico-biological interactions 20160805
Actions of Bisphenol A and Bisphenol S on the Reproductive Neuroendocrine System During Early Development in Zebrafish.	Endocrinology 20160201
Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct.	The Journal of investigative dermatology 20140301
Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures.	PloS one 20140101
Five functional adipokinetic peptides expressed in the corpus cardiacum of the moth genus Hippotion (Lepidoptera, Sphingidae).	Regulatory peptides 20130610
Novel adipokinetic hormones in the kissing bugs Rhodnius prolixus, Triatoma infestans, Dipetalogaster maxima and Panstrongylus megistus.	Peptides 20130301
Modulation of airway epithelial cell functions by Pidotimod: NF-kB cytoplasmatic expression and its nuclear translocation are associated with an increased TLR-2 expression.	Italian journal of pediatrics 20130101
Energy-dependent modulation of glucagon-like signaling in Drosophila via the AMP-activated protein kinase.	Genetics 20121001
Serum metabolic signatures of fulminant type 1 diabetes.	Journal of proteome research 20120907
Composition and antimicrobial activity of fatty acids detected in the hygroscopic secretion collected from the secretory setae of larvae of the biting midge Forcipomyia nigra (Diptera: Ceratopogonidae).	Journal of insect physiology 20120901
Role of liquid chromatography-high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology.	Clinical toxicology (Philadelphia, Pa.) 20120901
Impact of filaggrin mutations on Raman spectra and biophysical properties of the stratum corneum in mild to moderate atopic dermatitis.	Journal of the European Academy of Dermatology and Venereology : JEADV 20120801
Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II.	Endocrinology 20120801
A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism.	European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120716
Plant growth stimulation in Prunus species plantlets by BTH or OTC treatments under in vitro conditions.	Journal of plant physiology 20120715
Recombinant production of isotope-labeled peptides and spontaneous cyclization of amino-terminal glutamine into pyroglutamic acid.	Chembiochem : a European journal of chemical biology 20120709
5-oxoprolinemia causing elevated anion gap metabolic acidosis in the setting of acetaminophen use.	The Journal of emergency medicine 20120701
Pyroglutamyl peptidase II inhibition enhances the analeptic effect of thyrotropin-releasing hormone in the rat medial septum.	The Journal of pharmacology and experimental therapeutics 20120701
Structure-activity studies of Drosophila adipokinetic hormone (AKH) by a cellular expression system of dipteran AKH receptors.	General and comparative endocrinology 20120701
N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation.	Journal of neurochemistry 20120601
GnRH-III based multifunctional drug delivery systems containing daunorubicin and methotrexate.	European journal of medicinal chemistry 20120601
Molecular imaging of dementia.	Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 20120601
Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats.	BMB reports 20120601
Gustatory perception and fat body energy metabolism are jointly affected by vitellogenin and juvenile hormone in honey bees.	PLoS genetics 20120601
Aggressive behavior and reproductive physiology in females of the social cichlid fish Cichlasoma dimerus.	Physiology & behavior 20120515
Rapid, simultaneous and nanomolar determination of pyroglutamic acid and cis-/trans-urocanic acid in human stratum corneum by hydrophilic interaction liquid chromatography (HILIC)-electrospray ionization tandem mass spectrometry.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120515
Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin.	Organic & biomolecular chemistry 20120507
Functional characterization of the adipokinetic hormone in the pea aphid, Acyrthosiphon pisum.	Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20120501
Decreased lactate and potassium levels in natural moisturizing factor from the stratum corneum of mild atopic dermatitis patients are involved with the reduced hydration state.	Journal of dermatological science 20120501
Italian guidelines for primary headaches: 2012 revised version.	The journal of headache and pain 20120501
New peptide pENW (pGlu-Asn-Trp) inhibits platelet activation by attenuating Akt phosphorylation.	European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120411
Chiral sensing using an achiral europium(III) complex by induced circularly polarized luminescence.	Inorganic chemistry 20120402
Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease.	The Journal of biological chemistry 20120309
Protective effect of a cysteine prodrug and antioxidant, L-2-oxothiazolidine-4-carboxylate, against ethanol-induced gastric lesions in rats.	Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120301
Sequencing and biological effects of an adipokinetic/hypertrehalosemic peptide in the stick insect, Baculum extradentatum.	Peptides 20120301
Active diuretic peptidomimetic insect kinin analogs that contain β-turn mimetic motif 4-aminopyroglutamate and lack native peptide bonds.	Peptides 20120301
Adipokinetic hormone-induced antioxidant response in Spodoptera littoralis.	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20120301
Zinc l-pyrrolidone carboxylate inhibits the UVA-induced production of matrix metalloproteinase-1 by in vitro cultured skin fibroblasts, whereas it enhances their collagen synthesis.	International journal of cosmetic science 20120201
Role of brainstem thyrotropin-releasing hormone-triggered sympathetic overactivation in cardiovascular mortality in type 2 diabetic Goto-Kakizaki rats.	Hypertension research : official journal of the Japanese Society of Hypertension 20120201
Elevated cytokinin content in ipt transgenic creeping bentgrass promotes drought tolerance through regulating metabolite accumulation.	Journal of experimental botany 20120201
The retina is a target for GnRH-3 system in the European sea bass, Dicentrarchus labrax.	General and comparative endocrinology 20120201
Multiple strategies to prevent oxidative stress in Arabidopsis plants lacking the malate valve enzyme NADP-malate dehydrogenase.	Journal of experimental botany 20120201
Quantitative determination of pidotimod in human plasma by liquid chromatography tandem mass spectrometry: application to a bioequivalence study.	Arzneimittel-Forschung 20120201
Developing a comparative docking protocol for the prediction of peptide selectivity proﬁles: investigation of potassium channel toxins.	Toxins 20120201
A fluorescence-based microtiter plate assay for γ-glutamylcyclotransferase.	Analytical biochemistry 20120115
Two flushing-like reaction cases from calcium pidolate who tolerated calcium carbonate.	Allergologia et immunopathologia 20120101
Detection of peri-synaptic amyloid-β pyroglutamate aggregates in early stages of Alzheimer's disease and in AβPP transgenic mice using a novel monoclonal antibody.	Journal of Alzheimer's disease : JAD 20120101
Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect.	The Journal of investigative dermatology 20120101
The effect of adipokinetic hormone on midgut characteristics in Pyrrhocoris apterus L. (Heteroptera).	Journal of insect physiology 20120101
A distinct metabolic signature predicts development of fasting plasma glucose.	Journal of clinical bioinformatics 20120101
Glutathione homeostasis and functions: potential targets for medical interventions.	Journal of amino acids 20120101
Magnesium and vascular changes in hypertension.	International journal of hypertension 20120101
Metabolomics as a Hypothesis-Generating Functional Genomics Tool for the Annotation of Arabidopsis thaliana Genes of 'Unknown Function'.	Frontiers in plant science 20120101
Chronic acetaminophen ingestion resulting in severe anion gap metabolic acidosis secondary to 5-oxoproline accumulation: an under diagnosed phenomenon.	BMJ case reports 20120101
L-2-Oxothiazolidine-4-carboxylic acid or α-lipoic acid attenuates airway remodeling: involvement of nuclear factor-κB (NF-κB), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and hypoxia-inducible factor (HIF).	International journal of molecular sciences 20120101
Identification and functional characterization of two orphan G-protein-coupled receptors for adipokinetic hormones from silkworm Bombyx mori.	The Journal of biological chemistry 20111209
Neuroprotective effects of neurokinin receptor one in dopaminergic neurons are mediated through Akt/PKB cell signaling pathway.	Neuropharmacology 20111201
Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease.	Human psychopharmacology 20111201
[Study on the chemical constituents from the ethyl acetate extracts of Cremastra appendiculata].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20111201
Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core.	Neuroscience letters 20111114
Pyroglutamate amyloid-β (Aβ): a hatchet man in Alzheimer disease.	The Journal of biological chemistry 20111111
Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin.	The Journal of investigative dermatology 20111101
HPLC-MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium.	Journal of pharmaceutical and biomedical analysis 20111101
Cuts by caspase-14 control the proteolysis of filaggrin.	The Journal of investigative dermatology 20111101
An invertebrate [hydroxyproline]-modified neuropeptide: further evidence for a close evolutionary relationship between insect adipokinetic hormone and mammalian gonadotropin hormone family.	Biochemical and biophysical research communications 20111028
Spirocyclic systems derived from pyroglutamic acid.	Organic & biomolecular chemistry 20111021
A facile Cu(I)/BINAP-catalyzed asymmetric approach to functionalized pyroglutamate derivatives bearing a unique quaternary stereogenic center.	Organic letters 20111021
Recurrent anion gap metabolic acidosis in a woman with vertebral disc disease.	The American journal of emergency medicine 20111001
Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats.	Alcoholism, clinical and experimental research 20111001
Anti-diabetic effect of pyroglutamic acid in type 2 diabetic Goto-Kakizaki rats and KK-Ay mice.	The British journal of nutrition 20111001
Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase.	The Journal of endocrinology 20111001
Sexual dimorphism of gonadotropin-releasing hormone type-III (GnRH3) neurons and hormonal sex reversal of male reproductive behavior in Mozambique tilapia.	Zoological science 20111001
Two new compounds from the endophytic fungus Colletotrichum sp. L10 of Cephalotaxus hainanensis.	Journal of Asian natural products research 20111001
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.	The Journal of neuroscience : the official journal of the Society for Neuroscience 20110907
Influences of methamphetamine-induced acute intoxication on urinary and plasma metabolic profiles in the rat.	Toxicology 20110905
L-2-oxothiazolidine-4-carboxylate influence on age- and heat exposure-dependent redox changes in rat's blood plasma.	The journal of physiological sciences : JPS 20110901
Unveiling the roles of the glutathione redox system in vivo by analyzing genetically modified mice.	Journal of clinical biochemistry and nutrition 20110901
Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease.	Neurobiology of aging 20110801
Intraneuronal Aβ as a trigger for neuron loss: can this be translated into human pathology?	Biochemical Society transactions 20110801
Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4.	Bioconjugate chemistry 20110720
In vitro degradation and antitumor activity of oxime bond-linked daunorubicin-GnRH-III bioconjugates and DNA-binding properties of daunorubicin-amino acid metabolites.	Amino acids 20110701
Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity.	Allergy 20110701
Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells.	Investigative ophthalmology & visual science 20110701
Expression of vesicular glutamate transporter-2.1 in medaka terminal nerve gonadotrophin-releasing hormone neurones.	Journal of neuroendocrinology 20110701
Application of gene targeting to designed mutation breeding of high-tryptophan rice.	Plant physiology 20110701
Angiotensin II type 1 receptor signaling regulates feeding behavior through anorexigenic corticotropin-releasing hormone in hypothalamus.	The Journal of biological chemistry 20110617
Synthesis of quaternary stereogenic centres via stereoselective intermolecular Friedel-Crafts reactions.	Organic & biomolecular chemistry 20110607
Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms.	Acta neuropathologica 20110601
A GC/MS-based metabolomic approach for diagnosing citrin deficiency.	Analytical and bioanalytical chemistry 20110601
Water-in-oil-in-water double emulsions: an excellent delivery system for improving the oral bioavailability of pidotimod in rats.	Journal of pharmaceutical sciences 20110601
Self-double-emulsifying drug delivery system (SDEDDS): a new way for oral delivery of drugs with high solubility and low permeability.	International journal of pharmaceutics 20110516
Oxidative stress elicited by insecticides: a role for the adipokinetic hormone.	General and comparative endocrinology 20110515
Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteine.	American journal of respiratory cell and molecular biology 20110501
In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity.	Archives of toxicology 20110501
Brain-gut interactions between central vagal activation and abdominal surgery to influence gastric myenteric ganglia Fos expression in rats.	Peptides 20110501
Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.	The Journal of biological chemistry 20110422
N-terminal glutamate to pyroglutamate conversion in vivo for human IgG2 antibodies.	The Journal of biological chemistry 20110401
Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish.	Endocrinology 20110401
Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland.	Biochemical and biophysical research communications 20110401
Preparation and chiro-optical characterization of polyaniline doped with (+) or (-)-2-pyrrolidone-5-carboxylic acid (PCA).	Chirality 20110401
Temperature affects brain and pituitary gene expression related to reproduction and growth in the male blue gouramis, Trichogaster trichopterus.	Journal of experimental zoology. Part A, Ecological genetics and physiology 20110401
A sister group contrast using untargeted global metabolomic analysis delineates the biochemical regulation underlying desiccation tolerance in Sporobolus stapfianus.	The Plant cell 20110401
Novel methodologies for the synthesis of functionalized pyroglutamates.	Chemical communications (Cambridge, England) 20110321
The first decapeptide adipokinetic hormone (AKH) in Heteroptera: a novel AKH from a South African saucer bug, Laccocoris spurcus (Naucoridae, Laccocorinae).	Peptides 20110301
Non-invasive monitoring of L-2-oxothiazolidine-4-carboxylate metabolism in the rat brain by in vivo 13C magnetic resonance spectroscopy.	Neurochemical research 20110301
Chiral recognition at one-dimensional metal-organic coordination networks initiates the ordering of prochiral catalytic reagent methylacetoacetate on Au{111}.	Langmuir : the ACS journal of surfaces and colloids 20110301
Arginine-vasopressin V1a receptor inhibition improves neurologic outcomes following an intracerebral hemorrhagic brain injury.	Neurochemistry international 20110301
Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.	The Journal of biological chemistry 20110211
Mind the gap! An unusual metabolic acidosis.	Lancet (London, England) 20110205
Calcium and zinc complexes of pyrroglutamate analogs detected by electrospray ionization mass spectrometry.	Amino acids 20110201
Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status.	Chemico-biological interactions 20110201
Removal of N-terminal blocking groups from proteins.	Current protocols in protein science 20110201
[Role of the brain in the regulation of metabolism and energy expenditure: the central role of insulin, and insulin resistance of the brain].	Orvosi hetilap 20110116
Seasonal changes of brain GnRH-I, -II, and -III during the final reproductive period in adult male and female sea lamprey.	General and comparative endocrinology 20110115
A method for N-terminal de novo sequencing of Nα-blocked proteins by mass spectrometry.	The Analyst 20110107
The systemic inhibition of nitric oxide production rapidly regulates TRH mRNA concentration in the paraventricular nucleus of the hypothalamus and serum TSH concentration. Studies in control and cold-stressed rats.	Brain research 20110107
Compensatory expression and substrate inducibility of gamma-glutamyl transferase GGT2 isoform in Arabidopsis thaliana.	Journal of experimental botany 20110101
Luteinizing Hormone-Releasing Hormone (LHRH)-I antagonist cetrorelix inhibits myeloma cell growth in vitro and in vivo.	Molecular cancer therapeutics 20110101
The putative AKH receptor of the tobacco hornworm, Manduca sexta, and its expression.	Journal of insect science (Online) 20110101
Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound.	BMC chemical biology 20110101
NC1900, an arginine vasopressin analogue, fails to reduce brain edema and improve neurobehavioral deficits in an intracerebral hemorrhagic stroke mice model.	Acta neurochirurgica. Supplement 20110101
Isolation and identification of the umami enhancing compounds in Japanese soy sauce.	Bioscience, biotechnology, and biochemistry 20110101
Mn bioavailability by polarized Caco-2 cells: comparison between Mn gluconate and Mn oxyprolinate.	Nutrition journal 20110101
Renal mitochondrial cytopathies.	International journal of nephrology 20110101
Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.	Molecular systems biology 20110101
Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites.	International journal of molecular sciences 20110101
[Dynamics of antipirin test at patients with alcoholic liver disease on the background of metadoksin drug receiving].	Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101
Prediction of protein modification sites of pyrrolidone carboxylic acid using mRMR feature selection and analysis.	PloS one 20110101
Pyroglutamic aciduria: a cause of high anion-gap metabolic acidosis associated with common drugs.	Irish medical journal 20110101
Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.	The Journal of biological chemistry 20101231
Cytotoxicity of dentine bonding agents on human pulp cells is related to intracellular glutathione levels.	International endodontic journal 20101201
Influence of synthetic lamprey GnRH-III on gonadotropin release and steroid hormone levels in gilts.	Theriogenology 20101201
Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in rats.	Peptides 20101201
Pyroglutamate-Aβ: role in the natural history of Alzheimer's disease.	The international journal of biochemistry & cell biology 20101201
Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus.	The Journal of allergy and clinical immunology 20101201
Signal transduction, plasma membrane calcium movements, and pigment translocation in freshwater shrimp chromatophores.	Journal of experimental zoology. Part A, Ecological genetics and physiology 20101101
A unified strategy targeting the thiodiketopiperazine mycotoxins exserohilone, gliotoxin, the epicoccins, the epicorazines, rostratin A and aranotin.	Chemistry (Weinheim an der Bergstrasse, Germany) 20101011
Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein.	Journal of medicinal chemistry 20100923
Zinc ions bind to and inhibit activated protein C.	Thrombosis and haemostasis 20100901
Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.	Bioorganic & medicinal chemistry letters 20100901
Oral magnesium supplementation improves vascular function in elderly diabetic patients.	Magnesium research 20100901
5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose.	The Journal of the American Osteopathic Association 20100901
Profound metabolic acidosis from pyroglutamic acidemia: an underappreciated cause of high anion gap metabolic acidosis.	CJEM 20100901
Potent hyperglycemic and hyperinsulinemic effects of thyrotropin-releasing hormone microinjected into the rostroventrolateral medulla and abnormal responses in type 2 diabetic rats.	Neuroscience 20100825
Complementary treatment with oral pidotimod plus vitamin C after laser vaporization for female genital warts: a prospective study.	Journal of medicine and life 20100815
Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease.	Acta neuropathologica 20100801
Characterization of intrathecally administered hemokinin-1-induced nociceptive behaviors in mice.	Peptides 20100801
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of adefovir in human plasma and its application to a pharmacokinetic study.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100801
Adult Drosophila melanogaster as a model for the study of glucose homeostasis.	Aging 20100801
Negligible effect of oral garlic oil on the oral absorption of pyridoxine in metadoxine in rats.	Archives of pharmacal research 20100701
Role of late maternal thyroid hormones in cerebral cortex development: an experimental model for human prematurity.	Cerebral cortex (New York, N.Y. : 1991) 20100601
Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter.	Biochimica et biophysica acta 20100601
OXP1/YKL215c encodes an ATP-dependent 5-oxoprolinase in Saccharomyces cerevisiae: functional characterization, domain structure and identification of actin-like ATP-binding motifs in eukaryotic 5-oxoprolinases.	FEMS yeast research 20100601
Acute administration of 5-oxoproline induces oxidative damage to lipids and proteins and impairs antioxidant defenses in cerebral cortex and cerebellum of young rats.	Metabolic brain disease 20100601
Signal pathway of GnRH-III inhibiting FSH-induced steroidogenesis in granulosa cells.	Frontiers in bioscience (Elite edition) 20100601
A role of Histidine151 in the lamprey gonadotropin-releasing hormone receptor-1 (lGnRHR-1): Functional insight of diverse amino acid residues in the position of Tyr of the DRY motif in GnRHR from an ancestral type II receptor.	General and comparative endocrinology 20100501
Locust adipokinetic hormones mobilize diacylglycerols selectively.	Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20100501
Cytosolic action of phytochelatin synthase.	Plant physiology 20100501
Cytotoxicity of chlorhexidine on human osteoblastic cells is related to intracellular glutathione levels.	International endodontic journal 20100501
A second gene encodes the anti-diuretic hormone in the insect, Rhodnius prolixus.	Molecular and cellular endocrinology 20100412
Quantification of thyrotropin-releasing hormone by liquid chromatography-electrospray mass spectrometry.	Amino acids 20100401
A novel function of red pigment-concentrating hormone in crustaceans: Porcellio scaber (Isopoda) as a model species.	General and comparative endocrinology 20100401
Glutathione modulators reverse the pro-tumour effect of growth factors enhancing WiDr cell response to chemotherapeutic agents.	Anticancer research 20100401
Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism.	The Journal of biological chemistry 20100326
Synthesis of amino acid conjugates to 2-imino-3-methylene-5-carboxypyrrolidine and 2-imino-3-methylene-6-carboxypiperidine.	Bioorganic & medicinal chemistry letters 20100315
Nephrolithiasis related to inborn metabolic diseases.	Pediatric nephrology (Berlin, Germany) 20100301
Biological activity of the predicted red pigment-concentrating hormone of Daphnia pulex in a crustacean and an insect.	General and comparative endocrinology 20100301
