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145-42-6 | Ethanesulfonic acid, 2-[[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)
CAS No: 145-42-6 Catalog No: AG001KFO MDL No:MFCD00150819
Product Description
Catalog Number:
AG001KFO
Chemical Name:
Ethanesulfonic acid, 2-[[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)
CAS Number:
145-42-6
Molecular Formula:
C26H44NNaO7S
Molecular Weight:
537.6848
MDL Number:
MFCD00150819
IUPAC Name:
sodium;2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonate
InChI:
InChI=1S/C26H45NO7S.Na/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29;/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-;/m1./s1
InChI Key:
JAJWGJBVLPIOOH-IZYKLYLVSA-M
SMILES:
O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)NCCS(=O)(=O)[O-])C)C)O)C.[Na+]
EC Number:
205-653-7
UNII:
M6N3TH81NO
Properties
Complexity:
897
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
11
Defined Bond Stereocenter Count:
0
Exact Mass:
537.274g/mol
Formal Charge:
0
Heavy Atom Count:
36
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
537.688g/mol
Monoisotopic Mass:
537.274g/mol
Rotatable Bond Count:
7
Topological Polar Surface Area:
155A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
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| Formation of nano/micro-dispersions with improved dissolution properties upon dispersion of ritonavir melt extrudate in aqueous media. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100416 |
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| Cloning/characterization of the canine organic anion transporting polypeptide 1b4 (Oatp1b4) and classification of the canine OATP/SLCO members. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20100401 |
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| Measurement of bile salt export pump transport activities using a fluorescent bile acid derivative. | Drug metabolism and pharmacokinetics 20100101 |
| Effect of procainhydrochloride on phospholipase A2 catalytic activity in sodium taurocholate-induced acute experimental pancreatitis in rats. | Digestive diseases (Basel, Switzerland) 20100101 |
| Delayed production of IL-18 in lungs and pancreas of rats with acute pancreatitis. | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20100101 |
| A simple taurocholate-induced model of severe acute pancreatitis in rats. | World journal of gastroenterology 20091207 |
| The selective inhibition of type IV phosphodiesterase attenuates the severity of the acute pancreatitis in rats. | Digestive diseases and sciences 20091201 |
| Interaction of macrolide antibiotics with intestinally expressed human and rat organic anion-transporting polypeptides. | Drug metabolism and disposition: the biological fate of chemicals 20091201 |
| PKC{epsilon}-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line. | American journal of physiology. Gastrointestinal and liver physiology 20091201 |
| A photophysical study on the role of bile salt hydrophobicity in solubilizing amphotericin B aggregates. | Journal of pharmaceutical sciences 20091101 |
| A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20091101 |
| Effect of baicalin and octreotide on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis. | Journal of gastroenterology and hepatology 20091101 |
| Effects of etanercept on sodium taurocholate-induced acute pancreatitis in rats. | Translational research : the journal of laboratory and clinical medicine 20091101 |
| Taurine-deficient diet up-regulated cystathionine beta-synthase monoallele in hemizygous cystathionine beta-synthase knockout mice. | Nutrition research (New York, N.Y.) 20091101 |
| New ideas about the solubility of drugs. | Chemistry & biodiversity 20091101 |
| Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. | Gastroenterology 20091001 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| In vitro bile acid binding and short-chain fatty acid profile of flax fiber and ethanol co-products. | Journal of medicinal food 20091001 |
| Bile acid transport in hypercholesterolemic resistant rabbits. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090901 |
| In vitro inhibition of OATP-mediated uptake of phalloidin using bile acid derivatives. | Toxicology and applied pharmacology 20090815 |
| Thermodynamics and structure of inclusion compounds of tauro- and glyco-conjugated bile salts and beta-cyclodextrin. | Physical chemistry chemical physics : PCCP 20090707 |
| Down-regulation of hypoxia-inducible factor-1alpha by hyperbaric oxygen attenuates the severity of acute pancreatitis in rats. | Pancreas 20090701 |
| Acute pancreatitis: hypertonic saline increases heat shock proteins 70 and 90 and reduces neutrophil infiltration in lung injury. | Pancreas 20090701 |
| Identification, release and olfactory detection of bile salts in the intestinal fluid of the Senegalese sole (Solea senegalensis). | Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20090701 |
| Mutational analysis of uncharged polar residues and proline in the distal one-third (Thr130-Pro142) of the highly conserved region of mouse Slc10a2. | Bioscience, biotechnology, and biochemistry 20090701 |
| Polyproline-type helical-structured low-molecular weight heparin (LMWH)-taurocholate conjugate as a new angiogenesis inhibitor. | International journal of cancer 20090615 |
| Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation. | Journal of lipid research 20090601 |
| [Expression of survivin gene in a rat model of acute pancreatitis]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090601 |
| Taurocholate potentiates ethanol-induced NF-kappaB activation and inhibits caspase-3 activity in cultured rat gastric mucosal cells. | Digestive diseases and sciences 20090501 |
| Participation of asparagine 370 and glutamine 235 in the catalysis by acid beta-glucosidase: the enzyme deficient in Gaucher disease. | Molecular genetics and metabolism 20090501 |
| Taurocholate feeding to bile duct ligated rats prevents caffeic acid-induced bile duct damage by changes in cholangiocyte VEGF expression. | Experimental biology and medicine (Maywood, N.J.) 20090401 |
| The proteome of mesenteric lymph during acute pancreatitis and implications for treatment. | JOP : Journal of the pancreas 20090309 |
| Solvent-mediated solid phase transformations of carbamazepine: Effects of simulated intestinal fluid and fasted state simulated intestinal fluid. | Journal of pharmaceutical sciences 20090301 |
| Caerulein or taurocholate induced enzymatic and histologic alterations in the isolated perfused rat pancreas. | Langenbeck's archives of surgery 20090301 |
| Endogenous catecholamine stimulates alveolar fluid clearance in rats with acute pancreatitis. | Respirology (Carlton, Vic.) 20090301 |
| Transbuccal delivery of 5-fluorouracil: permeation enhancement and pharmacokinetic study. | AAPS PharmSciTech 20090301 |
| [Effect of resveratrol-induced FasL up-regulation on the apoptosis of pancreatic acinar cells in rats with severe acute pancreatitis]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090301 |
| Does the 3-aminobenzamide effect on bacterial translocation affect experimental acute necrotizing pancreatitis? | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20090301 |
| Novel oral absorption system containing polyamines and bile salts enhances drug transport via both transcellular and paracellular pathways across Caco-2 cell monolayers. | International journal of pharmaceutics 20090209 |
| Cell-permeable Tat-NBD peptide attenuates rat pancreatitis and acinus cell inflammation response. | World journal of gastroenterology 20090207 |
| Saline infusion through the pancreatic duct leads to changes in calcium homeostasis similar to those observed in acute pancreatitis. | Digestive diseases and sciences 20090201 |
| Solubilisation of dipalmitoylphosphatidylcholine bilayers by sodium taurocholate: a model to study the stability of liposomes in the gastrointestinal tract and their mechanism of interaction with a model bile salt. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090201 |
| Surfactant-induced mobilisation of trace metals from estuarine sediment: implications for contaminant bioaccessibility and remediation. | Environmental pollution (Barking, Essex : 1987) 20090201 |
| Colloidal structures in media simulating intestinal fed state conditions with and without lipolysis products. | Pharmaceutical research 20090201 |
| Fibrogenesis in pediatric cholestatic liver disease: role of taurocholate and hepatocyte-derived monocyte chemotaxis protein-1 in hepatic stellate cell recruitment. | Hepatology (Baltimore, Md.) 20090201 |
