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Home > Fluorides > 147511-69-1
147511-69-1 | 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, (3R,5S,6E)-
CAS No: 147511-69-1 Catalog No: AG001EXH MDL No:
Product Description
Catalog Number:
AG001EXH
Chemical Name:
6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, (3R,5S,6E)-
CAS Number:
147511-69-1
Molecular Formula:
C25H24FNO4
Molecular Weight:
421.4608
IUPAC Name:
(E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid
InChI:
InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/b12-11+/t18-,19-/m1/s1
InChI Key:
VGYFMXBACGZSIL-MCBHFWOFSA-N
SMILES:
O[C@H](C[C@@H](/C=C/c1c(nc2c(c1c1ccc(cc1)F)cccc2)C1CC1)O)CC(=O)O
UNII:
M5681Q5F9P
Properties
Complexity:
631
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
1
Exact Mass:
421.169g/mol
Formal Charge:
0
Heavy Atom Count:
31
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
421.468g/mol
Monoisotopic Mass:
421.169g/mol
Rotatable Bond Count:
8
Topological Polar Surface Area:
90.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.5
Literature
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|---|---|
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| Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects. | Journal of cardiovascular pharmacology 20120701 |
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| Statin-induced myotoxicity: pharmacokinetic differences among statins and the risk of rhabdomyolysis, with particular reference to pitavastatin. | Current vascular pharmacology 20120301 |
| Pitavastatin, a new HMG-CoA reductase inhibitor, induces phototoxicity in human keratinocytes NCTC-2544 through the formation of benzophenanthridine-like photoproducts. | Archives of toxicology 20120301 |
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| Qualitative plaque stabilization but not quantitative plaque regression. | Circulation journal : official journal of the Japanese Circulation Society 20120101 |
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| Clinically evident polyvascular disease and regression of coronary atherosclerosis after intensive statin therapy in patients with acute coronary syndrome: serial intravascular ultrasound from the Japanese assessment of pitavastatin and atorvastatin in acute coronary syndrome (JAPAN-ACS) trial. | Atherosclerosis 20111201 |
| Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice: protection by atorvastatin and pitavastatin. | Neuroscience 20111201 |
| Comparative long-term efficacy and tolerability of pitavastatin 4 mg and atorvastatin 20-40 mg in patients with type 2 diabetes mellitus and combined (mixed) dyslipidaemia. | Diabetes, obesity & metabolism 20111101 |
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| Statins induce apoptosis and inhibit proliferation in cholangiocarcinoma cells. | International journal of oncology 20110901 |
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| Drug-drug interactions with statins: will pitavastatin overcome the statins' Achilles' heel? | Current medical research and opinion 20110801 |
| Pitavastatin calcium: clinical review of a new antihyperlipidemic medication. | Clinical therapeutics 20110801 |
| Regulation mechanism of ABCA1 expression by statins in hepatocytes. | European journal of pharmacology 20110715 |
| Short-term effect of pitavastatin on the reactive hyperemic index in post-menopausal women with high levels in serum LDL-cholesterol. | International journal of cardiology 20110715 |
| Pitavastatin prevents postprandial endothelial dysfunction via reduction of the serum triglyceride level in obese male subjects. | Heart and vessels 20110701 |
| Distinct effects of pitavastatin and atorvastatin on lipoprotein subclasses in patients with Type 2 diabetes mellitus. | Diabetic medicine : a journal of the British Diabetic Association 20110701 |
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| Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF. | Laboratory investigation; a journal of technical methods and pathology 20110501 |
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| Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats. | Drug metabolism and disposition: the biological fate of chemicals 20110301 |
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| Inhibition of intestinal polyp formation by pitavastatin, a HMG-CoA reductase inhibitor. | Cancer prevention research (Philadelphia, Pa.) 20110301 |
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| Pitavastatin and 4'-hydroxy-3'-methoxyacetophenone (HMAP) reduce cognitive dysfunction in vascular dementia during experimental diabetes. | Current neurovascular research 20100801 |
| Nanoparticle-mediated endothelial cell-selective delivery of pitavastatin induces functional collateral arteries (therapeutic arteriogenesis) in a rabbit model of chronic hind limb ischemia. | Journal of vascular surgery 20100801 |
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| Pitavastatin strengthens the barrier integrity in primary cultures of rat brain endothelial cells. | Cellular and molecular neurobiology 20100701 |
| Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor and low-density lipoprotein on proliferation and migration of keratinocytes. | The British journal of dermatology 20100701 |
| Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice. | Cancer science 20100701 |
