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142273-20-9 | Indolo[3,2-d][1]benzazepin-6(5H)-one, 9-bromo-7,12-dihydro-
CAS No: 142273-20-9 Catalog No: AG001I3S MDL No:MFCD02683595
Product Description
Catalog Number:
AG001I3S
Chemical Name:
Indolo[3,2-d][1]benzazepin-6(5H)-one, 9-bromo-7,12-dihydro-
CAS Number:
142273-20-9
Molecular Formula:
C16H11BrN2O
Molecular Weight:
327.1753
MDL Number:
MFCD02683595
IUPAC Name:
9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one
InChI:
InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
InChI Key:
QQUXFYAWXPMDOE-UHFFFAOYSA-N
SMILES:
O=C1Nc2ccccc2c2c(C1)c1cc(Br)ccc1[nH]2
NSC Number:
664704
Properties
Complexity:
402
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
326.005g/mol
Formal Charge:
0
Heavy Atom Count:
20
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
327.181g/mol
Monoisotopic Mass:
326.005g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
44.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.3
Literature
| Title | Journal |
|---|---|
| Identification of compounds that modulate retinol signaling using a cell-based qHTS assay. | Toxicology in vitro : an international journal published in association with BIBRA 20160401 |
| A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. | Experimental hematology 20150501 |
| Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions. | Toxicology and applied pharmacology 20150415 |
| Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts. | Cardiovascular research 20150101 |
| A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. | Cell stem cell 20130606 |
| A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. | The Biochemical journal 20130415 |
| Polycyclic aromatic hydrocarbons and dibutyl phthalate disrupt dorsal-ventral axis determination via the Wnt/β-catenin signaling pathway in zebrafish embryos. | Aquatic toxicology (Amsterdam, Netherlands) 20121115 |
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. | Bioorganic & medicinal chemistry 20121115 |
| Synthesis and evaluation of novel anti-proliferative pyrroloazepinone and indoloazepinone oximes derived from the marine natural product hymenialdisine. | European journal of medicinal chemistry 20121001 |
| Inhibition of Gsk3β activity improves β-cell function in c-KitWv/+ male mice. | Laboratory investigation; a journal of technical methods and pathology 20120401 |
| Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. | Nature biotechnology 20111101 |
| Neuroprotective effects of the beta-catenin stabilization in an oxygen- and glucose-deprived human neural progenitor cell culture system. | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20110801 |
| Akt/GSK3β signaling is involved in fipronil-induced apoptotic cell death of human neuroblastoma SH-SY5Y cells. | Toxicology letters 20110425 |
| Proliferative and androgenic effects of indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic concentrations. | Chemico-biological interactions 20110201 |
| Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. | Bioorganic & medicinal chemistry 20100915 |
| Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay. | European journal of medicinal chemistry 20100901 |
| Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation. | Journal of medicinal chemistry 20100325 |
| Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH). | European journal of medicinal chemistry 20100101 |
| Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. | AIDS research and therapy 20100101 |
| Novel screening method for potential skin-whitening compounds by a luciferase reporter assay. | Bioscience, biotechnology, and biochemistry 20100101 |
| Regulation of serotonin 1B receptor by glycogen synthase kinase-3. | Molecular pharmacology 20091201 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1. | Cellular signalling 20090401 |
| Synthesis and cytotoxic activity of new azepino[3',4':4,5]pyrrolo[2,1-a]isoquinolin-12-ones. | Bioorganic & medicinal chemistry 20090301 |
| Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity. | Cellular signalling 20090201 |
| Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. | The Journal of biological chemistry 20081107 |
| Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases. | Human reproduction (Oxford, England) 20080801 |
| Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. | Journal of neurochemistry 20080801 |
| 9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication. | Journal of medicinal chemistry 20080410 |
| Glycogen synthase kinases 3alpha and 3beta in cardiac myocytes: regulation and consequences of their inhibition. | Cellular signalling 20080101 |
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. | Proceedings of the National Academy of Sciences of the United States of America 20071218 |
| The selectivity of protein kinase inhibitors: a further update. | The Biochemical journal 20071215 |
| Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. | Journal of medicinal chemistry 20061214 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells. | European journal of medicinal chemistry 20050801 |
| Epoxide-containing side chains enhance antiproliferative activity of paullones. | European journal of medicinal chemistry 20050701 |
| GSK-3beta inhibition/beta-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons. | Journal of cell science 20041115 |
| A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. | Journal of medicinal chemistry 20041021 |
| 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. | Bioorganic & medicinal chemistry letters 20040119 |
| Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones. | Journal of medicinal chemistry 20040101 |
| The specificities of protein kinase inhibitors: an update. | The Biochemical journal 20030401 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? | The Journal of biological chemistry 20010105 |
| Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. | Cancer research 19990601 |
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