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Home > Pyridines > 142-08-5

142-08-5

142-08-5 | Pyridinone

CAS No: 142-08-5 Catalog No: AG00HWA3 MDL No:MFCD00006268

Product Description

Catalog Number:
AG00HWA3
Chemical Name:
Pyridinone
CAS Number:
142-08-5
Molecular Formula:
C5H5NO
Molecular Weight:
95.0993
MDL Number:
MFCD00006268
IUPAC Name:
1H-pyridin-2-one
InChI:
InChI=1S/C5H5NO/c7-5-3-1-2-4-6-5/h1-4H,(H,6,7)
InChI Key:
UBQKCCHYAOITMY-UHFFFAOYSA-N
SMILES:
O=c1cccc[nH]1
UNII:
6770O3A2I5

Properties

Complexity:
135  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
95.037g/mol
Formal Charge:
0
Heavy Atom Count:
7  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
95.101g/mol
Monoisotopic Mass:
95.037g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
29.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.6  

Literature

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Inhibitory effect of pyridyloxy- or phenoxylphenoxyalkanate derivatives on rat lens aldose reductase and rat platelet aggregation. The Journal of pharmacy and pharmacology 20040701
Biradicals/zwitterions from thermolysis of enyne-isocyanates. Application to the synthesis of 2(1H)-pyridones, benzofuro[3,2-c]pyridin-1(2H)-ones, 2,5-dihydro-1H-pyrido[4,3-b]indol-1-ones, and related compounds. The Journal of organic chemistry 20040625
[Efficacy of the Russian anthelmintic agent trichlorophen]. Meditsinskaia parazitologiia i parazitarnye bolezni 20040101
Site-specific fluorescent labeling of RNA by a base-pair expanded transcription system. Nucleic acids symposium series (2004) 20040101
2(1H)-pyridinone (2-pyridone): self-association and association with water. Spectral and structural characteristics: infrared study and ab initio calculations. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20031201
Theoretical study of the ruthenium-catalyzed cyclocotrimerization of alkynes with isocyanates and iothiocyanates: cemoselective formation of pyridine-2-one and thiopyrane-2-imine. The Journal of organic chemistry 20031031
Design, synthesis, and crystal structure of selective 2-pyridone tissue factor VIIa inhibitors. Journal of medicinal chemistry 20031023
A flexible approach toward trisubstituted piperidines and indolizidines: synthesis of 6-epi-indolizidine 223A. The Journal of organic chemistry 20030530
[Impact of anthelminthic therapy for opisthorchiasis on the biochemical parameters of hepatic function]. Meditsinskaia parazitologiia i parazitarnye bolezni 20030101
An unnatural base pair for efficient incorporation of nucleotide analogs into RNAs. Nucleic acids research. Supplement (2001) 20030101
Simple preparation of biotinylated RNA by transcription via an unnatural base pair. Nucleic acids research. Supplement (2001) 20030101
2-Pyridone and 3-oxo-1,2,6-thiadiazine-1,1-dioxide derivatives: a new class of hydrogen bond equivalents of uracil. Journal of computer-aided molecular design 20030101
Hydrogen bond vibrations of 2-aminopyridine.2-pyridone, a Watson-Crick analogue of adenine.uracil. Journal of the American Chemical Society 20021204
A comparison of crop and non-crop plants as sensitive indicator species for regulatory testing. Pest management science 20021201
Stable oligonucleotide-directed triplex formation at target sites with CG interruptions: strong sequence-specific recognition by 2',4'-bridged nucleic-acid-containing 2-pyridones under physiological conditions. Chemistry (Weinheim an der Bergstrasse, Germany) 20021018
X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement. Biochemistry 20020903
Photochemistry of N-isopropoxy-substituted 2(1H)-pyridone and 4-p-tolylthiazole-2(3H)-thione: alkoxyl-radical release (spin-trapping, EPR, and transient spectroscopy) and its significance in the photooxidative induction of DNA strand breaks. The Journal of organic chemistry 20020823
Design and synthesis of novel inhibitors of gelatinase B. Bioorganic & medicinal chemistry letters 20020819
CYP1A1 induction by pyridine and its metabolites in HepG2 cells. Archives of biochemistry and biophysics 20020815
Stereoselective synthesis of 2,5,6-trisubstituted piperidines. Organic letters 20020613
Single crystal EPR of Cu(II) doped Cd(C5H5NO)6(BF4)2--an example of reduced metal hyperfine coupling constant. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20020501