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| High density lipoprotein cholesterol and apolipoprotein A-I are persistently elevated during long-term treatment with pitavastatin, a new HMG-CoA reductase inhibitor. | International journal of cardiology 20100611 |
| Pitavastatin reduces oxidative stress and attenuates intermittent hypoxia-induced left ventricular remodeling in lean mice. | Hypertension research : official journal of the Japanese Society of Hypertension 20100601 |
| Diabetes mellitus is a major negative determinant of coronary plaque regression during statin therapy in patients with acute coronary syndrome--serial intravascular ultrasound observations from the Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome Trial (the JAPAN-ACS Trial). | Circulation journal : official journal of the Japanese Circulation Society 20100601 |
| Effects of three strong statins (atorvastatin, pitavastatin, and rosuvastatin) on serum uric acid levels in dyslipidemic patients. | Nucleosides, nucleotides & nucleic acids 20100601 |
| Long-term treatment with pitavastatin is effective and well tolerated by patients with primary hypercholesterolemia or combined dyslipidemia. | Atherosclerosis 20100501 |
| Endothelial nitric oxide synthase-independent protective action of statin against angiotensin II-induced atrial remodeling via reduced oxidant injury. | Hypertension (Dallas, Tex. : 1979) 20100401 |
| New evidence on pitavastatin: efficacy and safety in clinical studies. | Expert opinion on pharmacotherapy 20100401 |
| Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans. | Lipids 20100401 |
| Atherosclerosis induced by chronic inhibition of the synthesis of nitric oxide in moderately hypercholesterolaemic rabbits is suppressed by pitavastatin. | British journal of pharmacology 20100401 |
| Lack of effect of genetic polymorphisms of SLCO1B1 on the lipid-lowering response to pitavastatin in Chinese patients. | Acta pharmacologica Sinica 20100301 |
| Pitavastatin: a new HMG-CoA reductase inhibitor. | The Annals of pharmacotherapy 20100301 |
| Comparative efficacy and safety of low-dose pitavastatin versus atorvastatin in patients with hypercholesterolemia. | The Annals of pharmacotherapy 20100301 |
| S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. | Cardiovascular research 20100201 |
| OATP1B1 388A>G polymorphism and pharmacokinetics of pitavastatin in Chinese healthy volunteers. | Journal of clinical pharmacy and therapeutics 20100201 |
| Noninferiority of pitavastatin in intravascular ultrasound findings. | Journal of the American College of Cardiology 20100119 |
| Co-administration of ezetimibe enhances proteinuria-lowering effects of pitavastatin in chronic kidney disease patients partly via a cholesterol-independent manner. | Pharmacological research 20100101 |
| Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier. | Drug metabolism and disposition: the biological fate of chemicals 20100101 |
| Pitavastatin, an HMG-CoA reductase inhibitor, ameliorates endothelial function in chronic smokers. | Circulation journal : official journal of the Japanese Circulation Society 20100101 |
| New translational research on novel drugs for hepatitis C virus 1b infection by using a replicon system and human induced pluripotent stem cells. | Hepatology (Baltimore, Md.) 20100101 |
| An identification of the novel combination therapy for hepatitis C virus 1b infection by using a replicon system and human induced pluripotent stem cells. | Hepatology (Baltimore, Md.) 20100101 |
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| New drugs: pitavastatin calcium, vigabatrin, and romidepsin. | Journal of the American Pharmacists Association : JAPhA 20100101 |
| Pitavastatin: a new HMG-CoA reductase inhibitor for the treatment of hypercholesterolemia. | Cardiology in review 20100101 |
| Pitavastatin further decreases serum high-sensitive C-reactive protein levels in hypertensive patients with hypercholesterolemia treated with angiotensin II, type-1 receptor antagonists. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20100101 |
| Memory restorative role of statins in experimental dementia: an evidence of their cholesterol dependent and independent actions. | Pharmacological reports : PR 20100101 |
| Pitavastatin approved for treatment of primary hypercholesterolemia and combined dyslipidemia. | Vascular health and risk management 20100101 |
| Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones. | Bioorganic & medicinal chemistry 20091201 |
| A novel method in order to evaluate the efficacies and the safeties of new drugs for hepatocellular carcinoma with loss of transforming growth factor-beta signaling. | Hepatology (Baltimore, Md.) 20091201 |
| Photostability of pitavastatin--a novel HMG-CoA reductase inhibitor. | Journal of pharmaceutical and biomedical analysis 20091101 |
| Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity. | Journal of molecular and cellular cardiology 20091101 |
| Comparison of pitavastatin with simvastatin in primary hypercholesterolaemia or combined dyslipidaemia. | Current medical research and opinion 20091101 |
| Effects of pitavastatin on serum lipids and high sensitivity C-reactive protein in type 2 diabetic patients. | Journal of atherosclerosis and thrombosis 20091001 |
| Effects of pitavastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on cardio-ankle vascular index in type 2 diabetic patients. | Journal of atherosclerosis and thrombosis 20091001 |
| Effects of pitavastatin (LIVALO Tablet) on high density lipoprotein cholesterol (HDL-C) in hypercholesterolemia. | Journal of atherosclerosis and thrombosis 20091001 |
