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Home > Other Building Blocks > 14199-63-4
14199-63-4 | 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-
CAS No: 14199-63-4 Catalog No: AG001HI1 MDL No:
Product Description
Catalog Number:
AG001HI1
Chemical Name:
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-
CAS Number:
14199-63-4
Molecular Formula:
C6H13NO4
Molecular Weight:
163.1717
IUPAC Name:
2-(hydroxymethyl)piperidine-3,4,5-triol
InChI:
InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2
InChI Key:
LXBIFEVIBLOUGU-UHFFFAOYSA-N
SMILES:
OCC1NCC(C(C1O)O)O
Properties
Complexity:
132
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
163.084g/mol
Formal Charge:
0
Heavy Atom Count:
11
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
5
Isotope Atom Count:
0
Molecular Weight:
163.173g/mol
Monoisotopic Mass:
163.084g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
93A^2
Undefined Atom Stereocenter Count:
4
Undefined Bond Stereocenter Count:
0
XLogP3:
-2.3
Literature
| Title | Journal |
|---|---|
| Hypoglycemic effect of deoxynojirimycin-polysaccharide on high fat diet and streptozotocin-induced diabetic mice via regulation of hepatic glucose metabolism. | Chemico-biological interactions 20150105 |
| 1-deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat-fed mice. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20150101 |
| Medium-chain dehydrogenases with new specificity: amino mannitol dehydrogenases on the azasugar biosynthetic pathway. | Protein and peptide letters 20140101 |
| Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. | Nature structural & molecular biology 20130701 |
| Miglustat-induced intestinal carbohydrate malabsorption is due to the inhibition of α-glucosidases, but not β-galactosidases. | Journal of inherited metabolic disease 20121101 |
| Oxidative stress in Niemann-Pick type C patients: a protective role of N-butyl-deoxynojirimycin therapy. | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20121001 |
| Initiation and discontinuation of substrate inhibitor treatment in patients with Niemann-Pick type C disease. | Gene 20120910 |
| Treatable metabolic psychoses that go undetected: what Niemann-Pick type C can teach us. | International journal of psychiatry in clinical practice 20120901 |
| Miglustat as a therapeutic agent: prospects and caveats. | Journal of medical genetics 20120901 |
| Intestinal alpha-glucosidase inhibitors: abdominal gas cysts. | Prescrire international 20120901 |
| α-Galactosidase aggregation is a determinant of pharmacological chaperone efficacy on Fabry disease mutants. | The Journal of biological chemistry 20120817 |
| Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition. | Chemistry (Weinheim an der Bergstrasse, Germany) 20120723 |
| Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection. | Journal of medicinal chemistry 20120712 |
| Alpha-glucosidase inhibitors 2012 - cardiovascular considerations and trial evaluation. | Diabetes & vascular disease research 20120701 |
| Differential effects of α-glucosidase inhibitors on postprandial plasma glucose and lipid profile in patients with type 2 diabetes under control with insulin lispro mix 50/50. | Diabetes technology & therapeutics 20120701 |
| Early miglustat therapy in infantile Niemann-Pick disease type C. | Pediatric neurology 20120701 |
| Deoxygenative olefination reaction as the key step in the syntheses of deoxy and iminosugars. | Chemistry (Weinheim an der Bergstrasse, Germany) 20120618 |
| Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin. | Acta diabetologica 20120601 |
| Unexpected cure from cutaneous leukocytoclastic vasculitis in a patient treated with N-butyldeoxynojirimycin (miglustat) for Gaucher disease. | Advances in medical sciences 20120601 |
| Potent α-glucosidase inhibitors from safflower (Carthamus tinctorius L.) seed. | Phytotherapy research : PTR 20120501 |
| Synergy between the pharmacological chaperone 1-deoxygalactonojirimycin and the human recombinant alpha-galactosidase A in cultured fibroblasts from patients with Fabry disease. | Journal of inherited metabolic disease 20120501 |
| A randomized placebo-controlled trial of miglustat in cystic fibrosis based on nasal potential difference. | Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20120501 |
| Effect of miglitol as an add-on to bolus insulin on postprandial glycemic excursions in type 2 diabetes patients assessed by continuous glucose monitoring. | Diabetes technology & therapeutics 20120501 |
| Miglustat improves purkinje cell survival and alters microglial phenotype in feline Niemann-Pick disease type C. | Journal of neuropathology and experimental neurology 20120501 |
| Synthesis of N-substituted ε-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease. | Organic & biomolecular chemistry 20120421 |
| Eight stereoisomers of homonojirimycin from D-mannose. | Organic letters 20120420 |
| Anorexigenic effects of miglitol in concert with the alterations of gut hormone secretion and gastric emptying in healthy subjects. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20120401 |
| Comparisons of the effects of 12-week administration of miglitol and voglibose on the responses of plasma incretins after a mixed meal in Japanese type 2 diabetic patients. | Diabetes, obesity & metabolism 20120301 |
| Substrate reduction therapy with miglustat for type 1 Gaucher disease: a retrospective analysis from a single institution. | Upsala journal of medical sciences 20120301 |
| Validated LC-MS/MS method for the quantitative determination of the glucosylceramide synthase inhibitor miglustat in mouse plasma and human plasma and its application to a pharmacokinetic study. | Journal of pharmaceutical and biomedical analysis 20120205 |
| Carboxymethylcellulose sodium improves the pharmacodynamics of 1-deoxynojirimycin by changing its absorption characteristics and pharmacokinetics in rats. | Die Pharmazie 20120201 |
| Extended remission of B-cell lymphoma with monoclonal gammopathy in a patient with type 1 Gaucher disease treated with enzyme replacement therapy. | Blood cells, molecules & diseases 20120115 |
| Crystal structure of human β-galactosidase: structural basis of Gm1 gangliosidosis and morquio B diseases. | The Journal of biological chemistry 20120113 |
| Pharmacological chaperone therapy for Fabry disease. | Proceedings of the Japan Academy. Series B, Physical and biological sciences 20120111 |
| Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation. | Metabolism: clinical and experimental 20120101 |
| Effect of 3-month repeated administration of miglitol on vascular endothelial function in patients with diabetes mellitus and coronary artery disease. | The American journal of cardiology 20120101 |
| Solution and gas-phase H/D exchange of protein-small-molecule complexes: Cex and its inhibitors. | Journal of the American Society for Mass Spectrometry 20120101 |
| An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseases. | Bioorganic & medicinal chemistry letters 20120101 |
| Effect of the α-glucosidase inhibitor miglitol on the glucose profile in Japanese type 2 diabetic patients receiving multiple daily insulin injections. | Endocrine journal 20120101 |
| Miglustat therapy in the French cohort of paediatric patients with Niemann-Pick disease type C. | Orphanet journal of rare diseases 20120101 |
| Successful treatment of reactive hypoglycemia secondary to late dumping syndrome using miglitol. | Internal medicine (Tokyo, Japan) 20120101 |
| Miglitol, an anti-diabetic drug, inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. | Journal of pharmacological sciences 20120101 |
| [Affect of deoxynojirimycin derivatives on hepatitis C virus morphogenesis]. | Molekuliarnaia biologiia 20120101 |
| The molecular basis of pharmacological chaperoning in human α-galactosidase. | Chemistry & biology 20111223 |
| Study of the inhibition of two human maltase-glucoamylases catalytic domains by different α-glucosidase inhibitors. | Carbohydrate research 20111213 |
| Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase. | Molecular pharmaceutics 20111205 |
| α-Glucosidase inhibition and antihyperglycemic activity of prenylated xanthones from Garcinia mangostana. | Phytochemistry 20111201 |
| Gaucher disease due to saposin C deficiency, previously described as non-neuronopathic form--no positive effects after 2-years of miglustat therapy. | Molecular genetics and metabolism 20111201 |
| Endoplasmic reticulum stress induces autophagy through activation of p38 MAPK in fibroblasts from Pompe disease patients carrying c.546G>T mutation. | Molecular genetics and metabolism 20111201 |
| Murine β-galactosidase stability is not dependent on temperature or protective protein/cathepsin A. | Molecular genetics and metabolism 20111201 |
| Treatment with the α-glucosidase inhibitor miglitol from the preonset stage in Otsuka Long-Evans Tokushima Fatty rats improves glycemic control and reduces the expression of inflammatory cytokine genes in peripheral leukocytes. | Metabolism: clinical and experimental 20111101 |
| Evaluation of miglustat treatment in patients with type III mucopolysaccharidosis: a randomized, double-blind, placebo-controlled study. | The Journal of pediatrics 20111101 |
| Canarene: a triterpenoid with a unique carbon skeleton from Canarium schweinfurthii. | Organic letters 20111021 |
| Amphiphilic 1-deoxynojirimycin derivatives through click strategies for chemical chaperoning in N370S Gaucher cells. | The Journal of organic chemistry 20111007 |
| Modulators of sphingolipid metabolism reduce lung inflammation. | American journal of respiratory cell and molecular biology 20111001 |
| Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111001 |
| Gastrointestinal disturbances and their management in miglustat-treated patients. | Journal of inherited metabolic disease 20111001 |
| Fusion failure of dense-cored proacrosomal vesicles in an inducible mouse model of male infertility. | Cell and tissue research 20111001 |
| [Report of attendance at the Parseghian Scientific Conference for Niemann-Pick Type C (NP-C) Research, South Bend, Indiana: in search of new therapeutic possibilities for a very rare illness]. | Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20111001 |
| Identification of a gene cluster that initiates azasugar biosynthesis in Bacillus amyloliquefaciens. | Chembiochem : a European journal of chemical biology 20110919 |
| 1-Deoxy-D-galactonojirimycins with dansyl capped N-substituents as β-galactosidase inhibitors and potential probes for GM1 gangliosidosis affected cell lines. | Carbohydrate research 20110906 |
| Both stimulation of GLP-1 receptors and inhibition of glycogenolysis additively contribute to a protective effect of oral miglitol against ischaemia-reperfusion injury in rabbits. | British journal of pharmacology 20110901 |
| Iminosugars as therapeutic agents: recent advances and promising trends. | Future medicinal chemistry 20110901 |
| [Guidelines for type 1 Gaucher's disease]. | Medicina clinica 20110901 |
| Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain. | Organic & biomolecular chemistry 20110807 |
| A pharmacogenetic approach to identify mutant forms of α-galactosidase A that respond to a pharmacological chaperone for Fabry disease. | Human mutation 20110801 |
| [Correlation of DNJ between taxilli herba and its host-plants]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801 |
| Intestinal glucose-induced calcium-calmodulin kinase signaling in the gut-brain axis in awake rats. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110701 |
| Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase. | Bioorganic & medicinal chemistry 20110701 |
| Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues. | Organic & biomolecular chemistry 20110607 |
| Treatment of fabry disease: current and emerging strategies. | Current pharmaceutical biotechnology 20110601 |
| Identification of the genes involved in 1-deoxynojirimycin synthesis in Bacillus subtilis MORI 3K-85. | Journal of microbiology (Seoul, Korea) 20110601 |
| Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase. | Organic & biomolecular chemistry 20110521 |
| Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization. | The Journal of biological chemistry 20110513 |
| A general method for affinity-based proteomic profiling of exo-α-glycosidases. | Chemical communications (Cambridge, England) 20110507 |
| Targeting enteral endocrinal L-cells with dietary carbohydrates, by increasing the availability of miglitol in the intestinal lumen, leads to multi-fold enhancement of plasma glucagon-like peptide-1 levels in non-diabetic canines. | Drug development and industrial pharmacy 20110501 |
| Comparison of 1-deoxynojirimycin and aqueous mulberry leaf extract with emphasis on postprandial hypoglycemic effects: in vivo and in vitro studies. | Journal of agricultural and food chemistry 20110413 |
| Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice. | Journal of ethnopharmacology 20110412 |
| Ultra-performance liquid chromatography electrospray ionization-tandem mass spectrometry method for the estimation of miglitol in human plasma using metformin as the internal standard. | Drug testing and analysis 20110401 |
| Efficacy of combined use of miglitol in Type 2 diabetes patients receiving insulin therapy-placebo-controlled double-blind comparative study. | Acta diabetologica 20110301 |
| Evaluation of the efficacy and tolerability of miglitol in Chinese patients with type 2 diabetes mellitus inadequately controlled by diet and sulfonylureas. | Acta diabetologica 20110301 |
| Comparing the efficacy of α-glucosidase inhibitors in suppressing postprandial hyperglycemia using continuous glucose monitoring: a pilot study-the MAJOR study. | Diabetes technology & therapeutics 20110301 |
| The videofluoroscopic swallowing study shows a sustained improvement of dysphagia in children with Niemann-Pick disease type C after therapy with miglustat. | American journal of medical genetics. Part A 20110301 |
| Elevated serum levels of interleukin-18 in patients with overt diabetic nephropathy: effects of miglitol. | Clinical and experimental nephrology 20110201 |
| Increased globotriaosylceramide levels in a transgenic mouse expressing human alpha1,4-galactosyltransferase and a mouse model for treating Fabry disease. | Journal of biochemistry 20110201 |
| Gamma-secretase-dependent amyloid-beta is increased in Niemann-Pick type C: a cross-sectional study. | Neurology 20110125 |
| Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold. | Bioorganic & medicinal chemistry letters 20110115 |
| Treatment of cataplexy in Niemann-Pick disease type C with the use of miglustat. | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20110101 |
| Effects of miglitol in combination with intensive insulin therapy on blood glucose control with special reference to incretin responses in type 1 diabetes mellitus. | Endocrine journal 20110101 |
| Glycosphingolipids and insulin resistance. | Advances in experimental medicine and biology 20110101 |
| Therapy of Fabry disease with pharmacological chaperones: from in silico predictions to in vitro tests. | Orphanet journal of rare diseases 20110101 |
| Effect of environmental conditions on the α-glucosidase inhibitory activity of mulberry leaves. | Bioscience, biotechnology, and biochemistry 20110101 |
| Corneal alterations during combined therapy with cyclodextrin/allopregnanolone and miglustat in a knock-out mouse model of NPC1 disease. | PloS one 20110101 |
| A pilot study of the efficacy of miglitol and sitagliptin for type 2 diabetes with a continuous glucose monitoring system and incretin-related markers. | Cardiovascular diabetology 20110101 |
| Molecular basis of reduced glucosylceramidase activity in the most common Gaucher disease mutant, N370S. | The Journal of biological chemistry 20101231 |
| N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells. | Bioorganic & medicinal chemistry letters 20101215 |
| Synthesis of all-cis 2,5-imino-2,5-dideoxy-fucitol and its evaluation as a potent fucosidase and galactosidase inhibitor. | Bioorganic & medicinal chemistry letters 20101215 |
| Syntheses of the enantiomers of 1-deoxynojirimycin and 1-deoxyaltronojirimycin via chemo- and diastereoselective olefinic oxidation of unsaturated amines. | The Journal of organic chemistry 20101203 |
| The α-glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes mellitus. | Metabolism: clinical and experimental 20101201 |
| The pathophysiology of GD - current understanding and rationale for existing and emerging therapeutic approaches. | Wiener medizinische Wochenschrift (1946) 20101201 |
| A Fluorescent sp2-iminosugar with pharmacological chaperone activity for gaucher disease: synthesis and intracellular distribution studies. | Chembiochem : a European journal of chemical biology 20101122 |
| Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative. | Bioorganic & medicinal chemistry 20101115 |
| Molecular characterization of plant acidic alpha-mannosidase, a member of glycosylhydrolase family 38, involved in the turnover of N-glycans during tomato fruit ripening. | Journal of biochemistry 20101101 |
| Fluorescent-tagged sp2-iminosugars with potent β-glucosidase inhibitory activity. | Bioorganic & medicinal chemistry 20101101 |
| Changes in α-glucosidase activities along the jejunal-ileal axis of normal rats by the α-glucosidase inhibitor miglitol. | Metabolism: clinical and experimental 20101001 |
| Novel method for chase analysis of oligosaccharide metabolic error caused by xenobiotics. | Analytical biochemistry 20101001 |
| Glucosidase inhibition enhances presentation of de-N-glycosylated hepatitis B virus epitopes by major histocompatibility complex class I in vitro and in woodchucks. | Hepatology (Baltimore, Md.) 20101001 |
| Enantioselective and protecting group-free synthesis of 1-deoxythionojirimycin, 1-deoxythiomannojirimycin, and 1-deoxythiotalonojirimycin. | The Journal of organic chemistry 20101001 |
| Amplification of the inhibitory activity and reversal of the selectivity of miglitol by C(2')-monofluorination. | Archiv der Pharmazie 20101001 |
| Determination of iminosugars in mulberry leaves and silkworms using hydrophilic interaction chromatography-tandem mass spectrometry. | Analytical biochemistry 20100915 |
| Synthesis of L-altro-1-deoxynojirimycin, D-allo-1-deoxynojirimycin, and D-galacto-1-deoxynojirimycin from a single chiral cyanohydrin. | Organic letters 20100903 |
| A membrane-bound trehalase from Chironomus riparius larvae: purification and sensitivity to inhibition. | Glycobiology 20100901 |
| Deoxynojirimycin and its hexosaminyl derivatives bind to natural killer cell receptors rNKR-P1A and hCD69. | Bioorganic & medicinal chemistry letters 20100801 |
| How adhesion/growth-regulatory galectins-1 and -3 attain cell specificity: case study defining their target on neuroblastoma cells (SK-N-MC) and marked affinity regulation by affecting microdomain organization of the membrane. | IUBMB life 20100801 |
| C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation. | The Journal of biological chemistry 20100716 |
| 1-Deoxynojirimycins with dansyl capped N-substituents as probes for Morbus Gaucher affected cell lines. | Carbohydrate research 20100702 |
