CAS 148849-67-6 | 2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1) | CAS Number 148849-67-6

Title	Journal
Ivabradine: A Unique and Intriguing Medication for Treating Cardiovascular Disease.	Cardiology in review 20150101
An evaluation of the pharmacokinetics and pharmacodynamics of ivabradine for the treatment of heart failure.	Expert opinion on drug metabolism & toxicology 20140201
Inhibition of I(f) in the atrioventricular node as a mechanism for dronedarone's reduction in ventricular rate during atrial fibrillation.	Heart rhythm 20131101
Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect.	Journal of cardiovascular electrophysiology 20130801
Identification of potent Yes1 kinase inhibitors using a library screening approach.	Bioorganic & medicinal chemistry letters 20130801
Ivabradine in systemic sclerosis related pulmonary arterial hypertension.	European journal of internal medicine 20121201
Ivabradine: a ray of hope for inappropriate sinus tachycardia.	Journal of the American College of Cardiology 20121009
Clinical efficacy of ivabradine in patients with inappropriate sinus tachycardia: a prospective, randomized, placebo-controlled, double-blind, crossover evaluation.	Journal of the American College of Cardiology 20121009
Ivabradine for chronic heart failure?	Drug and therapeutics bulletin 20121001
[New pharmacological approaches to ischemic heart disease].	Giornale italiano di cardiologia (2006) 20121001
Ivabradine reduces total hospital burden in heart failure.	Cardiovascular journal of Africa 20121001
Therapeutic effects of ivabradine on hemodynamic parameters and cardiotoxicity induced by doxorubicin treatment in rat.	Human & experimental toxicology 20120901
Beneficial effect of ivabradine in dilated cardiomyopathy from Becker muscular dystrophy.	Herz 20120901
Lasting reduction of heart transplant tachycardia with ivabradine is effective and well tolerated: results of 48-month study.	Clinical research in cardiology : official journal of the German Cardiac Society 20120801
Pharmacokinetic interaction between ivabradine and phenytoin in healthy subjects.	Clinical drug investigation 20120801
Safety and efficacy of oral ivabradine as a heart rate-reducing agent in patients undergoing CT coronary angiography.	The British journal of radiology 20120801
Safe and well-tolerated treatment with ivabradine in systemic sclerosis affected by pulmonary hypertension.	Clinical research in cardiology : official journal of the German Cardiac Society 20120701
Treating stable angina - is there a NICE way towards an international consensus?	International journal of clinical practice 20120701
The 2012 ESC Guidelines on Heart Failure.	European heart journal 20120701
Anti-inflammatory effects of ivabradine in patients with acute coronary syndrome: a pilot study.	International journal of cardiology 20120628
Role of heart rate as a marker and mediator of poor outcome for patients with heart failure.	Current heart failure reports 20120601
Differential effects of ivabradine and ryanodine on pacemaker activity in canine sinus node and purkinje fibers.	Journal of cardiovascular electrophysiology 20120601
Heart rate-lowering efficacy and respiratory safety of ivabradine in patients with obstructive airway disease: a randomized, double-blind, placebo-controlled, crossover study.	American journal of cardiovascular drugs : drugs, devices, and other interventions 20120601
[Ivabradine: heart rate reduction in coronary heart disease and chronic heart failure].	Medizinische Monatsschrift fur Pharmazeuten 20120601
Recent developments in the management of heart failure.	The Practitioner 20120601
Effects on outcomes of heart rate reduction by ivabradine in patients with congestive heart failure: is there an influence of beta-blocker dose?: findings from the SHIFT (Systolic Heart failure treatment with the I(f) inhibitor ivabradine Trial) study.	Journal of the American College of Cardiology 20120529
It is all about heart rate. Or is it?	Journal of the American College of Cardiology 20120529
Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis.	European heart journal 20120501
Ivabradine in combination with beta-blocker improves symptoms and quality of life in patients with stable angina pectoris: results from the ADDITIONS study.	Clinical research in cardiology : official journal of the German Cardiac Society 20120501
Should we SHIFT our thinking about digoxin? Observations on ivabradine and heart rate reduction in heart failure.	European heart journal 20120501
Role of heart rate reduction in the prevention of experimental heart failure: comparison between If-channel blockade and β-receptor blockade.	Hypertension (Dallas, Tex. : 1979) 20120501
Heart rate reduction: an old and novel candidate heart failure therapy.	Hypertension (Dallas, Tex. : 1979) 20120501
The biological effects of ivabradine in cardiovascular disease.	Molecules (Basel, Switzerland) 20120430
Incremental value and safety of oral ivabradine for heart rate reduction in computed tomography coronary angiography.	International journal of cardiology 20120405
β-blockers in stage B: a precursor of heart failure.	Heart failure clinics 20120401
Effect of ivabradine vs atenolol on heart rate and effort tolerance in patients with mild to moderate mitral stenosis and normal sinus rhythm.	Journal of cardiac failure 20120401
[Update coronary artery disease: important progresses in acute and chronic therapy].	MMW Fortschritte der Medizin 20120322
Long-term treatment with ivabradine in post-myocardial infarcted rats counteracts f-channel overexpression.	British journal of pharmacology 20120301
Heart rate reduction induced by the if current inhibitor ivabradine improves diastolic function and attenuates cardiac tissue hypoxia.	Journal of cardiovascular pharmacology 20120301
Effects of ivabradine on the pulmonary vein electrical activity and modulation of pacemaker currents and calcium homeostasis.	Journal of cardiovascular electrophysiology 20120201
The funny current (If): is it a novel antiarrhythmic target to treat atrial fibrillation?	Journal of cardiovascular electrophysiology 20120201
Increased time varying heart rate and cardiovascular risk in hypertension: benefit of selective I((f)) channel inhibitor?	Blood pressure 20120201
Effects of ivabradine on heart rate and left ventricular function in healthy cats and cats with hypertrophic cardiomyopathy.	American journal of veterinary research 20120201
Ivabradine versus metoprolol for heart rate reduction before coronary computed tomography angiography.	The American journal of cardiology 20120115
Dose-dependent protective effect of ivabradine against ischemia-reperfusion-induced renal injury in rats.	Kidney & blood pressure research 20120101
[Efficacy of ivabradine in patients with stable angina and comorbid chronic obstructive pulmonary disease].	Kardiologiia 20120101
[The SHIFT study: a shift in a correct direction].	Kardiologiia 20120101
Effects of treatment with ivabradine and atenolol on reproducibility of echocardiographic indices of left heart size and function in healthy cats.	Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20120101
Acquired haemophilia secondary to ivabradine presenting with acute respiratory distress syndrome.	BMJ case reports 20120101
Concomitant administration of different doses of simvastatin with ivabradine influence on PAI-1 and heart rate in normo- and hypercholesterolaemic rats.	TheScientificWorldJournal 20120101
Heart rate reduction by ivabradine improves aortic compliance in apolipoprotein E-deficient mice.	Journal of vascular research 20120101
Comparison of effects of ivabradine versus carvedilol in murine model with the Coxsackievirus B3-induced viral myocarditis.	PloS one 20120101
[Pharmacological correction of heart rate in myocardial ischemia].	Terapevticheskii arkhiv 20120101
The 'funny' current (I(f)) inhibition by ivabradine at membrane potentials encompassing spontaneous depolarization in pacemaker cells.	Molecules (Basel, Switzerland) 20120101
[Effect of ivabradine on pulmonary hypertension in chronic obstructive pulmonary disease].	Kardiologiia 20120101
[Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and health related quality of life: results from the SHIFT substudies].	Vnitrni lekarstvi 20120101
Ivabradine and nightmares: a previously unreported adverse reaction.	European journal of clinical pharmacology 20111201
Efficacy of ivabradine in combination with Beta-blocker versus uptitration of Beta-blocker in patients with stable angina.	Cardiovascular drugs and therapy 20111201
Limited role for ivabradine in the treatment of chronic heart failure.	Heart (British Cardiac Society) 20111201
Beta-blocker dose up-titration or addition of ivabradine in stable angina: more is not necessarily better : editorial to: 'efficacy of ivabradine in combination with beta-blocker versus uptitration of beta-blocker in patients with stable angina' by E. Amosova et al.	Cardiovascular drugs and therapy 20111201
Pharmacodynamic effects of ivabradine, a negative chronotropic agent, in healthy cats.	Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20111201
Heart rate-associated mechanical stress impairs carotid but not cerebral artery compliance in dyslipidemic atherosclerotic mice.	American journal of physiology. Heart and circulatory physiology 20111101
Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress.	Basic research in cardiology 20111101
Natural history of end-stage LV dysfunction: has it improved from the classic Franciosa and Cohn Graph?	Cardiology clinics 20111101
[Ivabradine (pure heart-rate-lowering agent)].	Nihon rinsho. Japanese journal of clinical medicine 20111101
Electrophysiological effects of ivabradine in dog and human cardiac preparations: potential antiarrhythmic actions.	European journal of pharmacology 20111015
Pharmacokinetics of oral ivabradine in healthy cats.	Journal of veterinary pharmacology and therapeutics 20111001
Reducing elevated heart rate in patients with multiple organ dysfunction syndrome by the I (f) (funny channel current) inhibitor ivabradine : MODI (f)Y trial.	Clinical research in cardiology : official journal of the German Cardiac Society 20111001
Left ventricular remodelling in systolic heart failure using ivabradine. Slower is smaller is better?	European heart journal 20111001
Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy.	European heart journal 20111001
Heart rate reduction with ivabradine and health related quality of life in patients with chronic heart failure: results from the SHIFT study.	European heart journal 20111001
The importance of reducing heart rate in cardiovascular diseases: effects of Ivabradine.	Minerva medica 20111001
Effect of Carvedilol, Ivabradine or their combination on exercise capacity in patients with Heart Failure (the CARVIVA HF trial).	International journal of cardiology 20110901
A pediatric case of cardiomyopathy induced by inappropriate sinus tachycardia: efficacy of ivabradine.	Pediatric cardiology 20110801
Heart rate reduction with ivabradine increases ischaemia-induced ventricular fibrillation threshold: role of myocyte structure and myocardial perfusion.	Resuscitation 20110801
Ivabradine, a novel heart rate slower: is it a sword of double blades in patients with idiopathic dilated cardiomyopathy?	Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20110801
Medical therapy versus myocardial revascularization in chronic coronary syndrome and stable angina.	The American journal of medicine 20110801
Selective and specific I(f) inhibition with ivabradine: new perspectives for the treatment of cardiovascular disease.	Expert review of cardiovascular therapy 20110801
[New agents for the therapy of angina pectoris].	Der Internist 20110701
[Angina pectoris: improving symptoms and prognosis. With ivabradine less angina pectoris and reduced need for nitrates].	MMW Fortschritte der Medizin 20110616
[Reducing heart rate to treat angina pectoris].	Revue medicale suisse 20110608
Heart rate contributes to the vascular effects of chronic mental stress: effects on endothelial function and ischemic brain injury in mice.	Stroke 20110601
Ivabradine added to guidelines-based therapy in systolic heart failure patients.	Internal and emergency medicine 20110601
Heart rate: a forgotten link in coronary artery disease?	Nature reviews. Cardiology 20110426