| Effects of pitavastatin on monocyte chemoattractant protein-1 in hyperlipidemic patients. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20090901 |
| Early effect of lipid-lowering therapy with pitavastatin on regression of coronary atherosclerotic plaque. Comparison with atorvastatin. | Circulation journal : official journal of the Japanese Circulation Society 20090801 |
| Effects of pitavastatin on fasting and postprandial endothelial function and blood rheology in patients with stable coronary artery disease. | Circulation journal : official journal of the Japanese Circulation Society 20090801 |
| Pitavastatin fails to lower serum lipid levels or inhibit gastric carcinogenesis in helicobacter pylori-infected rodent models. | Cancer prevention research (Philadelphia, Pa.) 20090801 |
| Pitavastatin improves plasma pentraxin 3 and arterial stiffness in atherosclerotic patients with hypercholesterolemia. | Journal of atherosclerosis and thrombosis 20090801 |
| Effect of intensive statin therapy on regression of coronary atherosclerosis in patients with acute coronary syndrome: a multicenter randomized trial evaluated by volumetric intravascular ultrasound using pitavastatin versus atorvastatin (JAPAN-ACS [Japan assessment of pitavastatin and atorvastatin in acute coronary syndrome] study). | Journal of the American College of Cardiology 20090721 |
| Therapeutic neovascularization by nanotechnology-mediated cell-selective delivery of pitavastatin into the vascular endothelium. | Arteriosclerosis, thrombosis, and vascular biology 20090601 |
| Influence of statins on glucose tolerance in patients with type 2 diabetes mellitus: subanalysis of the collaborative study on hypercholesterolemia drug intervention and their benefits for atherosclerosis prevention (CHIBA study). | Journal of atherosclerosis and thrombosis 20090601 |
| Stress-induced PAI-1 expression is suppressed by pitavastatin in vivo. | International journal of hematology 20090501 |
| Pitavastatin prevents intestinal ischemia/reperfusion-induced bacterial translocation and lung injury in atherosclerotic rats with hypoadiponectinemia. | Surgery 20090501 |
| Effects of statins on the pharmacokinetics of midazolam in healthy volunteers. | Journal of clinical pharmacology 20090501 |
| Pitavastatin suppresses mitogen activated protein kinase-mediated Erg-1 induction in human vascular smooth muscle cells. | European journal of pharmacology 20090315 |
| Induction of autophagic cell death and radiosensitization by the pharmacological inhibition of nuclear factor-kappa B activation in human glioma cell lines. | Journal of neurosurgery 20090301 |
| Effects of pitavastatin on cerebral blood flow. | Clinical therapeutics 20090301 |
| Pitavastatin induces PON1 expression through p44/42 mitogen-activated protein kinase signaling cascade in Huh7 cells. | Atherosclerosis 20090201 |
| Integrated backscatter and intima-media thickness of the thoracic aorta evaluated by transesophageal echocardiography in hypercholesterolemic patients: effect of pitavastatin therapy. | Ultrasound in medicine & biology 20090201 |
| Possible involvement of corticotropin-releasing factor receptor signaling on vascular inflammation. | Peptides 20090201 |
| Cardioprotective effects of pitavastatin on cardiac performance and remodeling in failing rat hearts. | American journal of hypertension 20090201 |
| Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors. | Circulation journal : official journal of the Japanese Circulation Society 20090201 |
| Treatment with statin on atheroma regression evaluated by intravascular ultrasound with Virtual Histology (TRUTH Study): rationale and design. | Circulation journal : official journal of the Japanese Circulation Society 20090201 |
| The effects of pitavastatin, eicosapentaenoic acid and combined therapy on platelet-derived microparticles and adiponectin in hyperlipidemic, diabetic patients. | Platelets 20090201 |
| Pitavastatin suppresses formation and progression of cerebral aneurysms through inhibition of the nuclear factor kappaB pathway. | Neurosurgery 20090201 |
| Pitavastatin attenuates leukocyte-endothelial interactions induced by ischemia-reperfusion injury in the rat retina. | Current eye research 20090101 |
| Estimation of pitavastatin calcium in tablet dosage forms by column liquid chromatography and ultraviolet spectrophotometry. | Journal of AOAC International 20090101 |
| Critical appraisal of the role of pitavastatin in treating dyslipidemias and achieving lipid goals. | Vascular health and risk management 20090101 |
| Multicenter collaborative randomized parallel group comparative study of pitavastatin and atorvastatin in Japanese hypercholesterolemic patients: collaborative study on hypercholesterolemia drug intervention and their benefits for atherosclerosis prevention (CHIBA study). | Atherosclerosis 20081201 |
| Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model. | Drug metabolism and disposition: the biological fate of chemicals 20081201 |
| Letter by Ntaios et al regarding article, 'impact of statin therapy on left ventricular function and carotid arterial stiffness in patients with hypercholesterolemia'. | Circulation journal : official journal of the Japanese Circulation Society 20081201 |
| Effects of pitavastatin on lipid profiles and high-sensitivity CRP in Japanese subjects with hypercholesterolemia: Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN) investigatars. | Journal of atherosclerosis and thrombosis 20081201 |
