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149-46-2

149-46-2 | 1,3-Benzenedisulfonic acid, 4,5-dihydroxy-

CAS No: 149-46-2 Catalog No: AG001LC7 MDL No:

Product Description

Catalog Number:
AG001LC7
Chemical Name:
1,3-Benzenedisulfonic acid, 4,5-dihydroxy-
CAS Number:
149-46-2
Molecular Formula:
C6H6O8S2
Molecular Weight:
270.2370
IUPAC Name:
4,5-dihydroxybenzene-1,3-disulfonic acid
InChI:
InChI=1S/C6H6O8S2/c7-4-1-3(15(9,10)11)2-5(6(4)8)16(12,13)14/h1-2,7-8H,(H,9,10,11)(H,12,13,14)
InChI Key:
XXAXVMUWHZHZMJ-UHFFFAOYSA-N
SMILES:
Oc1cc(cc(c1O)S(=O)(=O)O)S(=O)(=O)O
UNII:
306J0THJ9U

Properties

Complexity:
440  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
269.95g/mol
Formal Charge:
0
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
270.226g/mol
Monoisotopic Mass:
269.95g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
166A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.7  

Literature

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Determination of aluminium using high performance chelation ion chromatography. Journal of separation science 20080701
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Reactive oxygen species contribute to Ca2+ signals produced by osmotic stress in mouse skeletal muscle fibres. The Journal of physiology 20080101
Study on the effects of nitrilotriproprionic acid and 4,5-dihydroxy-1,3-benzene disulphonate on the fractionation of beryllium in human serum using graphite furnace atomic absorption spectrometry. Chemistry Central journal 20080101
Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II. BMC chemical biology 20080101
Antioxidant systems and oxidative stress in the testes. Oxidative medicine and cellular longevity 20080101
Oxygen-derived free radicals mediate endothelium-dependent contractions in femoral arteries of rats with streptozotocin-induced diabetes. British journal of pharmacology 20071201
Reactive oxygen species are messengers in maintenance of human and guinea pig gallbladder tonic contraction. American journal of physiology. Gastrointestinal and liver physiology 20071201
Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. Journal of cell science 20071201
Calmagite dye oxidation using in situ generated hydrogen peroxide catalysed by manganese(II) ions. Dalton transactions (Cambridge, England : 2003) 20071128
Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate. Nature chemical biology 20071101
Adrenergic response of splanchnic arteries from cirrhotic patients: role of nitric oxide, prostanoids, and reactive oxygen species. Experimental biology and medicine (Maywood, N.J.) 20071101
Direct voltammetric specific recognition of dopamine using AlIII-DA complexes at the hanging mercury drop electrode. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20071101
Antioxidants restore aortic ring relaxation in pancreatectomized rats. Life sciences 20071027
Endothelium-dependent relaxation of isolated splanchnic arteries from cirrhotic patients: Role of reactive oxygen species. Hepatology research : the official journal of the Japan Society of Hepatology 20071001
Reactive oxygen species in the paraventricular nucleus mediate the cardiac sympathetic afferent reflex in chronic heart failure rats. European journal of heart failure 20071001
Influence of organic ligands on the reduction of polyhalogenated alkanes by iron(II). Environmental science & technology 20071001
NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts. Cardiovascular research 20070901
IGF-I plus E2 induces proliferation via activation of ROS-dependent ERKs and JNKs in human breast carcinoma cells. Journal of cellular physiology 20070901
The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow. American journal of physiology. Heart and circulatory physiology 20070901
Increased spontaneous tone in renal arteries of spontaneously hypertensive rats. American journal of physiology. Heart and circulatory physiology 20070901
Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20070901
Enhanced hydroxyl radical production by dihydroxybenzene-driven Fenton reactions: implications for wood biodegradation. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20070901
Photocatalytic mechanisms of indoleamine destruction by the quinalphos metabolite 2-hydroxyquinoxaline: a study on melatonin and its precursors serotonin and N-acetylserotonin. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20070801
The catalytic mode of cysteine proteinases of papain (C1) family. Bioresource technology 20070701
Effects of elevated physiological temperatures on sarcoplasmic reticulum function in mechanically skinned muscle fibers of the rat. American journal of physiology. Cell physiology 20070701
Effect of polyethylene glycols on the function and structure of thiol proteases. Journal of biochemistry 20070701
Superoxide signaling mediates N-acetyl-L-cysteine-induced G1 arrest: regulatory role of cyclin D1 and manganese superoxide dismutase. Cancer research 20070701
A superoxide anion generator, pyrogallol induces apoptosis in As4.1 cells through the depletion of intracellular GSH content. Mutation research 20070601
Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide. British journal of pharmacology 20070601
Enhanced superoxide production in renal outer medulla of Dahl salt-sensitive rats reduces nitric oxide tubular-vascular cross-talk. Hypertension (Dallas, Tex. : 1979) 20070601
Chelation therapy and vanadium: effect on reproductive organs in rats. Indian journal of experimental biology 20070601
Real-time measurement of nitric oxide in single mature mouse skeletal muscle fibres during contractions. The Journal of physiology 20070515
Calcium and reactive oxygen species increase in endothelial cells in response to releasers of endothelium-derived contracting factor. British journal of pharmacology 20070501
Antioxidants tiron and N-acetyl-L-cysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species-independent NF-kappaB pathway. Free radical biology & medicine 20070501