| Matrix metalloproteinase-9 derived from polymorphonuclear neutrophils increases gut barrier dysfunction and bacterial translocation in rat severe acute pancreatitis. | Surgery 20090201 |
| Rosiglitazone attenuates the severity of sodium taurocholate-induced acute pancreatitis and pancreatitis-associated lung injury. | Archives of medical research 20090201 |
| Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human. | Xenobiotica; the fate of foreign compounds in biological systems 20090201 |
| Transport evaluation of alendronate across Caco-2 cell monolayers. | Die Pharmazie 20090201 |
| Involvement of prostacyclin/IP receptors in decreased acid response of damaged stomachs--mediation by somatostatin/SST2 receptors. | Life sciences 20090130 |
| Administration of anti-Reg I and anti-PAPII antibodies worsens pancreatitis. | JOP : Journal of the pancreas 20090108 |
| Effect of platelet-activating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity. | Pancreas 20090101 |
| On enhancers and inhibitors of elastin-derived amyloidogenesis. | Nanomedicine (London, England) 20090101 |
| Rosiglitazone, a peroxisome proliferator-activated receptor gamma (PPARgamma)-specific agonist, as a modulator in experimental acute pancreatitis. | Medical science monitor : international medical journal of experimental and clinical research 20090101 |
| Erythropoietin: a possible cytoprotective cytokine in acute necrotizing pancreatitis. | Journal of hepato-biliary-pancreatic surgery 20090101 |
| Identification, expression, and functional characterization of full-length and splice variants of murine organic anion transporting polypeptide 1b2. | Molecular pharmaceutics 20090101 |
| Development of mucoadhesive buccal films for the treatment of oral sub-mucous fibrosis: a preliminary study. | Pharmaceutical development and technology 20090101 |
| In vitro, but not in vivo, reversibility of peritoneal macrophages activation during experimental acute pancreatitis. | BMC immunology 20090101 |
| Physicochemical and biological characterization of monoketocholic acid, a novel permeability enhancer. | Molecular pharmaceutics 20090101 |
| Biliary sphincterotomy does not relate to diarrhoea or major changes in bile acid synthesis or plasma lipids. | Scandinavian journal of gastroenterology 20090101 |
| Physicochemical properties and antioxidant activity of gamma-oryzanol-loaded liposome formulations for topical use. | Pharmaceutical development and technology 20090101 |
| Recent advances in the understanding of bile acid malabsorption. | British medical bulletin 20090101 |
| Taurocholate-induced nitric oxide signaling and the ensuing production of reactive oxygen species lead to an increase in epithelial permeability in cultivated mouse gastric epithelium. | Digestive diseases and sciences 20081201 |
| Evaluation of the probiotic characteristics of newly isolated lactic acid bacteria. | Applied biochemistry and biotechnology 20081201 |
| Involvement of intestinal uptake transporters in the absorption of azithromycin and clarithromycin in the rat. | Drug metabolism and disposition: the biological fate of chemicals 20081201 |
| Influence of La3+ ions on the egg-yolk phosphatidylcholine and sodium taurocholate self-assemblies in aqueous suspension. | Journal of colloid and interface science 20081201 |
| Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening. | Combinatorial chemistry & high throughput screening 20081201 |
| Physical and chemical factors influencing the germination of Clostridium difficile spores. | Journal of applied microbiology 20081201 |
| Study on protecting effects of baicalin and octreotide on hepatic injury in rats with severe acute pancreatitis. | World journal of gastroenterology 20081114 |
| The bile acid turnover rate assessed with the (75)SeHCAT test is stable in chronic diarrhoea but slightly decreased in healthy subjects after a long period of time. | Digestive diseases and sciences 20081101 |
| Cardiovascular homeostasis in hypotension associated with initial stages of severe acute pancreatitis. | Pancreas 20081101 |
| Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins. | Biopharmaceutics & drug disposition 20081101 |
| Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. | Journal of medicinal chemistry 20081009 |
| Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus. | American journal of physiology. Regulatory, integrative and comparative physiology 20081001 |
| Effect of albumin on the biliary clearance of compounds in sandwich-cultured rat hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20081001 |
| Surfactant dependent morphology of polymeric capsules of perfluorooctyl bromide: influence of polymer adsorption at the dichloromethane-water interface. | Journal of colloid and interface science 20081001 |
| Cholangiocyte bile salt transporters in cholesterol gallstone-susceptible and resistant inbred mouse strains. | Journal of gastroenterology and hepatology 20081001 |
| Study of the protective effects of dexamethasone on ileum mucosa injury in rats with severe acute pancreatitis. | Pancreas 20081001 |
| The effect of synacthen on acute necrotizing pancreatitis in rats. | Pancreas 20081001 |
| Study of thermodynamic parameters for solubilization of plant sterol and stanol in bile salt micelles. | Chemistry and physics of lipids 20080801 |
| Improvement of monocyte secretion function in a porcine pancreatitis model by continuous dose dependent veno-venous hemofiltration. | The International journal of artificial organs 20080801 |
| Statin pretreatment in experimental acute pancreatitis. | JOP : Journal of the pancreas 20080710 |
| Different bacterial strategies to degrade taurocholate. | Archives of microbiology 20080701 |
| Niemann-pick C1-like 1 mediates alpha-tocopherol transport. | Molecular pharmacology 20080701 |
| Cytosol-nucleus traffic and colocalization with FXR of conjugated bile acids in rat hepatocytes. | American journal of physiology. Gastrointestinal and liver physiology 20080701 |
| Alpha-tocopheryl acetate is absorbed and hydrolyzed by Caco-2 cells comparative studies with alpha-tocopherol. | Chemistry and physics of lipids 20080701 |
| Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis. | Pancreas 20080701 |
| Proteasome inhibitor ameliorates severe acute pancreatitis and associated lung injury of rats. | World journal of gastroenterology 20080528 |
| Small-interference RNA gene knockdown of pancreatitis-associated proteins in rat acute pancreatitis. | Pancreas 20080501 |
| Permeation studies and histological examination of sheep nasal mucosa following administration of different nasal formulations with or without absorption enhancers. | Drug delivery 20080501 |
| In vitro methods can forecast the effects of intragastric residence on dosage form performance. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20080423 |
| Glutamate cysteine ligase up-regulation fails in necrotizing pancreatitis. | Free radical biology & medicine 20080415 |
| Metabolism and disposition of resveratrol in the isolated perfused rat liver: role of Mrp2 in the biliary excretion of glucuronides. | Journal of pharmaceutical sciences 20080401 |
| Bile salts and glycine as cogerminants for Clostridium difficile spores. | Journal of bacteriology 20080401 |
| Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes. | Hepatology (Baltimore, Md.) 20080401 |
| [Effects of contrast medium on the pancreatic pathology in severe acute pancreatitis experiment with rats]. | Zhonghua yi xue za zhi 20080325 |
| Sensitivity of Haloquadratum and Salinibacter to antibiotics and other inhibitors: implications for the assessment of the contribution of Archaea and Bacteria to heterotrophic activities in hypersaline environments. | FEMS microbiology ecology 20080301 |
| Acute pancreatitis severity is exacerbated by intestinal ischemia-reperfusion conditioned mesenteric lymph. | Surgery 20080301 |
| Taurocholate-induced pancreatitis: a model of severe necrotizing pancreatitis in mice. | Pancreas 20080301 |
| Pharmacokinetic and pharmacodynamic properties of biapenem, a carbapenem antibiotic, in rat experimental model of severe acute pancreatitis. | Pancreas 20080301 |
| The influence of sodium hyaluronate, L-leucine and sodium taurocholate on the nebulization of aqueous betamethasone-17-valerate suspensions. | AAPS PharmSciTech 20080301 |
| Hepatocyte growth factor increases uptake of estradiol 17beta-D-glucuronide and Oatp1 protein level in rat hepatocytes. | European journal of pharmacology 20080202 |