| Statin suppresses apoptosis in osteoblastic cells: role of transforming growth factor-beta-Smad3 pathway. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20081101 |
| Influence of pitavastatin on glucose tolerance in patients with type 2 diabetes mellitus. | Journal of atherosclerosis and thrombosis 20081001 |
| Comparative pharmacological study of free radical scavenger, nitric oxide synthase inhibitor, nitric oxide synthase activator and cyclooxygenase inhibitor against MPTP neurotoxicity in mice. | Metabolic brain disease 20080901 |
| Pitavastatin inhibits intimal hyperplasia in rabbit vein graft. | The Journal of surgical research 20080801 |
| Functional consequences of active hepatic uptake on cytochrome P450 inhibition in rat and human hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20080801 |
| Effects of different statins on endothelial nitric oxide synthase and AKT phosphorylation in endothelial cells. | International journal of cardiology 20080623 |
| Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression. | American journal of physiology. Heart and circulatory physiology 20080601 |
| Solid-phase extraction and liquid chromatography/tandem mass spectrometry assay for the determination of pitavastatin in human plasma and urine for application to Phase I clinical pharmacokinetic studies. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080601 |
| Effects of statin on small dense low-density lipoprotein cholesterol and remnant-like particle cholesterol in heterozygous familial hypercholesterolemia. | Journal of atherosclerosis and thrombosis 20080601 |
| A 52-week, randomized, open-label, parallel-group comparison of the tolerability and effects of pitavastatin and atorvastatin on high-density lipoprotein cholesterol levels and glucose metabolism in Japanese patients with elevated levels of low-density lipoprotein cholesterol and glucose intolerance. | Clinical therapeutics 20080601 |
| Combined effects of an 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor and angiotensin II receptor antagonist on nitric oxide bioavailability and atherosclerotic change in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits. | Hypertension research : official journal of the Japanese Society of Hypertension 20080601 |
| Comparison of effects of pitavastatin and atorvastatin on plasma coenzyme Q10 in heterozygous familial hypercholesterolemia: results from a crossover study. | Clinical pharmacology and therapeutics 20080501 |
| Involvement of multiple efflux transporters in hepatic disposition of fexofenadine. | Molecular pharmacology 20080501 |
| Effects of statins on adipose tissue inflammation: their inhibitory effect on MyD88-independent IRF3/IFN-beta pathway in macrophages. | Arteriosclerosis, thrombosis, and vascular biology 20080501 |
| Pitavastatin may reduce risk of steroid-induced osteonecrosis in rabbits: a preliminary histological study. | Clinical orthopaedics and related research 20080501 |
| The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. | Pharmacogenetics and genomics 20080501 |
| Effect of pitavastatin on type 2 diabetes mellitus nephropathy in KK-Ay/Ta mice. | Metabolism: clinical and experimental 20080501 |
| Association between risk of myopathy and cholesterol-lowering effect: a comparison of all statins. | Life sciences 20080423 |
| Development and validation of a liquid chromatography-tandem mass spectrometric assay for pitavastatin and its lactone in human plasma and urine. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080401 |
| Impact of statin therapy on left ventricular function and carotid arterial stiffness in patients with hypercholesterolemia. | Circulation journal : official journal of the Japanese Circulation Society 20080401 |
| Pitavastatin improves serum resistin levels in patients with hypercholesterolemia. | Journal of atherosclerosis and thrombosis 20080401 |
| Effects of rosuvastatin and pitavastatin on ischemia-induced myocardial stunning in dogs. | Journal of pharmacological sciences 20080401 |
| Rapid stabilization of vulnerable carotid plaque within 1 month of pitavastatin treatment in patients with acute coronary syndrome. | Journal of cardiovascular pharmacology 20080401 |
| Comparisons of short- and intermediate-term effects of pitavastatin versus atorvastatin on lipid profiles, fibrinolytic parameter, and endothelial function. | International journal of cardiology 20080328 |
| Modulation of celecoxib- and streptozotocin-induced experimental dementia of Alzheimer's disease by pitavastatin and donepezil. | Journal of psychopharmacology (Oxford, England) 20080301 |
| [Effect of pitavastatin on macrophage cholesterol metabolism]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080301 |
| Determination of two HMG-CoA reductase inhibitors, pravastatin and pitavastatin, in plasma samples using liquid chromatography-tandem mass spectrometry for pharmaceutical study. | Biomedical chromatography : BMC 20080201 |
| Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes. | Nitric oxide : biology and chemistry 20080201 |
| Pitavastatin decreases plasma prebeta1-HDL concentration and might promote its disappearance rate in hypercholesterolemic patients. | Journal of atherosclerosis and thrombosis 20080201 |
| HMG-CoA reductase inhibition improves anti-aging klotho protein expression and arteriosclerosis in rats with chronic inhibition of nitric oxide synthesis. | International journal of cardiology 20080111 |