Pharmacokinetic interaction between ivabradine and carbamazepine in healthy volunteers.	Journal of clinical pharmacy and therapeutics 20110401
[Heart failure].	Deutsche medizinische Wochenschrift (1946) 20110401
[New therapeutic approaches in heart failure].	Deutsche medizinische Wochenschrift (1946) 20110401
The use of ivabradine for inappropriate sinus tachycardia.	Acta cardiologica 20110401
Safety of ivabradine in patients with coronary artery disease and left ventricular systolic dysfunction (from the BEAUTIFUL Holter Substudy).	The American journal of cardiology 20110315
Reversal of tachycardiomyopathy due to left atrial tachycardia by ivabradine.	Journal of cardiovascular electrophysiology 20110301
Single centre experience of ivabradine in postural orthostatic tachycardia syndrome.	Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20110301
Ivabradine improves coronary flow reserve in patients with stable coronary artery disease.	Atherosclerosis 20110301
Ivabradine: an hypothesis generating study--an important link between bench and bedside.	Atherosclerosis 20110301
Ivabradine reduces heart rate while preserving metabolic fluxes and energy status of healthy normoxic working hearts.	American journal of physiology. Heart and circulatory physiology 20110301
Ivabradine in the treatment of orthostatic intolerance.	Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20110301
Innovation in coronary artery disease and heart failure: clinical benefits of pure heart rate reduction with ivabradine.	Annals of the New York Academy of Sciences 20110301
Effect of heart rate reduction by ivabradine on left ventricular remodeling in the echocardiographic substudy of BEAUTIFUL.	International journal of cardiology 20110203
Ivabradine for the treatment of stable angina pectoris in octogenarians.	Clinical research in cardiology : official journal of the German Cardiac Society 20110201
[Postural orthostatic tachycardia syndrome: current concepts in pathophysiology, diagnosis and therapeutic options].	Fortschritte der Neurologie-Psychiatrie 20110201
Ivabradine: recent and potential applications in clinical practice.	Expert opinion on pharmacotherapy 20110201
Heart rate decrease: a new paradigm in the treatment of heart failure. Insights from the SHIFT study.	Archives of cardiovascular diseases 20110201
Reversal of cardiomyopathy with ivabradine.	Internal medicine journal 20110201
Heart rate reduction with ivabradine prevents the global phenotype of left ventricular remodeling.	American journal of physiology. Heart and circulatory physiology 20110101
Heart rate and heart failure. Not a simple relationship.	Circulation journal : official journal of the Japanese Circulation Society 20110101
Rate control with ivabradine: angina pectoris and beyond.	American journal of cardiovascular drugs : drugs, devices, and other interventions 20110101
[Ivabradine].	Perspective infirmiere : revue officielle de l'Ordre des infirmieres et infirmiers du Quebec 20110101
Comparison of the effects of ivabradine and atenolol on heart rate and echocardiographic variables of left heart function in healthy cats.	Journal of veterinary internal medicine 20110101
[The SHIFT study].	Giornale italiano di cardiologia (2006) 20110101
Spironolactone diminishes spontaneous ventricular premature beats by reducing HCN4 protein expression in rats with myocardial infarction.	Molecular medicine reports 20110101
[From results of BEAUTIFUL trial to results of SHIFT trial: BEAUTIFUL possibility to make a SHIFT in current guidelines].	Kardiologiia 20110101
Heart failure: ivabradine is no better than optimised beta-blocker therapy.	Prescrire international 20110101
Selective pharmacological inhibition of the pacemaker channel isoforms (HCN1-4) as new possible therapeutical targets.	Current medicinal chemistry 20110101
Cardioprotection by ivabradine through heart rate reduction and beyond.	Journal of cardiovascular pharmacology and therapeutics 20110101
New data support ivabradine use in chronic heart failure.	Cardiovascular journal of Africa 20110101
[Alternative therapy with ivabradine in patients with functional class III chronic heart failure].	Kardiologiia 20110101
[Efficacy of ivabradin in combined treatment of patients with postinfarction systolic chronic cardiac failure].	Terapevticheskii arkhiv 20110101
Ivabradine and outcomes in chronic heart failure.	Lancet (London, England) 20101218
Ivabradine and outcomes in chronic heart failure.	Lancet (London, England) 20101218
Use of ivabradine in catecholamine-induced tachycardia after high-risk cardiac surgery.	Clinical research in cardiology : official journal of the German Cardiac Society 20101201
Ivabradine in patients with inappropriate sinus tachycardia.	Naunyn-Schmiedeberg's archives of pharmacology 20101201
Benefit of heart rate reduction in heart failure.	Current heart failure reports 20101201
Impact of ''off-label'' use of ivabradine on exercise capacity, gas exchange, functional class, quality of life, and neurohormonal modulation in patients with ischemic chronic heart failure.	Journal of cardiovascular pharmacology and therapeutics 20101201
Heart failure: A SHIFT from ion channels to clinical practice.	Nature reviews. Cardiology 20101201
Ivabradine in combination with a beta-blocker. Stable angina: do not use instead, of or, with a beta-blocker.	Prescrire international 20101201
Clinical trials update from the European Society of Cardiology Meeting 2010: SHIFT, PEARL-HF, STAR-heart, and HEBE-III.	European journal of heart failure 20101101
[Clinical study SHIFT-- ivabradine--a new therapeutic options.].	Kardiologia polska 20101101
Stable angina: role of ivabradine unchanged between 2006 and 2010.	Prescrire international 20101101
[Patients with cardiovascular risk. SH/fT study: mortality rate reduced by a fourth].	MMW Fortschritte der Medizin 20101007
Ivabradine in combination with beta-blocker therapy for the treatment of stable angina pectoris in every day clinical practice.	Clinical research in cardiology : official journal of the German Cardiac Society 20101001
Safety and effectiveness of ivabradine after cardiac transplantation.	Transplantation proceedings 20101001
[Clinical-hemodynamic and anti-ischemic effects ivabradine and nebivolol ischemic heart disease with left ventricular dysfunction].	Georgian medical news 20101001
[Ivabradine as treatment of inappropriate sinus tachycardia].	Medicina clinica 20100918
[Heart failure. Heart rate control prevents clinical complications].	MMW Fortschritte der Medizin 20100916
Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial.	Lancet (London, England) 20100911
Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study.	Lancet (London, England) 20100911
Ivabradine in heart failure--no paradigm SHIFT…yet.	Lancet (London, England) 20100911
Heart rate reduction with ivabradine improves erectile dysfunction in parallel to decrease in atherosclerotic plaque load in ApoE-knockout mice.	Atherosclerosis 20100901
Ivabradine: appropriate treatment for inappropriate sinus tachycardia.	Heart rhythm 20100901
Efficacy of ivabradine administration in patients affected by inappropriate sinus tachycardia.	Heart rhythm 20100901
[Antianginal efficacy of ivabradine in a very old patient with aortic stenosis: effects on cardiac output and transvalvular aortic gradients].	Giornale italiano di cardiologia (2006) 20100901
Conventional and novel drug therapeutics to relief myocardial ischemia.	Cardiovascular drugs and therapy 20100801
Inappropriate sinus tachycardia - successful treatment with ivabradine.	Kardiologia polska 20100801
A case of inappropriate sinus tachycardia after atrio-ventricular nodal reentrant tachycardia cryoablation successfully treated by ivabradine.	Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20100701
Efficacy of ivabradine in a case of inappropriate sinus tachycardia and ventricular dysfunction.	Journal of cardiovascular electrophysiology 20100701
Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression.	European heart journal 20100601
Ivabradine as a heart rate-lowering agent in a patient with end-stage renal failure after heart transplantation.	Kardiologia polska 20100601
Successful use of ivabradine in a case of exaggerated autonomic dysfunction.	Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20100601
[Stable angina pectoris. Effective symptom control and cardioprotection with ivabradine].	MMW Fortschritte der Medizin 20100527
Chronic heart rate reduction facilitates cardiomyocyte survival after myocardial infarction.	Anatomical record (Hoboken, N.J. : 2007) 20100501
Ivabradine versus bisoprolol.	Minerva cardioangiologica 20100401
Heart rate in ischemic heart disease. The innovation of ivabradine: more than pure heart rate reduction.	Advances in therapy 20100401
Comparison of ivabradine plus beta-blockers versus beta -blocker therapy only.	Cardiovascular journal of Africa 20100401
Ivabradine to treat inappropriate sinus tachycardia after the fast pathway ablation in a patient with severe pectus excavatum.	Pacing and clinical electrophysiology : PACE 20100301
Ivabradine: from molecular basis to clinical effectiveness.	Advances in therapy 20100301
[Heart rate: a risk factor or an epiphenomenon?].	Giornale italiano di cardiologia (2006) 20100301
The role of the funny current in pacemaker activity.	Circulation research 20100219
Effect of HCN channel inhibition on retinal morphology and function in normal and dystrophic rodents.	Investigative ophthalmology & visual science 20100201
Specific inhibition of HCN channels slows rhythm differently in atria, ventricle and outflow tract and stabilizes conduction in the anoxic-reoxygenated embryonic heart model.	Pharmacological research 20100101
Rationale and design of a randomized, double-blind, placebo-controlled outcome trial of ivabradine in chronic heart failure: the Systolic Heart Failure Treatment with the I(f) Inhibitor Ivabradine Trial (SHIFT).	European journal of heart failure 20100101
Funny channel-based pacemaking.	Heart rhythm 20100101
Efficacy of ivabradine, a selective I(f) inhibitor, in patients with chronic stable angina pectoris and diabetes mellitus.	The American journal of cardiology 20100101
[Ivabradine in the treatment of patients with angina pectoris: lessons of the BEAUTIFUL trial].	Kardiologiia 20100101
[Efficacy of ivabradine in combination therapy for complicated acute coronary syndrome in patients with type 2 diabetes mellitus].	Terapevticheskii arkhiv 20100101
Efficacy of ivabradine in four patients with inappropriate sinus tachycardia: a three month-long experience based on electrocardiographic, Holter monitoring, exercise tolerance and quality of life assessments.	Cardiology journal 20100101
[Effect of the I(f) channel blocker ivabradine on the parameters of external respiration function in patients with chronic obstructive pulmonary disease in its stable course period].	Terapevticheskii arkhiv 20100101
[Study evaluating the impact of a combination of inotropic support and heart rate control on prognosis and stabilization rate in patients with decompensated chronic heart failure (LEGION)].	Terapevticheskii arkhiv 20100101
[Investigation of pacemaker shift in the rabbit sinoatrial node using the optical mapping technique].	Biofizika 20100101
Cardiogenic shock due to tachycardiomyopathy after heart transplantation: successful treatment with ivabradine.	Cardiology 20100101
[Application of cardiac resynchronization therapy and ivabradine in a patient with chronic heart failure].	Kardiologiia 20100101
[Possibilities of if channels inhibitor ivabradine in complex treatment of survivors of myocardial infarction with stable angina].	Kardiologiia 20100101
I(f) inhibition in cardiovascular diseases.	Advances in pharmacology (San Diego, Calif.) 20100101
Inotropic effects of ivabradine in the mammalian heart.	Pharmacology 20100101
SHIFTING the burden of heart failure.	Cardiovascular journal of Africa 20100101
[Dynamics of structural functional parameters of cardiovascular system in patients with Stable Angina and Congestive Heart Failure treated with Ivabradine for six months].	Kardiologiia 20100101
[The efficacy and safety of the combination of β-blocker bisoprolol and if inhibitor I(f) ivabradine in patients with stable angina and chronic obstructive pulmonary disease].	Kardiologiia 20100101
[Ivabradine in coronary heart disease: experimental and clinical pharmacology].	Therapie 20100101
