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1464-53-5 | 2,2'-Bioxirane
CAS No: 1464-53-5 Catalog No: AG001DZ2 MDL No:MFCD00005120
Product Description
Catalog Number:
AG001DZ2
Chemical Name:
2,2'-Bioxirane
CAS Number:
1464-53-5
Molecular Formula:
C4H6O2
Molecular Weight:
86.0892
MDL Number:
MFCD00005120
IUPAC Name:
2-(oxiran-2-yl)oxirane
InChI:
InChI=1S/C4H6O2/c1-3(5-1)4-2-6-4/h3-4H,1-2H2
InChI Key:
ZFIVKAOQEXOYFY-UHFFFAOYSA-N
SMILES:
O1CC1C1OC1
NSC Number:
629
Properties
Complexity:
61.9
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
86.037g/mol
Formal Charge:
0
Heavy Atom Count:
6
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
86.09g/mol
Monoisotopic Mass:
86.037g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
25.1A^2
Undefined Atom Stereocenter Count:
2
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.5
Literature
| Title | Journal |
|---|---|
| Cross-linking by epichlorohydrin and diepoxybutane correlates with cytotoxicity and leads to apoptosis in human leukemia (HL-60) cells. | Toxicology and applied pharmacology 20180801 |
| Polymerase Bypass of N(6)-Deoxyadenosine Adducts Derived from Epoxide Metabolites of 1,3-Butadiene. | Chemical research in toxicology 20150720 |
| Induction of DNA damage and G2 cell cycle arrest by diepoxybutane through the activation of the Chk1-dependent pathway in mouse germ cells. | Chemical research in toxicology 20150316 |
| Arsenic exposure disrupts the normal function of the FA/BRCA repair pathway. | Toxicological sciences : an official journal of the Society of Toxicology 20141101 |
| In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice. | Chemical research in toxicology 20131118 |
| DNA damage induced by three major metabolites of 1,3-butadiene in human hepatocyte L02 cells. | Mutation research 20120918 |
| Genotoxicity of alkene epoxides in human peripheral blood mononuclear cells and HL60 leukaemia cells evaluated with the comet assay. | Mutation research 20120830 |
| FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. | Nature genetics 20120801 |
| Mutation spectra of S-(2-hydroxy-3,4-epoxybutyl)glutathione: comparison with 1,3-butadiene and its metabolites in the Escherichia coli rpoB gene. | Chemical research in toxicology 20120716 |
| Analysis of in vitro chemoprevention of genotoxic damage by phytochemicals, as single agents or as combinations. | Mutation research 20120515 |
| Conjugation of butadiene diepoxide with glutathione yields DNA adducts in vitro and in vivo. | Chemical research in toxicology 20120319 |
| Diepoxybutane interstrand cross-links induce DNA bending. | Biochimie 20120201 |
| Fanconi anemia and vaginal squamous cell carcinoma. | Rare tumors 20120102 |
| Formation of 1,2:3,4-diepoxybutane-specific hemoglobin adducts in 1,3-butadiene exposed workers. | Toxicological sciences : an official journal of the Society of Toxicology 20120101 |
| Assessment of DNA interstrand crosslinks using the modified alkaline comet assay. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Nijmegen breakage syndrome (NBS). | Orphanet journal of rare diseases 20120101 |
| Improvement of genetic stability in lymphocytes from Fanconi anemia patients through the combined effect of α-lipoic acid and N-acetylcysteine. | Orphanet journal of rare diseases 20120101 |
| Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic Strategies. | Anemia 20120101 |
| Chromosomal aberrations associated with clonal evolution and leukemic transformation in fanconi anemia: clinical and biological implications. | Anemia 20120101 |
| Diagnosis of fanconi anemia: chromosomal breakage analysis. | Anemia 20120101 |
| A Dutch Fanconi Anemia FANCC Founder Mutation in Canadian Manitoba Mennonites. | Anemia 20120101 |
| 1,2:3,4-Diepoxybutane in blood of male B6C3F1 mice and male Sprague-Dawley rats exposed to 1,3-butadiene. | Toxicology letters 20111215 |
| A mechanistic modeling framework for predicting metabolic interactions in complex mixtures. | Environmental health perspectives 20111201 |
| Diepoxybutane induces the formation of DNA-DNA rather than DNA-protein cross-links, and single-strand breaks and alkali-labile sites in human hepatocyte L02 cells. | Mutation research 20111101 |