| Effects of resveratrol on calcium regulation in rats with severe acute pancreatitis. | European journal of pharmacology 20080202 |
| The role of NF-kappaB activation in the pathogenesis of acute pancreatitis. | Gut 20080201 |
| Non-synonymous polymorphisms in the human SLCO1B1 gene: an in vitro analysis of SNP c.1929A>C. | Molecular genetics and genomics : MGG 20080201 |
| Modulation of ileal bile acid transporter (ASBT) activity by depletion of plasma membrane cholesterol: association with lipid rafts. | American journal of physiology. Gastrointestinal and liver physiology 20080201 |
| Establishment of an infected necrotizing pancreatitis model by retrograde pancreatic duct injection of sodium taurocholate and E. coli in rats. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080201 |
| Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells. | American journal of physiology. Gastrointestinal and liver physiology 20080101 |
| Solubilization of sphingomyelin vesicles by addition of a bile salt. | Chemistry and physics of lipids 20080101 |
| Activation of MUC1 mucin expression by bile acids in human esophageal adenocarcinomatous cells and tissues is mediated by the phosphatidylinositol 3-kinase. | Surgery 20080101 |
| Obesity alters cytokine gene expression and promotes liver injury in rats with acute pancreatitis. | Obesity (Silver Spring, Md.) 20080101 |
| Dexamethasone affects inflammation but not trypsinogen activation in experimental acute pancreatitis. | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20080101 |
| Methylene blue improves hemodynamic shock but increases lipoperoxidation in severe acute pancreatitis pig model. | Acta cirurgica brasileira 20080101 |
| Deoxycholic acid induces the overexpression of intestinal mucin, MUC2, via NF-kB signaling pathway in human esophageal adenocarcinoma cells. | BMC cancer 20080101 |
| Combination of allopurinol and hyperbaric oxygen therapy: a new treatment in experimental acute necrotizing pancreatitis? | World journal of gastroenterology 20071214 |
| Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanisms. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071201 |
| A mouse model of acute biliary pancreatitis induced by retrograde pancreatic duct infusion of Na-taurocholate. | Gut 20071101 |
| Thymosin alpha 1 improves severe acute pancreatitis in rats via regulation of peripheral T cell number and cytokine serum level. | Journal of gastroenterology and hepatology 20071101 |
| Preferential increase of extracellular matrix expression relative to transforming growth factor beta1 in the pancreas during the early stage of acute hemorrhagic pancreatitis in rats. | Pancreas 20071101 |
| Acinar cell membrane disruption is an early event in experimental acute pancreatitis in rats. | Pancreas 20071101 |
| Evaluation of the effects of noniodinized and iodinized ionic contrast media and gadoteric acid in acute necrotizing pancreatitis: experimental study in rabbits. | Pancreas 20071101 |
| Adaptation of Cryptosporidium oocysts to different excystation conditions. | Parasitology 20071001 |
| Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver. | Liver international : official journal of the International Association for the Study of the Liver 20071001 |
| The therapeutic effect of oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine in rodents with acute necrotizing pancreatitis and its mechanism. | Pancreas 20071001 |
| Prophylactic effect of lafutidine against the adverse reaction induced in rat stomach by repeated administration of 5-fluorouracil. | Inflammopharmacology 20071001 |
| Preparation method of an ideal model of multiple organ injury of rat with severe acute pancreatitis. | World journal of gastroenterology 20070914 |
| Histopathological sequential changes in sodium taurocholate-induced acute pancreatitis. | JOP : Journal of the pancreas 20070907 |
| Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070901 |
| Absorptive profile of chlorogenic acid in rats. | Die Pharmazie 20070901 |
| Involvement of carrier-mediated transport system in uptake of tetrodotoxin into liver tissue slices of puffer fish Takifugu rubripes. | Toxicon : official journal of the International Society on Toxinology 20070801 |
| Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. | Drug metabolism and disposition: the biological fate of chemicals 20070801 |
| Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action. | The Journal of pharmacology and experimental therapeutics 20070801 |
| Effects of Ala substitution for conserved Cys residues in mouse ileal and hepatic Na+-dependent bile acid transporters. | Bioscience, biotechnology, and biochemistry 20070801 |
| Absorption study of deoxycholic acid-heparin conjugate as a new form of oral anti-coagulant. | Journal of controlled release : official journal of the Controlled Release Society 20070716 |
| Adaptive response to increased bile acids: induction of MDR1 gene expression and P-glycoprotein activity in renal epithelial cells. | Pflugers Archiv : European journal of physiology 20070701 |
| Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport. | American journal of physiology. Gastrointestinal and liver physiology 20070701 |
| Intestinal bile salt absorption in Atp8b1 deficient mice. | Journal of hepatology 20070701 |
| Taurocholic acid feeding prevents tumor necrosis factor-alpha-induced damage of cholangiocytes by a PI3K-mediated pathway. | Experimental biology and medicine (Maywood, N.J.) 20070701 |
| Cytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal application. | International journal of pharmaceutics 20070607 |
| Protein-protein interactions and membrane localization of the human organic solute transporter. | American journal of physiology. Gastrointestinal and liver physiology 20070601 |
| Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity. | The Journal of pharmacology and experimental therapeutics 20070601 |
| 4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps. | Hepatology (Baltimore, Md.) 20070601 |
| Effect of early and late antibiotic treatment in experimental acute pancreatitis in rats. | Langenbeck's archives of surgery 20070501 |
| Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver. | Liver international : official journal of the International Association for the Study of the Liver 20070501 |
| Pioglitazone attenuates the severity of sodium taurocholate-induced severe acute pancreatitis. | World journal of gastroenterology 20070407 |
| Involvement of bile salt export pump in flutamide-induced cholestatic hepatitis. | Biological & pharmaceutical bulletin 20070401 |
| [Role of cholesterol phospholipid cholic acid and mucoprotein in the crystallization of gallbladder stone]. | Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20070401 |
| Novel cationic and neutral glycocholic acid and polyamine conjugates able to inhibit transporters involved in hepatic and intestinal bile acid uptake. | Bioorganic & medicinal chemistry 20070315 |
| Linuron and carbaryl differentially impair baseline amino acid and bile salt olfactory responses in three salmonids. | Toxicology 20070307 |
| Dietary nitrate increases gastric mucosal blood flow and mucosal defense. | American journal of physiology. Gastrointestinal and liver physiology 20070301 |
| Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells. | American journal of physiology. Gastrointestinal and liver physiology 20070301 |
| In vitro-in vivo correlation of hepatobiliary drug clearance in humans. | Clinical pharmacology and therapeutics 20070301 |
| Taurocholic acid does not induce apoptosis in HCT116 cells regardless of its intracellular concentration. | Bioscience, biotechnology, and biochemistry 20070301 |
| Effect of parenteral and early intrajejunal nutrition on pancreatic digestive enzyme synthesis, storage and discharge in dog models of acute pancreatitis. | World journal of gastroenterology 20070221 |
| Enhancing effect of surfactants on fexofenadine.HCl transport across the human nasal epithelial cell monolayer. | International journal of pharmaceutics 20070207 |
| Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 cells. | The Journal of pharmacology and experimental therapeutics 20070201 |
| Evidence of Oatp and Mdr1 in cryopreserved rat hepatocytes. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070201 |
| Relationship between the apoptosis and notch-1 expression in acute pancreatitis. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20070201 |