| DLHex-DGJ, a novel derivative of 1-deoxygalactonojirimycin with pharmacological chaperone activity in human G(M1)-gangliosidosis fibroblasts. | Molecular genetics and metabolism 20100701 |
| Single administration of alpha-glucosidase inhibitors on endothelial function and incretin secretion in diabetic patients with coronary artery disease - Juntendo University trial: effects of miglitol on endothelial vascular reactivity in type 2 diabetic patients with coronary heart disease (J-MACH) -. | Circulation journal : official journal of the Japanese Circulation Society 20100701 |
| Comparison of absorption of 1-deoxynojirimycin from mulberry water extract in rats. | Journal of agricultural and food chemistry 20100609 |
| Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice. | Journal of neurochemistry 20100601 |
| Biological study of the angiogenesis inhibitor N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin. | Chemical biology & drug design 20100601 |
| [Clinical diagnosis of the adult form of Niemann-Pick type C disease]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20100601 |
| [Therapies in the Niemann-Pick type C disease]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20100601 |
| Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice. | Arteriosclerosis, thrombosis, and vascular biology 20100501 |
| Purification and identification of 1-deoxynojirimycin (DNJ) in okara fermented by Bacillus subtilis B2 from Chinese traditional food (Meitaoza). | Journal of agricultural and food chemistry 20100414 |
| Changes in the atherogenic profile of patients with type 1 Gaucher disease after miglustat therapy. | Atherosclerosis 20100401 |
| Miglustat in adult and juvenile patients with Niemann-Pick disease type C: long-term data from a clinical trial. | Molecular genetics and metabolism 20100401 |
| Entamoeba histolytica: identification and partial characterization of alpha-mannosidase activity. | Experimental parasitology 20100401 |
| Clinical experience with miglustat therapy in pediatric patients with Niemann-Pick disease type C: a case series. | Molecular genetics and metabolism 20100401 |
| A case of insulinoma following total gastrectomy--effects of an alpha-glucosidase inhibitor on suppressing GIP and GLP-1 elevations. | Diabetes research and clinical practice 20100401 |
| Lysosomal storage of oligosaccharide and glycosphingolipid in imino sugar treated cells. | Glycoconjugate journal 20100401 |
| Accumulation of 1-deoxynojirimycin in silkworm, Bombyx mori L. | Journal of Zhejiang University. Science. B 20100401 |
| Simple, selective, and rapid quantification of 1-deoxynojirimycin in mulberry leaf products by high-performance anion-exchange chromatography with pulsed amperometric detection. | Journal of food science 20100401 |
| Short and straightforward synthesis of (-)-1-deoxygalactonojirimycin. | Organic letters 20100319 |
| Long-term miglustat therapy in children with Niemann-Pick disease type C. | Journal of child neurology 20100301 |
| Eye movement and diffusion tensor imaging analysis of treatment effects in a Niemann-Pick Type C patient. | Molecular genetics and metabolism 20100301 |
| Glucose supply and insulin demand dynamics of antidiabetic agents. | Journal of diabetes science and technology 20100301 |
| Development and validation of HPLC-UV-MS method for the control of four anti-diabetic drugs in suspected counterfeit products. | Yao xue xue bao = Acta pharmaceutica Sinica 20100301 |
| Force majeure: therapeutic measures in response to restricted supply of imiglucerase (Cerezyme) for patients with Gaucher disease. | Blood cells, molecules & diseases 20100115 |
| The pharmacological chaperone 1-deoxygalactonojirimycin reduces tissue globotriaosylceramide levels in a mouse model of Fabry disease. | Molecular therapy : the journal of the American Society of Gene Therapy 20100101 |
| An oxidation and ring contraction approach to the synthesis of (+/-)-1-deoxynojirimycin and (+/-)-1-deoxyaltronojirimycin. | Organic letters 20100101 |
| Structural basis of alpha-fucosidase inhibition by iminocyclitols with K(i) values in the micro- to picomolar range. | Angewandte Chemie (International ed. in English) 20100101 |
| Effects of miglitol, sitagliptin or their combination on plasma glucose, insulin and incretin levels in non-diabetic men. | Endocrine journal 20100101 |
| Effects of pre-meal versus post-meal administration of miglitol on plasma glucagon-like peptide-1 and glucosedependent insulinotropic polypeptide levels in healthy men. | Endocrine journal 20100101 |
| Niemann-Pick disease type C. | Orphanet journal of rare diseases 20100101 |
| Comparison of adverse gastrointestinal effects of acarbose and miglitol in healthy men: a crossover study. | Internal medicine (Tokyo, Japan) 20100101 |
| Oxidative stress in Niemann-Pick disease, type C. | Molecular genetics and metabolism 20100101 |
| Pneumatosis cystoides intestinalis induced by the α-glucosidase inhibitor miglitol. | Internal medicine (Tokyo, Japan) 20100101 |
| Prediction of the responsiveness to pharmacological chaperones: lysosomal human alpha-galactosidase, a case of study. | Orphanet journal of rare diseases 20100101 |
| Reduced expression of β2 integrin genes in rat peripheral leukocytes by inhibiting postprandial hyperglycemia. | Bioscience, biotechnology, and biochemistry 20100101 |
| Silkworm pupae (Bombyx mori) are new sources of high quality protein and lipid. | Journal of nutritional science and vitaminology 20100101 |
| The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats. | European journal of pharmacology 20091210 |
| Real-world clinical experience with long-term miglustat maintenance therapy in type 1 Gaucher disease: the ZAGAL project. | Haematologica 20091201 |
| The pharmacological chaperone 1-deoxynojirimycin increases the activity and lysosomal trafficking of multiple mutant forms of acid alpha-glucosidase. | Human mutation 20091201 |
| Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2. | The FEBS journal 20091201 |
| Optimization of 1-deoxynojirimycin extraction from mulberry leaves by using response surface methodology. | Bioscience, biotechnology, and biochemistry 20091201 |
| [Treatment of bone involvement in Gaucher diseases with imiglucerase combined with miglustat]. | Presse medicale (Paris, France : 1983) 20091201 |
| Intake of 1-deoxynojirimycin suppresses lipid accumulation through activation of the beta-oxidation system in rat liver. | Journal of agricultural and food chemistry 20091125 |
| Chaperone activity of bicyclic nojirimycin analogues for Gaucher mutations in comparison with N-(n-nonyl)deoxynojirimycin. | Chembiochem : a European journal of chemical biology 20091123 |
| Miglustat in patients with Niemann-Pick disease Type C (NP-C): a multicenter observational retrospective cohort study. | Molecular genetics and metabolism 20091101 |
| Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice. | Hepatology (Baltimore, Md.) 20091101 |
| Phytochemical profiles of different mulberry (Morus sp.) species from China. | Journal of agricultural and food chemistry 20091014 |
| Design and evaluation of oral bioadhesive controlled release formulations of miglitol, intended for prolonged inhibition of intestinal alpha-glucosidases and enhancement of plasma glucagon like peptide-1 levels. | International journal of pharmaceutics 20091001 |
| Amplification of the inhibitory activity of miglitol by monofluorination. | Bioorganic & medicinal chemistry letters 20091001 |
| Miglustat (Zavesca) in type 1 Gaucher disease: 5-year results of a post-authorisation safety surveillance programme. | Pharmacoepidemiology and drug safety 20090901 |
| Synthesis of polyfunctional quinolizidine alkaloids: development towards selective glycosidase inhibitors. | Organic & biomolecular chemistry 20090821 |
| Raffinose and stachyose metabolism are not required for efficient soybean seed germination. | Journal of plant physiology 20090815 |
| A cystic fibrosis respiratory epithelial cell chronically treated by miglustat acquires a non-cystic fibrosis-like phenotype. | American journal of respiratory cell and molecular biology 20090801 |
| Pharmacokinetics, safety and tolerability of miglustat in the treatment of pediatric patients with GM2 gangliosidosis. | Molecular genetics and metabolism 20090801 |
| Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase. | Analytical and bioanalytical chemistry 20090801 |
| The alpha-glucosidase inhibitor miglitol suppresses postprandial hyperglycaemia and interleukin-1beta and tumour necrosis factor-alpha gene expression in rat peripheral leucocytes induced by intermittent sucrose loading. | The British journal of nutrition 20090701 |
| Impact of glycosylation and detergent-resistant membranes on the function of intestinal sucrase-isomaltase. | Biological chemistry 20090701 |
| Structural determinants of product specificity of sucrose isomerases. | FEBS letters 20090618 |
| 6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase. | Chembiochem : a European journal of chemical biology 20090615 |
| Organocatalytic syn-aldol reactions of dioxanones with (S)-isoserinal hydrate: synthesis of L-deoxymannojirimycin and L-deoxyidonojirimycin. | The Journal of organic chemistry 20090605 |
| The alpha-glucosidase inhibitor miglitol decreases glucose fluctuations and gene expression of inflammatory cytokines induced by hyperglycemia in peripheral leukocytes. | Nutrition (Burbank, Los Angeles County, Calif.) 20090601 |
| The pharmacological chaperone N-butyldeoxynojirimycin enhances enzyme replacement therapy in Pompe disease fibroblasts. | Molecular therapy : the journal of the American Society of Gene Therapy 20090601 |