| Protective effect of acetyl-l-carnitine and α-lipoic acid against the acute toxicity of diepoxybutane to human lymphocytes. | Toxicology 20111028 |
| Kinetics of ethylene and ethylene oxide in subcellular fractions of lungs and livers of male B6C3F1 mice and male fischer 344 rats and of human livers. | Toxicological sciences : an official journal of the Society of Toxicology 20111001 |
| Fanconi anemia-like presentation in an infant with constitutional deletion of 21q including the RUNX1 gene. | American journal of medical genetics. Part A 20110701 |
| 1,3-Butadiene: Biomarkers and application to risk assessment. | Chemico-biological interactions 20110630 |
| Fanconi anemia - learning from children. | Pediatric reports 20110622 |
| Persistence and repair of bifunctional DNA adducts in tissues of laboratory animals exposed to 1,3-butadiene by inhalation. | Chemical research in toxicology 20110620 |
| Dyskeratosis congenita and the DNA damage response. | British journal of haematology 20110601 |
| Incidence of Fanconi anemia in children with congenital thumb anomalies referred for diepoxybutane testing. | The Journal of hand surgery 20110601 |
| Genotoxicity of stereoisomers of 1,2,3,4-diepoxybutane in the gpt gene of Chinese hamster ovary AS52 cells. | Bulletin of environmental contamination and toxicology 20110601 |
| Chromosome fragility in patients with Fanconi anaemia: diagnostic implications and clinical impact. | Journal of medical genetics 20110401 |
| Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish. | PLoS genetics 20110301 |
| Cholestasis in patients with Cockayne syndrome and suggested modified criteria for clinical diagnosis. | Orphanet journal of rare diseases 20110101 |
| HPLC-UV, MALDI-TOF-MS and ESI-MS/MS analysis of the mechlorethamine DNA crosslink at a cytosine-cytosine mismatch pair. | PloS one 20110101 |
| sunTILL: a TILLING resource for gene function analysis in sunflower. | Plant methods 20110101 |
| Diepoxybutane. | Report on carcinogens : carcinogen profiles 20110101 |
| Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: a cross sectional study. | Environmental health : a global access science source 20110101 |
| [Fanconi anemia: cytogenetic diagnosis of 40 cases]. | Acta medica portuguesa 20110101 |
| Cytoprotective effect of honey against chromosomal breakage in fanconi anemia patients in vitro. | Indian journal of human genetics 20110101 |
| Evaluation of concentration and storage effects of mitomycin C in the diagnosis of Fanconi anemia among idiopatic aplastic anemia patients. | Indian journal of human genetics 20110101 |
| The first syntheses of enantiopure 2,2'-biindoline. | Chemical communications (Cambridge, England) 20101228 |
| Olfactory receptor cells respond to odors in a tissue and semiconductor hybrid neuron chip. | Biosensors & bioelectronics 20101215 |
| Hemoglobin adducts in 1,3-butadiene exposed Czech workers: female-male comparisons. | Chemico-biological interactions 20101205 |
| RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer. | Carcinogenesis 20101201 |
| Normal red blood cells partially decrease diepoxybutane-induced chromosome breakage in cultured lymphocytes from Fanconi anaemia patients. | Cell proliferation 20101201 |
| A child with myelodysplastic syndrome with hypocellular fibrosis. | Journal of pediatric hematology/oncology 20101101 |
| Chromosomal breakage study in children suspected with Fanconi anemia in the Indian population. | Journal of pediatric hematology/oncology 20101101 |
| DNA oligomers containing site-specific and stereospecific exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, characterization, and effects on DNA structure. | Chemical research in toxicology 20101018 |
| Mutagenicity of a glutathione conjugate of butadiene diepoxide. | Chemical research in toxicology 20101018 |
| Evaluation of molecularly imprinted solid-phase extraction for a 1,2:3,4-diepoxybutane adduct to valine. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101001 |
| 1,3-Butadiene: I. Review of metabolism and the implications to human health risk assessment. | Critical reviews in toxicology 20101001 |
| 1,3-Butadiene: II. Genotoxicity profile. | Critical reviews in toxicology 20101001 |
| Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor. | PLoS pathogens 20101001 |
| DNA-protein cross-linking by 1,2,3,4-diepoxybutane. | Journal of proteome research 20100903 |
| Exposure-response of 1,2:3,4-diepoxybutane-specific N-terminal valine adducts in mice and rats after inhalation exposure to 1,3-butadiene. | Toxicological sciences : an official journal of the Society of Toxicology 20100601 |
| Mutagenicity of stereochemical configurations of 1,3-butadiene epoxy metabolites in human cells. | Research report (Health Effects Institute) 20100601 |
| Long-term evaluation of chromosomal breakages after radioisotope synovectomy for treatment of target joints in patients with haemophilia. | Haemophilia : the official journal of the World Federation of Hemophilia 20100501 |
| Fanconi anemia is characterized by delayed repair kinetics of DNA double-strand breaks. | The Tohoku journal of experimental medicine 20100501 |
| Column switching HPLC-ESI(+)-MS/MS methods for quantitative analysis of exocyclic dA adducts in the DNA of laboratory animals exposed to 1,3-butadiene. | Chemical research in toxicology 20100419 |
| Quantitative investigation on the metabolism of 1,3-butadiene and of its oxidized metabolites in once-through perfused livers of mice and rats. | Toxicological sciences : an official journal of the Society of Toxicology 20100301 |
| Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells. | Mutation research 20100203 |
| Clinical, genetic and cytogenetic study of Fanconi anemia in an Indian population. | Hematology (Amsterdam, Netherlands) 20100201 |
| Late-onset Fanconi anemia in an African-Caribbean patient. | Journal of the National Medical Association 20100201 |
| Exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, structural elucidation, and mechanistic studies. | Chemical research in toxicology 20100118 |
| Rothmund-Thomson syndrome. | Orphanet journal of rare diseases 20100101 |
| Natural and artificial mutants as valuable resources for functional genomics and molecular breeding. | International journal of biological sciences 20100101 |
| Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms. | Breast cancer research : BCR 20100101 |
| Genetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicology. | Human genomics and proteomics : HGP 20100101 |
| Incidence of malignancy and clonal chromosomal abnormalities in Fanconi anemia. | Indian journal of cancer 20100101 |
| Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells. | PloS one 20100101 |
| Diagnostic Overlap between Fanconi Anemia and the Cohesinopathies: Roberts Syndrome and Warsaw Breakage Syndrome. | Anemia 20100101 |
| Kinetics of the reactions of isoprene-derived epoxides in model tropospheric aerosol solutions. | Environmental science & technology 20091101 |
| Cob(I)alamin for trapping butadiene epoxides in metabolism with rat S9 and for determining associated kinetic parameters. | Chemical research in toxicology 20090901 |
| Genotoxicity of 1,3-butadiene and its epoxy intermediates. | Research report (Health Effects Institute) 20090801 |
| The Fanconi anemia protein interaction network: casting a wide net. | Mutation research 20090731 |
| Fanconi anemia and its diagnosis. | Mutation research 20090731 |
| Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins. | Environmental and molecular mutagenesis 20090701 |
| The bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced mutagenesis in recombinant systems. | Chemical research in toxicology 20090601 |
| [Pathogenesis of Fanconi anemia: FA-BRCA network -- review]. | Zhongguo shi yan xue ye xue za zhi 20090601 |
| Synthesis of fused-ring and attached-ring bis-tetrahydrofurans via Pd-catalyzed carboetherification. | Organic letters 20090521 |
| Quantitative PCR analysis of diepoxybutane and epihalohydrin damage to nuclear versus mitochondrial DNA. | Mutation research 20090512 |
| Investigation on the mechanisms of genotoxicity of butadiene, styrene and their combination in human lymphocytes using the Comet assay. | Mutation research 20090512 |
| PAH-DNA adducts, cigarette smoking, GST polymorphisms, and breast cancer risk. | Environmental health perspectives 20090401 |