A novel member of the adipokinetic peptide family in a 'living fossil', the ice crawler Galloisiana yuasai, is the first identified neuropeptide from the order Grylloblattodea.	Peptides 20100301
A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?	Journal of biosciences 20100301
Studies in serum support rapid formation of disulfide bond between unpaired cysteine residues in the VH domain of an immunoglobulin G1 molecule.	Analytical biochemistry 20100201
Effect of anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons in hypothalamic structures of C57Bl/6 mice involved in the food intake regulation.	Peptides 20100101
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases.	Journal of neural transmission (Vienna, Austria : 1996) 20100101
An integrated functional genomic study of acute phenobarbital exposure in the rat.	BMC genomics 20100101
Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes.	PloS one 20100101
5-Oxoproline (pyroglutamic) acidosis associated with chronic acetaminophen use.	Proceedings (Baylor University. Medical Center) 20100101
Benzothiadiazole and l-2-oxothiazolidine-4-carboxylic acid reduce the severity of Sharka symptoms in pea leaves: effect on antioxidative metabolism at the subcellular level.	Plant biology (Stuttgart, Germany) 20100101
[Severe metabolic acidosis as a result of 5-oxoproline in acetaminophen use].	Nederlands tijdschrift voor geneeskunde 20100101
Taurine in health and diseases: consistent evidence from experimental and epidemiological studies.	Journal of biomedical science 20100101
Procysteine increases alcohol-depleted glutathione stores in rat plantaris following a period of abstinence.	Alcohol and alcoholism (Oxford, Oxfordshire) 20100101
Metabolomic profiling of cellular responses to carvedilol enantiomers in vascular smooth muscle cells.	PloS one 20100101
Bioorganic synthesis of a recombinant HIV-1 fusion inhibitor, SC35EK, with an N-terminal pyroglutamate capping group.	Bioorganic & medicinal chemistry 20091201
Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement.	Journal of medicinal chemistry 20091126
From N-triisopropylsilylpyrrole to an optically active C-4 substituted pyroglutamic acid: total synthesis of penmacric acid.	Organic & biomolecular chemistry 20091107
Pidotimod promotes functional maturation of dendritic cells and displays adjuvant properties at the nasal mucosa level.	International immunopharmacology 20091101
Incorporation of N-amidino-pyroglutamic acid into peptides using intramolecular cyclization of alpha-guanidinoglutaric acid.	Journal of peptide science : an official publication of the European Peptide Society 20091101
Natural moisturizing factor components in the stratum corneum as biomarkers of filaggrin genotype: evaluation of minimally invasive methods.	The British journal of dermatology 20091101
4,4'-Bipyridine-pyroglutamic acid (1/2).	Acta crystallographica. Section E, Structure reports online 20091101
Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide.	Biochemical pharmacology 20091015
Glutathione modulation reverses the growth-promoting effect of growth factors, improving the 5-fluorouracil antitumour response in WiDr colon cancer cells.	Anticancer research 20091001
The protective effects of N-Acetl-cysteine, oxo-thiazolidine-carboxylate, acetaminophen and their combinations against sulfur mustard cytotoxicity on human skin fibroblast cell line (HF2FF).	Iranian biomedical journal 20091001
Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug l-2-oxothiazolidine-4-carboxylic acid.	Toxicology 20090919
Immunodominant epitope and properties of pyroglutamate-modified Abeta-specific antibodies produced in rabbits.	Journal of neuroimmunology 20090818
High-performance liquid chromatography-tandem mass spectrometry for the determination of pidotimod in human plasma and its application to a pharmacokinetic study.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090815
Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway.	Archives of biochemistry and biophysics 20090815
Procysteine stimulates expression of key anabolic factors and reduces plantaris atrophy in alcohol-fed rats.	Alcoholism, clinical and experimental research 20090801
Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis.	International journal of molecular medicine 20090801
Concise asymmetric synthesis of configurationally stable 4-trifluoromethyl thalidomide.	Future medicinal chemistry 20090801
Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides.	Biochemistry 20090728
L-2-Oxothiazolidine-4-carboxylate reverses glutathione oxidation and delays fatigue of skeletal muscle in vitro.	Journal of applied physiology (Bethesda, Md. : 1985) 20090701
Metabonomic study of ochratoxin a toxicity in rats after repeated administration: phenotypic anchoring enhances the ability for biomarker discovery.	Chemical research in toxicology 20090701
Pyroglutamic acid promotes survival of retinal ganglion cells after optic nerve injury.	Current eye research 20090701
Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence.	Endocrinology 20090501
Desflurane but not sevoflurane can increase lung resistance via tachykinin pathways.	British journal of anaesthesia 20090501
The orientation of BN-related peptides adsorbed on SERS-active silver nanoparticles: comparison with a silver electrode surface.	The journal of physical chemistry. B 20090409
Peptides of the adipokinetic hormone/red pigment-concentrating hormone family: a new take on biodiversity.	Annals of the New York Academy of Sciences 20090401
Gastric electrical stimulation for obesity: the need for a new device using wider pulses.	Obesity (Silver Spring, Md.) 20090301
Promising therapies in sickle cell disease.	Cardiovascular & hematological disorders drug targets 20090301
[Capsule metadoxine in the treatment of alcoholic liver disease: a randomized, double-blind, placebo-controlled, multicenter study].	Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20090301
Conversion of 4-oxoproline esters to 4-substituted pyrrole-2-carboxylic acid esters.	Chemical & pharmaceutical bulletin 20090201
NMDA receptor up-regulates pyroglutamyl peptidase II activity in the rat hippocampus.	Neuroscience letters 20090116
Anticoagulant and antithrombotic activity of a new peptide pENW (pGlu-Asn-Trp).	The Journal of pharmacy and pharmacology 20090101
Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes.	PloS one 20090101
A proteomic approach for studying insect phylogeny: CAPA peptides of ancient insect taxa (Dictyoptera, Blattoptera) as a test case.	BMC evolutionary biology 20090101
New therapeutic approach to Tourette Syndrome in children based on a randomized placebo-controlled double-blind phase IV study of the effectiveness and safety of magnesium and vitamin B6.	Trials 20090101
Pidotimod: a reappraisal.	International journal of immunopathology and pharmacology 20090101
NK1 receptor-mediated endothelium-dependent relaxation and contraction with different sensitivity to post-receptor signaling in pulmonary arteries.	Vascular pharmacology 20090101
Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish.	Neural development 20090101
[Non-alcoholic fatty liver disease: age peculiarities, breakthrough in pathogenetic therapy].	Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20090101
Pathophisiology of sickle cell disease and new drugs for the treatment.	Mediterranean journal of hematology and infectious diseases 20090101
Synthesis of highly substituted pyroglutamates via a domino Michael addition-Claisen rearrangement-lactamisation approach.	Organic & biomolecular chemistry 20081221
Acute alcohol intoxication.	European journal of internal medicine 20081201
Biological activity and identification of neuropeptides in the neurosecretory complexes of the cabbage pest insect, Mamestra brassicae (Noctuidae; Lepidoptera).	Acta biologica Hungarica 20081201
Synergistic immunostimulatory effect of pidotimod and red ginseng acidic polysaccharide on humoral immunity of immunosuppressed mice.	Die Pharmazie 20081201
Characterization of low-molecular-weight antiyeast metabolites produced by a food-protective Lactobacillus-Propionibacterium coculture.	Journal of food protection 20081201
Synthesis of the phosphinic analogue of thyrotropin releasing hormone.	The Journal of organic chemistry 20081107
Structural properties of bombesin-like peptides revealed by surface-enhanced Raman scattering on roughened silver electrodes.	Biopolymers 20081101
Anterior pituitary pyroglutamyl peptidase II activity controls TRH-induced prolactin release.	Peptides 20081101
Effect of hypomagnesemia on allogeneic activation in mice.	Transplant immunology 20081101
Stimulatory effects of bioamines norepinephrine and dopamine on locomotion of Pyrrhocoris apterus (L.): is the adipokinetic hormone involved?	Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20081101
A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis.	Plant physiology 20081101
Expression of lipid storage droplet protein-1 may define the role of AKH as a lipid mobilizing hormone in Manduca sexta.	Insect biochemistry and molecular biology 20081101
Participation of the cholinergic system in ameliorating effect of vasopressin fragment by group I metabotropic glutamate-receptor blockade.	Journal of pharmacological sciences 20081101
Antioxidant effects and insulin resistance improvement of chromium combined with vitamin C and e supplementation for type 2 diabetes mellitus.	Journal of clinical biochemistry and nutrition 20081101
Natural variation in plasticity of glucose homeostasis and food intake.	The Journal of experimental biology 20081001
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.	Nature medicine 20081001
Normal saline induces oxidative stress in peritoneal mesothelial cells.	Journal of pediatric surgery 20081001
Synergistic immunostimulating activity of pidotimod and red ginseng acidic polysaccharide against cyclophosphamide-induced immunosuppression.	Archives of pharmacal research 20080901
Guilty as charged: unmeasured urinary anions in a case of pyroglutamic acidosis.	The Netherlands journal of medicine 20080901
5-Oxoproline as a cause of high anion gap metabolic acidosis: an uncommon cause with common risk factors.	The Netherlands journal of medicine 20080901
Clinical applications of urinary organic acids. Part I: Detoxification markers.	Alternative medicine review : a journal of clinical therapeutic 20080901
Impact of cyclosporine A on magnesium homeostasis: clinical observation in lung transplant recipients and experimental study in mice.	Transplantation 20080815
Origins of gonadotropin-releasing hormone (GnRH) in vertebrates: identification of a novel GnRH in a basal vertebrate, the sea lamprey.	Endocrinology 20080801
Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.	Journal of neurochemistry 20080801
Prothyrotropin-releasing hormone targets its processing products to different vesicles of the secretory pathway.	The Journal of biological chemistry 20080718
Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta.	Biochemistry 20080715
Heterogeneity of monoclonal antibodies.	Journal of pharmaceutical sciences 20080701
Increased metal tolerance in Salix by nicotinamide and nicotinic acid.	Plant physiology and biochemistry : PPB 20080701
Analysis of glutamine, glutamate, pyroglutamate, and GABA in cerebrospinal fluid using ion pairing HPLC with positive electrospray LC/MS/MS.	Journal of neuroscience methods 20080630
Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26.	Journal of controlled release : official journal of the Controlled Release Society 20080604
Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration.	American journal of physiology. Heart and circulatory physiology 20080601
High throughput screening of bradykinin-potentiating peptides in Bothrops moojeni snake venom using precursor ion mass spectrometry.	Toxicon : official journal of the International Society on Toxinology 20080601
Neurokinin-3 peptide instead of neurokinin-1 synergistically exacerbates kainic acid-inducing degeneration of neurons in the substantia nigra of mice.	Journal of neurochemistry 20080401
Identification of putative crustacean neuropeptides using in silico analyses of publicly accessible expressed sequence tags.	General and comparative endocrinology 20080401
Structure of acostatin, a dimeric disintegrin from Southern copperhead (Agkistrodon contortrix contortrix), at 1.7 A resolution.	Acta crystallographica. Section D, Biological crystallography 20080401
Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling.	Cell metabolism 20080401
Rapid action of estrogens on intracellular calcium oscillations in primate luteinizing hormone-releasing hormone-1 neurons.	Endocrinology 20080301
Developmental regulation and functions of the expression of the neuropeptide corazonin in Drosophila melanogaster.	Cell and tissue research 20080301
A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndrome.	Critical care medicine 20080301
Differential response of TRHergic neurons of the hypothalamic paraventricular nucleus (PVN) in female animals submitted to food-restriction or dehydration-induced anorexia and cold exposure.	Hormones and behavior 20080201
Comparison of insect kinin analogs with cis-peptide bond, type VI-turn motifs identifies optimal stereochemistry for interaction with a recombinant arthropod kinin receptor from the southern cattle tick Boophilus microplus.	Peptides 20080201
Localization and thiol dependancy of endogenous nitro compounds-mediating urethral photo-relaxation.	Pflugers Archiv : European journal of physiology 20080101
Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia.	British journal of haematology 20080101
Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy.	Acta biochimica Polonica 20080101
Differentiation of Sclerotinia minor depends on thiol redox state and oxidative stress.	Canadian journal of microbiology 20080101
[Effects of an antiischemic drug combination and nimodipine on cerebral blood supply in a hemorrhagic stroke model in rats].	Eksperimental'naia i klinicheskaia farmakologiia 20080101
Contractile effect of tachykinins on Suncus murinus (house musk shrew) isolated ileum.	Neuropeptides 20080101
[Chemical constituents of Changium smyrnioides].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080101
Henoch-Schönlein purpura associated with pidotimod therapy.	Clinical and experimental rheumatology 20080101
Oxidant-induced atrogin-1 and transforming growth factor-beta1 precede alcohol-related myopathy in rats.	Muscle & nerve 20071201
Analysis of time-related metabolic fluctuations induced by ethionine in the rat.	Journal of proteome research 20071201
Identification of small molecules from human embryonic stem cells using metabolomics.	Stem cells and development 20071201
[Pyroglutamic acidemia associated with acetaminophen].	Anales de pediatria (Barcelona, Spain : 2003) 20071201
Diastereoselective synthesis of glutamate-appended oxolane rings: synthesis of (s)-(+)-lycoperdic acid.	The Journal of organic chemistry 20071123
Cytotoxicity of formaldehyde on human osteoblastic cells is related to intracellular glutathione levels.	Journal of biomedical materials research. Part B, Applied biomaterials 20071101
Mass spectrometric identification of pyroglutamic acid in peptides following selective hydrolysis.	Analytical biochemistry 20071101
Cold exposure increases the biosynthesis and proteolytic processing of prothyrotropin-releasing hormone in the hypothalamic paraventricular nucleus via beta-adrenoreceptors.	Endocrinology 20071001
The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on cisplatin-induced nephrotoxicity in rats.	Fundamental & clinical pharmacology 20071001
Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.	Biochemistry 20070925
Adipokinetic hormone-induced enhancement of antioxidant capacity of Pyrrhocoris apterus hemolymph in response to oxidative stress.	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20070901
Profound metabolic acidosis and oxoprolinuria in an adult.	Journal of medical toxicology : official journal of the American College of Medical Toxicology 20070901
Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity.	Chemico-biological interactions 20070830
Sequencing of T-superfamily conotoxins from Conus virgo: pyroglutamic acid identification and disulfide arrangement by MALDI mass spectrometry.	Journal of the American Society for Mass Spectrometry 20070801
Alveolar type II cells from ethanol-fed rats produce a fibronectin-enriched extracellular matrix that promotes monocyte activation.	Alcohol (Fayetteville, N.Y.) 20070801
High anion gap metabolic acidosis secondary to pyroglutamic aciduria (5-oxoprolinuria): association with prescription drugs and malnutrition.	Annals of clinical biochemistry 20070701
Water scorpions (Heteroptera, Nepidae) and giant water bugs (Heteroptera, Belostomatidae): sources of new members of the adipokinetic hormone/red pigment-concentrating hormone family.	Peptides 20070701
Crystal structures of two Bordetella pertussis periplasmic receptors contribute to defining a novel pyroglutamic acid binding DctP subfamily.	Journal of molecular biology 20070629
Therapy and clinical trials.	Current opinion in lipidology 20070601
Structure-based drug design of pyrrolidine-1, 2-dicarboxamides as a novel series of orally bioavailable factor Xa inhibitors.	Chemical biology & drug design 20070601
Magnesium as a preventive treatment for paediatric episodic tension-type headache: results at 1-year follow-up.	Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20070601
Inhibitory effect of cyclooxygenase inhibitors on the step-through passive avoidance performance in mice treated with NC-1900, an arginine-vasopressin fragment analog.	Methods and findings in experimental and clinical pharmacology 20070601
Expeditious access to unprotected racemic pyroglutamic acids.	The Journal of organic chemistry 20070511
Oxidative folding and N-terminal cyclization of onconase.	Biochemistry 20070508
Is the titer of adipokinetic peptides in Leptinotarsa decemlineata fed on genetically modified potatoes increased by oxidative stress?	Peptides 20070501
A novel two-domain architecture within the amino acid kinase enzyme family revealed by the crystal structure of Escherichia coli glutamate 5-kinase.	Journal of molecular biology 20070413
Quantification of urinary zwitterionic organic acids using weak-anion exchange chromatography with tandem MS detection.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401
Effects of a bacterial lipid byproduct on human pulp fibroblasts in vitro.	Journal of endodontics 20070401
Adipokines in children with sleep disordered breathing.	Sleep 20070401
Effect of NC-1900, an active fragment analog of arginine vasopressin, and inhibitors of arachidonic acid metabolism on performance of a passive avoidance task in mice.	European journal of pharmacology 20070329
Evidence for interplay between thyrotropin-releasing hormone (TRH) and its structural analogue pGlu-Glu-Pro-NH2 ([Glu2]TRH) in the brain: an in vivo microdialysis study.	Neuroscience letters 20070319
Structure design of multifunctional furoate and pyroglutamate esters of dextran by polymer-analogous reactions.	Macromolecular bioscience 20070308
A novel adipokinetic peptide in a water boatman (Heteroptera, Corixidae) and its bioanalogue in a saucer bug (Heteroptera, Naucoridae).	Peptides 20070301
5-Oxoproline reduces non-enzymatic antioxidant defenses in vitro in rat brain.	Metabolic brain disease 20070301
Effect of immunisation against gonadotrophin releasing hormone isoforms (mammalian GnRH-I, chicken GnRH-II and lamprey GnRH-III) on murine spermatogenesis.	Vaccine 20070301
Oxidative stress contributes to accelerated development of the senescent phenotype in human peritoneal mesothelial cells exposed to high glucose.	Free radical biology & medicine 20070301
Calcium movements during pigment aggregation in freshwater shrimp chromatophores.	Pigment cell research 20070201
Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions.	Biological chemistry 20070201
Pharmacokinetics of metadoxine for injection after repeated doses in healthy volunteers.	Chinese medical journal 20070120
An analog of thyrotropin-releasing hormone (TRH) is neuroprotective against glutamate-induced toxicity in fetal rat hippocampal neurons in vitro.	Brain research 20070112
Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism.	American journal of physiology. Endocrinology and metabolism 20070101
Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1.	Bioorganic & medicinal chemistry 20070101
Comparison of insect kinin analogs with cis-peptide bond motif 4-aminopyroglutamate identifies optimal stereochemistry for diuretic activity.	Biopolymers 20070101
Artificial elevation of glutathione affects symptom development in ZYMV-infected Cucurbita pepo L. plants.	Archives of virology 20070101
Structure-activity relationships for in vitro diuretic activity of CAP2b in the housefly.	Peptides 20070101
Urticaria due to calcium pidolate.	Allergologia et immunopathologia 20070101
Combinatorial solution-phase synthesis of (2S,4S)-4-acylamino-5-oxopyrrolidine-2-carboxamides.	Journal of combinatorial chemistry 20070101
Inborn errors in the metabolism of glutathione.	Orphanet journal of rare diseases 20070101
Acetaminophen-induced hepatotoxicity in a glutathione synthetase-deficient patient.	The Turkish journal of pediatrics 20070101
A semi-quantitative GeLC-MS analysis of temporal proteome expression in the emerging nosocomial pathogen Ochrobactrum anthropi.	Genome biology 20070101
Hair and amino acids: the interactions and the effects.	Journal of cosmetic science 20070101
Circadian rhythms of TRH-like peptide levels in rat brain.	Brain research 20061213
Brainstem thyrotropin-releasing hormone regulates food intake through vagal-dependent cholinergic stimulation of ghrelin secretion.	Endocrinology 20061201
Efficient asymmetric synthesis of novel 4-substituted and configurationally stable analogues of thalidomide.	Organic letters 20061123
Is lGnRH-III the most potent GnRH analog containing only natural amino acids that specifically inhibits the growth of human breast cancer cells?	Journal of peptide science : an official publication of the European Peptide Society 20061101
Unfolding of the immunoglobulin light and heavy chains is required for the enzymatic removal of N-terminal pyroglutamyl residues.	Biochimica et biophysica acta 20061101
Psychoneuroendocrinology of anorexia nervosa.	Psychoneuroendocrinology 20061101
On the seeding and oligomerization of pGlu-amyloid peptides (in vitro).	Biochemistry 20061017
Investigation of N-terminal glutamate cyclization of recombinant monoclonal antibody in formulation development.	Journal of pharmaceutical and biomedical analysis 20061011
Improvement of cationic albumin conjugated pegylated nanoparticles holding NC-1900, a vasopressin fragment analog, in memory deficits induced by scopolamine in mice.	Behavioural brain research 20061002
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.	Biochimica et biophysica acta 20061001
Effects of the tomato pathogen Fusarium oxysporum f. sp. radicis-lycopersici and of the biocontrol bacterium Pseudomonas fluorescens WCS365 on the composition of organic acids and sugars in tomato root exudate.	Molecular plant-microbe interactions : MPMI 20061001
Endocrine control of TAG lipase in the fat body of the migratory locust, Locusta migratoria.	Insect biochemistry and molecular biology 20061001
Occurrence of the free and Peptide forms of pyroglutamic acid in plasma from the portal blood of rats that had ingested a wheat gluten hydrolysate containing pyroglutamyl peptides.	Journal of agricultural and food chemistry 20060920
Prostanoids contribute to cutaneous active vasodilation in humans.	American journal of physiology. Regulatory, integrative and comparative physiology 20060901
An unusual cause of severe metabolic acidosis.	The Medical journal of Australia 20060821
