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Home > Other Building Blocks > 1421-63-2
1421-63-2 | 1-Butanone, 1-(2,4,5-trihydroxyphenyl)-
CAS No: 1421-63-2 Catalog No: AG001HT3 MDL No:MFCD00020019
Product Description
Catalog Number:
AG001HT3
Chemical Name:
1-Butanone, 1-(2,4,5-trihydroxyphenyl)-
CAS Number:
1421-63-2
Molecular Formula:
C10H12O4
Molecular Weight:
196.1999
MDL Number:
MFCD00020019
IUPAC Name:
1-(2,4,5-trihydroxyphenyl)butan-1-one
InChI:
InChI=1S/C10H12O4/c1-2-3-7(11)6-4-9(13)10(14)5-8(6)12/h4-5,12-14H,2-3H2,1H3
InChI Key:
SRUQARLMFOLRDN-UHFFFAOYSA-N
SMILES:
CCCC(=O)c1cc(O)c(cc1O)O
UNII:
KN729W3LR0
NSC Number:
73478
Properties
Complexity:
204
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
196.074g/mol
Formal Charge:
0
Heavy Atom Count:
14
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
196.202g/mol
Monoisotopic Mass:
196.074g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
77.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.9
Literature
| Title | Journal |
|---|---|
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| Erythropoietin prevents endothelial dysfunction in GTP-cyclohydrolase I-deficient hph1 mice. | Journal of cardiovascular pharmacology 20141201 |
| Erythropoietin increases bioavailability of tetrahydrobiopterin and protects cerebral microvasculature against oxidative stress induced by eNOS uncoupling. | Journal of neurochemistry 20141101 |
| α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease. | Free radical biology & medicine 20140201 |
| Resveratrol improves vascular function in patients with hypertension and dyslipidemia by modulating NO metabolism. | Hypertension (Dallas, Tex. : 1979) 20130801 |
| Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein. | Cardiovascular research 20121201 |
| Cloning, expression and enzymatic properties analysis of dihydrofolate reductase gene from the silkworm, Bombyx mori. | Molecular biology reports 20121201 |
| Simultaneous quantification of tetrahydrobiopterin, dihydrobiopterin, and biopterin by liquid chromatography coupled electrospray tandem mass spectrometry. | Analytical biochemistry 20121115 |
| PPARδ agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 mice. | Brain research 20121105 |
| Efficacy and safety of BH4 before the age of 4 years in patients with mild phenylketonuria. | Journal of inherited metabolic disease 20121101 |
| Tetrahydrobiopterin (BH4) in PKU: effect on dietary treatment, metabolic control, and quality of life. | Journal of inherited metabolic disease 20121101 |
| An international survey of patients with tetrahydrobiopterin deficiencies presenting with hyperphenylalaninaemia. | Journal of inherited metabolic disease 20121101 |
| A volumetric study of basal ganglia structures in individuals with early-treated phenylketonuria. | Molecular genetics and metabolism 20121101 |
| The role of tetrahydrobiopterin in inflammation and cardiovascular disease. | Thrombosis and haemostasis 20121101 |
| Long-term treatment with tetrahydrobiopterin in phenylketonuria: treatment strategies and prediction of long-term responders. | Molecular genetics and metabolism 20121101 |
| Increased superoxide and endothelial NO synthase uncoupling in blood vessels of Bmal1-knockout mice. | Circulation research 20121012 |
| The mechanism of BH4 -responsive hyperphenylalaninemia--as it occurs in the ENU1/2 genetic mouse model. | Human mutation 20121001 |
| Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study. | American journal of hypertension 20121001 |
| Prevention of lethal murine pancreas ischemia reperfusion injury is specific for tetrahydrobiopterin. | Transplant international : official journal of the European Society for Organ Transplantation 20121001 |
| Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock. | Critical care medicine 20121001 |
| Tetrahydrobiopterin (BH4) in septic shock: a key to solving the nitric oxide puzzle and opening the microcirculation? | Critical care medicine 20121001 |
| Association between the levels of circulating adhesion molecules and biopterins in type-2 diabetic normotensive patients adhesion molecules and biopterins. | Endocrine, metabolic & immune disorders drug targets 20120901 |
| Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation. | Molecular pharmacology 20120901 |
| Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling. | Current heart failure reports 20120901 |
| Uncoupling of eNOS causes superoxide anion production and impairs NO signaling in the cerebral microvessels of hph-1 mice. | Journal of neurochemistry 20120901 |
| Utility of phenylalanine hydroxylase genotype for tetrahydrobiopterin responsiveness classification in patients with phenylketonuria. | Molecular genetics and metabolism 20120901 |
| Assessment of tetrahydrobiopterin (BH(4))-responsiveness and spontaneous phenylalanine reduction in a phenylalanine hydroxylase deficiency population. | Molecular genetics and metabolism 20120901 |
| Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation. | Circulation research 20120831 |
| Tetrahydrobiopterin ameliorates hepatic ischemia-reperfusion Injury by coupling with eNOS in mice. | The Journal of surgical research 20120801 |
| Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. | Free radical biology & medicine 20120715 |
| Electron paramagnetic resonance characterization of tetrahydrobiopterin radical formation in bacterial nitric oxide synthase compared to mammalian nitric oxide synthase. | Biophysical journal 20120703 |
| Recommendations for the use of sapropterin in phenylketonuria. | Molecular genetics and metabolism 20120701 |
| Uncoupling endothelial nitric oxide synthase is ameliorated by green tea in experimental diabetes by re-establishing tetrahydrobiopterin levels. | Diabetes 20120701 |
| Positive effect of a simplified diet on blood phenylalanine control in different phenylketonuria variants, characterized by newborn BH4 loading test and PAH analysis. | Molecular genetics and metabolism 20120701 |
| Endothelial nitric oxide synthase impairment is restored by clofibrate treatment in an animal model of hypertension. | European journal of pharmacology 20120615 |
| Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. | Arthritis and rheumatism 20120601 |
| Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. | Journal of cardiovascular pharmacology 20120601 |
| Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension. | American journal of physiology. Heart and circulatory physiology 20120601 |
| Five novel mutations and two large deletions in a population analysis of the phenylalanine hydroxylase gene. | Molecular genetics and metabolism 20120601 |
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| Advanced glycation end products-mediated hypertrophy is negatively regulated by tetrahydrobiopterin in renal tubular cells. | Molecular and cellular endocrinology 20120515 |
| Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status. | Free radical biology & medicine 20120515 |
| Insulin-induced generation of reactive oxygen species and uncoupling of nitric oxide synthase underlie the cerebrovascular insulin resistance in obese rats. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120501 |
| The spectrum of mutations identified in Cypriot patients with phenylalanine hydroxylase deficiency detected through neonatal screening. | Clinical biochemistry 20120501 |
| Novel pharmacological chaperones that correct phenylketonuria in mice. | Human molecular genetics 20120415 |
| Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells. | International journal of cardiology 20120405 |
| Nitric oxide synthases: regulation and function. | European heart journal 20120401 |
| Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase. | The Biochemical journal 20120401 |
| HPLC analysis of tetrahydrobiopterin and its pteridine derivatives using sequential electrochemical and fluorimetric detection: application to tetrahydrobiopterin autoxidation and chemical oxidation. | Archives of biochemistry and biophysics 20120401 |
| Quantification of phenylalanine hydroxylase activity by isotope-dilution liquid chromatography-electrospray ionization tandem mass spectrometry. | Molecular genetics and metabolism 20120401 |
| Evolving patient selection and clinical benefit criteria for sapropterin dihydrochloride (Kuvan®) treatment of PKU patients. | Molecular genetics and metabolism 20120401 |
| Rapid clearance of supplemented tetrahydrobiopterin is driven by high-capacity transporters in the kidney. | Molecular genetics and metabolism 20120401 |
| Which neuroprotective agents are ready for bench to bedside translation in the newborn infant? | The Journal of pediatrics 20120401 |
| Dopamine agonists in dihydropteridine reductase deficiency. | Molecular genetics and metabolism 20120401 |
| Direct detection of tetrahydrobiopterin (BH4) and dopamine in rat brain using liquid chromatography coupled electrospray tandem mass spectrometry. | Biochemical and biophysical research communications 20120323 |
| Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease. | Circulation 20120320 |
| Apocynin improves oxygenation and increases eNOS in persistent pulmonary hypertension of the newborn. | American journal of physiology. Lung cellular and molecular physiology 20120315 |
| Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin. | Cardiovascular research 20120315 |
| [Treatment and control of patients with phenylketonuria: results from the Collaborative Group of Spanish Follow-up Units]. | Medicina clinica 20120303 |
| Local tetrahydrobiopterin administration augments reflex cutaneous vasodilation through nitric oxide-dependent mechanisms in aged human skin. | Journal of applied physiology (Bethesda, Md. : 1985) 20120301 |
| Arg375 tunes tetrahydrobiopterin functions and modulates catalysis by inducible nitric oxide synthase. | Journal of inorganic biochemistry 20120301 |
| Tetrahydrobiopterin improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women. | American journal of physiology. Heart and circulatory physiology 20120301 |
| Simvastatin ameliorates angiotensin II-induced endothelial dysfunction through restoration of Rho-BH4-eNOS-NO pathway. | Cardiovascular drugs and therapy 20120201 |
| START, a double blind, placebo-controlled pharmacogenetic test of responsiveness to sapropterin dihydrochloride in phenylketonuria patients. | Molecular genetics and metabolism 20120201 |
| Changes in eNOS phosphorylation contribute to increased arteriolar NO release during juvenile growth. | American journal of physiology. Heart and circulatory physiology 20120201 |
| Propofol protects against high glucose-induced endothelial dysfunction in human umbilical vein endothelial cells. | Anesthesia and analgesia 20120201 |
| Analgesia by inhibiting tetrahydrobiopterin synthesis. | Current opinion in pharmacology 20120201 |
| The effects of modulating eNOS activity and coupling in ischemia/reperfusion (I/R). | Naunyn-Schmiedeberg's archives of pharmacology 20120101 |
| Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid. | Hypertension (Dallas, Tex. : 1979) 20120101 |
| Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases. | Journal of inorganic biochemistry 20120101 |
| Tetrahydrobiopterin, L-arginine and vitamin C actsynergistically to decrease oxidative stress, increase nitricoxide and improve blood flow after induction of hindlimbischemia in the rat. | Molecular medicine (Cambridge, Mass.) 20120101 |
| Role of neural NO synthase (nNOS) uncoupling in the dysfunctional nitrergic vasorelaxation of penile arteries from insulin-resistant obese Zucker rats. | PloS one 20120101 |
| Mechanism of cellular oxidation stress induced by asymmetric dimethylarginine. | International journal of molecular sciences 20120101 |
| Effects of tetrahydrobiopterin on cerebral infarction after transient focal ischemia in rats. | Neurological research 20111201 |
| Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice. | American journal of physiology. Heart and circulatory physiology 20111201 |
| Using change in plasma phenylalanine concentrations and ability to liberalize diet to classify responsiveness to tetrahydrobiopterin therapy in patients with phenylketonuria. | Molecular genetics and metabolism 20111201 |
| The tetrahydrobiopterin pathway: a novel target for the treatment of depression. | Pharmacogenomics 20111201 |
| Asymmetric uptake of sepiapterin and 7,8-dihydrobiopterin as a gateway of the salvage pathway of tetrahydrobiopterin biosynthesis from the lumenal surface of rat endothelial cells. | Molecular genetics and metabolism 20111101 |
| Autophagy induction by tetrahydrobiopterin deficiency. | Autophagy 20111101 |
| Natural phenylalanine hydroxylase variants that confer a mild phenotype affect the enzyme's conformational stability and oligomerization equilibrium. | Biochimica et biophysica acta 20111101 |
| Dual function of nitric oxide in carcinogenesis, reappraisal. | Current drug metabolism 20111101 |
| Biochemical characterization of the tetrahydrobiopterin synthesis pathway in the oleaginous fungus Mortierella alpina. | Microbiology (Reading, England) 20111101 |
| Disorders of BH4 metabolism and the treatment of patients with 6-pyruvoyl-tetrahydropterin synthase deficiency in Taiwan. | Brain & development 20111101 |
| Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction. | American journal of physiology. Heart and circulatory physiology 20111101 |
| Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning. | American journal of physiology. Heart and circulatory physiology 20111101 |
| [Lipid peroxidation and biomechanical properties of artery in hyperlipemia rats after treating with tetrahydrobiopterin]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20111101 |
| Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis. | Circulation 20111025 |
| Tetrahydrobiopterin is functionally distinguishable from tetrahydrodictyopterin in Dictyostelium discoideum Ax2. | FEBS letters 20111003 |
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| GCH1, BH4 and pain. | Current pharmaceutical biotechnology 20111001 |
| Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure. | Journal of molecular and cellular cardiology 20111001 |
| Modeling of biopterin-dependent pathways of eNOS for nitric oxide and superoxide production. | Free radical biology & medicine 20111001 |
| Ascorbic acid and N-acetyl cysteine prevent uncoupling of nitric oxide synthase and increase tolerance to ischemia/reperfusion injury in diabetic rat heart. | Free radical research 20111001 |
| Acute localized administration of tetrahydrobiopterin and chronic systemic atorvastatin treatment restore cutaneous microvascular function in hypercholesterolaemic humans. | The Journal of physiology 20111001 |
| Tetrahydrobiopterin: biochemistry and pathophysiology. | The Biochemical journal 20110915 |
| Tetrahydrobiopterin improves cardiac and pulmonary function after cardiopulmonary bypass. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20110901 |
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| Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK. | Arthritis and rheumatism 20110901 |
| Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo. | American journal of physiology. Heart and circulatory physiology 20110901 |
| Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase. | American journal of physiology. Lung cellular and molecular physiology 20110901 |
| eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity. | The Journal of endocrinology 20110901 |
| A novel high-throughput screening assay for discovery of molecules that increase cellular tetrahydrobiopterin. | Journal of biomolecular screening 20110901 |
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| Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice. | Clinical and experimental pharmacology & physiology 20110801 |
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| Tetrahydrobiopterin restores diastolic function and attenuates superoxide production in ovariectomized mRen2.Lewis rats. | Endocrinology 20110601 |
| Role of tetrahydrobiopterin (BH4) in hyperhomocysteinemia-induced endothelial dysfuction: new indication for this orphan-drug? | American journal of physiology. Endocrinology and metabolism 20110601 |
