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Home > Imidazoles > 143249-88-1
143249-88-1 | 1H-Imidazole,2-[(2R)-2-ethyl-2,3-dihydro-2-benzofuranyl]-4,5-dihydro-
CAS No: 143249-88-1 Catalog No: AG007KBF MDL No:
Product Description
Catalog Number:
AG007KBF
Chemical Name:
1H-Imidazole,2-[(2R)-2-ethyl-2,3-dihydro-2-benzofuranyl]-4,5-dihydro-
CAS Number:
143249-88-1
Molecular Formula:
C13H16N2O
Molecular Weight:
216.2789
IUPAC Name:
2-[(2R)-2-ethyl-3H-1-benzofuran-2-yl]-4,5-dihydro-1H-imidazole
InChI:
InChI=1S/C13H16N2O/c1-2-13(12-14-7-8-15-12)9-10-5-3-4-6-11(10)16-13/h3-6H,2,7-9H2,1H3,(H,14,15)/t13-/m1/s1
InChI Key:
RATZLMXRALDSJW-CYBMUJFWSA-N
SMILES:
CC[C@@]1(Cc2c(O1)cccc2)C1=NCCN1
UNII:
F751MO69EV
Properties
Complexity:
302
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
216.126g/mol
Formal Charge:
0
Heavy Atom Count:
16
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
216.284g/mol
Monoisotopic Mass:
216.126g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
33.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.7
Literature
| Title | Journal |
|---|---|
| Reduced tissue levels of noradrenaline are associated with behavioral phenotypes of the TgCRND8 mouse model of Alzheimer's disease. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120701 |
| Noradrenergic control of odor recognition in a nonassociative olfactory learning task in the mouse. | Learning & memory (Cold Spring Harbor, N.Y.) 20071201 |
| The alpha2-adrenoceptor antagonist dexefaroxan enhances hippocampal neurogenesis by increasing the survival and differentiation of new granule cells. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060601 |
| Activation of noradrenergic transmission by alpha2-adrenoceptor antagonists counteracts deafferentation-induced neuronal death and cell proliferation in the adult mouse olfactory bulb. | Experimental neurology 20050801 |
| In vivo upregulation of endogenous NGF in the rat brain by the alpha2-adrenoreceptor antagonist dexefaroxan: potential role in the protection of the basalocortical cholinergic system during neurodegeneration. | Experimental neurology 20041201 |
| Stimulation of postsynaptic alpha1b- and alpha2-adrenergic receptors amplifies dopamine-mediated locomotor activity in both rats and mice. | Synapse (New York, N.Y.) 20031215 |
| Dissimilar pharmacological responses by a new series of imidazoline derivatives at precoupled and ligand-activated alpha 2A-adrenoceptor states: evidence for effector pathway-dependent differential antagonism. | The Journal of pharmacology and experimental therapeutics 20030601 |
| Effects of the alpha 2-adrenoreceptor antagonist dexefaroxan on neurogenesis in the olfactory bulb of the adult rat in vivo: selective protection against neuronal death. | Neuroscience 20030101 |
| Evidence for protean agonism of RX 831003 at alpha 2A-adrenoceptors by co-expression with different G alpha protein subunits. | Neuropharmacology 20020501 |
| Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents. | The Journal of pharmacology and experimental therapeutics 20020401 |
| Protective effects of the alpha 2-adrenoceptor antagonist, dexefaroxan, against degeneration of the basalocortical cholinergic system induced by cortical devascularization in the adult rat. | Neuroscience 20020101 |
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