| Bias in estimation of transporter kinetic parameters from overexpression systems: Interplay of transporter expression level and substrate affinity. | The Journal of pharmacology and experimental therapeutics 20070101 |
| Effects of bosentan, an endothelin receptor antagonist, on bile salt export pump and multidrug resistance-associated protein 2. | Biopharmaceutics & drug disposition 20070101 |
| Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury. | Pharmacogenetics and genomics 20070101 |
| Acute pancreatitis affects non-parenchymal liver cells by a mechanism dependent on platelet-activating factor. | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20070101 |
| Taurocholate and taurodeoxycholate: gel formation and protonation constants. | Annali di chimica 20070101 |
| Experimental model of severe acute pancreatitis in rabbits. | Acta cirurgica brasileira 20070101 |
| Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity. | Molecular pharmaceutics 20070101 |
| Cloning and expression of SLC10A4, a putative organic anion transport protein. | World journal of gastroenterology 20061114 |
| Dexamethasone mediates protection against acute pancreatitis via upregulation of pancreatitis-associated proteins. | World journal of gastroenterology 20061114 |
| Lipid composition effect on permeability across PAMPA. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20061101 |
| Time course of lung injury in rat acute pancreatitis. | Intensive care medicine 20061101 |
| Molecular determinants in the transport of a bile acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver. | The Journal of pharmacology and experimental therapeutics 20061101 |
| Role of hepatic opioid receptors in the regulation of bile excretion. | Bulletin of experimental biology and medicine 20061101 |
| OATP8/1B3-mediated cotransport of bile acids and glutathione: an export pathway for organic anions from hepatocytes? | The Journal of biological chemistry 20061013 |
| Importance of bile acids for novel oral absorption system containing polyamines to improve intestinal absorption. | Journal of controlled release : official journal of the Controlled Release Society 20061010 |
| Use of novel cationic bile salts in cholesterol crystallization and solubilization in vitro. | Biochimica et biophysica acta 20061001 |
| Ritonavir, saquinavir, and efavirenz, but not nevirapine, inhibit bile acid transport in human and rat hepatocytes. | The Journal of pharmacology and experimental therapeutics 20060901 |
| The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice. | Journal of lipid research 20060901 |
| Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs. | Drug metabolism and disposition: the biological fate of chemicals 20060901 |
| Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport. | Drug metabolism and disposition: the biological fate of chemicals 20060901 |
| Biorelevant dissolution media as a predictive tool for glyburide a class II drug. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060901 |
| Effects of sodium taurocholate on the absorption of inhaled 99mTc-DTPA. | Pharmaceutical research 20060901 |
| Deoxycholic acid formation in gnotobiotic mice associated with human intestinal bacteria. | Lipids 20060901 |
| Gastroprotective and ulcer-healing activity of oleanolic acid derivatives: in vitro-in vivo relationships. | Life sciences 20060829 |
| Effects of immunosuppressive and immunostimulative treatment on pancreatic injury and mortality in severe acute experimental pancreatitis. | Pancreas 20060801 |
| Inhibition of cyclooxygenase-2 in experimental severe acute pancreatitis. | Clinics (Sao Paulo, Brazil) 20060801 |
| Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis. | World journal of gastroenterology 20060728 |
| Organic anion transporting polypeptide-C mediates arsenic uptake in HEK-293 cells. | Journal of biomedical science 20060701 |
| Interaction of native bile acids with human apical sodium-dependent bile acid transporter (hASBT): influence of steroidal hydroxylation pattern and C-24 conjugation. | Pharmaceutical research 20060701 |
| Pineal hormone melatonin: solubilization studies in model aqueous gastrointestinal environments. | Current drug delivery 20060701 |
| The stability of insulin in solid formulations containing melezitose and starch. Effects of processing and excipients. | Drug development and industrial pharmacy 20060701 |
| Identification of functionally relevant residues of the rat ileal apical sodium-dependent bile acid cotransporter. | The Journal of biological chemistry 20060616 |
| Salicylate enhances rat gastric gelatinase activity. | The Journal of surgical research 20060615 |
| Novel non-systemic inhibitor of ileal apical Na+-dependent bile acid transporter reduces serum cholesterol levels in hamsters and monkeys. | European journal of pharmacology 20060606 |
| Captopril, an Angiotensin-converting enzyme inhibitor, attenuates the severity of acute pancreatitis in rats by reducing expression of matrix metalloproteinase 9. | The Tohoku journal of experimental medicine 20060601 |
| Effects of choleretics on bile compositions drained from patients with pigment gallstone. | Chinese journal of integrative medicine 20060601 |
| Single-step analysis of individual conjugated bile acids in human bile using 1H NMR spectroscopy. | Lipids 20060601 |
| Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. | Gastroenterology 20060501 |
| Gastroprotective and ulcer healing effect of ferruginol in mice and rats: assessment of its mechanism of action using in vitro models. | Life sciences 20060418 |
| Bile acids alter the subcellular localization of CNT2 (concentrative nucleoside cotransporter) and increase CNT2-related transport activity in liver parenchymal cells. | The Biochemical journal 20060415 |
| Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides. | Journal of hepatology 20060401 |
| Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption. | European journal of gastroenterology & hepatology 20060401 |
| Improvement of interfacial protein stability by CHAPS. | Biotechnology letters 20060401 |
| Lung-surfactant-meconium interaction: in vitro study in bulk and at the air-solution interface. | Langmuir : the ACS journal of surfaces and colloids 20060328 |
| Design of novel synthetic MTS conjugates of bile acids for site-directed sulfhydryl labeling of cysteine residues in bile acid binding and transporting proteins. | Bioorganic & medicinal chemistry letters 20060315 |
| Novel oral formulation safely improving intestinal absorption of poorly absorbable drugs: utilization of polyamines and bile acids. | Journal of controlled release : official journal of the Controlled Release Society 20060310 |
| Effects of bile acids on biliary epithelial cell proliferation and portal fibroblast activation using rat liver slices. | Laboratory investigation; a journal of technical methods and pathology 20060301 |
| A multi-analytical platform approach to the metabonomic analysis of plasma from normal and Zucker (fa/fa) obese rats. | Molecular bioSystems 20060301 |
| Inhibitory effects of choleretic hydroxyacetophenones on ileal bile acid transport in rats. | Life sciences 20060227 |
| The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis. | Biochemical and biophysical research communications 20060217 |
| Bicarbonate-rich choleresis induced by secretin in normal rat is taurocholate-dependent and involves AE2 anion exchanger. | Hepatology (Baltimore, Md.) 20060201 |
| The novel formulation design of self-emulsifying drug delivery systems (SEDDS) type O/W microemulsion III: the permeation mechanism of a poorly water soluble drug entrapped O/W microemulsion in rat isolated intestinal membrane by the Ussing chamber method. | Drug metabolism and pharmacokinetics 20060201 |
| Development of the isolated dual perfused rat liver model as an improved reperfusion model for transplantation research. | The International journal of artificial organs 20060201 |
| Kinetics and mechanisms of cholesterol esterase inhibition by cardiovascular drugs in vitro. | Indian journal of biochemistry & biophysics 20060201 |
| Overexpression and characterization of a lipase from Bacillus subtilis. | Protein expression and purification 20060101 |
| [Colocalized expression of Fas and Fas-ligand in acute pancreatitis and its correlation with cell apoptosis]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060101 |
| Uptake of ursodeoxycholate and its conjugates by human hepatocytes: role of Na(+)-taurocholate cotransporting polypeptide (NTCP), organic anion transporting polypeptide (OATP) 1B1 (OATP-C), and oatp1B3 (OATP8). | Molecular pharmaceutics 20060101 |