| Molecular dosimetry of 1,2,3,4-diepoxybutane-induced DNA-DNA cross-links in B6C3F1 mice and F344 rats exposed to 1,3-butadiene by inhalation. | Cancer research 20090315 |
| FANCD2 Western blot as a diagnostic tool for Brazilian patients with Fanconi anemia. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20090301 |
| Increased capacity of lymphocytes from hereditary hemochromatosis patients homozygous for the C282Y HFE mutation to respond to the genotoxic effect of diepoxybutane. | Mutation research 20090219 |
| Liposome-based homogeneous luminescence resonance energy transfer. | Analytical biochemistry 20090115 |
| Detection of genomic deletions in rice using oligonucleotide microarrays. | BMC genomics 20090101 |
| Mechanism of diepoxybutane-induced p53 regulation in human cells. | Journal of biochemical and molecular toxicology 20090101 |
| The synthesis of 1-(4-triethoxysilyl)phenyl)-4,4,4-trifluoro-1,3-butanedione, a novel trialkoxysilane monomer for the preparation of functionalized sol-gel matrix materials. | Molecules (Basel, Switzerland) 20081020 |
| Vein patterning screens and the defectively organized tributaries mutants in Arabidopsis thaliana. | The Plant journal : for cell and molecular biology 20081001 |
| Evaluation of cancer tests of 1,3-butadiene using internal dose, genotoxic potency, and a multiplicative risk model. | Cancer research 20081001 |
| Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide. | Chemical research in toxicology 20080901 |
| A systematic review of meta-analyses on gene polymorphisms and gastric cancer risk. | Current genomics 20080901 |
| Correlation of thyroid and growth hormones to chromosomal instability in Egyptian Fanconi anemia patients. | Indian journal of pediatrics 20080701 |
| Rice lesion mimic mutants with enhanced resistance to diseases. | Molecular genetics and genomics : MGG 20080601 |
| Cigarette smoke induces genetic instability in airway epithelial cells by suppressing FANCD2 expression. | British journal of cancer 20080520 |
| Quantitative high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry analysis of the adenine-guanine cross-links of 1,2,3,4-diepoxybutane in tissues of butadiene-exposed B6C3F1 mice. | Chemical research in toxicology 20080501 |
| DNA repair decline during mouse spermiogenesis results in the accumulation of heritable DNA damage. | DNA repair 20080402 |
| Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations. | Chemical research in toxicology 20080201 |
| HPRT mutations in lymphocytes from 1,3-butadiene-exposed workers in China. | Environmental health perspectives 20080201 |
| Biomarkers and mechanisms of FANCD2 function. | Journal of biomedicine & biotechnology 20080101 |
| Flow cytometry for diepoxybutane test analysis. | Genetics and molecular research : GMR 20080101 |
| Diepoxybutane activates the mitochondrial apoptotic pathway and mediates apoptosis in human lymphoblasts through oxidative stress. | Toxicology in vitro : an international journal published in association with BIBRA 20071201 |
| Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. | PLoS genetics 20071201 |
| [Gene regulation to lactic acid bacteria for increasing production of flavor metabolite]. | Wei sheng wu xue bao = Acta microbiologica Sinica 20071201 |
| Preparation of DL-2,3,4-trihydroxybutylarsonic acid and dl-2,3-dihydroxybutane-1,4-bis(arsonic acid): starting compounds for novel arsonolipids. | Chemistry and physics of lipids 20070801 |
| Positive diepoxybutane test in a patient with Nijmegen breakage syndrome. | Pediatric blood & cancer 20070701 |
| Loss of FANCC function is associated with failure to inhibit late firing replication origins after DNA cross-linking. | Experimental cell research 20070701 |
| A ketone oximate based cyclic cationic [Ni(II)4] inverse metallacrown from simultaneous chelation and bridging of two ligands. | Dalton transactions (Cambridge, England : 2003) 20070528 |
| Development of a physiologically based toxicokinetic model for butadiene and four major metabolites in humans: global sensitivity analysis for experimental design issues. | Chemico-biological interactions 20070501 |
