200,000+ products from a single source!
sales@angenechem.com
145915-58-8 | 1H-Isoindole-1,3(2H)-dione, 5,6-bis(phenylamino)-
CAS No: 145915-58-8 Catalog No: AG001DII MDL No:
Product Description
Catalog Number:
AG001DII
Chemical Name:
1H-Isoindole-1,3(2H)-dione, 5,6-bis(phenylamino)-
CAS Number:
145915-58-8
Molecular Formula:
C20H15N3O2
Molecular Weight:
329.3520
IUPAC Name:
5,6-dianilinoisoindole-1,3-dione
InChI:
InChI=1S/C20H15N3O2/c24-19-15-11-17(21-13-7-3-1-4-8-13)18(12-16(15)20(25)23-19)22-14-9-5-2-6-10-14/h1-12,21-22H,(H,23,24,25)
InChI Key:
AAALVYBICLMAMA-UHFFFAOYSA-N
SMILES:
O=C1NC(=O)c2c1cc(Nc1ccccc1)c(c2)Nc1ccccc1
EC Number:
406-050-3
UNII:
Z13D008FZ2
Properties
Complexity:
453
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
329.116g/mol
Formal Charge:
0
Heavy Atom Count:
25
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
329.359g/mol
Monoisotopic Mass:
329.116g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
70.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.8
Literature
| Title | Journal |
|---|---|
| Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits. | Journal of vascular research 20120101 |
| Inhibition of protein kinase Cβ reverses increased blood-brain barrier permeability during hyperglycemic stroke and prevents edema formation in vivo. | Stroke 20111101 |
| Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3. | Biochemical and biophysical research communications 20101105 |
| Novel anilinophthalimide derivatives as potential probes for beta-amyloid plaque in the brain. | Bioorganic & medicinal chemistry 20100201 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Thioflavin T fluorescence assay for beta-lactoglobulin fibrils hindered by DAPH. | Journal of structural biology 20090301 |
| Role of protein kinase C beta2 activation in TNF-alpha-induced human vascular endothelial cell apoptosis. | Canadian journal of physiology and pharmacology 20090301 |
| High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs. | American journal of physiology. Heart and circulatory physiology 20090101 |
| Inhibition of protein kinase C beta II downregulates tristetraprolin expression in activated macrophages. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080501 |
| Small-molecule aggregates inhibit amyloid polymerization. | Nature chemical biology 20080301 |
| MetaSite: understanding metabolism in human cytochromes from the perspective of the chemist. | Journal of medicinal chemistry 20051103 |
| Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's disease via palladium-catalyzed amination. | The Journal of organic chemistry 20050902 |
| Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis. | The Journal of investigative dermatology 20030301 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Arterial epidermal growth factor receptor expression in deoxycorticosterone acetate-salt hypertension. | Hypertension (Dallas, Tex. : 1979) 20011201 |
| Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors. | Cancer research 20010801 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.