Pyroglutamate stimulates Na+ -dependent glutamate transport across the blood-brain barrier.	FEBS letters 20060807
Cytomodulation of interleukin-2 effect by L-2-oxothiazolidine-4-carboxylate on human malignant melanoma.	Cancer immunology, immunotherapy : CII 20060801
Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury.	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060801
Persistent 5-oxoprolinuria with normal glutathione synthase and 5-oxoprolinase activities.	Journal of inherited metabolic disease 20060801
Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II. Insights into omega-versus aminopeptidase specificity in the M1 family.	The Journal of biological chemistry 20060707
Identification of dopamine, gonadotrophin-releasing hormone-I, and vasoactive intestinal peptide neurones activated by electrical stimulation to the medial preoptic area of the turkey hypothalamus: a potential reproductive neuroendocrine circuit.	Journal of neuroendocrinology 20060701
The role of tachykinins in circular muscle contractility of the murine ileum: a functional investigation.	Autonomic neuroscience : basic & clinical 20060630
An antioxidant modulates expression of receptor activator of NF-kappaB in asthma.	Experimental & molecular medicine 20060630
Capillary electrophoresis for caffeine and pyroglutamate determination in coffees study of the in vivo effect on learning and locomotor activity in mice.	Journal of pharmaceutical and biomedical analysis 20060616
Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis.	Journal of proteome research 20060601
Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid.	Chemical & pharmaceutical bulletin 20060601
Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene.	The Journal of neuroscience : the official journal of the Society for Neuroscience 20060503
Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin.	Endocrinology 20060501
Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion.	Diabetologia 20060501
Blood glucose lowering by means of lifestyle intervention has different effects on adipokines as compared with insulin treatment in subjects with type 2 diabetes.	Diabetologia 20060501
Microsphere-based protease assays and screening application for lethal factor and factor Xa.	Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Increased anion gap metabolic acidosis as a result of 5-oxoproline (pyroglutamic acid): a role for acetaminophen.	Clinical journal of the American Society of Nephrology : CJASN 20060501
Investigation of a route to ibotenic acid analogues via a reduced pyroglutamate template.	Organic & biomolecular chemistry 20060421
Differential receptor activation by cockroach adipokinetic hormones produces differential effects on ion currents, neuronal activity, and locomotion.	Journal of neurophysiology 20060401
Pathophysiologically based drug treatment of sickle cell disease.	Trends in pharmacological sciences 20060401
Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts.	Acta pharmacologica Sinica 20060401
Formation of pyroglutamic acid from N-terminal glutamic acid in immunoglobulin gamma antibodies.	Analytical chemistry 20060401
Red pigment concentrating hormone strongly enhances the strength of the feedback to the pyloric rhythm oscillator but has little effect on pyloric rhythm period.	Journal of neurophysiology 20060301
The detection of red pigment-concentrating hormone (RPCH) in crustacean eyestalk tissues using matrix-assisted laser desorption/ionization-Fourier transform mass spectrometry: [M + Na]+ ion formation in dried droplet tissue preparations.	Journal of mass spectrometry : JMS 20060301
CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts.	Clinica chimica acta; international journal of clinical chemistry 20060201
Impaired activity of the gamma-glutamyl cycle in nephropathic cystinosis fibroblasts.	Pediatric research 20060201
Antioxidants as novel agents for asthma.	Mini reviews in medicinal chemistry 20060201
Roles of N-terminal pyroglutamate in maintaining structural integrity and pKa values of catalytic histidine residues in bullfrog ribonuclease 3.	Journal of molecular biology 20060120
Disruption of disulfide bond formation alters the trafficking of prothyrotropin releasing hormone (proTRH)-derived peptides.	Regulatory peptides 20060115
Anatomy of the Hesse photoreceptor cell axonal system in the central nervous system of amphioxus.	The Journal of comparative neurology 20060101
New AZT conjugates as potent anti-HIV agents.	Nucleosides, nucleotides & nucleic acids 20060101
[Correlations of pharmacokinetics and pharmacodynamics of a combined preparation containing pyrrolidone and pyroglutamic acid].	Eksperimental'naia i klinicheskaia farmakologiia 20060101
Unmeasured anions in metabolic acidosis: unravelling the mystery.	Critical care (London, England) 20060101
Day-night differences in membrane-bound pyroglutamyl-2-naphthylamide-hydrolyzing activity in rat hypothalamus, pituitary, and retina.	Chronobiology international 20060101
Effect of pyrrolidone-pyroglutamic acid composition on blood flow in rat middle cerebral artery.	Bulletin of experimental biology and medicine 20060101
Effects of glutathione supplementation during peritoneal dialysis.	Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 20060101
Flight fuel and neuropeptidergic control of fuel mobilisation in the twig wilter, Holopterna alata (Hemiptera, Coreidae).	Journal of insect physiology 20060101
[AMPK, an active player in the control of metabolism].	Journal de la Societe de biologie 20060101
A follow up study on the efficacy of metadoxine in the treatment of alcohol dependence.	Substance abuse treatment, prevention, and policy 20060101
[Clinical trials of new therapeutic pharmacology for sickle cell disease].	Sante (Montrouge, France) 20060101
Altered glucose and insulin responses to brain medullary thyrotropin-releasing hormone (TRH)-induced autonomic activation in type 2 diabetic Goto-Kakizaki rats.	Endocrinology 20051201
Molecular mechanisms during sperm capacitation.	Human fertility (Cambridge, England) 20051201
Study of magnesium bioavailability from ten organic and inorganic Mg salts in Mg-depleted rats using a stable isotope approach.	Magnesium research 20051201
[Adipocytokins, obesity and development of type 2 diabetes].	Medecine sciences : M/S 20051201
An efficient synthesis of the constrained peptidomimetic 2-oxo-3-(N-9-fluorenyloxycarbonylamino)-1-azabicyclo[4.3.0]nonane-9-carboxylic acid from pyroglutamic acid.	The Journal of organic chemistry 20051125
[The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis].	Orvosi hetilap 20051120
Michael addition reactions between chiral equivalents of a nucleophilic glycine and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general method for efficient preparation of beta-substituted pyroglutamic acids. Case of topographically controlled stereoselectivity.	Journal of the American Chemical Society 20051102
Thyrotropin-releasing hormone in the dorsal vagal complex stimulates pancreatic blood flow in rats.	Regulatory peptides 20051101
A prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, regulates vascular permeability by reducing vascular endothelial growth factor expression in asthma.	Molecular pharmacology 20051101
Virucidal hand treatments for prevention of rhinovirus infection.	The Journal of antimicrobial chemotherapy 20051101
Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice.	European journal of pharmacology 20051017
Firing pattern and rapid modulation of activity by estrogen in primate luteinizing hormone releasing hormone-1 neurons.	Endocrinology 20051001
[Studies on chemical constituents in leaf of Isatis indigotica].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051001
Functional characterisation of tachykinin receptors in the circular muscle layer of the mouse ileum.	Regulatory peptides 20050915
Central thyrotropin-releasing hormone increases hepatic cyclic AMP through vagal-cholinergic and prostaglandin-dependent pathways in rats.	Peptides 20050901
Role of gastric mast cells in the regulation of central TRH analog-induced hyperemia in rats.	Peptides 20050901
NC-1900, an arginine-vasopressin analogue, ameliorates social behavior deficits and hyperlocomotion in MK-801-treated rats: therapeutic implications for schizophrenia.	Brain research 20050816
Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid.	Organic & biomolecular chemistry 20050807
Formation of extracellular glutamate from glutamine: exclusion of pyroglutamate as an intermediate.	Brain research 20050802
Factor XIa dimer in the activation of factor IX.	Biochemistry 20050802
Effect of neurokinin-1 receptor antagonists on serotoninergic, noradrenergic and hippocampal neurons: comparison with antidepressant drugs.	Peptides 20050801
Neuronal-glial plasticity in gonadotropin-releasing hormone release in adult female rats: role of the polysialylated form of the neural cell adhesion molecule.	The Journal of endocrinology 20050801
The removal of pyroglutamic acid from monoclonal antibodies without denaturation of the protein chains.	Analytical biochemistry 20050701
Recurrent high anion gap metabolic acidosis secondary to 5-oxoproline (pyroglutamic acid).	American journal of kidney diseases : the official journal of the National Kidney Foundation 20050701
Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital.	American journal of kidney diseases : the official journal of the National Kidney Foundation 20050701
Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes.	Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050701
Total synthesis of cyclic tetrapeptide FR235222, a potent immunosuppressant that inhibits mammalian histone deacetylases.	Organic letters 20050623
Substance P does not play a critical role in neurogenic inflammation in the rat masseter muscle.	Brain research 20050614
Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes.	Brain research. Molecular brain research 20050613
Urinary tract infection in children.	Clinical evidence 20050601
Synthesis of 3'-deoxy-3'-difluoromethyl azanucleosides from trans-4-hydroxy-l-proline.	The Journal of organic chemistry 20050513
The newly discovered insect order Mantophasmatodea contains a novel member of the adipokinetic hormone family of peptides.	Biochemical and biophysical research communications 20050506
Activation of triacylglycerol lipase in the fat body of a beetle by adipokinetic hormone.	Insect biochemistry and molecular biology 20050501
Glutamate antagonists attenuate the action of NC-1900, a vasopressin fragment analog, on passive avoidance task performance in mice.	Peptides 20050501
Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides.	Journal of natural products 20050501
Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation.	Cellular and molecular life sciences : CMLS 20050501
Chronic ethanol or glucose consumption alter TRH content and pyroglutamyl aminopeptidase II activity in rat limbic regions.	Regulatory peptides 20050415
Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection.	American journal of physiology. Lung cellular and molecular physiology 20050401
Quantification of cell-cycle distribution and mitotic index in Hydra by flow cytometry.	Cell proliferation 20050401
Application of stability-indicating HPTLC method for quantitative determination of metadoxine in pharmaceutical dosage form.	Farmaco (Societa chimica italiana : 1989) 20050401
Glutamatergic innervation of corticotropin-releasing hormone- and thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus of the rat.	Brain research 20050328
Air-stable Ir-(P-Phos) complex for highly enantioselective hydrogenation of quinolines and their immobilization in poly(ethylene glycol) dimethyl ether (DMPEG).	Chemical communications (Cambridge, England) 20050321
Straightforward ring expansion of pyroglutamates to perhydro-1,3-diazepine-2,4-diones.	Organic letters 20050317
Gln-tRNAGln formation from Glu-tRNAGln requires cooperation of an asparaginase and a Glu-tRNAGln kinase.	The Journal of biological chemistry 20050304
Preparation and reactivity of aminoacyl pyroglutamates. Facile synthesis of 10-membered-ring cyclic dipeptides derived from 1,4-diaminobutyric and glutamic acids.	Journal of peptide science : an official publication of the European Peptide Society 20050301
Importance of the central region of lamprey gonadotropin-releasing hormone III in the inhibition of breast cancer cell growth.	Peptides 20050301
Acute administration of alcohol modulates pyroglutamyl amino peptidase II activity and mRNA levels in rat limbic regions.	Neurochemistry international 20050301
A pyridinium-substituted analog of the TRH-like tripeptide pGlu-Glu-Pro-NH2 and its prodrugs as central nervous system agents.	Medicinal chemistry (Shariqah (United Arab Emirates)) 20050301
Degradation, insulin secretion, and antihyperglycemic actions of two palmitate-derivitized N-terminal pyroglutamyl analogues of glucose-dependent insulinotropic polypeptide.	Journal of medicinal chemistry 20050224
Protective effect of central thyrotropin-releasing hormone analog on cerulein-induced acute pancreatitis in rats.	Regulatory peptides 20050215
AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila.	American journal of physiology. Regulatory, integrative and comparative physiology 20050201
Evaluation of early gastric mucosal permeability induced by central thyrotropin-releasing hormone administration.	American journal of physiology. Gastrointestinal and liver physiology 20050201
A truncated isoform of pyroglutamyl aminopeptidase II produced by exon extension has dominant-negative activity.	Journal of neurochemistry 20050201
Magnesium as a treatment for paediatric tension-type headache: a clinical replication series.	Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20050201
First messenger regulation of mammalian sperm function via adenylyl cyclase/cAMP.	The Journal of reproduction and development 20050201
Severe hyperhomocysteinaemia and 5-oxoprolinuria secondary to antiproliferative and antimicrobial drug treatment.	Journal of inherited metabolic disease 20050101
Trial of erythropoietin treatment in a boy with glutathione synthetase deficiency.	Journal of inherited metabolic disease 20050101
[Role of metadoxyl in the treatment of the hepatotoxic effects of cytostatics].	Voprosy onkologii 20050101
An active insect kinin analog with 4-aminopyroglutamate, a novel cis-peptide bond, type VI beta-turn motif.	Biopolymers 20041205
Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats.	Psychopharmacology 20041201
Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041201
L-2-oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products.	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20041201
Endopeptidase activity of larval Lacanobia oleracea corpus allatum: metabolism of Manduca sexta allatostatin and allatotropin.	Archives of insect biochemistry and physiology 20041201
[Gluthathion synthetase deficit in a newborn infant].	Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20041101
Regulation of interleukin-6 expression by arecoline in human buccal mucosal fibroblasts is related to intracellular glutathione levels.	Oral diseases 20041101
Diastereoselective syntheses of deoxydysibetaine, dysibetaine, and its 4-epimer.	The Journal of organic chemistry 20041029
Alpha-tocopherol pro-vitamins: synthesis, hydrolysis and accumulation in rabbit ear skin.	Journal of controlled release : official journal of the Controlled Release Society 20041019
Further evidence on the anxiogenic-like effect of substance P evaluated in the elevated plus-maze in rats.	Behavioural brain research 20041005
Sequence and expression of the CAPA/CAP2b gene in the tobacco hawkmoth, Manduca sexta.	The Journal of experimental biology 20041001
Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells.	Nature 20040916
Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions.	Cancer science 20040901
Pyroglutamyl-asparagine amide normalizes long-term potentiation in rat hippocampal slices.	Bulletin of experimental biology and medicine 20040801
Virtually complete control of simple and face diastereoselectivity in the Michael addition reactions between achiral equivalents of a nucleophilic glycine and (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: practical method for preparation of beta-substituted pyroglutamic acids and prolines.	The Journal of organic chemistry 20040723
[Antioxidants in liver protection].	Orvosi hetilap 20040704
Facilitative effect of a novel AVP fragment analog, NC-1900, on memory retention and recall in mice.	Peptides 20040701
15Alpha-hydroxyprogesterone in male sea lampreys, Petromyzon marinus L.	Steroids 20040701
[Study on the mechanism of male reproductive toxicity of metadoxine in mice and rats].	Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20040701
Circadian rhythm of pigment migration induced by chromatrophorotropins in melanophores of the crab Chasmagnathus granulata.	Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20040701
Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease.	Neuroscience letters 20040617
Allosteric modification of factor XIa functional activity upon binding to polyanions.	Biochemistry 20040615
Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder.	The American journal of psychiatry 20040601
Effect of pretraining administration of NC-1900, a vasopressin fragment analog, on memory performance in non- or CO2-amnesic mice.	Pharmacology, biochemistry, and behavior 20040601
GABAergic basal forebrain neurons that express receptor for neurokinin B and send axons to the cerebral cortex.	The Journal of comparative neurology 20040517
Spawning and gamete follicle rupture in the cnidarian Renilla koellikeri: effects of putative neurohormones.	General and comparative endocrinology 20040515
Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster.	Genetics 20040501
Origin of diastereoselection in the hydrosilylation of chiral N-acyliminium intermediates derived from pyroglutamic acid.	Angewandte Chemie (International ed. in English) 20040426
Application of intramolecular enyne metathesis to the synthesis of aza[4.2.1]bicyclics: enantiospecific total synthesis of (+)-anatoxin-a.	Organic letters 20040415
15alpha-hydroxytestosterone induction by GnRH I and GnRH III in Atlantic and Great Lakes sea lamprey (Petromyzon marinus L.).	General and comparative endocrinology 20040401
The first total synthesis of a pyranonaphthoquinone antitumor, BE-54238B.	The Journal of antibiotics 20040401
Central administration of cocaine- and amphetamine-regulated transcript increases phosphorylation of cAMP response element binding protein in corticotropin-releasing hormone-producing neurons but not in prothyrotropin-releasing hormone-producing neurons in the hypothalamic paraventricular nucleus.	Brain research 20040305
Unexplained metabolic acidosis in critically ill patients: the role of pyroglutamic acid.	Intensive care medicine 20040301
Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery.	Biological & pharmaceutical bulletin 20040301
Human sperm responses to calcitonin, angiotensin II and fertilization-promoting peptide in prepared semen samples from normal donors and infertility patients.	Human reproduction (Oxford, England) 20040301
N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity.	The Journal of endocrinology 20040301
Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation-implications for immunological studies.	Molecular immunology 20040201
Toward the synthesis of pyroglutamate lauroyl ester: biocatalysis versus chemical catalysis.	Biotechnology letters 20040201
Purification of a specific inhibitor of pyroglutamyl aminopeptidase II from the marine annelide Hermodice carunculata. in vivo effects in rodent brain.	The international journal of biochemistry & cell biology 20040101
Regulation of intermediary metabolism and water balance of insects by neuropeptides.	Annual review of entomology 20040101
Pyroglutamyl aminopeptidase I, as a drug metabolizing enzyme, recognizes xenobiotic substrates containing L-2-oxothiazolidine-4-carboxylic acid.	Biological & pharmaceutical bulletin 20040101
Stimulatory effect of PG-KII, an NK3 tachykinin receptor agonist, on isolated pancreatic acini: species-related differences.	Peptides 20040101
Catalytic hydrogenation of glutamic acid.	Applied biochemistry and biotechnology 20040101
Evidence that lamprey GnRH-III does not release FSH selectively in cattle.	Reproduction (Cambridge, England) 20040101
A newborn infant with generalized glutathione synthetase deficiency.	The Turkish journal of pediatrics 20040101
The colon mitosis inhibitor pyroglutamyl-histidyl-glycine inhibits growth of non-tumorigenic colonic epithelial cells.	Anticancer research 20040101
Immune modulator pidotimod decreases the in vitro expression of CD30 in peripheral blood mononuclear cells of atopic asthmatic and normal children.	The Journal of asthma : official journal of the Association for the Care of Asthma 20040101
Pyroglutamyl-histidyl-glycine, the endogenous colon mitosis inhibitor, regulates cyclic AMP level in non-tumorigenic colonic epithelial cells.	Anticancer research 20040101
[Antioxidants-induced rearrangements of actin cytoskeleton in 3T3 and 3T3-SV40 fibroblasts].	Tsitologiia 20040101
3,3',5'-triiodo-L-thyronine reduces efficiency of mRNA knockdown by antisense oligodeoxynucleotides: a study with pyroglutamyl aminopeptidase II in adenohypophysis.	Oligonucleotides 20040101
Pressure/temperature combined treatments of precursors yield hormone-like peptides with pyroglutamate at the N terminus.	Journal of agricultural and food chemistry 20031231
Magnesium supplementation does not delay disease onset or increase survival in a mouse model of familial ALS.	Journal of the neurological sciences 20031215
First messenger regulation of capacitation via G protein-coupled mechanisms: a tale of serendipity and discovery.	Molecular human reproduction 20031201
Thyrotropin-releasing hormone in the dorsal vagal complex stimulates hepatic blood flow in rats.	Hepatology (Baltimore, Md.) 20031201
Sickle cell disease: from membrane pathophysiology to novel therapies for prevention of erythrocyte dehydration.	Journal of pediatric hematology/oncology 20031201
Characterization of a circulating N-extended form of the thyrotropin-releasing hormone-like peptide pGlu-Glu-Pro amide in human plasma.	The Journal of clinical endocrinology and metabolism 20031201
Substrate specificity of glutaminyl cyclases from plants and animals.	Biological chemistry 20031201
Effect of chirality on the structural behaviour of hydrogen-bonded n-alkylammonium pyroglutamates in the crystalline and smectic state.	Chemistry (Weinheim an der Bergstrasse, Germany) 20031107
Glucose acts in the CNS to regulate gastric motility during hypoglycemia.	American journal of physiology. Regulatory, integrative and comparative physiology 20031101
Hydrolysis of synthetic substrate, L-pyroglutamyl p-nitroanilide is catalyzed solely by pyroglutamyl aminopeptidase I in rat liver cytosol.	Biological & pharmaceutical bulletin 20031101
Chemoselective nucleophilic attack on N-acyl derivatives of (S)-ethyl 4,4-dimethyl pyroglutamate (DMPG).	Organic letters 20031016
Involvement of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic cytoprotection.	European journal of pharmacology 20031008
Adipokinetic hormone inhibits the formation of energy stores and egg production in the cricket Gryllus bimaculatus.	Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20031001
Intracellular mediators of granulysin-induced cell death.	Journal of immunology (Baltimore, Md. : 1950) 20030901
Peristalsis regulation by tachykinin NK1 receptors in the rabbit isolated distal colon.	American journal of physiology. Gastrointestinal and liver physiology 20030801

Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct.

The Journal of investigative dermatology 20140301

Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures.

PloS one 20140101

Five functional adipokinetic peptides expressed in the corpus cardiacum of the moth genus Hippotion (Lepidoptera, Sphingidae).

Regulatory peptides 20130610

Novel adipokinetic hormones in the kissing bugs Rhodnius prolixus, Triatoma infestans, Dipetalogaster maxima and Panstrongylus megistus.

Peptides 20130301

Modulation of airway epithelial cell functions by Pidotimod: NF-kB cytoplasmatic expression and its nuclear translocation are associated with an increased TLR-2 expression.

Italian journal of pediatrics 20130101

Energy-dependent modulation of glucagon-like signaling in Drosophila via the AMP-activated protein kinase.

Genetics 20121001

Serum metabolic signatures of fulminant type 1 diabetes.

Journal of proteome research 20120907

Composition and antimicrobial activity of fatty acids detected in the hygroscopic secretion collected from the secretory setae of larvae of the biting midge Forcipomyia nigra (Diptera: Ceratopogonidae).

Journal of insect physiology 20120901

Role of liquid chromatography-high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology.

Clinical toxicology (Philadelphia, Pa.) 20120901

Impact of filaggrin mutations on Raman spectra and biophysical properties of the stratum corneum in mild to moderate atopic dermatitis.

Journal of the European Academy of Dermatology and Venereology : JEADV 20120801

Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II.

Endocrinology 20120801

A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120716

Plant growth stimulation in Prunus species plantlets by BTH or OTC treatments under in vitro conditions.

Journal of plant physiology 20120715

Recombinant production of isotope-labeled peptides and spontaneous cyclization of amino-terminal glutamine into pyroglutamic acid.

Chembiochem : a European journal of chemical biology 20120709

5-oxoprolinemia causing elevated anion gap metabolic acidosis in the setting of acetaminophen use.

The Journal of emergency medicine 20120701

Pyroglutamyl peptidase II inhibition enhances the analeptic effect of thyrotropin-releasing hormone in the rat medial septum.

The Journal of pharmacology and experimental therapeutics 20120701

Structure-activity studies of Drosophila adipokinetic hormone (AKH) by a cellular expression system of dipteran AKH receptors.

General and comparative endocrinology 20120701

N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation.

Journal of neurochemistry 20120601

GnRH-III based multifunctional drug delivery systems containing daunorubicin and methotrexate.

European journal of medicinal chemistry 20120601

Molecular imaging of dementia.

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 20120601

Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats.

BMB reports 20120601

Gustatory perception and fat body energy metabolism are jointly affected by vitellogenin and juvenile hormone in honey bees.

PLoS genetics 20120601

Aggressive behavior and reproductive physiology in females of the social cichlid fish Cichlasoma dimerus.

Physiology & behavior 20120515

Rapid, simultaneous and nanomolar determination of pyroglutamic acid and cis-/trans-urocanic acid in human stratum corneum by hydrophilic interaction liquid chromatography (HILIC)-electrospray ionization tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120515

Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin.

Organic & biomolecular chemistry 20120507

Functional characterization of the adipokinetic hormone in the pea aphid, Acyrthosiphon pisum.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20120501

Decreased lactate and potassium levels in natural moisturizing factor from the stratum corneum of mild atopic dermatitis patients are involved with the reduced hydration state.

Journal of dermatological science 20120501

Italian guidelines for primary headaches: 2012 revised version.

The journal of headache and pain 20120501

New peptide pENW (pGlu-Asn-Trp) inhibits platelet activation by attenuating Akt phosphorylation.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120411

Chiral sensing using an achiral europium(III) complex by induced circularly polarized luminescence.

Inorganic chemistry 20120402

Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease.

The Journal of biological chemistry 20120309

Protective effect of a cysteine prodrug and antioxidant, L-2-oxothiazolidine-4-carboxylate, against ethanol-induced gastric lesions in rats.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120301

Sequencing and biological effects of an adipokinetic/hypertrehalosemic peptide in the stick insect, Baculum extradentatum.

Peptides 20120301

Active diuretic peptidomimetic insect kinin analogs that contain β-turn mimetic motif 4-aminopyroglutamate and lack native peptide bonds.

Peptides 20120301

Adipokinetic hormone-induced antioxidant response in Spodoptera littoralis.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20120301

Zinc l-pyrrolidone carboxylate inhibits the UVA-induced production of matrix metalloproteinase-1 by in vitro cultured skin fibroblasts, whereas it enhances their collagen synthesis.

International journal of cosmetic science 20120201

Role of brainstem thyrotropin-releasing hormone-triggered sympathetic overactivation in cardiovascular mortality in type 2 diabetic Goto-Kakizaki rats.

Hypertension research : official journal of the Japanese Society of Hypertension 20120201

Elevated cytokinin content in ipt transgenic creeping bentgrass promotes drought tolerance through regulating metabolite accumulation.

Journal of experimental botany 20120201

The retina is a target for GnRH-3 system in the European sea bass, Dicentrarchus labrax.

General and comparative endocrinology 20120201

Multiple strategies to prevent oxidative stress in Arabidopsis plants lacking the malate valve enzyme NADP-malate dehydrogenase.

Journal of experimental botany 20120201

Quantitative determination of pidotimod in human plasma by liquid chromatography tandem mass spectrometry: application to a bioequivalence study.

Arzneimittel-Forschung 20120201

Developing a comparative docking protocol for the prediction of peptide selectivity proﬁles: investigation of potassium channel toxins.

Toxins 20120201

A fluorescence-based microtiter plate assay for γ-glutamylcyclotransferase.

Analytical biochemistry 20120115

Two flushing-like reaction cases from calcium pidolate who tolerated calcium carbonate.

Allergologia et immunopathologia 20120101

Detection of peri-synaptic amyloid-β pyroglutamate aggregates in early stages of Alzheimer's disease and in AβPP transgenic mice using a novel monoclonal antibody.

Journal of Alzheimer's disease : JAD 20120101

Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect.

The Journal of investigative dermatology 20120101

The effect of adipokinetic hormone on midgut characteristics in Pyrrhocoris apterus L. (Heteroptera).

Journal of insect physiology 20120101

A distinct metabolic signature predicts development of fasting plasma glucose.

Journal of clinical bioinformatics 20120101

Glutathione homeostasis and functions: potential targets for medical interventions.

Journal of amino acids 20120101

Magnesium and vascular changes in hypertension.

International journal of hypertension 20120101

Metabolomics as a Hypothesis-Generating Functional Genomics Tool for the Annotation of Arabidopsis thaliana Genes of 'Unknown Function'.

Frontiers in plant science 20120101

Chronic acetaminophen ingestion resulting in severe anion gap metabolic acidosis secondary to 5-oxoproline accumulation: an under diagnosed phenomenon.

BMJ case reports 20120101

L-2-Oxothiazolidine-4-carboxylic acid or α-lipoic acid attenuates airway remodeling: involvement of nuclear factor-κB (NF-κB), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and hypoxia-inducible factor (HIF).

International journal of molecular sciences 20120101

Identification and functional characterization of two orphan G-protein-coupled receptors for adipokinetic hormones from silkworm Bombyx mori.

The Journal of biological chemistry 20111209

Neuroprotective effects of neurokinin receptor one in dopaminergic neurons are mediated through Akt/PKB cell signaling pathway.

Neuropharmacology 20111201

Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease.

Human psychopharmacology 20111201

[Study on the chemical constituents from the ethyl acetate extracts of Cremastra appendiculata].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20111201

Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core.

Neuroscience letters 20111114

Pyroglutamate amyloid-β (Aβ): a hatchet man in Alzheimer disease.

The Journal of biological chemistry 20111111

Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin.

The Journal of investigative dermatology 20111101

HPLC-MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium.

Journal of pharmaceutical and biomedical analysis 20111101

Cuts by caspase-14 control the proteolysis of filaggrin.

The Journal of investigative dermatology 20111101

An invertebrate [hydroxyproline]-modified neuropeptide: further evidence for a close evolutionary relationship between insect adipokinetic hormone and mammalian gonadotropin hormone family.

Biochemical and biophysical research communications 20111028

Spirocyclic systems derived from pyroglutamic acid.

Organic & biomolecular chemistry 20111021

A facile Cu(I)/BINAP-catalyzed asymmetric approach to functionalized pyroglutamate derivatives bearing a unique quaternary stereogenic center.

Organic letters 20111021

Recurrent anion gap metabolic acidosis in a woman with vertebral disc disease.

The American journal of emergency medicine 20111001

Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats.

Alcoholism, clinical and experimental research 20111001

Anti-diabetic effect of pyroglutamic acid in type 2 diabetic Goto-Kakizaki rats and KK-Ay mice.

The British journal of nutrition 20111001

Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase.

The Journal of endocrinology 20111001

Sexual dimorphism of gonadotropin-releasing hormone type-III (GnRH3) neurons and hormonal sex reversal of male reproductive behavior in Mozambique tilapia.

Zoological science 20111001

Two new compounds from the endophytic fungus Colletotrichum sp. L10 of Cephalotaxus hainanensis.

Journal of Asian natural products research 20111001

Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20110907

Influences of methamphetamine-induced acute intoxication on urinary and plasma metabolic profiles in the rat.

Toxicology 20110905

L-2-oxothiazolidine-4-carboxylate influence on age- and heat exposure-dependent redox changes in rat's blood plasma.

The journal of physiological sciences : JPS 20110901

Unveiling the roles of the glutathione redox system in vivo by analyzing genetically modified mice.

Journal of clinical biochemistry and nutrition 20110901

Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease.

Neurobiology of aging 20110801

Intraneuronal Aβ as a trigger for neuron loss: can this be translated into human pathology?

Biochemical Society transactions 20110801

Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4.

Bioconjugate chemistry 20110720

In vitro degradation and antitumor activity of oxime bond-linked daunorubicin-GnRH-III bioconjugates and DNA-binding properties of daunorubicin-amino acid metabolites.

Amino acids 20110701

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity.

Allergy 20110701

Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells.

Investigative ophthalmology & visual science 20110701

Expression of vesicular glutamate transporter-2.1 in medaka terminal nerve gonadotrophin-releasing hormone neurones.

Journal of neuroendocrinology 20110701

Application of gene targeting to designed mutation breeding of high-tryptophan rice.

Plant physiology 20110701

Angiotensin II type 1 receptor signaling regulates feeding behavior through anorexigenic corticotropin-releasing hormone in hypothalamus.

The Journal of biological chemistry 20110617

Synthesis of quaternary stereogenic centres via stereoselective intermolecular Friedel-Crafts reactions.

Organic & biomolecular chemistry 20110607

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms.

Acta neuropathologica 20110601

A GC/MS-based metabolomic approach for diagnosing citrin deficiency.

Analytical and bioanalytical chemistry 20110601

Water-in-oil-in-water double emulsions: an excellent delivery system for improving the oral bioavailability of pidotimod in rats.

Journal of pharmaceutical sciences 20110601

Self-double-emulsifying drug delivery system (SDEDDS): a new way for oral delivery of drugs with high solubility and low permeability.

International journal of pharmaceutics 20110516

Oxidative stress elicited by insecticides: a role for the adipokinetic hormone.

General and comparative endocrinology 20110515

Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteine.

American journal of respiratory cell and molecular biology 20110501

In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity.

Archives of toxicology 20110501

Brain-gut interactions between central vagal activation and abdominal surgery to influence gastric myenteric ganglia Fos expression in rats.

Peptides 20110501

Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.

The Journal of biological chemistry 20110422

N-terminal glutamate to pyroglutamate conversion in vivo for human IgG2 antibodies.

The Journal of biological chemistry 20110401

Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish.

Endocrinology 20110401

Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland.

Biochemical and biophysical research communications 20110401

Preparation and chiro-optical characterization of polyaniline doped with (+) or (-)-2-pyrrolidone-5-carboxylic acid (PCA).

Chirality 20110401

Temperature affects brain and pituitary gene expression related to reproduction and growth in the male blue gouramis, Trichogaster trichopterus.

Journal of experimental zoology. Part A, Ecological genetics and physiology 20110401

A sister group contrast using untargeted global metabolomic analysis delineates the biochemical regulation underlying desiccation tolerance in Sporobolus stapfianus.

The Plant cell 20110401

Novel methodologies for the synthesis of functionalized pyroglutamates.

Chemical communications (Cambridge, England) 20110321

The first decapeptide adipokinetic hormone (AKH) in Heteroptera: a novel AKH from a South African saucer bug, Laccocoris spurcus (Naucoridae, Laccocorinae).

Peptides 20110301

Non-invasive monitoring of L-2-oxothiazolidine-4-carboxylate metabolism in the rat brain by in vivo 13C magnetic resonance spectroscopy.

Neurochemical research 20110301

Chiral recognition at one-dimensional metal-organic coordination networks initiates the ordering of prochiral catalytic reagent methylacetoacetate on Au{111}.

Langmuir : the ACS journal of surfaces and colloids 20110301

Arginine-vasopressin V1a receptor inhibition improves neurologic outcomes following an intracerebral hemorrhagic brain injury.

Neurochemistry international 20110301

Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.

The Journal of biological chemistry 20110211

Mind the gap! An unusual metabolic acidosis.

Lancet (London, England) 20110205

Calcium and zinc complexes of pyrroglutamate analogs detected by electrospray ionization mass spectrometry.

Amino acids 20110201

Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status.

Chemico-biological interactions 20110201

Removal of N-terminal blocking groups from proteins.

Current protocols in protein science 20110201

[Role of the brain in the regulation of metabolism and energy expenditure: the central role of insulin, and insulin resistance of the brain].

Orvosi hetilap 20110116

Seasonal changes of brain GnRH-I, -II, and -III during the final reproductive period in adult male and female sea lamprey.

General and comparative endocrinology 20110115

A method for N-terminal de novo sequencing of Nα-blocked proteins by mass spectrometry.

The Analyst 20110107

The systemic inhibition of nitric oxide production rapidly regulates TRH mRNA concentration in the paraventricular nucleus of the hypothalamus and serum TSH concentration. Studies in control and cold-stressed rats.

Brain research 20110107

Compensatory expression and substrate inducibility of gamma-glutamyl transferase GGT2 isoform in Arabidopsis thaliana.

Journal of experimental botany 20110101

Luteinizing Hormone-Releasing Hormone (LHRH)-I antagonist cetrorelix inhibits myeloma cell growth in vitro and in vivo.

Molecular cancer therapeutics 20110101

The putative AKH receptor of the tobacco hornworm, Manduca sexta, and its expression.

Journal of insect science (Online) 20110101

Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound.

BMC chemical biology 20110101

NC1900, an arginine vasopressin analogue, fails to reduce brain edema and improve neurobehavioral deficits in an intracerebral hemorrhagic stroke mice model.

Acta neurochirurgica. Supplement 20110101

Isolation and identification of the umami enhancing compounds in Japanese soy sauce.

Bioscience, biotechnology, and biochemistry 20110101

Mn bioavailability by polarized Caco-2 cells: comparison between Mn gluconate and Mn oxyprolinate.

Nutrition journal 20110101

Renal mitochondrial cytopathies.

International journal of nephrology 20110101

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.

Molecular systems biology 20110101

Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites.

International journal of molecular sciences 20110101

[Dynamics of antipirin test at patients with alcoholic liver disease on the background of metadoksin drug receiving].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101

Prediction of protein modification sites of pyrrolidone carboxylic acid using mRMR feature selection and analysis.

PloS one 20110101

Pyroglutamic aciduria: a cause of high anion-gap metabolic acidosis associated with common drugs.

Irish medical journal 20110101

Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.

The Journal of biological chemistry 20101231

Cytotoxicity of dentine bonding agents on human pulp cells is related to intracellular glutathione levels.

International endodontic journal 20101201

Influence of synthetic lamprey GnRH-III on gonadotropin release and steroid hormone levels in gilts.

Theriogenology 20101201

Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in rats.

Peptides 20101201

Pyroglutamate-Aβ: role in the natural history of Alzheimer's disease.

The international journal of biochemistry & cell biology 20101201

Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus.

The Journal of allergy and clinical immunology 20101201

Signal transduction, plasma membrane calcium movements, and pigment translocation in freshwater shrimp chromatophores.

Journal of experimental zoology. Part A, Ecological genetics and physiology 20101101

A unified strategy targeting the thiodiketopiperazine mycotoxins exserohilone, gliotoxin, the epicoccins, the epicorazines, rostratin A and aranotin.

Chemistry (Weinheim an der Bergstrasse, Germany) 20101011

Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein.

Journal of medicinal chemistry 20100923

Zinc ions bind to and inhibit activated protein C.

Thrombosis and haemostasis 20100901

Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.

Bioorganic & medicinal chemistry letters 20100901

Oral magnesium supplementation improves vascular function in elderly diabetic patients.

Magnesium research 20100901

5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose.

The Journal of the American Osteopathic Association 20100901

Profound metabolic acidosis from pyroglutamic acidemia: an underappreciated cause of high anion gap metabolic acidosis.

CJEM 20100901

Potent hyperglycemic and hyperinsulinemic effects of thyrotropin-releasing hormone microinjected into the rostroventrolateral medulla and abnormal responses in type 2 diabetic rats.

Neuroscience 20100825

Complementary treatment with oral pidotimod plus vitamin C after laser vaporization for female genital warts: a prospective study.

Journal of medicine and life 20100815

Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease.

Acta neuropathologica 20100801

Characterization of intrathecally administered hemokinin-1-induced nociceptive behaviors in mice.

Peptides 20100801

Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of adefovir in human plasma and its application to a pharmacokinetic study.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100801

Adult Drosophila melanogaster as a model for the study of glucose homeostasis.

Aging 20100801

Negligible effect of oral garlic oil on the oral absorption of pyridoxine in metadoxine in rats.

Archives of pharmacal research 20100701

Role of late maternal thyroid hormones in cerebral cortex development: an experimental model for human prematurity.

Cerebral cortex (New York, N.Y. : 1991) 20100601

Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter.

Biochimica et biophysica acta 20100601

OXP1/YKL215c encodes an ATP-dependent 5-oxoprolinase in Saccharomyces cerevisiae: functional characterization, domain structure and identification of actin-like ATP-binding motifs in eukaryotic 5-oxoprolinases.