| High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (bile salt export pump) to predict drug-induced intrahepatic cholestasis. | Molecular pharmaceutics 20060101 |
| Hepatobiliary disposition in primary cultures of dog and monkey hepatocytes. | Molecular pharmaceutics 20060101 |
| Efflux mechanism of taurocholate across the rat intestinal basolateral membrane. | Molecular pharmaceutics 20060101 |
| Adsorption of bile acid by chitosan salts prepared with cinnamic acid and analogue compounds. | Journal of biomaterials science. Polymer edition 20060101 |
| The role of adenosine A2a receptors in experimental acute pancreatitis. | Advances in medical sciences 20060101 |
| Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep. | Biochimica et biophysica acta 20051230 |
| Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats. | World journal of gastroenterology 20051221 |
| Rectal and vaginal administration of insulin-chitosan formulations: an experimental study in rabbits. | Journal of drug targeting 20051201 |
| Deposition of insulin powders for inhalation in vitro and pharmacodynamic evaluation of absorption promoters in rats. | Yao xue xue bao = Acta pharmaceutica Sinica 20051201 |
| Effect of IL-4 on altered expression of complement activation regulators in rat pancreatic cells during severe acute pancreatitis. | World journal of gastroenterology 20051121 |
| Activation of CFTR by ASBT-mediated bile salt absorption. | American journal of physiology. Gastrointestinal and liver physiology 20051101 |
| Synthesis of phospholipid-conjugated bile salts and interaction of bile salt-coated liposomes with cultured hepatocytes. | Journal of lipid research 20051101 |
| Uptake of bilirubin into HepG2 cells assayed by thermal lens spectroscopy. Function of bilitranslocase. | The FEBS journal 20051101 |
| The cannabinoid 1 receptor antagonist, AM251, prolongs the survival of rats with severe acute pancreatitis. | The Tohoku journal of experimental medicine 20051001 |
| Dephosphorylation of Ser-226 facilitates plasma membrane retention of Ntcp. | The Journal of biological chemistry 20050930 |
| Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice. | Biochemistry 20050920 |
| Discovery of potent, nonsystemic apical sodium-codependent bile acid transporter inhibitors (Part 1). | Journal of medicinal chemistry 20050908 |
| Discovery of potent, nonsystemic apical sodium-codependent bile acid transporter inhibitors (Part 2). | Journal of medicinal chemistry 20050908 |
| Morphological and electrophysiological examination of olfactory sensory neurons during the early developmental prolarval stage of the sea lamprey Petromyzon marinus L. | Journal of neurocytology 20050901 |
| Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. | The Journal of pharmacology and experimental therapeutics 20050801 |
| Development of stably transfected monolayer overexpressing the human apical sodium-dependent bile acid transporter (hASBT). | Pharmaceutical research 20050801 |
| Effect of the ulcerogenic agents ethanol, acetylsalicylic acid and taurocholate on actin cytoskeleton and cell motility in cultured rat gastric mucosal cells. | World journal of gastroenterology 20050714 |
| Biliary excretion of taurocholate, organic anions and vinblastine in rats with alpha-naphthylisothiocyanate-induced cholestasis. | Journal of gastroenterology and hepatology 20050701 |
| Study of energy transfer from 7-amino coumarin donors to the rhodamine 6G acceptor in lecithin vesicles and sodium taurocholate-lecithin mixed aggregates. | The journal of physical chemistry. B 20050623 |
| Gender differences in renal tubular taurocholate transport. | Naunyn-Schmiedeberg's archives of pharmacology 20050601 |
| Reply to the comment on 'Two-dimensional NMR study on the structures of micelles of sodium taurocholate'. | The journal of physical chemistry. B 20050519 |
| Cholesterol modulates human intestinal sodium-dependent bile acid transporter. | American journal of physiology. Gastrointestinal and liver physiology 20050501 |
| Hepatic pharmacokinetics of taurocholate in the normal and cholestatic rat liver. | British journal of pharmacology 20050501 |
| mRNA for pancreatic uncoupling protein 2 increases in two models of acute experimental pancreatitis in rats and mice. | Cell and tissue research 20050501 |
| Secretin activation of the apical Na+-dependent bile acid transporter is associated with cholehepatic shunting in rats. | Hepatology (Baltimore, Md.) 20050501 |
| Mild hypothermia protects against sodium taurocholate (NaTc)-induced acute pancreatitis in rats with adverse effects on serum cytokines. | Pancreas 20050501 |
| Biliary excretion of olmesartan, an anigotensin II receptor antagonist, in the rat. | Journal of gastroenterology and hepatology 20050501 |
| Nasal drug delivery of sumatriptan succinate. | Die Pharmazie 20050501 |
| Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. | Drug metabolism and disposition: the biological fate of chemicals 20050401 |
| Therapeutic effects and possible mechanisms of a snake venom preparation in the fibrotic rat liver. | Digestive diseases and sciences 20050401 |
| Bile-induced laryngitis: is there a basis in evidence? | The Annals of otology, rhinology, and laryngology 20050301 |
| Effects of dietary taurocholate, fat and protein on the storage and metabolism of dietary beta-carotene and alpha-tocopherol in ferrets. | International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20050301 |
| The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter. | The Journal of biological chemistry 20050225 |
| Xenobiotics inhibit hepatic uptake and biliary excretion of taurocholate in rat hepatocytes. | Toxicological sciences : an official journal of the Society of Toxicology 20050201 |
| Extrinsic denervation alters postprandial absorption of glucose and glutamine in the ileum: implications for small bowel transplantation. | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20050201 |
| Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model. | The Journal of pharmacy and pharmacology 20050201 |
| Effect of resveratrol on activation of nuclear factor kappa-B and inflammatory factors in rat model of acute pancreatitis. | World journal of gastroenterology 20050128 |
| Pituitary adenylate cyclase activating-peptide and its receptor antagonists in development of acute pancreatitis in rats. | World journal of gastroenterology 20050128 |
| Regulation of taurocholate transport in freshly isolated proximal tubular cells of the rat kidney by protein kinases. | Nephron. Physiology 20050101 |
| Transport of prostaglandin E1 across the blood-brain barrier in rats. | The Journal of pharmacy and pharmacology 20050101 |
| Is there a role of taurine bromamine in inflammation? Interactive effects with nitrite and hydrogen peroxide. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050101 |
| Pathologic alterations detected in acute pancreatitis induced by sodium taurocholate in rats and therapeutic effects of curcumin, ciprofloxacin and metronidazole combination. | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20050101 |
| The effect of activated protein C on experimental acute necrotizing pancreatitis. | Critical care (London, England) 20050101 |
| Involvement of multiple transporters in the efflux of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors across the blood-brain barrier. | The Journal of pharmacology and experimental therapeutics 20041201 |
| Oxygen in the alveolar air space mediates lung inflammation in acute pancreatitis. | Free radical biology & medicine 20041115 |
| The effect of various liposome formulations on insulin penetration across Caco-2 cell monolayer. | Life sciences 20041022 |
| Tumor necrosis factor alpha antibody prevents brain damage of rats with acute necrotizing pancreatitis. | World journal of gastroenterology 20041001 |
| Induction of cholestasis in the perfused rat liver by 2-aminoethyl diphenylborate, an inhibitor of the hepatocyte plasma membrane Ca2+ channels. | Journal of gastroenterology and hepatology 20041001 |
| Biliary excretion of bile acids and organic anions in rats with dichloroethylene-induced bile canalicular injury. | Journal of gastroenterology 20041001 |
| Hepatic clearance and drug metabolism using isolated perfused rat liver. | Current protocols in pharmacology 20041001 |
| Effects of colchicine on the maximum biliary excretion of cholephilic compounds in rats. | Journal of gastroenterology and hepatology 20040901 |
