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Home > Fluorides > 147817-50-3
147817-50-3 | Spiro[isobenzofuran-1(3H),4'-piperidine], 1'-[4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl]-
CAS No: 147817-50-3 Catalog No: AG001F8P MDL No:
Product Description
Catalog Number:
AG001F8P
Chemical Name:
Spiro[isobenzofuran-1(3H),4'-piperidine], 1'-[4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl]-
CAS Number:
147817-50-3
Molecular Formula:
C30H31FN2O
Molecular Weight:
454.5783
IUPAC Name:
1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine]
InChI:
InChI=1S/C30H31FN2O/c31-25-12-14-26(15-13-25)33-21-23(27-9-2-4-11-29(27)33)7-5-6-18-32-19-16-30(17-20-32)28-10-3-1-8-24(28)22-34-30/h1-4,8-15,21H,5-7,16-20,22H2
InChI Key:
XWAONOGAGZNUSF-UHFFFAOYSA-N
SMILES:
Fc1ccc(cc1)n1cc(c2c1cccc2)CCCCN1CCC2(CC1)OCc1c2cccc1
UNII:
3IX8CWR24V
Properties
Complexity:
656
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
454.242g/mol
Formal Charge:
0
Heavy Atom Count:
34
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
454.589g/mol
Monoisotopic Mass:
454.242g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
17.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
6
Literature
| Title | Journal |
|---|---|
| Synthesis and pharmacological evaluation of indole-based sigma receptor ligands. | European journal of medicinal chemistry 20111001 |
| Acute effects of the sigma-2 receptor agonist siramesine on lysosomal and extra-lysosomal proteolytic systems in lens epithelial cells. | Molecular vision 20100101 |
| The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine. | Molecular cancer 20100101 |
| Influence of the solid form of siramesine hydrochloride on its behavior in aqueous environments. | Pharmaceutical research 20090401 |
| Adsorption of pharmaceutical excipients onto microcrystals of siramesine hydrochloride: effects on physicochemical properties. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090101 |
| Substituted benzylaminoalkylindoles with preference for the sigma2 binding site. | European journal of medicinal chemistry 20081001 |
| Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. | Autophagy 20080501 |
| Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine. | Cancer research 20070301 |
| The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060601 |
| Sigma2 (sigma2) receptors as a target for cocaine action in the rat striatum. | European journal of pharmacology 20060327 |
| Bioreversible quaternary N-acyloxymethyl derivatives of the poorly soluble tertiary amine Lu 28-179--synthesis, pharmaceutical chemical characterization and bioavailability studies in dogs. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20051201 |
| Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress. | Cancer research 20051001 |
| Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20041101 |
| Comparison of the lymphatic transport of a lipophilic drug from vehicles containing alpha-tocopherol and/or triglycerides in rats. | The Journal of pharmacy and pharmacology 20011101 |
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