Disruption of skeletal myocytes initiates superoxide release: contribution of NADPH oxidase. Shock (Augusta, Ga.) 20070501
Effect of tiron and its combination with nutritional supplements against vanadium intoxication in female albino rats. The Journal of toxicological sciences 20070501
Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. The Journal of biological chemistry 20070420
Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertension. American journal of physiology. Heart and circulatory physiology 20070401
The changes of intracellular H2O2 are an important factor maintaining mitochondria membrane potential of antimycin A-treated As4.1 juxtaglomerular cells. Biochemical pharmacology 20070315
Role of organically complexed iron(II) species in the reductive transformation of RDX in anoxic environments. Environmental science & technology 20070215
Generation of superoxide anion by equine spermatozoa as detected by dihydroethidium. Theriogenology 20070201
Induction of oxidative stress response by the mycotoxin patulin in mammalian cells. Toxicological sciences : an official journal of the Society of Toxicology 20070201
An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Experimental hematology 20070201
Homocysteine-induced changes in vascular reactivity of guinea-pig pulmonary arteries: role of the oxidative stress and poly (ADP-ribose) polymerase activation. Pulmonary pharmacology & therapeutics 20070101
Interstitial matrix proteins determine hyaluronan reflection and fluid retention in rabbit joints: effect of protease. The Journal of physiology 20070101
The CX3C chemokine fractalkine induces vascular dysfunction by generation of superoxide anions. Arteriosclerosis, thrombosis, and vascular biology 20070101
Highly sensitive determination of transient generation of biophotons during hypersensitive response to cucumber mosaic virus in cowpea. Journal of experimental botany 20070101
Role of combined administration of Tiron and glutathione against aluminum-induced oxidative stress in rat brain. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20070101
Matrix replenishment by intervertebral disc cells after chemonucleolysis in vitro with chondroitinase ABC and chymopapain. The spine journal : official journal of the North American Spine Society 20070101
Insulin withdrawal induces apoptosis via a free radical-mediated mechanism. Canadian journal of physiology and pharmacology 20070101
Determination of alkali-labile phosphoprotein phosphorus from fish plasma using the Tb(3+)-tiron complex as a fluorescence probe. Journal of environmental sciences (China) 20070101
Platelet-derived exosomes from septic shock patients induce myocardial dysfunction. Critical care (London, England) 20070101
[Formation of superoxide radicals in isolated cardiac mitochondria: effect of adriamycin]. Biofizika 20070101
Activation of potassium channels by tempol in arterial smooth muscle cells from normotensive and deoxycorticosterone acetate-salt hypertensive rats. Hypertension (Dallas, Tex. : 1979) 20061201
Goat cerebrovascular reactivity to ADP after ischemia-reperfusion. Role of nitric oxide, prostanoids and reactive oxygen species. Brain research 20061120
Hyperhomocysteinemia increases arterial permeability and stiffness in mice. American journal of physiology. Regulatory, integrative and comparative physiology 20061101
High-fat diet-induced reduction in nitric oxide-dependent arteriolar dilation in rats: role of xanthine oxidase-derived superoxide anion. American journal of physiology. Heart and circulatory physiology 20061101
Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain research 20061003
Progression of coronary and mesenteric vascular dysfunction in Zucker obese and Zucker diabetic fatty rats. American journal of physiology. Heart and circulatory physiology 20061001
Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity. Cardiovascular research 20061001
MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice. Arteriosclerosis, thrombosis, and vascular biology 20061001
Aminonaphthoquinone induces oxidative stress in Staphylococcus aureus. Biochemistry and cell biology = Biochimie et biologie cellulaire 20061001
Modulation by homocysteine of the iberiotoxin-sensitive, Ca2+ -activated K+ channels of porcine coronary artery smooth muscle cells. European journal of pharmacology 20060928
Adjacent bronchus attenuates pulmonary arterial contractility. American journal of physiology. Lung cellular and molecular physiology 20060901
Production of superoxide and dissipation of mitochondrial transmembrane potential by vitamin K2 trigger apoptosis in human ovarian cancer TYK-nu cells. Apoptosis : an international journal on programmed cell death 20060901
Serotype-specific invasiveness and colonization prevalence in Streptococcus pneumoniae correlate with the lag phase during in vitro growth. Microbes and infection 20060901
Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity -- role for iron-dependent oxidative stress. Free radical biology & medicine 20060815
The complement component C5a induces the expression of plasminogen activator inhibitor-1 in human macrophages via NF-kappaB activation. Journal of thrombosis and haemostasis : JTH 20060801
Participation of superoxide in neutrophil activation and cytokine production. Biochimica et biophysica acta 20060801
Adsorption of heavy metals on vermiculite: influence of pH and organic ligands. Journal of colloid and interface science 20060715
Effects of hsp90 binding inhibitors on sGC-mediated vascular relaxation. American journal of physiology. Heart and circulatory physiology 20060701
Synthetic peroxisome proliferator-activated receptor-gamma agonists restore impaired vasorelaxation via ATP-sensitive K+ channels by high glucose. The Journal of pharmacology and experimental therapeutics 20060701
Hofmeister effects in protein unfolding kinetics: estimation of changes in surface area upon formation of the transition state. Biochimica et biophysica acta 20060701
