200,000+ products from a single source!
sales@angenechem.com
CAS No: 143873-72-7 Catalog No: AG001IIW MDL No:
Title | Journal |
---|---|
Pralatrexate : evaluation of clinical efficacy and toxicity in T-cell lymphoma. | Expert opinion on pharmacotherapy 20130301 |
Lack of expression of MTAP in uncommon T-cell lymphomas. | Clinical lymphoma, myeloma & leukemia 20121001 |
Intestinal transport of aminopterin enantiomers in dogs and humans with psoriasis is stereoselective: evidence for a mechanism involving the proton-coupled folate transporter. | The Journal of pharmacology and experimental therapeutics 20120901 |
Pseudoaminopterin syndrome. | American journal of medical genetics. Part A 20120901 |
Pralatrexate is an effective treatment for relapsed or refractory transformed mycosis fungoides: a subgroup efficacy analysis from the PROPEL study. | Clinical lymphoma, myeloma & leukemia 20120801 |
Evaluation of the OSCAR system for the production of monoclonal antibodies by CHO-K1 cells. | International journal of pharmaceutics 20120701 |
Cutaneous T-cell lymphoma's confounding nature. | Journal of the National Cancer Institute 20120606 |
Pralatrexate: a novel synthetic antifolate for relapsed or refractory peripheral T-cell lymphoma and other potential uses. | Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20120601 |
Randomized phase 2b study of pralatrexate versus erlotinib in patients with stage IIIB/IV non-small-cell lung cancer (NSCLC) after failure of prior platinum-based therapy. | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20120601 |
DNA synthesis as a therapeutic target: the first 65 years. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120601 |
Novel synthesis of 8-deaza-5,6,7,8-tetrahydroaminopterin analogues via an aziridine intermediate. | Molecules (Basel, Switzerland) 20120510 |
Identification of an active, well-tolerated dose of pralatrexate in patients with relapsed or refractory cutaneous T-cell lymphoma. | Blood 20120503 |
Clinical development of new formulations of cytotoxics in solid tumors. | Current opinion in oncology 20120501 |
Sidney Farber and the treatment of childhood acute lymphoblastic leukemia with a chemotherapeutic agent. | Pediatric hematology and oncology 20120501 |
Studying mitochondrial Ca(2+) uptake - a revisit. | Molecular and cellular endocrinology 20120428 |
Teratogen update: methotrexate. | Birth defects research. Part A, Clinical and molecular teratology 20120401 |
Selection of monoclonal antibodies against 6-oxo-M(1)dG and their use in an LC-MS/MS assay for the presence of 6-oxo-M(1)dG in vivo. | Chemical research in toxicology 20120220 |
Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus non-structural protein 3. | The Journal of general virology 20120201 |
Anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of CD44R1 expressed on cancer stem cells. | PloS one 20120101 |
Modeling partial monosomy for human chromosome 21q11.2-q21.1 reveals haploinsufficient genes influencing behavior and fat deposition. | PloS one 20120101 |
ChemoImmunoModulation: immune regulation by the antineoplastic chemotherapeutic agents. | Current medicinal chemistry 20120101 |
Elucidating the role of the complement control protein in monkeypox pathogenicity. | PloS one 20120101 |
The use of recombinant pseudotype virus-like particles harbouring inserted target antigen to generate antibodies against cellular marker p16INK4A. | TheScientificWorldJournal 20120101 |
Pralatrexate (Folotyn). | Skinmed 20120101 |
Pralatrexate with vitamin supplementation in patients with previously treated, advanced non-small cell lung cancer: safety and efficacy in a phase 1 trial. | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20111101 |
Rheumatoid arthritis and pregnancy: evolution of disease activity and pathophysiological considerations for drug use. | Rheumatology (Oxford, England) 20111101 |
Membrane-active host defense peptides--challenges and perspectives for the development of novel anticancer drugs. | Chemistry and physics of lipids 20111101 |
Assessment of intracellular methotrexate and methotrexate-polyglutamate metabolite concentrations in erythrocytes by ultrafast matrix-assisted laser desorption/ionization triple quadrupole tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20111030 |