Ivabradine reduces chemokine-induced CD4-positive lymphocyte migration.	Mediators of inflammation 20100101
Heart rate reduction by ivabradine reduces diastolic dysfunction and cardiac fibrosis.	Cardiology 20100101
[Antianginal efficacy and tolerability of ivabradine in the therapy of patients with stable angina: results of the CONTROL study].	Kardiologiia 20100101
Comparison of ivabradine versus metoprolol in early phases of reperfused anterior myocardial infarction with impaired left ventricular function: preliminary findings.	Journal of cardiac failure 20091201
Heart rate reduction with ivabradine improves energy metabolism and mechanical function of isolated ischaemic rabbit heart.	Cardiovascular research 20091001
Vascular endothelial ageing, heartbeat after heartbeat.	Cardiovascular research 20091001
'Funny' current: if heart rate slowing is not the best answer, what might be?	Cardiovascular research 20091001
Effects of selective I f-channel inhibition with ivabradine on hemodynamics in a patient with restrictive cardiomyopathy.	Clinical research in cardiology : official journal of the German Cardiac Society 20091001
Relationship between ivabradine treatment and cardiovascular outcomes in patients with stable coronary artery disease and left ventricular systolic dysfunction with limiting angina: a subgroup analysis of the randomized, controlled BEAUTIFUL trial.	European heart journal 20091001
A BEAUTIFUL lesson--ivabradine protects from ischaemia, but not from heart failure: through heart rate reduction or more?	European heart journal 20091001
Treatment of stable angina pectoris by ivabradine in every day practice: the REDUCTION study.	American heart journal 20091001
Arrhythmic effects of ivabradine in patients with coronary artery disease.	Clinical and investigative medicine. Medecine clinique et experimentale 20091001
New pharmacological agents for arrhythmias.	Circulation. Arrhythmia and electrophysiology 20091001
Heart rate reduction for 12 months with ivabradine reduces left ventricular mass in cardiac allograft recipients.	Transplantation 20090927
Effect of ivabradine in dobutamine induced sinus tachycardia in a case of acute heart failure.	Clinical research in cardiology : official journal of the German Cardiac Society 20090801
Postmyocardial infarction remodeling and coronary reserve: effects of ivabradine and beta blockade therapy.	American journal of physiology. Heart and circulatory physiology 20090701
A case of cardiomyopathy induced by inappropriate sinus tachycardia and cured by ivabradine.	Pacing and clinical electrophysiology : PACE 20090701
Heart rate reduction by I(f)-channel inhibition and its potential role in heart failure with reduced and preserved ejection fraction.	Trends in cardiovascular medicine 20090701
Randomised, double-blind, placebo-controlled trial of ivabradine in patients with acute coronary syndrome: effects of the If current inhibitor ivabradine on reduction of inflammation markers in patients with acute coronary syndrome--RIVIERA trial study design and rationale.	Cardiovascular drugs and therapy 20090601
[Ivabradine, an I(f) current inhibitor--new treatment options in coronary heart disease].	Revue medicale suisse 20090527
Angina: Ivabradine for treatment of stable angina pectoris.	Nature reviews. Cardiology 20090501
Ivabradine as a treatment option for inappropriate sinus tachycardia.	Revista espanola de cardiologia 20090501
[Ivabradine - a new therapeutic option for cardiogenic shock?].	Herz 20090501
[Ivabradine in patients with stable ischemic heart disease and left ventricular systolic dysfunction: the results of the BEAUTIFUL study].	Vnitrni lekarstvi 20090501
Selective Hcn1 channels inhibition by ivabradine in mouse rod photoreceptors.	Investigative ophthalmology & visual science 20090401
Interpreting clinical trials: the 'beautiful' case.	Fundamental & clinical pharmacology 20090401
Ivabradine - the beauty of a slow heart rate.	International journal of clinical practice 20090401
[The BEAUTIFUL study].	Giornale italiano di cardiologia (2006) 20090401
Multiple coronary to left ventricular fistulae.	European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 20090301
Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.	Journal of molecular and cellular cardiology 20090301
Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial.	European heart journal 20090301
A new combination therapy in stable angina pectoris.	European heart journal 20090301
Beneficial effects of delayed ivabradine treatment on cardiac anatomical and electrical remodeling in rat severe chronic heart failure.	American journal of physiology. Heart and circulatory physiology 20090201
Focus on ivabradine: a new heart rate-controlling drug.	Expert review of cardiovascular therapy 20090201
Review of the If selective channel inhibitor ivabradine in the treatment of chronic stable angina.	Advances in therapy 20090201
Ca2+: is there something new for the cardiovascular anesthesiologist?	Current opinion in anaesthesiology 20090201
Influence of heart rate reduction on Doppler myocardial imaging parameters in a small animal model.	Ultrasound in medicine & biology 20090101
Effects of ivabradine and metoprolol on cardiac angiogenesis and endothelial dysfunction in rats with heart failure.	Journal of cardiovascular pharmacology 20090101
Treatment of inappropriate sinus tachycardia with ivabradine in a patient with postural orthostatic tachycardia syndrome and a dual chamber pacemaker.	Pacing and clinical electrophysiology : PACE 20090101
Ivabradine: cardiovascular effects.	Recent patents on cardiovascular drug discovery 20090101
Ivabradine: beyond heart rate control.	Advances in therapy 20090101
[Antianginal effect of long-term use of ivabradine in patients with ischemic heart disease and diabetes in ambulatory conditions].	Kardiologiia 20090101
Ivabradine - a first-in-its-class treatment for lowering heart rate.	Cardiovascular journal of Africa 20090101
Effect of ivabradine, a novel antianginal agent, on driving performance: A randomized, double-blind, placebo-controlled trial in healthy volunteers.	Clinical drug investigation 20090101
[Heart rate control: f-channel blockers].	Fiziologiia cheloveka 20090101
Efficacy of I(f) inhibition with ivabradine in different subpopulations with stable angina pectoris.	Cardiology 20090101
Heart rate as a treatable cardiovascular risk factor.	British medical bulletin 20090101
Heart rate in coronary syndromes and heart failure.	Progress in cardiovascular diseases 20090101
Elevated heart rate in cardiovascular diseases: a target for treatment?	Progress in cardiovascular diseases 20090101
[Efficacy of therapy with bisoprolol and ivabradine in patients with ischemic heart disease combined with chronic obstructive pulmonary disease assessment of parameters of 24-hour ECG monitoring].	Kardiologiia 20090101
[Heart rate reduction: beneficial effects in heart failure and post-infarcted myocardium].	Therapie 20090101
Impact of a pure reduction in heart rate for the treatment of left ventricular dysfunction: clinical benefits of ivabradine in the BEAUTIFUL trial.	Therapie 20090101
Lessons from the BEAUTIfUL trial.	Cardiovascular journal of Africa 20090101
Ivabradine use in refractory unstable angina: a case report.	International journal of immunopathology and pharmacology 20090101
Ivabradine reduces cardiovascular events in angina patients.	Cardiovascular journal of Africa 20090101
Treatment of inappropriate sinus tachycardia with ivabradine.	Wiener klinische Wochenschrift 20090101
Role of heart rate in cardiovascular diseases: how the results of the BEAUTIFUL study change clinical practice.	American journal of cardiovascular drugs : drugs, devices, and other interventions 20090101
Ivabradine in heart failure: what about digoxin?	Lancet (London, England) 20081220
Pleiotropic action(s) of the bradycardic agent ivabradine: cardiovascular protection beyond heart rate reduction.	British journal of pharmacology 20081201
Clinical trials update from European Society of Cardiology meeting 2008: TIME-CHF, BACH, BEAUTIFUL, GISSI-HF, and HOME-HF.	European journal of heart failure 20081201
Ivabradine induces an increase in ventricular fibrillation threshold during acute myocardial ischemia: an experimental study.	Journal of cardiovascular pharmacology 20081201
Effects of ivabradine on allograft function and exercise performance in heart transplant recipients with permanent sinus tachycardia.	Clinical research in cardiology : official journal of the German Cardiac Society 20081101
Ivabradine for stable angina?	Drug and therapeutics bulletin 20081101
Ivabradine: pharmacodynamic aspects of its clinical use.	Methods and findings in experimental and clinical pharmacology 20081001
[Coronary heart disease. Rapid heart rate has an unfavorable prognosis].	MMW Fortschritte der Medizin 20080918
Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial.	Lancet (London, England) 20080906
Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial.	Lancet (London, England) 20080906
BEAUTIFUL results--the slower, the better?	Lancet (London, England) 20080906
Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction.	European heart journal 20080901
Chronic stable angina pectoris.	Disease-a-month : DM 20080901
[What are the alternatives to betablockers in 2009?].	Revue medicale de Bruxelles 20080901
Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart.	Cardiovascular research 20080701
Absence of respiratory effects with ivabradine in patients with asthma.	British journal of clinical pharmacology 20080701
Direct evidence for calcium conductance of hyperpolarization-activated cyclic nucleotide-gated channels and human native If at physiological calcium concentrations.	Cardiovascular research 20080601
Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice.	British journal of pharmacology 20080601
Defying the economists: a decrease in heart rate improves not only cardiac but also endothelial function.	British journal of pharmacology 20080601
Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure.	European journal of heart failure 20080601
[Is resting heart rate a cardiovascular risk factor?].	Praxis 20080528
[Resting heart rate as prognostic parameter--a slow rate indicates strength].	MMW Fortschritte der Medizin 20080522
Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice.	Circulation 20080506
Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: benefit from selective bradycardic agents.	British journal of pharmacology 20080401
The role of heart rate reduction in angina management and beyond.	British journal of hospital medicine (London, England : 2005) 20080401
[Ivabradine (Procoralan)].	Revue medicale de Liege 20080401
Ivabradine: I(f) inhibition in the management of stable angina pectoris and other cardiovascular diseases.	Drugs of today (Barcelona, Spain : 1998) 20080301
HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with I(f) blockade.	Heart rhythm 20080201
[Effect of ivabradin on mechanism of inter-ventricle interaction and respiratory function in conditions of cardio-respiratory pathology (results of Russian pilot study)].	Voenno-meditsinskii zhurnal 20080201
Effect of long-term heart rate reduction by If current inhibition on pressure overload-induced heart failure in rats.	The Journal of pharmacology and experimental therapeutics 20080101
Ivabradine as an alternative therapeutic trial in the therapy of inappropriate sinus tachycardia: a case report.	Cardiology 20080101
I f inhibition with ivabradine : electrophysiological effects and safety.	Drug safety 20080101
Does ivabradine exhibit a role in the reduction of bladder overactivity?	International urology and nephrology 20080101
[Clinical efficacy of ivabradine in patients with ischemic heart disease in combination with chronic obstructive pulmonary disease].	Kardiologiia 20080101
[The program ALTERNATIVA--investigation of antianginal efficacy and tolerability of coraxan (ivabradine) and assessment of quality of life of patients with stable angina: results of an epidemiological stage].	Kardiologiia 20080101
[The role of beta-adrenoblockers and If-inhibitor ivabradine in lowering of rate of development of cardiac complications after carotid endarterectomy].	Kardiologiia 20080101
[Comparative efficacy of ivabradine and atenolol in correction of clinical and functional parameters in patients with stable effort angina].	Kardiologiia 20080101