| Airway delivery of low-dose miglustat normalizes nasal potential difference in F508del cystic fibrosis mice. | American journal of respiratory and critical care medicine 20090601 |
| Miglustat in late-onset Tay-Sachs disease: a 12-month, randomized, controlled clinical study with 24 months of extended treatment. | Genetics in medicine : official journal of the American College of Medical Genetics 20090601 |
| The pharmacological chaperone 1-deoxygalactonojirimycin increases alpha-galactosidase A levels in Fabry patient cell lines. | Journal of inherited metabolic disease 20090601 |
| A stereocontrolled synthesis of 3-acetamido-1,3,5-trideoxy- and 1,3,5,6-tetradeoxy-1,5-imino-D-glucitol. | Carbohydrate research 20090526 |
| Glucosylceramide synthase inhibitors sensitise CLL cells to cytotoxic agents without reversing P-gp functional activity. | European journal of pharmacology 20090501 |
| Synthesis and biological characterisation of novel N-alkyl-deoxynojirimycin alpha-glucosidase inhibitors. | Chembiochem : a European journal of chemical biology 20090417 |
| [Recent therapeutics for Fabry disease]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20090410 |
| Molecular interaction of imino sugars with human alpha-galactosidase: Insight into the mechanism of complex formation and pharmacological chaperone action in Fabry disease. | Molecular genetics and metabolism 20090401 |
| Expeditious synthesis of a common intermediate of L-1-deoxyallonojirimycin and L-1-deoxymannojirimycin. | The Journal of organic chemistry 20090306 |
| Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090301 |
| Preclinical efficacy and safety of 1-deoxygalactonojirimycin in mice for Fabry disease. | The Journal of pharmacology and experimental therapeutics 20090301 |
| [Quantitative determination of 1-deoxynojirimycin in mulberry leaves by high-performance liquid chromatographic-tandem mass/mass spectrometry]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090301 |
| A short and convenient synthesis of 1-deoxymannojirimycin and N-oxy analogues from D-fructose. | The Journal of organic chemistry 20090220 |
| Deoxynojirimycin enhanced the transglycosylation activity of a glycosidase from the China white jade snail. | Journal of biotechnology 20090205 |
| 24 month-treatment with miglustat of three patients with Niemann-Pick disease type C: follow up using brain spectroscopy. | Molecular genetics and metabolism 20090201 |
| Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice. | Hepatology (Baltimore, Md.) 20090201 |
| Miglitol induces prolonged and enhanced glucagon-like peptide-1 and reduced gastric inhibitory polypeptide responses after ingestion of a mixed meal in Japanese Type 2 diabetic patients. | Diabetic medicine : a journal of the British Diabetic Association 20090201 |
| [Chemical constituents from Polygala telephioides]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201 |
| [Study on changes of contents of 1-deoxynojirimycin in Bombyx mori and their byproducts]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090201 |
| Effects of a chemical chaperone on genetic mutations in alpha-galactosidase A in Korean patients with Fabry disease. | Experimental & molecular medicine 20090131 |
| Multivalent iminosugars to modulate affinity and selectivity for glycosidases. | Organic & biomolecular chemistry 20090121 |
| Rapid quantification of miglustat in human plasma and cerebrospinal fluid by liquid chromatography coupled with tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090115 |
| Effect of insulin-unstimulated diabetic therapy with miglitol on serum cystatin C level and its clinical significance. | Diabetes research and clinical practice 20090101 |
| Inhibition of alpha-mannosidase attenuates endoplasmic reticulum stress-induced neuronal cell death. | Neurotoxicology 20090101 |
| Class II alpha-mannosidase from Aspergillus fischeri: energetics of catalysis and inhibition. | International journal of biological macromolecules 20090101 |
| Promising results of the chaperone effect caused by imino sugars and aminocyclitol derivatives on mutant glucocerebrosidases causing Gaucher disease. | Blood cells, molecules & diseases 20090101 |
| Goal-oriented therapy with miglustat in Gaucher disease. | Current medical research and opinion 20090101 |
| Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation. | PloS one 20090101 |
| Substrate reduction therapy in juvenile GM2 gangliosidosis. | Molecular genetics and metabolism 20090101 |
| Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression. | PloS one 20090101 |
| Pharmacological chaperone therapy by active-site-specific chaperones in Fabry disease: in vitro and preclinical studies. | International journal of clinical pharmacology and therapeutics 20090101 |
| 1-Deoxygalactonojirimycin-lysine hybrids as potent D-galactosidase inhibitors. | Bioorganic & medicinal chemistry 20081215 |
| Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel. | Hepatology (Baltimore, Md.) 20081201 |
| Treatment of a child diagnosed with Niemann-Pick disease type C with miglustat: a case report in Brazil. | Journal of inherited metabolic disease 20081201 |
| Synthesis of iminoalditol analogues of galactofuranosides and their activities against glycosidases. | Carbohydrate research 20081124 |
| Anti-inflammatory effect of miglustat in bronchial epithelial cells. | Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20081101 |
| Randomized, controlled trial of miglustat in Gaucher's disease type 3. | Annals of neurology 20081101 |
| Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated injury. | Journal of neuroimmunology 20081015 |
| Novel anti-adherence activity of mulberry leaves: inhibition of Streptococcus mutans biofilm by 1-deoxynojirimycin isolated from Morus alba. | The Journal of antimicrobial chemotherapy 20081001 |
| N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery. | AIDS (London, England) 20081001 |
| New access to 1-deoxynojirimycin derivatives via azide-alkene cycloaddition. | Organic letters 20080904 |
| The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells. | The Journal of pharmacology and experimental therapeutics 20080901 |
| Prediction of response of mutated alpha-galactosidase A to a pharmacological chaperone. | Pharmacogenetics and genomics 20080901 |
| Miglitol suppresses the postprandial increase in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects. | Metabolism: clinical and experimental 20080901 |
| Comparison of pre- vs. postmeal administration of miglitol for 3 months in type 2 diabetic patients. | Diabetes, obesity & metabolism 20080901 |
| [Determination of 1-deoxynojirimycin in Morus alba L. leaves using reversed-phase high performance liquid chromatography fluorescence detection with pre-column derivatization]. | Se pu = Chinese journal of chromatography 20080901 |
| Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: application to pharmacokinetic studies. | Bioscience, biotechnology, and biochemistry 20080801 |
| Synthesis of somatostatin mimetics based on 1-deoxynojirimycin. | ChemMedChem 20080701 |
| Changes of bone metabolism in seven patients with Gaucher disease treated consecutively with imiglucerase and miglustat. | Calcified tissue international 20080701 |
| Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis. | Bioorganic & medicinal chemistry 20080615 |
| Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells. | The Journal of pharmacology and experimental therapeutics 20080601 |
| Splenic nodules in paediatric Gaucher disease treated by enzyme replacement therapy. | Pediatric radiology 20080601 |
| Rescue of mutant alpha-galactosidase A in the endoplasmic reticulum by 1-deoxygalactonojirimycin leads to trafficking to lysosomes. | Biochimica et biophysica acta 20080601 |
| Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis. | Molecular genetics and metabolism 20080601 |
| Differential sensitivity of mouse strains to an N-alkylated imino sugar: glycosphingolipid metabolism and acrosome formation. | Pharmacogenomics 20080601 |
| Cell surface associated alpha-L-fucose moieties modulate human breast cancer neoplastic progression. | Pathology oncology research : POR 20080601 |
| Beta-fructofuranosidase genes of the silkworm, Bombyx mori: insights into enzymatic adaptation of B. mori to toxic alkaloids in mulberry latex. | The Journal of biological chemistry 20080530 |
| Regioselective intramolecular ring closure of 2-amino-6-bromo-2,6-dideoxyhexono-1,4-lactones to 5- or 6-membered iminuronic acid analogues: synthesis of 1-deoxymannojirimycin and 2,5-dideoxy-2,5-imino-D-glucitol. | Organic & biomolecular chemistry 20080521 |
| N-butyldeoxygalactonojirimycin reduces brain ganglioside and GM2 content in neonatal Sandhoff disease mice. | Neurochemistry international 20080501 |
| Binding parameters and thermodynamics of the interaction of imino sugars with a recombinant human acid alpha-glucosidase (alglucosidase alfa): insight into the complex formation mechanism. | Clinica chimica acta; international journal of clinical chemistry 20080501 |
| Antiobesity effects and improvement of insulin sensitivity by 1-deoxynojirimycin in animal models. | Journal of agricultural and food chemistry 20080423 |
| New building block for polyhydroxylated piperidine: total synthesis of 1,6-dideoxynojirimycin. | The Journal of organic chemistry 20080404 |
| Gaucher disease: improving management. | Acta paediatrica (Oslo, Norway : 1992) 20080401 |
| Gaucher disease: unmet treatment needs. | Acta paediatrica (Oslo, Norway : 1992) 20080401 |
| Substrate reduction therapy. | Acta paediatrica (Oslo, Norway : 1992) 20080401 |