Efficacy and safety of CH-1504, a metabolically stable antifolate, in patients with active rheumatoid arthritis: results of a phase II multicenter randomized study. | The Journal of rheumatology 20110901 |
Evaluation of the pharmacokinetics, preclinical and clinical efficacy of pralatrexate for the treatment of T-cell lymphoma. | Expert opinion on drug metabolism & toxicology 20110901 |
Discontinued drugs 2010: rheumatology, allergy and dermatology, pulmonary. | Expert opinion on investigational drugs 20110901 |
Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways. | The Journal of biological chemistry 20110812 |
The GPR55 agonist lysophosphatidylinositol directly activates intermediate-conductance Ca2+ -activated K+ channels. | Pflugers Archiv : European journal of physiology 20110801 |
An anti-hapten camelid antibody reveals a cryptic binding site with significant energetic contributions from a nonhypervariable loop. | Protein science : a publication of the Protein Society 20110701 |
Hematology: relapsed and refractory PTCL--into the therapeutic abyss. | Nature reviews. Clinical oncology 20110601 |
Technical approaches for mouse models of human disease. | Disease models & mechanisms 20110501 |
Congenital cardiac defects: a possible association of aminopterin syndrome and in utero methotrexate exposure? | Pediatric cardiology 20110401 |
Evaluation of the reproductive and developmental risks of caffeine. | Birth defects research. Part B, Developmental and reproductive toxicology 20110401 |
Pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma: results from the pivotal PROPEL study. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110320 |
Towards personalized medicine - the role of methotrexate. | The Indian journal of medical research 20110301 |
Consensus-phenotype integration of transcriptomic and metabolomic data implies a role for metabolism in the chemosensitivity of tumour cells. | PLoS computational biology 20110301 |
Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation. | Bioorganic & medicinal chemistry letters 20110215 |
Single agent and combination studies of pralatrexate and molecular correlates of sensitivity. | British journal of cancer 20110118 |
The GPR55 agonist lysophosphatidylinositol acts as an intracellular messenger and bidirectionally modulates Ca2+ -activated large-conductance K+ channels in endothelial cells. | Pflugers Archiv : European journal of physiology 20110101 |
Autoantibodies to endothelial cell surface ATP synthase, the endogenous receptor for hsp60, might play a pathogenic role in vasculatides. | PloS one 20110101 |
Identification of a conserved JEV serocomplex B-cell epitope by screening a phage-display peptide library with a mAb generated against West Nile virus capsid protein. | Virology journal 20110101 |
Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate. | Arthritis research & therapy 20110101 |
Identification of two linear B-cell epitopes from West Nile virus NS1 by screening a phage-displayed random peptide library. | BMC microbiology 20110101 |
USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response. | PloS one 20110101 |
A new weapon against an old target. | Arthritis research & therapy 20110101 |
Development of ELISA-based methods to measure the anti-malarial drug chloroquine in plasma and in pharmaceutical formulations. | Malaria journal 20110101 |
Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report. | Journal of medical case reports 20110101 |
Cell fusion in tumor progression: the isolation of cell fusion products by physical methods. | Cancer cell international 20110101 |
Adhesion of bio-functionalized ultrasound microbubbles to endothelial cells by targeting to vascular cell adhesion molecule-1 under shear flow. | International journal of nanomedicine 20110101 |
The classification of mRNA expression levels by the phosphorylation state of RNAPII CTD based on a combined genome-wide approach. | BMC genomics 20110101 |
Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast. | BMC biology 20110101 |
Critical appraisal of pralatrexate in the management of difficult-to-treat peripheral T cell lymphoma. | Therapeutics and clinical risk management 20110101 |
The association of DNA damage response and nucleotide level modulation with the antibacterial mechanism of the anti-folate drug trimethoprim. | BMC genomics 20110101 |
Generation and characterization of rat and mouse monoclonal antibodies specific for MeCP2 and their use in X-inactivation studies. | PloS one 20110101 |
Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases. | PloS one 20110101 |
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
Uncoupling protein 3 adjusts mitochondrial Ca(2+) uptake to high and low Ca(2+) signals. | Cell calcium 20101101 |
Folotyn (pralatrexate injection) for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma: U.S. Food and Drug Administration drug approval summary. | Clinical cancer research : an official journal of the American Association for Cancer Research 20101015 |
Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs. | Aging 20101001 |
Substrate-specific binding and conformational changes involving Ser313 and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis and protein cross-linking. | The Biochemical journal 20100901 |
GPR55-dependent and -independent ion signalling in response to lysophosphatidylinositol in endothelial cells. | British journal of pharmacology 20100901 |
Targeting pancreatic and ovarian carcinomas using the auristatin-based anti-CD70 antibody-drug conjugate SGN-75. | British journal of cancer 20100824 |
Uncoating of human immunodeficiency virus type 1 requires prolyl isomerase Pin1. | The Journal of biological chemistry 20100813 |
CH-1504, a metabolically inert antifolate for the potential treatment of rheumatoid arthritis. | IDrugs : the investigational drugs journal 20100801 |
Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies. | Clinical cancer research : an official journal of the American Association for Cancer Research 20100715 |
Pralatrexate (Folotyn) for peripheral T-cell lymphoma. | The Medical letter on drugs and therapeutics 20100712 |
Pralatrexate: basic understanding and clinical development. | Expert opinion on pharmacotherapy 20100701 |
A proteomics-based translational approach reveals an antifolate resistance inherent in human plasma derived from blood donation. | Journal of proteome research 20100604 |
Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias. | Cancer chemotherapy and pharmacology 20100501 |
Novel agents in development for peripheral T-cell lymphoma. | Seminars in hematology 20100401 |
Hyperglycemia impairs proteasome function by methylglyoxal. | Diabetes 20100301 |
Anticancer agents against malaria: time to revisit? | Trends in parasitology 20100301 |
StatBite: FDA oncology drug product approvals in 2009. | Journal of the National Cancer Institute 20100224 |
Pralatrexate - from bench to bedside. | Drugs of today (Barcelona, Spain : 1998) 20100201 |
A humanized anti-VEGF rabbit monoclonal antibody inhibits angiogenesis and blocks tumor growth in xenograft models. | PloS one 20100101 |
Biology-driven cancer drug development: back to the future. | BMC biology 20100101 |
Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate. | Drug metabolism and pharmacokinetics 20100101 |
Acute, multiple-dose dermal and genetic toxicity of Nu-3: a novel antimicrobial agent. | Journal of biomedicine & biotechnology 20100101 |
Tyrosine phosphorylation of Grb14 by Tie2. | Cell communication and signaling : CCS 20100101 |
Methotrexate: from its introduction to non-oncologic therapeutics to anti-TNF-α. | Clinical and experimental rheumatology 20100101 |
Irradiation-induced up-regulation of HLA-E on macrovascular endothelial cells confers protection against killing by activated natural killer cells. | PloS one 20100101 |
Cancer chemotherapy: targeting folic acid synthesis. | Cancer management and research 20100101 |
Applicability of Generic Assays Based on Liquid Chromatography-Electrospray Mass Spectrometry to Study in vitro Metabolism of 55 Structurally Diverse Compounds. | Frontiers in pharmacology 20100101 |
Pseudoaminopterin syndrome: clinical report with new characteristics. | American journal of medical genetics. Part A 20091201 |
Cancer research: from folate antagonism to molecular targets. | Best practice & research. Clinical haematology 20091201 |
Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study. | PLoS genetics 20091201 |
FDA approves pralatrexate for treatment of rare lymphoma. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20091101 |
Development and characterization of HAT-sensitive Ewing tumour cells for immunotherapy. | Anticancer research 20091101 |
Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers. | Cancer chemotherapy and pharmacology 20091001 |
Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species. | Experimental parasitology 20091001 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
Phase II-I-II study of two different doses and schedules of pralatrexate, a high-affinity substrate for the reduced folate carrier, in patients with relapsed or refractory lymphoma reveals marked activity in T-cell malignancies. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090910 |
GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. | PLoS genetics 20090901 |
A population pharmacokinetic and pharmacodynamic evaluation of pralatrexate in patients with relapsed or refractory non-Hodgkin's or Hodgkin's lymphoma. | Clinical pharmacology and therapeutics 20090801 |
Importance of early splenectomy in patients with hepatosplenic T-cell lymphoma and severe thrombocytopenia. | Annals of surgical oncology 20090701 |
Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions. | Blood 20090618 |
T-cell lymphomas. | Clinical advances in hematology & oncology : H&O 20090601 |
Mouse models of genomic syndromes as tools for understanding the basis of complex traits: an example with the smith-magenis and the potocki-lupski syndromes. | Current genomics 20090601 |
Methotrexate and aminopterin exhibit similar in vitro and in vivo preclinical activity against acute lymphoblastic leukaemia and lymphoma. | British journal of haematology 20090501 |
Protein folding does not prevent the nonclassical export of FGF1 and S100A13. | Biochemical and biophysical research communications 20090410 |
Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs. | Biochemical pharmacology 20090401 |
Pralatrexate, a new hope for aggressive T-cell lymphomas? | Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20090401 |
Neisseria meningitidis Opc invasin binds to the cytoskeletal protein alpha-actinin. | Cellular microbiology 20090301 |
Domain-and species-specific monoclonal antibodies recognize the Von Willebrand Factor-C domain of CCN5. | Journal of cell communication and signaling 20090301 |
Novel 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives as dihydrofolate inhibitor: design, synthesis and antifolate activity. | European journal of medicinal chemistry 20090201 |
Fetal methotrexate/aminopterin syndrome in an adult: a likely case with ectodermal abnormalities. | Clinical dysmorphology 20090101 |
Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia. | Pediatric neurology 20090101 |
Semi-allogeneic vaccines and tumor-induced immune tolerance. | Journal of translational medicine 20090101 |
Identification of ATP synthase beta subunit (ATPB) on the cell surface as a non-small cell lung cancer (NSCLC) associated antigen. | BMC cancer 20090101 |
Biological behaviors and proteomics analysis of hybrid cell line EAhy926 and its parent cell line A549. | Journal of experimental & clinical cancer research : CR 20090101 |
Anti-idiotypic antibodies: a new approach in prion research. | BMC immunology 20090101 |
Isolation and properties of gene-modified mouse bcr-abl-transformed cells expressing various immunostimulatory factors. | Neoplasma 20090101 |
Musings on genome medicine: cancer genetics and the promise of effective treatment. | Genome medicine 20090101 |
Discovery: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria. | Malaria journal 20090101 |
Detailed analysis of X chromosome inactivation in a 49,XXXXX pentasomy. | Molecular cytogenetics 20090101 |
HIV-1 neutralization by monoclonal antibody against conserved region 2 and patterns of epitope exposure on the surface of native viruses. | Journal of immune based therapies and vaccines 20090101 |
Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme. | Molecular neurodegeneration 20090101 |
The roles of platelet GPIIb/IIIa and alphavbeta3 integrins during HeLa cells adhesion, migration, and invasion to monolayer endothelium under static and dynamic shear flow. | Journal of biomedicine & biotechnology 20090101 |
Design and pre-clinical profiling of a Plasmodium falciparum MSP-3 derived component for a multi-valent virosomal malaria vaccine. | Malaria journal 20090101 |
Mizoribine: a new approach in the treatment of renal disease. | Clinical & developmental immunology 20090101 |
Optimizing chemotherapeutic strategies for peripheral T-cell lymphomas. | Clinical lymphoma & myeloma 20081201 |
Novel therapies for cutaneous T-cell lymphomas. | Clinical lymphoma & myeloma 20081201 |
Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo. | Cancer chemotherapy and pharmacology 20081101 |
Plasmodium berghei: lack of antimalarial activity of an analogue of folate precursor, 2,4-diamino-6-hydroxymethylpteridine in a mouse model. | Experimental parasitology 20081101 |
Low-dose methotrexate therapy for intravenous immunoglobulin-resistant Kawasaki disease. | Yonsei medical journal 20081031 |
Novel therapies in peripheral T-cell lymphomas. | Current oncology reports 20080901 |
Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2. | PLoS genetics 20080901 |
Contemporary approaches for modifying the mouse genome. | Physiological genomics 20080801 |
An optimized electrofusion-based protocol for generating virus-specific human monoclonal antibodies. | Journal of immunological methods 20080731 |
Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes. | Molecular microbiology 20080701 |
Pralatrexate, a dihydrofolate reductase inhibitor for the potential treatment of several malignancies. | IDrugs : the investigational drugs journal 20080701 |
[Development of the monoclonal antibody to deoxynivalenol]. | Wei sheng wu xue bao = Acta microbiologica Sinica 20080701 |
Phase 2B trial of aminopterin in multiagent therapy for children with newly diagnosed acute lymphoblastic leukemia. | Cancer chemotherapy and pharmacology 20080601 |
Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer. | Parasitology research 20080501 |
Muscle precursor cells in the developing limbs of two isopods (Crustacea, Peracarida): an immunohistochemical study using a novel monoclonal antibody against myosin heavy chain. | Development genes and evolution 20080501 |
CD4+ CD56+ hematodermic/plasmacytoid dendritic cell tumor with response to pralatrexate. | Journal of the American Academy of Dermatology 20080301 |
Battling the hematological malignancies: the 200 years' war. | The oncologist 20080201 |
Live cell vaccines expressing B7.1, monocyte chemoattractant protein 1 and granulocyte-macrophage colony stimulation factor derived from mouse HPV16-transformed cells. | International journal of oncology 20080101 |
Constitutive overexpression of a novel 21 kDa protein by Hodgkin lymphoma and aggressive non-Hodgkin lymphomas. | Molecular cancer 20080101 |
Two single-center, double-blind, randomized, placebo-controlled, phase I studies to investigate the tolerability and pharmacokinetics of CH-1504, an antifolate, in healthy male subjects. | Clinical therapeutics 20080101 |
[Growth and differentiation of cell hybrids obtained by fusing mouse PCC4azal teratocarcinoma cells and mouse spleen cells under different in vitro culture conditions]. | Ontogenez 20080101 |
[The status of nucleolus organizing regions in hybrids of pluripotent and somatic mouse cells cultured under different conditions]. | Tsitologiia 20080101 |
Resistance of colorectal cancer cells to 5-FUdR and 5-FU caused by Mycoplasma infection. | Anticancer research 20080101 |
Anti-HIV-1 response elicited in rabbits by anti-idiotype monoclonal antibodies mimicking the CD4-binding site. | PloS one 20080101 |
A PP1-binding motif present in BRCA1 plays a role in its DNA repair function. | International journal of biological sciences 20080101 |
Intragenic transcriptional cis-activation of the human immunodeficiency virus 1 does not result in allele-specific inhibition of the endogenous gene. | Retrovirology 20080101 |
T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis. | Arthritis research & therapy 20080101 |
The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. | PloS one 20080101 |
Ir-LBP, an ixodes ricinus tick salivary LTB4-binding lipocalin, interferes with host neutrophil function. | PloS one 20080101 |
Zinc deficiency decreased cell viability both in endothelial EA.hy926 cells and mouse aortic culture ex vivo and its implication for anti-atherosclerosis. | Nutrition research and practice 20080101 |
High-performance liquid chromatography separation of aminopterin-polyglutamates within red blood cells of children treated for acute lymphoblastic leukemia. | Translational research : the journal of laboratory and clinical medicine 20071201 |
A pilot open trial evaluating the efficacy of low-dose aminopterin in the canine homologue of human atopic dermatitis. | The British journal of dermatology 20071101 |
Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma. | British journal of haematology 20071101 |