FEMS yeast research 20100601

Acute administration of 5-oxoproline induces oxidative damage to lipids and proteins and impairs antioxidant defenses in cerebral cortex and cerebellum of young rats.

Metabolic brain disease 20100601

Signal pathway of GnRH-III inhibiting FSH-induced steroidogenesis in granulosa cells.

Frontiers in bioscience (Elite edition) 20100601

A role of Histidine151 in the lamprey gonadotropin-releasing hormone receptor-1 (lGnRHR-1): Functional insight of diverse amino acid residues in the position of Tyr of the DRY motif in GnRHR from an ancestral type II receptor.

General and comparative endocrinology 20100501

Locust adipokinetic hormones mobilize diacylglycerols selectively.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20100501

Cytosolic action of phytochelatin synthase.

Plant physiology 20100501

Cytotoxicity of chlorhexidine on human osteoblastic cells is related to intracellular glutathione levels.

International endodontic journal 20100501

A second gene encodes the anti-diuretic hormone in the insect, Rhodnius prolixus.

Molecular and cellular endocrinology 20100412

Quantification of thyrotropin-releasing hormone by liquid chromatography-electrospray mass spectrometry.

Amino acids 20100401

A novel function of red pigment-concentrating hormone in crustaceans: Porcellio scaber (Isopoda) as a model species.

General and comparative endocrinology 20100401

Glutathione modulators reverse the pro-tumour effect of growth factors enhancing WiDr cell response to chemotherapeutic agents.

Anticancer research 20100401

Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism.

The Journal of biological chemistry 20100326

Synthesis of amino acid conjugates to 2-imino-3-methylene-5-carboxypyrrolidine and 2-imino-3-methylene-6-carboxypiperidine.

Bioorganic & medicinal chemistry letters 20100315

Nephrolithiasis related to inborn metabolic diseases.

Pediatric nephrology (Berlin, Germany) 20100301

Biological activity of the predicted red pigment-concentrating hormone of Daphnia pulex in a crustacean and an insect.

General and comparative endocrinology 20100301

A novel member of the adipokinetic peptide family in a 'living fossil', the ice crawler Galloisiana yuasai, is the first identified neuropeptide from the order Grylloblattodea.

Peptides 20100301

A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?

Journal of biosciences 20100301

Studies in serum support rapid formation of disulfide bond between unpaired cysteine residues in the VH domain of an immunoglobulin G1 molecule.

Analytical biochemistry 20100201

Effect of anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons in hypothalamic structures of C57Bl/6 mice involved in the food intake regulation.

Peptides 20100101

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases.

Journal of neural transmission (Vienna, Austria : 1996) 20100101

An integrated functional genomic study of acute phenobarbital exposure in the rat.

BMC genomics 20100101

Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes.

PloS one 20100101

5-Oxoproline (pyroglutamic) acidosis associated with chronic acetaminophen use.

Proceedings (Baylor University. Medical Center) 20100101

Benzothiadiazole and l-2-oxothiazolidine-4-carboxylic acid reduce the severity of Sharka symptoms in pea leaves: effect on antioxidative metabolism at the subcellular level.

Plant biology (Stuttgart, Germany) 20100101

[Severe metabolic acidosis as a result of 5-oxoproline in acetaminophen use].

Nederlands tijdschrift voor geneeskunde 20100101

Taurine in health and diseases: consistent evidence from experimental and epidemiological studies.

Journal of biomedical science 20100101

Procysteine increases alcohol-depleted glutathione stores in rat plantaris following a period of abstinence.

Alcohol and alcoholism (Oxford, Oxfordshire) 20100101

Metabolomic profiling of cellular responses to carvedilol enantiomers in vascular smooth muscle cells.

PloS one 20100101

Bioorganic synthesis of a recombinant HIV-1 fusion inhibitor, SC35EK, with an N-terminal pyroglutamate capping group.

Bioorganic & medicinal chemistry 20091201

Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement.

Journal of medicinal chemistry 20091126

From N-triisopropylsilylpyrrole to an optically active C-4 substituted pyroglutamic acid: total synthesis of penmacric acid.

Organic & biomolecular chemistry 20091107

Pidotimod promotes functional maturation of dendritic cells and displays adjuvant properties at the nasal mucosa level.

International immunopharmacology 20091101

Incorporation of N-amidino-pyroglutamic acid into peptides using intramolecular cyclization of alpha-guanidinoglutaric acid.

Journal of peptide science : an official publication of the European Peptide Society 20091101

Natural moisturizing factor components in the stratum corneum as biomarkers of filaggrin genotype: evaluation of minimally invasive methods.

The British journal of dermatology 20091101

4,4'-Bipyridine-pyroglutamic acid (1/2).

Acta crystallographica. Section E, Structure reports online 20091101

Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide.

Biochemical pharmacology 20091015

Glutathione modulation reverses the growth-promoting effect of growth factors, improving the 5-fluorouracil antitumour response in WiDr colon cancer cells.

Anticancer research 20091001

The protective effects of N-Acetl-cysteine, oxo-thiazolidine-carboxylate, acetaminophen and their combinations against sulfur mustard cytotoxicity on human skin fibroblast cell line (HF2FF).

Iranian biomedical journal 20091001

Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug l-2-oxothiazolidine-4-carboxylic acid.

Toxicology 20090919

Immunodominant epitope and properties of pyroglutamate-modified Abeta-specific antibodies produced in rabbits.

Journal of neuroimmunology 20090818

High-performance liquid chromatography-tandem mass spectrometry for the determination of pidotimod in human plasma and its application to a pharmacokinetic study.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090815

Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway.

Archives of biochemistry and biophysics 20090815

Procysteine stimulates expression of key anabolic factors and reduces plantaris atrophy in alcohol-fed rats.

Alcoholism, clinical and experimental research 20090801

Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis.

International journal of molecular medicine 20090801

Concise asymmetric synthesis of configurationally stable 4-trifluoromethyl thalidomide.

Future medicinal chemistry 20090801

Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides.

Biochemistry 20090728

L-2-Oxothiazolidine-4-carboxylate reverses glutathione oxidation and delays fatigue of skeletal muscle in vitro.

Journal of applied physiology (Bethesda, Md. : 1985) 20090701

Metabonomic study of ochratoxin a toxicity in rats after repeated administration: phenotypic anchoring enhances the ability for biomarker discovery.

Chemical research in toxicology 20090701

Pyroglutamic acid promotes survival of retinal ganglion cells after optic nerve injury.

Current eye research 20090701

Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence.

Endocrinology 20090501

Desflurane but not sevoflurane can increase lung resistance via tachykinin pathways.

British journal of anaesthesia 20090501

The orientation of BN-related peptides adsorbed on SERS-active silver nanoparticles: comparison with a silver electrode surface.

The journal of physical chemistry. B 20090409

Peptides of the adipokinetic hormone/red pigment-concentrating hormone family: a new take on biodiversity.

Annals of the New York Academy of Sciences 20090401

Gastric electrical stimulation for obesity: the need for a new device using wider pulses.

Obesity (Silver Spring, Md.) 20090301

Promising therapies in sickle cell disease.

Cardiovascular & hematological disorders drug targets 20090301

[Capsule metadoxine in the treatment of alcoholic liver disease: a randomized, double-blind, placebo-controlled, multicenter study].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20090301

Conversion of 4-oxoproline esters to 4-substituted pyrrole-2-carboxylic acid esters.

Chemical & pharmaceutical bulletin 20090201

NMDA receptor up-regulates pyroglutamyl peptidase II activity in the rat hippocampus.

Neuroscience letters 20090116

Anticoagulant and antithrombotic activity of a new peptide pENW (pGlu-Asn-Trp).

The Journal of pharmacy and pharmacology 20090101

Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes.

PloS one 20090101

A proteomic approach for studying insect phylogeny: CAPA peptides of ancient insect taxa (Dictyoptera, Blattoptera) as a test case.

BMC evolutionary biology 20090101

New therapeutic approach to Tourette Syndrome in children based on a randomized placebo-controlled double-blind phase IV study of the effectiveness and safety of magnesium and vitamin B6.

Trials 20090101

Pidotimod: a reappraisal.

International journal of immunopathology and pharmacology 20090101

NK1 receptor-mediated endothelium-dependent relaxation and contraction with different sensitivity to post-receptor signaling in pulmonary arteries.

Vascular pharmacology 20090101

Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish.

Neural development 20090101

[Non-alcoholic fatty liver disease: age peculiarities, breakthrough in pathogenetic therapy].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20090101

Pathophisiology of sickle cell disease and new drugs for the treatment.

Mediterranean journal of hematology and infectious diseases 20090101

Synthesis of highly substituted pyroglutamates via a domino Michael addition-Claisen rearrangement-lactamisation approach.

Organic & biomolecular chemistry 20081221

Acute alcohol intoxication.

European journal of internal medicine 20081201

Biological activity and identification of neuropeptides in the neurosecretory complexes of the cabbage pest insect, Mamestra brassicae (Noctuidae; Lepidoptera).

Acta biologica Hungarica 20081201

Synergistic immunostimulatory effect of pidotimod and red ginseng acidic polysaccharide on humoral immunity of immunosuppressed mice.

Die Pharmazie 20081201

Characterization of low-molecular-weight antiyeast metabolites produced by a food-protective Lactobacillus-Propionibacterium coculture.

Journal of food protection 20081201

Synthesis of the phosphinic analogue of thyrotropin releasing hormone.

The Journal of organic chemistry 20081107

Structural properties of bombesin-like peptides revealed by surface-enhanced Raman scattering on roughened silver electrodes.

Biopolymers 20081101

Anterior pituitary pyroglutamyl peptidase II activity controls TRH-induced prolactin release.

Peptides 20081101

Effect of hypomagnesemia on allogeneic activation in mice.

Transplant immunology 20081101

Stimulatory effects of bioamines norepinephrine and dopamine on locomotion of Pyrrhocoris apterus (L.): is the adipokinetic hormone involved?

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20081101

A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis.

Plant physiology 20081101

Expression of lipid storage droplet protein-1 may define the role of AKH as a lipid mobilizing hormone in Manduca sexta.

Insect biochemistry and molecular biology 20081101

Participation of the cholinergic system in ameliorating effect of vasopressin fragment by group I metabotropic glutamate-receptor blockade.

Journal of pharmacological sciences 20081101

Antioxidant effects and insulin resistance improvement of chromium combined with vitamin C and e supplementation for type 2 diabetes mellitus.

Journal of clinical biochemistry and nutrition 20081101

Natural variation in plasticity of glucose homeostasis and food intake.

The Journal of experimental biology 20081001

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.

Nature medicine 20081001

Normal saline induces oxidative stress in peritoneal mesothelial cells.

Journal of pediatric surgery 20081001

Synergistic immunostimulating activity of pidotimod and red ginseng acidic polysaccharide against cyclophosphamide-induced immunosuppression.

Archives of pharmacal research 20080901

Guilty as charged: unmeasured urinary anions in a case of pyroglutamic acidosis.

The Netherlands journal of medicine 20080901

5-Oxoproline as a cause of high anion gap metabolic acidosis: an uncommon cause with common risk factors.

The Netherlands journal of medicine 20080901

Clinical applications of urinary organic acids. Part I: Detoxification markers.

Alternative medicine review : a journal of clinical therapeutic 20080901

Impact of cyclosporine A on magnesium homeostasis: clinical observation in lung transplant recipients and experimental study in mice.

Transplantation 20080815

Origins of gonadotropin-releasing hormone (GnRH) in vertebrates: identification of a novel GnRH in a basal vertebrate, the sea lamprey.

Endocrinology 20080801

Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.

Journal of neurochemistry 20080801

Prothyrotropin-releasing hormone targets its processing products to different vesicles of the secretory pathway.

The Journal of biological chemistry 20080718

Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta.

Biochemistry 20080715

Heterogeneity of monoclonal antibodies.

Journal of pharmaceutical sciences 20080701

Increased metal tolerance in Salix by nicotinamide and nicotinic acid.

Plant physiology and biochemistry : PPB 20080701

Analysis of glutamine, glutamate, pyroglutamate, and GABA in cerebrospinal fluid using ion pairing HPLC with positive electrospray LC/MS/MS.

Journal of neuroscience methods 20080630

Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26.

Journal of controlled release : official journal of the Controlled Release Society 20080604

Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration.

American journal of physiology. Heart and circulatory physiology 20080601

High throughput screening of bradykinin-potentiating peptides in Bothrops moojeni snake venom using precursor ion mass spectrometry.

Toxicon : official journal of the International Society on Toxinology 20080601

Neurokinin-3 peptide instead of neurokinin-1 synergistically exacerbates kainic acid-inducing degeneration of neurons in the substantia nigra of mice.

Journal of neurochemistry 20080401

Identification of putative crustacean neuropeptides using in silico analyses of publicly accessible expressed sequence tags.

General and comparative endocrinology 20080401

Structure of acostatin, a dimeric disintegrin from Southern copperhead (Agkistrodon contortrix contortrix), at 1.7 A resolution.

Acta crystallographica. Section D, Biological crystallography 20080401

Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling.

Cell metabolism 20080401

Rapid action of estrogens on intracellular calcium oscillations in primate luteinizing hormone-releasing hormone-1 neurons.

Endocrinology 20080301

Developmental regulation and functions of the expression of the neuropeptide corazonin in Drosophila melanogaster.

Cell and tissue research 20080301

A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndrome.

Critical care medicine 20080301

Differential response of TRHergic neurons of the hypothalamic paraventricular nucleus (PVN) in female animals submitted to food-restriction or dehydration-induced anorexia and cold exposure.

Hormones and behavior 20080201

Comparison of insect kinin analogs with cis-peptide bond, type VI-turn motifs identifies optimal stereochemistry for interaction with a recombinant arthropod kinin receptor from the southern cattle tick Boophilus microplus.

Peptides 20080201

Localization and thiol dependancy of endogenous nitro compounds-mediating urethral photo-relaxation.

Pflugers Archiv : European journal of physiology 20080101

Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia.

British journal of haematology 20080101

Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy.

Acta biochimica Polonica 20080101

Differentiation of Sclerotinia minor depends on thiol redox state and oxidative stress.

Canadian journal of microbiology 20080101

[Effects of an antiischemic drug combination and nimodipine on cerebral blood supply in a hemorrhagic stroke model in rats].

Eksperimental'naia i klinicheskaia farmakologiia 20080101

Contractile effect of tachykinins on Suncus murinus (house musk shrew) isolated ileum.

Neuropeptides 20080101

[Chemical constituents of Changium smyrnioides].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080101

Henoch-Schönlein purpura associated with pidotimod therapy.

Clinical and experimental rheumatology 20080101

Oxidant-induced atrogin-1 and transforming growth factor-beta1 precede alcohol-related myopathy in rats.

Muscle & nerve 20071201

Analysis of time-related metabolic fluctuations induced by ethionine in the rat.

Journal of proteome research 20071201

Identification of small molecules from human embryonic stem cells using metabolomics.

Stem cells and development 20071201

[Pyroglutamic acidemia associated with acetaminophen].

Anales de pediatria (Barcelona, Spain : 2003) 20071201

Diastereoselective synthesis of glutamate-appended oxolane rings: synthesis of (s)-(+)-lycoperdic acid.

The Journal of organic chemistry 20071123

Cytotoxicity of formaldehyde on human osteoblastic cells is related to intracellular glutathione levels.

Journal of biomedical materials research. Part B, Applied biomaterials 20071101

Mass spectrometric identification of pyroglutamic acid in peptides following selective hydrolysis.

Analytical biochemistry 20071101

Cold exposure increases the biosynthesis and proteolytic processing of prothyrotropin-releasing hormone in the hypothalamic paraventricular nucleus via beta-adrenoreceptors.

Endocrinology 20071001

The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on cisplatin-induced nephrotoxicity in rats.

Fundamental & clinical pharmacology 20071001

Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.

Biochemistry 20070925

Adipokinetic hormone-induced enhancement of antioxidant capacity of Pyrrhocoris apterus hemolymph in response to oxidative stress.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20070901

Profound metabolic acidosis and oxoprolinuria in an adult.

Journal of medical toxicology : official journal of the American College of Medical Toxicology 20070901

Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity.

Chemico-biological interactions 20070830

Sequencing of T-superfamily conotoxins from Conus virgo: pyroglutamic acid identification and disulfide arrangement by MALDI mass spectrometry.

Journal of the American Society for Mass Spectrometry 20070801

Alveolar type II cells from ethanol-fed rats produce a fibronectin-enriched extracellular matrix that promotes monocyte activation.

Alcohol (Fayetteville, N.Y.) 20070801

High anion gap metabolic acidosis secondary to pyroglutamic aciduria (5-oxoprolinuria): association with prescription drugs and malnutrition.

Annals of clinical biochemistry 20070701

Water scorpions (Heteroptera, Nepidae) and giant water bugs (Heteroptera, Belostomatidae): sources of new members of the adipokinetic hormone/red pigment-concentrating hormone family.

Peptides 20070701

Crystal structures of two Bordetella pertussis periplasmic receptors contribute to defining a novel pyroglutamic acid binding DctP subfamily.

Journal of molecular biology 20070629

Therapy and clinical trials.

Current opinion in lipidology 20070601

Structure-based drug design of pyrrolidine-1, 2-dicarboxamides as a novel series of orally bioavailable factor Xa inhibitors.

Chemical biology & drug design 20070601

Magnesium as a preventive treatment for paediatric episodic tension-type headache: results at 1-year follow-up.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20070601

Inhibitory effect of cyclooxygenase inhibitors on the step-through passive avoidance performance in mice treated with NC-1900, an arginine-vasopressin fragment analog.

Methods and findings in experimental and clinical pharmacology 20070601

Expeditious access to unprotected racemic pyroglutamic acids.

The Journal of organic chemistry 20070511

Oxidative folding and N-terminal cyclization of onconase.

Biochemistry 20070508

Is the titer of adipokinetic peptides in Leptinotarsa decemlineata fed on genetically modified potatoes increased by oxidative stress?

Peptides 20070501

A novel two-domain architecture within the amino acid kinase enzyme family revealed by the crystal structure of Escherichia coli glutamate 5-kinase.

Journal of molecular biology 20070413

Quantification of urinary zwitterionic organic acids using weak-anion exchange chromatography with tandem MS detection.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401

Effects of a bacterial lipid byproduct on human pulp fibroblasts in vitro.

Journal of endodontics 20070401

Adipokines in children with sleep disordered breathing.

Sleep 20070401

Effect of NC-1900, an active fragment analog of arginine vasopressin, and inhibitors of arachidonic acid metabolism on performance of a passive avoidance task in mice.

European journal of pharmacology 20070329

Evidence for interplay between thyrotropin-releasing hormone (TRH) and its structural analogue pGlu-Glu-Pro-NH2 ([Glu2]TRH) in the brain: an in vivo microdialysis study.

Neuroscience letters 20070319

Structure design of multifunctional furoate and pyroglutamate esters of dextran by polymer-analogous reactions.

Macromolecular bioscience 20070308

A novel adipokinetic peptide in a water boatman (Heteroptera, Corixidae) and its bioanalogue in a saucer bug (Heteroptera, Naucoridae).

Peptides 20070301

5-Oxoproline reduces non-enzymatic antioxidant defenses in vitro in rat brain.

Metabolic brain disease 20070301

Effect of immunisation against gonadotrophin releasing hormone isoforms (mammalian GnRH-I, chicken GnRH-II and lamprey GnRH-III) on murine spermatogenesis.

Vaccine 20070301

Oxidative stress contributes to accelerated development of the senescent phenotype in human peritoneal mesothelial cells exposed to high glucose.

Free radical biology & medicine 20070301

Calcium movements during pigment aggregation in freshwater shrimp chromatophores.

Pigment cell research 20070201

Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions.

Biological chemistry 20070201

Pharmacokinetics of metadoxine for injection after repeated doses in healthy volunteers.

Chinese medical journal 20070120

An analog of thyrotropin-releasing hormone (TRH) is neuroprotective against glutamate-induced toxicity in fetal rat hippocampal neurons in vitro.

Brain research 20070112

Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism.

American journal of physiology. Endocrinology and metabolism 20070101

Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1.

Bioorganic & medicinal chemistry 20070101

Comparison of insect kinin analogs with cis-peptide bond motif 4-aminopyroglutamate identifies optimal stereochemistry for diuretic activity.