| A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis. | Nature chemical biology 20110601 |
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| Membrane transport of sepiapterin and dihydrobiopterin by equilibrative nucleoside transporters: a plausible gateway for the salvage pathway of tetrahydrobiopterin biosynthesis. | Molecular genetics and metabolism 20110101 |
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| Tetrahydrobiopterin does not affect end-organ responsiveness to norepinephrine-mediated vasoconstriction in aged skin. | American journal of physiology. Regulatory, integrative and comparative physiology 20101201 |
| Endothelial, sympathetic, and cardiac function in inherited (6R)-L-erythro-5,6,7,8-tetrahydro-L-biopterin deficiency. | Circulation. Cardiovascular genetics 20101201 |
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| Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection. | American journal of physiology. Heart and circulatory physiology 20100701 |
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| L-arginine and antioxidant diet supplementation partially restores nitric oxide-dependent regulation of phenylephrine renal vasoconstriction in diabetics rats. | Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20100501 |
| An important role of increase in tetrahydrobiopterin via H2O2-JAK2 signalling pathway in late phase of ischaemic preconditioning. | Experimental physiology 20100501 |
| Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats. | American journal of physiology. Gastrointestinal and liver physiology 20100501 |
| Endothelial dysfunction in diabetes: multiple targets for treatment. | Pflugers Archiv : European journal of physiology 20100501 |
| Identification and optimization of tyrosine hydroxylase activity in Mucuna pruriens DC. var. utilis. | Planta 20100501 |
| Nitric oxide and oxidative stress in vascular disease. | Pflugers Archiv : European journal of physiology 20100501 |
| Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice. | Heart and vessels 20100501 |
| Localized tyrosine or tetrahydrobiopterin supplementation corrects the age-related decline in cutaneous vasoconstriction. | The Journal of physiology 20100415 |
| Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition. | Biochemistry 20100413 |
| Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats. | European journal of pharmacology 20100410 |
| Alterations in the modulation of cerebrovascular tone and blood flow by nitric oxide synthases in SHRsp with stroke. | Cardiovascular research 20100401 |
| Long-chain polyunsaturated fatty acid status in phenylketonuric patients treated with tetrahydrobiopterin. | Clinical biochemistry 20100301 |
| Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin- and heat shock protein 90-mediated mechanisms. | Anesthesiology 20100301 |
| Mass spectroscopy and molecular modeling predict endothelial nitric oxide synthase dimer collapse by hydrogen peroxide through zinc tetrathiolate metal-binding site disruption. | DNA and cell biology 20100301 |
| Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production. | Archives of biochemistry and biophysics 20100215 |
| GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide. | Circulation research 20100205 |
| Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction. | Circulation 20100202 |
| NO way to relax: the complexities of coupling nitric oxide synthase pathways in the heart. | Circulation 20100202 |
| An enzymatic method to distinguish tetrahydrobiopterin from oxidized biopterins using UDP-glucose:tetrahydrobiopterin glucosyltransferase. | Analytical biochemistry 20100201 |
| Telmisartan improves endothelial dysfunction and renal autoregulation in Dahl salt-sensitive rats. | Hypertension research : official journal of the Japanese Society of Hypertension 20100201 |
| A weapon of endothelial cells for fighting vascular disease. | Hypertension research : official journal of the Japanese Society of Hypertension 20100201 |
| Tetrahydrobiopterin responsiveness after extended loading test of 12 Danish PKU patients with the Y414C mutation. | Journal of inherited metabolic disease 20100201 |
| Decreased arteriolar tetrahydrobiopterin is linked to superoxide generation from nitric oxide synthase in mice fed high salt. | Microcirculation (New York, N.Y. : 1994) 20100201 |
| Relative bioavailability of sapropterin from intact and dissolved sapropterin dihydrochloride tablets and the effects of food: a randomized, open-label, crossover study in healthy adults. | Clinical therapeutics 20100201 |
| Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia. | Cardiovascular research 20100101 |
| The effects of tetrahydrobiopterin on intracerebral hemorrhage-induced brain injury in mice. | Acta neurochirurgica. Supplement 20100101 |
| Regulation of nitric oxide production in health and disease. | Current opinion in clinical nutrition and metabolic care 20100101 |
| Evidence against tetrahydrobiopterin depletion of vascular tissue exposed to nitric oxide/superoxide or nitroglycerin. | Free radical biology & medicine 20100101 |
| Thiol-metabolizing proteins and endothelial redox state: differential modulation of eNOS and biopterin pathways. | American journal of physiology. Heart and circulatory physiology 20100101 |
| The tetrahydrobiopterin pathway and pain. | Current opinion in investigational drugs (London, England : 2000) 20100101 |
| [Phenylketonuria--toward a better carry-over care]. | Nihon rinsho. Japanese journal of clinical medicine 20100101 |
| Cognitive functions in patients with phenylketonuria in long-term treatment with tetrahydrobiopterin. | Molecular genetics and metabolism 20100101 |
| Clear correlation of tetrahydrobiopterin with nitric oxide bioavailability in continuous ambulatory peritoneal dialysis. | Blood purification 20100101 |
| Reaching out to the lost generation of adults with early-treated phenylketonuria (PKU). | Molecular genetics and metabolism 20100101 |
| Sapropterin therapy increases stability of blood phenylalanine levels in patients with BH4-responsive phenylketonuria (PKU). | Molecular genetics and metabolism 20100101 |
| Regulation of endothelial cell tetrahydrobiopterin pathophysiological and therapeutic implications. | Advances in pharmacology (San Diego, Calif.) 20100101 |
| Impaired endothelial function may be due to decreased aortic tetrahydrobiopterin, assessed by a new flow-mediated vasodilation in vivo in hypercholesterolemic/atherogenic mice. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20091201 |
| Identification and functional characterization of phosphorylation sites on GTP cyclohydrolase I. | Arteriosclerosis, thrombosis, and vascular biology 20091201 |
| Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: role of reactive oxygen species (ROS), eNOS, and heme oxygenase (HO-1) levels. | The Journal of biological chemistry 20091113 |
| Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide. | Cardiovascular research 20091101 |
| Examination of tetrahydrobiopterin pathway genes in autism. | Genes, brain, and behavior 20091101 |
| Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats. | American journal of physiology. Heart and circulatory physiology 20091101 |
| Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels. | Proteomics 20091101 |
| Ascorbic acid and tetrahydrobiopterin: looking beyond nitric oxide bioavailability. | Cardiovascular research 20091101 |
| Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor. | Journal of molecular and cellular cardiology 20091101 |
| eNOS uncoupling and endothelial dysfunction in aged vessels. | American journal of physiology. Heart and circulatory physiology 20091101 |
| Tetrahydrobiopterin, superoxide, and vascular dysfunction. | Free radical biology & medicine 20091015 |
| Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways. | The Journal of biological chemistry 20091009 |
| Do sauna therapy and exercise act by raising the availability of tetrahydrobiopterin? | Medical hypotheses 20091001 |
| Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats. | Journal of neurochemistry 20091001 |
| Nitric oxide and pain: 'Something old, something new'. | Acta anaesthesiologica Scandinavica 20091001 |
| [Fusion of field and laboratory studies on the investigation of arsenic]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20091001 |
| Inhibition of CDKS by roscovitine suppressed LPS-induced *NO production through inhibiting NFkappaB activation and BH4 biosynthesis in macrophages. | American journal of physiology. Cell physiology 20090901 |
| Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension. | Hypertension (Dallas, Tex. : 1979) 20090901 |
| Sapropterin: a new therapeutic agent for phenylketonuria. | The Annals of pharmacotherapy 20090901 |
| [Research advance in the treatment of phenylketonuria]. | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090901 |
| Tetrahydrobiopterin in the prevention of hypertonia in hypoxic fetal brain. | Annals of neurology 20090901 |
| Determination of marker pteridins and biopterin reduced forms, tetrahydrobiopterin and dihydrobiopterin, in human urine, using a post-column photoinduced fluorescence liquid chromatographic derivatization method. | Analytica chimica acta 20090819 |
| High-cholesterol diet augments endothelial dysfunction via elevated oxidative stress and reduced tetrahydrobiopterin in Ins2(Akita) mice, an autosomal dominant mutant type 1 diabetic model. | Clinical and experimental pharmacology & physiology 20090801 |
| GTP cyclohydrolase I expression is regulated by nitric oxide: role of cyclic AMP. | American journal of physiology. Lung cellular and molecular physiology 20090801 |
| Local tetrahydrobiopterin administration augments cutaneous vasoconstriction in aged humans. | The Journal of physiology 20090801 |
| Blood phenylalanine concentrations in patients with PAH-deficient hyperphenylalaninaemia off diet without and with three different single oral doses of tetrahydrobiopterin: assessing responsiveness in a model of statistical process control. | Journal of inherited metabolic disease 20090801 |
| Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles. | The Journal of physiology 20090801 |
| Exercising an option to prevent age related decline of vascular BH4 and uncoupling of eNOS. | The Journal of physiology 20090801 |
| Detection of tetrahydrobiopterin by LC-MS/MS in plasma from multiple species. | Bioanalysis 20090801 |
| [Biomechanical properties of artery in spontaneously hypertensive rats after treating with tetrahydrobiopterin]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20090801 |
| Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues. | Journal of biochemistry 20090701 |
| Genotype-predicted tetrahydrobiopterin (BH4)-responsiveness and molecular genetics in Croatian patients with phenylalanine hydroxylase (PAH) deficiency. | Molecular genetics and metabolism 20090701 |
| Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. | American journal of physiology. Heart and circulatory physiology 20090701 |
| Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia. | Brain : a journal of neurology 20090701 |
| Disorders of biopterin metabolism. | Journal of inherited metabolic disease 20090601 |
| Sepiapterin decreases acute rejection and apoptosis in cardiac transplants independently of changes in nitric oxide and inducible nitric-oxide synthase dimerization. | The Journal of pharmacology and experimental therapeutics 20090601 |
| Endothelium-specific GTP cyclohydrolase I overexpression accelerates refractory wound healing by suppressing oxidative stress in diabetes. | American journal of physiology. Endocrinology and metabolism 20090601 |
| PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major. | Current genetics 20090601 |
| Tetrahydrobiopterin, endothelial nitric oxide synthase, and mitochondrial function in the heart. | Hypertension (Dallas, Tex. : 1979) 20090601 |
| Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis. | Hypertension (Dallas, Tex. : 1979) 20090601 |
| A limited spectrum of phenylalanine hydroxylase mutations is observed in phenylketonuria patients in western Poland and implications for treatment with 6R tetrahydrobiopterin. | Journal of human genetics 20090601 |
| Novel therapeutic strategies targeting vascular redox in human atherosclerosis. | Recent patents on cardiovascular drug discovery 20090601 |
| GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression. | The Journal of biological chemistry 20090515 |
| Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells. | The Journal of biological chemistry 20090508 |
| L-arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease. | Atherosclerosis 20090501 |
| Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction. | American journal of physiology. Heart and circulatory physiology 20090501 |
| Efficacy of sapropterin dihydrochloride in increasing phenylalanine tolerance in children with phenylketonuria: a phase III, randomized, double-blind, placebo-controlled study. | The Journal of pediatrics 20090501 |
| Flow-induced dilation is mediated by Akt-dependent activation of endothelial nitric oxide synthase-derived hydrogen peroxide in mouse cerebral arteries. | Stroke 20090501 |
| Detrimental effect of combined exercise training and eNOS overexpression on cardiac function after myocardial infarction. | American journal of physiology. Heart and circulatory physiology 20090501 |
| Plasma tetrahydrobiopterin/dihydrobiopterin ratio: a possible marker of endothelial dysfunction. | Circulation journal : official journal of the Japanese Circulation Society 20090501 |
| Effects of tetrahydrobiopterin on venous bubble grade and acute diving-induced changes in cardiovascular function. | Clinical physiology and functional imaging 20090401 |
| Effect of uncoupling endothelial nitric oxide synthase on calcium homeostasis in aged porcine endothelial cells. | Cardiovascular research 20090401 |
| Optimizing the use of sapropterin (BH(4)) in the management of phenylketonuria. | Molecular genetics and metabolism 20090401 |
| Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions. | Proteomics 20090401 |
| Physarum nitric oxide synthases: genomic structures and enzymology of recombinant proteins. | The Biochemical journal 20090315 |
| Comparative computational analysis of active and inactive cofactors of nitric oxide synthase. | The journal of physical chemistry. B 20090312 |
| The solution electrochemistry of tetrahydrobiopterin revisited. | Nitric oxide : biology and chemistry 20090301 |
| Protective effect of bromocriptine against BH4-induced Cath.a cell death involving up-regulation of antioxidant enzymes. | Neuroscience letters 20090227 |
| Biochemical characterization of mutant phenylalanine hydroxylase enzymes and correlation with clinical presentation in hyperphenylalaninaemic patients. | Journal of inherited metabolic disease 20090201 |
| Tetrahydrobiopterin deficiency in human rabies. | Journal of inherited metabolic disease 20090201 |
| Significance of genotype in tetrahydrobiopterin-responsive phenylketonuria. | Journal of inherited metabolic disease 20090201 |
| Transcellular relocation of tetrahydrobiopterin across Caco-2 cells: a model study of tetrahydrobiopterin absorption through epithelial cells of intestinal mucosa. | Journal of inherited metabolic disease 20090201 |
| Pharmacokinetics of tetrahydrobiopterin following oral loadings with three single dosages in patients with phenylketonuria. | Journal of inherited metabolic disease 20090201 |
| Tetrahydrobiopterin in intestinal lumen: its absorption and secretion in the small intestine and the elimination in the large intestine. | Journal of inherited metabolic disease 20090201 |
| Effect of BH(4) supplementation on phenylalanine tolerance. | Journal of inherited metabolic disease 20090201 |
| H(2)O(2) increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo. | Journal of inherited metabolic disease 20090201 |
| A new role for caveolin-1: regulation of guanosine triphosphate cyclohydrolase I and tetrahydrobiopterin in endothelial cells. | Hypertension (Dallas, Tex. : 1979) 20090201 |
| Guanosine triphosphate cyclohydrolase I expression and enzymatic activity are present in caveolae of endothelial cells. | Hypertension (Dallas, Tex. : 1979) 20090201 |