Redox activation of aldose reductase in the ischemic heart. The Journal of biological chemistry 20060602
Effects of Tiron, 4,5-dihydroxy-1,3-benzene disulfonic acid, on human promyelotic HL-60 leukemia cell differentiation and death. Toxicology 20060601
Ischemia/reperfusion injury in the monolayers of human intestinal epithelial cell line caco-2 and its recovery by antioxidants. Drug metabolism and pharmacokinetics 20060601
Vitamin K1 (phylloquinone) induces vascular endothelial dysfunction: role of oxidative stress. Toxicology and applied pharmacology 20060515
Abiotic reduction of nitroaromatic compounds by aqueous iron(ll)-catechol complexes. Environmental science & technology 20060501
[Chemical modification of chymopapain with monomethoxypolyethylene glycol and its effect on enzymic activity and antigenicity]. Wei sheng yan jiu = Journal of hygiene research 20060501
PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells. The Journal of biological chemistry 20060428
NAD(P)H oxidase-stimulating activity of serum from type 2 diabetic patients with retinopathy mediates enhanced endothelial expression of E-selectin. Life sciences 20060425
Aluminum-induced maternal and developmental toxicity and oxidative stress in rat brain: response to combined administration of Tiron and glutathione. Reproductive toxicology (Elmsford, N.Y.) 20060401
Noninvasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats. The Journal of pharmacology and experimental therapeutics 20060401
Tempol in the dorsomedial hypothalamus attenuates the hypertensive response to stress in rabbits. American journal of hypertension 20060401
Structural characterization of the papaya cysteine proteinases at low pH. Biochemical and biophysical research communications 20060310
Hypoxia-induced reactive oxygen species downregulate ETB receptor-mediated contraction of rat pulmonary arteries. American journal of physiology. Lung cellular and molecular physiology 20060301
Characteristics and actions of NAD(P)H oxidase on the sarcoplasmic reticulum of coronary artery smooth muscle. American journal of physiology. Heart and circulatory physiology 20060301
Stereospecific and redox-sensitive increase in monocyte adhesion to endothelial cells by homocysteine. Arteriosclerosis, thrombosis, and vascular biology 20060301
Upregulation of osteopontin gene expression in diabetic rat proximal tubular cells revealed by microarray profiling. Kidney international 20060301
Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expression. American journal of physiology. Renal physiology 20060201
Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1. American journal of respiratory cell and molecular biology 20060201
Macrophage migration inhibitory factor increases neuronal delayed rectifier K+ current. Journal of neurophysiology 20060201
Dihydroartemisinin enhances radiosensitivity of human glioma cells in vitro. Journal of cancer research and clinical oncology 20060201
In vivo fragmentation of the large subunit of ribulose-1,5-bisphosphate carboxylase by reactive oxygen species in an intact leaf of cucumber under chilling-light conditions. Plant & cell physiology 20060201
Purification and characterization of extracellular cysteine protease inhibitor, ECPI-2, from Chlorella sp. Journal of bioscience and bioengineering 20060201
Antioxidants prevent oxidative DNA damage and cellular transformation elicited by the over-expression of c-MYC. Mutation research 20060129
Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis. European journal of pharmacology 20060120
Chemical blockage of the proteasome inhibitory function of bortezomib: impact on tumor cell death. The Journal of biological chemistry 20060113
Angiotensin II-induced negative inotropy in rat ventricular myocytes: role of reactive oxygen species and p38 MAPK. American journal of physiology. Heart and circulatory physiology 20060101
Hypoxic reperfusion of the ischemic heart and oxygen radical generation. American journal of physiology. Heart and circulatory physiology 20060101
Vascular dysfunction produced by hyperhomocysteinemia is more severe in the presence of low folate. American journal of physiology. Heart and circulatory physiology 20060101
Prolonged oxidative stress inverts the cardiac force-frequency relation: role of altered calcium handling and myofilament calcium responsiveness. Journal of molecular and cellular cardiology 20060101
Abnormal development and increased 3-nitrotyrosine in copper-deficient mouse embryos. Free radical biology & medicine 20060101
Platelet regulation by NO/cGMP signaling and NAD(P)H oxidase-generated ROS. Blood cells, molecules & diseases 20060101
Proinflammatory cytokine-induced NF-kappaB activation in human mesangial cells is mediated through intracellular calcium but not ROS: effects of silymarin. Nephron. Experimental nephrology 20060101
[Production of oxygen free radicals by cardiac mitochondria: effect of hypoxia-reoxygenation]. Biofizika 20060101
NAD(P)H oxidase activity of Nox4 in chondrocytes is both inducible and involved in collagenase expression. Antioxidants & redox signaling 20060101
Photon emissions from rice cells elicited by N-acetylchitooligosaccharide are generated through phospholipid signaling in close association with the production of reactive oxygen species. Plant physiology and biochemistry : PPB 20060101
O2- activates leaf injury, ethylene and salicylic acid synthesis, and the expression of O3-induced genes in O3-exposed tobacco. Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101
Abscisic acid-induced apoplastic H2O2 accumulation up-regulates the activities of chloroplastic and cytosolic antioxidant enzymes in maize leaves. Planta 20051201
Effects of acute ethanol administration on LPS-induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in rat alveolar macrophages. Alcoholism, clinical and experimental research 20051201
[The role of superoxide anions in regulation of coronary vessel tone and myocardial contractile function in changed redox-state of the myocardium]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20051201
