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147059-75-4 | 1,8-Naphthyridine-3-carboxylic acid, 7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, methanesulfonate (1:1)
CAS No: 147059-75-4 Catalog No: AG001EKX MDL No:MFCD00913361
Product Description
Catalog Number:
AG001EKX
Chemical Name:
1,8-Naphthyridine-3-carboxylic acid, 7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, methanesulfonate (1:1)
CAS Number:
147059-75-4
Molecular Formula:
C20H15F3N4O3
Molecular Weight:
416.3533
MDL Number:
MFCD00913361
IUPAC Name:
7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid;methanesulfonic acid
InChI:
InChI=1S/C20H15F3N4O3.CH4O3S/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24;1-5(2,3)4/h1-4,7,10-11,16H,5-6,24H2,(H,29,30);1H3,(H,2,3,4)/t10-,11+,16?;
InChI Key:
DYNZICQDCVYXFW-GIPYJWDTSA-N
SMILES:
NC1[C@@H]2[C@H]1CN(C2)c1nc2c(cc1F)c(=O)c(cn2c1ccc(cc1F)F)C(=O)O
UNII:
0P1LKO80WN
Properties
Complexity:
863
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
0
Exact Mass:
512.098g/mol
Formal Charge:
0
Heavy Atom Count:
35
Hydrogen Bond Acceptor Count:
13
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
512.46g/mol
Monoisotopic Mass:
512.098g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
163A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Post-approval translational research itself has diverse ethics. | The American journal of bioethics : AJOB 20100801 |
| Ethical problems in conducting research in acute epidemics: the Pfizer meningitis study in Nigeria as an illustration. | Developing world bioethics 20100401 |
| Understanding informed consent for participation in international health research. | Developing world bioethics 20090801 |
| Globalized clinical trials and informed consent. | The New England journal of medicine 20090514 |
| Drug company trials come under increasing scrutiny. | Lancet (London, England) 20080119 |
| Pfizer lawsuit spotlights ethics of developing world clinical trials. | Nature medicine 20070701 |
| Secret report surfaces showing that Pfizer was at fault in Nigerian drug tests. | BMJ (Clinical research ed.) 20060527 |
| Sequential IV/PO moxifloxacin treatment of patients with severe community-acquired pneumonia. | Respiratory medicine 20031001 |
| Effects of alatrofloxacin, the parental prodrug of trovafloxacin, on phagocytic, anti-inflammatory and immunomodulation events of human THP-1 monocytes. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20031001 |
| Nigerians in drug trial take their case to US court. | BMJ (Clinical research ed.) 20030426 |
| Pfizer in 'unethical' trial suit. | Nature medicine 20011001 |
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