| Tetrahydrobiopterin in biomedical research. | Journal of inherited metabolic disease 20090201 |
| Proceedings of the International Conference on Tetrahydrobiopterin, Phenylketonuria, and Nitric Oxide Synthase, St. Moritz/Champér, Switzerland, March 23-28, 2008. | Journal of inherited metabolic disease 20090201 |
| Reactive oxygen species production and MAPK activation are implicated in tetrahydrobiopterin-induced SH-SY5Y cell death. | Neuroscience letters 20090116 |
| Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression. | The Journal of biological chemistry 20090109 |
| Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence. | Biological chemistry 20090101 |
| Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects. | Trends in pharmacological sciences 20090101 |
| [Biopterin and child neurologic disease]. | No to hattatsu = Brain and development 20090101 |
| [Study of the photochemical properties of biopterin and its reduced forms]. | Prikladnaia biokhimiia i mikrobiologiia 20090101 |
| Nitric oxide and vascular insulin resistance. | BioFactors (Oxford, England) 20090101 |
| Sapropterin: a review of its use in the treatment of primary hyperphenylalaninaemia. | Drugs 20090101 |
| [Genotyping and treatment modification in patients with phenylketonuria: an introduction to pharmacogenomics]. | Przeglad lekarski 20090101 |
| [A novel strategy to design specific iNOS inhibitors]. | Medecine sciences : M/S 20090101 |
| Spotlight on sapropterin in primary hyperphenylalaninemia. | BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20090101 |
| Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care. | The Clinical journal of pain 20090101 |
| Changing dietary practices in phenylketonuria. | The Turkish journal of pediatrics 20090101 |
| Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081201 |
| Superoxide dismutase restores eNOS expression and function in resistance pulmonary arteries from neonatal lambs with persistent pulmonary hypertension. | American journal of physiology. Lung cellular and molecular physiology 20081201 |
| Bringing down the ROS: a new therapeutic approach for PPHN. | American journal of physiology. Lung cellular and molecular physiology 20081201 |
| Maternal phenylketonuria and tetrahydrobiopterin. | Pediatrics 20081201 |
| Diagnosis of tetrahydrobiopterin (BH4) responsive mild phenylketonuria in Japan over the past 10 years. | Annals of the Academy of Medicine, Singapore 20081201 |
| Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase. | The Journal of biological chemistry 20081128 |
| Crystal structure of tryptophan hydroxylase with bound amino acid substrate. | Biochemistry 20081118 |
| Safety and efficacy of 22 weeks of treatment with sapropterin dihydrochloride in patients with phenylketonuria. | American journal of medical genetics. Part A 20081115 |
| Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis. | The Journal of biological chemistry 20081114 |
| Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype. | European journal of pain (London, England) 20081101 |
| Dietary supplementation with cholesterol and docosahexaenoic acid increases the activity of the arginine-nitric oxide pathway in tissues of young pigs. | Nitric oxide : biology and chemistry 20081101 |
| Laminar shear stress inhibits lipid peroxidation induced by high glucose plus arachidonic acid in endothelial cells. | American journal of physiology. Heart and circulatory physiology 20081101 |
| Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes. | American journal of physiology. Heart and circulatory physiology 20081101 |
| A polarizable force-field model for quantum-mechanical-molecular-mechanical Hamiltonian using expansion of point charges into orbitals. | The Journal of chemical physics 20081021 |
| Ascorbate sustains neutrophil NOS expression, catalysis, and oxidative burst. | Free radical biology & medicine 20081015 |
| Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK. | Arteriosclerosis, thrombosis, and vascular biology 20081001 |
| Cytokines and lipopolysaccharides induce inducible nitric oxide synthase but not enzyme activity in adult rat cardiomyocytes. | Free radical biology & medicine 20081001 |
| Perivascular nitric oxide and superoxide in neonatal cerebral hypoxia-ischemia. | American journal of physiology. Heart and circulatory physiology 20081001 |
| CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis. | Circulation 20080930 |
| Evaluation of neonatal BH4 loading test in neonates screened for hyperphenylalaninemia. | Early human development 20080901 |
| Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure. | Hypertension (Dallas, Tex. : 1979) 20080901 |
| Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes. | Hypertension (Dallas, Tex. : 1979) 20080901 |
| Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats: the possible role of oxidative stress caused by uncoupled endothelial nitric oxide synthase. | Circulation journal : official journal of the Japanese Circulation Society 20080901 |
| Chronic immune stimulation correlates with reduced phenylalanine turnover. | Current drug metabolism 20080901 |
| The methylation, neurotransmitter, and antioxidant connections between folate and depression. | Alternative medicine review : a journal of clinical therapeutic 20080901 |
| Serum phenylalanine in patients post trauma and with sepsis correlate to neopterin concentrations. | Amino acids 20080801 |
| Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin. | Molecular genetics and metabolism 20080801 |
| Three-day tetrahydrobiopterin therapy increases in vivo hepatic NOS activity and reduces portal pressure in CCl4 cirrhotic rats. | Journal of hepatology 20080801 |
| Loss of function in phenylketonuria is caused by impaired molecular motions and conformational instability. | American journal of human genetics 20080711 |
| Regulation of eNOS-derived superoxide by endogenous methylarginines. | Biochemistry 20080708 |
| GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. | Journal of the American College of Cardiology 20080708 |
| Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase. | Journal of neurochemistry 20080701 |
| Exposure to inhaled particulate matter impairs cardiac function in senescent mice. | American journal of physiology. Regulatory, integrative and comparative physiology 20080701 |
| A plaidoyer for cutaneous enzymology: our view of some important unanswered questions on the contributions of selected key enzymes to epidermal homeostasis. | Experimental dermatology 20080701 |
| Development of a model for assessment of phenylalanine hydroxylase activity in newborns with phenylketonuria receiving tetrahydrobiopterin: a potential for practical implementation. | Molecular genetics and metabolism 20080701 |
| Erythropoietin increases endothelial biosynthesis of tetrahydrobiopterin by activation of protein kinase B alpha/Akt1. | Hypertension (Dallas, Tex. : 1979) 20080701 |
| New drugs08, part 2. | Nursing 20080701 |
| Sapropterin (Kuvan) for phenylketonuria. | The Medical letter on drugs and therapeutics 20080602 |
| Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension. | Antioxidants & redox signaling 20080601 |
| Tetrahydrobiopterin: a novel antihypertensive therapy. | Journal of human hypertension 20080601 |
| Reduced vascular tetrahydrobiopterin (BH4) and endothelial function with ageing: is it time for a chronic BH4 supplementation trial in middle-aged and older adults? | The Journal of physiology 20080601 |
| Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus. | Arteriosclerosis, thrombosis, and vascular biology 20080601 |
| Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration. | American journal of physiology. Heart and circulatory physiology 20080601 |
| Effect of pioglitazone on nitroglycerin-induced impairment of nitric oxide bioavailability by a catheter-type nitric oxide sensor. | Circulation journal : official journal of the Japanese Circulation Society 20080601 |
| Role of Phe-99 and Trp-196 of sepiapterin reductase from Chlorobium tepidum in the production of L-threo-tetrahydrobiopterin. | Acta biochimica et biophysica Sinica 20080601 |
| [BH4 in the management of phenylketonuria]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20080601 |
| Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy. | Circulation 20080520 |
| Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. | Atherosclerosis 20080501 |
| Regulation of melanogenesis--controversies and new concepts. | Experimental dermatology 20080501 |
| The adverse cardiopulmonary phenotype of caveolin-1 deficient mice is mediated by a dysfunctional endothelium. | Journal of molecular and cellular cardiology 20080501 |
| Effect of decreased levels of intrinsic tetrahydrobiopterin on endothelial function in anesthetized rats. | Journal of pharmacological sciences 20080501 |
| Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase. | The Journal of biological chemistry 20080425 |
| Microvascular function and ageing L-arginine, tetrahydrobiopterin and the search for the fountain of vascular youth. | The Journal of physiology 20080415 |
| Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia. | Heart (British Cardiac Society) 20080401 |
| Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS. | American journal of physiology. Heart and circulatory physiology 20080401 |
| [Mutation analysis and one novel mutation detection of 6-pyruvoyl tetrahydropterin synthase gene in children with tetrahydrobiopterin deficiency]. | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20080401 |
| Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase. | Archives of biochemistry and biophysics 20080315 |
| Letter by Thum et al regarding article, 'Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone'. | Circulation 20080311 |
| Outcome and long-term follow-up of 36 patients with tetrahydrobiopterin deficiency. | Molecular genetics and metabolism 20080301 |
| Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1. | American journal of physiology. Renal physiology 20080301 |
| IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction. | American journal of physiology. Regulatory, integrative and comparative physiology 20080301 |
| Recently-approved sapropterin reduces phenylalanine levels. | Managed care (Langhorne, Pa.) 20080301 |
| Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension. | Circulation 20080226 |
| Quinones are reduced by 6-tetrahydrobiopterin in human keratinocytes, melanocytes, and melanoma cells. | Free radical biology & medicine 20080215 |
| Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles. | The Journal of physiology 20080215 |
| A novel mutation (c.64_65delGGinsAACC [p.G21fsX66]) in the GTP cyclohydrolase 1 gene that causes Segawa disease. | Journal of neurology, neurosurgery, and psychiatry 20080201 |
| Classifying tetrahydrobiopterin responsiveness in the hyperphenylalaninaemias. | Journal of inherited metabolic disease 20080201 |
| Sapropterin dihydrochloride, 6-R-L-erythro-5,6,7,8-tetrahydrobiopterin, in the treatment of phenylketonuria. | Expert opinion on investigational drugs 20080201 |
| Defining tetrahydrobiopterin (BH4)-responsiveness in PKU. | Journal of inherited metabolic disease 20080201 |
| Tetrahydrobiopterin. | Current hypertension reports 20080201 |
| Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production. | Vascular medicine (London, England) 20080201 |
| First drug approved for treatment of phenylketonuria. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080115 |
| Oxygen-induced radical intermediates in the nNOS oxygenase domain regulated by L-arginine, tetrahydrobiopterin, and thiol. | Biochemistry 20080108 |
| A case of 6-pyruvoyl-tetrahydropterin synthase deficiency demonstrates a more significant correlation of L-Dopa dosage with serum prolactin levels than CSF homovanillic acid levels. | Brain & development 20080101 |
| Insulin resistance and endothelial cell dysfunction: studies in mammalian models. | Experimental physiology 20080101 |
| Molecular genetics of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency. | Human mutation 20080101 |
| Oral administration of tetrahydrobiopterin attenuates testicular damage by reducing nitric oxide synthase activity in a cryptorchid mouse model. | Journal of andrology 20080101 |
| Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formation. | Neuroscience research 20080101 |
| Diabetes induces changes of catecholamines in primary mesangial cells. | The international journal of biochemistry & cell biology 20080101 |
| Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells. | The international journal of biochemistry & cell biology 20080101 |
| Is sapropterin treatment suitable for all subjects with phenylketonuria? | Expert opinion on pharmacotherapy 20080101 |
| New drugs: nebivolol hydrochloride, nilotinib, and sapropterin dihydrochloride. | Journal of the American Pharmacists Association : JAPhA 20080101 |
| Effects of pioglitazone on nitric oxide bioavailability measured using a catheter-type nitric oxide sensor in angiotensin II-infusion rabbit. | Hypertension research : official journal of the Japanese Society of Hypertension 20080101 |
| 2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH(4)-independent manner. | Biochimica et biophysica acta 20080101 |
| Generalised cranial artery spasm in human rabies. | Developments in biologicals 20080101 |
| Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia. | Journal of anesthesia 20080101 |
| Exercise training enhanced myocardial endothelial nitric oxide synthase (eNOS) function in diabetic Goto-Kakizaki (GK) rats. | Cardiovascular diabetology 20080101 |
| Pharmacokinetics of sapropterin in patients with phenylketonuria. | Clinical pharmacokinetics 20080101 |
| Effects of tetrahydrobiopterin on nitric oxide bioavailability and renal hemodynamics in healthy volunteers. | Journal of nephrology 20080101 |
| Metabolism of tetrahydrobiopterin: its relevance in monoaminergic neurons and neurological disorders. | Chemical record (New York, N.Y.) 20080101 |
| Effects of tetrahydrobiopterin on coronary vascular reactivity in atherosclerotic human coronary arteries. | Cardiovascular research 20071201 |
| Effects of tetrahydrobiopterin and phenylalanine on in vivo human phenylalanine hydroxylase by phenylalanine breath test. | Molecular genetics and metabolism 20071201 |
| Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure. | Arteriosclerosis, thrombosis, and vascular biology 20071201 |
| C-reactive protein decreases endothelial nitric oxide synthase activity via uncoupling. | Journal of molecular and cellular cardiology 20071201 |
| Endothelium-targeted transgenic GTP-cyclohydrolase I overexpression inhibits neointima formation in mouse carotid artery. | Clinical and experimental pharmacology & physiology 20071201 |
| Recommendations for evaluation of responsiveness to tetrahydrobiopterin (BH(4)) in phenylketonuria and its use in treatment. | Molecular genetics and metabolism 20071201 |
| Uncoupled endothelial nitric oxide synthase and oxidative stress in a rat model of pregnancy-induced hypertension. | American journal of hypertension 20071201 |
| The potential anti-inflammatory effect of tetrahydrobiopterin administration in renal mass reduction-induced chronic renal failure in rats. | Saudi medical journal 20071201 |
| Hydrogen sulfide inhibits activity of three isoforms of recombinant nitric oxide synthase. | Toxicology 20071120 |
| 4-Hydroxy-2-nonenal increases superoxide anion radical in endothelial cells via stimulated GTP cyclohydrolase proteasomal degradation. | Arteriosclerosis, thrombosis, and vascular biology 20071101 |
| Sapropterin dihydrochloride (Kuvan/phenoptin), an orally active synthetic form of BH4 for the treatment of phenylketonuria. | IDrugs : the investigational drugs journal 20071101 |
| Oxygenase domain of Drosophila melanogaster nitric oxide synthase: unique kinetic parameters enable a more efficient NO release. | Biochemistry 20071023 |
| Regulation of tetrahydrobiopterin biosynthesis by shear stress. | Circulation research 20071012 |
| Endothelial cell tetrahydrobiopterin: going with the flow. | Circulation research 20071012 |
| The tetrahydrobiopterin loading test in 36 patients with hyperphenylalaninaemia: evaluation of response and subsequent treatment. | Journal of inherited metabolic disease 20071001 |