Activation of NAD(P)H oxidase by outward movements of H+ ions in renal medullary thick ascending limb of Henle. American journal of physiology. Renal physiology 20051101
Ultraviolet-B-induced oxidative stress and responses of the ascorbate-glutathione cycle in a marine macroalga Ulva fasciata. Journal of experimental botany 20051101
Activation of vascular BK channel by tempol in DOCA-salt hypertensive rats. Hypertension (Dallas, Tex. : 1979) 20051101
Up-regulation of glomerular COX-2 by angiotensin II: role of reactive oxygen species. Kidney international 20051101
Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway. Blood 20051015
Reactive oxygen species in paraventricular nucleus modulates cardiac sympathetic afferent reflex in rats. Brain research 20051005
Oxidative stress promotes endothelial cell apoptosis and loss of microvessels in the spontaneously hypertensive rats. Arteriosclerosis, thrombosis, and vascular biology 20051001
Reduced hyperpolarization in endothelial cells of rabbit aortic valve following chronic nitroglycerine administration. British journal of pharmacology 20051001
Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation. Hypertension (Dallas, Tex. : 1979) 20051001
NO restores HIF-1alpha hydroxylation during hypoxia: role of reactive oxygen species. Free radical biology & medicine 20051001
A physiogenomic approach to study the regulation of blood pressure. Physiological genomics 20050921
Superoxide targets calcineurin signaling in vascular endothelium. Biochemical and biophysical research communications 20050909
Intracellular generation of reactive oxygen species by contracting skeletal muscle cells. Free radical biology & medicine 20050901
Superoxide determines nitric oxide uptake rate by vascular smooth muscle cells. FEBS letters 20050815
gp91phox-containing NAD(P)H oxidase mediates attenuation of nitric oxide-dependent control of myocardial oxygen consumption by ANG II. American journal of physiology. Heart and circulatory physiology 20050801
Tempol reduces reperfusion-induced arrhythmias in anaesthetized rats. Pharmacological research 20050801
New aspect of the synergistic antibacterial action of ampicillin and gentamicin. International journal of antimicrobial agents 20050801
Effects of electron transport inhibitors and uncouplers on the oxidation of ferrous iron and compounds interacting with ferric iron in Acidithiobacillus ferrooxidans. Canadian journal of microbiology 20050801
Endothelin-1, via ETA receptor and independently of transforming growth factor-beta, increases the connective tissue growth factor in vascular smooth muscle cells. Circulation research 20050722
Kinetics of iron release from ferric binding protein (FbpA): mechanistic implications in bacterial periplasm-to-cytosol Fe3+ transport. Biochemistry 20050719
Accelerated impairment of spermatogenic cells in SOD1-knockout mice under heat stress. Free radical research 20050701
Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling. Chemical research in toxicology 20050601
Radiation-induced apoptosis in peritoneal resident macrophages of C3H mice: selective involvement of superoxide anion, but not other reactive oxygen species. International journal of radiation biology 20050601
HSP25 inhibits radiation-induced apoptosis through reduction of PKCdelta-mediated ROS production. Oncogene 20050526
Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SOD-deficient mice. American journal of physiology. Heart and circulatory physiology 20050501
Superoxide scavengers augment contractile but not energetic responses to hypoxia in rat diaphragm. Journal of applied physiology (Bethesda, Md. : 1985) 20050501
Mg-dechelation activity in radish cotyledons with artificial and native substrates, Mg-chlorophyllin a and chlorophyllide a. Plant physiology and biochemistry : PPB 20050501
Endothelial NO Synthase (eNOS) phosphorylation regulates coronary diameter during ischemia-reperfusion in association with oxidative stress. Free radical research 20050501
Hydrogen peroxide and endothelium-dependent hyperpolarization in the guinea-pig carotid artery. European journal of pharmacology 20050425
Prostaglandin D(2) and J(2) induce apoptosis in human leukemia cells via activation of the caspase 3 cascade and production of reactive oxygen species. Biochimica et biophysica acta 20050415
Reactive oxygen species reduce myofibrillar Ca2+ sensitivity in fatiguing mouse skeletal muscle at 37 degrees C. The Journal of physiology 20050401
A new functionalized resin and its application in preconcentration system with multivariate optimization for nickel determination in food samples. Talanta 20050331
Copper sensitivity of cueO mutants of Escherichia coli K-12 and the biochemical suppression of this phenotype. Biochemical and biophysical research communications 20050325
Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade. Biochemical pharmacology 20050315
Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells. Biochimica et biophysica acta 20050311
A defect of neuronal nitric oxide synthase increases xanthine oxidase-derived superoxide anion and attenuates the control of myocardial oxygen consumption by nitric oxide derived from endothelial nitric oxide synthase. Circulation research 20050218
Determination of traces molybdenum by catalytic adsorptive stripping voltammetry. Talanta 20050215
Exogenous NO suppresses flow-induced endothelium-derived NO production because of depletion of tetrahydrobiopterin. American journal of physiology. Heart and circulatory physiology 20050201
Endostatin uncouples NO and Ca2+ response to bradykinin through enhanced O2*- production in the intact coronary endothelium. American journal of physiology. Heart and circulatory physiology 20050201
Effects of co-administration of antioxidants and arsenicals on the rat urinary bladder epithelium. Toxicological sciences : an official journal of the Society of Toxicology 20050201