Aminopterin might be safe in ALL. | The Lancet. Oncology 20071001 |
The oligopeptide (opp) gene cluster of Streptococcus mutans: identification, prevalence, and characterization. | Oral microbiology and immunology 20070801 |
Phase II trial of 10-EDAM in the treatment of metastatic breast cancer. | Cancer chemotherapy and pharmacology 20070601 |
A phase 1 study of pralatrexate in combination with paclitaxel or docetaxel in patients with advanced solid tumors. | Clinical cancer research : an official journal of the American Association for Cancer Research 20070501 |
Phase II trial of pralatrexate (10-propargyl-10-deazaaminopterin, PDX) in patients with unresectable malignant pleural mesothelioma. | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20070401 |
Development of a monoclonal antibody-based co-agglutination test to detect enterotoxigenic Escherichia coli isolated from diarrheic neonatal calves. | Journal of veterinary science 20070301 |
Dihydrofolate reductase as a target for chemotherapy in parasites. | Current pharmaceutical design 20070101 |
Contested cumulations: configurations of cancer treatments through the twentieth century. | Bulletin of the history of medicine 20070101 |
Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA. | Virology journal 20070101 |
Semi-allogeneic vaccine for T-cell lymphoma. | Journal of translational medicine 20070101 |
High level glucose increases mutagenesis in human lymphoblastoid cells. | International journal of biological sciences 20070101 |
Pralatrexate: an emerging new agent with activity in T-cell lymphomas. | Current opinion in oncology 20061101 |
Methotrexate-albumin and aminopterin-albumin effectively prevent experimental acute graft-versus-host disease. | Transplantation 20060827 |
A proposed clinical test for monitoring fluoropyrimidine therapy: detection and stability of thymidylate synthase ternary complexes. | Cancer biology & therapy 20060801 |
Base excision repair of both uracil and oxidatively damaged bases contribute to thymidine deprivation-induced radiosensitization. | International journal of radiation oncology, biology, physics 20060801 |
Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations. | PLoS genetics 20060701 |
Pharmacodynamic properties of methotrexate and Aminotrexate during weekly therapy. | Cancer chemotherapy and pharmacology 20060601 |
A phase I clinical pharmacologic study of pralatrexate in combination with probenecid in adults with advanced solid tumors. | Cancer chemotherapy and pharmacology 20060501 |
Controlled trial of methotrexate versus CH-1504 in the treatment of rheumatoid arthritis. | The Journal of rheumatology 20060501 |
In vivo analysis of Drosophila deoxyribonucleoside kinase function in cell cycle, cell survival and anti-cancer drugs resistance. | Cell cycle (Georgetown, Tex.) 20060401 |
5-amino-4-imidazolecarboxamide riboside potentiates both transport of reduced folates and antifolates by the human reduced folate carrier and their subsequent metabolism. | Cancer research 20060401 |
The schedule-dependent effects of the novel antifolate pralatrexate and gemcitabine are superior to methotrexate and cytarabine in models of human non-Hodgkin's lymphoma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20060201 |
Prodrug forms of N-[(4-deoxy-4-amino-10-methyl)pteroyl]glutamate-gamma-[psiP(O)(OH)]-glutarate, a potent inhibitor of folylpoly-gamma-glutamate synthetase: synthesis and hydrolytic stability. | Journal of medicinal chemistry 20060126 |
Anti-inflammatory and immunosuppressive drugs and reproduction. | Arthritis research & therapy 20060101 |
Human pregnancy safety for agents used to treat rheumatoid arthritis: adequacy of available information and strategies for developing post-marketing data. | Arthritis research & therapy 20060101 |
Methotrexate in rheumatoid arthritis. | Pharmacological reports : PR 20060101 |
Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV. | Retrovirology 20060101 |
Higher plant plastids and cyanobacteria have folate carriers related to those of trypanosomatids. | The Journal of biological chemistry 20051118 |
Phase II trial of oral aminopterin for adults and children with refractory acute leukemia. | Clinical cancer research : an official journal of the American Association for Cancer Research 20051115 |