Induction of CYP1A1 and CYP1A2 expressions by prototypic and atypical inducers in the human lung. Cancer letters 20020408
Imidazopyridinium and pyridopyrimidium bromides: synthesis and hydrolysis. The Journal of organic chemistry 20020405
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics. Bioorganic & medicinal chemistry letters 20020311
Influence of intermolecular hydrogen bonds on the tautomerism of pyridine derivatives. The Journal of organic chemistry 20020308
Molecular modeling analysis: 'Why is 2-hydroxypyridine soluble in water but not 3-hydroxypyridine?'. Journal of molecular modeling 20020301
Synthesis of an optically active, bicyclic 2-pyridone dipeptide mimetic. The Journal of organic chemistry 20020208
An unnatural base pair for incorporating amino acid analogs into proteins. Nature biotechnology 20020201
Solvent effects on the electronic absorption spectra and acid strength of some substituted pyridinols. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20020115
Design and parallel solid-phase synthesis of ring-fused 2-pyridinones that target pilus biogenesis in pathogenic bacteria. Journal of combinatorial chemistry 20020101
[Experience in treating cysticercosis of the brain with azinox]. Meditsinskaia parazitologiia i parazitarnye bolezni 20020101
An unnatural base pair between imidazolin-2-one and 2-amino-6-(2-thienyl)purine in replication and transcription. Nucleic acids research. Supplement (2001) 20020101
Inhibition of tyrosine phenol-lyase from Citrobacter freundii by 2-azatyrosine and 3-azatyrosine. Biochemistry 20011211
Infrared studies of tautomerism in 2-hydroxypyridine 2-thiopyridine and 2-aminopyridine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20011101
Rhodium-catalyzed asymmetric 1,4-addition of organoboron reagents to 5,6-dihydro-2(1H)-pyridinones. Asymmetric synthesis of 4-aryl-2-piperidinones. The Journal of organic chemistry 20011019
Unprecedented oxidation of a phenylglycinol-derived 2-pyridone: enantioselective synthesis of polyhydroxypiperidines. Organic letters 20011018
An enantioselective ketene-imine cycloaddition method for synthesis of substituted ring-fused 2-pyridinones. The Journal of organic chemistry 20011005
Pyridone annulation by 4 + 2 coupling of dienolates with nitriles and nitrile equivalents. A solution to the acetonitrile problem. The Journal of organic chemistry 20011005
Enzymatic synthesis of aza-l-tyrosines. Bioorganic & medicinal chemistry letters 20010820
Synthesis of 6-(2-thienyl)purine nucleoside derivatives that form unnatural base pairs with pyridin-2-one nucleosides. Bioorganic & medicinal chemistry letters 20010820
Cytotoxicity of 2-aldo- and 2-ketopyridine-N(4)-substituted thiosemicarbazones and mode of action in human Tmolt4 cells. Die Pharmazie 20010801
Hydrogen-bonded complexes of 2-pyridone with centrosymmetric and non-centrosymmetric dicarboxylic acids. Acta crystallographica. Section C, Crystal structure communications 20010501
Solid-state structure and solution behavior of eight-coordinate Sm(III) poly(pyrazolyl)borate compounds. Inorganic chemistry 20010312
A short stereoselective preparation of dienamides from cyclobutene compounds. Application in the synthesis of a new cyclohexene nucleoside. The Journal of organic chemistry 20010126
Oxodesmosine and isooxodesmosine, candidates of oxidative metabolic intermediates of pyridinium cross-links in elastin. Archives of biochemistry and biophysics 20010101
Synthesis and biological evaluation of pyridin-2-one nucleosides. Nucleosides, nucleotides & nucleic acids 20010101
Substitution mode of the amide fragment in some new N-[omega-[4-(2-methoxyphenyl)piperazin-1-yl]alkyl]pyrid-2(1H)-ones and their 5-HT1A/5-HT2A activity. Polish journal of pharmacology 20010101
Triplex formation involving 2',4'-BNA with 2-pyridone base analogue: efficient and selective recognition of C:G interruption. Nucleic acids research. Supplement (2001) 20010101
Structure-activity relationship of ligands of uracil phosphoribosyltransferase from Toxoplasma gondii. Biochemical pharmacology 19940817
Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogues. Journal of medicinal chemistry 19921016
2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors. Journal of medicinal chemistry 19910901

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