| Diastereoselective synthesis of piperidine imino sugars using aldol additions of metalated bislactim ethers to threose and erythrose acetonides. | The Journal of organic chemistry 20080321 |
| [New data on Gaucher's disease]. | La Revue de medecine interne 20080301 |
| New perspectives in non-hormonal male contraception. | Trends in endocrinology and metabolism: TEM 20080301 |
| An expeditious one-pot synthesis of 1,6-dideoxy-N-alkylated nojirimycin derivatives and their inhibitory effects on the secretion of IFN-gamma and IL-4. | Bioorganic & medicinal chemistry 20080215 |
| Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR. | Cell calcium 20080201 |
| Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles. | Bioorganic & medicinal chemistry letters 20080201 |
| N-butyldeoxynojirimycin causes weight loss as a result of appetite suppression in lean and obese mice. | Diabetes, obesity & metabolism 20080201 |
| The relationship between 1-deoxynojirimycin content and alpha-glucosidase inhibitory activity in leaves of 276 mulberry cultivars (Morus spp.) in Kyoto, Japan. | Journal of natural medicines 20080101 |
| Enhanced depigmenting effects of N-glycosylation inhibitors delivered by pH-sensitive liposomes into HM3KO melanoma cells. | Journal of cosmetic science 20080101 |
| [Contrast of 1-deoxynojirimycin content in mulberry leaves from different habitats]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080101 |
| [Osteoarticular manifestations of Gaucher disease in adults: pathophysiology and treatment]. | Presse medicale (Paris, France : 1983) 20071201 |
| [Niemann-Pick diseases in adults]. | La Revue de medecine interne 20071201 |
| Divided-dose administration of miglitol just before and 15 minutes after the start of a meal smoothes postprandial plasma glucose excursions and serum insulin responses in healthy men. | Endocrine journal 20071201 |
| [In-vitro study of the drug interactions between Miglitol, an alpha-glucosidase inhibitor, and adsorbents]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20071201 |
| Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis. | The Journal of biological chemistry 20071109 |
| Miglitol increases the adiponectin level and decreases urinary albumin excretion in patients with type 2 diabetes mellitus. | Metabolism: clinical and experimental 20071101 |
| [Alkaloid constituents from silkworm dropping of Bombyx mori]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071101 |
| Occurrence of orally administered mulberry 1-deoxynojirimycin in rat plasma. | Journal of agricultural and food chemistry 20071031 |
| [Adverse effects of alpha-glucosidase inhibitors]. | Nihon rinsho. Japanese journal of clinical medicine 20071028 |
| Administration of miglitol until 30 min after the start of a meal is effective in type 2 diabetic patients. | Diabetes research and clinical practice 20071001 |
| Effects of miglitol, an alpha-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats. | The British journal of nutrition 20071001 |
| Treatment of Niemann-Pick disease type C in two children with miglustat: initial responses and maintenance of effects over 1 year. | Journal of inherited metabolic disease 20071001 |
| Oral maintenance clinical trial with miglustat for type I Gaucher disease: switch from or combination with intravenous enzyme replacement. | Blood 20071001 |
| Influence of food intake on the pharmacokinetics of miglustat, an inhibitor of glucosylceramide synthase. | Journal of clinical pharmacology 20071001 |
| Natural iminosugar derivatives of 1-deoxynojirimycin inhibit glycosylation of hepatitis viral envelope proteins. | Journal of microbiology (Seoul, Korea) 20071001 |
| [Therapeutic objectives in Gaucher disease]. | La Revue de medecine interne 20071001 |
| [Osteoarticular manifestations of Gaucher disease in adults: pathophysiology and treatment]. | La Revue de medecine interne 20071001 |
| [Current development and usefulness of biomarkers for Gaucher disease follow up]. | La Revue de medecine interne 20071001 |
| [Organization of Gaucher disease management in France]. | La Revue de medecine interne 20071001 |
| Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease. | The Journal of biological chemistry 20070928 |
| Synthesis of 4-O-glycosylated 1-deoxynojirimycin derivatives as disaccharide mimics-based inhibitors of human beta-glucocerebrosidase. | Carbohydrate research 20070903 |
| Synthesis and biological evaluation of a small library of nojirimycin-derived bicyclic iminosugars. | Carbohydrate research 20070903 |
| Synthesis and NMR experiments of (4,5,6-13C)-deoxymannojirimycin. A new entry to 13C-labeled glycosidase inhibitors. | Carbohydrate research 20070903 |
| Mutant alpha-galactosidase A enzymes identified in Fabry disease patients with residual enzyme activity: biochemical characterization and restoration of normal intracellular processing by 1-deoxygalactonojirimycin. | The Biochemical journal 20070901 |
| Miglustat for treatment of Niemann-Pick C disease: a randomised controlled study. | The Lancet. Neurology 20070901 |
| Alpha-glucosidase inhibitors from Millettia conraui. | Chemical & pharmaceutical bulletin 20070901 |
| Quantitative determination of 1-deoxynojirimycin in mulberry leaves using liquid chromatography-tandem mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20070815 |
| Effective treatment of an elderly patient with Gaucher's disease and Parkinsonism: a case report of 24 months' oral substrate reduction therapy with miglustat. | Parkinsonism & related disorders 20070801 |
| Effect of miglustat on bone disease in adults with type 1 Gaucher disease: a pooled analysis of three multinational, open-label studies. | Clinical therapeutics 20070801 |
| Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. | Journal of agricultural and food chemistry 20070711 |
| Neurologic improvement in a type 3 Gaucher disease patient treated with imiglucerase/miglustat combination. | Epilepsia 20070701 |
| Mouse sperm rosette: assembling during epididymal transit, in vitro disassemble, and oligosaccharide participation in the linkage material. | Anatomical record (Hoboken, N.J. : 2007) 20070701 |
| [Molecular pathogenesis and therapeutic targets of lysosomal diseases]. | Seikagaku. The Journal of Japanese Biochemical Society 20070701 |
| N-azidoacetylmannosamine-mediated chemical tagging of gangliosides. | Journal of lipid research 20070601 |
| Differential alteration of lipid antigen presentation to NKT cells due to imbalances in lipid metabolism. | European journal of immunology 20070601 |
| Evaluation of the efficacy, safety and tolerability of miglitol in adult Indian patients with uncomplicated type 2 diabetes mellitus. | Journal of the Indian Medical Association 20070601 |
| The alpha(1,2)-mannosidase I inhibitor 1-deoxymannojirimycin potentiates the antiviral activity of carbohydrate-binding agents against wild-type and mutant HIV-1 strains containing glycan deletions in gp120. | FEBS letters 20070515 |
| Selective action of the iminosugar isofagomine, a pharmacological chaperone for mutant forms of acid-beta-glucosidase. | Biochemical pharmacology 20070501 |
| Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity. | Diabetes 20070501 |
| Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. | Nature medicine 20070401 |
| Reduction of the infectivity of hepatitis C virus pseudoparticles by incorporation of misfolded glycoproteins induced by glucosidase inhibitors. | The Journal of general virology 20070401 |
| [Chemical constituents from leaves of Morus multicaulis]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401 |
| Miglustat has no apparent effect on spermatogenesis in normal men. | Human reproduction (Oxford, England) 20070301 |
| A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs. | The Journal of infectious diseases 20070301 |
| [Is it possible to treat the brain? Recent advances in inherited neurodegenerative disorders]. | No to hattatsu = Brain and development 20070301 |
| The pharmacokinetics and tissue distribution of the glucosylceramide synthase inhibitor miglustat in the rat. | Xenobiotica; the fate of foreign compounds in biological systems 20070301 |
| Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man. | The Journal of organic chemistry 20070216 |
| Detection of weak sugar binding activity of VIP36 using VIP36-streptavidin complex and membrane-based sugar chains. | Journal of biochemistry 20070201 |
| Severe endothelial dysfunction in the aorta of a mouse model of Fabry disease; partial prevention by N-butyldeoxynojirimycin treatment. | Journal of inherited metabolic disease 20070201 |
| Chemical chaperones improve transport and enhance stability of mutant alpha-glucosidases in glycogen storage disease type II. | Molecular genetics and metabolism 20070101 |
| Determination of miglitol in human plasma by liquid chromatography/tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20070101 |
| The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study. | Reproductive biology and endocrinology : RB&E 20070101 |
| [Cost reduction in the treatment of Gaucher s disease]. | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101 |
| Substrate deprivation therapy: a new hope for patients suffering from neuronopathic forms of inherited lysosomal storage diseases. | Journal of applied genetics 20070101 |
| Effects of N-glycan processing inhibitors on signaling events and induction of apoptosis in galectin-1-stimulated Jurkat T lymphocytes. | Glycobiology 20061201 |
| Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease. | Bioorganic & medicinal chemistry 20061201 |