| The response of patients with phenylketonuria and elevated serum phenylalanine to treatment with oral sapropterin dihydrochloride (6R-tetrahydrobiopterin): a phase II, multicentre, open-label, screening study. | Journal of inherited metabolic disease 20071001 |
| Oxygen metabolism by endothelial nitric-oxide synthase. | The Journal of biological chemistry 20070928 |
| A simple method to calculate the accessible volume of protein-bound ligands: application for ligand selectivity. | Journal of molecular graphics & modelling 20070901 |
| Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice. | Synapse (New York, N.Y.) 20070901 |
| [Molecular mechanism of cardiovascular damage induced by aldosterone]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070901 |
| Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease. | Journal of cardiovascular pharmacology 20070901 |
| Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus. | Circulation 20070821 |
| Interaction energies between tetrahydrobiopterin analogues and aromatic residues in tyrosine hydroxylase and phenylalanine hydroxylase. | The journal of physical chemistry. B 20070816 |
| Tetrahydrobiopterin for patients with phenylketonuria. | Lancet (London, England) 20070811 |
| Efficacy of sapropterin dihydrochloride (tetrahydrobiopterin, 6R-BH4) for reduction of phenylalanine concentration in patients with phenylketonuria: a phase III randomised placebo-controlled study. | Lancet (London, England) 20070811 |
| Role of cyclooxygenase-2 in tetrahydrobiopterin-induced dopamine oxidation. | Biochemical and biophysical research communications 20070803 |
| Effects and clinical significance of tetrahydrobiopterin supplementation in phenylalanine hydroxylase-deficient hyperphenylalaninaemia. | Journal of inherited metabolic disease 20070801 |
| Additive renoprotective effect of candesartan and tetrahydrobiopterin in rats after 5/6 nephrectomy. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070701 |
| A specific role for eNOS-derived reactive oxygen species in atherosclerosis progression. | Arteriosclerosis, thrombosis, and vascular biology 20070701 |
| Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease. | Clinical science (London, England : 1979) 20070701 |
| Nitric oxide accelerates the degradation of tetrahydrobiopterin but not total neopterin in cerebrospinal fluid; potential implications for the assessment of tetrahydrobiopterin metabolism. | Annals of clinical biochemistry 20070701 |
| Advances in melanocyte basic science research. | Dermatologic clinics 20070701 |
| Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production. | Journal of cardiovascular pharmacology 20070701 |
| Metabolic basis of sexual dimorphism in PKU mice after genome-targeted PAH gene therapy. | Molecular therapy : the journal of the American Society of Gene Therapy 20070601 |
| (6R)-5,6,7,8-tetrahydro-L-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm. | Arteriosclerosis, thrombosis, and vascular biology 20070601 |
| Effect of peripherally administered lipopolysaccharide (LPS) on GTP cyclohydrolase I, tetrahydrobiopterin and norepinephrine in the locus coeruleus in mice. | Stress (Amsterdam, Netherlands) 20070601 |
| Assessment of tetrahydrobiopterin (BH4) responsiveness in phenylketonuria. | The Journal of pediatrics 20070601 |
| Fluvastatin reverses endothelial dysfunction and increased vascular oxidative stress in rat adjuvant-induced arthritis. | Arthritis and rheumatism 20070601 |
| [Clinical study of tetrahydrobiopterin responsive phenylalanine hydroxylase deficiency in southern and northern Chinese patients]. | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20070601 |
| Primary role of superoxide anion generation in the cascade of events leading to endothelial dysfunction and damage in high glucose treated HUVEC. | Nutrition, metabolism, and cardiovascular diseases : NMCD 20070501 |
| BH4 responsiveness associated to a PKU mutation with decreased binding affinity for the cofactor. | Clinica chimica acta; international journal of clinical chemistry 20070501 |
| Early initiation of L-dopa therapy enables stable development of executive function in tetrahydrobiopterin (BH4) deficiency. | Developmental medicine and child neurology 20070501 |
| Nitric oxide modulates expression of extracellular matrix genes linked to fibrosis in kidney mesangial cells. | Biological chemistry 20070501 |
| Tetrahydrobiopterin availability, nitric oxide metabolism and glutathione status in the hph-1 mouse; implications for the pathogenesis and treatment of tetrahydrobiopterin deficiency states. | Journal of inherited metabolic disease 20070401 |
| Protective effect of sulforaphane against dopaminergic cell death. | The Journal of pharmacology and experimental therapeutics 20070401 |
| Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II. | Arteriosclerosis, thrombosis, and vascular biology 20070401 |
| Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice. | Arteriosclerosis, thrombosis, and vascular biology 20070401 |
| Phenylketonuria: dietary and therapeutic challenges. | Journal of inherited metabolic disease 20070401 |
| Regulation of GTP cyclohydrolase I expression by orphan receptor Nurr1 in cell culture and in vivo. | Journal of neurochemistry 20070401 |
| [Screening for tetrahydrobiopterin metabolic disorders and related gene analysis among the patients with motor disturbance and mental retardation]. | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20070401 |
| Sepiapterin reductase expression is increased in Parkinson's disease brain tissue. | Brain research 20070330 |
| Intracortical inhibition of the motor cortex in Segawa disease (DYT5). | Neurology 20070327 |
| Interaction of genetic and environmental factors in a Drosophila parkinsonism model. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070307 |
| Molecular genetics of tetrahydrobiopterin (BH4) deficiency in the Maltese population. | Molecular genetics and metabolism 20070301 |
| Quantitation of total biopterin and tetrahydrobiopterin in plasma. | Clinical biochemistry 20070301 |
| Folic acid prevents and partially reverses glucocorticoid-induced hypertension in the rat. | American journal of hypertension 20070301 |
| Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes. | Diabetes 20070301 |
| [Molecular imaging for drug development]. | Brain and nerve = Shinkei kenkyu no shinpo 20070301 |
| Oral administration of both tetrahydrobiopterin and L-arginine prevents endothelial dysfunction in rats with chronic renal failure. | Journal of cardiovascular pharmacology 20070301 |
| Insulin enhances nitric oxide production in trabecular meshwork cells via de novo pathway for tetrahydrobiopterin synthesis. | Korean journal of ophthalmology : KJO 20070301 |
| Buthionine sulfoximine causes endothelium dependent hyper-relaxation and hypoadiponectinemia. | Life sciences 20070206 |
| Oxidative stress via hydrogen peroxide affects proopiomelanocortin peptides directly in the epidermis of patients with vitiligo. | The Journal of investigative dermatology 20070201 |
| 17beta-estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease. | The Journal of pharmacology and experimental therapeutics 20070201 |
| Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats. | European journal of pharmacology 20070119 |
| Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP cyclohydrolase 1 double transgenic mice. | Experimental physiology 20070101 |
| Particular vulnerability of rat mesencephalic dopaminergic neurons to tetrahydrobiopterin: Relevance to Parkinson's disease. | Neurobiology of disease 20070101 |
| Ribavirin inhibits angiogenesis by tetrahydrobiopterin depletion. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070101 |
| Analysis of plasma biopterin levels in psychiatric disorders suggests a common BH4 deficit in schizophrenia and schizoaffective disorder. | Neurochemical research 20070101 |
| Tetrahydrobiopterin availability in Parkinson's and Alzheimer's disease; potential pathogenic mechanisms. | Neurochemical research 20070101 |
| Chemiluminescence assay for tetrahydrobiopterin based on the generation of hydrogen peroxide using isoluminol-microperoxidase in the presence of 1-methoxy PMS. | Luminescence : the journal of biological and chemical luminescence 20070101 |
| Effects of supplementation of BH4 after prolonged ischemia in skeletal muscle. | Microsurgery 20070101 |
| C-Reactive protein-induced endothelial microparticle generation in HUVECs is related to BH4-dependent NO formation. | Journal of vascular research 20070101 |
| Assessment of tetrahydrobiopterin responsiveness in Turkish hyperphenylalaninemic patients. | The Turkish journal of pediatrics 20070101 |
| Mutations in the regulatory domain of phenylalanine hydroxylase and response to tetrahydrobiopterin. | Genetic testing 20070101 |
| Paradoxical effects of two oximes on nitric oxide production by purified NO synthases, in cell culture and in animals. | Nitric oxide : biology and chemistry 20070101 |
| Glucocorticoids and oxidative stress. | Journal of basic and clinical physiology and pharmacology 20070101 |
| Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments. | Clinical hemorheology and microcirculation 20070101 |
| Gamma-tocopherol may promote effective no synthase function by protecting tetrahydrobiopterin from peroxynitrite. | Medical hypotheses 20070101 |
| Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. | Journal of neural transmission. Supplementum 20070101 |
| Plasma pterins and folate in late life depression: the Rotterdam Study. | Psychiatry research 20061207 |
| Pharmacokinetics of orally administered tetrahydrobiopterin in patients with phenylalanine hydroxylase deficiency. | Journal of inherited metabolic disease 20061201 |
| [Detection of the prevalent mutations of 6-pyruvoyl-tetrahydropterin synthase gene by PCR-RFLP analysis in Chinese patients]. | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20061201 |
| Electronic structure, ionization potential, and electron affinity of the enzyme cofactor (6R)-5,6,7,8-tetrahydrobiopterin in the gas phase, solution, and protein environments. | The journal of physical chemistry. B 20061116 |
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | Journal of molecular graphics & modelling 20061101 |
| GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes. | The Journal of investigative dermatology 20061101 |
| Tetrahydrobiopterin and cardiovascular disease. | Arteriosclerosis, thrombosis, and vascular biology 20061101 |
| GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. | Nature medicine 20061101 |
| Feeling pain? Who's your daddy... | Nature medicine 20061101 |
| Self-assembly of the 2-His-1-carboxylate facial triad in mononuclear iron(II) and zinc(II) models of metalloenzyme active sites. | Inorganic chemistry 20061002 |
| Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20061001 |
| 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. | Circulation 20060912 |
| The role of tetrahydrobiopterin in catalysis by nitric oxide synthase. | Chemical communications (Cambridge, England) 20060907 |
| 6-Pyruvoyltetrahydropterin synthase orthologs of either a single or dual domain structure are responsible for tetrahydrobiopterin synthesis in bacteria. | FEBS letters 20060904 |
| Tetrahydrobiopterin protects against guanabenz-mediated inhibition of neuronal nitric-oxide synthase in vitro and in vivo. | Drug metabolism and disposition: the biological fate of chemicals 20060901 |
| Systemic oxidative stress associated with lung resection during single lung ventilation. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060901 |
| Effect of tetrahydrobiopterin on selective endothelial dysfunction of epicardial porcine coronary arteries induced by cardiopulmonary bypass. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060901 |
| Early determinants of H2O2-induced endothelial dysfunction. | Free radical biology & medicine 20060901 |
| Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase. | Human mutation 20060901 |
| Three-year audit of the hyperphenylalaninaemia/phenylketonuria spectrum in Victoria. | Journal of paediatrics and child health 20060901 |
| Decrease in tetrahydrobiopterin as a possible cause of nephropathy in type II diabetic rats. | Kidney international 20060801 |
| Pigment pattern formation in the quail mutant of the silkworm, Bombyx mori: parallel increase of pteridine biosynthesis and pigmentation of melanin and ommochromes. | Pigment cell research 20060801 |
| Inefficient spin trapping of superoxide in the presence of nitric-oxide: implications for studies on nitric-oxide synthase uncoupling. | Free radical biology & medicine 20060801 |
| Ascorbic acid synthesis due to L-gulono-1,4-lactone oxidase expression enhances NO production in endothelial cells. | Biochemical and biophysical research communications 20060714 |
| Tetrahydrobiopterin stimulates L-DOPA release from striatal tissue. | European journal of pharmacology 20060710 |
| eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling. | Circulation research 20060707 |
| Manganese modulates pro-inflammatory gene expression in activated glia. | Neurochemistry international 20060701 |
| Endothelial NO synthase target of aldosterone. | Hypertension (Dallas, Tex. : 1979) 20060701 |
| Molecular mechanism of the inhibitory effect of aldosterone on endothelial NO synthase activity. | Hypertension (Dallas, Tex. : 1979) 20060701 |
| The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis. | Hepatology (Baltimore, Md.) 20060701 |
| Tetrahydrobiopterin attenuates microvascular reperfusion injury following murine pancreas transplantation. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060701 |
| Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production. | Atherosclerosis 20060601 |
| Cytokine-induced metabolic effects in human adipocytes are independent of endogenous nitric oxide. | American journal of physiology. Endocrinology and metabolism 20060601 |
| Increased vascular biosynthesis of tetrahydrobiopterin in apolipoprotein E-deficient mice. | American journal of physiology. Heart and circulatory physiology 20060601 |
| Regulation of inducible nitric oxide synthase in post-operative adhesions. | Human reproduction (Oxford, England) 20060601 |
| A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions. | Journal of neurochemistry 20060601 |
| Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase-serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution. | Free radical biology & medicine 20060601 |
| Endothelial dysfunction in rat adjuvant-induced arthritis: vascular superoxide production by NAD(P)H oxidase and uncoupled endothelial nitric oxide synthase. | Arthritis and rheumatism 20060601 |
| [Study on tetrahydrobiopterin deficiency in Northern Chinese population]. | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20060601 |
| Catalase protects cardiomyocytes via its inhibition of nitric oxide synthesis. | Nitric oxide : biology and chemistry 20060501 |
| A murine model for human sepiapterin-reductase deficiency. | American journal of human genetics 20060401 |
| Circadian rhythms in RLS. | Sleep medicine 20060401 |
| Evaluation of electrospray-tandem mass spectrometry for the detection of phenylketonuria and other rare disorders. | Molecular nutrition & food research 20060401 |
| Molecular mechanism for pterin-mediated inactivation of tyrosine hydroxylase: formation of insoluble aggregates of tyrosine hydroxylase. | Journal of biochemistry 20060401 |
| Cardioprotective effects of tetrahydrobiopterin in cold heart preservation after cardiac arrest. | Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20060401 |
| Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide. | The Journal of biological chemistry 20060324 |
| Analysis of the effect of tetrahydrobiopterin on PAH gene expression in hepatoma cells. | FEBS letters 20060320 |
| Administration of secretin for autism alters dopamine metabolism in the central nervous system. | Brain & development 20060301 |
| Functional identification of orthologous genes encoding pterin recycling activity in Plasmodium falciparum and Toxoplasma gondii. | Molecular and biochemical parasitology 20060301 |