| Mutagenesis of the supF gene by stereoisomers of 1,2,3,4-diepoxybutane. | Chemical research in toxicology 20070501 |
| HPLC-ESI+-MS/MS analysis of N7-guanine-N7-guanine DNA cross-links in tissues of mice exposed to 1,3-butadiene. | Chemical research in toxicology 20070501 |
| In vitro effect of fludarabine, cyclophosphamide, and cytosine arabinoside on chromosome breakage in Fanconi anemia patients: relevance to stem cell transplantation. | International journal of hematology 20070501 |
| A comprehensive strategy for the subtyping of patients with Fanconi anaemia: conclusions from the Spanish Fanconi Anemia Research Network. | Journal of medical genetics 20070401 |
| Site specific N6-(2-hydroxy-3,4-epoxybut-1-yl)adenine oligodeoxynucleotide adducts of 1,2,3,4-diepoxybutane: synthesis and stability at physiological pH. | Chemical research in toxicology 20070401 |
| Metabolism of 1,3-butadiene to toxicologically relevant metabolites in single-exposed mice and rats. | Chemico-biological interactions 20070320 |
| Some insights into the mode of action of butadiene by examining the genotoxicity of its metabolites. | Chemico-biological interactions 20070320 |
| Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene. | Chemico-biological interactions 20070320 |
| Mutagenicity of stereochemical configurations of 1,2-epoxybutene and 1,2:3,4-diepoxybutane in human lymphblastoid cells. | Chemico-biological interactions 20070320 |
| Molecular epidemiological studies in 1,3-butadiene exposed Czech workers: female-male comparisons. | Chemico-biological interactions 20070320 |
| Structure of the 1,4-Bis(2'-deoxyadenosin-N(6)-yl)-2S,3S-butanediol intrastrand DNA cross-link arising from butadiene diepoxide in the human N-ras codon 61 sequence. | Chemical research in toxicology 20070201 |
| Structural elucidation of a novel DNA-DNA cross-link of 1,2,3,4-diepoxybutane. | Chemical research in toxicology 20070201 |
| A cross-sectional study of self-reported chemical-related sensitivity is associated with gene variants of drug-metabolizing enzymes. | Environmental health : a global access science source 20070101 |
| Use of the arginine-specific butanedione/phenylboronic acid tag for analysis of peptides and protein digests using matrix-assisted laser desorption/ionization mass spectrometry. | Rapid communications in mass spectrometry : RCM 20070101 |
| Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population. | BMC cancer 20070101 |
| The Fanconi anemia pathway and ubiquitin. | BMC biochemistry 20070101 |
| Cytogenetic sensitivity of G0 lymphocytes of Fanconi anemia patients and obligate carriers to mitomycin C and ionizing radiation. | Cytogenetic and genome research 20070101 |
| Influence of polymorphisms in xenobiotic-metabolizing genes and DNA-repair genes on diepoxybutane-induced SCE frequency. | Environmental and molecular mutagenesis 20061201 |
| Multiple endocrine neoplasia type 1 (MEN1) as a cancer predisposition syndrome: clues into the mechanisms of MEN1-related carcinogenesis. | The Yale journal of biology and medicine 20061201 |
| Fanconi anaemia complementation group B presenting as X linked VACTERL with hydrocephalus syndrome. | Journal of medical genetics 20060901 |
| Correlation of apoptotic potential of simple oxiranes with cytotoxicity. | Toxicology in vitro : an international journal published in association with BIBRA 20060801 |
| Multiple constitutional aetiological factors in bone marrow failure syndrome (BMFS) patients from north India. | The Indian journal of medical research 20060701 |
| Cobalamin as an analytical tool for analysis of oxirane metabolites of 1,3-butadiene: development and validation of the method. | Journal of chromatography. A 20060630 |
| Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane. | Chemical research in toxicology 20060501 |
| The atmospheric pressure Meerwein reaction. | Journal of mass spectrometry : JMS 20060401 |
| The role of foetal red blood cells in protecting cultured lymphocytes against diepoxybutane-induced chromosome breaks. | Mutation research 20060131 |
| The 5'-GNC site for DNA interstrand cross-linking is conserved for diepoxybutane stereoisomers. | Chemical research in toxicology 20060101 |