Calorimetric studies of ligand binding in R67 dihydrofolate reductase. | Biochemistry 20050920 |
Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles. | British journal of cancer 20050822 |
Homocysteine down-regulates cellular glutathione peroxidase (GPx1) by decreasing translation. | The Journal of biological chemistry 20050422 |
Interactions of carboxypeptidase G2 with 6S-leucovorin and 6R-leucovorin in vitro: implications for the application in case of methotrexate intoxications. | Cancer chemotherapy and pharmacology 20050401 |
Bystander effects may modulate ultraviolet A and B radiation-induced delayed mutagenesis. | Radiation research 20050301 |
Bystander effects in UV-induced genomic instability: antioxidants inhibit delayed mutagenesis induced by ultraviolet A and B radiation. | Journal of carcinogenesis 20050101 |
Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B. | BMC physiology 20050101 |
An indirect enzyme-linked immunosorbent assay for rapid and quantitative assessment of Type III virulence phenotypes of Pseudomonas aeruginosa isolates. | Annals of clinical microbiology and antimicrobials 20050101 |
Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues. | Journal of medicinal chemistry 20041230 |
Production and purification of monoclonal and polyclonal antibodies against cholera toxin. | Hybridoma and hybridomics 20040801 |
Determination of the chiral and achiral related substances of methotrexate by cyclodextrin-modified micellar electrokinetic chromatography. | Electrophoresis 20040801 |
Pseudoaminopterin syndrome and trisomy 9. | American journal of medical genetics. Part A 20040715 |
Final results of a phase I and pharmacokinetic study of gamma-methylene-10-deazaaminopterin (MDAM) administered intravenously daily for five consecutive days in patients with solid tumors. | Cancer chemotherapy and pharmacology 20040501 |
Unconventional protein secretion: membrane translocation of FGF-2 does not require protein unfolding. | Journal of cell science 20040401 |
Identification of cross-reactive and restricted epitopes localized on human chorionic gonadotropin beta-subunit by monoclonal antibodies. | Hybridoma and hybridomics 20040401 |
The Drosophila wing differentiation factor vestigial-scalloped is required for cell proliferation and cell survival at the dorso-ventral boundary of the wing imaginal disc. | Cell death and differentiation 20040101 |
Yersinia enterocolitica type III secretion: evidence for the ability to transport proteins that are folded prior to secretion. | BMC microbiology 20040101 |
Methotrexate/misoprostol embryopathy: report of four cases resulting from failed medical abortion. | American journal of medical genetics. Part A 20031115 |
10-propargyl-10-deazaaminopterin: an antifolate with activity in patients with previously treated non-small cell lung cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20030601 |
Activity of a novel anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression. | Leukemia & lymphoma 20030601 |
Further studies on the interaction of nonpolyglutamatable aminopterin analogs with dihydrofolate reductase and the reduced folate carrier as determinants of in vitro antitumor activity. | Biochemical pharmacology 20030501 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20030501 |
Molecular cloning and expression of the dihydrofolate reductase (DHFR) gene from adult buffalo fly (Haematobia irritans exigua): effects of antifolates. | Insect molecular biology 20030401 |
Metabolism of homocysteine-thiolactone in plants. | The Journal of biological chemistry 20030227 |
Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. | International journal of cancer 20030220 |
Recognition of multiple Mycoplasma bovis antigens by monoclonal antibodies. | Hybridoma and hybridomics 20030201 |
Generation and characterization of a mouse monoclonal antibody with specificity similar to staphylococcal protein A (SPA). | Hybridoma and hybridomics 20030201 |
OspA heterogeneity of Borrelia valaisiana confirmed by phenotypic and genotypic analyses. | BMC infectious diseases 20030101 |
Anticancer antifolates: current status and future directions. | Current pharmaceutical design 20030101 |
Aminopterin-human serum albumin conjugate (AP-HSA): uptake and cytotoxic effects in tumor cell lines. | International journal of clinical pharmacology and therapeutics 20021201 |