| Regulation of bile acid synthesis under reconstructed enterohepatic circulation in rats. | Steroids 20040901 |
| Comparison of Cryptosporidium parvum development in various cell lines for screening in vitro drug testing. | The Southeast Asian journal of tropical medicine and public health 20040901 |
| Commercially available chemicals that mimic a deposit feeder's (Arenicola marina) digestive solubilization of lipids. | Environmental science & technology 20040815 |
| Involvement of mast cells in basal and neurotensin-induced intestinal absorption of taurocholate in rats. | American journal of physiology. Gastrointestinal and liver physiology 20040801 |
| Connexin 26-mediated gap junctional intercellular communication suppresses paracellular permeability of human intestinal epithelial cell monolayers. | Experimental cell research 20040801 |
| Importance of cytokines, nitric oxide, and apoptosis in the pathological process of necrotizing pancreatitis in rats. | Pancreas 20040801 |
| Comparison of the arrhythmogenic effects of tauro- and glycoconjugates of cholic acid in an in vitro study of rat cardiomyocytes. | BJOG : an international journal of obstetrics and gynaecology 20040801 |
| Chemotactic response of Helicobacter pylori to human plasma and bile. | Journal of medical microbiology 20040801 |
| Insertion and partition of sodium taurocholate into egg phosphatidylcholine vesicles. | Pharmaceutical research 20040801 |
| Influence of PMN leukocyte-mediated pancreatic damage on the systemic immune response in severe acute pancreatitis in rats. | Digestive diseases and sciences 20040801 |
| Effects of octreotide on acute necrotizing pancreatitis in rabbits. | World journal of gastroenterology 20040715 |
| Taurocholate transport by hepatic and intestinal bile acid transporters is independent of FIC1 overexpression in Madin-Darby canine kidney cells. | Journal of gastroenterology and hepatology 20040701 |
| The role of the glucocorticoid-dependent mechanism in the progression of sodium taurocholate-induced acute pancreatitis in the rat. | Pancreas 20040701 |
| Identification of phalloidin uptake systems of rat and human liver. | Biochimica et biophysica acta 20040701 |
| Effects of secretagogues and bile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating DeltaPsim. | The Journal of biological chemistry 20040625 |
| Carboxyl ester lipase cofractionates with scavenger receptor BI in hepatocyte lipid rafts and enhances selective uptake and hydrolysis of cholesteryl esters from HDL3. | The Journal of biological chemistry 20040625 |
| Endothelin receptor antagonists are not beneficial in the therapy of acute experimental pancreatitis. | Langenbeck's archives of surgery 20040601 |
| Differential expression of cholangiocyte and ileal bile acid transporters following bile acid supplementation and depletion. | World journal of gastroenterology 20040515 |
| Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes. | The Journal of biological chemistry 20040514 |
| Lack of biliary lipid excretion in the little skate, Raja erinacea, indicates the absence of functional Mdr2, Abcg5, and Abcg8 transporters. | American journal of physiology. Gastrointestinal and liver physiology 20040501 |
| Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice. | American journal of physiology. Renal physiology 20040501 |
| Absorption of the cholic acid-conjugated peptide hormone cholylsecretin from the rat ileum in vivo. | Acta physiologica Scandinavica 20040501 |
| Bile salts affect epithelial restitution. | Journal of the American College of Surgeons 20040501 |
| A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion. | Human molecular genetics 20040415 |
| Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers. | International journal of pharmaceutics 20040415 |
| Ontogenetic development of rat intestinal bile acid transport requires thyroxine but not corticosterone. | Pediatric research 20040401 |
| Biliary excretion of azelnidipine, a calcium antagonist, in rats. | Journal of gastroenterology and hepatology 20040401 |
| Absorption of taurocholic acid by the ileum of normal and transgenic DeltaF508 cystic fibrosis mice. | The Journal of pharmacy and pharmacology 20040401 |
| Dissolution media simulating the intralumenal composition of the small intestine: physiological issues and practical aspects. | The Journal of pharmacy and pharmacology 20040401 |
| Ca2+-dependent protein kinase C isoforms induce cholestasis in rat liver. | The Journal of biological chemistry 20040312 |
| Molecular cloning and functional characterization of the bovine (Bos taurus) organic anion transporting polypeptide Oatp1a2 (Slco1a2). | Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20040301 |
| Beneficial effect of iloprost on the course of acute taurocholate pancreatitis in rats and its limitation by antecedent acute ethanol intake. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20040301 |
| Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition. | The Journal of biological chemistry 20040220 |
| Excluded volume effect of rat intestinal mucin on taurocholate/phosphatidylcholine mixed micelles. | Journal of colloid and interface science 20040215 |
| Surfactant-facilitated crystallization of dihydrate carbamazepine during dissolution of anhydrous polymorph. | Journal of pharmaceutical sciences 20040201 |
| Alteration of the enterohepatic recirculation of bile acids in rats after exposure to ionizing radiation. | Canadian journal of physiology and pharmacology 20040201 |
| A progressive familial intrahepatic cholestasis type 2 mutation causes an unstable, temperature-sensitive bile salt export pump. | Journal of hepatology 20040101 |
| The effect of combination therapy of hyperbaric oxygen, meropenem, and selective nitric oxide synthase inhibitor in experimental acute pancreatitis. | Pancreas 20040101 |
| Infliximab: a new therapeutic agent in acute pancreatitis? | Pancreas 20040101 |
| Mobilization of xanthine oxidase from the gastrointestinal tract in acute pancreatitis. | BMC gastroenterology 20040101 |
| Beneficial effects of N-acetylcysteine on sodium taurocholate-induced pancreatitis in rats. | Journal of gastroenterology 20040101 |
| Transepithelial electrical resistance is not a reliable measurement of the Caco-2 monolayer integrity in Transwell. | Drug delivery 20040101 |
| Colonoscopy and SeHCAT for investigation of chronic diarrhea. | Digestion 20040101 |
| Mechanism of acute pancreatitis exacerbation by enteral bile-pancreatic juice exclusion. | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20040101 |
| [Concentration changes of amylase in vitreous humor of acute pancreatitis associated with different postmortem interval in rabbits]. | Fa yi xue za zhi 20040101 |
| Inhibition of apolipoprotein B secretion by taurocholate is controlled by the N-terminal end of the protein in rat hepatoma McArdle-RH7777 cells. | Biochimica et biophysica acta 20031230 |
| Bile salts regulate intestinal epithelial cell migration by nuclear factor-kappa B-induced expression of transforming growth factor-beta. | Journal of the American College of Surgeons 20031201 |
| Unique inhibition of bile salt-induced apoptosis by lecithins and cytoprotective bile salts in immortalized mouse cholangiocytes. | Digestive diseases and sciences 20031201 |
| Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake. | American journal of physiology. Gastrointestinal and liver physiology 20031101 |
| Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats. | Toxicological sciences : an official journal of the Society of Toxicology 20031101 |
| Effect of mdr2 mutation with combined tandem disruption of canalicular glycoprotein transporters by cyclosporine A on bile formation in mice. | Pharmacological research 20031101 |
| Cyclooxygenase isozymes involved in adaptive functional responses in rat stomach after barrier disruption. | The Journal of pharmacology and experimental therapeutics 20031101 |
| Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins. | Naunyn-Schmiedeberg's archives of pharmacology 20031101 |
| Role of bile in intestinal barrier function and its inhibitory effect on bacterial translocation in obstructive jaundice in rats. | The Journal of surgical research 20031101 |
| Hepatic canalicular membrane transport of bile salt in C57L/J and AKR/J mice: implications for cholesterol gallstone formation. | The Journal of membrane biology 20031101 |
| In vitro system to evaluate oral absorption of poorly water-soluble drugs: simultaneous analysis on dissolution and permeation of drugs. | Pharmaceutical research 20031001 |