Vascular responses to IGF-I and insulin are impaired in aortae of hypertensive rats. Journal of hypertension 20050201
Hyperglycemia activates JAK2 signaling pathway in human failing myocytes via angiotensin II-mediated oxidative stress. Diabetes 20050201
Effects of scavengers for active oxygen species on cell death by cryptogein. Phytochemistry 20050201
Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis. Oncogene 20050120
Vascular smooth muscle cell NAD(P)H oxidase activity during the development of hypertension: Effect of angiotensin II and role of insulinlike growth factor-1 receptor transactivation. American journal of hypertension 20050101
Production of intracellular superoxide mediates dithiothreitol-dependent inhibition of apoptotic cell death. Antioxidants & redox signaling 20050101
C-reactive protein induces NF-kappaB activation through intracellular calcium and ROS in human mesangial cells. Nephron. Experimental nephrology 20050101
High sodium intake increases vascular superoxide formation and promotes atherosclerosis in apolipoprotein E-deficient mice. Blood pressure 20050101
Stability of aqueous TiO2 suspensions: influence of ethanol. Journal of colloid and interface science 20041215
Role of ERK activation in cisplatin-induced apoptosis in A172 human glioma cells. Neurotoxicology 20041201
Inhibitory effect of high concentration of glucose on relaxations to activation of ATP-sensitive K+ channels in human omental artery. Arteriosclerosis, thrombosis, and vascular biology 20041201
Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells. The Journal of endocrinology 20041201
Characterization of the influence of nitric oxide donors on intestinal absorption of macromolecules. International journal of pharmaceutics 20041122
Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circulation research 20041112
Hypercholesterolemia impairs transduction of vasodilator signals derived from ischemic myocardium: myocardium-microvessel cross-talk. Arteriosclerosis, thrombosis, and vascular biology 20041101
Nox1 regulates apoptosis and potentially stimulates branching morphogenesis in sinusoidal endothelial cells. Experimental cell research 20041101
High glucose mediates pro-oxidant and antioxidant enzyme activities in coronary endothelial cells. Diabetes, obesity & metabolism 20041101
Important role of superoxide dismutase in EDHF-mediated responses of human mesenteric arteries. Journal of cardiovascular pharmacology 20041101
Factors affecting the potentiometric response of all-solid-state solvent polymeric membrane calcium-selective electrode for low-level measurements. Analytical chemistry 20041101
[Study of preparation methods of polyclonal antibody of chymopapain]. Wei sheng yan jiu = Journal of hygiene research 20041101
Endothelium-derived reactive oxygen species and endothelin-1 attenuate NO-dependent pulmonary vasodilation following chronic hypoxia. American journal of physiology. Lung cellular and molecular physiology 20041001
Structural basis of protein kinetic stability: resistance to sodium dodecyl sulfate suggests a central role for rigidity and a bias toward beta-sheet structure. Biochemistry 20040907
Degradation of rat cardiac troponin I during ischemia independent of reperfusion. American journal of physiology. Heart and circulatory physiology 20040901
Flavone inhibition of tumor growth via apoptosis in vitro and in vivo. International journal of oncology 20040901
Vasomotor responses in MnSOD-deficient mice. American journal of physiology. Heart and circulatory physiology 20040901
Activation of phospholipase D induced by hydrogen peroxide in suspension-cultured rice cells. Plant & cell physiology 20040901
Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. The Journal of biological chemistry 20040813
Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke 20040801
Activation of the oxidative burst by yeast elicitor in Catharanthus roseus cells occurs independently of the activation of genes involved in alkaloid biosynthesis. Plant molecular biology 20040801
Permeation liquid membrane as a tool for monitoring bioavailable Pb in natural waters. The Science of the total environment 20040726
Tempol attenuates excitatory actions of angiotensin II in the rostral ventrolateral medulla during emotional stress. Hypertension (Dallas, Tex. : 1979) 20040701
Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats. American journal of physiology. Heart and circulatory physiology 20040601
Angiotensin II and endothelin-1 regulate MAP kinases through different redox-dependent mechanisms in human vascular smooth muscle cells. Journal of hypertension 20040601
Comparative effectiveness of CaNa3DTPA and tiron along with alpha-tocopherol against beryllium-induced biochemical alterations in rats. Indian journal of experimental biology 20040601
Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats. Circulation 20040518
Insulin generates free radicals by an NAD(P)H, phosphatidylinositol 3'-kinase-dependent mechanism in human skin fibroblasts ex vivo. Diabetes 20040501
gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension. Circulation 20040413
NAD(P)H oxidase associated superoxide production in human placenta from normotensive and pre-eclamptic women. Placenta 20040401
p22phox-derived superoxide mediates enhanced proliferative capacity of diabetic vascular smooth muscle cells. Diabetes research and clinical practice 20040401
Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and mitogen-activated protein kinase activation. Circulation 20040316
ERK1/2 and JNKs, but not p38 kinase, are involved in reactive oxygen species-mediated induction of osteopontin gene expression by angiotensin II and interleukin-1beta in adult rat cardiac fibroblasts. Journal of cellular physiology 20040301
Abeta-induced vascular oxidative stress and attenuation of functional hyperemia in mouse somatosensory cortex. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20040301
