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1421-65-4 | L-Tyrosine, 3-hydroxy-, methyl ester, hydrochloride (1:1)
CAS No: 1421-65-4 Catalog No: AG001HT2 MDL No:MFCD00038958
Product Description
Catalog Number:
AG001HT2
Chemical Name:
L-Tyrosine, 3-hydroxy-, methyl ester, hydrochloride (1:1)
CAS Number:
1421-65-4
Molecular Formula:
C10H14ClNO4
Molecular Weight:
247.6755
MDL Number:
MFCD00038958
IUPAC Name:
methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate;hydrochloride
InChI:
InChI=1S/C10H13NO4.ClH/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6;/h2-3,5,7,12-13H,4,11H2,1H3;1H/t7-;/m0./s1
InChI Key:
WFGNJLMSYIJWII-FJXQXJEOSA-N
SMILES:
COC(=O)[C@H](Cc1ccc(c(c1)O)O)N.Cl
UNII:
JFU1A8866V
Properties
Complexity:
222
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
247.061g/mol
Formal Charge:
0
Heavy Atom Count:
16
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
247.675g/mol
Monoisotopic Mass:
247.061g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
92.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats. | International journal of nanomedicine 20120101 |
| Sustained-release formulation of levodopa methyl ester/benserazide for prolonged suppressing dyskinesia expression in 6-OHDA-leisoned rats. | Neuroscience letters 20110915 |
| Daily motor performance after switching levodopa to melevodopa: an open-label on advanced Parkinson's disease with 'delayed-on' and/or'wearing-off'. | Minerva medica 20110401 |
| Melevodopa/carbidopa effervescent formulation in the treatment of motor fluctuations in advanced Parkinson's disease. | Movement disorders : official journal of the Movement Disorder Society 20100915 |
| N-acetyl-L-methionyl-L-Dopa-methyl ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity. | Free radical biology & medicine 20100701 |
| A feasibility study of differential delivery of levodopa ester and benserazide using site-specific intestinal loops in rats. | Journal of pharmaceutical sciences 20100101 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Biperiden enhances L-DOPA methyl ester and dopamine D(l) receptor agonist SKF-82958 but antagonizes D(2)/D(3) receptor agonist rotigotine antihemiparkinsonian actions. | European journal of pharmacology 20081203 |
| L-dopa modulates motor cortex excitability in Alzheimer's disease patients. | Journal of neural transmission (Vienna, Austria : 1996) 20080901 |
| Clinical efficacy of a single afternoon dose of effervescent levodopa-carbidopa preparation (CHF 1512) in fluctuating Parkinson disease. | Clinical neuropharmacology 20070101 |
| Determination, purity assessment and chiral separation of levodopa methyl ester in bulk and formulation pharmaceuticals. | Biomedical chromatography : BMC 20060901 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Determination of levodopa methyl ester and its metabolites in rat serum by CZE with amperometric detection. | Analytical and bioanalytical chemistry 20050501 |
| Effects of (+/-)-idazoxan alone and in combination with L-DOPA methyl ester in MPTP-induced hemiparkinsonian monkeys. | Receptors & channels 20030101 |
| Kinetic characterisation of the reaction mechanism of mushroom tyrosinase on tyramine/dopamine and L-tyrosine methyl esther/L-dopa methyl esther. | The international journal of biochemistry & cell biology 20021201 |
| Opposite modulation of regulators of G protein signalling-2 RGS2 and RGS4 expression by dopamine receptors in the rat striatum. | Neuroscience letters 20021122 |
| Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20021115 |
| Influence of layer position on in vitro and in vivo release of levodopa methyl ester and carbidopa from three-layer matrix tablets. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20020301 |
| Effects of short- and long-acting dopamine agonists on sensitized dopaminergic neurotransmission in rats with unilateral 6-OHDA lesions. | Life sciences 20020118 |
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