Biopolymers 20070101

Artificial elevation of glutathione affects symptom development in ZYMV-infected Cucurbita pepo L. plants.

Archives of virology 20070101

Structure-activity relationships for in vitro diuretic activity of CAP2b in the housefly.

Peptides 20070101

Urticaria due to calcium pidolate.

Allergologia et immunopathologia 20070101

Combinatorial solution-phase synthesis of (2S,4S)-4-acylamino-5-oxopyrrolidine-2-carboxamides.

Journal of combinatorial chemistry 20070101

Inborn errors in the metabolism of glutathione.

Orphanet journal of rare diseases 20070101

Acetaminophen-induced hepatotoxicity in a glutathione synthetase-deficient patient.

The Turkish journal of pediatrics 20070101

A semi-quantitative GeLC-MS analysis of temporal proteome expression in the emerging nosocomial pathogen Ochrobactrum anthropi.

Genome biology 20070101

Hair and amino acids: the interactions and the effects.

Journal of cosmetic science 20070101

Circadian rhythms of TRH-like peptide levels in rat brain.

Brain research 20061213

Brainstem thyrotropin-releasing hormone regulates food intake through vagal-dependent cholinergic stimulation of ghrelin secretion.

Endocrinology 20061201

Efficient asymmetric synthesis of novel 4-substituted and configurationally stable analogues of thalidomide.

Organic letters 20061123

Is lGnRH-III the most potent GnRH analog containing only natural amino acids that specifically inhibits the growth of human breast cancer cells?

Journal of peptide science : an official publication of the European Peptide Society 20061101

Unfolding of the immunoglobulin light and heavy chains is required for the enzymatic removal of N-terminal pyroglutamyl residues.

Biochimica et biophysica acta 20061101

Psychoneuroendocrinology of anorexia nervosa.

Psychoneuroendocrinology 20061101

On the seeding and oligomerization of pGlu-amyloid peptides (in vitro).

Biochemistry 20061017

Investigation of N-terminal glutamate cyclization of recombinant monoclonal antibody in formulation development.

Journal of pharmaceutical and biomedical analysis 20061011

Improvement of cationic albumin conjugated pegylated nanoparticles holding NC-1900, a vasopressin fragment analog, in memory deficits induced by scopolamine in mice.

Behavioural brain research 20061002

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.

Biochimica et biophysica acta 20061001

Effects of the tomato pathogen Fusarium oxysporum f. sp. radicis-lycopersici and of the biocontrol bacterium Pseudomonas fluorescens WCS365 on the composition of organic acids and sugars in tomato root exudate.

Molecular plant-microbe interactions : MPMI 20061001

Endocrine control of TAG lipase in the fat body of the migratory locust, Locusta migratoria.

Insect biochemistry and molecular biology 20061001

Occurrence of the free and Peptide forms of pyroglutamic acid in plasma from the portal blood of rats that had ingested a wheat gluten hydrolysate containing pyroglutamyl peptides.

Journal of agricultural and food chemistry 20060920

Prostanoids contribute to cutaneous active vasodilation in humans.

American journal of physiology. Regulatory, integrative and comparative physiology 20060901

An unusual cause of severe metabolic acidosis.

The Medical journal of Australia 20060821

Pyroglutamate stimulates Na+ -dependent glutamate transport across the blood-brain barrier.

FEBS letters 20060807

Cytomodulation of interleukin-2 effect by L-2-oxothiazolidine-4-carboxylate on human malignant melanoma.

Cancer immunology, immunotherapy : CII 20060801

Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060801

Persistent 5-oxoprolinuria with normal glutathione synthase and 5-oxoprolinase activities.

Journal of inherited metabolic disease 20060801

Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II. Insights into omega-versus aminopeptidase specificity in the M1 family.

The Journal of biological chemistry 20060707

Identification of dopamine, gonadotrophin-releasing hormone-I, and vasoactive intestinal peptide neurones activated by electrical stimulation to the medial preoptic area of the turkey hypothalamus: a potential reproductive neuroendocrine circuit.

Journal of neuroendocrinology 20060701

The role of tachykinins in circular muscle contractility of the murine ileum: a functional investigation.

Autonomic neuroscience : basic & clinical 20060630

An antioxidant modulates expression of receptor activator of NF-kappaB in asthma.

Experimental & molecular medicine 20060630

Capillary electrophoresis for caffeine and pyroglutamate determination in coffees study of the in vivo effect on learning and locomotor activity in mice.

Journal of pharmaceutical and biomedical analysis 20060616

Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis.

Journal of proteome research 20060601

Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid.

Chemical & pharmaceutical bulletin 20060601

Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20060503

Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin.

Endocrinology 20060501

Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion.

Diabetologia 20060501

Blood glucose lowering by means of lifestyle intervention has different effects on adipokines as compared with insulin treatment in subjects with type 2 diabetes.

Diabetologia 20060501

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Increased anion gap metabolic acidosis as a result of 5-oxoproline (pyroglutamic acid): a role for acetaminophen.

Clinical journal of the American Society of Nephrology : CJASN 20060501

Investigation of a route to ibotenic acid analogues via a reduced pyroglutamate template.

Organic & biomolecular chemistry 20060421

Differential receptor activation by cockroach adipokinetic hormones produces differential effects on ion currents, neuronal activity, and locomotion.

Journal of neurophysiology 20060401

Pathophysiologically based drug treatment of sickle cell disease.

Trends in pharmacological sciences 20060401

Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts.

Acta pharmacologica Sinica 20060401

Formation of pyroglutamic acid from N-terminal glutamic acid in immunoglobulin gamma antibodies.

Analytical chemistry 20060401

Red pigment concentrating hormone strongly enhances the strength of the feedback to the pyloric rhythm oscillator but has little effect on pyloric rhythm period.

Journal of neurophysiology 20060301

The detection of red pigment-concentrating hormone (RPCH) in crustacean eyestalk tissues using matrix-assisted laser desorption/ionization-Fourier transform mass spectrometry: [M + Na]+ ion formation in dried droplet tissue preparations.

Journal of mass spectrometry : JMS 20060301

CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts.

Clinica chimica acta; international journal of clinical chemistry 20060201

Impaired activity of the gamma-glutamyl cycle in nephropathic cystinosis fibroblasts.

Pediatric research 20060201

Antioxidants as novel agents for asthma.

Mini reviews in medicinal chemistry 20060201

Roles of N-terminal pyroglutamate in maintaining structural integrity and pKa values of catalytic histidine residues in bullfrog ribonuclease 3.

Journal of molecular biology 20060120

Disruption of disulfide bond formation alters the trafficking of prothyrotropin releasing hormone (proTRH)-derived peptides.

Regulatory peptides 20060115

Anatomy of the Hesse photoreceptor cell axonal system in the central nervous system of amphioxus.

The Journal of comparative neurology 20060101

New AZT conjugates as potent anti-HIV agents.

Nucleosides, nucleotides & nucleic acids 20060101

[Correlations of pharmacokinetics and pharmacodynamics of a combined preparation containing pyrrolidone and pyroglutamic acid].

Eksperimental'naia i klinicheskaia farmakologiia 20060101

Unmeasured anions in metabolic acidosis: unravelling the mystery.

Critical care (London, England) 20060101

Day-night differences in membrane-bound pyroglutamyl-2-naphthylamide-hydrolyzing activity in rat hypothalamus, pituitary, and retina.

Chronobiology international 20060101

Effect of pyrrolidone-pyroglutamic acid composition on blood flow in rat middle cerebral artery.

Bulletin of experimental biology and medicine 20060101

Effects of glutathione supplementation during peritoneal dialysis.

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 20060101

Flight fuel and neuropeptidergic control of fuel mobilisation in the twig wilter, Holopterna alata (Hemiptera, Coreidae).

Journal of insect physiology 20060101

[AMPK, an active player in the control of metabolism].

Journal de la Societe de biologie 20060101

A follow up study on the efficacy of metadoxine in the treatment of alcohol dependence.

Substance abuse treatment, prevention, and policy 20060101

[Clinical trials of new therapeutic pharmacology for sickle cell disease].

Sante (Montrouge, France) 20060101

Altered glucose and insulin responses to brain medullary thyrotropin-releasing hormone (TRH)-induced autonomic activation in type 2 diabetic Goto-Kakizaki rats.

Endocrinology 20051201

Molecular mechanisms during sperm capacitation.

Human fertility (Cambridge, England) 20051201

Study of magnesium bioavailability from ten organic and inorganic Mg salts in Mg-depleted rats using a stable isotope approach.

Magnesium research 20051201

[Adipocytokins, obesity and development of type 2 diabetes].

Medecine sciences : M/S 20051201

An efficient synthesis of the constrained peptidomimetic 2-oxo-3-(N-9-fluorenyloxycarbonylamino)-1-azabicyclo[4.3.0]nonane-9-carboxylic acid from pyroglutamic acid.

The Journal of organic chemistry 20051125

[The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis].

Orvosi hetilap 20051120

Michael addition reactions between chiral equivalents of a nucleophilic glycine and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general method for efficient preparation of beta-substituted pyroglutamic acids. Case of topographically controlled stereoselectivity.

Journal of the American Chemical Society 20051102

Thyrotropin-releasing hormone in the dorsal vagal complex stimulates pancreatic blood flow in rats.

Regulatory peptides 20051101

A prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, regulates vascular permeability by reducing vascular endothelial growth factor expression in asthma.

Molecular pharmacology 20051101

Virucidal hand treatments for prevention of rhinovirus infection.

The Journal of antimicrobial chemotherapy 20051101

Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice.

European journal of pharmacology 20051017

Firing pattern and rapid modulation of activity by estrogen in primate luteinizing hormone releasing hormone-1 neurons.

Endocrinology 20051001

[Studies on chemical constituents in leaf of Isatis indigotica].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051001

Functional characterisation of tachykinin receptors in the circular muscle layer of the mouse ileum.

Regulatory peptides 20050915

Central thyrotropin-releasing hormone increases hepatic cyclic AMP through vagal-cholinergic and prostaglandin-dependent pathways in rats.

Peptides 20050901

Role of gastric mast cells in the regulation of central TRH analog-induced hyperemia in rats.

Peptides 20050901

NC-1900, an arginine-vasopressin analogue, ameliorates social behavior deficits and hyperlocomotion in MK-801-treated rats: therapeutic implications for schizophrenia.

Brain research 20050816

Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid.

Organic & biomolecular chemistry 20050807

Formation of extracellular glutamate from glutamine: exclusion of pyroglutamate as an intermediate.

Brain research 20050802

Factor XIa dimer in the activation of factor IX.

Biochemistry 20050802

Effect of neurokinin-1 receptor antagonists on serotoninergic, noradrenergic and hippocampal neurons: comparison with antidepressant drugs.

Peptides 20050801

Neuronal-glial plasticity in gonadotropin-releasing hormone release in adult female rats: role of the polysialylated form of the neural cell adhesion molecule.

The Journal of endocrinology 20050801

The removal of pyroglutamic acid from monoclonal antibodies without denaturation of the protein chains.

Analytical biochemistry 20050701

Recurrent high anion gap metabolic acidosis secondary to 5-oxoproline (pyroglutamic acid).

American journal of kidney diseases : the official journal of the National Kidney Foundation 20050701

Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital.

American journal of kidney diseases : the official journal of the National Kidney Foundation 20050701

Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050701

Total synthesis of cyclic tetrapeptide FR235222, a potent immunosuppressant that inhibits mammalian histone deacetylases.

Organic letters 20050623

Substance P does not play a critical role in neurogenic inflammation in the rat masseter muscle.

Brain research 20050614

Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes.

Brain research. Molecular brain research 20050613

Urinary tract infection in children.

Clinical evidence 20050601

Synthesis of 3'-deoxy-3'-difluoromethyl azanucleosides from trans-4-hydroxy-l-proline.

The Journal of organic chemistry 20050513

The newly discovered insect order Mantophasmatodea contains a novel member of the adipokinetic hormone family of peptides.

Biochemical and biophysical research communications 20050506

Activation of triacylglycerol lipase in the fat body of a beetle by adipokinetic hormone.

Insect biochemistry and molecular biology 20050501

Glutamate antagonists attenuate the action of NC-1900, a vasopressin fragment analog, on passive avoidance task performance in mice.

Peptides 20050501

Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides.

Journal of natural products 20050501

Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation.

Cellular and molecular life sciences : CMLS 20050501

Chronic ethanol or glucose consumption alter TRH content and pyroglutamyl aminopeptidase II activity in rat limbic regions.

Regulatory peptides 20050415

Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection.

American journal of physiology. Lung cellular and molecular physiology 20050401

Quantification of cell-cycle distribution and mitotic index in Hydra by flow cytometry.

Cell proliferation 20050401

Application of stability-indicating HPTLC method for quantitative determination of metadoxine in pharmaceutical dosage form.

Farmaco (Societa chimica italiana : 1989) 20050401

Glutamatergic innervation of corticotropin-releasing hormone- and thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus of the rat.

Brain research 20050328

Air-stable Ir-(P-Phos) complex for highly enantioselective hydrogenation of quinolines and their immobilization in poly(ethylene glycol) dimethyl ether (DMPEG).

Chemical communications (Cambridge, England) 20050321

Straightforward ring expansion of pyroglutamates to perhydro-1,3-diazepine-2,4-diones.

Organic letters 20050317

Gln-tRNAGln formation from Glu-tRNAGln requires cooperation of an asparaginase and a Glu-tRNAGln kinase.

The Journal of biological chemistry 20050304

Preparation and reactivity of aminoacyl pyroglutamates. Facile synthesis of 10-membered-ring cyclic dipeptides derived from 1,4-diaminobutyric and glutamic acids.

Journal of peptide science : an official publication of the European Peptide Society 20050301

Importance of the central region of lamprey gonadotropin-releasing hormone III in the inhibition of breast cancer cell growth.

Peptides 20050301

Acute administration of alcohol modulates pyroglutamyl amino peptidase II activity and mRNA levels in rat limbic regions.

Neurochemistry international 20050301

A pyridinium-substituted analog of the TRH-like tripeptide pGlu-Glu-Pro-NH2 and its prodrugs as central nervous system agents.

Medicinal chemistry (Shariqah (United Arab Emirates)) 20050301

Degradation, insulin secretion, and antihyperglycemic actions of two palmitate-derivitized N-terminal pyroglutamyl analogues of glucose-dependent insulinotropic polypeptide.

Journal of medicinal chemistry 20050224

Protective effect of central thyrotropin-releasing hormone analog on cerulein-induced acute pancreatitis in rats.

Regulatory peptides 20050215

AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila.

American journal of physiology. Regulatory, integrative and comparative physiology 20050201

Evaluation of early gastric mucosal permeability induced by central thyrotropin-releasing hormone administration.

American journal of physiology. Gastrointestinal and liver physiology 20050201

A truncated isoform of pyroglutamyl aminopeptidase II produced by exon extension has dominant-negative activity.

Journal of neurochemistry 20050201

Magnesium as a treatment for paediatric tension-type headache: a clinical replication series.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20050201

First messenger regulation of mammalian sperm function via adenylyl cyclase/cAMP.

The Journal of reproduction and development 20050201

Severe hyperhomocysteinaemia and 5-oxoprolinuria secondary to antiproliferative and antimicrobial drug treatment.

Journal of inherited metabolic disease 20050101

Trial of erythropoietin treatment in a boy with glutathione synthetase deficiency.

Journal of inherited metabolic disease 20050101

[Role of metadoxyl in the treatment of the hepatotoxic effects of cytostatics].

Voprosy onkologii 20050101

An active insect kinin analog with 4-aminopyroglutamate, a novel cis-peptide bond, type VI beta-turn motif.

Biopolymers 20041205

Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats.

Psychopharmacology 20041201

Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041201

L-2-oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20041201

Endopeptidase activity of larval Lacanobia oleracea corpus allatum: metabolism of Manduca sexta allatostatin and allatotropin.

Archives of insect biochemistry and physiology 20041201

[Gluthathion synthetase deficit in a newborn infant].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20041101

Regulation of interleukin-6 expression by arecoline in human buccal mucosal fibroblasts is related to intracellular glutathione levels.

Oral diseases 20041101

Diastereoselective syntheses of deoxydysibetaine, dysibetaine, and its 4-epimer.

The Journal of organic chemistry 20041029

Alpha-tocopherol pro-vitamins: synthesis, hydrolysis and accumulation in rabbit ear skin.

Journal of controlled release : official journal of the Controlled Release Society 20041019

Further evidence on the anxiogenic-like effect of substance P evaluated in the elevated plus-maze in rats.

Behavioural brain research 20041005

Sequence and expression of the CAPA/CAP2b gene in the tobacco hawkmoth, Manduca sexta.

The Journal of experimental biology 20041001

Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells.

Nature 20040916

Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions.

Cancer science 20040901

Pyroglutamyl-asparagine amide normalizes long-term potentiation in rat hippocampal slices.

Bulletin of experimental biology and medicine 20040801

Virtually complete control of simple and face diastereoselectivity in the Michael addition reactions between achiral equivalents of a nucleophilic glycine and (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: practical method for preparation of beta-substituted pyroglutamic acids and prolines.

The Journal of organic chemistry 20040723

[Antioxidants in liver protection].

Orvosi hetilap 20040704

Facilitative effect of a novel AVP fragment analog, NC-1900, on memory retention and recall in mice.

Peptides 20040701

15Alpha-hydroxyprogesterone in male sea lampreys, Petromyzon marinus L.

Steroids 20040701

[Study on the mechanism of male reproductive toxicity of metadoxine in mice and rats].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20040701

Circadian rhythm of pigment migration induced by chromatrophorotropins in melanophores of the crab Chasmagnathus granulata.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20040701

Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease.

Neuroscience letters 20040617

Allosteric modification of factor XIa functional activity upon binding to polyanions.

Biochemistry 20040615

Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder.

The American journal of psychiatry 20040601

Effect of pretraining administration of NC-1900, a vasopressin fragment analog, on memory performance in non- or CO2-amnesic mice.

Pharmacology, biochemistry, and behavior 20040601

GABAergic basal forebrain neurons that express receptor for neurokinin B and send axons to the cerebral cortex.

The Journal of comparative neurology 20040517

Spawning and gamete follicle rupture in the cnidarian Renilla koellikeri: effects of putative neurohormones.

General and comparative endocrinology 20040515

Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster.

Genetics 20040501

Origin of diastereoselection in the hydrosilylation of chiral N-acyliminium intermediates derived from pyroglutamic acid.

Angewandte Chemie (International ed. in English) 20040426

Application of intramolecular enyne metathesis to the synthesis of aza[4.2.1]bicyclics: enantiospecific total synthesis of (+)-anatoxin-a.

Organic letters 20040415

15alpha-hydroxytestosterone induction by GnRH I and GnRH III in Atlantic and Great Lakes sea lamprey (Petromyzon marinus L.).

General and comparative endocrinology 20040401

The first total synthesis of a pyranonaphthoquinone antitumor, BE-54238B.

The Journal of antibiotics 20040401

Central administration of cocaine- and amphetamine-regulated transcript increases phosphorylation of cAMP response element binding protein in corticotropin-releasing hormone-producing neurons but not in prothyrotropin-releasing hormone-producing neurons in the hypothalamic paraventricular nucleus.

Brain research 20040305

Unexplained metabolic acidosis in critically ill patients: the role of pyroglutamic acid.

Intensive care medicine 20040301

Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery.

Biological & pharmaceutical bulletin 20040301

Human sperm responses to calcitonin, angiotensin II and fertilization-promoting peptide in prepared semen samples from normal donors and infertility patients.

Human reproduction (Oxford, England) 20040301

N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity.

The Journal of endocrinology 20040301

Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation-implications for immunological studies.

Molecular immunology 20040201

Toward the synthesis of pyroglutamate lauroyl ester: biocatalysis versus chemical catalysis.

Biotechnology letters 20040201

Purification of a specific inhibitor of pyroglutamyl aminopeptidase II from the marine annelide Hermodice carunculata. in vivo effects in rodent brain.

The international journal of biochemistry & cell biology 20040101

Regulation of intermediary metabolism and water balance of insects by neuropeptides.

Annual review of entomology 20040101

Pyroglutamyl aminopeptidase I, as a drug metabolizing enzyme, recognizes xenobiotic substrates containing L-2-oxothiazolidine-4-carboxylic acid.

