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145231-35-2 | Carbamimidothioic acid, N-[(4-chlorophenyl)methyl]-, 3-(1H-imidazol-5-yl)propyl ester, hydrobromide (1:2)
CAS No: 145231-35-2 Catalog No: AG001KP2 MDL No:MFCD00467655
Product Description
Catalog Number:
AG001KP2
Chemical Name:
Carbamimidothioic acid, N-[(4-chlorophenyl)methyl]-, 3-(1H-imidazol-5-yl)propyl ester, hydrobromide (1:2)
CAS Number:
145231-35-2
Molecular Formula:
C14H19Br2ClN4S
Molecular Weight:
470.6535
MDL Number:
MFCD00467655
IUPAC Name:
3-(1H-imidazol-5-yl)propyl N'-[(4-chlorophenyl)methyl]carbamimidothioate;dihydrobromide
InChI:
InChI=1S/C14H17ClN4S.2BrH/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13;;/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19);2*1H
InChI Key:
JIJQPEZAVLJZBO-UHFFFAOYSA-N
SMILES:
N=C(NCc1ccc(cc1)Cl)SCCCc1cnc[nH]1.Br.Br
Properties
Complexity:
306
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
469.937g/mol
Formal Charge:
0
Heavy Atom Count:
22
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
470.652g/mol
Monoisotopic Mass:
467.939g/mol
Rotatable Bond Count:
7
Topological Polar Surface Area:
92.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
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|---|---|
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| The histamine H4 receptor is functionally expressed on T(H)2 cells. | The Journal of allergy and clinical immunology 20090301 |
| The role of histamine 3 receptors in the control of food intake in a seasonal model of obesity: the Siberian hamster. | Behavioural pharmacology 20090301 |
| Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation. | Experimental dermatology 20090101 |
| Histamine H4 receptors modulate dendritic cell migration through skin--immunomodulatory role of histamine. | Allergy 20081001 |
| Electrophysiology-based analysis of human histamine H(4) receptor pharmacology using GIRK channel coupling in Xenopus oocytes. | European journal of pharmacology 20080904 |
| Apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats is increased by histidine and decreased by histidine decarboxylase, histamine H1 and H2 receptor antagonists, and an H3 receptor agonist. | Pharmacology, biochemistry, and behavior 20080901 |
| Substance P is involved in the effect of histamine H3 receptor agonist, Sch 50971 on nasal allergic symptoms in mice. | International immunopharmacology 20080801 |
| Comparison of the effect of an H(3)-inverse agonist on energy intake and hypothalamic histamine release in normal mice and leptin resistant mice with high fat diet-induced obesity. | Behavioural brain research 20080409 |
| Efficient approaches to S-alkyl-N-alkylisothioureas: syntheses of histamine H3 antagonist clobenpropit and its analogues. | The Journal of organic chemistry 20080321 |
| Carnosine protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cells. | Cellular and molecular neurobiology 20080201 |
| The role of histamine in human mammary carcinogenesis: H3 and H4 receptors as potential therapeutic targets for breast cancer treatment. | Cancer biology & therapy 20080101 |
| Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. | The Journal of allergy and clinical immunology 20070801 |
| The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes. | European journal of pharmacology 20070719 |
| The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. | European journal of pharmacology 20070601 |
| Histamine H3-receptor agonists and imidazole-based H3-receptor antagonists can be thermodynamically discriminated. | British journal of pharmacology 20070601 |
| Correlation of apparent affinity values from H3-receptor binding assays with apparent affinity (pKapp) and intrinsic activity (alpha) from functional bioassays. | British journal of pharmacology 20070501 |
| Role of histamine in ghrelin-induced gastroprotection against acute gastric lesions. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20070401 |
| [Reversing effect of histamine on neurotoxicity induced by beta-amyloid1-42]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070301 |
| Pre-synaptic histamine H3 receptors regulate glutamate, but not GABA release in rat thalamus. | Neuropharmacology 20070201 |
| Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. | Neuropharmacology 20060901 |
| Detection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand. | British journal of pharmacology 20060701 |
| Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. | Journal of neurophysiology 20060401 |
| Probing the importance of N-glycosylation for [(3)H] clobenpropit binding to human H (3) receptors expressed in HEK 293 cells . 3. Molecular and chemical aspects of the histamine receptors. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060401 |