| Beneficial effect of intracellular free high-mannose oligosaccharides on cryopreservation of mammalian cells and proteins. | Cryobiology 20061201 |
| Cellobiase from Termitomyces clypeatus: activity and secretion in presence of glycosylation inhibitors. | Biotechnology letters 20061101 |
| Convergent approach toward the synthesis of the stereoisomers of C-6 homologues of 1-deoxynojirimycin and their analogues: evaluation as specific glycosidase inhibitors. | The Journal of organic chemistry 20061027 |
| Polyhydroxylated homoazepanes and 1-deoxy-homonojirimycin analogues: Synthesis and glycosidase inhibition study. | Organic & biomolecular chemistry 20061007 |
| A facile synthesis of 1,6-dideoxynojirimycin from L-sorbose. | Carbohydrate research 20060925 |
| 1,3-Dideoxynojirimycin-3-yl glycosides of beta-(1-->3)- and beta-(1-->6)-linked gluco-oligosaccharides. | Carbohydrate research 20060904 |
| Design and synthesis of highly potent and selective pharmacological chaperones for the treatment of Gaucher's disease. | Chembiochem : a European journal of chemical biology 20060901 |
| Synthesis and evaluation of glycosidase inhibitory activity of N-butyl 1-deoxy-D-gluco-homonojirimycin and N-butyl 1-deoxy-L-ido-homonojirimycin. | Bioorganic & medicinal chemistry 20060815 |
| exo-Imino to endo-iminocyclitol rearrangement. A general route to five-membered antiviral azasugars. | Organic letters 20060803 |
| Inhibition of hybrid- and complex-type glycosylation reveals the presence of the GlcNAc transferase I-independent fucosylation pathway. | Glycobiology 20060801 |
| Reduced inflammatory potential of peritoneal macrophages recruited in mice pretreated with a glycolipid synthesis inhibitor. | Inflammopharmacology 20060801 |
| 1-Deoxynojirimycin derivatives from the marine sponge Lendenfeldia chondrodes. | The Journal of antibiotics 20060801 |
| Gangliosides do not affect ABC transporter function in human neuroblastoma cells. | Journal of lipid research 20060601 |
| 1-Deoxymannojirimycin, the alpha1,2-mannosidase inhibitor, induced cellular endoplasmic reticulum stress in human hepatocarcinoma cell 7721. | Biochemical and biophysical research communications 20060526 |
| Synthesis and biological evaluation of glycosidase inhibitors: gem-difluoromethylenated nojirimycin analogues. | Journal of medicinal chemistry 20060518 |
| Discovery of different types of inhibition between the human and thermotoga maritima alpha-fucosidases by fuconojirimycin-based derivatives. | Biochemistry 20060509 |
| Nucleophilic opening of epoxyazepanes: expanding the family of polyhydroxyazepane-based glycosidase inhibitors. | Organic & biomolecular chemistry 20060507 |
| Long-term non-hormonal male contraception in mice using N-butyldeoxynojirimycin. | Human reproduction (Oxford, England) 20060501 |
| Short-term effect of miglustat in every day clinical use in treatment-naïve or previously treated patients with type 1 Gaucher's disease. | Haematologica 20060501 |
| D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol alters cellular cholesterol homeostasis by modulating the endosome lipid domains. | Biochemistry 20060411 |
| Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat. | FEBS letters 20060403 |
| Pharmacological chaperone corrects lysosomal storage in Fabry disease caused by trafficking-incompetent variants. | American journal of physiology. Cell physiology 20060401 |
| Gaucher disease: multiple lessons from a single gene disorder. | Acta paediatrica (Oslo, Norway : 1992). Supplement 20060401 |
| Asymmetric synthesis of the L-fuco-nojirimycin, a nanomolar alpha-L-fucosidase inhibitor. | Bioorganic & medicinal chemistry letters 20060301 |
| Purification of soluble alpha1,2-mannosidase from Candida albicans CAI-4. | FEMS microbiology letters 20060301 |
| Isolation and structure assignment of an iminotetrasaccharide from a cultured filamentous cyanobacterium Anabaena sp. | Journal of natural products 20060301 |
| [Clinical study of the French cohort of Gaucher disease patients]. | La Revue de medecine interne 20060301 |
| Therapeutic goals in Gaucher disease. | La Revue de medecine interne 20060301 |
| [Pharmacokinetic, pharmacological, and clinical profile of miglitol (SEIBULE), a novel alpha-glucosidase inhibitor]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060301 |
| Synthesis of new nitrogen analogues of salacinol and deoxynojirimycin and their evaluation as glycosidase inhibitors. | The Journal of organic chemistry 20060203 |
| Substrate reduction therapy in the infantile form of Tay-Sachs disease. | Neurology 20060124 |
| Miglustat: substrate reduction therapy for glycosphingolipid lysosomal storage disorders. | Drugs of today (Barcelona, Spain : 1998) 20060101 |
| Emerging strategies for the treatment of hereditary metabolic storage disorders. | Rejuvenation research 20060101 |
| Substrate reduction therapy of glycosphingolipid storage disorders. | Journal of inherited metabolic disease 20060101 |
| Liquid chromatographic tandem mass spectrometry method for the quantification of miglitol in human plasma. | Arzneimittel-Forschung 20060101 |
| alpha-Glucosidase inhibitors have a prolonged antiviral effect against hepatitis B virus through the sustained inhibition of the large and middle envelope glycoproteins. | Antiviral chemistry & chemotherapy 20060101 |
| Miglustat: substrate reduction therapy for lysosomal storage disorders associated with primary central nervous system involvement. | Recent patents on CNS drug discovery 20060101 |
| Looking glass inhibitors: efficient synthesis and biological evaluation of D-deoxyfuconojirimycin. | Carbohydrate research 20051230 |
| Binding residues and catalytic domain of soluble Saccharomyces cerevisiae processing alpha-glucosidase I. | Glycobiology 20051201 |
| Guidance on the use of miglustat for treating patients with type 1 Gaucher disease. | American journal of hematology 20051101 |
| A stereoselective route toward polyhydoxylated piperidines. A total synthesis of (+/-)-deoxymannojirimycin. | Organic letters 20051027 |
| Synthesis of somatostatin mimetics based on the 1-deoxymannojirimycin scaffold. | The Journal of organic chemistry 20051014 |
| The anti-diabetic drug miglitol is protective against anginal ischaemia through a mechanism independent of regional myocardial blood flow in the dog. | Clinical and experimental pharmacology & physiology 20051001 |
| Miglustat: new drug. In type 1 Gaucher's disease : a slight benefit after imiglucerase therapy. | Prescrire international 20051001 |
| An open-label, noncomparative study of miglustat in type I Gaucher disease: efficacy and tolerability over 24 months of treatment. | Clinical therapeutics 20050801 |
| Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator. | The Journal of biological chemistry 20050701 |
| Glucose trimming of N-glycan in endoplasmic reticulum is indispensable for the growth of Raphanus sativus seedling (kaiware radish). | Bioscience, biotechnology, and biochemistry 20050701 |
| Highly stereocontrolled synthesis of gem-difluoromethylenated azasugars: D- and L-1,4,6-trideoxy-4,4-difluoronojirimycin. | Organic letters 20050526 |
| [Determination of 1-deoxynojirimycin in leaves of Morus alba by high performance liquid chromatography with fluorescence detection]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050501 |
| Alpha-glucosidase inhibitors for type 2 diabetes mellitus. | The Cochrane database of systematic reviews 20050418 |
| Alkylated imino sugars, reversible male infertility-inducing agents, do not affect the genetic integrity of male mouse germ cells during short-term treatment despite induction of sperm deformities. | Biology of reproduction 20050401 |
| Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice. | Journal of lipid research 20050401 |
| The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1. Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter. | The FEBS journal 20050401 |
| Biological properties of D- and L-1-deoxyazasugars. | Journal of medicinal chemistry 20050324 |
| The synthesis of hybrids of D-galactose with 1-deoxynojirimycin analogues as glycosidase inhibitors. | Angewandte Chemie (International ed. in English) 20050318 |
| General approach to glycosidase inhibitors. Enantioselective synthesis of deoxymannojirimycin and swainsonine. | The Journal of organic chemistry 20050318 |
| General synthesis and biological evaluation of alpha-1-C-substituted derivatives of fagomine (2-deoxynojirimycin-alpha-C-glycosides). | Bioorganic & medicinal chemistry 20050315 |
| Aglycon specificity profiling of alpha-glucosidases using synthetic probes. | Bioorganic & medicinal chemistry letters 20050301 |
| Substrate reduction therapy for lysosomal storage diseases. | Acta paediatrica (Oslo, Norway : 1992). Supplement 20050301 |
| Computerized cognitive testing in patients with type I Gaucher disease: effects of enzyme replacement and substrate reduction. | Genetics in medicine : official journal of the American College of Medical Genetics 20050201 |
| A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050101 |
| A Madagascar Sponge Batzella sp. as a source of alkylated iminosugars. | Journal of natural products 20050101 |
| Miglustat (NB-DNJ) works as a chaperone for mutated acid beta-glucosidase in cells transfected with several Gaucher disease mutations. | Blood cells, molecules & diseases 20050101 |
| Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile. | Bioorganic & medicinal chemistry letters 20041220 |
| Transgenic mouse expressing human mutant alpha-galactosidase A in an endogenous enzyme deficient background: a biochemical animal model for studying active-site specific chaperone therapy for Fabry disease. | Biochimica et biophysica acta 20041105 |