Biological & pharmaceutical bulletin 20040101

Stimulatory effect of PG-KII, an NK3 tachykinin receptor agonist, on isolated pancreatic acini: species-related differences.

Peptides 20040101

Catalytic hydrogenation of glutamic acid.

Applied biochemistry and biotechnology 20040101

Evidence that lamprey GnRH-III does not release FSH selectively in cattle.

Reproduction (Cambridge, England) 20040101

A newborn infant with generalized glutathione synthetase deficiency.

The Turkish journal of pediatrics 20040101

The colon mitosis inhibitor pyroglutamyl-histidyl-glycine inhibits growth of non-tumorigenic colonic epithelial cells.

Anticancer research 20040101

Immune modulator pidotimod decreases the in vitro expression of CD30 in peripheral blood mononuclear cells of atopic asthmatic and normal children.

The Journal of asthma : official journal of the Association for the Care of Asthma 20040101

Pyroglutamyl-histidyl-glycine, the endogenous colon mitosis inhibitor, regulates cyclic AMP level in non-tumorigenic colonic epithelial cells.

Anticancer research 20040101

[Antioxidants-induced rearrangements of actin cytoskeleton in 3T3 and 3T3-SV40 fibroblasts].

Tsitologiia 20040101

3,3',5'-triiodo-L-thyronine reduces efficiency of mRNA knockdown by antisense oligodeoxynucleotides: a study with pyroglutamyl aminopeptidase II in adenohypophysis.

Oligonucleotides 20040101

Pressure/temperature combined treatments of precursors yield hormone-like peptides with pyroglutamate at the N terminus.

Journal of agricultural and food chemistry 20031231

Magnesium supplementation does not delay disease onset or increase survival in a mouse model of familial ALS.

Journal of the neurological sciences 20031215

First messenger regulation of capacitation via G protein-coupled mechanisms: a tale of serendipity and discovery.

Molecular human reproduction 20031201

Thyrotropin-releasing hormone in the dorsal vagal complex stimulates hepatic blood flow in rats.

Hepatology (Baltimore, Md.) 20031201

Sickle cell disease: from membrane pathophysiology to novel therapies for prevention of erythrocyte dehydration.

Journal of pediatric hematology/oncology 20031201

Characterization of a circulating N-extended form of the thyrotropin-releasing hormone-like peptide pGlu-Glu-Pro amide in human plasma.

The Journal of clinical endocrinology and metabolism 20031201

Substrate specificity of glutaminyl cyclases from plants and animals.

Biological chemistry 20031201

Effect of chirality on the structural behaviour of hydrogen-bonded n-alkylammonium pyroglutamates in the crystalline and smectic state.

Chemistry (Weinheim an der Bergstrasse, Germany) 20031107

Glucose acts in the CNS to regulate gastric motility during hypoglycemia.

American journal of physiology. Regulatory, integrative and comparative physiology 20031101

Hydrolysis of synthetic substrate, L-pyroglutamyl p-nitroanilide is catalyzed solely by pyroglutamyl aminopeptidase I in rat liver cytosol.

Biological & pharmaceutical bulletin 20031101

Chemoselective nucleophilic attack on N-acyl derivatives of (S)-ethyl 4,4-dimethyl pyroglutamate (DMPG).

Organic letters 20031016

Involvement of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic cytoprotection.

European journal of pharmacology 20031008

Adipokinetic hormone inhibits the formation of energy stores and egg production in the cricket Gryllus bimaculatus.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20031001

Intracellular mediators of granulysin-induced cell death.

Journal of immunology (Baltimore, Md. : 1950) 20030901

Peristalsis regulation by tachykinin NK1 receptors in the rabbit isolated distal colon.

American journal of physiology. Gastrointestinal and liver physiology 20030801

Fibrosis and glycogen stores depletion induced by prolonged biliary obstruction in the rat are ameliorated by metadoxine.

Liver international : official journal of the International Association for the Study of the Liver 20030801

Pyrrolidinones derived from (S)-pyroglutamic acid: penmacric acid and analogues.

Organic & biomolecular chemistry 20030707

Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats.

Journal of hepatology 20030701

Effect of pyroglutamylasparagine amide on plastic characteristics of synaptic transmission in the hippocampus.

Bulletin of experimental biology and medicine 20030701

L-2-oxothiazolidine-4-carboxylate supplementation in murine gamma-GT deficiency.

Free radical biology & medicine 20030601

Mode of action of neuropeptides from the adipokinetic hormone family.

General and comparative endocrinology 20030601

Relationship between gluconeogenesis and glutathione redox state in rabbit kidney-cortex tubules.

Metabolism: clinical and experimental 20030601

Comparison of structure-activity relations of corazonin using two different bioassay systems.

Peptides 20030601

Intravenous urocortin II decreases blood pressure through CRF(2) receptor in rats.

Regulatory peptides 20030515

Synthesis of cis-4-trifluoromethyl- and cis-4-difluoromethyl-l-pyroglutamic acids.

The Journal of organic chemistry 20030502

[Reproductive toxicity of metadoxine in rats].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20030501

[Oleyl pyroglutamate for use as transdermal enhancer and its enhancing mechanism].

Yao xue xue bao = Acta pharmaceutica Sinica 20030501

Inhibitory effect of L-pyroglutamate on extremophiles: correlation with growth temperature and pH.

FEMS microbiology letters 20030425

Central administration of thyrotropin releasing hormone (TRH) and related peptides inhibits feeding behavior in the Siberian hamster.

Neuroreport 20030415

Intravenous glucose infusion decreases intracisternal thyrotropin-releasing hormone induced vagal stimulation of gastric acid secretion in anesthetized rats.

Neuroscience letters 20030403

Oxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (Pringle maneuver) under hypovolemic conditions.

World journal of surgery 20030401

[Advances in modulation of mammalian sperm function by fertilization promoting peptide].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20030401

Biologic activity of the tachykinins on lamb and sheep gallbladder.

Peptides 20030401

Determination of the post-translational modifications of salivary acidic proline-rich proteins.

European journal of morphology 20030401

Prodrugs to enhance central nervous system effects of the TRH-like peptide pGlu-Glu-Pro-NH2.

Bioorganic & medicinal chemistry letters 20030324

Synthesis and reactions of a novel 3,4-didehydropyroglutamate derivative.

Chemical communications (Cambridge, England) 20030321

Development and conformational analysis of a pseudoproline-containing turn mimic.

The Journal of organic chemistry 20030307

The up-regulation of cyclooxygenase-2 expression in human buccal mucosal fibroblasts by arecoline: a possible role in the pathogenesis of oral submucous fibrosis.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20030301

In vitro metabolism of an insect neuropeptide by homogenates of the nematode Caenorhabditis elegans.

Journal of helminthology 20030301

Reinvestigation of the proposed folding and self-association of the Neuropeptide Head Activator.

Protein science : a publication of the Protein Society 20030301

Ameliorative effect of NC-1900, a new AVP4-9 analog, through vasopressin V1A receptor on scopolamine-induced impairments of spatial memory in the eight-arm radial maze.

Neuropharmacology 20030301

Lafutidine increases hepatic blood flow via potentiating the action of central thyrotropin-releasing hormone in rats.

Journal of gastroenterology and hepatology 20030201

Induction of c-fos expression by nicotine in human periodontal ligament fibroblasts is related to cellular thiol levels.

Journal of periodontal research 20030201

Intrathecal histamine induces spinally mediated behavioral responses through tachykinin NK1 receptors.

Pharmacology, biochemistry, and behavior 20030101

Central administration of neuropeptide Y reduces alpha-melanocyte-stimulating hormone-induced cyclic adenosine 5'-monophosphate response element binding protein (CREB) phosphorylation in pro-thyrotropin-releasing hormone neurons and increases CREB phosphorylation in corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus.

Endocrinology 20030101

Deblocking of N-terminally modified proteins.

Methods in molecular biology (Clifton, N.J.) 20030101

Isolation and identification of indigestible pyroglutamyl peptides in an enzymatic hydrolysate of wheat gluten prepared on an industrial scale.

Journal of agricultural and food chemistry 20030101

Effects of fertilization promoting peptide, adenosine, and pentoxifylline on thawed human sperm.

Archives of andrology 20030101

Metabolism of the calcium and bioavailability of the salts of most frequent use.

Bollettino chimico farmaceutico 20030101

[Neuroprotective properties of pyroglutamic acid in combination with pyrrolidone].

Eksperimental'naia i klinicheskaia farmakologiia 20030101

[Effect of agents changing the intracellular level of reactive oxygen species on the cell cycle phase distribution in 3T3 and 3T3SV40 cell lines].

Tsitologiia 20030101

The colon mitosis-inhibitor pyroglutamyl-histidyl-glycine alters expression of immediate-early cancer-related genes in HT-29 cells.

Anticancer research 20030101

[Neuroprotective and cerebrovascular effects of GABA mimetics].

Eksperimental'naia i klinicheskaia farmakologiia 20030101

Glucose-induced changes in the phenotype of human peritoneal mesothelial cells: effect of L-2-oxothiazolidine carboxylic acid.

American journal of nephrology 20030101

Metadoxine in the treatment of acute and chronic alcoholism: a review.

International journal of immunopathology and pharmacology 20030101

[Therapy with cytokines and thymic factors in a complicated case of common variable immunodeficiency].

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20030101

A new approach to drug therapy in non-alcoholic steatohepatitis (NASH).

The Journal of international medical research 20030101

[The correlation of tolerance to cerebral ischemia and body temperature with glutathione concentration].

Biomeditsinskaia khimiia 20030101

Cocaine regulates TRH-related peptides in rat brain.

Neurochemistry international 20021201

The role of Ins(1,4,5)P(3) in signal transduction of the metabolic neuropeptide Mem-CC in the cetoniid beetle, Pachnoda sinuata.

Insect biochemistry and molecular biology 20021201

Synthesis and preliminary evaluation of trans-3,4-conformationally-restricted glutamate and pyroglutamate analogues as novel EAAT2 inhibitors.

Bioorganic & medicinal chemistry letters 20021104

Leptin regulates bone formation via the sympathetic nervous system.

Cell 20021101

Sensitivity of larval and adult crickets (Gryllus bimaculatus) to adipokinetic hormone.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20021101

Neuropharmacodynamic evaluation of the centrally active thyrotropin-releasing hormone analogue [Leu2]TRH and its chemical brain-targeting system.

Brain research 20021018

Lamprey GnRH-III acts on its putative receptor via nitric oxide to release follicle-stimulating hormone specifically.

Experimental biology and medicine (Maywood, N.J.) 20021001

Activation of raphe pallidus neurons increases insulin through medullary thyrotropin-releasing hormone (TRH)-vagal pathways.

Pancreas 20021001

Production of pyroglutamic acid by thermophilic lactic acid bacteria in hard-cooked mini-cheeses.

Journal of dairy science 20021001

In vivo monitoring of hepatic glutathione in anesthetized rats by 13C NMR.

Magnetic resonance in medicine 20020901

Thyrotropin-releasing hormone regulates the diurnal variation of pyroglutamyl aminopeptidase II activity in the male rat adenohypophysis.

European journal of endocrinology 20020901

Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival.

Journal of neurochemistry 20020901

Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases.

Anti-cancer drugs 20020901

Clinical evaluation and changes of the respiratory epithelium function after administration of Pidotimod in Greek children with recurrent respiratory tract infections.

Minerva pediatrica 20020801

Transmitting the signal of excess nitrogen in Saccharomyces cerevisiae from the Tor proteins to the GATA factors: connecting the dots.

FEMS microbiology reviews 20020801

Effects of dietary cholesterol on pyroglutamyl aminopeptidase activity in mouse frontal cortex, pituitary, and adrenal glands.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020801

Mechanisms of cytotoxicity of nicotine in human periodontal ligament fibroblast cultures in vitro.

Journal of periodontal research 20020801

Effect of a fertilization-promoting peptide on the fertilizing ability and glycosidase activity in vitro of frozen-thawed spermatozoa in the pig.

Animal reproduction science 20020715

Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons.

Neuroscience letters 20020712

Determination of the absolute configuration of 2-hydroxyglutaric acid and 5-oxoproline in urine samples by high-resolution NMR spectroscopy in the presence of chiral lanthanide complexes.

Journal of pharmaceutical and biomedical analysis 20020615

Pharmacologically distinct binding sites in rat brain for [3H]thyrotropin-releasing hormone (TRH) and [3H][3-methyl-histidine(2)]TRH.

Biochemical pharmacology 20020615

Stereoselective total syntheses of the racemic form and the natural enantiomer of the marine alkaloid lepadiformine via a novel N-acyliminium ion/allylsilane spirocyclization strategy.

The Journal of organic chemistry 20020614

Spinal nociceptin inhibits septide but not N-methyl-D-aspartate-induced nociceptive behavior in rats.

European journal of pharmacology 20020607

Pseudopeptide foldamers: the homo-oligomers of pyroglutamic acid.

Chemistry (Weinheim an der Bergstrasse, Germany) 20020603

A possible molecular ancestor for mollusk APGWamide, insect adipokinetic hormone, and crustacean red pigment concentrating hormone.

Journal of molecular evolution 20020601

Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues.

European journal of biochemistry 20020601

Synthesis and biological evaluation of a novel pyroglutamyl-modified TRH analogue.

Farmaco (Societa chimica italiana : 1989) 20020601

Allatostatins of the tiger prawn, Penaeus monodon (Crustacea: Penaeidea).

Peptides 20020601

Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes.

Science (New York, N.Y.) 20020510

Role of TRH receptors as possible mediators of analeptic actions of TRH-like peptides.

Brain research 20020510

Beetles' choice--proline for energy output: control by AKHs.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20020501

Selective tachykinin NK3-receptor agonists stimulate in vitro exocrine pancreatic secretion in the guinea pig.

Peptides 20020501

New insights in Adipokinetic Hormone (AKH) precursor processing in Locusta migratoria obtained by capillary liquid chromatography-tandem mass spectrometry.

Peptides 20020401

Dietary fatty acid composition affects aminopeptidase activities in the testes of mice.

International journal of andrology 20020401

Inhibition of contact hypersensitivity reaction to picryl chloride: effect of small molecular weight peptidomimetic compounds possessing inhibitory activity against metalloproteinases.

International immunopharmacology 20020401

Five- and six-membered ring opening of pyroglutamic diketopiperazine.

The Journal of organic chemistry 20020322

Facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after acute and chronic suppression of dopaminergic transmission in the matrix of the rat striatum.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20020301

Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study.

Alcoholism, clinical and experimental research 20020301

Thyrotropin-releasing hormone-induced down-regulation of pyroglutamyl aminopeptidase II activity involves L-type calcium channels and cam kinase activities in cultures of adenohypophyseal cells.

Journal of neuroendocrinology 20020301

Aminopeptidases in Caenorhabditis elegans and Panagrellus redivivus: detection using peptide and non-peptide substrates.

Journal of helminthology 20020301

Antidiabetic effect of a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, through CD38 dimerization and internalization.

The Journal of biological chemistry 20020215

Conformationally restricted TRH analogues: constraining the pyroglutamate region.

Bioorganic & medicinal chemistry 20020201

Plasma L-5-oxoproline kinetics and whole blood glutathione synthesis rates in severely burned adult humans.

American journal of physiology. Endocrinology and metabolism 20020201

L-2-Oxothiazolidine-4-carboxylate reverses the tumour growth-promoting effect of interleukin-2 and improves the anti-tumour efficacy of biochemotherapy in mice bearing B16 melanoma liver metastases.

Melanoma research 20020201

Purification and characterization of the thyrotropin-releasing hormone (TRH)-degrading serum enzyme and its identification as a product of liver origin.

European journal of biochemistry 20020201

In vivo reversal of glutathione deficiency and susceptibility to in vivo dexamethasone-induced apoptosis by N-acetylcysteine and L-2-oxothiazolidine-4-carboxylic acid, but not ascorbic acid, in thymocytes from gamma-glutamyltranspeptidase-deficient knockout mice.

Archives of biochemistry and biophysics 20020115

Permissive role of neurokinin NK(3) receptors in NK(1) receptor-mediated activation of the locus coeruleus revealed by SR 142801.

Synapse (New York, N.Y.) 20020101

Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide.

Molecular human reproduction 20020101

Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice.

Arteriosclerosis, thrombosis, and vascular biology 20020101

Comparison of the positive and negative ion electrospray mass spectra of some small peptides containing pyroglutamate.

Rapid communications in mass spectrometry : RCM 20020101

Rapid determination of underivatized pyroglutamic acid, glutamic acid, glutamine and other relevant amino acids in fermentation media by LC-MS-MS.

The Analyst 20020101

Efficacy of metadoxine in the management of acute alcohol intoxication.

The Journal of international medical research 20020101

[Polar constituents of the ascidia Botryllus schlosseri].

Bioorganicheskaia khimiia 20020101

Selective hypersensitivity to pidolate.

Allergy 20020101

Early oncogene mRNA expression in HT-29 cells treated with the endogenous colon mitosis inhibitor pyroglutamyl-histidyl-glycine.

Anticancer research 20020101

[Sterility of males determined by functional features of the mouse spermatozoa bearing t-complex].

Ontogenez 20020101

[Pidotimod in recurring respiratory infection in children with allergic rhinitis, asthma, or both conditions].

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20020101

[Effect of a drug composition containing pyroglutamic acid and pyrrolidone on the cerebral circulation].

Eksperimental'naia i klinicheskaia farmakologiia 20020101

L-2-oxothiazolidine-4-carboxylate: an agent that modulates lipopolysaccharide-induced peritonitis in rats.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20020101

Synthesis of ( 2S, 4S)-4-phenylamino-5-oxoproline derivatives.

Amino acids 20020101

Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status.

Redox report : communications in free radical research 20020101

Use of sodium borohydride to detect acyl-phosphate linkages in enzyme reactions.

Methods in enzymology 20020101

[Glutathione in therapy].

Postepy higieny i medycyny doswiadczalnej 20020101

Methacrylate derivatives incorporating pyroglutamic acid.

Biomacromolecules 20020101

[Organic acid disorders: cerebral organic acidemia].

Ryoikibetsu shokogun shirizu 20020101

Electrophilic fluorination of pyroglutamic acid derivatives: application of substrate-dependent reactivity and diastereoselectivity to the synthesis of optically active 4-fluoroglutamic acids.

The Journal of organic chemistry 20011228

Hormonal stimulation of proline synthesis in the fat body of the fruit beetle, Pachnoda sinuata, is calcium dependent.

Insect biochemistry and molecular biology 20011201

In vitro neuroprotection against glutamate-induced toxicity by pGlu-Glu-Pro-NH(2) (EEP).

Peptides 20011201

(L)-2-oxothiazolidine-4-carboxylate in the treatment of primary hyperoxaluria type 1.

BJU international 20011201

L-pyroglutamic acid inhibits energy production and lipid synthesis in cerebral cortex of young rats in vitro.

Neurochemical research 20011201

Efferent projections of ProTRH neurons in the ventrolateral periaqueductal gray.

Brain research 20011123

Metadoxine prevents damage produced by ethanol and acetaldehyde in hepatocyte and hepatic stellate cells in culture.

Pharmacological research 20011101

The neuropeptide head activator induces activation and translocation of the growth-factor-regulated Ca(2+)-permeable channel GRC.

Journal of cell science 20011001

Synthesis of lipids in the fat body of Gryllus bimaculatus: age-dependency and regulation by adipokinetic hormone.

Archives of insect biochemistry and physiology 20010801

Modulators with convergent cellular actions elicit distinct circuit outputs.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20010601

Priming effects of substance P on calcium changes evoked by interleukin-8 in human neutrophils.

Journal of leukocyte biology 20010601

Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus.

Journal of the American College of Nutrition 20010601

Massive 5-oxoprolinuria with normal 5-oxoprolinase and glutathione synthetase activities.

Journal of inherited metabolic disease 20010601

Red pigment-concentrating hormone induces a calcium-mediated retraction of distal retinal pigments in the crayfish.

Journal of comparative physiology. A, Sensory, neural, and behavioral physiology 20010601

Inhibition of Escherichia coli CTP synthase by glutamate gamma-semialdehyde and the role of the allosteric effector GTP in glutamine hydrolysis.

The Biochemical journal 20010515

Intracisternal TRH analog induces Fos expression in gastric myenteric neurons and glia in conscious rats.