| Histamine increases sickle erythrocyte adherence to endothelium. | British journal of haematology 20060201 |
| Histaminergic neurons protect the developing hippocampus from kainic acid-induced neuronal damage in an organotypic coculture system. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060125 |
| Effects of intracerebroventricular administration of ultra low doses of histaminergic drugs on morphine state-dependent memory of passive avoidance in mice. | Behavioural brain research 20060106 |
| Histamine (H3) receptors modulate the excitatory amino acid receptor response of the vestibular afferents. | Brain research 20051207 |
| Histamine-3 receptor antagonists reduce superoxide anion generation and lipid peroxidation in rat brain homogenates. | The Journal of pharmacy and pharmacology 20050601 |
| Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. | Journal of immunology (Baltimore, Md. : 1950) 20050501 |
| Inhibition of tryptase release from human colon mast cells by histamine receptor antagonists. | Asian Pacific journal of allergy and immunology 20050301 |
| Histamine H3 receptors modulate reactive hyperemia in rat gut. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040901 |
| Presynaptic cannabinoid CB(1) receptors are involved in the inhibition of the neurogenic vasopressor response during septic shock in pithed rats. | British journal of pharmacology 20040601 |
| Ligand identification for G-protein-coupled receptors: a lead generation perspective. | Current opinion in chemical biology 20040601 |
| Effect of the histamine H3-antagonist clobenpropit on spatial memory deficits induced by MK-801 as evaluated by radial maze in Sprague-Dawley rats. | Behavioural brain research 20040505 |
| [Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20040501 |
| Intracerebroventricular administration of histamine H3 receptor antagonists decreases seizures in rat models of epilepsia. | Methods and findings in experimental and clinical pharmacology 20040501 |
| Histamine h3 receptor antagonists potentiate methamphetamine self-administration and methamphetamine-induced accumbal dopamine release. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040401 |
| Involvement of central and peripheral histamine H(3) receptors in the control of the vascular tone and oxygen uptake in the mesenteric circulation of the rat. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040301 |
| Effects of clobenpropit on pentylenetetrazole-kindled seizures in rats. | European journal of pharmacology 20031215 |
| Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor. | British journal of pharmacology 20031101 |
| Histamine H3 receptors regulate vascular permeability changes in the skin of mast cell-deficient mice. | International immunopharmacology 20031101 |
| Effects of endogenous histamine on seizure development of pentylenetetrazole-induced kindling in rats. | Pharmacology 20030901 |
| Molecular and pharmacological characterization of the mouse histamine H3 receptor. | European journal of pharmacology 20030425 |
| Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. | British journal of pharmacology 20021101 |
| Presynaptic H3 autoreceptors modulate histamine synthesis through cAMP pathway. | Molecular pharmacology 20020101 |
| Dynamics of histamine H(3) receptor antagonists on brain histamine metabolism: do all histamine H(3) receptor antagonists act at a single site? | European journal of pharmacology 20011116 |
| Histamine H3 receptor-mediated inhibition of sympathetically evoked mydriasis in rats. | European journal of pharmacology 20010504 |
| Histamine H(3) receptor-mediated inhibition of depolarization-induced, dopamine D(1) receptor-dependent release of [(3)H]-gamma-aminobutryic acid from rat striatal slices. | British journal of pharmacology 20010501 |
| Effect of clobenpropit on regional cerebral blood flow in rat hippocampus. | Acta pharmacologica Sinica 20010401 |
| Identification of a histamine H(3)-like receptor in the zebrafish (Danio rerio) brain. | Journal of neurochemistry 20000801 |
| Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia. | Behavioural brain research 19991001 |
| Histamine inhibits the production of interleukin-12 through interaction with H2 receptors. | The Journal of clinical investigation 19981115 |
| Effect of interleukin-1beta on the ascending and descending reflex in rat small intestine. | European journal of pharmacology 19981023 |
| Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats. | Naunyn-Schmiedeberg's archives of pharmacology 19970201 |
| Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian hamster. | Endocrinology |
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