| Tetrahydrobiopterin causes mitochondrial dysfunction in dopaminergic cells: implications for Parkinson's disease. | Neurochemistry international 20060301 |
| High-pressure studies of the reaction mechanism of nitric-oxide synthase. | Biochimica et biophysica acta 20060301 |
| Dissociation and unfolding of inducible nitric oxide synthase oxygenase domain identifies structural role of tetrahydrobiopterin in modulating the heme environment. | Molecular and cellular biochemistry 20060301 |
| Evaluation of tetrahydrobiopterin (BH4) as a potential therapeutic agent to treat erectile dysfunction. | Asian journal of andrology 20060301 |
| Cytoprotective function of tetrahydrobiopterin in rat liver ischemia/reperfusion injury. | Surgery 20060301 |
| Tetrahydrobiopterin compounds prolong allograft survival independently of their effect on nitric oxide synthase activity. | Transplantation 20060227 |
| Reduction and oxidation of the active site iron in tyrosine hydroxylase: kinetics and specificity. | Biochemistry 20060221 |
| eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally. | American journal of physiology. Lung cellular and molecular physiology 20060201 |
| Increased blood flow causes coordinated upregulation of arterial eNOS and biosynthesis of tetrahydrobiopterin. | American journal of physiology. Heart and circulatory physiology 20060201 |
| Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency. | Molecular genetics and metabolism 20060201 |
| Reduction of myocardial infarct size by tetrahydrobiopterin: possible involvement of mitochondrial KATP channels activation through nitric oxide production. | Journal of cardiovascular pharmacology 20060201 |
| [Tetrahydrobiopterin therapy for hyperphenylalaninemia due to phenylalanine hydroxylase deficiency. When and how?]. | Anales de pediatria (Barcelona, Spain : 2003) 20060201 |
| The spectrum of phenylalanine variations under tetrahydrobiopterin load in subjects affected by phenylalanine hydroxylase deficiency. | Journal of inherited metabolic disease 20060201 |
| Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin. | The Journal of biological chemistry 20060127 |
| Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis. | European journal of pharmacology 20060120 |
| Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060111 |
| A burning issue: do sepsis and systemic inflammatory response syndrome (SIRS) directly contribute to cardiac dysfunction? | Frontiers in bioscience : a journal and virtual library 20060101 |
| Neural tube closure depends on nitric oxide synthase activity. | Journal of neurochemistry 20060101 |
| Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats. | Journal of hypertension 20060101 |
| Tetrahydrobiopterin, but not L-arginine, decreases NO synthase uncoupling in cells expressing high levels of endothelial NO synthase. | Hypertension (Dallas, Tex. : 1979) 20060101 |
| Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates. | The FEBS journal 20060101 |
| [Dopa-responsive dystonia: clinical, genetic, and biochemical studies]. | Rinsho shinkeigaku = Clinical neurology 20060101 |
| Estrogen therapy replenishes vascular tetrahydrobiopterin and reduces oxidative stress in ovariectomized rats. | Menopause (New York, N.Y.) 20060101 |
| Correction of endothelial dysfunction in diabetic female rats by tetrahydrobiopterin and chronic insulin. | Journal of vascular research 20060101 |
| Activation energy determinations suggest that thiols reverse autooxidation of tetrahydrobiopterin by a different mechanism than ascorbate. | The international journal of biochemistry & cell biology 20060101 |
| Protection of endothelial function: targets for nutritional and pharmacological interventions. | Journal of cardiovascular pharmacology 20060101 |
| Nitric oxide and neopterin in bipolar affective disorder. | Neuropsychobiology 20060101 |
| Novel therapies targeting vascular endothelium. | Endothelium : journal of endothelial cell research 20060101 |
| Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase. | Brain research. Molecular brain research 20051207 |
| The activity of wild-type and mutant phenylalanine hydroxylase and its regulation by phenylalanine and tetrahydrobiopterin at physiological and pathological concentrations: an isothermal titration calorimetry study. | Molecular genetics and metabolism 20051201 |
| Clinical and nutritional evaluation of phenylketonuric patients on tetrahydrobiopterin monotherapy. | Molecular genetics and metabolism 20051201 |
| Long-term treatment with tetrahydrobiopterin increases phenylalanine tolerance in children with severe phenotype of phenylketonuria. | Molecular genetics and metabolism 20051201 |
| Kinetic and stability analysis of PKU mutations identified in BH4-responsive patients. | Molecular genetics and metabolism 20051201 |
| Tetrahydrobiopterin-responsive phenylketonuria: the New South Wales experience. | Molecular genetics and metabolism 20051201 |
| Response of patients with phenylketonuria in the US to tetrahydrobiopterin. | Molecular genetics and metabolism 20051201 |
| Accumulated BH4 in mouse liver caused by administration of either 6R- or 6SBH4 consisted solely of the 6R-diastereomer: evidence of oxidation to BH2 and enzymic reduction. | Molecular genetics and metabolism 20051201 |
| Spanish BH4-responsive phenylalanine hydroxylase-deficient patients: evolution of seven patients on long-term treatment with tetrahydrobiopterin. | Molecular genetics and metabolism 20051201 |
| Cellular accumulation of tetrahydrobiopterin following its administration is mediated by two different processes; direct uptake and indirect uptake mediated by a methotrexate-sensitive process. | Molecular genetics and metabolism 20051201 |
| Neonatal hyperphenylalaninemia, perinatal hemochromatosis, and renal tubulopathy: a unique patient or a novel metabolic disorder? | Molecular genetics and metabolism 20051201 |
| Plasma biopterin levels and tetrahydrobiopterin responsiveness. | Molecular genetics and metabolism 20051201 |
| Incidence of BH4-responsiveness in phenylalanine-hydroxylase-deficient Italian patients. | Molecular genetics and metabolism 20051201 |
| Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. | Arteriosclerosis, thrombosis, and vascular biology 20051201 |
| Long-term treatment of patients with mild and classical phenylketonuria by tetrahydrobiopterin. | Molecular genetics and metabolism 20051201 |
| Delivery of exogenous tetrahydrobiopterin (BH4) to cells of target organs: role of salvage pathway and uptake of its precursor in effective elevation of tissue BH4. | Molecular genetics and metabolism 20051201 |
| Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper. | Molecular genetics and metabolism 20051201 |
| Inhibition of brain GTP cyclohydrolase I and tetrahydrobiopterin attenuates cerebral infarction via reducing inducible NO synthase and peroxynitrite in ischemic stroke. | Stroke 20051201 |
| Extended tetrahydrobiopterin loading test in the diagnosis of cofactor-responsive phenylketonuria: a pilot study. | Molecular genetics and metabolism 20051201 |
| Stimulation of hepatic phenylalanine hydroxylase activity but not Pah-mRNA expression upon oral loading of tetrahydrobiopterin in normal mice. | Molecular genetics and metabolism 20051201 |
| Tetrahydrobiopterin and maternal PKU. | Molecular genetics and metabolism 20051201 |
| Exploring the redox reactions between heme and tetrahydrobiopterin in the nitric oxide synthases. | Dalton transactions (Cambridge, England : 2003) 20051107 |
| Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities. | Journal of neurochemistry 20051101 |
| Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. | The Journal of physiology 20051101 |
| Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression. | Circulation research 20051028 |
| Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: role of tetrahydrobiopterin, nitric oxide, and proteasome activation. | Free radical biology & medicine 20051015 |
| Hypercholesterolemia abrogates late preconditioning via a tetrahydrobiopterin-dependent mechanism in conscious rabbits. | Circulation 20051004 |
| Tetrahydrobiopterin corrects Escherichia coli endotoxin-induced endothelial dysfunction. | American journal of physiology. Heart and circulatory physiology 20051001 |
| Roles of Ca2+ and the Ca2+-sensing receptor (CASR) in the expression of inducible NOS (nitric oxide synthase)-2 and its BH4 (tetrahydrobiopterin)-dependent activation in cytokine-stimulated adult human astrocytes. | Journal of cellular biochemistry 20051001 |
| Supplement of tetrahydrobiopterin by a gene transfer of GTP cyclohydrolase I cDNA improves vascular dysfunction in insulin-resistant rats. | Journal of cardiovascular pharmacology 20051001 |
| Tetrahydrobiopterin in the treatment of children with autistic disorder: a double-blind placebo-controlled crossover study. | Journal of clinical psychopharmacology 20051001 |
| Immobilization stress causes increases in tetrahydrobiopterin, dopamine, and neuromelanin and oxidative damage in the nigrostriatal system. | Journal of neurochemistry 20051001 |
| Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation. | Diabetologia 20050901 |
| Tetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury. | American journal of physiology. Regulatory, integrative and comparative physiology 20050801 |
| An oxygraphic method for determining kinetic properties and catalytic mechanism of aromatic amino acid hydroxylases. | Analytical biochemistry 20050801 |
| [Tetrahydrobiopterin loading test in differential diagnosis among hyperphenylalaninemia patients]. | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20050801 |
| Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases. | Journal of medicinal chemistry 20050728 |
| Syntheses of NAMDA derivatives inhibiting NO production in BV-2 cells stimulated with lipopolysaccharide. | Bioorganic & medicinal chemistry letters 20050715 |
| Correction of endothelial dysfunction by tetrahydrobiopterin: new hope for the treatment of arterial hypertension? | Journal of hypertension 20050701 |
| Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress. | Journal of hypertension 20050701 |
| 6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia. | Annals of neurology 20050701 |
| NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy. | American journal of physiology. Renal physiology 20050601 |
| Severe mucitis after sublingual administration of tetrahydrobiopterin in a patient with tetrahydrobiopterin-responsive phenylketonuria. | European journal of pediatrics 20050601 |
| Angiotensin-II-induced oxidative stress elicits hypoadiponectinaemia in rats. | Diabetologia 20050601 |
| Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production. | Journal of neurochemistry 20050601 |
| Cyclosporine-induced coronary endothelial dysfunction: is tetrahydrobiopterin the solution? | Transplantation proceedings 20050601 |
| Tetrahydrobiopterin and nitric oxide synthase dimer levels are not changed following hypoxia-ischemia in the newborn rat. | Brain research. Developmental brain research 20050512 |
| Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: Role of neuronal nitric oxide synthase. | Critical care medicine 20050501 |
| Reductive activation of Cr(Vi) by nitric oxide synthase. | Chemical research in toxicology 20050501 |
| [Screening and diagnosis of tetrahydrobiopterin responsive phenylalanine hydroxylase deficiency with tetrahydrobiopterin loading test]. | Zhonghua er ke za zhi = Chinese journal of pediatrics 20050501 |
| Tetrahydrobiopterin prevents cyclosporine-induced vasomotor dysfunction. | Transplantation 20050427 |
| Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse. | Circulation 20050426 |
| Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension. | Circulation 20050426 |
| Tetrahydrobiopterin in pulmonary hypertension: pulmonary hypertension in guanosine triphosphate-cyclohydrolase-deficient mice. | Circulation 20050426 |
| Regulation of tyrosinase by tetrahydropteridines--what is real? A comment on the work published by Wood et al. on December 24, 2004. | Biochemical and biophysical research communications 20050415 |
| Possible involvement of hydroxyl radical on the stimulation of tetrahydrobiopterin synthesis by hydrogen peroxide and peroxynitrite in vascular endothelial cells. | The international journal of biochemistry & cell biology 20050401 |
| A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms. | Biochemistry 20050329 |
| Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex. | Neuron 20050324 |
| Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes. | European journal of pharmacology 20050321 |
| The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation. | The Journal of biological chemistry 20050311 |
| Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin. | The Journal of biological chemistry 20050304 |
| The hyperbilirubinemic Gunn rat is resistant to the pressor effects of angiotensin II. | American journal of physiology. Renal physiology 20050301 |
| BH(4) (tetrahydrobiopterin)-dependent activation, but not the expression, of inducible NOS (nitric oxide synthase)-2 in proinflammatory cytokine-stimulated, cultured normal human astrocytes is mediated by MEK-ERK kinases. | Journal of cellular biochemistry 20050301 |
| Treatment with tetrahydrobiopterin reduces blood pressure in male SHR by reducing testosterone synthesis. | American journal of physiology. Regulatory, integrative and comparative physiology 20050301 |
| Inhibition of vesicular monoamine transporter enhances vulnerability of dopaminergic cells: relevance to Parkinson's disease. | Neurochemistry international 20050301 |
| Tetrahydrobiopterin and eNOS dimer/monomer ratio--a clue to eNOS uncoupling in diabetes? | Cardiovascular research 20050301 |
| Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells. | Cardiovascular research 20050301 |
| Sex difference in nitric oxide synthase-dependent dilatation of cerebral arterioles during long-term alcohol consumption. | Alcoholism, clinical and experimental research 20050301 |
| Nitric oxide: a major determinant of mast cell phenotype and function. | Memorias do Instituto Oswaldo Cruz 20050301 |
| Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--a role for GFRP? | Free radical biology & medicine 20050215 |
| Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3. | Circulation research 20050204 |
| Transcribing the cross-talk of cytokine-induced tetrahydrobiopterin synthesis in endothelial cells. | Circulation research 20050204 |
| Exogenous NO suppresses flow-induced endothelium-derived NO production because of depletion of tetrahydrobiopterin. | American journal of physiology. Heart and circulatory physiology 20050201 |
| Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases. | The European journal of neuroscience 20050201 |
| Esrom, an ortholog of PAM (protein associated with c-myc), regulates pteridine synthesis in the zebrafish. | Developmental biology 20050115 |
| Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice. | Psychopharmacology 20050101 |
| Tetrahydrobiopterin restores impaired coronary microvascular dysfunction in hypercholesterolaemia. | European journal of nuclear medicine and molecular imaging 20050101 |
| Time-dependent inhibition and tetrahydrobiopterin depletion of endothelial nitric-oxide synthase caused by cigarettes. | Drug metabolism and disposition: the biological fate of chemicals 20050101 |
| Sepiapterin reductases from Chlorobium tepidum and Chlorobium limicola catalyze the synthesis of L-threo-tetrahydrobiopterin from 6-pyruvoyltetrahydropterin. | FEMS microbiology letters 20050101 |
| Estrogen modifies stress response of catecholamine biosynthetic enzyme genes and cardiovascular system in ovariectomized female rats. | Neuroscience 20050101 |
| Beneficial effect of tetrahydrobiopterin on the survival of rats exposed to hepatic ischemia-reperfusion injury. | Transplantation proceedings 20050101 |
| Systemic nitric oxide production rate during hemodialysis and its relationship with nitric oxide-related factors. | Blood purification 20050101 |
| Evidence for a tetrahydrobiopterin deficit in schizophrenia. | Neuropsychobiology 20050101 |