American journal of physiology. Gastrointestinal and liver physiology 20010501

Removal of N-terminal blocking groups from proteins.

Current protocols in protein science 20010501

Effect of high population density environment on skin barrier function in mice.

Journal of dermatological science 20010401

Rapid down regulation of pyroglutamyl peptidase II activity by arachidonic acid in primary cultures of adenohypophyseal cells.

Life sciences 20010316

Potent cytolytic response by a CD8+ CTL clone to multiple peptides from the same protein in association with an allogeneic class I MHC molecule.

Journal of immunology (Baltimore, Md. : 1950) 20010301

Calcitonin, angiotensin II and FPP significantly modulate mouse sperm function.

Molecular human reproduction 20010301

In vivo confocal Raman microspectroscopy of the skin: noninvasive determination of molecular concentration profiles.

The Journal of investigative dermatology 20010301

Monoamine release by neurons of a primitive nervous system: an amperometric study.

Journal of neurochemistry 20010301

Conformational study of insect adipokinetic hormones using NMR constrained molecular dynamics.

Journal of computer-aided molecular design 20010301

Regulatory responses to an oral D-glutamate load: formation of D-pyrrolidone carboxylic acid in humans.

American journal of physiology. Endocrinology and metabolism 20010201

Angiotensin II is involved in nitric oxide synthase and cyclo-oxygenase inhibition-induced leukocyte-endothelial cell interactions in vivo.

British journal of pharmacology 20010201

Amino-terminal modification and tyrosine phosphorylation of [corrected] carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain.

Neurobiology of disease 20010201

Bone marrow stem cell protection from chemotherapy by low--molecular-weight compounds.

Experimental hematology 20010201

Hereditary non-spherocytic haemolytic anaemia due to red blood cell glutathione synthetase deficiency in four unrelated patients from Spain: clinical and molecular studies.

British journal of haematology 20010201

Model organisms: new insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster.

American journal of physiology. Cell physiology 20010201

A simultaneous assay method for L-glutamate and L-pyroglutamate contents in soy sauce using a 5-oxoprolinase (without ATP hydrolyzing activity).

Bioscience, biotechnology, and biochemistry 20010201

Intracellular Mg2+ diffusion within isolated rat skeletal muscle fibers.

Biophysical chemistry 20010131

The role of calcium in the activation of glycogen phosphorylase in the fat body of the fruit beetle, Pachnoda sinuata, by hypertrehalosaemic hormone.

Biochimica et biophysica acta 20010115

Imide and lactam derivatives of N-benzylpyroglutamyl-L-phenylalanine as VCAM/VLA-4 antagonists.

Bioorganic & medicinal chemistry letters 20010108

Vagal-enteric interface: vagal activation-induced expression of c-Fos and p-CREB in neurons of the upper gastrointestinal tract and pancreas.

The Anatomical record 20010101

Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010101

Effects of the calcium release inhibitor dantrolene and the Ca2+-ATPase inhibitor thapsigargin on spinal nociception in rats.

Pharmacology 20010101

Fertilization promoting peptide--a possible regulator of sperm function in vivo.

Vitamins and hormones 20010101

Therapeutic strategies for prevention of sickle cell dehydration.

Blood cells, molecules & diseases 20010101

Effect of the hemoregulatory peptide (pEEDCK)2 (pyroGlu-Glu-Asp-Cys-Lys)2 and MIP-1alpha is reduced in bone marrow cultures from patients with chronic myeloid leukemia (CML).

Stem cells (Dayton, Ohio) 20010101

[Metadoxyl in combined treatment of alcohol damage to the liver].

Klinicheskaia meditsina 20010101

Survivability of biomolecules during extraterrestrial delivery: new results on pyrolysis of amino acids and poly-amino acids.

Advances in space research : the official journal of the Committee on Space Research (COSPAR) 20010101

Limited heat-shock protein 72 induction in Caco-2 cells by L-glutamine.

Digestion 20010101

Effect of tumour size on the in vivo growth inhibition of human colon carcinoma cells (HT-29) by colon mitosis inhibitor.

In vivo (Athens, Greece) 20010101

Control of gonadotropin secretion by follicle-stimulating hormone-releasing factor, luteinizing hormone-releasing hormone, and leptin.

Archives of medical research 20010101

A novel cis-peptide bond motif inducing beta-turn type VI. The synthesis of enkephalin analogues modified with 4-aminopyroglutamic acid.

Acta biochimica Polonica 20010101

A third active AKH is present in the pyrgomorphid grasshoppers Phymateus morbillosus and Dictyophorus spumans.

Insect biochemistry and molecular biology 20001101

Synthesis and characterization of water-soluble silver(I) complexes with L-histidine (H2his) and (S)-(-)-2-pyrrolidone-5-carboxylic acid (H2pyrrld) showing a wide spectrum of effective antibacterial and antifungal activities. Crystal structures of chiral helical polymers [Ag(Hhis)]n and ([Ag(Hpyrrld)]2)n in the solid state.

Inorganic chemistry 20000724

A new member of the AKH/RPCH family that stimulates locomotory activity in the firebug, Pyrrhocoris apterus (Heteroptera).

Insect biochemistry and molecular biology 20000601

Effects of L-2-oxothiazolidine-4-carboxylate on the cytotoxic activity and toxicity of cyclophosphamide in mice bearing B16F10 melanoma liver metastases.

Melanoma research 20000401

Synthesis and in vitro anti-HIV activity in human monocyte-derived macrophages of 2-oxothiazolidine-4(R)-carboxylic acid derivatives.

Journal of medicinal chemistry 19991118

The hemoregulatory peptide pEEDCK may inhibit stem cell proliferation via hydropathic binding to antisense sequence motifs in interleukin-11 and other growth factors.

Molecular pharmacology 19991001

Tissue-specific regulation of glutathione homeostasis and the activator protein-1 (AP-1) response in the rat conceptus.

Biochemical pharmacology 19990515

The growth-inhibiting epidermal pentapeptide, pyroGlu-glu-asp-ser-GlyOH, inhibits growth and alters gene expression in non-transformed NC3H10 and transformed TC3H10 fibroblasts.

Oncology reports 19990101

Activated granulocytes oxidize the endogenous stem cell inhibitory peptide pGlu-Glu-Asp-Cys-Lys (pEEDCK) to the stimulatory dimer: a redox-mediated mechanism for demand-induced hematopoietic regulation.

Experimental hematology 19980801

Analogs of Manduca adipokinetic hormone tested in a bioassay and in a receptor-binding assay.

Peptides 19980101

Isolation and characterization of Melanoplus sanguinipes adipokinetic hormone: a new member of the AKH/RPCH family.

Biochemical and biophysical research communications 19971029

Protective effects of L-2-oxothiazolidine-4-carboxylate treatment on cyclophosphamide-induced cystitis in rats.

The Journal of urology 19970501

L-2-oxothiazolidine-4-carboxylic acid inhibits human immunodeficiency virus type 1 replication in mononuclear phagocytes and lymphocytes.

Clinical and diagnostic laboratory immunology 19970501

No. 302, a newly synthesized [pGlu4,Cyt6]AVP(4-9) analogue, prevents the disruption of avoidance behavior.

Behavioural brain research 19970201

Reduction in the duration of myelotoxicity associated with radioimmunotherapy with infusions of the hemoregulatory peptide, HP5b in mice.

International journal of cancer 19970127

Distinct sequences of AKH/RPCH family members in beetle (Scarabaeus-species) corpus cardiacum contain three aromatic amino acid residues.

Biochemical and biophysical research communications 19970103

Hyperprolinaemia caused by novel members of the adipokinetic hormone/red pigment-concentrating hormone family of peptides isolated from corpora cardiaca of onitine beetles.

The Biochemical journal 19970101

Insect neuropeptide leucopyrokinin analogues--synthesis and antinociceptive effect in rats.

Polish journal of pharmacology 19970101

Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis.

FEBS letters 19961216

Hydrolytic cleavage of pyroglutamyl-peptide bond. III. A highly selective cleavage in 70% methanesulfonic acid.

Chemical & pharmaceutical bulletin 19961101

Probing the V1a vasopressin receptor binding site with pyroglutamate-substituted linear antagonists.

Neuropeptides 19960201

Supplementation with L-2-oxothiazolidine-4-carboxylic acid, a cysteine precursor, does not protect against lipid peroxidation in puromycin aminonucleoside-induced nephropathy.

Experimental nephrology 19960101

Amino acid sequence of CAP2b, an insect cardioacceleratory peptide from the tobacco hawkmoth Manduca sexta.

FEBS letters 19950911

Primary structure of a novel neuropeptide isolated from the corpora cardiaca of periodical cicadas having adipokinetic and hypertrehalosemic activities.

Insect biochemistry and molecular biology 19950901

[A granulopoiesis inhibitor. Synthesis and biological activity].

Bioorganicheskaia khimiia 19950601

Inhibitory peptides in hematopoiesis.

Experimental hematology 19950601

L-2-oxothiazolidine-4-carboxylic acid (procysteine) inhibits expression of the human immunodeficiency virus and expression of the interleukin-2 receptor alpha chain.

Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 19950201

Isolation and primary structures of neuropeptides of the AKH/RPCH family from various termite species.

Peptides 19950101

Isolation of two AKH-related peptides from cicadas.

Archives of insect biochemistry and physiology 19950101

Zinc and the mitosis-inhibitory epidermal pentapeptide (EPP) form a stimulatory chelated dimer.

Archives of dermatological research 19950101

Biologically active pyroglutamyl N-terminal oligopeptides: parts of larger molecules?

Physiological chemistry and physics and medical NMR 19950101

Regional distribution and immunocytological localization of red pigment concentrating hormone in the crayfish eyestalk.

General and comparative endocrinology 19940901

A novel adipokinetic octapeptide found in the damselflies Pseudagrion inconspicuum and Ischnura senegalensis.

The Biochemical journal 19940901

Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in in vitro studies of HIV replication.

AIDS research and human retroviruses 19940801

Metamorphosin A: a novel peptide controlling development of the lower metazoan Hydractinia echinata (Coelenterata, Hydrozoa).

Developmental biology 19940601

Role of oxygen free radicals in cocaine-induced vascular disruption in mice.

Teratology 19940301

A novel peptide in the AKH/RPCH family isolated from the corpora cardiaca of the Emperor dragonfly, Anax imperator.

Peptides 19940101

Beta-receptor blockade by propranolol modifies the effect of the inhibitory, endogenous epidermal pentapeptide on epidermal cell flux at the G2-M transition but not at the G1-S transition.

Epithelial cell biology 19940101

Moderate enhancement of the promotion phase of skin tumorigenesis in hairless mice by topical pretreatment with a mitosis-inhibiting epidermal pentapeptide.

Carcinogenesis 19931201

The neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) increases levels of inositol 1,4,5-trisphosphate in the tentacle retractor muscle of Helix aspersa.

Experimental physiology 19931101

Isolation, identification and synthesis of locustapyrokinin II from Locusta migratoria, another member of the FXPRL-amide peptide family.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 19930901

Pre-CFU-S quiescence and stem cell exhaustion after cytostatic drug treatment: protective effects of the inhibitory peptide pGlu-Glu-Asp-Cys-Lys (pEEDCK).

Blood 19930401

Audiogenic seizures in magnesium-deficient mice: effects of magnesium pyrrolidone-2-carboxylate, magnesium acetyltaurinate, magnesium chloride and vitamin B-6.

Magnesium research 19930301

Isolation of Antho-RFamide related peptides from the eyestalks of blue crab.

Comparative biochemistry and physiology. B, Comparative biochemistry 19930201

Primary structure of a cardioactive neuropeptide from the tobacco hawkmoth, Manduca sexta.

FEBS letters 19921123

Hydra head activator peptide has trophic activity for eukaryotic neurons.

Brain research. Developmental brain research 19920724

Isolation of the neuropeptide less than Glu-Trp-Leu-Lys-Gly-Arg-Phe-NH2 (Pol-RFamide II) from the hydromedusa Polyorchis penicillatus.

Biochemical and biophysical research communications 19920316

Isolation and primary structure of a novel pheromonotropic neuropeptide structurally related to leucopyrokinin from the armyworm larvae, Pseudaletia separata.

Biochemical and biophysical research communications 19920131

Modulation of KB and A431 cell adhesion by epidermal growth inhibitory pentapeptide.

Virchows Archiv. B, Cell pathology including molecular pathology 19920101

Effect of combination treatment with analogs of luteinizing hormone-releasing hormone (LH-RH) or somatostatin and 5-fluorouracil on pancreatic cancer in hamsters.

International journal of cancer 19910909

A unique charged tyrosine-containing member of the adipokinetic hormone/red-pigment-concentrating hormone peptide family isolated and sequenced from two beetle species.

The Biochemical journal 19910501

Primary structure of the precursor for the sea anemone neuropeptide Antho-RFamide (less than Glu-Gly-Arg-Phe-NH2).

Proceedings of the National Academy of Sciences of the United States of America 19910315

Protection from arabinofuranosylcytosine and n-mustard-induced myelotoxicity using hemoregulatory peptide pGlu-Glu-Asp-Cys-Lys monomer and dimer.

Blood 19910315

The adipokinetic neuropeptide of Mantodea. Sequence elucidation and evolutionary relationships.

Biological chemistry Hoppe-Seyler 19910301

The peptide pyroGlu-Gln-Gly-Ser-Asn, isolated from mouse liver, inhibits growth of rat hepatoma cells in vitro.

Carcinogenesis 19910201

Isolation and structure elucidation of a novel adipokinetic hormone (Lom-AKH-III) from the glandular lobes of the corpus cardiacum of the migratory locust, Locusta migratoria.

European journal of biochemistry 19910130

Inhibitory epidermal pentapeptide modulates proliferation and differentiation of transformed mouse epidermal cells in vitro.

Virchows Archiv. B, Cell pathology including molecular pathology 19910101

The epidermal pentapeptide pyroGlu-Glu-Asp-Ser-GlyOH inhibits murine hair growth in vivo and in vitro.

Dermatologica 19910101

Degradation of adipokinetic hormone family peptides by a circulating endopeptidase in the insect Manduca sexta.

Peptides 19910101

An efficient chemical-enzymatic synthesis of LHRH N-terminal pentapeptide.

Biomedica biochimica acta 19910101

Inhibition of hematopoietic stem cell proliferation by hemoregulatory peptide pyroGlu-Glu-Asp-Cys-Lys (pEEDCK) provides protection against short-term neutropenia and long-term damage.

Annals of the New York Academy of Sciences 19910101

The use of haemoregulatory peptides (pEEDCK monomer and dimer) for reduction of cytostatic drug induced haemopoietic damage.

Cancer treatment reviews 19900901

The fruitfly Drosophila melanogaster contains a novel charged adipokinetic-hormone-family peptide.

The Biochemical journal 19900715

Isolation and structure of a novel charged member of the red-pigment-concentrating hormone-adipokinetic hormone family of peptides isolated from the corpora cardiaca of the blowfly Phormia terraenovae (Diptera).

The Biochemical journal 19900715

The putative ancestral peptide of the adipokinetic/red-pigment-concentrating hormone family isolated and sequenced from a dragonfly.

Biological chemistry Hoppe-Seyler 19900601

TRH-extended peptides in the olfactory lobe are formed by incomplete cleavage at pairs of arginine residues in the TRH prohormone.

FEBS letters 19900521

Norvaline2-TRH: binding to TRH receptors in rat brain homogenates.

European journal of pharmacology 19900503

Prevention of hematotoxic side effects of cytostatic drugs in mice by a synthetic hemoregulatory peptide.

Cancer research 19900115

Mouse epidermal cell renewal after topical treatment with different concentrations of the epidermal peptide pyroGlu-Glu-Asp-Ser-GlyOH.

Virchows Archiv. B, Cell pathology including molecular pathology 19900101

UVB-induced epidermal hyperproliferation is modified by a single, topical treatment with a mitosis inhibitory epidermal pentapeptide.

The Journal of investigative dermatology 19900101

The primary structure of the hypertrehalosemic neuropeptide from tenebrionid beetles: a novel member of the AKH/RPCH family.

Peptides 19900101

Pentapeptide inhibitor of epidermal mitosis: production and responsiveness in cultures of normal, transformed and neoplastic human keratinocytes.

Carcinogenesis 19891201

Suppressive biological activity of a synthetic pentapeptide on highly enriched human and murine marrow hematopoietic progenitors: synergism with recombinant human tumor necrosis factor-alpha and interferon-gamma.

Experimental hematology 19891001

Biosynthesis of adipokinetic hormones (AKHs): further characterization of precursors and identification of novel products of processing.

The Journal of neuroscience : the official journal of the Society for Neuroscience 19890301

Enhancement of methylnitrosourea-induced skin tumorigenesis and carcinogenesis in hairless mice by pretreatment with a mitosis-inhibiting epidermal pentapeptide.

Carcinogenesis 19890201

Controversies in TRH biosynthesis and strategies towards the identification of a TRH precursor.

Annals of the New York Academy of Sciences 19890101

The metabolic neuropeptides of the corpus cardiacum from the potato beetle and the American cockroach are identical.

Peptides 19890101

Isolation of less than Glu-Ser-Leu-Arg-Trp-NH2, a novel neuropeptide from sea anemones.

Brain research 19880301

[A synthetic peptide from Helix aspersa raises arterial pressure in rats].

Zhurnal evoliutsionnoi biokhimii i fiziologii 19880101

Primary sequence analysis by fast atom bombardment mass spectrometry of a peptide with adipokinetic activity from the corpora cardiaca of the cricket Gryllus bimaculatus.

Biochemical and biophysical research communications 19871231

Effect of pyroglutamic acid stereoisomers on ECS and scopolamine-induced memory disruption and brain acetylcholine levels in the rat.

Pharmacological research communications 19871201

Inhibitory activity of a synthetic pentapeptide on leukaemic myelopoiesis both in vitro and in vivo in rats.

European journal of haematology 19871101

The actions of FMRFamide-like peptides on visceral and somatic muscles of the snail Helix aspersa.

The Journal of experimental biology 19870901

Sequential processing reactions in the formation of hormone amides.

European journal of biochemistry 19870817

Isolation and structure of an epidermal mitosis inhibiting pentapeptide.

Biochemical and biophysical research communications 19870814

Specific processing of the thyrotropin-releasing prohormone in rat brain and spinal cord.

European journal of biochemistry 19870615

Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides.

Proceedings of the National Academy of Sciences of the United States of America 19870601

Active fragments and analogs of the insect neuropeptide leucopyrokinin: structure-function studies.

Biochemical and biophysical research communications 19860630

Processing of the thyrotropin releasing hormone (TRH) precursor in Xenopus skin and bovine hypothalamus: evidence for the existence of extended forms of TRH.

Regulatory peptides 19860501

Primary structure of gonadotropin-releasing hormone from lamprey brain.

The Journal of biological chemistry 19860415

Isolation and primary structure of a peptide from the corpora cardiaca of Heliothis zea with adipokinetic activity.

Biochemical and biophysical research communications 19860313

Immunohistochemical localization in the rat brain of the precursor for thyrotropin-releasing hormone.

Science (New York, N.Y.) 19850913

[Synthesis of cyclic and non-cyclic tachykinin partial sequences. 2. Synthesis of the homocyclic substance P(6-11) hexapeptide].

Die Pharmazie 19850801

Rohdei-litorin: a new peptide from the skin of Phyllomedusa rohdei.

FEBS letters 19850311

Arterial blood pressure response in conscious rabbits to administration of C-terminal fragment of substance P into the cerebral ventricles, intravenously and intragastrically.

Arzneimittel-Forschung 19850101

The isolation and characterization of an insulin-releasing tetrapeptide from urines of patients with lipoatrophic diabetes.

Biochemical and biophysical research communications 19840718

C-terminal amidation of neuropeptides. Gly-Lys-Arg extension an efficient precursor of C-terminal amide.

FEBS letters 19840213

Cleavage of Trimeresurus flavoviridis phospholipase A2 with cyanogen bromide: sequence of the short peptide fragment and formation of a noncovalently bonded complex from the fragments.

Journal of biochemistry 19810801

An approach to the elucidation of metabolic breakdown products of the luteinizing hormone-releasing hormone.

Journal of medicinal chemistry 19810601

Preparation of 3H-[3-M3-His2]TRH as an improved ligand for TRH receptors.

Neuroendocrinology 19810501