| Pitavastatin, an HMG-CoA reductase inhibitor, exerts eNOS-independent protective actions against angiotensin II induced cardiovascular remodeling and renal insufficiency. | Circulation research 20080104 |
| Correlation between adiponectin and reduction of cell adhesion molecules after pitavastatin treatment in hyperlipidemic patients with type 2 diabetes mellitus. | Thrombosis research 20080101 |
| Beneficial effects of pitavastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on cardiac function in ischemic and nonischemic heart failure. | International heart journal 20080101 |
| Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats. | BMC pharmacology 20080101 |
| A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesis. | International journal of cancer 20071115 |
| SLCO1B1 (OATP1B1, an uptake transporter) and ABCG2 (BCRP, an efflux transporter) variant alleles and pharmacokinetics of pitavastatin in healthy volunteers. | Clinical pharmacology and therapeutics 20071101 |
| Impact of lipid-lowering therapy with pitavastatin, a new HMG-CoA reductase inhibitor, on regression of coronary atherosclerotic plaque. | Circulation journal : official journal of the Japanese Circulation Society 20071101 |
| Pitavastatin: protection against neuronal retinal damage induced by ischemia-reperfusion injury in rats. | Current eye research 20071101 |
| Comparison of the efficacy and tolerability of pitavastatin and atorvastatin: an 8-week, multicenter, randomized, open-label, dose-titration study in Korean patients with hypercholesterolemia. | Clinical therapeutics 20071101 |
| [Deadly drug interactions]. | Nihon rinsho. Japanese journal of clinical medicine 20071028 |
| Pitavastatin: efficacy and safety in intensive lipid lowering. | Expert opinion on pharmacotherapy 20071001 |
| Determination of pitavastatin from human plasma using high performance liquid chromatography with fluorescence detection. | Se pu = Chinese journal of chromatography 20070901 |
| Renal protective effects of pitavastatin on spontaneously hypercholesterolaemic Imai Rats. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070801 |
| Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice. | Kidney international 20070801 |
| Downregulation of survivin expression and elevation of caspase-3 activity involved in pitavastatin-induced HepG 2 cell apoptosis. | Oncology reports 20070801 |
| Anti-adipogenic action of pitavastatin occurs through the coordinate regulation of PPARgamma and Pref-1 expression. | British journal of pharmacology 20070701 |
| Effect of pitavastatin on experimental choroidal neovascularization in rats. | Experimental eye research 20070601 |
| Pitavastatin inactivates NF-kappaB and decreases IL-6 production through Rho kinase pathway in MCF-7 cells. | Oncology reports 20070501 |
| [Effects of NK-104 on apoptosis and caspase-3 activity in hepatocellular carcinoma cells]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20070501 |
| Pitavastatin suppresses acute and chronic rejection in murine cardiac allografts. | Transplantation 20070427 |
| Pitavastatin inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation. | Vascular pharmacology 20070401 |
| Postischemic alterations of BDNF, NGF, HSP 70 and ubiquitin immunoreactivity in the gerbil hippocampus: pharmacological approach. | Cellular and molecular neurobiology 20070301 |
| Immunohistochemical study on distribution of NF-kappaB and p53 in gerbil hippocampus after transient cerebral ischemia: effect of pitavastatin. | Metabolic brain disease 20070301 |
| Pitavastatin restores vascular dysfunction in insulin-resistant state by inhibiting NAD(P)H oxidase activity and uncoupled endothelial nitric oxide synthase-dependent superoxide production. | Journal of cardiovascular pharmacology 20070301 |
| Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. | British journal of pharmacology 20070201 |
| Pitavastatin prevents NMDA-induced retinal ganglion cell death by suppressing leukocyte recruitment. | Journal of neurochemistry 20070201 |
| Pitavastatin attenuates the upregulation of tissue factor in restraint-stressed mice. | Thrombosis research 20070101 |
| Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats. | Endocrinology 20070101 |
| CYP2C76-mediated species difference in drug metabolism: a comparison of pitavastatin metabolism between monkeys and humans. | Xenobiotica; the fate of foreign compounds in biological systems 20070101 |
| Determination of pitavastatin in human plasma via HPLC-ESI-MS/MS and subsequent application to a clinical study in healthy Chinese volunteers. | Clinica chimica acta; international journal of clinical chemistry 20070101 |
| Short-term effects of pitavastatin on biochemical markers of bone turnover in patients with hypercholesterolemia. | Internal medicine (Tokyo, Japan) 20070101 |
| Effects of pitavastatin on adiponectin in patients with hyperlipidemia. | Pathophysiology of haemostasis and thrombosis 20070101 |
| Japan assessment of pitavastatin and atorvastatin in acute coronary syndrome (JAPAN-ACS): rationale and design. | Circulation journal : official journal of the Japanese Circulation Society 20061201 |
| Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin: potential role of the RhoA-extracellular signal-regulated kinase-serum response factor signalling pathway. | Clinical and experimental pharmacology & physiology 20061201 |