[Clinical efficiency of ivabradine in patients with cardiorespiratory pathology].	Klinicheskaia meditsina 20080101
The BEAUTIFUL study: randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction - baseline characteristics of the study population.	Cardiology 20080101
[Experience of the use of ivabradine in clinical practice].	Kardiologiia 20080101
[Possibilities of the use of ivabradine in complex therapy acute coronary syndrome].	Kardiologiia 20080101
Characterization of the heart rate-lowering action of ivabradine, a selective I(f) current inhibitor.	American journal of therapeutics 20080101
Elevated heart rate proven to increase coronary events.	Cardiovascular journal of Africa 20080101
Going for gold, from Beijing to Munich, highlights from the ESC 2008 Congress: BEAUTIFUL, GISSI-HF, and potential new therapies for acute decompensated heart failure.	Cardiovascular therapeutics 20080101
Letters to the editor: comments on the BEAUTIfUL study.	Cardiovascular journal of Africa 20080101
[Effect of ivabradin and clopidogrel on platelet hemostasis indices in patients with acute coronary syndrome without ST-segment elevation and with concurrent cardiac insufficiency].	Likars'ka sprava 20080101
[Clinical efficacy of ivabradin and nebivolol addition in combined treatment of ischemic heart disease patients with left ventricular dysfunction].	Terapevticheskii arkhiv 20080101
Symptom improvement in postural orthostatic tachycardia syndrome with the sinus node blocker ivabradine.	Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20071201
The heart rate-lowering agent ivabradine inhibits the pacemaker current I(f) in human atrial myocytes.	Journal of cardiovascular electrophysiology 20071101
Heart rate reduction after heart transplantation with beta-blocker versus the selective If channel antagonist ivabradine.	Transplantation 20071027
Preservation of coronary reserve by ivabradine-induced reduction in heart rate in infarcted rats is associated with decrease in perivascular collagen.	American journal of physiology. Heart and circulatory physiology 20070701
Ivabradine: a new strategy for management of stable angina.	British journal of hospital medicine (London, England : 2005) 20070601
[Heart rate as a cardiovascular risk factor: potential clinical benefit with ivabradine].	Revue medicale suisse 20070530
Heart rate reduction via selective 'funny' channel blockers.	Current opinion in pharmacology 20070401
Selective inhibition of the pacemaker channel I(f) improves symptoms in severe dilated cardiomyopathy.	Clinical research in cardiology : official journal of the German Cardiac Society 20070401
Conversion of post-systolic wall thickening into ejectional thickening by selective heart rate reduction during myocardial stunning.	European heart journal 20070401
I(f) current and heart rate control.	Arquivos brasileiros de cardiologia 20070401
Heart rate reduction by inhibition of If or by beta-blockade has different effects on postsystolic wall thickening.	British journal of pharmacology 20070201
Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease.	Clinical cardiology 20070201
Heart failure management. Interview with Karl Swedberg.	Timely topics in medicine. Cardiovascular diseases 20070109
Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activity.	British journal of pharmacology 20070101
Antianginal efficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3-month randomised, double-blind, multicentre, noninferiority trial.	Drugs 20070101
Long-term safety and efficacy of ivabradine in patients with chronic stable angina.	Cardiology 20070101
If inhibition by Ivabradine. Foreword.	Drugs 20070101
The funny current: cellular basis for the control of heart rate.	Drugs 20070101
Preclinical results with I(f) current inhibition by ivabradine.	Drugs 20070101
Clinical results of I(f) current inhibition by ivabradine.	Drugs 20070101
Perspectives of I(f) inhibition by ivabradine in cardiology.	Drugs 20070101
[Selective and specific reduction in the heart rate: a promising direction in the creation of new cardiovascular drugs].	Eksperimental'naia i klinicheskaia farmakologiia 20070101
[New drugs; ivabradine].	Nederlands tijdschrift voor geneeskunde 20061202
Comparison of a beta-blocker and an If current inhibitor in rabbits with myocardial infarction.	The Journal of cardiovascular surgery 20061201
[Heart rate reduction as a therapeutic strategy: novel options].	Der Internist 20061201
[Ivabradine--a medical alternative for patients with chronic stable angina pectoris].	Ugeskrift for laeger 20061113
Rationale and design of a randomized, double-blind, placebo-controlled trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction: the morBidity-mortality EvAlUaTion of the I(f) inhibitor ivabradine in patients with coronary disease and left ventricULar dysfunction (BEAUTIFUL) study.	American heart journal 20061101
Ivabradine: a selective If current inhibitor in the treatment of stable angina.	Recent patents on cardiovascular drug discovery 20061101
Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: an open-label, pharmacokinetic interaction clinical trial.	Journal of clinical pharmacology 20061001
Lack of pharmacokinetic interaction between omeprazole or lansoprazole and ivabradine in healthy volunteers: an open-label, randomized, crossover, pharmacokinetic interaction clinical trial.	Journal of clinical pharmacology 20061001
Heart rate lowering by inhibition of the pacemaker current: a new therapeutic perspective in cardiovascular disease.	Cardiovascular & hematological agents in medicinal chemistry 20061001
Selective and specific I(f) inhibition: new perspectives for the treatment of stable angina.	Expert opinion on pharmacotherapy 20060601
Therapeutic effects of I(f) blockade: evidence and perspective.	Pharmacological research 20060501
The discovery of the selective I(f) current inhibitor ivabradine. A new therapeutic approach to ischemic heart disease.	Pharmacological research 20060501
Funny channels in the control of cardiac rhythm and mode of action of selective blockers.	Pharmacological research 20060501
Anti-ischaemic effect of ivabradine.	Pharmacological research 20060501
Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.	The Journal of physiology 20060415
Bradycardic and proarrhythmic properties of sinus node inhibitors.	Molecular pharmacology 20060401
[Possibilities of reducing heart rate by I(f)-channel inhibitors].	Medizinische Klinik (Munich, Germany : 1983) 20060322
Comparative effects of ivabradine, a selective heart rate-lowering agent, and propranolol on systemic and cardiac haemodynamics at rest and during exercise.	British journal of clinical pharmacology 20060201
Evolving treatment strategies for chronic refractory angina.	Expert opinion on pharmacotherapy 20060201
Ivabradine -- the first selective sinus node I(f) channel inhibitor in the treatment of stable angina.	International journal of clinical practice 20060201
[Selective I(f) channel inhibition: an alternative for treating coronary artery disease?].	Herz 20060201
Serious workings of the funny current.	Progress in biophysics and molecular biology 20060101
[The discovery of the selective If current inhibitor ivabradine (Procoralan): a new therapeutic approach to ischemic heart disease].	Medecine sciences : M/S 20060101
[A new medicine for treatment of stable angina pectoris].	Terapevticheskii arkhiv 20060101
If current inhibition: cellular basis and physiology.	Advances in cardiology 20060101
Heart rate reduction by pharmacological If current inhibition.	Advances in cardiology 20060101
Clinical perspectives of heart rate slowing for coronary event reduction and heart failure.	Advances in cardiology 20060101
Clinical effect of 'pure' heart rate slowing with a prototype If current inhibitor: placebo-controlled experience with ivabradine.	Advances in cardiology 20060101
Heart rate slowing versus other pharmacological antianginal strategies.	Advances in cardiology 20060101
Novel If current inhibitor ivabradine: safety considerations.	Advances in cardiology 20060101
Heart rate slowing for myocardial dysfunction/heart failure.	Advances in cardiology 20060101
Future directions: what data do we need?	Advances in cardiology 20060101
[Ivabradine--the first selective and specific I(f) inhibitor, novel preparation for treatment of stable angina].	Kardiologiia 20060101
[Ivabradin (coraxan). One more new approach to fighting myocardial ischemia in patients with ischemic heart disease].	Terapevticheskii arkhiv 20060101
Chronic heart rate reduction remodels ion channel transcripts in the mouse sinoatrial node but not in the ventricle.	Physiological genomics 20051214
Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina.	European heart journal 20051201
If at first you don't succeed try ... a new target in the treatment of angina.	European heart journal 20051201
Physiology and pharmacology of the cardiac pacemaker ('funny') current.	Pharmacology & therapeutics 20050701
Cardiac pacemaker I(f) current and its inhibition by heart rate-reducing agents.	Current medical research and opinion 20050701
[Ivabradine -- a novel approach for heart rate lowering].	Deutsche medizinische Wochenschrift (1946) 20050617
New agent ivabradine (Procoralan) for treatment of chronic stable angina.	Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20050101
Drug insight: If inhibitors as specific heart-rate-reducing agents.	Nature clinical practice. Cardiovascular medicine 20041201
Selective reduction of heart rate by ivabradine: effect on the visco-elastic arterial properties in rats.	Journal of hypertension 20040901
I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities.	British journal of pharmacology 20040501
Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure.	Circulation 20040406
Heart rate reduction during exercise-induced myocardial ischaemia and stunning.	European heart journal 20040401
Effect of graded heart rate reduction with ivabradine on myocardial oxygen consumption and diastolic time in exercising dogs.	The Journal of pharmacology and experimental therapeutics 20040101
Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.	Drugs 20040101
Pharmacokinetics-pharmacodynamics during drug development--an example from Servier: ivabradine.	Therapie 20040101
[Selection and pharmacological characterisation of Procoralan, a selective inhibitor of the pacemaker If current].	Therapie 20040101
Heart rate reduction: a potential target for the treatment of myocardial ischaemia.	Therapie 20040101
Anti-ischemic effects of ivabradine, a selective heart rate-reducing agent, in exercise-induced myocardial ischemia in pigs.	Journal of cardiovascular pharmacology 20031101
Sinus tachyarrhythmias and the specific bradycardic agents: a marriage made in heaven?	Journal of cardiovascular pharmacology and therapeutics 20030601
Antianginal and antiischemic effects of ivabradine, an I(f) inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial.	Circulation 20030218
Contributions of heart rate and contractility to myocardial oxygen balance during exercise.	American journal of physiology. Heart and circulatory physiology 20030201
Electrophysiological effects of a single intravenous administration of ivabradine (S 16257) in adult patients with normal baseline electrophysiology.	Drugs in R&D 20030101
Effect of chronic heart rate reduction with ivabradine on carotid and aortic structure and function in normotensive and hypertensive rats.	Journal of vascular research 20030101
A single intravenous dose of ivabradine, a novel I(f) inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction.	Cardiology 20030101
Clinical trial simulation using therapeutic effect modeling: application to ivabradine efficacy in patients with angina pectoris.	Journal of pharmacokinetics and pharmacodynamics 20020801
Differential effects of heart rate reduction and beta-blockade on left ventricular relaxation during exercise.	American journal of physiology. Heart and circulatory physiology 20020201
Effects of heart rate reduction with ivabradine on exercise-induced myocardial ischemia and stunning.	The Journal of pharmacology and experimental therapeutics 20011201
An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine.	Journal of pharmacokinetics and pharmacodynamics 20010201
Optimal design of a population pharmacodynamic experiment for ivabradine.	Pharmaceutical research 20010101