| The endothelin-1 receptor antagonists ameliorate histology and ultrastructural alterations in the pancreas and decrease trypsinogen activation in severe taurocholate pancreatitis in rats. | International journal of experimental pathology 20031001 |
| Effect of maternal obstructive cholestasis during pregnancy on the biliary transport of horseradish peroxidase in the rat offspring. | Clinical science (London, England : 1979) 20030901 |
| Intestinal absorption of the bile acid analogue 75Se-homocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration. | Gut 20030901 |
| The effect of endothelin-1 receptor antagonists in acute experimental pancreatitis in the rats. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20030901 |
| Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3. | Biochemistry 20030826 |
| Mechanisms by which cAMP increases bile acid secretion in rat liver and canalicular membrane vesicles. | American journal of physiology. Gastrointestinal and liver physiology 20030801 |
| N-glycosylation controls functional activity of Oatp1, an organic anion transporter. | American journal of physiology. Gastrointestinal and liver physiology 20030801 |
| Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. | Hepatology (Baltimore, Md.) 20030801 |
| Experimental model of acute pancreatitis in Wistar rat: glucocorticoid treatment profile. | Digestive diseases and sciences 20030801 |
| Bile acid malabsorption in patients with chronic diarrhoea: clinical value of SeHCAT test. | Scandinavian journal of gastroenterology 20030801 |
| Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. | The Journal of biological chemistry 20030725 |
| Preventive effect of hydrotalcite on gastric mucosal injury in rats induced by taurocholate. | World journal of gastroenterology 20030715 |
| Identification and characterization of novel rat and human gonad-specific organic anion transporters. | Molecular endocrinology (Baltimore, Md.) 20030701 |
| ETA and ETB receptor function in pancreatitis-associated microcirculatory failure, inflammation, and parenchymal injury. | American journal of physiology. Gastrointestinal and liver physiology 20030701 |
| Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator. | Physiological genomics 20030624 |
| Inhibition of cholesterol crystallization under bilirubin deconjugation: partial characterization of mechanisms whereby infected bile accelerates pigment stone formation. | Biochimica et biophysica acta 20030610 |
| Kinetic characterization of carrier-mediated transport systems for D-glucose and taurocholate in the everted sacs of the rat colon. | Biological & pharmaceutical bulletin 20030601 |
| Selective binding of steroids by 2,2'-biquinoline-4,4'-dicarboxamide-bridged bis(beta-cyclodextrin): fluorescence enhancement by guest inclusion. | The Journal of organic chemistry 20030502 |
| Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct-ligated rats. | American journal of physiology. Gastrointestinal and liver physiology 20030501 |
| The role of inducible nitric oxide synthase inhibitor, meropenem, and taurine in experimental acute necrotizing pancreatitis. | Pancreas 20030501 |
| The effect of antibiotic and probiotic combination therapy on secondary pancreatic infections and oxidative stress parameters in experimental acute necrotizing pancreatitis. | Pancreas 20030501 |
| Dexamethasone and ursodeoxycholic acid protect against the arrhythmogenic effect of taurocholate in an in vitro study of rat cardiomyocytes. | BJOG : an international journal of obstetrics and gynaecology 20030501 |
| Fatty acid synthesizing enzymes intrinsic to myelin. | Brain research. Molecular brain research 20030410 |
| Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient. | American journal of physiology. Renal physiology 20030401 |
| Retention of transporter activities in cryopreserved, isolated rat hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20030401 |
| Multiple alterations of canalicular membrane transport activities in rats with CCl(4)-induced hepatic injury. | Drug metabolism and disposition: the biological fate of chemicals 20030401 |
| Expression of survivin after acute necrohemorrhagic pancreatitis in rats. | Pancreas 20030301 |
| Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis. | Gastroenterology 20030301 |
| Transport of taurocholate by mutants of negatively charged amino acids, cysteines, and threonines of the rat liver sodium-dependent taurocholate cotransporting polypeptide Ntcp. | European journal of biochemistry 20030301 |
| The relative ligand binding preference of the murine ileal lipid binding protein. | Protein expression and purification 20030301 |
| Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion. | Life sciences 20030207 |
| Taurocholate feeding prevents CCl4-induced damage of large cholangiocytes through PI3-kinase-dependent mechanism. | American journal of physiology. Gastrointestinal and liver physiology 20030201 |
| Substitution of Trp1242 of TM17 alters substrate specificity of human multidrug resistance protein 3. | American journal of physiology. Gastrointestinal and liver physiology 20030201 |
| Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. | Proteins 20030201 |
| A systematic examination of the in vitro Ussing chamber and the in situ single-pass perfusion model systems in rat ileum permeation of model solutes. | Journal of pharmaceutical sciences 20030201 |
| Active influx transport is mediated by members of the organic anion transporting polypeptide family in human epidermal keratinocytes. | The Journal of investigative dermatology 20030201 |
| Down-regulation of the Na+/taurocholate cotransporting polypeptide during pregnancy in the rat. | Journal of hepatology 20030201 |
| Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. | Molecular endocrinology (Baltimore, Md.) 20030201 |
| Effect of hepatic artery flow on bile secretory function after cold ischemia. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20030201 |
| Buccal delivery of thiocolchicoside: in vitro and in vivo permeation studies. | International journal of pharmaceutics 20030102 |
| Physiological characteristics of allo-cholic acid. | Journal of lipid research 20030101 |
| Product ion scanning using a Q-q-Q linear ion trap (Q TRAP) mass spectrometer. | Rapid communications in mass spectrometry : RCM 20030101 |
| Effects of octreotide pretreatment in experimental acute pancreatitis. | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20030101 |
| Prostaglandin E receptor EP1 subtype but not prostacyclin IP receptor involved in mucosal blood flow response of mouse stomachs following barrier disruption. | Digestion 20030101 |
| The response of bile secretion and ubiquinone Q10 to hyperglycaemia in sheep. | Polish journal of veterinary sciences 20030101 |
| Regulation of renal tubular bile acid transport in the early phase of an obstructive cholestasis in the rat. | Nephron. Physiology 20030101 |
| Effect of the dimeric bile acid analogue S 0960, a specific inhibitor of the apical sodium-dependent bile salt transporter in the ileum, on the renal handling of taurocholate. | Arzneimittel-Forschung 20030101 |
| CbsT2 from Lactobacillus johnsonii 100-100 is a transport protein of the major facilitator superfamily that facilitates bile acid antiport. | Journal of molecular microbiology and biotechnology 20030101 |
| The role of cholesterol on the pressure sensing ability of kidneys in rats. | Journal of basic and clinical physiology and pharmacology 20030101 |
| Sinusoidal efflux of taurocholate correlates with the hepatic expression level of Mrp3. | Biochemical and biophysical research communications 20021220 |
| Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor. | Biochemistry 20021217 |
| Effect of nitric oxide on the sinusoidal uptake of organic cations and anions by isolated hepatocytes. | Archives of pharmacal research 20021201 |
| Quantitative evaluation of altered hepatic spaces and membrane transport in fibrotic rat liver. | Hepatology (Baltimore, Md.) 20021101 |
| The role of transhepatic bile salt flux in the control of hepatic secretion of triacylglycerol-rich lipoproteins in vivo in rodents. | Biochimica et biophysica acta 20021010 |
| Cholesterol crystallite nucleation in supersaturated model biles from a thermodynamic standpoint. | Biochimica et biophysica acta 20021009 |
| In vitro versus in vivo cellulose microfibrils from plant primary wall synthases: structural differences. | The Journal of biological chemistry 20021004 |
