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145808-47-5 | L-Histidine, L-threonyl-L-isoleucyl-L-isoleucyl-L-asparaginyl-L-valyl-L-lysyl-L-cysteinyl-L-threonyl-L-seryl-L-prolyl-L-lysyl-L-glutaminyl-L-cysteinyl-L-leucyl-L-prolyl-L-prolyl-L-cysteinyl-L-lysyl-L-alanyl-L-glutaminyl-L-phenylalanylglycyl-L-glutaminyl-L-seryl-L-alanylglycyl-L-alanyl-L-lysyl-L-cysteinyl-L-methionyl-L-asparaginylglycyl-L-lysyl-L-cysteinyl-L-lysyl-L-cysteinyl-L-tyrosyl-L-prolyl-, cyclic (7→29),(13→34),(17→36)-tris(disulfide)
CAS No: 145808-47-5 Catalog No: AG001DEX MDL No:
Product Description
Catalog Number:
AG001DEX
Chemical Name:
L-Histidine, L-threonyl-L-isoleucyl-L-isoleucyl-L-asparaginyl-L-valyl-L-lysyl-L-cysteinyl-L-threonyl-L-seryl-L-prolyl-L-lysyl-L-glutaminyl-L-cysteinyl-L-leucyl-L-prolyl-L-prolyl-L-cysteinyl-L-lysyl-L-alanyl-L-glutaminyl-L-phenylalanylglycyl-L-glutaminyl-L-seryl-L-alanylglycyl-L-alanyl-L-lysyl-L-cysteinyl-L-methionyl-L-asparaginylglycyl-L-lysyl-L-cysteinyl-L-lysyl-L-cysteinyl-L-tyrosyl-L-prolyl-, cyclic (7→29),(13→34),(17→36)-tris(disulfide)
CAS Number:
145808-47-5
IUPAC Name:
2-[[1-[2-[[40-[[6-amino-2-[[2-[[4-amino-2-[[2-[[2-[(2-amino-3-hydroxybutanoyl)amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]-25,48,78,88,94-pentakis(4-aminobutyl)-a-(2-amino-2-oxoethyl)-22,63,72-tris(3-amino-3-oxopropyl)-69-benzyl-37-(1-hydroxyethyl)-34,60-bis(hydroxymethyl)-51,57,75-trimethyl-16-(2-methylpropyl)-3a-(2-methylsulfanylethyl)-2a,3,5a,9,15,18,21,24,27,33,36,39,47,50,53,56,59,62,65,68,71,74,77,80,87,90,93,96,99-nonacosaoxo-7a,8a,42,43,82,83-hexathia-1a,2,4a,8,14,17,20,23,26,32,35,38,46,49,52,55,58,61,64,67,70,73,76,79,86,89,92,95,98-nonacosazahexacyclo[43.35.25.419,91.04,8.010,14.028,32]nonahectane-85-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-4-yl)propanoic acid
InChI:
InChI=1S/C178H286N52O50S7/c1-15-91(7)140(225-172(273)141(92(8)16-2)224-169(270)138(190)96(12)233)171(272)211-114(75-134(189)240)158(259)223-139(90(5)6)170(271)208-107(43-25-31-64-184)153(254)221-125-87-287-283-83-121-161(262)206-111(58-69-281-14)157(258)210-113(74-133(188)239)147(248)194-78-136(242)199-102(38-20-26-59-179)149(250)217-120-82-282-284-84-122(220-156(257)110(54-57-132(187)238)205-150(251)106(42-24-30-63-183)207-166(267)126-44-33-66-228(126)176(277)119(81-232)216-173(274)142(97(13)234)226-165(125)266)163(264)212-115(70-89(3)4)174(275)230-68-35-47-129(230)177(278)229-67-34-46-128(229)168(269)222-124(86-286-285-85-123(219-152(253)105(204-160(120)261)41-23-29-62-182)164(265)213-116(72-99-48-50-101(235)51-49-99)175(276)227-65-32-45-127(227)167(268)214-117(178(279)280)73-100-76-191-88-195-100)162(263)203-103(39-21-27-60-180)148(249)198-95(11)145(246)202-109(53-56-131(186)237)155(256)209-112(71-98-36-18-17-19-37-98)146(247)193-79-137(243)200-108(52-55-130(185)236)154(255)215-118(80-231)159(260)197-93(9)143(244)192-77-135(241)196-94(10)144(245)201-104(151(252)218-121)40-22-28-61-181/h17-19,36-37,48-51,76,88-97,102-129,138-142,231-235H,15-16,20-35,38-47,52-75,77-87,179-184,190H2,1-14H3,(H2,185,236)(H2,186,237)(H2,187,238)(H2,188,239)(H2,189,240)(H,191,195)(H,192,244)(H,193,247)(H,194,248)(H,196,241)(H,197,260)(H,198,249)(H,199,242)(H,200,243)(H,201,245)(H,202,246)(H,203,263)(H,204,261)(H,205,251)(H,206,262)(H,207,267)(H,208,271)(H,209,256)(H,210,258)(H,211,272)(H,212,264)(H,213,265)(H,214,268)(H,215,255)(H,216,274)(H,217,250)(H,218,252)(H,219,253)(H,220,257)(H,221,254)(H,222,269)(H,223,259)(H,224,270)(H,225,273)(H,226,266)(H,279,280)