Ivabradine in systemic sclerosis related pulmonary arterial hypertension.

European journal of internal medicine 20121201

Ivabradine: a ray of hope for inappropriate sinus tachycardia.

Journal of the American College of Cardiology 20121009

Clinical efficacy of ivabradine in patients with inappropriate sinus tachycardia: a prospective, randomized, placebo-controlled, double-blind, crossover evaluation.

Journal of the American College of Cardiology 20121009

Ivabradine for chronic heart failure?

Drug and therapeutics bulletin 20121001

[New pharmacological approaches to ischemic heart disease].

Giornale italiano di cardiologia (2006) 20121001

Ivabradine reduces total hospital burden in heart failure.

Cardiovascular journal of Africa 20121001

Therapeutic effects of ivabradine on hemodynamic parameters and cardiotoxicity induced by doxorubicin treatment in rat.

Human & experimental toxicology 20120901

Beneficial effect of ivabradine in dilated cardiomyopathy from Becker muscular dystrophy.

Herz 20120901

Lasting reduction of heart transplant tachycardia with ivabradine is effective and well tolerated: results of 48-month study.

Clinical research in cardiology : official journal of the German Cardiac Society 20120801

Pharmacokinetic interaction between ivabradine and phenytoin in healthy subjects.

Clinical drug investigation 20120801

Safety and efficacy of oral ivabradine as a heart rate-reducing agent in patients undergoing CT coronary angiography.

The British journal of radiology 20120801

Safe and well-tolerated treatment with ivabradine in systemic sclerosis affected by pulmonary hypertension.

Clinical research in cardiology : official journal of the German Cardiac Society 20120701

Treating stable angina - is there a NICE way towards an international consensus?

International journal of clinical practice 20120701

The 2012 ESC Guidelines on Heart Failure.

European heart journal 20120701

Anti-inflammatory effects of ivabradine in patients with acute coronary syndrome: a pilot study.

International journal of cardiology 20120628

Role of heart rate as a marker and mediator of poor outcome for patients with heart failure.

Current heart failure reports 20120601

Differential effects of ivabradine and ryanodine on pacemaker activity in canine sinus node and purkinje fibers.

Journal of cardiovascular electrophysiology 20120601

Heart rate-lowering efficacy and respiratory safety of ivabradine in patients with obstructive airway disease: a randomized, double-blind, placebo-controlled, crossover study.

American journal of cardiovascular drugs : drugs, devices, and other interventions 20120601

[Ivabradine: heart rate reduction in coronary heart disease and chronic heart failure].

Medizinische Monatsschrift fur Pharmazeuten 20120601

Recent developments in the management of heart failure.

The Practitioner 20120601

Effects on outcomes of heart rate reduction by ivabradine in patients with congestive heart failure: is there an influence of beta-blocker dose?: findings from the SHIFT (Systolic Heart failure treatment with the I(f) inhibitor ivabradine Trial) study.

Journal of the American College of Cardiology 20120529

It is all about heart rate. Or is it?

Journal of the American College of Cardiology 20120529

Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis.

European heart journal 20120501

Ivabradine in combination with beta-blocker improves symptoms and quality of life in patients with stable angina pectoris: results from the ADDITIONS study.

Clinical research in cardiology : official journal of the German Cardiac Society 20120501

Should we SHIFT our thinking about digoxin? Observations on ivabradine and heart rate reduction in heart failure.

European heart journal 20120501

Role of heart rate reduction in the prevention of experimental heart failure: comparison between If-channel blockade and β-receptor blockade.

Hypertension (Dallas, Tex. : 1979) 20120501

Heart rate reduction: an old and novel candidate heart failure therapy.

Hypertension (Dallas, Tex. : 1979) 20120501

The biological effects of ivabradine in cardiovascular disease.

Molecules (Basel, Switzerland) 20120430

Incremental value and safety of oral ivabradine for heart rate reduction in computed tomography coronary angiography.

International journal of cardiology 20120405

β-blockers in stage B: a precursor of heart failure.

Heart failure clinics 20120401

Effect of ivabradine vs atenolol on heart rate and effort tolerance in patients with mild to moderate mitral stenosis and normal sinus rhythm.

Journal of cardiac failure 20120401

[Update coronary artery disease: important progresses in acute and chronic therapy].

MMW Fortschritte der Medizin 20120322

Long-term treatment with ivabradine in post-myocardial infarcted rats counteracts f-channel overexpression.

British journal of pharmacology 20120301

Heart rate reduction induced by the if current inhibitor ivabradine improves diastolic function and attenuates cardiac tissue hypoxia.

Journal of cardiovascular pharmacology 20120301

Effects of ivabradine on the pulmonary vein electrical activity and modulation of pacemaker currents and calcium homeostasis.

Journal of cardiovascular electrophysiology 20120201

The funny current (If): is it a novel antiarrhythmic target to treat atrial fibrillation?

Journal of cardiovascular electrophysiology 20120201

Increased time varying heart rate and cardiovascular risk in hypertension: benefit of selective I((f)) channel inhibitor?

Blood pressure 20120201

Effects of ivabradine on heart rate and left ventricular function in healthy cats and cats with hypertrophic cardiomyopathy.

American journal of veterinary research 20120201

Ivabradine versus metoprolol for heart rate reduction before coronary computed tomography angiography.

The American journal of cardiology 20120115

Dose-dependent protective effect of ivabradine against ischemia-reperfusion-induced renal injury in rats.

Kidney & blood pressure research 20120101

[Efficacy of ivabradine in patients with stable angina and comorbid chronic obstructive pulmonary disease].

Kardiologiia 20120101

[The SHIFT study: a shift in a correct direction].

Kardiologiia 20120101

Effects of treatment with ivabradine and atenolol on reproducibility of echocardiographic indices of left heart size and function in healthy cats.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20120101

Acquired haemophilia secondary to ivabradine presenting with acute respiratory distress syndrome.

BMJ case reports 20120101

Concomitant administration of different doses of simvastatin with ivabradine influence on PAI-1 and heart rate in normo- and hypercholesterolaemic rats.

TheScientificWorldJournal 20120101

Heart rate reduction by ivabradine improves aortic compliance in apolipoprotein E-deficient mice.

Journal of vascular research 20120101

Comparison of effects of ivabradine versus carvedilol in murine model with the Coxsackievirus B3-induced viral myocarditis.

PloS one 20120101

[Pharmacological correction of heart rate in myocardial ischemia].

Terapevticheskii arkhiv 20120101

The 'funny' current (I(f)) inhibition by ivabradine at membrane potentials encompassing spontaneous depolarization in pacemaker cells.

Molecules (Basel, Switzerland) 20120101

[Effect of ivabradine on pulmonary hypertension in chronic obstructive pulmonary disease].

Kardiologiia 20120101

[Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and health related quality of life: results from the SHIFT substudies].

Vnitrni lekarstvi 20120101

Ivabradine and nightmares: a previously unreported adverse reaction.

European journal of clinical pharmacology 20111201

Efficacy of ivabradine in combination with Beta-blocker versus uptitration of Beta-blocker in patients with stable angina.

Cardiovascular drugs and therapy 20111201

Limited role for ivabradine in the treatment of chronic heart failure.

Heart (British Cardiac Society) 20111201

Beta-blocker dose up-titration or addition of ivabradine in stable angina: more is not necessarily better : editorial to: 'efficacy of ivabradine in combination with beta-blocker versus uptitration of beta-blocker in patients with stable angina' by E. Amosova et al.

Cardiovascular drugs and therapy 20111201

Pharmacodynamic effects of ivabradine, a negative chronotropic agent, in healthy cats.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20111201

Heart rate-associated mechanical stress impairs carotid but not cerebral artery compliance in dyslipidemic atherosclerotic mice.

American journal of physiology. Heart and circulatory physiology 20111101

Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress.

Basic research in cardiology 20111101

Natural history of end-stage LV dysfunction: has it improved from the classic Franciosa and Cohn Graph?

Cardiology clinics 20111101

[Ivabradine (pure heart-rate-lowering agent)].

Nihon rinsho. Japanese journal of clinical medicine 20111101

Electrophysiological effects of ivabradine in dog and human cardiac preparations: potential antiarrhythmic actions.