| Fanconi anemia manifesting as a squamous cell carcinoma of the hard palate: a case report. | Head & face medicine 20060101 |
| Epigenetic silencing and deletion of the BRCA1 gene in sporadic breast cancer. | Breast cancer research : BCR 20060101 |
| Fanconi anemia: causes and consequences of genetic instability. | Genome dynamics 20060101 |
| Evidence for Escherichia coli polymerase II mutagenic bypass of intrastrand DNA crosslinks. | DNA repair 20051208 |
| Interstrand and intrastrand DNA-DNA cross-linking by 1,2,3,4-diepoxybutane: role of stereochemistry. | Journal of the American Chemical Society 20051019 |
| GST genotype may modify clinical phenotype in patients with Fanconi anaemia. | British journal of haematology 20051001 |
| Quantification of DNA and hemoglobin adducts of 3,4-epoxy-1,2-butanediol in rodents exposed to 3-butene-1,2-diol. | Carcinogenesis 20050901 |
| Chemical- and irradiation-induced mutants of indica rice IR64 for forward and reverse genetics. | Plant molecular biology 20050901 |
| Genotoxicity sensor response correlated with DNA nucleobase damage rates measured by LC-MS. | Molecular bioSystems 20050901 |
| Structure of the 1,4-bis(2'-deoxyadenosin-N6-yl)-2R,3R-butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide. | Biochemistry 20050802 |
| Hemoglobin adducts and micronuclei in rodents after treatment with isoprene monoxide or butadiene monoxide. | Mutation research 20050801 |
| Reaction of 1,2,3,4-diepoxybutane with 2'-deoxyguanosine: initial products and their stabilities and decomposition patterns under physiological conditions. | Chemical research in toxicology 20050801 |
| Acute exposure of human lung cells to 1,3-butadiene diepoxide results in G1 and G2 cell cycle arrest. | Environmental and molecular mutagenesis 20050501 |
| Frequency of Fanconi anemia in Brazil and efficacy of screening for the FANCA 3788-3790del mutation. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20050501 |
| New insights into the Fanconi anemia pathway from an isogenic FancG hamster CHO mutant. | DNA repair 20050102 |
| Fanconi anemia: current management. | Hematology (Amsterdam, Netherlands) 20050101 |
| Analysis of diepoxide-specific cyclic N-terminal globin adducts in mice and rats after inhalation exposure to 1,3-butadiene. | Cancer research 20041201 |
| Guanine-adenine DNA cross-linking by 1,2,3,4-diepoxybutane: potential basis for biological activity. | Chemical research in toxicology 20041201 |
| Flanking sequences modulate diepoxide and mustard cross-linking efficiencies at the 5'-GNC site. | Chemical research in toxicology 20040801 |
| Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase. | Chemical research in toxicology 20040701 |
| DNA adducts in rats and mice following exposure to [4-14C]-1,2-epoxy-3-butene and to [2,3-14C]-1,3-butadiene. | Chemico-biological interactions 20040630 |
| Vulvar cancer in a patient with Fanconi's anemia, treated with 3D conformal radiotherapy. | American journal of hematology 20040601 |
| Hemoglobin adduct levels in rat and mouse treated with 1,2:3,4-diepoxybutane. | Chemical research in toxicology 20040601 |
| DNA interstrand cross-linking by a mycotoxic diepoxide. | Biochimie 20040601 |
| Characterization of alkyl-cobalamins formed on trapping of epoxide metabolites of 1,3-butadiene. | Journal of separation science 20040501 |
| Characterization of the reaction products of 2'-deoxyguanosine and 1,2,3,4-diepoxybutane after acid hydrolysis: formation of novel guanine and pyrimidine adducts. | Chemical research in toxicology 20040401 |
| [Progress of research on protein composition and gene therapy of Fanconi anaemia - review]. | Zhongguo shi yan xue ye xue za zhi 20040401 |
| Influence of GSTT1, mEH, CYP2E1 and RAD51 polymorphisms on diepoxybutane-induced SCE frequency in cultured human lymphocytes. | Mutation research 20040314 |
| Diepoxybutane induces caspase and p53-mediated apoptosis in human lymphoblasts. | Toxicology and applied pharmacology 20040301 |
| Alpha-mercaptoketone formation during the maillard reaction of cysteine and [1-(13)C]ribose. | Journal of agricultural and food chemistry 20040225 |