Renal oxidative stress in medullary thick ascending limbs produced by elevated NaCl and glucose. Hypertension (Dallas, Tex. : 1979) 20040201
Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts. Journal of cellular biochemistry 20040201
Role of oxidative stress and nitric oxide in regulation of spontaneous tone in aorta of DOCA-salt hypertensive rats. British journal of pharmacology 20040201
Catecholamine-induced vascular wall growth is dependent on generation of reactive oxygen species. Circulation research 20040109
Changes in NO bioavailability regulate cardiac O2 consumption: control by intramitochondrial SOD2 and intracellular myoglobin. American journal of physiology. Heart and circulatory physiology 20040101
Hydrogen peroxide mediates FK506-induced cytotoxicity in renal cells. Kidney international 20040101
Peroxynitrite decomposition catalyst ameliorates renal damage and protein nitration in cisplatin-induced nephrotoxicity in rats. BMC pharmacology 20040101
Reactive oxygen species mediate arachidonic acid-induced dilation in porcine coronary microvessels. American journal of physiology. Heart and circulatory physiology 20031201
Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species. Cancer research 20031201
Extracellular alkalosis activates ERK mitogen-activated protein kinase of vascular smooth muscle cells through NADPH-mediated formation of reactive oxygen species. FEBS letters 20031120
Coordination solids via assembly of adaptable components: systematic structural variation in alkaline earth organosulfonate networks. Chemistry (Weinheim an der Bergstrasse, Germany) 20031107
Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide. Experimental cell research 20031101
Flow-injection spectrophotometry of vanadium by catalysis of the bromate oxidation of N,N'-bis(2-hydroxyl-3-sulfopropyl)-tolidine. Talanta 20031017
Rhein induces apoptosis in HL-60 cells via reactive oxygen species-independent mitochondrial death pathway. Archives of biochemistry and biophysics 20031015
Abnormal growth of polyamine-deficient Escherichia coli mutant is partially caused by oxidative stress-induced damage. Archives of biochemistry and biophysics 20031015
Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: in vivo and ex vivo evidence from ecSOD-deficient mice. Circulation research 20031003
Expression of senescence-enhanced genes in response to oxidative stress. Journal of experimental botany 20031001
Solid phase extraction-spectrophotometric determination of dissolved aluminum in soil extracts and ground waters. Journal of inorganic biochemistry 20030915
Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. The Journal of biological chemistry 20030905
Low-level endotoxin induces potent inflammatory activation of human blood vessels: inhibition by statins. Arteriosclerosis, thrombosis, and vascular biology 20030901
Formation of hydrogen peroxide and nitric oxide in rat skeletal muscle cells during contractions. Free radical biology & medicine 20030901
Differential roles of hydrogen peroxide and hydroxyl radical in cisplatin-induced cell death in renal proximal tubular epithelial cells. The Journal of laboratory and clinical medicine 20030901
Angiotensin II produces superoxide-mediated impairment of endothelial function in cerebral arterioles. Stroke 20030801
Impaired activities of antioxidant enzymes elicit endothelial dysfunction in spontaneous hypertensive rats despite enhanced vascular nitric oxide generation. Cardiovascular research 20030801
Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization. American journal of physiology. Heart and circulatory physiology 20030701
Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertension. American journal of physiology. Heart and circulatory physiology 20030701
Electron spin resonance detection of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in porcine coronary microvessels. Arteriosclerosis, thrombosis, and vascular biology 20030701
Confirmation of superoxide generation via xanthine oxidase in streptozotocin-induced diabetic mice. Free radical research 20030701
Enhancing effect of melatonin on chemiluminescence accompanying decomposition of hydrogen peroxide in the presence of copper. Free radical biology & medicine 20030615
Capillary electrophoresis as a nanoreactor of separation capability: on-capillary reaction catalyzed by transition metal ions. Electrophoresis 20030601
Selenite activates caspase-independent necrotic cell death in Jurkat T cells and J774.2 macrophages by affecting mitochondrial oxidant generation. Antioxidants & redox signaling 20030601
Effects of iron and oxygen species scavengers on Listeria spp. chemiluminescence. Biochemical and biophysical research communications 20030516
NAD(P)H oxidase participates in the signaling events in high glucose-induced proliferation of vascular smooth muscle cells. Life sciences 20030502
In vivo gene transfer of inducible nitric oxide synthase to carotid arteries from hypercholesterolemic rabbits. Stroke 20030501
Cyclosporin A disrupts bradykinin signaling through superoxide. Hypertension (Dallas, Tex. : 1979) 20030501
Anesthetic preconditioning improves adenosine triphosphate synthesis and reduces reactive oxygen species formation in mitochondria after ischemia by a redox dependent mechanism. Anesthesiology 20030501
Involvement of H2O2 in superoxide-dismutase-induced enhancement of endothelium-dependent relaxation in rabbit mesenteric resistance artery. British journal of pharmacology 20030501
Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes. Circulation 20030415
Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity. Free radical biology & medicine 20030401
AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase. Circulation 20030401
[The protection of Tiron to the injury of organ of Corti cultured in vitro caused by exogenous H2O2 in mouse]. Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20030401