European journal of pharmacology 20111015

Pharmacokinetics of oral ivabradine in healthy cats.

Journal of veterinary pharmacology and therapeutics 20111001

Reducing elevated heart rate in patients with multiple organ dysfunction syndrome by the I (f) (funny channel current) inhibitor ivabradine : MODI (f)Y trial.

Clinical research in cardiology : official journal of the German Cardiac Society 20111001

Left ventricular remodelling in systolic heart failure using ivabradine. Slower is smaller is better?

European heart journal 20111001

Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy.

European heart journal 20111001

Heart rate reduction with ivabradine and health related quality of life in patients with chronic heart failure: results from the SHIFT study.

European heart journal 20111001

The importance of reducing heart rate in cardiovascular diseases: effects of Ivabradine.

Minerva medica 20111001

Effect of Carvedilol, Ivabradine or their combination on exercise capacity in patients with Heart Failure (the CARVIVA HF trial).

International journal of cardiology 20110901

A pediatric case of cardiomyopathy induced by inappropriate sinus tachycardia: efficacy of ivabradine.

Pediatric cardiology 20110801

Heart rate reduction with ivabradine increases ischaemia-induced ventricular fibrillation threshold: role of myocyte structure and myocardial perfusion.

Resuscitation 20110801

Ivabradine, a novel heart rate slower: is it a sword of double blades in patients with idiopathic dilated cardiomyopathy?

Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20110801

Medical therapy versus myocardial revascularization in chronic coronary syndrome and stable angina.

The American journal of medicine 20110801

Selective and specific I(f) inhibition with ivabradine: new perspectives for the treatment of cardiovascular disease.

Expert review of cardiovascular therapy 20110801

[New agents for the therapy of angina pectoris].

Der Internist 20110701

[Angina pectoris: improving symptoms and prognosis. With ivabradine less angina pectoris and reduced need for nitrates].

MMW Fortschritte der Medizin 20110616

[Reducing heart rate to treat angina pectoris].

Revue medicale suisse 20110608

Heart rate contributes to the vascular effects of chronic mental stress: effects on endothelial function and ischemic brain injury in mice.

Stroke 20110601

Ivabradine added to guidelines-based therapy in systolic heart failure patients.

Internal and emergency medicine 20110601

Heart rate: a forgotten link in coronary artery disease?

Nature reviews. Cardiology 20110426

Pharmacokinetic interaction between ivabradine and carbamazepine in healthy volunteers.

Journal of clinical pharmacy and therapeutics 20110401

[Heart failure].

Deutsche medizinische Wochenschrift (1946) 20110401

[New therapeutic approaches in heart failure].

Deutsche medizinische Wochenschrift (1946) 20110401

The use of ivabradine for inappropriate sinus tachycardia.

Acta cardiologica 20110401

Safety of ivabradine in patients with coronary artery disease and left ventricular systolic dysfunction (from the BEAUTIFUL Holter Substudy).

The American journal of cardiology 20110315

Reversal of tachycardiomyopathy due to left atrial tachycardia by ivabradine.

Journal of cardiovascular electrophysiology 20110301

Single centre experience of ivabradine in postural orthostatic tachycardia syndrome.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20110301

Ivabradine improves coronary flow reserve in patients with stable coronary artery disease.

Atherosclerosis 20110301

Ivabradine: an hypothesis generating study--an important link between bench and bedside.

Atherosclerosis 20110301

Ivabradine reduces heart rate while preserving metabolic fluxes and energy status of healthy normoxic working hearts.

American journal of physiology. Heart and circulatory physiology 20110301

Ivabradine in the treatment of orthostatic intolerance.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20110301

Innovation in coronary artery disease and heart failure: clinical benefits of pure heart rate reduction with ivabradine.

Annals of the New York Academy of Sciences 20110301

Effect of heart rate reduction by ivabradine on left ventricular remodeling in the echocardiographic substudy of BEAUTIFUL.

International journal of cardiology 20110203

Ivabradine for the treatment of stable angina pectoris in octogenarians.

Clinical research in cardiology : official journal of the German Cardiac Society 20110201

[Postural orthostatic tachycardia syndrome: current concepts in pathophysiology, diagnosis and therapeutic options].

Fortschritte der Neurologie-Psychiatrie 20110201

Ivabradine: recent and potential applications in clinical practice.

Expert opinion on pharmacotherapy 20110201

Heart rate decrease: a new paradigm in the treatment of heart failure. Insights from the SHIFT study.

Archives of cardiovascular diseases 20110201

Reversal of cardiomyopathy with ivabradine.

Internal medicine journal 20110201

Heart rate reduction with ivabradine prevents the global phenotype of left ventricular remodeling.

American journal of physiology. Heart and circulatory physiology 20110101

Heart rate and heart failure. Not a simple relationship.

Circulation journal : official journal of the Japanese Circulation Society 20110101

Rate control with ivabradine: angina pectoris and beyond.

American journal of cardiovascular drugs : drugs, devices, and other interventions 20110101

[Ivabradine].

Perspective infirmiere : revue officielle de l'Ordre des infirmieres et infirmiers du Quebec 20110101

Comparison of the effects of ivabradine and atenolol on heart rate and echocardiographic variables of left heart function in healthy cats.

Journal of veterinary internal medicine 20110101

[The SHIFT study].

Giornale italiano di cardiologia (2006) 20110101

Spironolactone diminishes spontaneous ventricular premature beats by reducing HCN4 protein expression in rats with myocardial infarction.

Molecular medicine reports 20110101

[From results of BEAUTIFUL trial to results of SHIFT trial: BEAUTIFUL possibility to make a SHIFT in current guidelines].

Kardiologiia 20110101

Heart failure: ivabradine is no better than optimised beta-blocker therapy.

Prescrire international 20110101

Selective pharmacological inhibition of the pacemaker channel isoforms (HCN1-4) as new possible therapeutical targets.

Current medicinal chemistry 20110101

Cardioprotection by ivabradine through heart rate reduction and beyond.

Journal of cardiovascular pharmacology and therapeutics 20110101

New data support ivabradine use in chronic heart failure.

Cardiovascular journal of Africa 20110101

[Alternative therapy with ivabradine in patients with functional class III chronic heart failure].

Kardiologiia 20110101

[Efficacy of ivabradin in combined treatment of patients with postinfarction systolic chronic cardiac failure].

Terapevticheskii arkhiv 20110101

Ivabradine and outcomes in chronic heart failure.

Lancet (London, England) 20101218

Ivabradine and outcomes in chronic heart failure.

Lancet (London, England) 20101218

Use of ivabradine in catecholamine-induced tachycardia after high-risk cardiac surgery.

Clinical research in cardiology : official journal of the German Cardiac Society 20101201

Ivabradine in patients with inappropriate sinus tachycardia.

Naunyn-Schmiedeberg's archives of pharmacology 20101201

Benefit of heart rate reduction in heart failure.

Current heart failure reports 20101201

Impact of ''off-label'' use of ivabradine on exercise capacity, gas exchange, functional class, quality of life, and neurohormonal modulation in patients with ischemic chronic heart failure.

Journal of cardiovascular pharmacology and therapeutics 20101201

Heart failure: A SHIFT from ion channels to clinical practice.

Nature reviews. Cardiology 20101201

Ivabradine in combination with a beta-blocker. Stable angina: do not use instead, of or, with a beta-blocker.

Prescrire international 20101201

Clinical trials update from the European Society of Cardiology Meeting 2010: SHIFT, PEARL-HF, STAR-heart, and HEBE-III.

European journal of heart failure 20101101

[Clinical study SHIFT-- ivabradine--a new therapeutic options.].

Kardiologia polska 20101101

Stable angina: role of ivabradine unchanged between 2006 and 2010.

Prescrire international 20101101

[Patients with cardiovascular risk. SH/fT study: mortality rate reduced by a fourth].

MMW Fortschritte der Medizin 20101007

Ivabradine in combination with beta-blocker therapy for the treatment of stable angina pectoris in every day clinical practice.

Clinical research in cardiology : official journal of the German Cardiac Society 20101001

Safety and effectiveness of ivabradine after cardiac transplantation.

Transplantation proceedings 20101001

[Clinical-hemodynamic and anti-ischemic effects ivabradine and nebivolol ischemic heart disease with left ventricular dysfunction].

Georgian medical news 20101001

[Ivabradine as treatment of inappropriate sinus tachycardia].

Medicina clinica 20100918

[Heart failure. Heart rate control prevents clinical complications].

MMW Fortschritte der Medizin 20100916

Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial.

Lancet (London, England) 20100911

Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study.

Lancet (London, England) 20100911

Ivabradine in heart failure--no paradigm SHIFT…yet.

Lancet (London, England) 20100911

Heart rate reduction with ivabradine improves erectile dysfunction in parallel to decrease in atherosclerotic plaque load in ApoE-knockout mice.

Atherosclerosis 20100901

Ivabradine: appropriate treatment for inappropriate sinus tachycardia.

Heart rhythm 20100901

Efficacy of ivabradine administration in patients affected by inappropriate sinus tachycardia.

Heart rhythm 20100901

[Antianginal efficacy of ivabradine in a very old patient with aortic stenosis: effects on cardiac output and transvalvular aortic gradients].

Giornale italiano di cardiologia (2006) 20100901

Conventional and novel drug therapeutics to relief myocardial ischemia.

Cardiovascular drugs and therapy 20100801

Inappropriate sinus tachycardia - successful treatment with ivabradine.

Kardiologia polska 20100801

A case of inappropriate sinus tachycardia after atrio-ventricular nodal reentrant tachycardia cryoablation successfully treated by ivabradine.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20100701

Efficacy of ivabradine in a case of inappropriate sinus tachycardia and ventricular dysfunction.

Journal of cardiovascular electrophysiology 20100701

Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression.

European heart journal 20100601

Ivabradine as a heart rate-lowering agent in a patient with end-stage renal failure after heart transplantation.

Kardiologia polska 20100601

Successful use of ivabradine in a case of exaggerated autonomic dysfunction.

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20100601

[Stable angina pectoris. Effective symptom control and cardioprotection with ivabradine].

MMW Fortschritte der Medizin 20100527

Chronic heart rate reduction facilitates cardiomyocyte survival after myocardial infarction.

Anatomical record (Hoboken, N.J. : 2007) 20100501

Ivabradine versus bisoprolol.

Minerva cardioangiologica 20100401

Heart rate in ischemic heart disease. The innovation of ivabradine: more than pure heart rate reduction.

Advances in therapy 20100401

Comparison of ivabradine plus beta-blockers versus beta -blocker therapy only.

Cardiovascular journal of Africa 20100401

Ivabradine to treat inappropriate sinus tachycardia after the fast pathway ablation in a patient with severe pectus excavatum.