| Isolation and characterization of rice mutants compromised in Xa21-mediated resistance to X. oryzae pv. oryzae. | TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 20040201 |
| Structural characterization of the major DNA-DNA cross-link of 1,2,3,4-diepoxybutane. | Chemical research in toxicology 20040201 |
| Multiple endocrine neoplasia type 1 with unusual concomitance of various neoplastic disorders. | Endocrine journal 20040201 |
| DEB test for Fanconi anemia detection in patients with atypical phenotypes. | American journal of medical genetics. Part A 20040101 |
| Diepoxybutane. | Report on carcinogens : carcinogen profiles 20040101 |
| A definitive synthesis of D-myo-inositol 1,4,5,6-tetrakisphosphate and its enantiomer D-myo-inositol 3,4,5,6-tetrakisphosphate from a novel butane-2,3-diacetal-protected inositol. | Chemistry (Weinheim an der Bergstrasse, Germany) 20031215 |
| Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. | Developmental cell 20031201 |
| Identification and characterization of a series of nucleoside adducts formed by the reaction of 2'-deoxyguanosine and 1,2,3,4-diepoxybutane under physiological conditions. | Chemical research in toxicology 20031201 |
| Oxidative stress-related mechanisms are associated with xenobiotics exerting excess toxicity to Fanconi anemia cells. | Environmental health perspectives 20031101 |
| Genetic susceptibility, biomarker respones, and cancer. | Mutation research 20031101 |
| Odorants in breast milk. | Archives of pediatrics & adolescent medicine 20031001 |
| Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia. | Blood 20030701 |
| Diagnosis of fanconi anemia by diepoxybutane analysis. | Current protocols in human genetics 20030701 |
| Synthesis and characterization of peptides containing a cyclic Val adduct of diepoxybutane, a possible biomarker of human exposure to butadiene. | Chemical research in toxicology 20030501 |
| Role of haemoglobin in the protection of cultured lymphocytes against diepoxybutane (DEB), assessed by in vitro induced chromosome breakage. | Mutation research 20030420 |
| Differential diagnosis of Fanconi anemia by nitrogen mustard and diepoxybutane. | Annals of hematology 20030401 |
| A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene. | Environmental and molecular mutagenesis 20030101 |
| Mutations induced by 1,3-butadiene metabolites, butadiene diolepoxide, and 1,2,3,4-diepoxybutane at the Hprt locus in CHO-K1 cells. | Molecules and cells 20021231 |
| A novel diagnostic screen for defects in the Fanconi anemia pathway. | Blood 20021215 |
| Mutagenic spectrum of butadiene-derived N1-deoxyinosine adducts and N6,N6-deoxyadenosine intrastrand cross-links in mammalian cells. | Chemical research in toxicology 20021201 |
| Identification of the ribosomal proteins present in the vicinity of globin mRNA in the 40S initiation complex. | Journal of biochemistry 20021101 |
| The clastogenic response of the 1q12 heterochromatic region to DNA cross-linking agents is independent of the Fanconi anaemia pathway. | Carcinogenesis 20020801 |
| The donor substrate specificity of the human beta 1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residues. | The Journal of biological chemistry 20020712 |
| Sequence mapping of epoxide adducts in human hemoglobin with LC-tandem MS and the SALSA algorithm. | Chemical research in toxicology 20020601 |
| Biological effects of DNA damage in the hyperthermophilic archaeon Sulfolobus acidocaldarius. | FEMS microbiology letters 20020219 |
| Redox-modulated xenobiotic action and ROS formation: a mirror or a window? | Human & experimental toxicology 20020201 |
| Ion trap mass spectrometry in the structural analysis of haemoglobin peptides modified by epichlorohydrin and diepoxybutane. | Rapid communications in mass spectrometry : RCM 20020101 |
| Uterine-ovarian biochemical and developmental interactions to the postimplantation treatment with a butadiene metabolite, diepoxybutane, in pregnant rats. | Journal of biochemical and molecular toxicology 20020101 |
| Opposite responses in two DNA repair capacity tests in lymphocytes of head and neck cancer patients. | Journal of applied genetics 20020101 |
| Diepoxybutane. | Report on carcinogens : carcinogen profiles 20020101 |
