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1436-44-8 | Isoquinoline-1-carboxamide
CAS No: 1436-44-8 Catalog No: AG006U96 MDL No:MFCD00160679
Product Description
Catalog Number:
AG006U96
Chemical Name:
Isoquinoline-1-carboxamide
CAS Number:
1436-44-8
Molecular Formula:
C10H8N2O
Molecular Weight:
172.1833
MDL Number:
MFCD00160679
IUPAC Name:
isoquinoline-1-carboxamide
InChI:
InChI=1S/C10H8N2O/c11-10(13)9-8-4-2-1-3-7(8)5-6-12-9/h1-6H,(H2,11,13)
InChI Key:
YZDXFUGIDTUCDA-UHFFFAOYSA-N
SMILES:
NC(=O)c1nccc2c1cccc2
NSC Number:
115632
Properties
Complexity:
205
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
172.064g/mol
Formal Charge:
0
Heavy Atom Count:
13
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
172.187g/mol
Monoisotopic Mass:
172.064g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
56A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.5
Literature
| Title | Journal |
|---|---|
| Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides. | Frontiers in endocrinology 20120101 |
| Effects and Mechanisms of 3α,5α,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor. | Frontiers in neuroscience 20110101 |
| Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo. | European journal of pharmacology 20100125 |
| Bacterial ortholog of mammalian translocator protein (TSPO) with virulence regulating activity. | PloS one 20090101 |
| Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor. | Bioorganic & medicinal chemistry 20080601 |
| The scale-free dynamics of eukaryotic cells. | PloS one 20080101 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells. | Molecular pharmacology 20060101 |
| High-affinity peripheral benzodiazepine receptor ligand, PK11195, regulates protein phosphorylation in rat brain mitochondria under control of Ca(2+). | Journal of neurochemistry 20050801 |
| Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation: role of ERK, c-Jun and ligand-activated PBR-independent pathways. | Biochemical pharmacology 20040515 |
| In vitro effects of lead ions on peripheral benzodiazepine receptors and adenylyl cyclase activity in the mantle of Mytilus galloprovincialis. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20040201 |
| Upregulation of 'peripheral-type' benzodiazepine receptors in the globus pallidus in a sub-acute rat model of manganese neurotoxicity. | Neuroscience letters 20030925 |
| Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway. | British journal of cancer 20030804 |
| The role of peripheral benzodiazepine receptors (PBRs) in CNS pathophysiology. | Current medicinal chemistry 20020801 |
| The 'peripheral-type' benzodiazepine (omega 3) receptor in hyperammonemic disorders. | Neurochemistry international 20020101 |
| PK11195, an isoquinoline carboxamide ligand of the mitochondrial benzodiazepine receptor, increased drug uptake and facilitated drug-induced apoptosis in human multidrug-resistant leukemia cells in vitro. | Neoplasma 20020101 |
| Structural and functional study of reconstituted peripheral benzodiazepine receptor. | Biochemical and biophysical research communications 20010608 |
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