InChI Key:
OVJBOPBBHWOWJI-UHFFFAOYSA-N
SMILES:
NCCCCC1NC(=O)C(C)NC(=O)CNC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCC(=O)N)NC(=O)CNC(=O)C(Cc2ccccc2)NC(=O)C(CCC(=O)N)NC(=O)C(C)NC(=O)C(CCCCN)NC(=O)C2CSSCC(NC(=O)C(NC(=O)C3NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CSSCC(NC(=O)C(NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(C(CC)C)NC(=O)C(C(CC)C)NC(=O)C(C(O)C)N)CC(=O)N)CCCCN)C(=O)NC(C(O)C)C(=O)NC(CO)C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)NC(CCC(=O)N)C(=O)NC(CSSC3)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)N2)CCSC)CC(=O)N)CCCCN)CCCCN)C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)O)Cc1c[nH]cn1)Cc1ccc(cc1)O
Properties
Complexity:
9830
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
4176.951g/mol
Formal Charge:
0
Heavy Atom Count:
287
Hydrogen Bond Acceptor Count:
65
Hydrogen Bond Donor Count:
53
Isotope Atom Count:
0
Molecular Weight:
4178.98g/mol
Monoisotopic Mass:
4175.948g/mol
Rotatable Bond Count:
75
Topological Polar Surface Area:
1810A^2
Undefined Atom Stereocenter Count:
40
Undefined Bond Stereocenter Count:
0
XLogP3:
-14.9
Literature
| Title | Journal |
|---|---|
| Effect of methamphetamine on the microglial damage: role of potassium channel Kv1.3. | PloS one 20140101 |
| Different potassium channels are involved in relaxation of rat renal artery induced by P1075. | Basic & clinical pharmacology & toxicology 20120701 |
| Involvement of Kv1.3 and p38 MAPK signaling in HIV-1 glycoprotein 120-induced microglia neurotoxicity. | Cell death & disease 20120101 |
| Mature and precursor brain-derived neurotrophic factor have individual roles in the mouse olfactory bulb. | PloS one 20120101 |
| Evidence for aconitine-induced inhibition of delayed rectifier K(+) current in Jurkat T-lymphocytes. | Toxicology 20111028 |
| Pharmacological inhibition of Kv1.3 fails to modulate insulin sensitivity in diabetic mice or human insulin-sensitive tissues. | American journal of physiology. Endocrinology and metabolism 20110801 |
| KCNQ5 channels control resting properties and release probability of a synapse. | Nature neuroscience 20110701 |
| Kv1.3 channels regulate synaptic transmission in the nucleus of solitary tract. | Journal of neurophysiology 20110601 |
| Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers. | Cardiovascular research 20110201 |
| Membrane potential of CD4+ T cells is a subset specific feature that depends on the direct cell-to-cell contacts with monocytes. | Human immunology 20100701 |
| Bursts and hyperexcitability in non-myelinated axons of the rat hippocampus. | Neuroscience 20100602 |
| Functional evidence for oxygen-sensitive voltage-gated potassium channels in human placental vasculature. | Placenta 20100601 |
| Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count. | The Journal of physiology 20100501 |
| Targeting K(V) channels rescues retinal ganglion cells in vivo directly and by reducing inflammation. | Channels (Austin, Tex.) 20100101 |
| Characterisation of K+ currents in the C8-B4 microglial cell line and their regulation by microglia activating stimuli. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101 |
| Ca2+-dependent functions in peptidoglycan-stimulated mouse dendritic cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101 |
| Kv1.3 channels in postganglionic sympathetic neurons: expression, function, and modulation. | American journal of physiology. Regulatory, integrative and comparative physiology 20080901 |