| NSAIDs increase survival in the Sandhoff disease mouse: synergy with N-butyldeoxynojirimycin. | Annals of neurology 20041101 |
| Simple syntheses of 4-O-glucosylated 1-deoxynojirimycins from maltose and cellobiose. | Carbohydrate research 20041020 |
| Therapy of Niemann-Pick disease, type C. | Biochimica et biophysica acta 20041011 |
| Synthesis of alkylated deoxynojirimycin and 1,5-dideoxy-1,5-iminoxylitol analogues: polar side-chain modification, sulfonium and selenonium heteroatom variants, conformational analysis, and evaluation as glycosidase inhibitors. | Journal of the American Chemical Society 20041006 |
| Biosynthesis of 1-deoxynojirimycin in Commelina communis: a difference between the microorganisms and plants. | Phytochemistry 20041001 |
| Conversion of the carbohydrate structures of glycoproteins in roots of Raphanus sativus using several glycosidase inhibitors. | Journal of biochemistry 20041001 |
| Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells. | The Journal of biological chemistry 20040924 |
| Inhibition of alpha-glucosidases I and II increases the cell surface expression of functional class A macrophage scavenger receptor (SR-A) by extending its half-life. | The Journal of biological chemistry 20040917 |
| Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase. | Chemistry & biology 20040901 |
| Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A. | Chemical communications (Cambridge, England) 20040821 |
| Cellular effects of deoxynojirimycin analogues: uptake, retention and inhibition of glycosphingolipid biosynthesis. | The Biochemical journal 20040801 |
| Cellular effects of deoxynojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides. | The Biochemical journal 20040801 |
| Improved outcome of N-butyldeoxygalactonojirimycin-mediated substrate reduction therapy in a mouse model of Sandhoff disease. | Neurobiology of disease 20040801 |
| Specific inhibition effects of N-pentafluorobenzyl-1-deoxynojirimycin on human CD4+ T cells. | Bioorganic & medicinal chemistry letters 20040716 |
| Golgi endomannosidase inhibitor, alpha-D-glucopyranosyl-(1 --> 3)-1-deoxymannojirimycin: a five-step synthesis from maltulose and examples of N-modified derivatives. | Carbohydrate research 20040712 |
| Asymmetric dihydroxylation of d-glucose derived alpha,beta-unsaturated ester: synthesis of azepane and nojirimycin analogues. | The Journal of organic chemistry 20040709 |
| Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis. | International immunopharmacology 20040701 |
| Antidiabetic drug miglitol inhibits myocardial apoptosis involving decreased hydroxyl radical production and Bax expression in an ischaemia/reperfusion rabbit heart. | British journal of pharmacology 20040701 |
| Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport. | The Journal of biological chemistry 20040618 |
| Inhibitory effects of mulberry leaf extract on postprandial hyperglycemia in normal rats. | Journal of nutritional science and vitaminology 20040601 |
| A general synthesis of iminosugars. | The Journal of organic chemistry 20040514 |
| Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein. | Arteriosclerosis, thrombosis, and vascular biology 20040501 |
| Relations of the type and branch of surface N-glycans to cell adhesion, migration and integrin expressions. | Molecular and cellular biochemistry 20040501 |
| CD28 T cell costimulatory receptor function is negatively regulated by N-linked carbohydrates. | Biochemical and biophysical research communications 20040423 |
| Synthesis of 1-deoxy-D-galactohomonojirimycin via enantiomerically pure allenylstannanes. | The Journal of organic chemistry 20040402 |
| Synthesis of a novel photoaffinity derivative of 1-deoxynojirimycin for active site-directed labeling of glucosidase I. | Glycobiology 20040401 |
| Determination of 1-deoxynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection. | Journal of agricultural and food chemistry 20040324 |
| Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. | Biochemical pharmacology 20040215 |
| An improved purification procedure for soluble processing alpha-glucosidase I from Saccharomyces cerevisiae overexpressing CWH41. | Protein expression and purification 20040101 |
| [Usefulness of miglitol in patients with diabetes mellitus type 2 and insufficient control of the blood glucose]. | Revista clinica espanola 20040101 |
| Sustained therapeutic effects of oral miglustat (Zavesca, N-butyldeoxynojirimycin, OGT 918) in type I Gaucher disease. | Journal of inherited metabolic disease 20040101 |
| Simple and rapid determination of 1-deoxynojirimycin in mulberry leaves. | BioFactors (Oxford, England) 20040101 |
| [Continuation 50. Type 2 diabetes: possibilities and limitations of pharmacological therapy]. | MMW Fortschritte der Medizin 20031218 |
| Glycosidase-substrate interactions analysis by STD-NMR spectroscopy: study of alpha-L-fucosidase. | Journal of the American Chemical Society 20031217 |
| Comparison of kifunensine and 1-deoxymannojirimycin binding to class I and II alpha-mannosidases demonstrates different saccharide distortions in inverting and retaining catalytic mechanisms. | Biochemistry 20031202 |
| Iminosugar glycosidase inhibitors: structural and thermodynamic dissection of the binding of isofagomine and 1-deoxynojirimycin to beta-glucosidases. | Journal of the American Chemical Society 20031126 |
| Detailed dissection of a new mechanism for glycoside cleavage: alpha-1,4-glucan lyase. | Biochemistry 20031111 |
| N-butyldeoxynojirimycin inhibits murine melanoma cell ganglioside metabolism and delays tumor onset. | Cancer letters 20031110 |
| Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective alpha-fucosidase inhibitors. | Angewandte Chemie (International ed. in English) 20031006 |
| General access to iminosugar C-glycoside building blocks by means of cross-metathesis: a gateway to glycoconjugate mimetics. | Organic letters 20030904 |
| Membrane disruption and cytotoxicity of hydrophobic N-alkylated imino sugars is independent of the inhibition of protein and lipid glycosylation. | The Biochemical journal 20030901 |
| Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin. | The Journal of biological chemistry 20030808 |
| Concise and highly stereocontrolled synthesis of 1-deoxygalactonojirimycin and its congeners using dioxanylpiperidene, a promising chiral building block. | Organic letters 20030710 |
| Advancing towards a male contraceptive: a novel approach from an unexpected direction. | Trends in pharmacological sciences 20030701 |
| Chemoenzymatic syntheses of (-)-1-deoxymannojirimycin (DMJ) and its naturally occurring 6-O-alpha-L-rhamnopyranosyl glycoside. | Organic & biomolecular chemistry 20030621 |
| Determination of 1-deoxynojirimycin in Morus alba L. leaves by derivatization with 9-fluorenylmethyl chloroformate followed by reversed-phase high-performance liquid chromatography. | Journal of chromatography. A 20030620 |
| Epitope-dependent blocking of the angiotensin-converting enzyme dimerization by monoclonal antibodies to the N-terminal domain of ACE: possible link of ACE dimerization and shedding from the cell surface. | Biochemistry 20030617 |
| Substrate reduction therapy: clinical evaluation in type 1 Gaucher disease. | Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20030529 |
| Gaucher disease and the clinical experience with substrate reduction therapy. | Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20030529 |
| New synthetic approach to enantiopure bicyclic sulfonium salts: swainsonine analogues. | The Journal of organic chemistry 20030418 |
| Chemical chaperones--a new concept in drug research. | Chembiochem : a European journal of chemical biology 20030404 |
| Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis. | Brain : a journal of neurology 20030401 |
| N-linked oligosaccharide processing, but not association with calnexin/calreticulin is highly correlated with endoplasmic reticulum-associated degradation of antithrombin Glu313-deleted mutant. | Archives of biochemistry and biophysics 20030315 |
| [Therapy decision based on the glucose triad. Drug treatment of type 2 diabetes]. | MMW Fortschritte der Medizin 20030227 |
| [Drug for Gaucher disease also works as sperm inhibitor. Is the 'pill' for the man on its way?]. | MMW Fortschritte der Medizin 20030213 |
| Expression and role of mannose receptor/terminal high-mannose type oligosaccharide on osteoclast precursors during osteoclast formation. | The Journal of endocrinology 20030201 |
| Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin. | The Journal of general virology 20030201 |
| Glycolipid depletion in antimicrobial therapy. | Molecular microbiology 20030101 |
| gem-Diamine 1-N-iminosugars and related iminosugars, candidate of therapeutic agents for tumor metastasis. | Current topics in medicinal chemistry 20030101 |
| Is there a role for alpha-glucosidase inhibitors in the prevention of type 2 diabetes mellitus? | Drugs 20030101 |
| New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases. | Advances in experimental medicine and biology 20030101 |
| A novel method for the assay of alpha-glucosidase inhibitory activity using a multi-channel oxygen sensor. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20021201 |
| Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain. | The Journal of biological chemistry 20021122 |
| Biochemistry and biotechnological applications of Gluconobacter strains. | Applied microbiology and biotechnology 20021101 |
| Therapeutic options for the management of type 2 diabetes mellitus. | The American journal of managed care 20021101 |
