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145915-60-2 | 1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-
CAS No: 145915-60-2 Catalog No: AG001DIH MDL No:
Product Description
Catalog Number:
AG001DIH
Chemical Name:
1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-
CAS Number:
145915-60-2
Molecular Formula:
C20H13F2N3O2
Molecular Weight:
365.3329
IUPAC Name:
5,6-bis(4-fluoroanilino)isoindole-1,3-dione
InChI:
InChI=1S/C20H13F2N3O2/c21-11-1-5-13(6-2-11)23-17-9-15-16(20(27)25-19(15)26)10-18(17)24-14-7-3-12(22)4-8-14/h1-10,23-24H,(H,25,26,27)
InChI Key:
RONQPWQYDRPRGG-UHFFFAOYSA-N
SMILES:
Fc1ccc(cc1)Nc1cc2C(=O)NC(=O)c2cc1Nc1ccc(cc1)F
Properties
Complexity:
511
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
365.098g/mol
Formal Charge:
0
Heavy Atom Count:
27
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
365.34g/mol
Monoisotopic Mass:
365.098g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
70.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4
Literature
| Title | Journal |
|---|---|
| A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. | The Biochemical journal 20130415 |
| Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits. | Journal of vascular research 20120101 |
| Inhibition of protein kinase Cβ reverses increased blood-brain barrier permeability during hyperglycemic stroke and prevents edema formation in vivo. | Stroke 20111101 |
| Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. | Nature biotechnology 20111101 |
| Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin. | Journal of immunology (Baltimore, Md. : 1950) 20110601 |
| Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3. | Biochemical and biophysical research communications 20101105 |
| Thioflavin T fluorescence assay for beta-lactoglobulin fibrils hindered by DAPH. | Journal of structural biology 20090301 |
| Role of protein kinase C beta2 activation in TNF-alpha-induced human vascular endothelial cell apoptosis. | Canadian journal of physiology and pharmacology 20090301 |
| High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs. | American journal of physiology. Heart and circulatory physiology 20090101 |
| Inhibition of protein kinase C beta II downregulates tristetraprolin expression in activated macrophages. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080501 |
| Small-molecule aggregates inhibit amyloid polymerization. | Nature chemical biology 20080301 |
| Aggregator compounds confound amyloid fibrillization assay. | Nature chemical biology 20080301 |
| MetaSite: understanding metabolism in human cytochromes from the perspective of the chemist. | Journal of medicinal chemistry 20051103 |
| Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's disease via palladium-catalyzed amination. | The Journal of organic chemistry 20050902 |
| Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis. | The Journal of investigative dermatology 20030301 |
| Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors. | Cancer research 20010801 |
| A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells. | Molecular endocrinology (Baltimore, Md.) 19961001 |
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