| Kv1 and Kir2 potassium channels are expressed in rat brain endothelial cells. | Pflugers Archiv : European journal of physiology 20080501 |
| Study of membrane potential in T lymphocytes subpopulations using flow cytometry. | BMC immunology 20080101 |
| Minocycline decreases in vitro microglial motility, beta1-integrin, and Kv1.3 channel expression. | Journal of neurochemistry 20071201 |
| Developmental changes in potassium currents at the rat calyx of Held presynaptic terminal. | The Journal of physiology 20070615 |
| A cell-based Rb(+)-flux assay of the Kv1.3 potassium channel. | Assay and drug development technologies 20070601 |
| Potassium channels-mediated vasorelaxation of rat aorta induced by resveratrol. | Basic & clinical pharmacology & toxicology 20061101 |
| [Inhibition of human macrophage-derived foam cell differentiation by blocking Kv1.3 and Kir2.1 channels]. | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20060801 |
| Inhibitory effects of blocking voltage-dependent potassium channel 1.3 on human monocyte-derived macrophage differentiation into foam cells. | Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20060618 |
| The mechanism of endothelium-independent relaxation induced by the wine polyphenol resveratrol in human internal mammary artery. | Journal of pharmacological sciences 20060501 |
| Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism. | American journal of physiology. Cell physiology 20060201 |
| Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic beta-cells. | The Journal of physiology 20050815 |
| Peripheral and spinal mechanisms of antinociceptive action of lumiracoxib. | European journal of pharmacology 20050418 |
| Kv1 K+ channels control Purkinje cell output to facilitate postsynaptic rebound discharge in deep cerebellar neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050209 |
| Increase of delayed rectifier potassium currents in large aspiny neurons in the neostriatum following transient forebrain ischemia. | Neuroscience 20050101 |
| Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric oxide production of human endothelial cells. | Journal of vascular research 20050101 |
| Volume regulation of mature and immature spermatozoa in a primate model, and possible ion channels involved. | Human reproduction (Oxford, England) 20041101 |
| Kv1.3 channel gene-targeted deletion produces 'Super-Smeller Mice' with altered glomeruli, interacting scaffolding proteins, and biophysics. | Neuron 20040205 |
| Predominant expression of Kv1.3 voltage-gated K+ channel subunit in rat prostate cancer cell lines: electrophysiological, pharmacological and molecular characterisation. | Pflugers Archiv : European journal of physiology 20030801 |
| Immunosuppressive effects of a Kv1.3 inhibitor. | Cellular immunology 20030201 |
| Potassium channel antagonists influence porcine granulosa cell proliferation, differentiation, and apoptosis. | Biology of reproduction 20020701 |
| IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1. | Pflugers Archiv : European journal of physiology 20020201 |
| Three types of depolarization-activated potassium currents in acutely isolated mouse vestibular neurons. | Journal of neurophysiology 20010301 |
| Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3. | Biochemistry 19990420 |
| Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel. | The American journal of physiology 19980901 |
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