| Comparative effects of pitavastatin and probucol on oxidative stress, Cu/Zn superoxide dismutase, PPAR-gamma, and aortic stiffness in hypercholesterolemia. | American journal of physiology. Heart and circulatory physiology 20061101 |
| Pitavastatin attenuates the PDGF-induced LR11/uPA receptor-mediated migration of smooth muscle cells. | Biochemical and biophysical research communications 20061006 |
| A therapeutic dose of the lipophilic statin pitavastatin enhances oxidant-induced apoptosis in human vascular smooth muscle cells. | Journal of cardiovascular pharmacology 20061001 |
| Pitavastatin-induced downregulation of CCR2 and CCR5 in monocytes is associated with the arrest of cell-cycle in S phase. | Atherosclerosis 20060801 |
| Drug-drug interaction between pitavastatin and various drugs via OATP1B1. | Drug metabolism and disposition: the biological fate of chemicals 20060701 |
| Dose-dependent effect of pitavastatin on VEGF and angiogenesis in a mouse model of choroidal neovascularization. | Investigative ophthalmology & visual science 20060601 |
| Differential effects of different statins on endothelin-1 gene expression and endothelial NOS phosphorylation in porcine aortic endothelial cells. | Experimental biology and medicine (Maywood, N.J.) 20060601 |
| Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. | Journal of cardiovascular pharmacology 20060601 |
| [The pro-angiogenesis effect of Pitavastatin in the Klotho gene-knockout mice]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20060501 |
| Pitavastatin effect on ATP binding cassette A1-mediated lipid efflux from macrophages: evidence for liver X receptor (LXR)-dependent and LXR-independent mechanisms of activation by cAMP. | The Journal of pharmacology and experimental therapeutics 20060401 |
| Anti-inflammatory effect of pitavastatin on NF-kappaB activated by TNF-alpha in hepatocellular carcinoma cells. | Biological & pharmaceutical bulletin 20060401 |
| Efficacy of a low dose of pitavastatin compared with atorvastatin in primary hyperlipidemia: results of a 12-week, open label study. | Journal of atherosclerosis and thrombosis 20060401 |
| The role of pitavastatin-enhanced lipoprotein lipase expression in 3T3-L1 preadipocytes. | Journal of atherosclerosis and thrombosis 20060401 |
| [Pitavastatin enhances angiogenesis and perfusion in a murine mode of limb ischemia]. | Zhonghua xin xue guan bing za zhi 20060301 |
| Endothelial urocortin has potent antioxidative properties and is upregulated by inflammatory cytokines and pitavastatin. | Journal of vascular research 20060101 |
| Statins and osteoporosis: new role for old drugs. | The Journal of pharmacy and pharmacology 20060101 |
| Effect of pitavastatin on urinary liver-type fatty-acid-binding protein in patients with nondiabetic mild chronic kidney disease. | American journal of nephrology 20060101 |
| Efficacy of pitavastatin, a new HMG-CoA reductase inhibitor, on lipid and glucose metabolism in patients with type 2 diabetes. | Diabetes care 20051201 |
| Biphasic effect of HMG-CoA reductase inhibitor, pitavastatin, on vascular endothelial cells and angiogenesis. | Circulation journal : official journal of the Japanese Circulation Society 20051201 |
| Alterations of interneurons of the gerbil hippocampus after transient cerebral ischemia: effect of pitavastatin. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20051101 |
| Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin. | British journal of clinical pharmacology 20051101 |
| Effect of pitavastatin on urinary liver-type fatty acid-binding protein levels in patients with early diabetic nephropathy. | Diabetes care 20051101 |
| Pitavastatin inhibits cardiac hypertrophy in a rat model of progressive renal injury. | Journal of cardiovascular pharmacology 20051001 |
| Effect of OATP1B1 (SLCO1B1) variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers. | Clinical pharmacology and therapeutics 20051001 |
| Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. | The Journal of pharmacy and pharmacology 20051001 |
| Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatin. | Molecular pharmacology 20050901 |
| Statin attenuates high glucose-induced and angiotensin II-induced MAP kinase activity through inhibition of NAD(P)H oxidase activity in cultured mesangial cells. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20050901 |
| Statin attenuates high glucose-induced and diabetes-induced oxidative stress in vitro and in vivo evaluated by electron spin resonance measurement. | Free radical biology & medicine 20050815 |
| Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. | The Journal of pharmacology and experimental therapeutics 20050801 |
| Enhanced oxidative stress in neutrophils from hyperlipidemic guinea pig. | Atherosclerosis 20050701 |
| A randomized, open-label study to evaluate the efficacy and safety of pitavastatin compared with simvastatin in Korean patients with hypercholesterolemia. | Clinical therapeutics 20050701 |
| Inhibitory effect of pitavastatin (NK-104) on the C-reactive-protein-induced interleukin-8 production in human aortic endothelial cells. | Clinical science (London, England : 1979) 20050601 |
| C-reactive protein and statins: IL-8 as a molecular link? | Clinical science (London, England : 1979) 20050601 |
| Pitavastatin at low dose activates endothelial nitric oxide synthase through PI3K-AKT pathway in endothelial cells. | Life sciences 20050325 |
| Reduction of cerebral infarction in stroke-prone spontaneously hypertensive rats by statins associated with amelioration of oxidative stress. | Stroke 20050301 |