A novel folate transport activity in human mesothelioma cell lines with high affinity and specificity for the new-generation antifolate, pemetrexed. | Cancer research 20021115 |
SycE allows secretion of YopE-DHFR hybrids by the Yersinia enterocolitica type III Ysc system. | Molecular microbiology 20021101 |
Gammaherpesviruses encode functional dihydrofolate reductase activity. | Biochemical and biophysical research communications 20021004 |
Production of monoclonal and polyclonal antibodies against human alphafetoprotein, a hepatocellular tumor marker. | Hybridoma and hybridomics 20020801 |
Efficacy and tolerability of an aminopterin-albumin conjugate in tumor-bearing rats. | Anti-cancer drugs 20020701 |
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
Synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523). | Journal of medicinal chemistry 20020411 |
Dominant negative knockout of p53 abolishes ErbB2-dependent apoptosis and permits growth acceleration in human breast cancer cells. | British journal of cancer 20020408 |
Gateways to Clinical Trials. | Methods and findings in experimental and clinical pharmacology 20020401 |
Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors. | Biochemistry 20020108 |
Physical mapping of genes in somatic cell radiation hybrids by comparative genomic hybridization to cDNA microarrays. | Genome biology 20020101 |
Phase I trial of edatrexate in advanced breast and other cancers. | Cancer investigation 20020101 |
Multipotentiality of neuronal cells after spontaneous fusion with embryonic stem cells and nuclear reprogramming in vitro. | Cloning and stem cells 20020101 |
Spontaneous reactivation of the inactive X chromosome in mouse embryonal carcinoma cells. | Cytogenetic and genome research 20020101 |
A phase II trial of edatrexate, vinblastine, adriamycin, cisplastin, and filgrastim (EVAC/G-CSF) in patients with non-small-cell carcinoma of the lungs: a North Central Cancer Treatment Group Trial. | American journal of clinical oncology 20011201 |
Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums. | Clinical cancer research : an official journal of the American Association for Cancer Research 20011001 |
Molecular analysis of HPRT1(+) somatic cell hybrids derived from a carrier of an HPRT1 mutation responsible for Lesch-Nyhan syndrome. | American journal of medical genetics 20010915 |
Free energy force field (FEFF) 3D-QSAR analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors. | Journal of computer-aided molecular design 20010901 |
Requirement of de novo protein synthesis for aminopterin-induced apoptosis in a mouse myeloma cell line. | Immunology letters 20010702 |
Phase I and pharmacological study of two schedules of the antifolate edatrexate in combination with cisplatin. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010301 |
Synthesis and antifolate evaluation of the aminopterin analogue with a bicyclo. | European journal of medicinal chemistry 20010301 |
A search for sources of drug resistance by the 4D-QSAR analysis of a set of antimalarial dihydrofolate reductase inhibitors. | Journal of computer-aided molecular design 20010101 |
Syntheses of glycine and L-serine by their interconversion in the posterior silkgland of the silkworm, Bombyx mori. | Amino acids 20010101 |
[Fetal aminopterin syndrome]. | Ryoikibetsu shokogun shirizu 20010101 |
[Pseudoaminopterin syndrome]. | Ryoikibetsu shokogun shirizu 20010101 |
Developmental delay in fetal aminopterin/methotrexate syndrome. | Teratology 19990701 |
Adult and two children with fetal methotrexate syndrome. | Teratology 19980201 |
Phase I trial of edatrexate plus carboplatin in advanced solid tumors: amelioration of dose-limiting mucositis by ice chip cryotherapy. | Investigational new drugs 19980101 |
Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism. | Cancer research 19920415 |
Efficacies of antiherpesvirus nucleosides against two strains of herpes simplex virus type 1 in Vero and human embryo lung fibroblast cells. | Antimicrobial agents and chemotherapy 19880701 |
Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition. | Journal of medicinal chemistry 19880701 |
Activity of sulfa drugs and dihydrofolate reductase inhibitors against Candida albicans. | Experientia 19820415 |
On the mechanism of action of aminopterin. | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19500601 |
© 2019 Angene International Limited. All rights Reserved.