Pacing and clinical electrophysiology : PACE 20100301

Ivabradine: from molecular basis to clinical effectiveness.

Advances in therapy 20100301

[Heart rate: a risk factor or an epiphenomenon?].

Giornale italiano di cardiologia (2006) 20100301

The role of the funny current in pacemaker activity.

Circulation research 20100219

Effect of HCN channel inhibition on retinal morphology and function in normal and dystrophic rodents.

Investigative ophthalmology & visual science 20100201

Specific inhibition of HCN channels slows rhythm differently in atria, ventricle and outflow tract and stabilizes conduction in the anoxic-reoxygenated embryonic heart model.

Pharmacological research 20100101

Rationale and design of a randomized, double-blind, placebo-controlled outcome trial of ivabradine in chronic heart failure: the Systolic Heart Failure Treatment with the I(f) Inhibitor Ivabradine Trial (SHIFT).

European journal of heart failure 20100101

Funny channel-based pacemaking.

Heart rhythm 20100101

Efficacy of ivabradine, a selective I(f) inhibitor, in patients with chronic stable angina pectoris and diabetes mellitus.

The American journal of cardiology 20100101

[Ivabradine in the treatment of patients with angina pectoris: lessons of the BEAUTIFUL trial].

Kardiologiia 20100101

[Efficacy of ivabradine in combination therapy for complicated acute coronary syndrome in patients with type 2 diabetes mellitus].

Terapevticheskii arkhiv 20100101

Efficacy of ivabradine in four patients with inappropriate sinus tachycardia: a three month-long experience based on electrocardiographic, Holter monitoring, exercise tolerance and quality of life assessments.

Cardiology journal 20100101

[Effect of the I(f) channel blocker ivabradine on the parameters of external respiration function in patients with chronic obstructive pulmonary disease in its stable course period].

Terapevticheskii arkhiv 20100101

[Study evaluating the impact of a combination of inotropic support and heart rate control on prognosis and stabilization rate in patients with decompensated chronic heart failure (LEGION)].

Terapevticheskii arkhiv 20100101

[Investigation of pacemaker shift in the rabbit sinoatrial node using the optical mapping technique].

Biofizika 20100101

Cardiogenic shock due to tachycardiomyopathy after heart transplantation: successful treatment with ivabradine.

Cardiology 20100101

[Application of cardiac resynchronization therapy and ivabradine in a patient with chronic heart failure].

Kardiologiia 20100101

[Possibilities of if channels inhibitor ivabradine in complex treatment of survivors of myocardial infarction with stable angina].

Kardiologiia 20100101

I(f) inhibition in cardiovascular diseases.

Advances in pharmacology (San Diego, Calif.) 20100101

Inotropic effects of ivabradine in the mammalian heart.

Pharmacology 20100101

SHIFTING the burden of heart failure.

Cardiovascular journal of Africa 20100101

[Dynamics of structural functional parameters of cardiovascular system in patients with Stable Angina and Congestive Heart Failure treated with Ivabradine for six months].

Kardiologiia 20100101

[The efficacy and safety of the combination of β-blocker bisoprolol and if inhibitor I(f) ivabradine in patients with stable angina and chronic obstructive pulmonary disease].

Kardiologiia 20100101

[Ivabradine in coronary heart disease: experimental and clinical pharmacology].

Therapie 20100101

Ivabradine reduces chemokine-induced CD4-positive lymphocyte migration.

Mediators of inflammation 20100101

Heart rate reduction by ivabradine reduces diastolic dysfunction and cardiac fibrosis.

Cardiology 20100101

[Antianginal efficacy and tolerability of ivabradine in the therapy of patients with stable angina: results of the CONTROL study].

Kardiologiia 20100101

Comparison of ivabradine versus metoprolol in early phases of reperfused anterior myocardial infarction with impaired left ventricular function: preliminary findings.

Journal of cardiac failure 20091201

Heart rate reduction with ivabradine improves energy metabolism and mechanical function of isolated ischaemic rabbit heart.

Cardiovascular research 20091001

Vascular endothelial ageing, heartbeat after heartbeat.

Cardiovascular research 20091001

'Funny' current: if heart rate slowing is not the best answer, what might be?

Cardiovascular research 20091001

Effects of selective I f-channel inhibition with ivabradine on hemodynamics in a patient with restrictive cardiomyopathy.

Clinical research in cardiology : official journal of the German Cardiac Society 20091001

Relationship between ivabradine treatment and cardiovascular outcomes in patients with stable coronary artery disease and left ventricular systolic dysfunction with limiting angina: a subgroup analysis of the randomized, controlled BEAUTIFUL trial.

European heart journal 20091001

A BEAUTIFUL lesson--ivabradine protects from ischaemia, but not from heart failure: through heart rate reduction or more?

European heart journal 20091001

Treatment of stable angina pectoris by ivabradine in every day practice: the REDUCTION study.

American heart journal 20091001

Arrhythmic effects of ivabradine in patients with coronary artery disease.

Clinical and investigative medicine. Medecine clinique et experimentale 20091001

New pharmacological agents for arrhythmias.

Circulation. Arrhythmia and electrophysiology 20091001

Heart rate reduction for 12 months with ivabradine reduces left ventricular mass in cardiac allograft recipients.

Transplantation 20090927

Effect of ivabradine in dobutamine induced sinus tachycardia in a case of acute heart failure.

Clinical research in cardiology : official journal of the German Cardiac Society 20090801

Postmyocardial infarction remodeling and coronary reserve: effects of ivabradine and beta blockade therapy.

American journal of physiology. Heart and circulatory physiology 20090701

A case of cardiomyopathy induced by inappropriate sinus tachycardia and cured by ivabradine.

Pacing and clinical electrophysiology : PACE 20090701

Heart rate reduction by I(f)-channel inhibition and its potential role in heart failure with reduced and preserved ejection fraction.

Trends in cardiovascular medicine 20090701

Randomised, double-blind, placebo-controlled trial of ivabradine in patients with acute coronary syndrome: effects of the If current inhibitor ivabradine on reduction of inflammation markers in patients with acute coronary syndrome--RIVIERA trial study design and rationale.

Cardiovascular drugs and therapy 20090601

[Ivabradine, an I(f) current inhibitor--new treatment options in coronary heart disease].

Revue medicale suisse 20090527

Angina: Ivabradine for treatment of stable angina pectoris.

Nature reviews. Cardiology 20090501

Ivabradine as a treatment option for inappropriate sinus tachycardia.

Revista espanola de cardiologia 20090501

[Ivabradine - a new therapeutic option for cardiogenic shock?].

Herz 20090501

[Ivabradine in patients with stable ischemic heart disease and left ventricular systolic dysfunction: the results of the BEAUTIFUL study].

Vnitrni lekarstvi 20090501

Selective Hcn1 channels inhibition by ivabradine in mouse rod photoreceptors.

Investigative ophthalmology & visual science 20090401

Interpreting clinical trials: the 'beautiful' case.

Fundamental & clinical pharmacology 20090401

Ivabradine - the beauty of a slow heart rate.

International journal of clinical practice 20090401

[The BEAUTIFUL study].

Giornale italiano di cardiologia (2006) 20090401

Multiple coronary to left ventricular fistulae.

European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 20090301

Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.

Journal of molecular and cellular cardiology 20090301

Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial.

European heart journal 20090301

A new combination therapy in stable angina pectoris.

European heart journal 20090301

Beneficial effects of delayed ivabradine treatment on cardiac anatomical and electrical remodeling in rat severe chronic heart failure.

American journal of physiology. Heart and circulatory physiology 20090201

Focus on ivabradine: a new heart rate-controlling drug.

Expert review of cardiovascular therapy 20090201

Review of the If selective channel inhibitor ivabradine in the treatment of chronic stable angina.

Advances in therapy 20090201

Ca2+: is there something new for the cardiovascular anesthesiologist?

Current opinion in anaesthesiology 20090201

Influence of heart rate reduction on Doppler myocardial imaging parameters in a small animal model.

Ultrasound in medicine & biology 20090101

Effects of ivabradine and metoprolol on cardiac angiogenesis and endothelial dysfunction in rats with heart failure.

Journal of cardiovascular pharmacology 20090101

Treatment of inappropriate sinus tachycardia with ivabradine in a patient with postural orthostatic tachycardia syndrome and a dual chamber pacemaker.

Pacing and clinical electrophysiology : PACE 20090101

Ivabradine: cardiovascular effects.

Recent patents on cardiovascular drug discovery 20090101

Ivabradine: beyond heart rate control.

Advances in therapy 20090101

[Antianginal effect of long-term use of ivabradine in patients with ischemic heart disease and diabetes in ambulatory conditions].

Kardiologiia 20090101

Ivabradine - a first-in-its-class treatment for lowering heart rate.

Cardiovascular journal of Africa 20090101

Effect of ivabradine, a novel antianginal agent, on driving performance: A randomized, double-blind, placebo-controlled trial in healthy volunteers.

Clinical drug investigation 20090101

[Heart rate control: f-channel blockers].

Fiziologiia cheloveka 20090101

Efficacy of I(f) inhibition with ivabradine in different subpopulations with stable angina pectoris.

Cardiology 20090101

Heart rate as a treatable cardiovascular risk factor.

British medical bulletin 20090101

Heart rate in coronary syndromes and heart failure.

Progress in cardiovascular diseases 20090101

Elevated heart rate in cardiovascular diseases: a target for treatment?

Progress in cardiovascular diseases 20090101

[Efficacy of therapy with bisoprolol and ivabradine in patients with ischemic heart disease combined with chronic obstructive pulmonary disease assessment of parameters of 24-hour ECG monitoring].

Kardiologiia 20090101

[Heart rate reduction: beneficial effects in heart failure and post-infarcted myocardium].

Therapie 20090101

Impact of a pure reduction in heart rate for the treatment of left ventricular dysfunction: clinical benefits of ivabradine in the BEAUTIFUL trial.

Therapie 20090101

Lessons from the BEAUTIfUL trial.

Cardiovascular journal of Africa 20090101

Ivabradine use in refractory unstable angina: a case report.

International journal of immunopathology and pharmacology 20090101

Ivabradine reduces cardiovascular events in angina patients.

Cardiovascular journal of Africa 20090101

Treatment of inappropriate sinus tachycardia with ivabradine.

Wiener klinische Wochenschrift 20090101

Role of heart rate in cardiovascular diseases: how the results of the BEAUTIFUL study change clinical practice.

American journal of cardiovascular drugs : drugs, devices, and other interventions 20090101

Ivabradine in heart failure: what about digoxin?

