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145781-92-6

145781-92-6 | 1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1-dimethylethyl)-D-serine]-, 2-(aminocarbonyl)hydrazide, acetate (1:?)

CAS No: 145781-92-6 Catalog No: AG001DEH MDL No:

Product Description

Catalog Number:
AG001DEH
Chemical Name:
1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1-dimethylethyl)-D-serine]-, 2-(aminocarbonyl)hydrazide, acetate (1:?)
CAS Number:
145781-92-6
Molecular Formula:
C61H88N18O16
Molecular Weight:
1329.4624
IUPAC Name:
acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
InChI:
InChI=1S/C59H84N18O14.C2H4O2/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38;1-2(3)4/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90);1H3,(H,3,4)/t38-,39-,40-,41-,42-,43-,44-,45+,46-;/m0./s1
InChI Key:
IKDXDQDKCZPQSZ-JHYYTBFNSA-N
SMILES:
CC(=O)O.OC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)NNC(=O)N)CCCNC(=N)N)CC(C)C)COC(C)(C)C)Cc1ccc(cc1)O)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H]1CCC(=O)N1)Cc1nc[nH]c1
UNII:
6YUU2PV0U8

Properties

Complexity:
2590  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
9  
Defined Bond Stereocenter Count:
0
Exact Mass:
1328.663g/mol
Formal Charge:
0
Heavy Atom Count:
95  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
18  
Isotope Atom Count:
0
Molecular Weight:
1329.485g/mol
Monoisotopic Mass:
1328.663g/mol
Rotatable Bond Count:
32  
Topological Polar Surface Area:
533A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Literature

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Defining biochemical failure after radiotherapy with and without androgen deprivation for prostate cancer. International journal of radiation oncology, biology, physics 20051201
The biology of steroid hormones and endocrine treatment of breast cancer. Breast (Edinburgh, Scotland) 20051201
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Assessment of ovarian failure and osteoporosis in premenopausal breast cancer survivors. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20050601
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Gonadal protection by a gonadotropin-releasing hormone agonist depot in young women with Hodgkin's disease undergoing chemotherapy. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20050501
Docetaxel followed by hormone therapy in men experiencing increasing prostate-specific antigen after primary local treatments for prostate cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050420
Controlled release of goserelin from microporous polyglycolide and polylactide. Macromolecular bioscience 20050419
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The effect of physical training on bone mineral density in women with endometriosis treated with GnRH analogs: a pilot study. Acta obstetricia et gynecologica Scandinavica 20050401
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Final adult height and body mass index after cure of paediatric Cushing's disease. Clinical endocrinology 20050401
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Endometrial resection and preoperative LH-RH agonists: a prospective 5-year trial. European journal of obstetrics, gynecology, and reproductive biology 20050301
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Clinical role of multidrug resistance protein 1 expression in chemotherapy resistance in early-stage breast cancer: the Austrian Breast and Colorectal Cancer Study Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050220
A randomised factorial trial of sequential doxorubicin and CMF vs CMF and chemotherapy alone vs chemotherapy followed by goserelin plus tamoxifen as adjuvant treatment of node-positive breast cancer. British journal of cancer 20050214
Androgen suppression plus radiation versus radiation alone for patients with stage D1/pathologic node-positive adenocarcinoma of the prostate: updated results based on national prospective randomized trial Radiation Therapy Oncology Group 85-31. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050201
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Randomized controlled trial to evaluate radiotherapy +/- endocrine therapy versus endocrine therapy alone for PSA failure after radical prostatectomy: Japan Clinical Oncology Group Study JCOG 0401. Japanese journal of clinical oncology 20050101
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Comparative study of different dosages of goserelin in size reduction of myomatous uteri. The Journal of the American Association of Gynecologic Laparoscopists 20041101
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Fatal acute tumor lysis syndrome, hepatic encephalopathy and flare phenomenon following combined androgen blockade. The Journal of urology 20040401
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The influence of cisplatinum and goserelinum on the magnesium and calcium level in rat serum. Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20010101
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