| Detection of DNA adducts using a quantitative long PCR technique and the fluorogenic 5' nuclease assay (TaqMan). | Mutation research 20011212 |
| The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange. | Carcinogenesis 20011201 |
| Diepoxybutane and mitomycin C toxicity is associated with the induction of oxidative DNA damage in sea urchin embryos. | Human & experimental toxicology 20011201 |
| Genetic polymorphisms and chromosome damage. | International journal of hygiene and environmental health 20011001 |
| Diepoxybutane and diepoxyoctane interstrand cross-linking of the 5S DNA nucleosomal core particle. | Biochemistry 20010904 |
| Functional residues on the enzyme active site of glyoxalase I from bovine brain. | Preparative biochemistry & biotechnology 20010801 |
| Genetic damage by bifunctional agents in repair-active pre-meiotic stages of Drosophila males. | Mutation research 20010701 |
| Normal cellular radiosensitivity in an adult Fanconi anaemia patient with marked clinical radiosensitivity. | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20010701 |
| Genetic and reproductive toxicity of butadiene and isoprene. | Chemico-biological interactions 20010601 |
| First-pass metabolism of 1,3-butadiene in once-through perfused livers of rats and mice. | Chemico-biological interactions 20010601 |
| Physiological modeling of butadiene disposition in mice and rats. | Chemico-biological interactions 20010601 |
| Development of a preliminary physiologically based toxicokinetic (PBTK) model for 1,3-butadiene risk assessment. | Chemico-biological interactions 20010601 |
| Mutational spectrum of 1,3-butadiene and metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane to assess mutagenic mechanisms. | Chemico-biological interactions 20010601 |
| Using DNA and hemoglobin adducts to improve the risk assessment of butadiene. | Chemico-biological interactions 20010601 |
| Insights into the toxicokinetics and toxicodynamics of 1,3-butadiene. | Chemico-biological interactions 20010601 |
| A novel DNA adduct, originating from 1,2-epoxy-3,4-butanediol, is the major DNA adduct after exposure to [2,3-(14)C]-1,3-butadiene,[4-(14)C]-1,2-epoxy-3-butane. | Chemico-biological interactions 20010601 |
| In vitro genotoxicity testing of (1-chloroethenyl)oxirane, a metabolite of beta-chloroprene. | Chemico-biological interactions 20010601 |
| Synthesis and characterization of nucleosides and oligonucleotides bearing adducts of butadiene epoxides on adenine n(6) and guanine n(2). | Chemical research in toxicology 20010401 |
| Fanconi anemia. a statistical evaluation of cytogenetic results obtained from South African families. | Cancer genetics and cytogenetics 20010401 |
| Urinary butadiene diepoxide: a potential biomarker of blood diepoxide. | Toxicology 20010307 |
| Positional cloning of a novel Fanconi anemia gene, FANCD2. | Molecular cell 20010201 |
| Lung-specific mutagenicity and mutational spectrum in B6C3F1 lacI transgenic mice following inhalation exposure to 1,2-epoxybutene. | Mutation research 20010125 |
| Cytogenetic sensitivity of three Fanconi anemia heterozygotes to bleomycin and ionizing radiation. | Cancer genetics and cytogenetics 20010101 |
| A novel approach for identification and measurement of hemoglobin adducts with 1,2,3,4-diepoxybutane by liquid chromatography/electrospray ionisation mass spectrometry and matrix-assisted laser desorption/ionisation tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20010101 |
| Electrospray ionization detection of inherently nonresponsive epoxides by peptide binding. | Rapid communications in mass spectrometry : RCM 20010101 |
| Point mutations induced by 1,2-epoxy-3-butene N1 deoxyinosine adducts. | Environmental and molecular mutagenesis 20010101 |
| 1,3-butadiene: cancer, mutations, and adducts. Part I: Carcinogenicity of 1,2,3,4-diepoxybutane. | Research report (Health Effects Institute) 20000301 |
| Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium. | Carcinogenesis 19960101 |
| Enhancement of bacterial mutagenicity of bifunctional alkylating agents by expression of mammalian glutathione S-transferase. | Chemical research in toxicology 19950101 |
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