| Tetrahydrobiopterin as combined electron/proton donor in nitric oxide biosynthesis: cryogenic UV-Vis and EPR detection of reaction intermediates. | Methods in enzymology 20050101 |
| Platelet serotonin concentrations in PKU patients under dietary control and tetrahydrobiopterin treatment. | Journal of inherited metabolic disease 20050101 |
| Regulation of tyrosinase by tetrahydropteridines and H2O2. | Biochemical and biophysical research communications 20041224 |
| Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin. | American journal of physiology. Heart and circulatory physiology 20041201 |
| GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041201 |
| Tetrahydrobiopterin responsiveness in patients with phenylketonuria. | Clinical biochemistry 20041201 |
| Malfunction of vascular control in lifestyle-related diseases: endothelial nitric oxide (NO) synthase/NO system in atherosclerosis. | Journal of pharmacological sciences 20041201 |
| Evidence of cellular immune activation in children with opsoclonus-myoclonus: cerebrospinal fluid neopterin. | Journal of child neurology 20041201 |
| Alpha-Tocopherol and endothelial nitric oxide synthesis. | Annals of the New York Academy of Sciences 20041201 |
| Tetrahydrobiopterin protects phenylalanine hydroxylase activity in vivo: implications for tetrahydrobiopterin-responsive hyperphenylalaninemia. | FEBS letters 20041119 |
| Tetrahydrobiopterin binding to aromatic amino acid hydroxylases. Ligand recognition and specificity. | Journal of medicinal chemistry 20041118 |
| The effect of high glucose on NO and O2- through endothelial GTPCH1 and NADPH oxidase. | Life sciences 20041112 |
| Gene expression profiling of inflamed human endothelial cells and influence of activated protein C. | Circulation 20041102 |
| Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease. | American journal of physiology. Endocrinology and metabolism 20041101 |
| In vivo studies of phenylalanine hydroxylase by phenylalanine breath test: diagnosis of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency. | Pediatric research 20041101 |
| Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations. | Human mutation 20041101 |
| Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease. | Trends in cardiovascular medicine 20041101 |
| Thermodynamic characterization of the binding of tetrahydropterins to phenylalanine hydroxylase. | Journal of the American Chemical Society 20041027 |
| Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase. | Biochemistry 20041019 |
| Superoxide dismutase and catalase are required to detect (.-)NO from both coupled and uncoupled neuronal no synthase. | Free radical biology & medicine 20041001 |
| Reversible parkinsonism following heroin pyrolysate inhalation is associated with tetrahydrobiopterin deficiency. | Movement disorders : official journal of the Movement Disorder Society 20041001 |
| Tetrahydrobiopterin uptake in supplemental administration: elevation of tissue tetrahydrobiopterin in mice following uptake of the exogenously oxidized product 7,8-dihydrobiopterin and subsequent reduction by an anti-folate-sensitive process. | Journal of pharmacological sciences 20041001 |
| Substrate regulation of serotonin and dopamine synthesis in Drosophila. | Invertebrate neuroscience : IN 20041001 |
| Diffusion tensor images in children with early-treated, chronic, malignant phenylketonuric: correlation with intelligence assessment. | AJNR. American journal of neuroradiology 20041001 |
| Biology and chemistry of the inhibition of nitric oxide synthases by pteridine-derivatives as therapeutic agents. | Medicinal research reviews 20040901 |
| Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo. | Arteriosclerosis, thrombosis, and vascular biology 20040901 |
| Effect of chronic tetrahydrobiopterin supplementation on blood pressure and proteinuria in 5/6 nephrectomized rats. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040901 |
| Alpha-tocopherol amplifies phosphorylation of endothelial nitric oxide synthase at serine 1177 and its short-chain derivative trolox stabilizes tetrahydrobiopterin. | Free radical biology & medicine 20040901 |
| Comparison of tetrahydrobiopterin and L-arginine on cerebral blood flow after controlled cortical impact injury in rats. | Journal of neurotrauma 20040901 |
| [Mechanisms of nitric oxide production]. | Nihon rinsho. Japanese journal of clinical medicine 20040901 |
| [Diabetic macroangiopathy and NO]. | Nihon rinsho. Japanese journal of clinical medicine 20040901 |
| The effect of insufficiency of tetrahydrobiopterin on endothelial function and vasoactivity. | The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20040901 |
| Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH(4). | American journal of physiology. Heart and circulatory physiology 20040801 |
| Tetrahydrobiopterin rapidly reduces the SOD mimic Mn(III) ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin. | Free radical biology & medicine 20040801 |
| Tetrahydropteridines suppress gene expression and induce apoptosis of activated RAW264.7 cells via formation of hydrogen peroxide. | Free radical biology & medicine 20040801 |
| Trends in enzyme therapy for phenylketonuria. | Molecular therapy : the journal of the American Society of Gene Therapy 20040801 |
| Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin. | The Journal of biological chemistry 20040730 |
| Response of tyrosine hydroxylase and GTP cyclohydrolase I gene expression to estrogen in brain catecholaminergic regions varies with mode of administration. | Brain research 20040723 |
| Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder. | Biological psychiatry 20040715 |
| Functional tetrahydrobiopterin synthesis in human platelets. | Circulation 20040713 |
| Spectrophotometric analysis of the protective effect of ascorbate against spontaneous oxidation of tetrahydrobiopterin in aqueous solution: kinetic characteristics and potentiation by catalase of ascorbate action. | The international journal of biochemistry & cell biology 20040701 |
| Tetrahydrobiopterin improves endothelial dysfunction and vascular oxidative stress in microvessels of intrauterine undernourished rats. | The Journal of physiology 20040701 |
| Synergistic interaction between enalapril, L-arginine and tetrahydrobiopterin in smooth muscle cell apoptosis and aortic remodeling induction in SHR. | British journal of pharmacology 20040701 |
| Analysis of the kinetics of CO binding to neuronal nitric oxide synthase by flash photolysis: dual effects of substrates, inhibitors, and tetrahydrobiopterin. | Journal of inorganic biochemistry 20040701 |
| CO exchange of the oxyferrous complexes of endothelial nitric-oxide synthase oxygenase domain in the presence of 4-amino-tetrahydrobiopterin. | Journal of inorganic biochemistry 20040701 |
| Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse. | Molecular genetics and metabolism 20040701 |
| Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin. | Free radical biology & medicine 20040615 |
| Dysfunction of endothelial nitric oxide synthase and atherosclerosis. | Arteriosclerosis, thrombosis, and vascular biology 20040601 |
| The metabolic and molecular bases of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency. | Molecular genetics and metabolism 20040601 |
| Changes in the concentrations of tetrahydrobiopterin, the cofactor of tyrosine hydroxylase, in blood under physical stress and in depression. | Annals of the New York Academy of Sciences 20040601 |
| Reduced NOS3 phosphorylation mediates reduced NO/cGMP signaling in mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats. | Hypertension (Dallas, Tex. : 1979) 20040501 |
| Nitrotyrosine as a marker for peroxynitrite-induced neurotoxicity: the beginning or the end of the end of dopamine neurons? | Journal of neurochemistry 20040501 |
| 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide. | The Journal of biological chemistry 20040430 |
| Loss of striatal dopaminergic fibers after intraventricular injection of tetrahydrobiopterin in rat brain. | Neuroscience letters 20040408 |
| Inhibition of nuclear factor kappa B activation and inducible nitric oxide synthase transcription by prolonged exposure to high glucose in the human keratinocyte cell line HaCaT. | The British journal of dermatology 20040401 |
| Role of tetrahydrobiopterin in adrenocorticotropic hormone-induced hypertension in the rat. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20040401 |
| [Tetrahydrobiopterin and endothelial dysfunction]. | Sheng li ke xue jin zhan [Progress in physiology] 20040401 |
| Endothelial dysfunction in heart failure: mechanisms and therapeutic approaches. | Current vascular pharmacology 20040401 |
| Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease. | Arteriosclerosis, thrombosis, and vascular biology 20040301 |
| Long-term treatment and diagnosis of tetrahydrobiopterin-responsive hyperphenylalaninemia with a mutant phenylalanine hydroxylase gene. | Pediatric research 20040301 |
| Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. | Arteriosclerosis, thrombosis, and vascular biology 20040301 |
| Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin in the mouse hippocampus. | Neuropharmacology 20040301 |
| JNK activation by tetrahydrobiopterin: implication for Parkinson's disease. | Journal of neuroscience research 20040301 |
| Tetrahydrobiopterin: mediator of endothelial protection. | Arteriosclerosis, thrombosis, and vascular biology 20040301 |
| [Involvement of homocysteine in the pathogenesis of hypertension and hypertensive target-organ damage]. | Nihon rinsho. Japanese journal of clinical medicine 20040301 |
| [NO and hypertension]. | Nihon rinsho. Japanese journal of clinical medicine 20040301 |
| Tetrahydrobiopterin biosynthesis in white and brown adipose tissues is enhanced following intraperitoneal administration of bacterial lipopolysaccharide. | Biochimica et biophysica acta 20040224 |
| Indirect oxidation of 6-tetrahydrobiopterin by tyrosinase. | Biochemical and biophysical research communications 20040220 |
| Dynamic regulation of the inducible nitric-oxide synthase by NO: comparison with the endothelial isoform. | The Journal of biological chemistry 20040206 |
| In vivo expression and function of recombinant GTPCH I in the rabbit carotid artery. | American journal of physiology. Heart and circulatory physiology 20040201 |
| Long-term follow-up of a patient with mild tetrahydrobiopterin-responsive phenylketonuria. | Molecular genetics and metabolism 20040201 |
| More transgenic mouse models of dopamine deficiency. | Annals of neurology 20040201 |
| Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress. | The Journal of investigative dermatology 20040201 |
| Nuclear localization of tetrahydrobiopterin biosynthetic enzymes. | Biochimica et biophysica acta 20040105 |
| Activity of synthetic enzymes of tetrahydrobiopterin in the human placenta. | International journal of molecular medicine 20040101 |
| Glucocorticoids decrease GTP cyclohydrolase and tetrahydrobiopterin-dependent vasorelaxation through glucocorticoid receptors. | Journal of cardiovascular pharmacology 20040101 |
| Sepiapterin decreases vasorelaxation in nitric oxide synthase inhibition-induced hypertension. | Journal of cardiovascular pharmacology 20040101 |
| GTP cyclohydrolase I utilizes metal-free GTP as its substrate. | European journal of biochemistry 20040101 |
| New approaches to treat PKU: how far are we? | Molecular genetics and metabolism 20040101 |
| Plasma tetrahydrobiopterin and its pharmacokinetic following oral administration. | Molecular genetics and metabolism 20040101 |
| The fate of intravenously administered tetrahydrobiopterin and its implications for heterologous gene therapy of phenylketonuria. | Molecular genetics and metabolism 20040101 |
| Tetrahydrobiopterin deficiency and dopamine loss in a genetic mouse model of Lesch-Nyhan disease. | Journal of inherited metabolic disease 20040101 |
| Efficiency of long-term tetrahydrobiopterin monotherapy in phenylketonuria. | Journal of inherited metabolic disease 20040101 |
| The two faces of endothelial nitric oxide synthase in the pathophysiology of atherosclerosis. | Endothelium : journal of endothelial cell research 20040101 |
| Wild-type phenylalanine hydroxylase activity is enhanced by tetrahydrobiopterin supplementation in vivo: an implication for therapeutic basis of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency. | Molecular genetics and metabolism 20040101 |
| Tetrahydrobiopterin responsiveness: results of the BH4 loading test in 31 Spanish PKU patients and correlation with their genotype. | Molecular genetics and metabolism 20040101 |
| Regulation of tetrahydrobiopterin synthesis and bioavailability in endothelial cells. | Cell biochemistry and biophysics 20040101 |
| Radical reactions of nitric oxide synthases. | Biochemical Society symposium 20040101 |
| Tetrahydrobiopterin, a critical factor in the production and role of nitric oxide in mast cells. | The Journal of biological chemistry 20031212 |
| Utilization of exogenous tetrahydrobiopterin in nitric oxide synthesis in human neuroblastoma cell line. | Neuroscience letters 20031204 |
| Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways. | Biochemical Society transactions 20031201 |
| Bacterial translocation up-regulates GTP-cyclohydrolase I in mesenteric vasculature of cirrhotic rats. | Hepatology (Baltimore, Md.) 20031201 |
| Structural studies on phenylalanine hydroxylase and implications toward understanding and treating phenylketonuria. | Pediatrics 20031201 |
| Potential role of tetrahydrobiopterin in the treatment of maternal phenylketonuria. | Pediatrics 20031201 |
| Tetrahydrobiopterin and nitric oxide: mechanistic and pharmacological aspects. | Experimental biology and medicine (Maywood, N.J.) 20031201 |
| [Involvement of tetrahydrobiopterin in local change of endothelium-dependent vasorelaxation in pulmonary hypertension]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20031201 |
| A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase. | The Journal of biological chemistry 20031121 |
| Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity. | Biochemistry 20031118 |
| Critical role of interleukin-1beta for transcriptional regulation of endothelial 6-pyruvoyltetrahydropterin synthase. | Arteriosclerosis, thrombosis, and vascular biology 20031101 |
| Expression of phenylalanine hydroxylase (PAH) in erythrogenic bone marrow does not correct hyperphenylalaninemia in Pah(enu2) mice. | The journal of gene medicine 20031101 |
| cGMP inhibits GTP cyclohydrolase I activity and biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells. | Journal of pharmacological sciences 20031101 |
| 2.0A resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine: substrate specificity and molecular motions related to substrate binding. | Journal of molecular biology 20031031 |
| Ascorbate enhances iNOS activity by increasing tetrahydrobiopterin in RAW 264.7 cells. | Free radical biology & medicine 20031015 |
| Role of nitric oxide, tetrahydrobiopterin and peroxynitrite in glucose toxicity-associated contractile dysfunction in ventricular myocytes. | Diabetologia 20031001 |
| Tetrahydrobiopterin prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide. | Molecular pharmacology 20031001 |
| Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice. | British journal of pharmacology 20031001 |
| Genetic engineering of Escherichia coli for production of tetrahydrobiopterin. | Metabolic engineering 20031001 |
| Role of ascorbate in the regulation of nitric oxide generation by polymorphonuclear leukocytes. | Biochemical and biophysical research communications 20030912 |
| Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension. | Circulation 20030909 |
| Mechanism of aromatic hydroxylation by an activated FeIV=O core in tetrahydrobiopterin-dependent hydroxylases. | Chemistry (Weinheim an der Bergstrasse, Germany) 20030905 |
| Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. | The Journal of clinical investigation 20030901 |
| Immune function in children with classical phenylketonuria and tetrahydrobiopterin deficiencies. | Indian pediatrics 20030901 |
| Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members. | Archives of biochemistry and biophysics 20030815 |