| Pharmacokinetics of pitavastatin in subjects with Child-Pugh A and B cirrhosis. | British journal of clinical pharmacology 20050301 |
| Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism. | Arteriosclerosis, thrombosis, and vascular biology 20050201 |
| A literature search on pharmacokinetic drug interactions of statins and analysis of how such interactions are reflected in package inserts in Japan. | Journal of clinical pharmacy and therapeutics 20050201 |
| Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene. | Metabolism: clinical and experimental 20050201 |
| Pitavastatin. | International journal of clinical practice 20050201 |
| Analysis of the global RNA expression profiles of skeletal muscle cells treated with statins. | Journal of atherosclerosis and thrombosis 20050101 |
| Pitavastatin enhanced lipoprotein lipase expression in 3T3-L1 preadipocytes. | Journal of atherosclerosis and thrombosis 20050101 |
| Pitavastatin prevents bacterial translocation after nonpulsatile/low-pressure blood flow in early atherosclerotic rat: inhibition of small intestine inducible nitric oxide synthase. | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20050101 |
| Involvement of multiple transporters in the efflux of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors across the blood-brain barrier. | The Journal of pharmacology and experimental therapeutics 20041201 |
| Functional interplay between the macrophage scavenger receptor class B type I and pitavastatin (NK-104). | Circulation 20041130 |
| Effect of pitavastatin on apolipoprotein A-I production in HepG2 cell. | Biochemical and biophysical research communications 20041112 |
| HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells. | Cardiovascular research 20041101 |
| Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 alpha-hydroxylase gene expression in HepG2 cells. | Circulation journal : official journal of the Japanese Circulation Society 20041101 |
| Contribution of vascular NAD(P)H oxidase to endothelial dysfunction in heart failure and the therapeutic effects of HMG-CoA reductase inhibitor. | Circulation journal : official journal of the Japanese Circulation Society 20041101 |
| Optimal windows of statin use for immediate infarct limitation: 5'-nucleotidase as another downstream molecule of phosphatidylinositol 3-kinase. | Circulation 20041012 |
| Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. | The Journal of pharmacology and experimental therapeutics 20041001 |
| A new HMG-CoA reductase inhibitor, pitavastatin remarkably retards the progression of high cholesterol induced atherosclerosis in rabbits. | Atherosclerosis 20041001 |
| Statins as a possible distribution modulator of bone marrow-derived smooth muscle cells in plaques? | Atherosclerosis 20041001 |
| Protective effect of pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, on ischemia-induced neuronal damage. | Neurological research 20040901 |
| Effect of pitavastatin against expression of S100beta protein in the gerbil hippocampus after transient cerebral ischaemia. | Acta physiologica Scandinavica 20040901 |
| Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, reduces hippocampal damage after transient cerebral ischemia in gerbils. | Journal of neural transmission (Vienna, Austria : 1996) 20040901 |
| Pitavastatin increases ABCA1-mediated lipid efflux from Fu5AH rat hepatoma cells. | Biochemical and biophysical research communications 20040827 |
| Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. | Arteriosclerosis, thrombosis, and vascular biology 20040801 |
| MCP-1-induced enhancement of THP-1 adhesion to vascular endothelium was modulated by HMG-CoA reductase inhibitor through RhoA GTPase-, but not ERK1/2-dependent pathway. | Life sciences 20040730 |
| Inhibitory efficacy of pitavastatin on the early inflammatory response and neointimal thickening in a porcine coronary after stenting. | Atherosclerosis 20040601 |
| Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis. | Hypertension (Dallas, Tex. : 1979) 20040601 |
| Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, blocks vascular smooth muscle cell populated-collagen lattice contraction. | Journal of cardiovascular pharmacology 20040601 |
| Pitavastatin enhances the anti-fibrogenesis effects of candesartan, an angiotensin II receptor blocker, on CCl4-induced liver fibrosis in rats. | Journal of UOEH 20040601 |
| [Pharmacological and pharmacokinetic features and clinical effects of pitavastatin (Livalo Tablet)]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20040501 |
| Anti-lipid deposition effect of HMG-CoA reductase inhibitor, pitavastatin, in a rat model of hypertension and hypercholesterolemia. | Life sciences 20040312 |
| The novel HMG-CoA reductase inhibitor, Pitavastatin, induces a protective action in vascular endothelial cells through the production of nitric oxide (NO). | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040301 |
| Pitavastatin downregulates expression of the macrophage type B scavenger receptor, CD36. | Circulation 20040217 |
| Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. | Biochemical and biophysical research communications 20040206 |
| High glucose-induced upregulation of osteopontin is mediated via Rho/Rho kinase pathway in cultured rat aortic smooth muscle cells. | Arteriosclerosis, thrombosis, and vascular biology 20040201 |
