200,000+ products from a single source!

sales@angenechem.com

Home > Other Building Blocks > 1447-88-7

1447-88-7

1447-88-7 | 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-

CAS No: 1447-88-7 Catalog No: AG001K12 MDL No:MFCD00143504

Product Description

Catalog Number:
AG001K12
Chemical Name:
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-
CAS Number:
1447-88-7
Molecular Formula:
C16H12O6
Molecular Weight:
300.2629
MDL Number:
MFCD00143504
IUPAC Name:
5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxychromen-4-one
InChI:
InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3
InChI Key:
IHFBPDAQLQOCBX-UHFFFAOYSA-N
SMILES:
COc1c(O)cc2c(c1O)c(=O)cc(o2)c1ccc(cc1)O
UNII:
N7F61604C2
NSC Number:
122415

Properties

Complexity:
454  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
300.063g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
300.266g/mol
Monoisotopic Mass:
300.063g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
96.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.7  

Literature

Title Journal
Hispidulin inhibits adipogenesis in 3T3-L1 adipocytes through PPARγ pathway. Chemico-biological interactions 20180925
Sage weed (Salvia plebeia) extract antagonizes foam cell formation and promotes cholesterol efflux in murine macrophages. International journal of molecular medicine 20121101
Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals. Toxicology and applied pharmacology 20120901
Flavonoids from the Japanese monotypic genus, Nipponanthemum. Natural product communications 20120801
Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L. Fitoterapia 20120701
Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy. European journal of medicinal chemistry 20120601
Antiproliferative, antimicrobial and apoptosis inducing effects of compounds isolated from Inula viscosa. Molecules (Basel, Switzerland) 20120314
Flavonoids from Algerian endemic Centaurea microcarpa and their chemotaxonomical significance. Natural product communications 20111101
An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatoriumperfoliatum. Phytochemistry 20110501
Simultaneous determination of bioactive flavonoids in some selected Korean thistles by high-performance liquid chromatography. Archives of pharmacal research 20110301
Chemical and biological investigation of some Clerodendrum species cultivated in Egypt. Pharmaceutical biology 20110101
Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/mTOR signaling pathway. Cancer science 20110101
The membrane transport of flavonoids from Crossostephium chinense across the Caco-2 monolayer. Biopharmaceutics & drug disposition 20110101
A new hepatoprotective flavone glycoside from the flowers of Onopordum alexandrinum growing in Egypt. Zeitschrift fur Naturforschung. C, Journal of biosciences 20110101
Neuropharmacological activity of Lippia nodiflora Linn. Pharmacognosy research 20110101
Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea). Frontiers in pharmacology 20110101
Is propolis safe as an alternative medicine? Journal of pharmacy & bioallied sciences 20110101
[Chemical constituents of Iris dichotoma]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101201
Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation. Journal of agricultural and food chemistry 20100922
Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK). Journal of agricultural and food chemistry 20100908
Pro-cognitive effects of Cirsium rivulare extracts in rats. Journal of ethnopharmacology 20100527
High-performance liquid chromatographic quantification of flavonoids in Eriocaulaceae species and their antimicrobial activity. Molecules (Basel, Switzerland) 20091116
[Bioactivity guided isolation of alpha-glucosidase inhibitor from whole herbs of Crossostephium chinense]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090901
Determination of flavonoid compounds from Saussurea involucrata by liquid chromatography electrospray ionisation mass spectrometry. Natural product research 20090101
Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita. Journal of ethnopharmacology 20081030
Chemical fingerprint and quantitative analysis of Salvia plebeia R.Br. by high-performance liquid chromatography. Journal of pharmaceutical and biomedical analysis 20080910
QSAR modeling of the interaction of flavonoids with GABA(A) receptor. European journal of medicinal chemistry 20080801
Evaluation of natural antioxidants of Leuzea carthamoides as a result of a screening study of 88 plant extracts from the European Asteraceae and Cichoriaceae. Journal of enzyme inhibition and medicinal chemistry 20080401
Enhanced carnosic acid levels in two rosemary accessions exposed to cold stress conditions. Journal of agricultural and food chemistry 20071003
Trypanocidal and leishmanicidal activities of flavonoids from Argentine medicinal plants. The American journal of tropical medicine and hygiene 20071001
Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents. Phytotherapy research : PTR 20070901
Anti-inflammatory activity of flavonoids from Eupatorium arnottianum. Journal of ethnopharmacology 20070725
Elemanolide sesquiterpenes and eudesmane sesquiterpene glycosides from Centaurea hierapolitana. Phytochemistry 20070301
Methyl jasmonate stimulates jaceosidin and hispidulin production in cell cultures of Saussurea medusa. Applied biochemistry and biotechnology 20060701
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
A comparison between hairy root cultures and wild plants of Saussurea involucrata in phenylpropanoids production. Plant cell reports 20060101
Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds. Molecular nutrition & food research 20060101
Hispidulin: antioxidant properties and effect on mitochondrial energy metabolism. Free radical research 20051201
Flavonoid composition and antimicrobial activity of Cirsium rivulare (Jacq.) All. flowers. Journal of ethnopharmacology 20051114
Two flavonoids from Artemisia herba-alba Asso with in vitro GABAA-benzodiazepine receptor activity. Journal of ethnopharmacology 20050513
Cellular aggregate size as the critical factor for flavonoid production by suspension cultures of Saussurea medusa. Biotechnology letters 20050101
Topical anti-inflammatory activity of flavonoids and a new xanthone from Santolina insularis. Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101
Differentiation of Cirsium japonicum and C. setosum by TLC and HPLC-MS. Phytochemical analysis : PCA 20050101
Free radical scavengers and antioxidants from Baccharis grisebachii. Journal of ethnopharmacology 20041201
Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway. Journal of agricultural and food chemistry 20040811
Flavonoids: some of the wisdom of sage? British journal of pharmacology 20040701
The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. British journal of pharmacology 20040701
Effects of natural flavones and flavonols on the kinase activity of Cdk5. Journal of natural products 20040301
Effects of methanol extract of Cirsium japonicum var. ussuriense and its principle, hispidulin-7-O-neohesperidoside on hepatic alcohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats. Phytotherapy research : PTR 20040101
Determination of phenolic antioxidant compounds produced by calli and cell suspensions of sage (Salvia officinalis L.). Journal of plant physiology 20030901
Antitumor activity of flavones isolated from Artemisia argyi. Planta medica 20030301
Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta medica 20030201
Flavonoid compounds from the flowers of Cirsium rivulare (Jacq.) All. Acta poloniae pharmaceutica 20030101
Flavonoids from the aquatic plant Eriocaulon buergerianum. Phytochemistry 20021001
Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. Biological & pharmaceutical bulletin 20020701
Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites. Journal of ethnopharmacology 20011101
3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors. Journal of medicinal chemistry 20010607
[Compounds from roots of Chirita fimbrisepala Hand.-Mazz]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010201
Interactions of flavonoids and other phytochemicals with adenosine receptors. Journal of medicinal chemistry 19960202
Effects of flavonoids on Naja naja and human recombinant synovial phospholipases A2 and inflammatory responses in mice. Life sciences 19940101

© 2019 Angene International Limited. All rights Reserved.