| Low tetrahydrobiopterin biosynthetic capacity of human monocytes is caused by exon skipping in 6-pyruvoyl tetrahydropterin synthase. | The Biochemical journal 20030801 |
| Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects. | American journal of physiology. Heart and circulatory physiology 20030801 |
| Regulation of noradrenergic function by inflammatory cytokines and depolarization. | Journal of neurochemistry 20030801 |
| Exogenous biopterins requirement for iNOS function in vascular smooth muscle cells. | Journal of cardiovascular pharmacology 20030801 |
| Behavioral correction of Parkinsonian rats following the transplantation of immortalized fibroblasts genetically modified with TH and GCH genes. | Parkinsonism & related disorders 20030801 |
| Kainic acid lesion-induced nigral neuronal death. | Journal of chemical neuroanatomy 20030801 |
| Dwarfism and low insulin-like growth factor-1 due to dopamine depletion in Pts-/- mice rescued by feeding neurotransmitter precursors and H4-biopterin. | The Journal of biological chemistry 20030725 |
| Mechanism of systemically injected interferon-alpha impeding monoamine biosynthesis in rats: role of nitric oxide as a signal crossing the blood-brain barrier. | Brain research 20030718 |
| The autoxidation of tetrahydrobiopterin revisited. Proof of superoxide formation from reaction of tetrahydrobiopterin with molecular oxygen. | The Journal of biological chemistry 20030704 |
| Dopamine-dependent cytotoxicity of tetrahydrobiopterin: a possible mechanism for selective neurodegeneration in Parkinson's disease. | Journal of neurochemistry 20030701 |
| A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits. | Free radical biology & medicine 20030701 |
| Degeneration of the nigrostriatal pathway and induction of motor deficit by tetrahydrobiopterin: an in vivo model relevant to Parkinson's disease. | Neurobiology of disease 20030701 |
| A hypothesis on the biochemical mechanism of BH(4)-responsiveness in phenylalanine hydroxylase deficiency. | Amino acids 20030701 |
| [Recent advances in cardiac protection]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030701 |
| Physarum polycephalum expresses a dihydropteridine reductase with selectivity for pterin substrates with a 6-(1', 2'-dihydroxypropyl) substitution. | Biological chemistry 20030701 |
| Characterization of Drosophila nitric oxide synthase: a biochemical study. | Biochemical and biophysical research communications 20030627 |
| Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. | The Journal of biological chemistry 20030620 |
| Overexpression of V-1 prevents nitric oxide-induced cell death: involvement of enhanced tetrahydrobiopterin biosynthesis. | Journal of neuroscience research 20030615 |
| Probing cofactor specificity in phenylalanine hydroxylase by molecular dynamics simulations. | Journal of biomolecular structure & dynamics 20030601 |
| Involvement of apoptosis and calcium mobilization in tetrahydrobiopterin-induced dopaminergic cell death. | Experimental neurology 20030601 |
| Tetrahydrobiopterin radical enzymology. | Chemical reviews 20030601 |
| [Neural and molecular mechanisms of fatigue and recovery from fatigue]. | Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20030601 |
| Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells. | Free radical biology & medicine 20030515 |
| Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase: an in vitro demonstration in human coronary artery endothelial cells. | Circulation 20030513 |
| Novel inhibitors of neuronal nitric oxide synthase. | Experimental biology and medicine (Maywood, N.J.) 20030501 |
| Possible impact of tetrahydrobiopterin and sepiapterin on endothelial dysfunction. | Arteriosclerosis, thrombosis, and vascular biology 20030501 |
| [Structure-function relationships of NO synthase: electron transfer reaction]. | Seikagaku. The Journal of Japanese Biochemical Society 20030501 |
| Tetrahydrobiopterin attenuates homocysteine induced endothelial dysfunction. | Molecular and cellular biochemistry 20030501 |
| Tetrahydrobiopterin and mild phenylketonuria. | The New England journal of medicine 20030424 |
| Tetrahydrobiopterin and mild phenylketonuria. | The New England journal of medicine 20030424 |
| Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. | The Journal of clinical investigation 20030415 |
| Two modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron-N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining the binding mode. | Biochemistry 20030408 |
| Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 1-methyl-4-phenylpyridinium in nigral slice cultures. | Journal of neurochemistry 20030401 |
| Tetrahydrobiopterin sensitivity in German patients with mild phenylalanine hydroxylase deficiency. | Human mutation 20030401 |
| Induction of LOX-1 and iNOS expressions by ischemia-reperfusion of rat kidney and the opposing effect of L-arginine. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401 |
| Nitric oxide synthase induction, cGMP elevation, and biopterin synthesis in vascular smooth muscle cells stimulated with interleukin-1beta in hypoxia. | Journal of biochemistry 20030401 |
| [An eighteen-year study on phenylketonuria]. | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20030401 |
| Role of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolism. | Basic research in cardiology 20030301 |
| Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase. | European journal of biochemistry 20030301 |
| Tetrahydrobiopterin-responsive hyperphenylalaninaemia due to homozygous mutations in the phenylalanine hydroxylase gene. | European journal of pediatrics 20030301 |
| Stress and vascular responses: oxidative stress and endothelial dysfunction in the insulin-resistant state. | Journal of pharmacological sciences 20030301 |
| BH4-sensitive hyperphenylalaninemia: new case and review of literature. | Pediatric neurology 20030301 |
| New approaches to overcome tolerance to nitrates. | Cardiovascular drugs and therapy 20030301 |
| Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neurons. | Brain research 20030227 |
| Improvement by repeated administration of 6R-tetrahydrobiopterin of 5,7-dihydroxytryptamine-induced abnormal behaviors in immature rats. | Biochemical and biophysical research communications 20030227 |
| Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase. | Biochemistry 20030225 |
| Diminished production of nitric oxide synthase cofactor tetrahydrobiopterin by rosiglitazone in adipocytes. | Biochemical pharmacology 20030215 |
| Increased nitric oxide production and protection from malaria. | Lancet (London, England) 20030215 |
| Impairment of nitric oxide synthase-dependent dilatation of cerebral arterioles during infusion of nicotine. | American journal of physiology. Heart and circulatory physiology 20030201 |
| HMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 20030201 |
| Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency, state of the art. | Molecular genetics and metabolism 20030201 |
| Role of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts. | The Journal of cardiovascular surgery 20030201 |
| The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications. | Free radical research 20030201 |
| Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. | Circulation research 20030110 |
| Specific potentiation of endothelium-dependent contractions in SHR by tetrahydrobiopterin. | Hypertension (Dallas, Tex. : 1979) 20030101 |
| A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR. | Hypertension (Dallas, Tex. : 1979) 20030101 |
| Peripheral administration of lipopolysaccharide enhances the expression of guanosine triphosphate cyclohydrolase I mRNA in murine locus coeruleus. | Neuroscience 20030101 |
| Tetrahydrobiopterin control in phenylketonuria. | Genetics in medicine : official journal of the American College of Medical Genetics 20030101 |
| Lack of nitric oxide mediation of flow-dependent arteriolar dilation in type I diabetes is restored by sepiapterin. | Journal of vascular research 20030101 |
| Effect of tetrahydrobiopterin on blood pressure in rats after subtotal nephrectomy. | Nephron. Physiology 20030101 |
| Folic acid says NO to vascular diseases. | Nutrition (Burbank, Los Angeles County, Calif.) 20030101 |
| Danger of high-protein dietary supplements to persons with hyperphenylalaninaemia. | Journal of inherited metabolic disease 20030101 |
| Phenylketonuria detected by the neonatal screening program in Thailand. | The Southeast Asian journal of tropical medicine and public health 20030101 |
| 6-pyruvoyl tetrahydropterin synthase deficiency: a case report. | The Southeast Asian journal of tropical medicine and public health 20030101 |
| Tetrahydrobiopterin and dietary restriction in mild phenylketonuria. | The New England journal of medicine 20021226 |
| Tetrahydrobiopterin as an alternative treatment for mild phenylketonuria. | The New England journal of medicine 20021226 |
| Nitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting inducible NO synthase dimerization. | The Journal of biological chemistry 20021206 |
| High frequency of tetrahydrobiopterin-responsiveness among hyperphenylalaninemias: a study of 1,919 patients observed from 1988 to 2002. | Molecular genetics and metabolism 20021201 |
| Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201 |
| The antithyroid agent 6-n-propyl-2-thiouracil is a mechanism-based inactivator of the neuronal nitric oxide synthase isoform. | Archives of biochemistry and biophysics 20021101 |
| Developmental regulation of neurotransmitter phenotype through tetrahydrobiopterin. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20021101 |
| Effect of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats. | Critical care medicine 20021101 |
| The effect of insufficiency of tetrahydrobiopterin on endothelial function and vasoactivity. | The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20021101 |
| [Regulations and pathophysiological significance of the biosynthesis of tetrahydrobiopterin in human endothelial cells]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101 |
| [V-1, a catecholamine biosynthesis regulatory protein, enhances GTP cyclohydrolase I gene transcription in a cAMP-responsive element dependent manner]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101 |
| The role of tetrahydrobiopterin in the regulation of neuronal nitric-oxide synthase-generated superoxide. | The Journal of biological chemistry 20021025 |
| Characterization of quinonoid-dihydropteridine reductase (QDPR) from the lower eukaryote Leishmania major. | The Journal of biological chemistry 20021011 |
| Beneficial effect of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts. | The Journal of thoracic and cardiovascular surgery 20021001 |
| Sepiapterin treatment in atherosclerosis. | Arteriosclerosis, thrombosis, and vascular biology 20021001 |
| Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants. | Arteriosclerosis, thrombosis, and vascular biology 20021001 |
| Why do nitric oxide synthases use tetrahydrobiopterin? | Journal of inorganic biochemistry 20020920 |
| Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells. | The international journal of biochemistry & cell biology 20020901 |
| GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation. | Cardiovascular research 20020901 |
| Tetrahydrobiopterin deficiency increases neuronal vulnerability to hypoxia. | Journal of neurochemistry 20020901 |
| Glial cell line-derived neurotrophic factor up-regulates GTP-cyclohydrolase I activity and tetrahydrobiopterin levels in primary dopaminergic neurones. | Journal of neurochemistry 20020901 |
| Possible involvement of tetrahydrobiopterin in the trophic effect of insulin-like growth factor-1 on rat pheochromocytoma-12 (PC12) cells. | Neuroscience letters 20020809 |
| Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice. | The Journal of clinical investigation 20020801 |
| A 4-amino analogue of tetrahydrobiopterin attenuates endotoxin-induced hemodynamic alterations and organ injury in rats. | Shock (Augusta, Ga.) 20020801 |
| Oxidation of N-hydroxyguanidines by cytochromes P450 and NO-synthases and formation of nitric oxide. | Drug metabolism reviews 20020801 |
| Tetrahydrobiopterin responsiveness in a large series of phenylketonuria patients. | Journal of inherited metabolic disease 20020801 |
| Crystal structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its implications for the mechanism of catalysis and substrate activation. | Journal of molecular biology 20020726 |
| Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates. | Journal of molecular biology 20020712 |
| 6R-Tetrahydrobiopterin induces dopamine synthesis in a human neuroblastoma cell line, LA-N-1. A cellular model of DOPA-responsive dystonia. | Brain research 20020712 |
| Anti-inflammatory effects of tetrahydrobiopterin on early rejection in renal allografts: modulation of inducible nitric oxide synthase. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020701 |
| Tetrahydrobiopterin monotherapy for phenylketonuria patients with common mild mutations. | European journal of pediatrics 20020701 |
| Impaired vasodilation and nitric oxide synthase activity in glucocorticoid-induced hypertension. | Biological research for nursing 20020701 |
| Binding of L-arginine and imidazole suggests heterogeneity of rat brain neuronal nitric oxide synthase. | Biochemistry 20020618 |
| Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function. | American journal of physiology. Heart and circulatory physiology 20020601 |
| Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation: Identifying cellular targets for pharmacologic manipulation. | The Journal of thoracic and cardiovascular surgery 20020601 |
| Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells. | Biochemical and biophysical research communications 20020510 |
| Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin. | Brain research 20020510 |
| Direct evidence for nitric oxide production by a nitric-oxide synthase-like protein from Bacillus subtilis. | The Journal of biological chemistry 20020503 |
| Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability. | British journal of pharmacology 20020501 |
| Evaluation of basic performance and applicability of a newly developed in vivo nitric oxide sensor. | Physiological measurement 20020501 |
| Involvement of nitric oxide in glucose toxicity on differentiated PC12 cells: prevention of glucose toxicity by tetrahydrobiopterin, a cofactor for nitric oxide synthase. | Neuroscience research 20020501 |
| Interleukin-1beta-induced nitric oxide production and inhibition of insulin secretion in rat islets of langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin. | Cytokine 20020421 |
| Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells. | The Journal of biological chemistry 20020412 |
| Oxidative stress in vitiligo: photo-oxidation of pterins produces H(2)O(2) and pterin-6-carboxylic acid. | Biochemical and biophysical research communications 20020412 |
| Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. | Circulation 20020409 |
| Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals. | American journal of hypertension 20020401 |
| Biopterin analogues: novel nitric oxide synthase inhibitors with immunosuppressive action. | Current drug metabolism 20020401 |
| Disorders of tetrahydrobiopterin metabolism and their treatment. | Current drug metabolism 20020401 |
| Tetrahydrobiopterin in nitric oxide synthesis: a novel biological role for pteridines. | Current drug metabolism 20020401 |
| Tetrahydrobiopterin biosynthesis, utilization and pharmacological effects. | Current drug metabolism 20020401 |
| Pteridine derivatives as modulators of oxidative stress. | Current drug metabolism 20020401 |
| cAMP inhibits cytokine-induced biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells. | Life sciences 20020322 |
| The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study. | The Biochemical journal 20020315 |
| Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. | The Journal of clinical investigation 20020315 |
| Reactions catalyzed by the heme domain of inducible nitric oxide synthase: evidence for the involvement of tetrahydrobiopterin in electron transfer. | Biochemistry 20020312 |