| Effect of gemfibrozil on the metabolism of pitavastatin--determining the best animal model for human CYP and UGT activities. | Drug metabolism and drug interactions 20040101 |
| Metabolic stability and uptake by human hepatocytes of pitavastatin, a new inhibitor of HMG-CoA reductase. | Arzneimittel-Forschung 20040101 |
| Pitavastatin alters the expression of thrombotic and fibrinolytic proteins in human vascular cells. | Journal of cellular biochemistry 20030901 |
| Pitavastatin inhibits upregulation of intermediate conductance calcium-activated potassium channels and coronary arteriolar remodeling induced by long-term blockade of nitric oxide synthesis. | Pharmacology 20030801 |
| Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: similarities and difference in the metabolism of pitavastatin in monkeys and humans. | Xenobiotica; the fate of foreign compounds in biological systems 20030701 |
| Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice. | Lipids 20030501 |
| Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family. | Arteriosclerosis, thrombosis, and vascular biology 20030301 |
| Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization. | Xenobiotica; the fate of foreign compounds in biological systems 20030101 |
| Pitavastatin inhibits vascular smooth muscle cell proliferation by inactivating extracellular signal-regulated kinases 1/2. | Journal of atherosclerosis and thrombosis 20030101 |
| Interaction between several medicines and statins. | Arzneimittel-Forschung 20030101 |
| Triglyceride-lowering effect of pitavastatin in a guinea pig model of postprandial lipemia. | Arzneimittel-Forschung 20030101 |
| Plaque-stabilizing effect of pitavastatin in Watanabe heritable hyperlipidemic (WHHL) rabbits. | Journal of atherosclerosis and thrombosis 20030101 |
| Effect of pitavastatin on sterol and bile acid excretion in guinea pigs. | Arzneimittel-Forschung 20030101 |
| Pitavastatin: efficacy and safety profiles of a novel synthetic HMG-CoA reductase inhibitor. | Cardiovascular drug reviews 20030101 |
| Interaction between fibrates and statins--metabolic interactions with gemfibrozil. | Drug metabolism and drug interactions 20030101 |
| Pitavastatin Nissan/Kowa Yakuhin/Novartis/Sankyo. | Current opinion in investigational drugs (London, England : 2000) 20020901 |
| Pharmacology of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins), including rosuvastatin and pitavastatin. | Journal of clinical pharmacology 20020801 |
| Long-term treatment with pitavastatin (NK-104), a new HMG-CoA reductase inhibitor, of patients with heterozygous familial hypercholesterolemia. | Atherosclerosis 20020701 |
| A randomized, double-blind trial comparing the efficacy and safety of pitavastatin versus pravastatin in patients with primary hypercholesterolemia. | Atherosclerosis 20020601 |
| Triglyceride-lowering effect of pitavastatin [corrected] in a rat model of postprandial lipemia. | European journal of pharmacology 20020524 |
| Novel statins: pharmacological and clinical results. | Cardiovascular drugs and therapy 20020501 |
| Inhibition of migration and proliferation of rat vascular smooth muscle cells by a new HMG-CoA reductase inhibitor, pitavastatin. | Hypertension research : official journal of the Japanese Society of Hypertension 20020301 |
| Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB. | Biochemical and biophysical research communications 20020111 |
| Pitavastatin. Itavastatin, Nisvastatin, Nk 104, Nks 104, P 872441. | Drugs in R&D 20020101 |
| Clinical efficacy of pitavastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in patients with hyperlipidemia. Dose-finding study using the double-blind, three-group parallel comparison. | Arzneimittel-Forschung 20020101 |
| The effect of statins on mRNA levels of genes related to inflammation, coagulation, and vascular constriction in HUVEC. Human umbilical vein endothelial cells. | Journal of atherosclerosis and thrombosis 20020101 |
| Metabolic fate of pitavastatin (NK-104), a new inhibitor of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase. Effects on drug-metabolizing systems in rats and humans. | Arzneimittel-Forschung 20020101 |
| [Lipid-lowering drugs]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20011201 |
| Synthesis and biological evaluations of quinoline-based HMG-CoA reductase inhibitors. | Bioorganic & medicinal chemistry 20011001 |
| Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. | Biochemical and biophysical research communications 20010921 |
| Simultaneous determination of taxol and its metabolites in microsomal samples by a simple thin-layer chromatography radioactivity assay--inhibitory effect of NK-104, a new inhibitor of HMG-CoA reductase. | Journal of chromatography. B, Biomedical sciences and applications 20010605 |
| Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I. | The Journal of clinical investigation 20010601 |
| NK-104, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells. | British journal of pharmacology 20010501 |
| [New statins under clinical development: nisvastatin and rosuvastatin]. | Nihon rinsho. Japanese journal of clinical medicine 20010301 |
| Hypolipidemic effect of NK-104 and other 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in guinea pigs. | Arzneimittel-Forschung 20010101 |
| Cholesterol-lowering effect of NK-104, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, in guinea pig model of hyperlipidemia. | Arzneimittel-Forschung 20010101 |
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