Lancet (London, England) 20081220

Pleiotropic action(s) of the bradycardic agent ivabradine: cardiovascular protection beyond heart rate reduction.

British journal of pharmacology 20081201

Clinical trials update from European Society of Cardiology meeting 2008: TIME-CHF, BACH, BEAUTIFUL, GISSI-HF, and HOME-HF.

European journal of heart failure 20081201

Ivabradine induces an increase in ventricular fibrillation threshold during acute myocardial ischemia: an experimental study.

Journal of cardiovascular pharmacology 20081201

Effects of ivabradine on allograft function and exercise performance in heart transplant recipients with permanent sinus tachycardia.

Clinical research in cardiology : official journal of the German Cardiac Society 20081101

Ivabradine for stable angina?

Drug and therapeutics bulletin 20081101

Ivabradine: pharmacodynamic aspects of its clinical use.

Methods and findings in experimental and clinical pharmacology 20081001

[Coronary heart disease. Rapid heart rate has an unfavorable prognosis].

MMW Fortschritte der Medizin 20080918

Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial.

Lancet (London, England) 20080906

Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial.

Lancet (London, England) 20080906

BEAUTIFUL results--the slower, the better?

Lancet (London, England) 20080906

Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction.

European heart journal 20080901

Chronic stable angina pectoris.

Disease-a-month : DM 20080901

[What are the alternatives to betablockers in 2009?].

Revue medicale de Bruxelles 20080901

Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart.

Cardiovascular research 20080701

Absence of respiratory effects with ivabradine in patients with asthma.

British journal of clinical pharmacology 20080701

Direct evidence for calcium conductance of hyperpolarization-activated cyclic nucleotide-gated channels and human native If at physiological calcium concentrations.

Cardiovascular research 20080601

Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice.

British journal of pharmacology 20080601

Defying the economists: a decrease in heart rate improves not only cardiac but also endothelial function.

British journal of pharmacology 20080601

Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure.

European journal of heart failure 20080601

[Is resting heart rate a cardiovascular risk factor?].

Praxis 20080528

[Resting heart rate as prognostic parameter--a slow rate indicates strength].

MMW Fortschritte der Medizin 20080522

Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice.

Circulation 20080506

Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: benefit from selective bradycardic agents.

British journal of pharmacology 20080401

The role of heart rate reduction in angina management and beyond.

British journal of hospital medicine (London, England : 2005) 20080401

[Ivabradine (Procoralan)].

Revue medicale de Liege 20080401

Ivabradine: I(f) inhibition in the management of stable angina pectoris and other cardiovascular diseases.

Drugs of today (Barcelona, Spain : 1998) 20080301

HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with I(f) blockade.

Heart rhythm 20080201

[Effect of ivabradin on mechanism of inter-ventricle interaction and respiratory function in conditions of cardio-respiratory pathology (results of Russian pilot study)].

Voenno-meditsinskii zhurnal 20080201

Effect of long-term heart rate reduction by If current inhibition on pressure overload-induced heart failure in rats.

The Journal of pharmacology and experimental therapeutics 20080101

Ivabradine as an alternative therapeutic trial in the therapy of inappropriate sinus tachycardia: a case report.

Cardiology 20080101

I f inhibition with ivabradine : electrophysiological effects and safety.

Drug safety 20080101

Does ivabradine exhibit a role in the reduction of bladder overactivity?

International urology and nephrology 20080101

[Clinical efficacy of ivabradine in patients with ischemic heart disease in combination with chronic obstructive pulmonary disease].

Kardiologiia 20080101

[The program ALTERNATIVA--investigation of antianginal efficacy and tolerability of coraxan (ivabradine) and assessment of quality of life of patients with stable angina: results of an epidemiological stage].

Kardiologiia 20080101

[The role of beta-adrenoblockers and If-inhibitor ivabradine in lowering of rate of development of cardiac complications after carotid endarterectomy].

Kardiologiia 20080101

[Comparative efficacy of ivabradine and atenolol in correction of clinical and functional parameters in patients with stable effort angina].

Kardiologiia 20080101

[Clinical efficiency of ivabradine in patients with cardiorespiratory pathology].

Klinicheskaia meditsina 20080101

The BEAUTIFUL study: randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction - baseline characteristics of the study population.

Cardiology 20080101

[Experience of the use of ivabradine in clinical practice].

Kardiologiia 20080101

[Possibilities of the use of ivabradine in complex therapy acute coronary syndrome].

Kardiologiia 20080101

Characterization of the heart rate-lowering action of ivabradine, a selective I(f) current inhibitor.

American journal of therapeutics 20080101

Elevated heart rate proven to increase coronary events.

Cardiovascular journal of Africa 20080101

Going for gold, from Beijing to Munich, highlights from the ESC 2008 Congress: BEAUTIFUL, GISSI-HF, and potential new therapies for acute decompensated heart failure.

Cardiovascular therapeutics 20080101

Letters to the editor: comments on the BEAUTIfUL study.

Cardiovascular journal of Africa 20080101

[Effect of ivabradin and clopidogrel on platelet hemostasis indices in patients with acute coronary syndrome without ST-segment elevation and with concurrent cardiac insufficiency].

Likars'ka sprava 20080101

[Clinical efficacy of ivabradin and nebivolol addition in combined treatment of ischemic heart disease patients with left ventricular dysfunction].

Terapevticheskii arkhiv 20080101

Symptom improvement in postural orthostatic tachycardia syndrome with the sinus node blocker ivabradine.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20071201

The heart rate-lowering agent ivabradine inhibits the pacemaker current I(f) in human atrial myocytes.

Journal of cardiovascular electrophysiology 20071101

Heart rate reduction after heart transplantation with beta-blocker versus the selective If channel antagonist ivabradine.

Transplantation 20071027

Preservation of coronary reserve by ivabradine-induced reduction in heart rate in infarcted rats is associated with decrease in perivascular collagen.

American journal of physiology. Heart and circulatory physiology 20070701

Ivabradine: a new strategy for management of stable angina.

British journal of hospital medicine (London, England : 2005) 20070601

[Heart rate as a cardiovascular risk factor: potential clinical benefit with ivabradine].

Revue medicale suisse 20070530

Heart rate reduction via selective 'funny' channel blockers.

Current opinion in pharmacology 20070401

Selective inhibition of the pacemaker channel I(f) improves symptoms in severe dilated cardiomyopathy.

Clinical research in cardiology : official journal of the German Cardiac Society 20070401

Conversion of post-systolic wall thickening into ejectional thickening by selective heart rate reduction during myocardial stunning.

European heart journal 20070401

I(f) current and heart rate control.

Arquivos brasileiros de cardiologia 20070401

Heart rate reduction by inhibition of If or by beta-blockade has different effects on postsystolic wall thickening.

British journal of pharmacology 20070201

Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease.

Clinical cardiology 20070201

Heart failure management. Interview with Karl Swedberg.

Timely topics in medicine. Cardiovascular diseases 20070109

Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activity.

British journal of pharmacology 20070101

Antianginal efficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3-month randomised, double-blind, multicentre, noninferiority trial.

Drugs 20070101

Long-term safety and efficacy of ivabradine in patients with chronic stable angina.

Cardiology 20070101

If inhibition by Ivabradine. Foreword.

Drugs 20070101

The funny current: cellular basis for the control of heart rate.

Drugs 20070101

Preclinical results with I(f) current inhibition by ivabradine.

Drugs 20070101

Clinical results of I(f) current inhibition by ivabradine.

Drugs 20070101

Perspectives of I(f) inhibition by ivabradine in cardiology.

Drugs 20070101

[Selective and specific reduction in the heart rate: a promising direction in the creation of new cardiovascular drugs].

Eksperimental'naia i klinicheskaia farmakologiia 20070101

[New drugs; ivabradine].

Nederlands tijdschrift voor geneeskunde 20061202

Comparison of a beta-blocker and an If current inhibitor in rabbits with myocardial infarction.

The Journal of cardiovascular surgery 20061201

[Heart rate reduction as a therapeutic strategy: novel options].

Der Internist 20061201

[Ivabradine--a medical alternative for patients with chronic stable angina pectoris].

Ugeskrift for laeger 20061113

Rationale and design of a randomized, double-blind, placebo-controlled trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction: the morBidity-mortality EvAlUaTion of the I(f) inhibitor ivabradine in patients with coronary disease and left ventricULar dysfunction (BEAUTIFUL) study.

American heart journal 20061101

Ivabradine: a selective If current inhibitor in the treatment of stable angina.

Recent patents on cardiovascular drug discovery 20061101

Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: an open-label, pharmacokinetic interaction clinical trial.

Journal of clinical pharmacology 20061001

Lack of pharmacokinetic interaction between omeprazole or lansoprazole and ivabradine in healthy volunteers: an open-label, randomized, crossover, pharmacokinetic interaction clinical trial.

Journal of clinical pharmacology 20061001

Heart rate lowering by inhibition of the pacemaker current: a new therapeutic perspective in cardiovascular disease.

Cardiovascular & hematological agents in medicinal chemistry 20061001

Selective and specific I(f) inhibition: new perspectives for the treatment of stable angina.

Expert opinion on pharmacotherapy 20060601

Therapeutic effects of I(f) blockade: evidence and perspective.

Pharmacological research 20060501

The discovery of the selective I(f) current inhibitor ivabradine. A new therapeutic approach to ischemic heart disease.

Pharmacological research 20060501

Funny channels in the control of cardiac rhythm and mode of action of selective blockers.

Pharmacological research 20060501

Anti-ischaemic effect of ivabradine.

Pharmacological research 20060501

Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.

The Journal of physiology 20060415

Bradycardic and proarrhythmic properties of sinus node inhibitors.

Molecular pharmacology 20060401

[Possibilities of reducing heart rate by I(f)-channel inhibitors].

Medizinische Klinik (Munich, Germany : 1983) 20060322

Comparative effects of ivabradine, a selective heart rate-lowering agent, and propranolol on systemic and cardiac haemodynamics at rest and during exercise.

British journal of clinical pharmacology 20060201

Evolving treatment strategies for chronic refractory angina.

Expert opinion on pharmacotherapy 20060201

Ivabradine -- the first selective sinus node I(f) channel inhibitor in the treatment of stable angina.

International journal of clinical practice 20060201

[Selective I(f) channel inhibition: an alternative for treating coronary artery disease?].

Herz 20060201

Serious workings of the funny current.

Progress in biophysics and molecular biology 20060101

[The discovery of the selective If current inhibitor ivabradine (Procoralan): a new therapeutic approach to ischemic heart disease].

Medecine sciences : M/S 20060101

[A new medicine for treatment of stable angina pectoris].

Terapevticheskii arkhiv 20060101

If current inhibition: cellular basis and physiology.