| Human macrophage-mediated biodegradation of polyurethanes: assessment of candidate enzyme activities. | Biomaterials 20021001 |
| Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. | The Journal of pharmacology and experimental therapeutics 20021001 |
| Mechanisms for absorption enhancement of inhaled insulin by sodium taurocholate. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20021001 |
| Cholesterol treatment forever? The first Scandinavian trial of cholesterol supplementation in the cholesterol-synthesis defect Smith-Lemli-Opitz syndrome. | Journal of internal medicine 20021001 |
| Effects of phalloidin on the biliary excretion of cholephilic compounds in rats. | Pharmacology 20020901 |
| Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity. | American journal of physiology. Gastrointestinal and liver physiology 20020901 |
| Protein kinase B/Akt mediates cAMP- and cell swelling-stimulated Na+/taurocholate cotransport and Ntcp translocation. | The Journal of biological chemistry 20020809 |
| Chirality, twist and structures of micellar lyotropic cholesteric liquid crystals in comparison to the properties of chiralic thermotropic phases. | Advances in colloid and interface science 20020805 |
| Gender difference in the urinary excretion of organic anions in rats. | The Journal of pharmacology and experimental therapeutics 20020801 |
| Taurocholate induces changes in rat cardiomyocyte contraction and calcium dynamics. | Clinical science (London, England : 1979) 20020801 |
| Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. | The Journal of biological chemistry 20020726 |
| Different interactions of egg-yolk phosphatidylcholine and sphingomyelin with detergent bile salts. | Biochimica et biophysica acta 20020711 |
| Effects of hydrophobic and hydrophilic bile salt mixtures on cholesterol crystallization in model biles. | Biochimica et biophysica acta 20020711 |
| Incorporation of cholesterol in sphingomyelin- phosphatidylcholine vesicles has profound effects on detergent-induced phase transitions. | Journal of lipid research 20020701 |
| Gastric nitric oxide synthase expression during endotoxemia: implications in mucosal defense in rats. | Gastroenterology 20020701 |
| Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. | Biochemical pharmacology 20020701 |
| Splanchnic and pancreatic tissue perfusion in experimental acute pancreatitis. | Scandinavian journal of gastroenterology 20020701 |
| Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. | Hepatology (Baltimore, Md.) 20020601 |
| Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats. | Gastroenterology 20020601 |
| Effects of high taurocholate load on activities of hepatic alcohol metabolizing enzymes. | Experimental & molecular medicine 20020531 |
| Intraduodenal conjugated bile salts exert negative feedback control on gall bladder emptying in the fasting state without affecting cholecystokinin release or antroduodenal motility. | Gut 20020501 |
| Gastric hyperemic response induced by acid back-diffusion in rat stomachs following barrier disruption -- relation to vanilloid type-1 receptors. | Medical science monitor : international medical journal of experimental and clinical research 20020501 |
| Effect of hydrochloric acid, pepsin, or taurocholate on bioelectric properties of gastric squamous mucosa in horses. | American journal of veterinary research 20020501 |
| Chiral separation of amino acids derivatized with fluoresceine-5isothiocyanate by capillary electrophoresis and laser-induced fluorescence detection using mixed selectors of beta-cyclodextrin and sodium taurocholate. | Journal of chromatography. A 20020426 |
| Dapsone-induced cholestasis and impairment of bile salt output in the rat. | Biochemical pharmacology 20020415 |
| An evolutionarily ancient Oatp: insights into conserved functional domains of these proteins. | American journal of physiology. Gastrointestinal and liver physiology 20020401 |
| An ultraviolet spectrophotometric assay for measuring lipase activity using long-chain triacyglycerols from Aleurites fordii seeds. | Analytical biochemistry 20020401 |
| Quantitation of cholesterol crystallization from supersaturated model bile. | Journal of lipid research 20020401 |
| Levels of thermostable direct hemolysin produced by Vibrio parahaemolyticus O3:K6 and other serovars grown anaerobically with the presence of a bile acid. | Current microbiology 20020401 |
| Gastric ulcerogenic responses following barrier disruption in knockout mice lacking prostaglandin EP1 receptors. | Alimentary pharmacology & therapeutics 20020401 |
| Characteristics of lysophosphatidylcholine in its inhibition of taurine uptake by human intestinal Caco-2 cells. | Bioscience, biotechnology, and biochemistry 20020401 |
| Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats. | Journal of agricultural and food chemistry 20020313 |
| Human interleukin 10 gene therapy decreases the severity and mortality of lethal pancreatitis in rats. | The Journal of surgical research 20020301 |
| Forecasting the oral absorption behavior of poorly soluble weak bases using solubility and dissolution studies in biorelevant media. | Pharmaceutical research 20020301 |
| [Interactions of unconjugated bilirubin with bile acid by rapid solvent partition]. | Taehan Kan Hakhoe chi = The Korean journal of hepatology 20020301 |
| A physicochemical investigation of two phosphatidylcholine/bile salt interfaces: implications for lipase activation. | Biochimica et biophysica acta 20020227 |
| Inhibition of Mrp2- and Ycf1p-mediated transport by reducing agents: evidence for GSH transport on rat Mrp2. | Biochimica et biophysica acta 20020215 |
| Effect of 17 beta-estradiol-D-17 beta-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates. | Drug metabolism and disposition: the biological fate of chemicals 20020201 |
| In vitro determination of active bile acid absorption in small biopsy specimens obtained endoscopically or surgically from the human intestine. | European journal of clinical investigation 20020201 |
| Effects of Cys mutation on taurocholic acid transport by mouse ileal and hepatic sodium-dependent bile acid transporters. | Bioscience, biotechnology, and biochemistry 20020201 |
| Active taurocholic acid flux through hepatoma cells increases the cellular pool of unesterified cholesterol derived from lipoproteins. | Biochimica et biophysica acta 20020130 |
| pH-dependent interaction of fumonisin B1 with cholesterol: physicochemical and molecular modeling studies at the air-water interface. | Journal of agricultural and food chemistry 20020116 |
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| Role of extrinsic innervation in jejunal absorptive adaptation to subtotal small bowel resection: a model of segmental small bowel transplantation. | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20020101 |
| Role of bile acids in lymphocytic colitis. | Hepato-gastroenterology 20020101 |
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| Production of the mycelial phase of Malassezia in vitro. | Medical mycology 20011201 |
| Role of nonesterified fatty acids in necrotizing pancreatitis: an in vivo experimental study in rats. | Pancreas 20011101 |
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| Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes. | Hepatology (Baltimore, Md.) 20011101 |
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| Indirect evidence that intestinal bile salt absorption in rats and hamsters is under positive feedback control. | Zeitschrift fur Gastroenterologie 20011101 |
| Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate. | Toxicology 20011005 |
| Common mechanisms of monoacylglycerol and fatty acid uptake by human intestinal Caco-2 cells. | American journal of physiology. Cell physiology 20011001 |
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| A simple method for measuring of intestinal solute transport in mucosal biopsy specimens. | Digestive diseases and sciences 20010301 |
| Identification of novel hypocholesterolemic peptides derived from bovine milk beta-lactoglobulin. | Biochemical and biophysical research communications 20010216 |
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| Functional and histochemical analysis of MDR3 P-glycoprotein in a tetracycline-controlled gene expression system. | European journal of medical research 20001229 |
| Mrp2 is essential for estradiol-17beta(beta-D-glucuronide)-induced cholestasis in rats. | Hepatology (Baltimore, Md.) 20000701 |
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