| Nitric oxide (NO) traffic in endothelial NO synthase. Evidence for a new NO binding site dependent on tetrahydrobiopterin? | The Journal of biological chemistry 20020301 |
| Evaluation of 6-year application of the enzymatic colorimetric phenylalanine assay in the setting of neonatal screening for phenylketonuria. | Clinica chimica acta; international journal of clinical chemistry 20020301 |
| Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia. | Heart (British Cardiac Society) 20020301 |
| Glucose deprivation decreases nitric oxide production via NADPH depletion in immunostimulated rat primary astrocytes. | Glia 20020301 |
| Tetrahydrobiopterin improves impaired endothelium-dependent forearm vasodilation in patients with heart failure. | Journal of cardiovascular pharmacology 20020301 |
| Chemical stabilization of tetrahydrobiopterin by L-ascorbic acid: contribution to placental endothelial nitric oxide synthase activity. | Molecular human reproduction 20020301 |
| Evidence for a role of nitric oxide in the mediation of antiproliferative UVA effects in keratinocytes. | Pharmacological research 20020301 |
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| Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis. | Brain research. Molecular brain research 20020227 |
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| Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate. | Free radical biology & medicine 20020201 |
| Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency: possible regulation of gene expression in a patient with the homozygous L48S mutation. | Molecular genetics and metabolism 20020201 |
| Screening for tetrahydrobiopterin deficiency among hyperphenylalaninemia patients in Southern China. | Chinese medical journal 20020201 |
| Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer's disease. | Progress in neurobiology 20020201 |
| Tetrahydrobiopterin responsiveness in phenylketonuria. Two new cases and a review of molecular genetic findings. | Journal of inherited metabolic disease 20020201 |
| Nitrocatechols versus nitrocatecholamines as novel competitive inhibitors of neuronal nitric oxide synthase: lack of the aminoethyl side chain determines loss of tetrahydrobiopterin-antagonizing properties. | Bioorganic & medicinal chemistry letters 20020107 |
| Citrulline is not the major product using the standard 'NOS activity' assay on renal cortical homogenates. | American journal of physiology. Regulatory, integrative and comparative physiology 20020101 |
| Decreased plasma tetrahydrobiopterin in pregnant women is caused by impaired 6-pyruvoyl tetrahydropterin synthase activity. | International journal of molecular medicine 20020101 |
| Folates and cardiovascular disease. | Arteriosclerosis, thrombosis, and vascular biology 20020101 |
| Inhibition of N-methyl-D-aspartic acid-nitric oxide synthase in rat hippocampal slices by ethanol. Evidence for the involvement of tetrahydrobiopterin but not lipid peroxidation. | Journal of biomedical science 20020101 |
| Reduced nitric oxide metabolites in CSF of patients with tetrahydrobiopterin deficiency. | Journal of neurochemistry 20020101 |
| Tetrahydrobiopterin improves vascular endothelial function in ovariectomized rats. | Journal of biomedical science 20020101 |
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| Plasma biopterin levels and depressive state in pregnancy and the early puerperal period. | Neuropsychobiology 20020101 |
| Tetrahydrobiopterin improves coronary endothelial function, but does not prevent coronary spasm in patients with vasospastic angina. | Circulation journal : official journal of the Japanese Circulation Society 20020101 |
| Cranial MR spectroscopy of tetrahydrobiopterin deficiency. | AJNR. American journal of neuroradiology 20020101 |
| Redox role for tetrahydrobiopterin in nitric oxide synthase catalysis: low-temperature optical absorption spectral detection. | Methods in enzymology 20020101 |
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| Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin. | The Journal of biological chemistry 20011228 |
| Impaired endothelial regulation of ventricular relaxation in cardiac hypertrophy: role of reactive oxygen species and NADPH oxidase. | Circulation 20011211 |
| Tetrahydrobiopterin attenuates cholesterol induced coronary hyperreactivity to endothelin. | Heart (British Cardiac Society) 20011201 |
| Mechanisms of synergistic cytokine-induced nitric oxide production in human alveolar epithelial cells. | Nitric oxide : biology and chemistry 20011201 |
| Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress. | Journal of the American College of Cardiology 20011201 |
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| Oxidation of tetrahydrobiopterin by peroxynitrite or oxoferryl species occurs by a radical pathway. | Free radical research 20011201 |
| Treatment and outcome of Taiwanese patients with 6-pyruvoyltetrahydropterin synthase gene mutations. | Journal of inherited metabolic disease 20011201 |
| Involvement of tetrahydrobiopterin in trophic effect of erythropoietin on PC12 cells. | Biochemical and biophysical research communications 20011130 |
| High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin. | Journal of molecular biology 20011123 |
| Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism. | Biochemistry 20011113 |
| Intraplatelet tetrahydrobiopterin plays an important role in regulating canine coronary arterial thrombosis by modulating intraplatelet nitric oxide and superoxide generation. | Circulation 20011113 |
| Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice. | The Journal of biological chemistry 20011102 |
| Tetrahydrobiopterin, a cofactor for NOS, improves endothelial dysfunction during chronic alcohol consumption. | American journal of physiology. Heart and circulatory physiology 20011101 |
| Tetrahydrobiopterin-deficient hyperphenylalaninemia in the Chinese. | Clinica chimica acta; international journal of clinical chemistry 20011101 |
| Characterization of GTP cyclohydrolase I gene expression in the human neuroblastoma SKN-BE(2)M17: enhanced transcription in response to cAMP is conferred by the proximal promoter. | Journal of neurochemistry 20011101 |
| Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats. | Hypertension (Dallas, Tex. : 1979) 20011101 |
| Current strategies and perspectives for correcting endothelial dysfunction in atherosclerosis. | Journal of cardiovascular pharmacology 20011101 |
| A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin. | Biochemistry 20011030 |
| Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457. | Biochemistry 20011030 |
| Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical. | Free radical biology & medicine 20011015 |
| Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons. | The Journal of biological chemistry 20010914 |
| Treatable neurotransmitter deficiency in mild phenylketonuria. | Neurology 20010911 |
| Survival and graft function in a large animal lung transplant model after 30 h preservation and substitution of the nitric oxide pathway. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20010901 |
| Vascular endothelial dysfunction: does tetrahydrobiopterin play a role? | American journal of physiology. Heart and circulatory physiology 20010901 |
| Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells. | Japanese journal of pharmacology 20010901 |
| Molecular cloning and disruption of a novel gene encoding UDP-glucose: tetrahydrobiopterin alpha-glucosyltransferase in the cyanobacterium Synechococcus sp. PCC 7942. | FEBS letters 20010803 |
| Constitutive expression of ectopic c-Myc delays glucocorticoid-evoked apoptosis of human leukemic CEM-C7 cells. | Oncogene 20010802 |
| Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia. | American journal of human genetics 20010801 |
| Tetrahydrobiopterin levels regulate endothelial cell proliferation. | American journal of physiology. Heart and circulatory physiology 20010801 |
| Effects of tetrahydrobiopterin on ataxia in Machado-Joseph disease may be based upon the theory of 'cerebellar long-term depression'. | Medical hypotheses 20010801 |
| X-ray absorption spectroscopic analysis of the high-spin ferriheme site in substrate-bound neuronal nitric-oxide synthase. | Journal of biochemistry 20010801 |
| Tetrahydrobiopterin improves endothelial dysfunction in coronary microcirculation in patients without epicardial coronary artery disease. | Journal of the American College of Cardiology 20010801 |
| Determination of tetrahydrobiopterin in murine locus coeruleus by HPLC with fluorescence detection. | Brain research. Brain research protocols 20010801 |
| [Orphan drugs and metabolic disorders]. | Revista de neurologia 20010801 |
| Use of surface plasmon resonance for real-time measurements of the global conformational transition in human phenylalanine hydroxylase in response to substrate binding and catalytic activation. | Analytical biochemistry 20010715 |
| Tetrahydrobiopterin reverses the inhibition of nitric oxide by high glucose in cultured murine mesangial cells. | American journal of physiology. Renal physiology 20010701 |
| Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide? | Arteriosclerosis, thrombosis, and vascular biology 20010701 |
| Role of nitric oxide synthase in the light-induced development of sporangiophores in Phycomyces blakesleeanus. | Plant physiology 20010701 |
| Homomeric and heteromeric interactions between wild-type and mutant phenylalanine hydroxylase subunits: evaluation of two-hybrid approaches for functional analysis of mutations causing hyperphenylalaninemia. | Molecular genetics and metabolism 20010701 |
| Tetrahydrobiopterin: a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction? | American journal of physiology. Heart and circulatory physiology 20010601 |
| Hypoxia impairs endothelium-dependent relaxation in organ cultured pulmonary artery. | European journal of pharmacology 20010601 |
| Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency in Dutch neonates. | Journal of inherited metabolic disease 20010601 |
| Pterin interactions with distinct reductase activities of NO synthase. | The Biochemical journal 20010515 |
| Inhibition of neuronal nitric oxide synthase by 6-nitrocatecholamines, putative reaction products of nitric oxide with catecholamines under oxidative stress conditions. | The Biochemical journal 20010515 |
| Tetrahydrobiopterin augments arginine transport in rat cardiac myocytes through modulation of CAT-2 mRNA. | The Journal of laboratory and clinical medicine 20010501 |
| NO or H(2)O(2) for endothelium-dependent vasorelaxation: Tetrahydrobiopterin makes the difference. | Arteriosclerosis, thrombosis, and vascular biology 20010501 |
| Successful treatment of phenylketonuria with tetrahydrobiopterin. | European journal of pediatrics 20010501 |
| Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase. | The Journal of biological chemistry 20010427 |
| Important role of tetrahydrobiopterin in no complex formation and interdomain electron transfer in neuronal nitric-oxide synthase. | Biochemical and biophysical research communications 20010420 |
| Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin. | Science (New York, N.Y.) 20010413 |
| Thiouracil antithyroid drugs as a new class of neuronal nitric oxide synthase inhibitors. | Biochemical and biophysical research communications 20010406 |
| Ligand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexes. | Protein science : a publication of the Protein Society 20010401 |
| Electrochemistry of pterin cofactors and inhibitors of nitric oxide synthase. | Nitric oxide : biology and chemistry 20010401 |
| [Studies on neonatal screening, clinical and gene analysis for tetrahydrobiopterin deficiency in Southern Chinese]. | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20010401 |
| Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice. | Arteriosclerosis, thrombosis, and vascular biology 20010401 |
| Tetrahydrobiopterin reverses the impairment of acetylcholine-induced vasodilatation in diabetic ocular microvasculature. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010401 |
| A structural hypothesis for BH4 responsiveness in patients with mild forms of hyperphenylalaninaemia and phenylketonuria. | Journal of inherited metabolic disease 20010401 |
| Circulating tetrahydrobiopterin concentrations in patients with septic shock. | British journal of anaesthesia 20010401 |
| Tetrahydrobiopterin improves endothelium-dependent vasodilation in nitroglycerin-tolerant rats. | European journal of pharmacology 20010330 |
| Tetrahydrobiopterin enhances apoptotic PC12 cell death following withdrawal of trophic support. | The Journal of biological chemistry 20010323 |
| Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. | Circulation 20010306 |
| The cytotoxic effects of diesel exhaust particles on human pulmonary artery endothelial cells in vitro: role of active oxygen species. | Free radical biology & medicine 20010301 |
| Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts. | Clinical chemistry 20010301 |
| Effect of vitamin C on the availability of tetrahydrobiopterin in human endothelial cells. | Journal of cardiovascular pharmacology 20010301 |
| Differential nitric oxide synthase activity, cofactor availability and cGMP accumulation in the central nervous system during anaesthesia. | British journal of anaesthesia 20010301 |
| Tetrahydrobiopterin increases myocardial blood flow in healthy volunteers: a double-blind, placebo-controlled study. | Swiss medical weekly 20010224 |
| Kinetics of CO and NO ligation with the Cys(331)-->Ala mutant of neuronal nitric-oxide synthase. | The Journal of biological chemistry 20010216 |
| Expression of GTP cyclohydrolase I in murine locus ceruleus is enhanced by peripheral administration of lipopolysaccharide. | Brain research 20010202 |
| Tetrahydrobiopterin attenuates modulation of platelet 12-lipoxygenase and cyclooxygenase activities by nitric oxide. | Nitric oxide : biology and chemistry 20010201 |
| Paracrine neuroprotective effect of nitric oxide in the developing retina. | Journal of neurochemistry 20010201 |
| The optical interconversion of the P-450 and P-420 forms of neuronal nitric oxide synthase: effects of sodium cholate, mercury chloride and urea. | The international journal of biochemistry & cell biology 20010201 |
| Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity. | Chemical research in toxicology 20010201 |
| Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay. | Environmental health perspectives 20010201 |
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| Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase. | The Journal of biological chemistry 20010105 |
| L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin. | The Journal of biological chemistry 20010105 |
| Reconstitution of pterin-free inducible nitric-oxide synthase. | The Journal of biological chemistry 20010105 |
| Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase. | The international journal of biochemistry & cell biology 20010101 |
| Epidermal H(2)O(2) accumulation alters tetrahydrobiopterin (6BH4) recycling in vitiligo: identification of a general mechanism in regulation of all 6BH4-dependent processes? | The Journal of investigative dermatology 20010101 |
| CSF dopamine, serotonin, and biopterin metabolites in patients with restless legs syndrome. | Movement disorders : official journal of the Movement Disorder Society 20010101 |
| Prolonged survival of murine cardiac allografts by treatment with the 4-amino analog of tetrahydrobiopterin. | Transplantation proceedings 20010101 |
| Glucocorticoids inhibit tetrahydrobiopterin-dependent endothelial function. | Experimental biology and medicine (Maywood, N.J.) 20010101 |
| Parallel induction of nitric oxide and tetrahydrobiopterin synthesis in alveolar macrophages. | Respiration; international review of thoracic diseases 20010101 |
| Identification of three novel 6-pyruvoyl-tetrahydropterin synthase gene mutations (226C>T, IVS3+1G>A, 116-119delTGTT) in Chinese hyperphenylalaninemia caused by tetrahydrobiopterin synthesis deficiency. | Human mutation 20010101 |
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