The use of intra-articular Na-hyaluronate as a potential chondroprotective device in experimentally induced acute articular cartilage injury and repair in rabbits. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20030301
Anti-oxidant effects of estrogen reduce [Ca2+]i during metabolic inhibition. Journal of molecular and cellular cardiology 20030301
Humic acid mediates iron release from ferritin and promotes lipid peroxidation in vitro: a possible mechanism for humic acid-induced cytotoxicity. Archives of toxicology 20030201
Redox-dependent MAP kinase signaling by Ang II in vascular smooth muscle cells: role of receptor tyrosine kinase transactivation. Canadian journal of physiology and pharmacology 20030201
Comparative study on fluorescence enhancement and quenching of europium and terbium chelate anions in cationic micelles. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030115
Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK. The Journal of biological chemistry 20030103
Oxidation of melatonin by carbonate radicals and chemiluminescence emitted during pyrrole ring cleavage. Journal of pineal research 20030101
Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation. Neuroscience research 20030101
Specific potentiation of endothelium-dependent contractions in SHR by tetrahydrobiopterin. Hypertension (Dallas, Tex. : 1979) 20030101
Spectrophotometric determination of iron(III) and total iron by sequential injection analysis technique. Talanta 20021206
Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide. American journal of physiology. Heart and circulatory physiology 20021201
Water stress-induced abscisic acid accumulation triggers the increased generation of reactive oxygen species and up-regulates the activities of antioxidant enzymes in maize leaves. Journal of experimental botany 20021201
DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species. Chemical research in toxicology 20021201
[The preparation and identification of rabbit's antibody of chymopapain]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20021201
Role of ceramide in TNF-alpha-induced impairment of endothelium-dependent vasorelaxation in coronary arteries. American journal of physiology. Heart and circulatory physiology 20021101
Reversible changes in Ca(2+)-activation properties of rat skeletal muscle exposed to elevated physiological temperatures. The Journal of physiology 20021101
Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin. Circulation research 20021018
Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen. American journal of physiology. Heart and circulatory physiology 20021001
Reactive oxygen species generated during myocardial ischemia enable energetic recovery during reperfusion. American journal of physiology. Heart and circulatory physiology 20021001
Thiolic antioxidants protect from nitric oxide-induced toxicity in fetal midbrain cultures. Neuropharmacology 20021001
Strain-dependent variation in vascular responses to nitric oxide in the isolated murine heart. Journal of molecular and cellular cardiology 20021001
Spectrophotometric assay of superoxide anion formed in Maillard reaction based on highly water-soluble tetrazolium salt. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20021001
Histamine release by hydrochloric acid is mediated via reactive oxygen species generation and phospholipase D in RBL-2H3 mast cells. Archives of pharmacal research 20021001
Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in DOCA-salt rats. American journal of physiology. Heart and circulatory physiology 20020901
Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging in rats. Arteriosclerosis, thrombosis, and vascular biology 20020901
Effect of oral glucosamine on cartilage and meniscus in normal and chymopapain-injected knees of young rabbits. Arthritis and rheumatism 20020901
Melatonin's unique radical scavenging properties - roles of its functional substituents as revealed by a comparison with its structural analogs. Journal of pineal research 20020801
High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells. Endocrinology 20020801
Effect of prolonged incubation with copper on endothelium-dependent relaxation in rat isolated aorta. British journal of pharmacology 20020801
Protective effect of Tiron (4,5-dihydroxybenzene-1,3-disulfonic acid disodium salt) against beryllium-induced maternal and fetal toxicity in rats. Archives of toxicology 20020801
Tiron exerts effects unrelated to its role as a scavenger of superoxide anion: effects on calcium binding and vascular responses. Canadian journal of physiology and pharmacology 20020801
Withdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in mice. Circulation research 20020726
Dissolution of plutonium(IV) hydroxide by desferrioxamine siderophores and simple organic chelators. Inorganic chemistry 20020715
Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: morphological and functional evidence for increased peroxynitrite formation. The American journal of pathology 20020701
The c-Rel transcription factor can both induce and inhibit apoptosis in the same cells via the upregulation of MnSOD. Oncogene 20020627
Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circulation research 20020614
Nitric oxide modulates superoxide release and peroxynitrite formation in human blood vessels. Hypertension (Dallas, Tex. : 1979) 20020601
Liposomal NAD(+) prevents diminished O(2) consumption by immunostimulated Caco-2 cells. American journal of physiology. Lung cellular and molecular physiology 20020501
Oxygen-derived free radicals mediate endothelium-dependent contractions to acetylcholine in aortas from spontaneously hypertensive rats. British journal of pharmacology 20020501
Oxidative stress involves in astrocytic alterations induced by manganese. Experimental neurology 20020501
Solution equilibrium studies on metal complexes of 2,3-dihydroxy-phenylalanine-hydroxamic acid (Dopaha) and models: catecholate versus hydroxamate coordination in iron(III)-, aluminium(III)- and molybdenum(VI)-Dopaha complexes. Journal of inorganic biochemistry 20020428
Genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells exposed to peroxynitrite generated from SIN-1. Chemical research in toxicology 20020401
Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis. The Journal of biological chemistry 20020308
Thiram inhibits angiogenesis and slows the development of experimental tumours in mice. British journal of cancer 20020304
The effect of bone remodeling inhibition by zoledronic acid in an animal model of cartilage matrix damage. Osteoarthritis and cartilage 20020301
Effects of NADH and NADPH on superoxide levels and cerebral vascular tone. American journal of physiology. Heart and circulatory physiology 20020201
Molecular characterization of a superoxide-generating NAD(P)H oxidase in the ventilatory muscles. American journal of respiratory and critical care medicine 20020201
Urea as a passive transport marker for arthritis biomarker studies. Arthritis and rheumatism 20020201
Effects of Fe(III) chemical speciation on dissimilatory Fe(III) reduction by Shewanella putrefaciens. Environmental science & technology 20020201
Native LDL induces proliferation of human vascular smooth muscle cells via redox-mediated activation of ERK 1/2 mitogen-activated protein kinases. Hypertension (Dallas, Tex. : 1979) 20020201
Modulation of inducible nitric oxide synthase by hypoxia in pulmonary artery endothelial cells. American journal of respiratory cell and molecular biology 20020101
Oxygen consumption and electron spin resonance studies of free radical production by alveolar cells exposed to anoxia: inhibiting effects of the antibiotic ceftazidime. Redox report : communications in free radical research 20020101
Bench-to-bedside review: Cytopathic hypoxia. Critical care (London, England) 20020101
[The protective action of ubiquinone at ischemia and reperfusion]. Kardiologiia 20020101
Clarification of the mechanism of structural change induced by reoxygenation following the induction of lipid peroxidation in Caco-2 cell monolayers. Drug metabolism and pharmacokinetics 20020101
Free radicals in hypoxic rat diaphragm contractility: no role for xanthine oxidase. American journal of physiology. Lung cellular and molecular physiology 20011201
Increased inactivation of nitric oxide is involved in impaired coronary flow reserve in heart failure. American journal of physiology. Heart and circulatory physiology 20011201
Involvement of superoxide generation in salicylic acid-induced stomatal closure in Vicia faba. Plant & cell physiology 20011201
Role of reactive oxygen intermediates in Japanese encephalitis virus infection in murine neuroblastoma cells. Neuroscience letters 20011123
Complement-mediated cell death induced by rituximab in B-cell lymphoproliferative disorders is mediated in vitro by a caspase-independent mechanism involving the generation of reactive oxygen species. Blood 20011101
ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts. Circulation research 20011012
Superoxide levels and function of cerebral blood vessels after inhibition of CuZn-SOD. American journal of physiology. Heart and circulatory physiology 20011001
Spectrofluorimetric determination of copper(II) by its static quenching effect on the fluorescence of 4,5-dihydroxy-1,3-benzenedisulfonic acid. Talanta 20010803
Structural studies of uranium and thorium complexes with 4,5-dihydroxy-3,5-benzenesdisulfonate (Tiron) at low and neutral pH by X-ray absorption spectroscopy. Inorganic chemistry 20010604
IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress. Diabetes 20010601
Role of endothelium in shear stress-induced constrictions in rat middle cerebral artery. Stroke 20010601
An optical biosensor employing tiron-immobilised polypyrrole films for estimating monophenolase activity in apple juice. Biosensors & bioelectronics 20010601
Effect of St. John's wort on free radical production. Life sciences 20010601
Palmitate-induced apoptosis can occur through a ceramide-independent pathway. The Journal of biological chemistry 20010504
Increased NAD(P)H oxidase and reactive oxygen species in coronary arteries after balloon injury. Arteriosclerosis, thrombosis, and vascular biology 20010501
Sulfite oxidation by iron-grown cells of Thiobacillus ferrooxidans at pH 3 possibly involves free radicals, iron, and cytochrome oxidase. Canadian journal of microbiology 20010501
Impaired modulation of sympathetic vasoconstriction in contracting skeletal muscle of rats with chronic myocardial infarctions: role of oxidative stress. Circulation research 20010427
Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries. Circulation research 20010427
Ca2+ mediates the effect of inhibition of Na+-K+-ATPase on the basolateral K+ channels in the rat CCD. American journal of physiology. Cell physiology 20010401
Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells. Arteriosclerosis, thrombosis, and vascular biology 20010401
Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. Circulation research 20010119
Antioxidant treatment induces transcription and expression of transforming growth factor beta in cultured renal proximal tubular cells. FEBS letters 20010119
Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure. American journal of physiology. Heart and circulatory physiology 20010101
4-dimethylamino-3',4'-dimethoxychalcone downregulates iNOS expression and exerts anti-inflammatory effects. Free radical biology & medicine 20010101
Involvement of reactive oxygen species in the induction of (S)-N-p-coumaroyloctopamine accumulation by beta-1,3-glucooligosaccharide elicitors in potato tuber tissues. Zeitschrift fur Naturforschung. C, Journal of biosciences 20010101
Insight to structural subsite recognition in plant thiol protease-inhibitor complexes : understanding the basis of differential inhibition and the role of water. BMC structural biology 20010101
Metal-organic complexation in the marine environment. Geochemical transactions 20010101

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