| A general strategy for the practical synthesis of nojirimycin C-glycosides and analogues. Extension to the first reported example of an iminosugar 1-phosphonate. | The Journal of organic chemistry 20021004 |
| Understanding protein structure-function relationships in Family 47 alpha-1,2-mannosidases through computational docking of ligands. | Proteins 20021001 |
| HbA(1c) and glycemic profile, basal- and post-treatment with Miglitol, in an area with a Mediterranean diet. | Diabetes care 20021001 |
| Glycosphingolipid lysosomal storage diseases: therapy and pathogenesis. | Neuropathology and applied neurobiology 20021001 |
| The effects of miglitol on glucagon-like peptide-1 secretion and appetite sensations in obese type 2 diabetics. | Diabetes, obesity & metabolism 20020901 |
| The combination of interferon alpha-2b and n-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: implications for hepatitis C virus (HCV) therapy. | Antiviral research 20020901 |
| Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ. | Antiviral chemistry & chemotherapy 20020901 |
| Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins. | The Biochemical journal 20020815 |
| 1-Aza-sugars from D-glucose. Preparation of 1-deoxy-5-dehydroxymethyl-nojirimycin, its analogues and evaluation of glycosidase inhibitory activity. | Bioorganic & medicinal chemistry 20020701 |
| Alpha-glucosidase inhibitor from the seeds of balsam pear (Momordica charantia) and the fruit bodies of Grifola frondosa. | Bioscience, biotechnology, and biochemistry 20020701 |
| Synthesis of 1-deoxy-L-gulonojirimycin (L-guloDNJ) and 1-deoxy-D-talonojirimycin (D-taloDNJ). | Carbohydrate research 20020612 |
| Dose-dependent efficacy of miglitol, an alpha-glucosidase inhibitor, in type 2 diabetic patients on diet alone: results of a 24-week double-blind placebo-controlled study. | Diabetes, nutrition & metabolism 20020601 |
| pH-sensitive liposomes are efficient carriers for endoplasmic reticulum-targeted drugs in mouse melanoma cells. | Biochemical and biophysical research communications 20020510 |
| Interferon-gamma increases the expression of glycosylated CD95 in B-leukemic cells: an inducible model to study the role of glycosylation in CD95-signalling and trafficking. | Cytokine 20020421 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Some amino sugars structurally related to 6-deoxymannojirimycin precursors prepared from methyl 6-deoxy-2,3-O-isopropylidene-alpha-D-lyxo-hexofuranosid-5-ulose and methyl 2,3-O-isopropylidene-alpha-D-lyxo-pentodialdo-1,4-furanoside. | Carbohydrate research 20020417 |
| Inhibition of host ER glucosidase activity prevents Golgi processing of virion-associated bovine viral diarrhea virus E2 glycoproteins and reduces infectivity of secreted virions. | Virology 20020330 |
| Structure of Penicillium citrinum alpha 1,2-mannosidase reveals the basis for differences in specificity of the endoplasmic reticulum and Golgi class I enzymes. | The Journal of biological chemistry 20020215 |
| A simple access to the D-mannosidase inhibitor, 1-deoxymannojirimycin. | Carbohydrate research 20020205 |
| The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step. | Molecular pharmacology 20020101 |
| Potential pharmacokinetics interference between alpha-glucosidase inhibitors and other oral antidiabetic agents. | Diabetes care 20020101 |
| Low-dose N-butyldeoxynojirimycin (OGT 918) for type I Gaucher disease. | Blood cells, molecules & diseases 20020101 |
| [Reducing postprandial glucose levels. Glucosidase antagonists]. | Pharmazie in unserer Zeit 20020101 |
| [Fabry's disease (alpha-galactosidase-A deficiency): recent therapeutic innovations]. | Journal de la Societe de biologie 20020101 |
| Inhibition of catalytic and glucan-binding activities of a streptococcal GTF forming insoluble glucans. | Caries research 20020101 |
| Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides. | The Journal of biological chemistry 20011130 |
| Novel synthesis of the glycosidase inhibitor deoxymannojirimycin and of a synthetic precursor D-lyxo-hexos-5-ulose. | Organic letters 20011018 |
| Miglitol combined with metformin improves glycaemic control in type 2 diabetes. | Diabetes, obesity & metabolism 20011001 |
| Critical role for glycosphingolipids in Niemann-Pick disease type C. | Current biology : CB 20010821 |
| Combination of miglitol, an anti-diabetic drug, and nicorandil markedly reduces myocardial infarct size through opening the mitochondrial K(ATP) channels in rabbits. | British journal of pharmacology 20010801 |
| Galactonojirimycin derivatives restore mutant human beta-galactosidase activities expressed in fibroblasts from enzyme-deficient knockout mouse. | Brain & development 20010801 |
| [The alpha-glucosidase inhibitor miglitol for the treatment of type 2 diabetes mellitus in the doctor's office]. | Fortschritte der Medizin. Originalien 20010719 |
| Role of protein kinase C in the reduction of infarct size by N-methyl-1-deoxynojirimycin, an alpha-1,6-glucosidase inhibitor. | British journal of pharmacology 20010701 |
| Combination of N-methyl-1-deoxynojirimycin and ischemic preconditioning markedly reduces the size of myocardial infarcts in rabbits. | Japanese circulation journal 20010701 |
| A new era in type 2 diabetes mellitus treatment? | The American journal of medicine 20010701 |
| Therapeutic applications of sugar-mimicking glycosidase inhibitors. | Mini reviews in medicinal chemistry 20010701 |
| Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells. | The EMBO journal 20010615 |
| Synthesis and structure determination of some sugar amino acids related to alanine and 6-deoxymannojirimycin. | Carbohydrate research 20010615 |
| The synergistic effect of miglitol plus metformin combination therapy in the treatment of type 2 diabetes. | Diabetes care 20010601 |
| Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications. | Hepatology (Baltimore, Md.) 20010601 |
| Noeuromycin, a glycosyl cation mimic that strongly inhibits glycosidases. | Journal of the American Chemical Society 20010530 |
| Inhibition of N-linked glycosylation. | Current protocols in immunology 20010501 |
| [Alpha-glucosidase inhibitor in type 2 diabetic patients. Metabolism and body weight are favorably modified]. | MMW Fortschritte der Medizin 20010426 |
| Crystal structure of cyclodextrin glucanotransferase from alkalophilic Bacillus sp. 1011 complexed with 1-deoxynojirimycin at 2.0 A resolution. | Journal of biochemistry 20010401 |
| N -butyldeoxynojirimycin reduces growth and ganglioside content of experimental mouse brain tumours. | British journal of cancer 20010401 |
| Retention of glucose on oligosaccharide chains linked to the LH/hCG receptor prevents cell surface expression. | Biochemical and biophysical research communications 20010330 |
| Carbohydrate receptor depletion as an antimicrobial strategy for prevention of urinary tract infection. | The Journal of infectious diseases 20010301 |
| Role of complex asparagine-linked oligosaccharides in the expression of a functional thyrotropin receptor. | The Biochemical journal 20010301 |
| Substrate reduction therapy for glycosphingolipid storage disorders. | Expert opinion on investigational drugs 20010301 |
| Improved glycaemic control with miglitol in inadequately-controlled type 2 diabetics. | Diabetes research and clinical practice 20010301 |
| Slow inhibition of almond beta-glucosidase by azasugars: determination of activation energies for slow binding. | Biochimica et biophysica acta 20010209 |
| Synthesis of D- and L-deoxymannojirimycin via an asymmetric aminohydroxylation of vinylfuran. | Organic letters 20010208 |
| Novel alpha-L-fucosidase inhibitors from the bark of Angylocalyx pynaertii (Leguminosae). | European journal of biochemistry 20010101 |
| Enhanced survival in Sandhoff disease mice receiving a combination of substrate deprivation therapy and bone marrow transplantation. | Blood 20010101 |
| Role of CD44H carbohydrate structure in neuroblastoma adhesive properties. | Medical and pediatric oncology 20010101 |
| Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents. | Proceedings of the National Academy of Sciences of the United States of America 19991012 |
| Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells. | Journal of neurochemistry 19990301 |
| Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases. | Journal of medicinal chemistry 19980702 |
| Boromycin, an anti-HIV antibiotic. | Bioscience, biotechnology, and biochemistry 19960601 |
| Synthesis of alpha-glucosidase I inhibitors showing antiviral (HIV-1) and immunosuppressive activity. | The Journal of pharmacy and pharmacology 19960201 |
| The safety and efficacy of combination N-butyl-deoxynojirimycin (SC-48334) and zidovudine in patients with HIV-1 infection and 200-500 CD4 cells/mm3. | Journal of acquired immune deficiency syndromes 19940201 |
| 6-0-butanoylcastanospermine (MDL 28,574) inhibits glycoprotein processing and the growth of HIVs. | AIDS (London, England) 19910601 |
| Inhibition of HIV and SIV infectivity by blockade of alpha-glucosidase activity. | Virology 19910301 |
| Inhibitory effect of novel 1-deoxynojirimycin derivatives on HIV-1 replication. | AIDS (London, England) 19901001 |
| Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins. | Japanese journal of medical science & biology 19900601 |
| Attenuation of HIV-1 infectivity by an inhibitor of oligosaccharide processing. | AIDS research and human retroviruses 19900601 |
| Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. | Nature 19871101 |
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